bims-evares Biomed News
on Evaluation of research
Issue of 2022–03–27
43 papers selected by
Thomas Krichel, Open Library Society
  1. Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020.
  2. Healthcare Management: A Bibliometric Analysis Based on the Citations of Research Articles Published between 1967 and 2020.
  3. The Top 100 Cited Articles on Plantar Fasciitis: A Bibliometric Analysis.
  4. Relationship between modifiable lifestyle factors and chronic kidney disease: a bibliometric analysis of top-cited publications from 2011 to 2020.
  5. Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis.
  6. International Publication Trends in Low Back Pain Research: A Bibliometric and Visualization Analysis.
  7. Diabetes-related foot disease research in Aotearoa New Zealand: a bibliometric analysis (1970-2020).
  8. Bibliometric Mapping of Literature on High-Entropy/Multicomponent Alloys and Systematic Review of Emerging Applications.
  9. Burnout amongst radiologists: A bibliometric study from 1993 to 2020.
  10. Pediatric brain tumors: a bibliometric analysis.
  11. Management of Chronic Myeloid Leukemia and Pregnancy: A Bibliometric Analysis (2000-2020).
  12. [Revista Chilena de Pediatría/Andes Pediatrica in the new millennium. Bibliometric analysis].
  13. Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis.
  14. A 10-Year Scientometrics Analysis of Brain Tumors Treated with Gamma Knife Radiosurgery: Visualization, Characteristics, and Scientific Trends.
  15. Beyond the Impact Factor: An Alternative Approach to Measure the Influence of the Journal Sexually Transmitted Diseases on STI Prevention and Practice.
  16. E-Learning Research Trends in Higher Education in Light of COVID-19: A Bibliometric Analysis.
  17. The landscape of hematology research in Brazil: an analysis of data from citation databases.
  18. AMP-activated protein kinase(AMPK) channel: A Global Bibliometric analysis From 2012 to 2021.
  19. Ocular Adverse Effects in Atopic Dermatitis Patients Treated With Dupilumab: A Bibliometric Analysis.
  20. Bibliometric analysis of global research progress on electrochemical degradation of organic pollutants.
  21. Does origin of article impact citation metrics in Gynecologic Oncology?
  22. [The citation analysis of the articles published in Chinese Journal of Otorhinolaryngology Head and Neck Surgery from 2009 to 2019].
  23. Analyzing the Scholarly Impact of Cardiothoracic Surgery Research Using the Relative Citation Ratio.
  24. The Under-representation and Stagnation of Female, Black, and Hispanic Authorship in the Journal of the American Medical Association and the New England Journal of Medicine.
  25. A bibliometric analysis on the tribological and physicochemical properties of vegetable oil-based bio-lubricants (2010-2021).
  26. Machine-Learning-Based Disease Diagnosis: A Comprehensive Review.
  27. A Report of Journal of Obesity and Metabolic Syndrome in the Last 3 Years of Upheaval.
  28. Response to Comments on "The 100 Most Cited Articles on Lumbar Spinal Stenosis: A Bibliometric Analysis." Global Spine J by Chen Y et al.
  29. Meta-synthesis and science mapping analysis of HIV/HPV co-infection: a global perspective with emphasis on Africa.
  30. Characteristics of International Medical Graduates in Academic Plastic Surgery.
  31. Assessing the academic achievement of United States orthopaedic departments.
  32. Suggestions to the article: demonstrating the ascendancy of COVID-19 research using acronyms.
  33. Interactions between Street Food and Food Safety Topics in the Scientific Literature-A Bibliometric Analysis with Science Mapping.
  34. The Price of Publishing: An Investigation of the Open Access Landscape in Plastic Surgery.
  35. Research Trends and Market Opportunities of Microalgal Biorefinery Technologies from Circular Bioeconomy Perspectives.
  36. Changes in Helicobacter pylori Treatment from Discovery to Nowadays: A High-Level Analysis of PubMed Publications.
  37. Detecting the Knowledge Domains of Compound Semiconductors.
  38. "Broad" Impact: Perceptions of Sex/Gender-Related Psychology Journals.
  39. The gulf of cross-disciplinary research collaborations on global river basins is not narrowed.
  40. Does Journal Content in the Field of Women's Health Represent Women's Burden of Disease? A Review of Publications in 2010 and 2020.
  41. Significant Contribution of Spanish Dermatology Toward Understanding COVID-19: A Bibliometric Study of PubMed-Indexed Articles.
  42. Alternative Metrics as an Impact Measure for Dermatology Journals.
  43. The Impact of Industry Funding on Randomized Controlled Trials of Biologic Therapies.
  1. J Control Release. 2022 Mar 20. pii: S0168-3659(22)00157-2. [Epub ahead of print]
    Bibliometric and visualized analysis of ocular drug delivery from 2001 to 2020.
    Cheng Peng, Liangju Kuang, Jiangyue Zhao, Amy E Ross, Zhongqing Wang, Joseph B Ciolino.
       OBJECTIVE: To perform a bibliometric analysis in the field of ocular drug delivery research to characterize the current international trends and to present visual representations of the past and emerging trends on ocular drug delivery research over the past decade.
    METHOD: In this cross-sectional study, a bibliometric analysis of data retrieved and extracted from the Web of Science Core Collection (WoSCC) database was performed to analyze evolution and theme trends on ocular drug delivery research from January 1, 2001, to December 31, 2020. A total of 4334 articles on ocular drug delivery were evaluated for specific characteristics, such as publication year, journals, authors, institutions, countries/regions, references, and keywords. Co-authorship analysis, co-occurrence analysis, co-citation analysis, and network visualization were constructed by VOSviewer. Some important subtopics identified by bibliometric characterization were further discussed and reviewed.
    RESULTS: From 2001 to 2020, the annual global publications increased by 746.15%, from 52 to 440. International Journal of Pharmaceutics published the most manuscripts (250 publications) and produced the highest citations (9509 citations), followed by Investigative Ophthalmology & Visual Science (202 publications) and Journal of Ocular Pharmacology and Therapeutics (136 publications). The United States (1289 publications, 31,512 citations), the University of Florida (82 publications, 2986 citations), and Chauhan, Anuj (52 publications, 2354 citations) were the most productive and impactful institution, country, and author respectively. The co-occurrence cluster analysis of the top 100 keywords forms five clusters: (1) micro/nano ocular drug delivery systems; (2) the treatment of inflammation and posterior diseases; (3) macroscopic ocular drug delivery systems/devices; (4) the characteristics of drug delivery systems; (5) and the ocular drug delivery for glaucoma treatment. Diabetic macular edema, anti-VEGF, ranibizumab, bevacizumab, micelles and latanoprost, were the latest high-frequency keywords, indicating the emerging frontiers of ocular drug delivery. Further discussions into the subtopics were provided to assist researchers to determine the range of research topics and plan research direction.
    CONCLUSIONS: Over the last two decades there has been a progressive increase in the number of publications and citations on research related to ocular drug delivery across many countries, institutions, and authors. The present study sheds light on current trends, global collaboration patterns, basic knowledge, research hotspots, and emerging frontiers of ocular drug delivery. Novel solutions for ocular drug delivery and the treatment of inflammation and posterior diseases were the major themes over the last 20 years.
    Keywords:  Bibliometrics; Bioavailability; Hydrogels; Mucoadhesive polymer; Nanoparticles; Ocular drug delivery
    DOI:  https://doi.org/10.1016/j.jconrel.2022.03.031
  2. Healthcare (Basel). 2022 Mar 16. pii: 555. [Epub ahead of print]10(3):
    Healthcare Management: A Bibliometric Analysis Based on the Citations of Research Articles Published between 1967 and 2020.
    Oana Păduraru, Alina Moroșanu, Călin Ștefan Păduraru, Elena Mihaela Cărăușu.
      The purpose of this study is to analyse the trends manifested in research literature from the field of healthcare management, with emphasis on bibliometric features and different influencing factors. For this, a search was conducted of nine academic databases between January and May 2021. Article features were registered in our database after first applying the validation criteria used for their inclusion. Then, data regarding the publication of the included articles were collected. The analysis focused on trends over time, topic, and journals in which they were published. Moreover, the effect of some factors on the citation of articles was analysed. Our results showed that the 250 analysed articles were published in 139 journals, and many of were by researchers affiliated with universities in the United States. Over time, the publication of analysed articles and their number of citations registered a continuous increase. The most common topics of focus were healthcare management systems and their challenges. In our study, we identified factors that significantly affect citation number, such as number of years since publication, the number of words in the title, and the number of authors of an article. In addition, major gaps were identified, as were new unresolved challenges that can trigger new research ideas.
    Keywords:  bibliometric analysis; health management; healthcare
    DOI:  https://doi.org/10.3390/healthcare10030555
  3. J Foot Ankle Surg. 2022 Feb 28. pii: S1067-2516(22)00059-X. [Epub ahead of print]
    The Top 100 Cited Articles on Plantar Fasciitis: A Bibliometric Analysis.
    Kaylem M Feeney.
      Plantar fasciitis is a common musculoskeletal complaint seen in clinical practice. The objective of this study was to perform a bibliometric analysis of the top 100 articles published on the topic of plantar fasciitis. The Web of Science platform was used to search for articles on plantar fasciitis published between 1975 and 2021. Articles were subsequently ranked from the most to least cited. The top 100 studies were analyzed and their characteristics described. A total of 1859 articles were identified. The most cited article was "A retrospective case-control injuries analysis of 2002 running" published by Taunton JE et al in the British Journal of Sports Medicine in 2002. This article had a total of 910 citations. The mean number of citations per article in the top 100 was 139.95 (range 83-910). The majority of articles were published between the years 2000 to 2009 (n = 56). The USA had the highest number of publications (n = 55), while 'Foot and Ankle International' was the journal with the most publications in the top 100 (n =10). Plantar fasciitis is a well-studied topic. Despite this, however, a significant interest in plantar fasciitis research remains among clinicians and researchers evident by the high number of recent studies published on this topic. It is anticipated that these more recent studies will become highly cited over time and as such, this bibliometric analysis should be continuously updated.
    Keywords:  analysis; article; bibliometric; citation; plantar fasciopathy
    DOI:  https://doi.org/10.1053/j.jfas.2022.02.012
  4. BMC Nephrol. 2022 Mar 25. 23(1): 120
    Relationship between modifiable lifestyle factors and chronic kidney disease: a bibliometric analysis of top-cited publications from 2011 to 2020.
    Ting Yin, Yilong Chen, Lei Tang, Huaihong Yuan, Xiaoxi Zeng, Ping Fu.
       BACKGROUND: Chronic kidney disease (CKD) affects 8 to 16% of the world's population and is one of the top ten important drivers of increasing disease burden. Apart from genetic predisposition, lifestyle factors greatly contribute to the incidence and progression of CKD. The current bibliometric analysis aims to characterize the current focus and emerging trends of the research about the impact of modifiable lifestyle factors on CKD.
    METHODS: We searched articles addressing the impact of modifiable lifestyle factors on the incidence and/or progression of CKD, published between 2011 and 2020, from the Science Citation Index Expanded (SCIE) database. An adjusted citation index, which considered both the original citation count and publication year, was derived for the selection of most-cited publications. Publishing trends, co-authorship network, keywords, and research hotspots were analyzed and visualized.
    RESULTS: Among the top 100 most influential articles, 32 were narrative reviews, 16 systematic reviews and/or meta-analysis, 44 clinical research, and 8 basic research. The United States occupied a dominant position in the perspective of article numbers and international partnerships, followed by European countries. The modifiable factors that drew the most and constant attention over the decade were diet or nutrition management reported in 63 papers, followed by obesity or body mass index (n = 27), and physical activity or exercises (n = 8). Alcohol consumption, fish oil, chain fatty-acids, and water-soluble vitamins were emerging hotspots identified in the recent most cited publications.
    CONCLUSIONS: Based on the bibliometric analysis of the most influential articles, our study provides a comprehensive description of publishing trends and research focus over a decade in the field of lifestyle factors' impact on CKD. Diet, obesity, and physical activity were factors receiving the most attention in this topic.
    Keywords:  Bibliometric analysis; Chronic kidney disease; Diet; Lifestyle; Modifiable factors; Obesity; Physical activity
    DOI:  https://doi.org/10.1186/s12882-022-02745-3
  5. Front Med (Lausanne). 2022 ;9 814381
    Global Research Status of Multiple Organ Dysfunction Syndrome During 2001-2021: A 20-Year Bibliometric Analysis.
    Peng-Yue Zhao, Yun Xia, Zheng-Bo Tao, Song-Yan Li, Zhi Mao, Xing-Peng Yang, Ren-Qi Yao, Xiao-Hui Du.
       Background: Multiple Organ Dysfunction Syndrome (MODS) is a major cause of high morbidity and mortality among patients in intensive care units (ICU). Although numerous basic and clinical researches on MODS have been conducted, there is still a long way to go to prevent patients from entering this stage. To our knowledge, no bibliometric analyses of MODS have been reported, this study, therefore, was conducted to reveal MODS research status and trends during 2001-2021.
    Methods: All relevant literature covering MODS during 2001-2021 were extracted from Web of Science. An online analysis platform of literature metrology was used to analyze the publication trends. VOSviewer software was used to collect and analyze the keywords and research hotspots related to MODS.
    Results: As of July 31, 2021, a total of 994 MODS-related articles from 2001 to 2021 were identified. The United States accounted for the largest number of publications (31.1%), followed by China and Germany, with 186 and 75 publications, respectively. Among all the institutions, the University of Pittsburgh published the most papers related to MODS (21). Critical Care Medicine published the most papers in this field (106). Professor Moore EE, who had the most citation frequency (1847), made great achievements in MODS research. Moreover, analysis of the keywords identified three MODS research hotspot clusters: "mechanism-related research," "clinical research," and "diagnostic research."
    Conclusions: The United States maintained a top position worldwide and made the most outstanding contribution in the MODS field. In terms of publication, China was next only to the United States, but there was a disproportion between the quantity of publications and citation frequency. The institution University of Pittsburgh and journal Critical Care Medicine represent the highest level of research in this field. During the 20 years from 2001 to 2021, basic MODS research has been in-depth yet progressed relatively slowly recently, but the outbreak of COVID-19 has to some extent set off an upsurge of clinical research in MODS field.
    Keywords:  MODS; bibliometric analysis; keywords; publication; research hotspots
    DOI:  https://doi.org/10.3389/fmed.2022.814381
  6. Front Public Health. 2022 ;10 746591
    International Publication Trends in Low Back Pain Research: A Bibliometric and Visualization Analysis.
    Fan Huang, Beisi Zheng, Cunshu Wu, Siyi Zhao, Yuanyue Xu, Ziyuan Li, Chuyu Huang, Zhiyong Fan, Shan Wu.
       Background: Although there is a growing research base on low back pain, the bibliometric literature related to it is deficient. The aim of this study was to conduct a bibliometric and visualization analysis of low back pain and to provide a broad view of the current trends in LBP research and a potential guide in this discipline.
    Methods: The authors searched the Web of Science to extract publications regarding low back pain, and found a total of 12,249 publications during a period of 22 years, among which 12,242 were eligible. We classified and analyzed publications such as total citations, average citations per item, H-index, research types, countries/regions, institutions, and journals using standard bibliometric indicators. Bibliometric approaches (VOSviewer1.6.13 and CiteSpace 5.8.3) were also available for gathering information and explore the trends of research.
    Results: Conspicuously, over the past 22 years, an increasing number of scholars have specialized in the research of LBP, exerting the boom in articles. The largest number of document type was that of articles. Under modern conditions, regional distinction existed in the research of low back pain and developed countries preceded others. Research individuals and institutions were preoccupied by respective aspects. Visualization analysis provided objective information for potential collaborators and cooperative institutions. Furthermore, most burst keywords varied during different periods.
    Conclusions: The map of research on LBP obtained by our analysis is expected to help researchers to efficiently and effectively explore LBP.
    Keywords:  bibliometric analysis; low back pain; publications; trend; visualization
    DOI:  https://doi.org/10.3389/fpubh.2022.746591
  7. J Foot Ankle Res. 2022 Mar 21. 15(1): 23
    Diabetes-related foot disease research in Aotearoa New Zealand: a bibliometric analysis (1970-2020).
    Matthew Carroll, Ibrahim Saleh Al-Busaidi, Kirsten J Coppell, Michele Garrett, Belinda Ihaka, Claire O'Shea, Justina Wu, Steve York.
       BACKGROUND: The aim of this bibliometric study was to examine trends in the quality and quantity of published diabetes-related foot disease (DRFD) research in Aotearoa/New Zealand (NZ) over the past five decades.
    METHOD: In July 2021, the Scopus® database was searched for DRFD-related publications (1970-2020) using predetermined search and inclusion criteria. Bibliometric data were extracted from Scopus® and Journal Citation Reports. Retrieved bibliometric indicators were analysed in Biblioshiny, an R Statistical Software interface and reported using descriptive statistics.
    RESULTS: Forty-seven DRFD-related articles were identified. The annual number of publications showed a significant upward trend increasing from one in 1988 to a peak of six in 2018 (P < 0.001). The majority of identified articles (n = 31, 66%) were published in the last decade (2011-2020). Basic/clinical research accounted for 87% (n = 41) of publications and 14 (30%) investigated the screening and/or prevention of DRFD. The average citation per article was 20.23 (range: 0-209) and the median impact factor was 4.31 (range, 1.82-79.32). Over a third of articles (36%) had an international authorship network. Funding was reported in 15 (32%) articles; 12 (26%) were supported by public national grants vs. three (6%) reporting industry-sponsorship.
    CONCLUSION: DRFD articles authored by NZ researchers have increased over the past five decades. Despite NZ researchers having increased their global impact through collaborative networks, most of the research was classified as low-level evidence, with limited focus on Indigenous Māori and limited financial support and funding. Increased funding for interventional research is required to enable a higher level of evidence-based and practice-changing research to occur. With rates of diabetes-related amputations higher in Māori future research must focus on reducing inequalities in diabetes-related outcomes for Māori by specifically targeting the prevention and screening of DRFD in primary care settings in NZ.
    Keywords:  Aotearoa New Zealand; Bibliometric analysis; Diabetes mellitus; Diabetes-related foot disease; Diabetic foot; Research
    DOI:  https://doi.org/10.1186/s13047-022-00528-5
  8. Entropy (Basel). 2022 Feb 24. pii: 329. [Epub ahead of print]24(3):
    Bibliometric Mapping of Literature on High-Entropy/Multicomponent Alloys and Systematic Review of Emerging Applications.
    Akeem Damilola Akinwekomi, Farid Akhtar.
      High-entropy/multicomponent alloy (HEA/MCA) has received significant research attention in the last decade. There is a dearth of data-driven works dedicated to assessing and visualizing the HEA/MCA literature from a global perspective. To this end, we present the first bibliometric literature analysis of more than 3500 HEA/MCA articles, published between 2004 and 2021, in the Scopus database. We identify the most prolific authors, their collaborators, institutions, and most prominent research outlet. Co-occurrence networks of keywords are mapped and analyzed. A steep rise in research outputs is observed from 2013, when the number of annual publications doubled the previous years. The top five preferred research outlets include Journal of Alloys and Compounds, Materials Science and Engineering A, Scripta Materialia, Intermetallics, and Acta Materialia. Most of these publications emanate from researchers and institutions within China, USA, and Germany, although international scientific collaboration among them is lacking. Research gaps and future research directions are proposed, based on co-occurrence frequencies of author keywords. Finally, a brief systematic review of emerging applications, covering hydrogen storage, additive manufacturing, catalysis, and superconductivity, is undertaken. This work provides an important comprehensive reference guide for researchers to deepen their knowledge of the field and pursue new research directions.
    Keywords:  VOSviewer; bibliometric mapping; high-entropy alloy; multicomponent alloy; text-mining
    DOI:  https://doi.org/10.3390/e24030329
  9. World J Psychiatry. 2022 Feb 19. 12(2): 368-378
    Burnout amongst radiologists: A bibliometric study from 1993 to 2020.
    Muhammad Fazal Hussain Qureshi, Danish Mohammad, Syed Mustafa Ali Shah, Mahira Lakhani, Muzna Shah, Muhammad Hassan Ayub, Sara Sadiq.
       BACKGROUND: Burnout amongst radiologists is common in many different institutions and is increasing day by day. To battle burnout, we have to address the root causes already recognized in published literature. Therefore, it is crucial to examine and discern important publications.
    AIM: To provide evidence-based data and trends related to burnout in radiologists so that researchers can work on it further and develop preventive strategies to overcome this problem.
    METHODS: Bibliometric analysis conducted by two independent reviewers separately used Scopus Library for data extraction by using medical subject heading and International Classification of Diseases keywords. Forty-nine articles were selected for analysis after an extensive scrutiny. Statistical Package for the Social Sciences version 20 was used for analysis. Pearson correlation coefficient, Kruskal Wallis test, and Mann-Whitney U test were applied.
    RESULTS: The most productive period with regards to the number of publications was between 2017 and 2019. A total of 160 authors contributed to the topic burnout among radiologists, with an average of 3.26 authors per paper. About 41.68% of the authors were female, whilst 35% of them were first authors. The co-citation analysis by author involved 188 cited authors, 13 of whom were cited at least 70 times. Only six out of forty-nine studies were funded by various government institutions and non-governmental organizations.
    CONCLUSION: Current analysis casts a spotlight on important trends being witnessed in regard to the mental health of radiologists, including lack of funding for mental health research, narrowing of female vs male citation gap, as well as authorship and citation trends.
    Keywords:  Analysis; Bibliometric; Burnout; Radiologist; Scientometrics; Stress
    DOI:  https://doi.org/10.5498/wjp.v12.i2.368
  10. Childs Nerv Syst. 2022 Mar 19.
    Pediatric brain tumors: a bibliometric analysis.
    Muhammet Arif Ozbek, Fatma Yardibi, Berkhan Genç, Ahmet Tulgar Basak, Alican Tahta, Nejat Akalan.
       PURPOSE: The purpose of this study was to identify tendency and current issues in research on pediatric brain tumors over the past 20 years and to help researchers and investors explore new directions for future research in this subject.
    METHODS: Web of Science Core Collection was used for article selection and CiteSpace 5.8.R 1 was used for bibliometric analyses with these articles.
    RESULTS: The overall h-index was found to be 131 in the analysis made in a total of 4019 publications on the subject between the years 2000 and 2021. A total of 16,101 authors have published articles on pediatric brain tumors. The most active author in this field was Michael D. Taylor (h-index: 105). The publication which received the strongest citation burst among publications was published in 2016 by Louis et al. published in Acta Neuropathologica, and its content is the World Health Organization's classification of central nervous system tumors. Considering the country contribution, the USA is seen in the leading position. The most publications on the subject were followed by the Journal of Clinical Oncology.
    CONCLUSION: By examining the studies on childhood brain tumors carried out around the world, the subjects that can be determined as the focus were tried to be highlighted. And it has been seen that the scientific and industrial community should work together and the financial support for multidisciplinary studies should increase.
    Keywords:  Bibliometric analysis; CiteSpace; Pediatric brain tumors; Pediatric neurosurgery
    DOI:  https://doi.org/10.1007/s00381-022-05506-7
  11. Front Oncol. 2022 ;12 826703
    Management of Chronic Myeloid Leukemia and Pregnancy: A Bibliometric Analysis (2000-2020).
    Yue Wang, Liqing Jiang, Baoxuan Li, Yan Zhao.
       Background: Given the increasing number and survival rates of reproductive-age patients with chronic myeloid leukemia (CML), several studies aimed to elucidate optimum disease management in pregnancy. This study aimed to use bibliometric analysis to assess focus and reported insights, as well as future trends, in CML and pregnancy research.
    Methods: We extracted all studies related to CML and pregnancy from the Web of Science database from 2001 to 2020. VOS Viewer, CiteSpace, Python, and R-bibliometrix were used for bibliometric analysis, revealing the leading research countries, institutions, and authors, as well as distribution of keywords (frequency greater than five).
    Results: A total of 196 records, published in 137 journals by 1,105 authors from 421 research institutes in 50 countries, were identified for analysis. The United States was the leader in the number of publications. Imperial College London and National Research Center for Hematology were the most influential institutions. In addition, Apperley J, Cortes J, Abruzzese E and Kantarjian H were the leading authors in the field. Keyword analysis identified four research hotspot clusters.
    Conclusions: This study systematically analyzed the progress in CML and pregnancy research in the last 20 years. The present findings suggest that the management of planned and unplanned pregnancies in patients with CML will remain a research focus, as further evidence is required for the development of treatment guidelines.
    Keywords:  bibliometric analysis; chronic myeloid leukemia; fertility preservation; keyword analysis; pregnancy
    DOI:  https://doi.org/10.3389/fonc.2022.826703
  12. Andes Pediatr. 2021 Oct;pii: S2452-60532021005000902. [Epub ahead of print]92(5): 739-746
    [Revista Chilena de Pediatría/Andes Pediatrica in the new millennium. Bibliometric analysis].
    Luisa Schonhaut B, Ilan Oppenheimer S, Catalina Del Rio G, Vicente Pizarro F, Italo Costa-Roldan, Paul R Harris, Francisco Cano Sch.
       INTRODUCTION: Andes Pediatrica/Revista Chilena de Pediatría (AP/RChP), maintains a document profile that covers all scientific publication formats, from Original Articles (OAs) to Letters to the Editor. Adequate editorial planning requires a long-term bibliometric analysis.
    OBJECTIVE: To describe the profile of OAs published in AP/RChP in the last two decades.
    METHODOLOGY: From a controlled vocabulary list, the thematic and methodological descriptors of the documents from 2000 to 2020 were standardi zed. Nationality, sex, and profession of the authors, document typology, and design of the OAs were analyzed, as well as the descriptors cited in Google Scholar and the most visited descriptors on the journal's website in recent years.
    RESULTS: 1738 manuscripts were published, 580 (33.4%) were OAs, with an increase from 59 to 129 OAs between the first and last three years. The average number of authors was higher for OAs (4.7) than for non-originals (3.0). In 2020, there were nine multicenter collaborations from different countries. The number of OAs by foreign authors increased from 3.3% to 28.7%, the first authorship by non-medical professionals increased from 15% to 31%, and there was a predominance of female first authors (ratio 1.4/1). Of the OAs, 9.1% were experimental, 3.3% were qualitative and the rest were quantitative observational. The most published descriptors were Nutrition, Infectious Diseases, Neonatology, and Pneumonology, while the most cited descriptors were Nutrition, Neonatology, and Oral Health, with no trend among the most visited. 44% of the most cited articles and 35% of the most visited articles were OAs.
    CONCLUSIONS: A significant increase in published OAs stands out, with a low frequency of experimental designs. Authors of different na tionalities and professions participated. OAs represent one-third of the visits and almost half of the citations, with no correlation between the most published and most cited descriptors.
    DOI:  https://doi.org/10.32641/andespediatr.v92i5.3916
  13. Int J Environ Res Public Health. 2022 Mar 21. pii: 3742. [Epub ahead of print]19(6):
    Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis.
    Hongxia Jin, Lu Lu, Haojun Fan.
      Long COVID is a condition distinguished by long-term sequelae that occur or persist after the convalescence period of COVID-19. During the COVID-19 pandemic, more and more people who tested positive for SARS-CoV-2 experienced long COVID, which attracted the attention of researchers. This study aims to assess the pattern of long COVID research literature, analyze the research topics, and provide insights on long COVID. In this study, we extracted 784 publications from Scopus in the field of long COVID. According to bibliometric analysis, it is found that: developed countries in Europe and America were in leading positions in terms of paper productivity and citations. The International Journal of Environmental Research and Public Health and the Journal of Clinical Medicine were leading journals in the perspective of publications count, and Nature Medicine had the highest number of citations. Author Greenhalgh T has the highest number of papers and citations. The main research topics were: pathophysiology, symptoms, treatment, and epidemiology. The causes of long COVID may be related to organ injury, inflammation, maladaptation of the angiotensin-converting enzyme 2 (ACE2) pathway, and mental factors. The symptoms are varied, including physical and psychological symptoms. Treatment options vary from person to person. Most patients developed at least one long-term symptom. Finally, we presented some possible research opportunities.
    Keywords:  bibliometric analysis; long COVID; network analysis; publication; research hotspots; research trends; social network analysis
    DOI:  https://doi.org/10.3390/ijerph19063742
  14. J Cancer Epidemiol. 2022 ;2022 7136868
    A 10-Year Scientometrics Analysis of Brain Tumors Treated with Gamma Knife Radiosurgery: Visualization, Characteristics, and Scientific Trends.
    Walkiria Garcia-Fuentes, Leonardo Espinoza-Rodriguez, Arnaldo Munive-Degregori, Cesar Mauricio-Vilchez, Maria Eugenia Guerrero, Josmel Pacheco-Mendoza, Frank Mayta-Tovalino.
       Objective: To evaluate the scientometrics characteristics of the scientific production on the treatment of brain tumors with gamma knife radiosurgery in Scopus.
    Methods: The Scopus database (Elsevier) was used to collect all relevant studies for this bibliometric analysis. Data was obtained as a .csv file; it was downloaded from Scopus and was exported by SciVal to Microsoft Excel for a presentation using tables for more detailed analysis. The citations and the number of papers for the most productive institutions, authors, countries, and journals publishing scientific papers were analyzed on the use of gamma knife radiosurgery for brain tumors.
    Results: 458 metadata were obtained from scientific publications, on which inclusion and exclusion criteria were applied, leaving 248 studies. The maximum peak of publications was 2018 with 31 publications, and the minimum peak was 2015 with 18. The most related subtopics were neurology, surgery, and oncology, and most of the retrieved papers had only institutional collaboration. As for more productive journals, Journal of Neurosurgery is first with 23 publications; within the countries with the most scientific publications, we have the United States, Japan, and China. With the United States being the country with the highest number of productions, University of Texas MD Anderson Cancer Center was the main university with the highest scientific production and Sheehan and Trifiletti and American authors dominate the list with the highest number of documents.
    Conclusion: Scientific production regarding gamma knife surgery and brain tumors has been increasing during the last 10 years, with a high incidence during 2018, and the highest number of published articles was in the first quartile. Likewise, the United States is the country with the most publications, authors, and universities on the subject. Greater efforts are still lacking from all countries in the world to reach the quantity and quality of production of the United States.
    DOI:  https://doi.org/10.1155/2022/7136868
  15. Sex Transm Dis. 2022 Mar 11.
    Beyond the Impact Factor: An Alternative Approach to Measure the Influence of the Journal Sexually Transmitted Diseases on STI Prevention and Practice.
    Cornelis A Rietmeijer, William C Miller.
       BACKGROUND: A journal's quality is often assessed by its impact factor, a measure of the number of times a journal's published articles are cited in the scientific literature. However, the impact factor may not adequately measure a journal's influence on practice. As an alternative approach, we analyzed referenced articles of the 2015 and 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections (STI) Treatment Guidelines, arguably the most influential document on STI prevention and care in the Unites States.
    METHODS: Referenced articles in the 2015 and 2021 guidelines were abstracted and analyzed by source and year of publication and sources were ranked by frequency of citation.
    RESULTS: Of 892 citations in 2015 and 1454 citations in 2021, the most frequently cited reference sources included the journals Sexually Transmitted Diseases (14.0% and 12.8% in 2015 and 2021 respectively), Clinical Infectious Diseases (7.5% and 8.2%), and Sexually Transmitted Infections (5.6% and 6.4%).
    CONCLUSION: STI specialty journals influence STI prevention and practice beyond what would be expected from the journals' impact factor alone.
    DOI:  https://doi.org/10.1097/OLQ.0000000000001628
  16. Front Psychol. 2021 ;12 762819
    E-Learning Research Trends in Higher Education in Light of COVID-19: A Bibliometric Analysis.
    Said Khalfa Mokhtar Brika, Khalil Chergui, Abdelmageed Algamdi, Adam Ahmed Musa, Rabia Zouaghi.
      This paper provides a broad bibliometric overview of the important conceptual advances that have been published during COVID-19 within "e-learning in higher education." E-learning as a concept has been widely used in the academic and professional communities and has been approved as an educational approach during COVID-19. This article starts with a literature review of e-learning. Diverse subjects have appeared on the topic of e-learning, which is indicative of the dynamic and multidisciplinary nature of the field. These include analyses of the most influential authors, of models and networks for bibliometric analysis, and progress towards the current research within the most critical areas. A bibliometric review analyzes data of 602 studies published (2020-2021) in the Web of Science (WoS) database to fully understand this field. The data were examined using VOSviewer, CiteSpace, and KnowledgeMatrix Plus to extract networks and bibliometric indicators about keywords, authors, organizations, and countries. The study concluded with several results within higher education. Many converging words or sub-fields of e-learning in higher education included distance learning, distance learning, interactive learning, online learning, virtual learning, computer-based learning, digital learning, and blended learning (hybrid learning). This research is mainly focused on pedagogical techniques, particularly e-learning and collaborative learning, but these are not the only trends developing in this area. The sub-fields of artificial intelligence, machine learning, and deep learning constitute new research directions for e-learning in light of COVID-19 and are suggestive of new approaches for further analysis.
    Keywords:  COVID-19; Web of Science (WoS) database; bibliometric analysis; e-learning; higher education
    DOI:  https://doi.org/10.3389/fpsyg.2021.762819
  17. Hematol Transfus Cell Ther. 2022 Mar 04. pii: S2531-1379(22)00034-7. [Epub ahead of print]
    The landscape of hematology research in Brazil: an analysis of data from citation databases.
    Erich Vinicius De Paula, Marcio Souza Martins, Ana Luisa Bortoluzo De Lorenzo, Bruno Kosa Lino Duarte, Suely Meireles Rezende, Fernando Ferreira Costa.
       INTRODUCTION: Scientometrics is the field concerned with measuring and analyzing academic literature, using specific metrics and data from bibliometric databases. Hematology is a broad area of science and medicine, from which several landmark scientific discoveries have emerged.
    OBJECTIVE: The aim of this report is to provide a snapshot of the landscape of hematology research in Brazil, based on a comprehensive analysis of published studies in hematology whose authors were affiliated to Brazilian institutions from 1980 to 2020.
    METHOD: Articles, reviews and letters to the editor with at least one author affiliated to a Brazilian institution were retrieved from Incytes/Web of Science or Scopus databases. Importantly, only papers classified in the subject area "Hematology" by the embedded algorithms of each database were included.
    RESULTS: Considering all published papers, Brazil is in the 22nd position, contributing with around 1.1% of papers in this period. A clear and sustained increase in publication output can be observed from the early 1990's to the present moment. Publicly-funded higher education institutions were the main contributors to the development and consolidation of the hematology scientific community, which has grown in diversity, with an increasing number of contributions from private institutions. In regard to funding, public agencies have been and remain by large as the most important funder of research in hematology in Brazil.
    CONCLUSION: We suggest that continuous monitoring of the temporal trends of some of the data compiled in our report could potentially contribute to a clearer picture of the development of hematology research in Brazil.
    Keywords:  Bibliometrics; Hematology; Research output; Scientific production; Scientometrics
    DOI:  https://doi.org/10.1016/j.htct.2022.02.001
  18. Channels (Austin). 2022 Dec;16(1): 60-71
    AMP-activated protein kinase(AMPK) channel: A Global Bibliometric analysis From 2012 to 2021.
    Tianyi Lyu, Chuanxi Tian, Tianyang Tan, Jiaxuan Lyu, Kang Yan, Xirui Zhao, Ruoshui Wang, Chaoyang Zhang, Meng Liu, Yulong Wei.
      In recent years, AMPK channel has gained considerable attention in a variety of research areas, and several academic journals have published articles on AMPK research. However, few attempts have been made to thoroughly assess the scientific output and current status systematically in this topic from a worldwide viewpoint. As a result, it is critical to adopt an appropriate visualization method to reveal the global status, future research trends, and hotspots in AMPK channel research. To investigate research hotspots/frontiers in certain domains, bibliometric analysis has been frequently utilized to determine the productivity of nations, institutions, authors, and the frequency of keywords. In this work, we used CiteSpace and VOSviewer to conduct a bibliometric analysis of AMPK channel studies from 2012 to 2021 in order to perform researchers with some directions for AMPK channel research.
    Keywords:  AMPK; bibliometric analysis; cancer; metabolic diseases; stroke
    DOI:  https://doi.org/10.1080/19336950.2022.2049543
  19. Front Med (Lausanne). 2022 ;9 802036
    Ocular Adverse Effects in Atopic Dermatitis Patients Treated With Dupilumab: A Bibliometric Analysis.
    Qian-Nan Jia, Ju Qiao, Kai Fang, Yue-Ping Zeng.
       Background: Atopic dermatitis (AD) is one of the most common chronic inflammatory skin disorders. Dupilumab, the first targeted biological drug approved for the treatment of AD, has been widely used, along with increasing ocular adverse effects (AEs).
    Objective: To perform a bibliometric analysis of all the qualified literature involving ocular AEs during the treatment of AD with dupilumab.
    Methods: Relevant studies were extracted from the Web of Science database and screened by researchers. The bibliographic analysis was performed using the VOSviewer.
    Results: A total of 138 articles were enrolled in this study. The first study was published in 2016 by Oregon Health and Science University from the United States. The majority of publications were published in the past 3 years. British Journal of Dermatology published the highest number of articles. The United States was the country with the most publications. Sanofi (France) and Regeneron Pharmaceuticals (USA) were the leading organizations with the most contributions. Conjunctivitis was the most common ocular AE. The management of AD will continue to be the research hotspot and development trend in this area. The milestone research is the first article "Two Phase 3 Trials of Dupilumab vs. Placebo in Atopic Dermatitis" published in the New England Journal of Medicine. Most of the top 10 papers were mainly randomized, placebo-controlled phase 2 and phase 3 clinical trials and real-life large cohort studies.
    Conclusions: This study may help better understand ocular AEs in the dupilumab treatment of AD, and grasp the research trends and most influential topics in this field.
    Keywords:  atopic dermatitis; bibliometric; conjunctivitis; dupilumab; ocular adverse effects
    DOI:  https://doi.org/10.3389/fmed.2022.802036
  20. Environ Sci Pollut Res Int. 2022 Mar 19.
    Bibliometric analysis of global research progress on electrochemical degradation of organic pollutants.
    José Ribamar Nascimento Dos Santos, Ismael Carlos Braga Alves, Aldaléa Lopes Brandes Marques, Edmar Pereira Marques.
      As a result of anthropogenic action, an increasing amount of toxic organic compounds has been released into the environment. These pollutants have adverse effects on human health and wildlife, which has motivated the development of different types of technologies for the treatment of effluents and contaminated environments. The electrochemical degradation of organic pollutants has attracted the interest of research centers around the world for its environmental compatibility, high efficiency, and affordable cost. In the present study, a bibliometric analysis was performed using the Web of Science database in order to assess the progress of publications related to electrochemical degradation of organic pollutants between the years 2001 and 2021. The data retrieved showed a significant increase in publications related to the topic in the last 20 years. Electrochimica Acta was the magazine responsible for the largest number of publications (291, 6.52%). The studies mainly included the areas of engineering, chemistry, and environmental science ecology. China with a total of 1472 (32.96%) publications dominated research in this area, followed by Spain (436, 9.76%) and Brazil (345, 7.72%). The institutions with the highest number of contributions were the University of Barcelona and the Chinese Academy of Sciences, and the most productive authors were Brillas E. and Oturan M. A. The results of this study provide important references and information on possible research directions for future investigations on electrochemical degradation of organic pollutants.
    Keywords:  Bibliometric study; Electrochemical oxidation; Electrode materials; Environment pollution; Organic contaminants; Scientific production
    DOI:  https://doi.org/10.1007/s11356-022-19534-y
  21. Gynecol Oncol Rep. 2022 Apr;40 100958
    Does origin of article impact citation metrics in Gynecologic Oncology?
    Logan Corey, Christopher Walker, Alex Corey, Jonathan Konel, Ali Khalil, Hyejeong Jang, Seongho Kim, Radhika Gogoi.
       Objectives: To determine if the origin of article published in Gynecologic Oncology ("Journal") is correlated with quality of the article when measured per US institution and per country, using an index of citation (IOC) metric as a stand-in for article quality.
    Methods: PubMed was used to query the Journal from 2005 to 2020. Articles not deemed original research were excluded. A US-only cohort ("US-Only") was evaluated separately from the entire cohort ("Whole"). The IOC for each article was calculated by dividing the number of citations listed in PubMed by the days from the publication date to 9/1/2021. The IOC per US institution was summarized by the median value. All articles were hand reviewed for correctness. The Whole cohort included all countries with 3 or more publications (including all of the US-Only cohort) and underwent similar analysis. Correlation coefficients were estimated using Pearson's correlation after log-transformation.
    Results: In the US-only cohort, 2733 articles from 276 institutions within the US contributed original articles to the Journal. The association between the number of publications per institution and the median IOC was not well correlated (Pearson's Correlation coeffeicient r = 0.16, p = 0.009). In the Whole cohort, 5,848 original research articles were published from 40 countries. There was no difference between median IOC for articles from US compared to non-US institutions was (0.0026 vs 0.0027, p = 0.287). The US median IOC was ranked 17/40. The US accounted for just over half (51.2%) of publications, and there was a trend of decreasing Non-US publications over time (p = 0.0004).
    Conclusions: The Journal was fairly consistent in the quality of articles published over the 15-year study period when using the IOC as a surrogate for quality, regardless of the article's country or US institution of origin.
    Keywords:  Double blind review; International contributors; Peer review
    DOI:  https://doi.org/10.1016/j.gore.2022.100958
  22. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Mar 07. 57(3): 333-337
    [The citation analysis of the articles published in Chinese Journal of Otorhinolaryngology Head and Neck Surgery from 2009 to 2019].
    Y Fang, X Jin, Q Wu, L S Yang, Y X Fang.
      Objective: To analyze the citation of articles in Chinese Journal of Otorhinolaryngology Head and Neck Surgery, and to explore the strategy for running scientific journals. Methods: Using the Citation Database of Chinese Biomedical Journals, the citations of articles in this journal from 2009 to 2019 were statistically analyzed, and the characteristics of highly cited articles were analyzed. Results: From 2009 to 2019, Chinese Journal of Otorhinolaryngology Head and Neck Surgery published 2 814 papers. Cited papers accounted for 75.69% of all papers, and each paper was cited 7.24 times. The citation rate of published papers was consistent with the variation trend of citation frequency. Non treatises such as guide consensus and original articles for special issues were cited better. There was no obvious correlation between paper funding and citation. Conclusion: Improving the content quality and optimizing the column setting are important measures to enhance the influence of scientific journals.
    DOI:  https://doi.org/10.3760/cma.j.cn115330-20220121-00040
  23. J Surg Res. 2022 Mar 17. pii: S0022-4804(22)00075-0. [Epub ahead of print]275 265-272
    Analyzing the Scholarly Impact of Cardiothoracic Surgery Research Using the Relative Citation Ratio.
    Hanjay Wang, Simar S Bajaj, Kiah M Williams, Christian T O'Donnell, Joseph C Heiler, Aravind Krishnan, Joshua M Pickering, Mark Sanchez, Keerthi Manjunatha, Sean S Kumar, Maggie M Yu, Jack H Boyd.
       INTRODUCTION: The National Institutes of Health (NIH) recently developed the relative citation ratio (RCR), calculated as article citations benchmarked to NIH-funded publications in the same field. Here, we characterized the scholarly impact of academic cardiothoracic (CT) surgeons and their research using the RCR.
    MATERIALS AND METHODS: Using a database of 992 CT surgeons, we calculated the RCR for all articles published by each surgeon since 1980 using the NIH iCite database. All data were collected from publicly available online sources. Data are presented as median (interquartile range) or as odds ratios (ORs) for multivariable logistic regression analysis.
    RESULTS: Where RCR 1.00 indicates equal impact as an NIH-funded publication, the RCR among all 37,402 CT surgery articles was 0.84 (0.33-1.83) and the RCR among NIH-funded CT surgery articles was 1.07 (0.53-2.17). CT surgeons exhibited a career median RCR of 0.82 (0.54-1.13) and maximum RCR of 6.20 (3.04-13.57). Predictors of career median RCR >1.00 included female gender (OR 2.23, P = 0.001), thoracic subspecialization (OR 2.50, P < 0.001), full professor rank (OR 1.89, P = 0.001), and NIH funding (OR 1.75, P = 0.001). Predictors of career maximum RCR >50th percentile among CT surgeons included male gender (OR 1.87, P = 0.030), thoracic subspecialization (OR 2.05, P < 0.001), full professor rank (OR 4.89, P < 0.001), NIH funding (OR 3.17, P < 0.001), and career duration (OR 1.03, P = 0.002).
    CONCLUSIONS: We present the first assessment of the NIH-validated RCR for academic CT surgery. CT surgery research is highly impactful, although gender disparities persist with respect to the highest-impact research of our specialty.
    Keywords:  Cardiac; Impact; Relative citation ratio; Research; Thoracic
    DOI:  https://doi.org/10.1016/j.jss.2022.02.007
  24. J Racial Ethn Health Disparities. 2022 Mar 21.
    The Under-representation and Stagnation of Female, Black, and Hispanic Authorship in the Journal of the American Medical Association and the New England Journal of Medicine.
    Moustafa Abdalla, Mohamed Abdalla, Salwa Abdalla, Mohamed Saad, David S Jones, Scott H Podolsky.
      Publication in leading medical journals is critical to knowledge dissemination and academic advancement alike. Leveraging a novel dataset comprised of nearly all articles published in JAMA and NEJM from 1990 to 2020, along with established reference works for name identification, we explore changing authorship demographics in two of the world's leading medical journals. Our main outcomes are the annual proportion of male and female authors and the proportion of racial/ethnic identities in junior and senior authorship positions for articles published in JAMA and NEJM since 1990. We found that women remain under-represented in research authorship in both JAMA (at its peak, 38.1% of articles had a female first author in 2011) and NEJM (peaking at 28.2% in 2002). The rate of increase is so slow that it will take more than a century for both journals to reach gender parity. Black and Hispanic researchers have likewise remained under-represented as first and last authors in both journals, even using the best-case scenario. Their appearance as authors has remained stagnant for three decades, despite attention to structural inequalities in medical academia. Thus, analysis of authorship demographics in JAMA and NEJM over the past three decades reveals the existence of inequalities in high-impact medical journal authorship. Gender and racial/ethnic disparities in authorship may both reflect and further contribute to disparities in academic advancement.
    Keywords:  Authorship; Ethnic disparities; Gender disparities; Medical journals; Racial disparities
    DOI:  https://doi.org/10.1007/s40615-022-01280-z
  25. Environ Sci Pollut Res Int. 2022 Mar 25.
    A bibliometric analysis on the tribological and physicochemical properties of vegetable oil-based bio-lubricants (2010-2021).
    Chiew Tin Lee, Mei Bao Lee, Guo Ren Mong, William Woei Fong Chong.
      Vegetable oil-based bio-lubricants possess potential as an alternative to mineral oil-based lubricants due to their biodegradability and renewability. However, a detailed examination of the publication focus, trend, and future direction related to these bio-lubricants' tribological and physicochemical properties is scarce. Therefore, the study presents a bibliometric analysis of vegetable oil-based bio-lubricant. One hundred sixty-five publications were extracted from Web of Science (WoS) from 2010 to 2021. During this period, the total citation was 2,240, recording an average citation per publication of 13.58. Proceedings of The Institution of Mechanical Engineers, Part J: Journal of Engineering Tribology was the top productive journal, publishing 10.3% of the publications selected on the studied topic. From 2010 to 2021, India was the most productive country working on bio-lubricants due to its abundance of coconut products, followed by Malaysia due to its abundance of palm products. The keyword analysis indicated that a significant amount of work emphasised the derivation of bio-lubricants with an increasing shift towards tribological performance characterisation. From the analysis, palm is the most studied bio-lubricant, followed by castor oil. The reported viscosity and viscosity index values cover an extensive range, allowing these bio-lubricants to be adopted for a wide range of applications. For different vegetable oil-based bio-lubricants, the coefficient of friction is reported from 0.001 to 0.78, with the wear scar diameter being reported from 0.075 μm to 4.59 mm. Even though these bio-lubricants' friction and wear performances can be tabulated, the dataset is still unreliable for lubricant-selection purposes because of the varying test conditions. Such a scenario also limits the ability to correlate the role of fatty acid composition in the vegetable oil-based bio-lubricants in fulfilling their various application-specific potentials. Therefore, this study recommends that a unified correlation between the fatty acid composition and its tribological performance be attained consistently to better elucidate the potential of vegetable oil-based bio-lubricants.
    Keywords:  Biodegradability; Fatty acid composition; Friction; Renewability; VOSviewer; Wear
    DOI:  https://doi.org/10.1007/s11356-022-19746-2
  26. Healthcare (Basel). 2022 Mar 15. pii: 541. [Epub ahead of print]10(3):
    Machine-Learning-Based Disease Diagnosis: A Comprehensive Review.
    Md Manjurul Ahsan, Shahana Akter Luna, Zahed Siddique.
      Globally, there is a substantial unmet need to diagnose various diseases effectively. The complexity of the different disease mechanisms and underlying symptoms of the patient population presents massive challenges in developing the early diagnosis tool and effective treatment. Machine learning (ML), an area of artificial intelligence (AI), enables researchers, physicians, and patients to solve some of these issues. Based on relevant research, this review explains how machine learning (ML) is being used to help in the early identification of numerous diseases. Initially, a bibliometric analysis of the publication is carried out using data from the Scopus and Web of Science (WOS) databases. The bibliometric study of 1216 publications was undertaken to determine the most prolific authors, nations, organizations, and most cited articles. The review then summarizes the most recent trends and approaches in machine-learning-based disease diagnosis (MLBDD), considering the following factors: algorithm, disease types, data type, application, and evaluation metrics. Finally, in this paper, we highlight key results and provides insight into future trends and opportunities in the MLBDD area.
    Keywords:  COVID-19; artificial neural networks; convolutional neural networks; deep learning; deep neural networks; diabetes; disease diagnosis; heart disease; kidney disease; machine learning; review
    DOI:  https://doi.org/10.3390/healthcare10030541
  27. J Obes Metab Syndr. 2022 Mar 21.
    A Report of Journal of Obesity and Metabolic Syndrome in the Last 3 Years of Upheaval.
    Eun-Jung Rhee.
      Journal of Obesity and Metabolic Syndrome (JOMES) is the official journal of the Korean Society for the Study of Obesity (KSSO) and is a peer-reviewed research journal that presents relevant academic research and the newest medical information in the field of obesity. JOMES was launched in 1992, with the foundation of the KSSO and diverse studies on obesity published under the title Journal of the Korean Society for the Study of Obesity until 2004. Since its publication in full English in 2017, JOMES was rapidly registered in numerous databases, that is, in PubMed Central in 2018, in Emerging Sources Citation Index and in SCOPUS in 2019. In addition, JOMES is indexed in KoreaMed, Science Central, EBSCO, DOAJ and Google Scholar. The increase in the number of citations of JOMES within Web of Science is astonishing, and the world is reading and citing JOMES. In this review, I'd like to review the current status of JOMES and share the rapid development of JOMES with readers and potential authors of JOMES.
    Keywords:  Journal; Obesity; Research
    DOI:  https://doi.org/10.7570/jomes22020
  28. Global Spine J. 2022 Mar 25. 21925682221085553
    Response to Comments on "The 100 Most Cited Articles on Lumbar Spinal Stenosis: A Bibliometric Analysis." Global Spine J by Chen Y et al.
    Xing Ding, Mengchen Yin, Chongqing Xu, Wen Mo.
      
    DOI:  https://doi.org/10.1177/21925682221085553
  29. Global Health. 2022 Mar 24. 18(1): 36
    Meta-synthesis and science mapping analysis of HIV/HPV co-infection: a global perspective with emphasis on Africa.
    Hope Onohuean, Eric O Aigbogun, Bright E Igere.
       BACKGROUND: Viral infections are emerging with diverse clinical relevance both in endemic environments and non-endemic regions of the world. Some of the viruses cause co-infections that are of public health importance. The progress of studies on human immunodeficiency virus / Human papillomavirus (HIV/HPV) co-infection is not well documented especially in Africa where cases are endemic.
    METHOD: Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a global three-decade meta-synthesis and science mapping analysis on HIV/HPV co-infections. Assessment of progress, Author/Country productivity/trends, topic conceptual framework, and international collaborative networks were analyzed.
    RESULTS: We recovered 196 documents of 115 sources from the web of science database. The meta-synthesis revealed 1203 prolific authors containing nine solo authors, an annual growth rate of 8.09%, a significant average citation per article of 20.7%, and an average citation per year per document of 2.1. A significant high correlation between the mean/TC per article and the mean total citation (TC) per year showed 80.98% of the articles produced between 2005 and 2007 on HPV/HIV co-infection. The co-author per document index were 7.0 and the collaboration index was 6.4. The meta-analysis also revealed inadequate funding from individual or governmental organizations; among the 196 documents dataset, 114 (58.2%) were funded, and only 31 (15.8%) were funded in Africa where HIV/HPV co-infection cases are endemic.
    CONCLUSIONS: Authors' collaboration network, countries' collaboration, authors' citations and implementation of research-based finding in previous studies are yet to receive the relevant outcome, especially as various countries in the African continent have received poor funding with a repeated reporting of co-infection associated with HIV/HPV. African needs to re-awaken and stir up research-based interest in HPV/HIV co-infection studies to resolve indigenous public health concerns associated with the viral endemicity.
    Keywords:  Africa; HPV/HIV co-infection; Mapping analysis; Public health concern; Research advancement; meta-synthesis
    DOI:  https://doi.org/10.1186/s12992-022-00812-w
  30. Plast Reconstr Surg. 2022 Mar 21.
    Characteristics of International Medical Graduates in Academic Plastic Surgery.
    Francesco M Egro, Julia Lai, Nallammai Muthiah, Brandon T Smith, Vu T Nguyen.
       BACKGROUND: International medical graduates play a significant role in meeting U.S. health care needs, and contribute to a more diverse provider workforce. This study aimed to determine the prevalence, characteristics, and academic productivity of plastic surgery international medical graduate faculty.
    METHODS: A cross-sectional study was conducted to compare characteristics of international medical graduates against domestic medical graduates including demographics, trainings, academic ranks, leadership positions, number of publications and citations, and Hirsch index.
    RESULTS: International medical graduates represent 10.3 percent of all 918 academic plastic surgeons in the United States, with the majority having graduated from India (16.8 percent), Brazil (8.4 percent), and the United Kingdom (8.4 percent). International medical graduates were more likely to have graduated from independent programs (OR, 5.7; p < 0.0001) and to have completed research fellowship (OR, 2.1; p = 0.0001) and burn fellowship (OR, 6.5; p < 0.0001). Programs led by international medical graduate chairs employed more international medical graduate faculty (21 percent versus 9 percent; p < 0.0001). International medical graduates had comparable Hirsch indices, number of publications, and citations, but received less National Institutes of Health funding ($32,020 versus $223,365). International medical graduates also had comparable rates of attaining leadership positions such as fellowship director and chair but required fewer years of experience to become residency director (8.3 years versus 17.3 years).
    CONCLUSIONS: The contribution of international medical graduates in academic plastic surgery was evident based on research productivity, academic ranks, and leadership positions. International medical graduates are more likely to be employed in programs led by international medical graduate chairs. This study may help guide aspiring international medical graduate academics and aid in hiring decisions at academic institutions.
    DOI:  https://doi.org/10.1097/PRS.0000000000009008
  31. World J Orthop. 2022 Feb 18. 13(2): 201-211
    Assessing the academic achievement of United States orthopaedic departments.
    Rishi Trikha, Thomas E Olson, Ameen Chaudry, Chad R Ishmael, Cristina Villalpando, Clark J Chen, Kellyn R Hori, Nicholas M Bernthal.
       BACKGROUND: Assessing academic productivity allows academic departments to identify the strengths of their scholarly contribution and provides an opportunity to evaluate areas for improvement.
    AIM: To provide objective benchmarks for departments seeking to enhance academic productivity and identify those with significant improvement in recent past.
    METHODS: Our study retrospectively analyzed a cohort of orthopaedic faculty at United States-based academic orthopaedic programs. 5502 full-time orthopaedic faculty representing 178 programs were included in analysis. Variables included for analysis were National Institutes of Health funding (2014-2018), leadership positions in orthopaedic societies (2018), editorial board positions of top orthopaedic journals (2018), total number of publications and Hirsch-index. A weighted algorithm was used to calculate a cumulative score for each academic program. This study was performed at a large, United States medical school.
    RESULTS: All 178 programs included in analysis were evaluated using the comprehensive weighted algorithm. The five institutions with the highest cumulative score, in decreasing order, were: Washington University in St. Louis, the Hospital for Special Surgery, Sidney Kimmel Medical College (SKMC) at Thomas Jefferson University, the University of California, San Francisco (UCSF) and Massachusetts General Hospital (MGH)/Brigham and Women's/Harvard. The five institutions with the highest score per capita, in decreasing order, were: Mayo Clinic (Rochester), Washington University in St. Louis, Rush University, Virginia Commonwealth University (VCU) and MGH/Brigham and Women's/Harvard. The five academic programs that had the largest improvement in cumulative score from 2013 to 2018, in decreasing order, were: VCU, SKMC at Thomas Jefferson University, UCSF, MGH/Brigham and Women's/Harvard, and Brown University.
    CONCLUSION: This algorithm can provide orthopaedic departments a means to assess academic productivity, monitor progress, and identify areas for improvement as they seek to expand their academic contributions to the orthopaedic community.
    Keywords:  Academic achievement; Bibliometrics; Hirsch-index; National Institutes of Health funding; Number of publications
    DOI:  https://doi.org/10.5312/wjo.v13.i2.201
  32. Scientometrics. 2022 Mar 12. 1-3
    Suggestions to the article: demonstrating the ascendancy of COVID-19 research using acronyms.
    Julie Chi Chow, Tsair-Wei Chien, Willy Chou.
      The article published on 16 May 2021 is interesting and impressive, particularly on the Figure displaying several acronyms in trend. Although the most popular eight acronyms in 2019 and 2020 are individually highlighted and labeled, how to determine the points in 2019 and 2020 is required for classifications. The analysis for the evolution of keywords is common and necessary in the bibliographic study. None of the studies addressed the determination of the bursting point for a given keyword over the years. We aim to illustrate the way to determine the inflection point on a given ogive curve and apply the temporal bar graph (TBG) to interpret the trend of a specific keyword (or acronym). The prediction model is based on item response theory, commonly used in educational and psychometric fields. The eight acronyms presented in the previous study were demonstrated using the TBG. We found that the TBG includes more valuable information than the traditional trend charts. The inflection point denoted the topic burst indicates the turning point suddenly from increasing to decreasing. The TBG combined with the inflection point to represent the trend of a given keyword can make the data in trend easier and clearer to understand than any graph used in ever before bibliometric analyses.
    Keywords:  Acronym; Bibliometric analysis; Item response theory; Prediction model; Temporal bar graph
    DOI:  https://doi.org/10.1007/s11192-022-04302-z
  33. Foods. 2022 Mar 09. pii: 789. [Epub ahead of print]11(6):
    Interactions between Street Food and Food Safety Topics in the Scientific Literature-A Bibliometric Analysis with Science Mapping.
    Claudio Bellia, Simona Bacarella, Marzia Ingrassia.
      Street food (SF) consists of ready-to-eat food prepared and sold on the street. This food constitutes the food traditions of local populations in many countries of the world. SF characterizes a large number of cities around the world, from New York to Paris, from Palermo to cities of North Africa, China, India and Japan. SF is inexpensive and prepared following traditional methods that meet local consumer preferences, culinary culture and lifestyles. Moreover, SF allows a unique experience for tourists who also want to experience a destination through traditional food consumed on the street together with the locals. Nevertheless, SF is linked to several health hazards. Hence, several studies discussed on the compliance with hygiene and food quality requirements that SF vendors should guarantee, to ensure human health. So far, there is no bibliometric review attempting to provide an objective and comprehensive analysis of the existing scientific documents that simultaneously study the scientific topic of SF linked to that of Food Safety (FS). Therefore, the objective of this paper is to provide a theoretical framework of the interactions between studies on SF and FS topics, in order to discover if the combined topic of "Street Food Safety" (SFS) was investigated as a topic in its own right. A bibliometric analysis was carried out analyzing 276 scientific contributions from the last 21 years, indexed in the Elsevier Scopus database and in the Clarivate Web of Science database. The results showed a very strong interaction between the two topics and many others in several scientific sectors; In particular, the topic of SFS involves many disciplines of social sciences. The results highlight that the scientific topic of SFS exists but not consciously, and it is believed that the research interest in this topic can grow considerably in the coming years, also because of the current COVID-19 pandemic situation that we are experiencing.
    Keywords:  consumer health; food consumption; food security; street food safety; sustainable food systems
    DOI:  https://doi.org/10.3390/foods11060789
  34. Plast Reconstr Surg. 2022 Mar 21.
    The Price of Publishing: An Investigation of the Open Access Landscape in Plastic Surgery.
    Pooja S Yesantharao, Chao Long, Justin M Sacks, Gordon K Lee, Rahim S Nazerali.
       BACKGROUND: Open access publishing in plastic surgery has rapidly gained traction in the past decade. This study investigated the digital landscape of plastic surgery open access publishing.
    METHODS: This was a cross-sectional bibliometric investigation of plastic surgery-focused journals. Three publication models were investigated: subscription-only journals, hybrid journals offering both paywalled and open access publishing, and open access-only journals.
    RESULTS: Eighty-two journals were investigated. In 2010, open access journals comprised 18 percent of all plastic surgery journals online, subscription journals comprised 79 percent, and hybrid journals comprised 3 percent. Conversely, in 2020, open access journals comprised 55 percent of all journals, hybrid journals comprised 45 percent, and there were no subscription-only journals. Multivariable linear regression adjusting for article type/content demonstrated that open access articles from hybrid journals [beta coefficient, 1.3; F(4, 18) = 790; p = 0.05] and high-quality open access journals [beta coefficient, 0.9; F(4, 19) = 738; p = 0.04] were significantly positively associated with number of full-text views. Although impact factor and article processing charges were positively correlated [Pearson correlation coefficient: r(25) = 0.39, p = 0.04] for open access publishing, some high-quality open access journals were found to offer fee waivers/free publishing. Lastly, level of evidence offered by articles from open access versus hybrid journals differed.
    CONCLUSIONS: Overall, this study highlighted important distinctions between trustworthy and predatory journals offering open access publishing in plastic surgery. Open access publishing in trustworthy sources offers greater visibility and is not necessarily cost-prohibitive, but some open access journals can be limited in scope (i.e., less coverage of subspecialty topics) and quality of content. Study findings were used to generate recommendations for navigating open access publishing in plastic surgery.
    DOI:  https://doi.org/10.1097/PRS.0000000000009016
  35. Bioresour Technol. 2022 Mar 21. pii: S0960-8524(22)00367-4. [Epub ahead of print] 127038
    Research Trends and Market Opportunities of Microalgal Biorefinery Technologies from Circular Bioeconomy Perspectives.
    Bunushree Behera, Mari Selvam S, Balasubramanian Paramasivan.
      Microalgae as an alternative feedstock for sustainable bio-products have gained significant interest over years. Even though scientific productivity related to microalgae-based research has increased in recent decades, translation to industrial scale is still lacking. Therefore, it is essential to understand the current state-of-art and, identify research gaps and hotspots driving industrial scale up. The present review through scientometric analysis attempted to delineate the research evolution contributing to this emerging field. The research trends were analysed in terms of the publication rates over the last decade globally highlighting the collaborative network between the countries. The comprehensive knowledge map generated confirmed microalgal biorefinery as a scientifically active field, where the present research interest is focussed on synergistically integrating the unit processes involved to make it enviro-economically feasible. Market opportunities and regulatory policy requirements along with the consensus need to adopt circular bio-economy perspectives were highlighted to facilitate real-time implementation of microalgal biorefinery.
    Keywords:  Biorefinery; Circular bio-economy; Enviro-economic feasibility; Market; Microalgae; Research trend
    DOI:  https://doi.org/10.1016/j.biortech.2022.127038
  36. Clin Exp Gastroenterol. 2022 ;15 51-58
    Changes in Helicobacter pylori Treatment from Discovery to Nowadays: A High-Level Analysis of PubMed Publications.
    Eyal Klang, Shelly Soffer, Yiftach Barash, Eyal Shachar, Adi Lahat.
       Background: Since the discovery of Helicobacter pylori (H. pylori) 40 years ago, treatment options have changed dramatically adjacent to new drugs development and the emergence of multi-drug resistance. In this study, we aimed to assess published literature on treatment regimens for H. pylori in the past four decades, with regards to specific drug resistance and geographic distribution.
    Methods: We have queried PubMed for all available H. pylori-related entries published during 1987-2020. For each entry, we retrieved the title, abstract, and keywords. Two gastrointestinal specialists decided in consensus on a list of terms to classify entries. The terms specify types of treatment and different types of regimens. Annual trends of publications were plotted for different treatment types and sub-analyses.
    Results: Overall, 47,170 H. pylori-related entries were published between 1987 and 2020. Medication treatment showed the highest number of total publications 6183/47,170 (13.1%), followed by antibiotics 5493/47,170 (11.6%), and probiotic which was substantially lower (0.7%). For treatment regimens type, triple therapy had the highest number of publications 2400/47,170 (5.1%) followed by sequential therapy 342/47,170 (0.7%), and bismuth quadruple therapy 115/47,170 (0.2%). Analysis by antibiotic resistance showed that clarithromycin treatment had the highest number of publications 3537/47,170 (7.5%). Since 2013, there is a steep upward slope (5.1±0.7 publications/year, p < 0.001) for publications originating from China.
    Conclusion: Our findings reflect the changes of the commonly prescribed regimens along the years, following the occurrence and the rise of H. pylori antibiotic resistance. In recent years, there is a steep rise in publications in countries with policies of screening and eradication for gastric cancer prevention, which is currently not applied in Western countries. A text-mining analysis of H. pylori publications contributes to the understanding of treatment options and development trends worldwide.
    Keywords:  Helicobacter pylori; antibiotic resistance; antibiotics; treatment regimens
    DOI:  https://doi.org/10.2147/CEG.S342048
  37. Micromachines (Basel). 2022 Mar 20. pii: 476. [Epub ahead of print]13(3):
    Detecting the Knowledge Domains of Compound Semiconductors.
    Qian-Yo Lee, Chiyang James Chou, Ming-Xuan Lee, Yen-Chun Lee.
      The development of compound semiconductors (CS) has received extensive attention worldwide. This study aimed to detect and visualize CS knowledge domains for quantifying CS research patterns and emerging trends through a scientometric review based on the literature between 2011 and 2020 by using CiteSpace. The combined dataset of 24,622 bibliographic records were collected through topic searches and citation expansion to ensure adequate coverage of the field. While research in "solar cell" and "perovskite tandem" appears to be the two most distinctive knowledge domains in the CS field, research related to thermoelectric materials has grown at a respectable pace. Most notably, the deep connections between "thermoelectric material" and "III-Sb nanowire (NW)" research have been demonstrated. A rapid adaptation of black phosphorus (BP) field-effect transistors (FETs) and gallium nitride (GaN) transistors in the CS field is also apparent. Innovative strategies have focused on the opto-electronics with engineered functionalities, the design, synthesis and fabrication of perovskite tandem solar cells, the growing techniques of Sb-based III-V NWs, and the thermal conductivity of boron arsenide (BAs). This study revealed how the development trends and research areas in the CS field advance over time, which greatly help us to realize its knowledge domains.
    Keywords:  CiteSpace; compound semiconductors; knowledge domain; scientometrics
    DOI:  https://doi.org/10.3390/mi13030476
  38. Front Psychol. 2022 ;13 796069
    "Broad" Impact: Perceptions of Sex/Gender-Related Psychology Journals.
    Elizabeth R Brown, Jessi L Smith, Doralyn Rossmann.
      Because men are overrepresented within positions of power, men are perceived as the default in academia (androcentrism). Androcentric bias emerges whereby research by men and/or dominated by men is perceived as higher quality and gains more attention. We examined if these androcentric biases materialize within fields that study bias (psychology). How do individuals in close contact with psychology view psychology research outlets (i.e., journals) with titles including the words women, gender, sex, or feminism (sex/gender-related) or contain the words men or masculinity (men-related; Study 1) versus psychology journals that publish other-specialized research, and do these perceptions differ in the general public? While the men-related journal was less meritorious than its other-specialty journal, evidence emerged supporting androcentric bias such that the men-related journal was more favorable than the other sex/gender-related journals (Study 1). Further, undergraduate men taking psychology classes rated sex/gender-related versus other-specialty journals as less favorable, were less likely to recommend subscription (Studies 1-2), and rated the journals as lower quality (Study 2 only). Low endorsement of feminist ideology was associated with less support for sex/gender-related journals versus matched other-specialty journals (Studies 1-2). Decreased subscription recommendations for sex/gender-related journals (and the men-related journal) were mediated by decreased favorability and quality beliefs, especially for men (for the sex/gender-related journals) and those low in feminist ideology (Studies 1-2). However, we found possible androcentric-interest within the public sphere. The public reach of articles (as determined by Altmetrics) published in sex/gender-related was greater than other-specialty journals (Study 3). The consequences of these differential perceptions for students versus the public and the impact on women's advancement in social science and psychological science are discussed.
    Keywords:  androcentrism; gender; perceptions of sex/gender research; psychological research; sexism
    DOI:  https://doi.org/10.3389/fpsyg.2022.796069
  39. Ambio. 2022 Mar 23.
    The gulf of cross-disciplinary research collaborations on global river basins is not narrowed.
    Yongping Wei, Shuanglei Wu.
      Using publications in the Web of Science database (WoS), this study investigates the research collaboration on the top 95 most researched global river basins since 1900. The links of both the disciplines involved and the management issues studied between the biophysical, economic, societal, climatic and governance sub-systems of these river basins were examined. We found that research collaborations were dominated within the biophysical sub-system (65.3%) since the knowledge predevelopment period (1900-1983), with continuous increases (by 18.5%) during the rapid development (1984-2000) and the stabilisation (12.9% increase) (2001-2017). However, research collaborations related to the societal sub-system remained marginalised (varied at about 1%), while those related to the governance sub-system expanded in issues studied (32.8%) but were not supported by the core governance disciplines (3.4%). The key findings explained why global river basins are degraded from the perspective of knowledge development and they can assist the strategic planning and management of scientific research for improving governance capacity in modifying the relationship between human and nature on river basins in the Anthropocene. Tackling challenges in the Anthropocene requires transformation of the current pattern of knowledge development, a revolution in the governance of science.
    Keywords:  Complex knowledge system; Cross-disciplinary research collaboration; Earth system science; Global river basin governance
    DOI:  https://doi.org/10.1007/s13280-022-01716-0
  40. J Womens Health (Larchmt). 2022 Mar 24.
    Does Journal Content in the Field of Women's Health Represent Women's Burden of Disease? A Review of Publications in 2010 and 2020.
    Laura Hallam, Amy Vassallo, Ana-Catarina Pinho-Gomes, Cheryl Carcel, Mark Woodward.
      Background: Historically, women's health has focused on reproductive health. However, noncommunicable and communicable diseases comprise much of the burden of disease in women. Methods: A quantitative analysis of the main health content of articles published in six women's health journals (WHJ) and five general medical journals (GMJ) in 2010 and 2020 was conducted to categorize the main medical area topics of published articles and the life stage under study. Findings were compared with the leading causes of disease in women according to the Global Burden of Disease (GBD) study. Results: There were 1483 articles eligible for analysis. In total, in WHJ, 44% of topics were reproductive health, increasing from 36% in 2010 to 49% in 2020, which was similar to GMJ. Noncommunicable disease was the next most addressed topic, with cancer being the major disease area covered. When compared with the GBD study, major disease areas such as infectious disease, cardiovascular disease, and musculoskeletal disorders were underrepresented as topics in women's health publications. Most articles that focused on a particular life stage were on pregnancy or the reproductive years, with very few articles on menopause. Conclusion: Women's health publishing remains largely focused on reproductive health topics, with few articles on many of the major causes of morbidity and mortality in women. Journals, researchers, funders, and research priority setters should embrace a broader view of women's health to effectively cover content that reflects the broad range of health issues impacting women across the life span.
    Keywords:  global burden of disease; noncommunicable disease; reproductive health; women's health
    DOI:  https://doi.org/10.1089/jwh.2021.0425
  41. Actas Dermosifiliogr. 2022 Feb 22. pii: S0001-7310(22)00159-4. [Epub ahead of print]
    Significant Contribution of Spanish Dermatology Toward Understanding COVID-19: A Bibliometric Study of PubMed-Indexed Articles.
    C Miñones-Ginarte, M Pereiro-Ferreirós, M Ginarte-Val.
      
    DOI:  https://doi.org/10.1016/j.ad.2022.01.029
  42. Actas Dermosifiliogr. 2021 Sep 29. pii: S0001-7310(21)00347-1. [Epub ahead of print]
    Alternative Metrics as an Impact Measure for Dermatology Journals.
    J Ordoñez-Parra, D G Fernández-Ávila, I Cuellar-Ríos, D Patino-Hernandez.
      
    DOI:  https://doi.org/10.1016/j.ad.2020.04.019
  43. Medicines (Basel). 2022 Feb 28. pii: 18. [Epub ahead of print]9(3):
    The Impact of Industry Funding on Randomized Controlled Trials of Biologic Therapies.
    Aaron M Gazendam, David Slawaska-Eng, Nicholas Nucci, Om Bhatt, Michelle Ghert.
      Background: There has been substantial interest from the pharmaceutical industry to study and develop new biologic agents. Previous studies outside of the biologics field have demonstrated that industry funding has the potential to impact the design and findings of clinical trials. The objective of this study was to evaluate the impact of industry funding on randomized controlled trials (RCTs) that investigated the efficacy of biologic therapies. Methods: A review of all RCTs involving biologic therapies in top impact factor medical journals from January 2018 to December 2020 was performed. The relationship between industry funding and the presence of statistically significant primary outcomes and the use of active comparators were analyzed. Results: Among the 157 RCTs included, 120 (76%) were industry funded and 37 (24%) declared no industry funding. Industry-funded studies were significantly more likely to report a statistically significant positive primary outcome compared to studies without industry funding (85% vs. 67%, χ2 = 5.867, p = 0.015) and were significantly more likely to utilize placebo or no comparator than non-industry-funded trials (78% vs. 49%, χ2 = 4.430, p = 0.035). Conclusions: Industry-funded trials investigating biologic therapies are more likely to yield statistically significant positive outcomes and use placebo comparators when compared to non-industry-funded biologic therapy trials in high-impact medical journals.
    Keywords:  bias; biologics; immunotherapy; industry funding; monoclonal antibodies; randomized controlled trials
    DOI:  https://doi.org/10.3390/medicines9030018
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