BMC Nurs. 2026 Mar 04.
BACKGROUND: Generative artificial intelligence (AI) has the potential to ease the administrative burden placed on nurses and to advance the quality and efficiency of care. Emerging nursing evidence suggests that increasing clinical complexity is associated with missed care, indicating that generative AI may play a role in supporting clinical judgment and streamlining nursing workflows. Despite these possibilities, its use within nursing area remains at an early developmental stage. This study aims to explore current applications of generative AI in clinical nursing, and to identify its advantages and challenges.
METHODS: This integrative review followed the updated methodology of Whittemore and Knafl in 2005. Individual studies in this review were selected based on their relevance to the utilization of generative AI in clinical nursing practice. A literature search was conducted using PubMed, Cochrane, CINAHL, Web of Science, EMBASE, SCOPUS, and Google Scholar, covering the period from January 2000 to September 2025. A quality assessment was performed using a mixed-methods appraisal tool.
RESULTS: The 15 included studies, which were published between 2023 and 2025, comprised randomized controlled trials, cross-sectional studies, qualitative studies, and mixed-methods studies. In clinical nursing practice, generative AI is mainly utilized in three areas: clinical decision-making support, patient education and self-management support for chronic diseases, and efficiency of nursing work. The most common purpose of generative AI is to enhance nursing efficiency. ChatGPT is most frequently used in clinical decision-making support and enhancing nursing workflows, while task-oriented chatbots are primarily applied to patient education and self-management. Generative AI requires enhanced accuracy and reliability through continuous learning from new data, empathic conversations, and human interaction.
CONCLUSIONS: Our findings suggest that the use of generative AI in nursing practice has the potential to support clinical decision-making, educate patients and enable self-management, and improve nursing efficiency. By reducing documentation burdens, optimizing workflows and enabling personalized care, generative AI could enhance nursing practice. However, these findings should be interpreted cautiously given the heterogeneity of study designs and the predominantly exploratory nature of the available evidence. The integration of generative AI into nursing practice requires continued improvements in accuracy, reliability, empathic interaction and meaningful human involvement. These potential benefits can be realized by nurses, with appropriate competencies and a critical understanding of both the advantages and limitations of generative AI being fostered.
CLINICAL TRIAL NUMBER: Not applicable.
Keywords: Generative artificial intelligence; Hospitals; Nurses; Practical nursing; Review literature as topic