bims-evares Biomed News
on Evaluation of research
Issue of 2022–10–02
79 papers selected by
Thomas Krichel, Open Library Society



  1. Neuropsychiatr Dis Treat. 2022 ;18 2107-2119
       Objective: This study aimed to analyze research on epilepsy in autism and autism in epilepsy using VOSviewer and CiteSpace to identify research hotspots and future directions.
    Methods: We searched the Web of Science Core Collection (WoSCC) for relevant studies about epilepsy in autism and autism in epilepsy published from inception to 31 May 2022. VOSviewer and CiteSpace were used to analyze the authors, institutions, countries, publishing journals, reference co-citation patterns, keyword co-occurrence, keyword clustering, keywords with citation bursts, and other aspects to construct a knowledge atlas.
    Results: A total of 473 publications related to epilepsy/autism were retrieved. The number of publications about epilepsy/ASD has generally increased over time, with some fluctuations. The USA (202 papers) and University of California-Los Angeles (15 papers) were the leading country and institution, respectively, in this field. Frye, Richard E. was the most published author (9 papers). Notably, collaboration between institutions, countries, and authors does not appear to be active. Hot topics and research frontiers include intellectual disability and exploring the mechanism of epilepsy/ASD from a genetics perspective.
    Conclusion: This analysis identified the most influential publications, authors, journals, institutions, and countries in the field of epilepsy/ASD research. Using co-occurrence and evolution analyses, the status of the field was identified and future trends were predicted.
    Keywords:  CiteSpace; VOSviewer; autism; bibliometrics; epilepsy; visualization analysis
    DOI:  https://doi.org/10.2147/NDT.S378372
  2. Front Surg. 2022 ;9 976546
       Background: The Coronavirus disease-2019 (COVID-19) significantly affected the healthcare and research systems, including spine surgery, throughout the world. A bibliometric analysis allows graphical visualization of the development of an academic field and its frontiers. Since research concerning spine surgery during the COVID-19 pandemic is being constantly upgraded, we conducted a bibliometric analysis of this literature to investigate the current status, research hotspots, and trends in this field.
    Methods: We searched the Web of Science database for literature published (from December 1, 2019, to March 24, 2022) using the terms "COVID-19" OR "2019-nCoV" OR "SARS-CoV-2" AND "spine surgery" OR "spinal surgery" OR "discectomy" OR "decompression" OR "laminectomy" OR "interbody fusion" OR "pedicle screws." Detailed bibliometric and visual analysis of the number of publications, geographical distribution, institutions, journals, authors, and keywords was done using CiteSpace, VOSviewer, and R-Bibliometrix.
    Results: Of the initially screened 173 articles, we included 84 relevant articles-62 original articles, 10 editorial materials, 8 reviews, and 4 others. The United States, China, Egypt, and Argentina were most actively publishing in the field of spine surgery and COVID-19. The AOSpine International community contributed 7 articles (24 citations). The Hospital for Special Surgery (13.1%) and Johns Hopkins University (13.1%) were institutions with the most publications. Using the Law of Bradford, we found that World Neurosurgery, Global Spine Journal, and European Spine Journal are the core journals in this field, with P. K. Louie being the most influential author. "Elective surgery," "intensive care," "telehealth," "patient satisfaction," and "follow-up" had the strongest citation bursts.
    Conclusions: During the COVID-19 pandemic, spine surgeons were more concerned with surgical timing, care, treatment, and patient's quality of life. Accordingly, research hotspots in spine surgery during the pandemic shifted from "early healthcare" to "virus management" and "experience and education."
    Keywords:  COVID-19; SARS-CoV-2; bibliometric analysis; research trends; spine surgery
    DOI:  https://doi.org/10.3389/fsurg.2022.976546
  3. Front Surg. 2022 ;9 976708
       Background: The numerous benefits of unilateral biportal endoscopic (UBE) spine surgery have attracted the attention of many researchers, and a considerable number of relevant clinical studies have been published. However, global research trends in the field of UBE have received little attention. The purpose of this study was to apply bibliometric method to analyze the UBE-related publications to obtain an overview of the research trends in the field of UBE, as well as research hotspots and trends.
    Methods: Web of Science database was searched for articles published until January 31, 2022. CiteSpace was used to analyze the data, which provided graphical knowledge maps. The following factors were applied to all literature: number of publications, distribution, h-index, institutions, journals, authors, and keywords.
    Results: Seventy-three articles were identified. Since 2019, there has been a significant increase in the number of UBE-related publications. The country with the largest number of articles was South Korea (72.6%), followed by China (9.6%), Japan (4.1%), and Egypt (4.1%). South Korea had the highest h-index (16), followed by China (2), Japan (1), and Egypt (1). Leon Wiltse Memorial Hospital was the organization that produced the most papers (12 publications). Heo DH was the most productive author (16 papers) and was the most cited author (35 times). World Neurosurgery published the most papers on UBE (23.3%). The main research hotspots were spinal diseases, decompression, complications, learning curve, and interbody fusion. In addition, the recent concerns were "learning curve," "interbody fusion," "management," and "dural tear."
    Conclusions: The quantity of publications on UBE research will increase, and South Korea being the major contributor and most prominent country in this field. The findings of our study will provide researchers with practical information on the field of UBE, and identification of mainstream research directions and recent hotspots.
    Keywords:  bibliometric analysis; biportal endoscopic spine surgery; research trends; unilateral biportal endoscopic; visualization
    DOI:  https://doi.org/10.3389/fsurg.2022.976708
  4. Front Aging Neurosci. 2022 ;14 984705
       Objective: Alzheimer's disease (AD) is a socially significant neurodegenerative disorder among the elderly worldwide. An increasing number of studies have revealed that as a non-pharmacological intervention, exercise can prevent and treat AD. However, information regarding the research status of this field remains minimal. Therefore, this study aimed to analyze trends and topics in exercise and AD research by using a bibliometric method.
    Methods: We systematically searched the Web of Science Core Collection for published papers on exercise and AD. The retrieved data regarding institutions, journals, countries, authors, journal distribution, and keywords were analyzed using CiteSpace software. Meanwhile, the co-occurrence of keywords was constructed.
    Results: A total of 1,104 papers were ultimately included in accordance with our specified inclusion criteria. The data showed that the number of published papers on exercise and AD is increasing each year, with papers published in 64 countries/regions and 396 academic journals. The Journal of Alzheimer's Disease published the most papers (73 publications). Journals are concentrated in the fields of neuroscience and geriatrics gerontology. The University of Kansas and the United States are the major institution and country, respectively. The cited keywords show that oxidative stress, amyloid beta, and physical exercise are the research hotspots in recent years. After analysis, the neuroprotective effect of exercise was identified as the development trend in this field.
    Conclusions: Based on a bibliometric analysis, the number of publications on exercise and AD has been increasing rapidly, especially in the past 10 years. "Amyloid beta," "oxidative stress," and "exercise program" trigger the most interest among researchers in this field. The study of exercise program and mechanism of exercise in AD is still the focus of future research.
    Keywords:  Alzheimer’s disease; CiteSpace; bibliometrics; exercise; visualized analysis
    DOI:  https://doi.org/10.3389/fnagi.2022.984705
  5. Front Aging Neurosci. 2022 ;14 977100
       Objective: To conduct a bibliometric analysis of trends and frontiers on exercise-based non-pharmacological treatments for movement disorders published between 2010 and 2021.
    Methods: The Web of Science (WOS) Core Collection database was searched for articles published between 2010 and 2021. The CiteSpace software was used for in-depth analysis of the countries, institutions, journals, and collaboration networks among authors and their types of articles, developmental directions, references, and hot keywords of published articles.
    Results: A total of 2,626 published articles were retrieved by search formula and included in the analysis. The number of publications fluctuated during this period, with 96 countries, 3,058 institutions, and 886 academic journals having published articles in this area, with subject classifications that focused on Clinical Neurology and Neurosciences. The United States has maintained its dominant and most influential position in exercise-based non-pharmacological research on movement disorders. Among research institutions and journals, the League of European Research Universities and Movement Disorders journals published the highest number of academic articles. In the last five years, the hot research topics by burst keyword analysis, are focused on treatments, research advances, and clinical treatments.
    Conclusion: Research on exercise-based non-pharmacological treatments for movement disorders is generally on the rise from 2010 to 2021. The bibliometric analysis of this area will help provide potential collaborations among researchers, frontiers, and directions for development.
    Keywords:  bibliometrics; exercise; frontier hotspots; movement disorders; non-pharmacological treatment; visualization
    DOI:  https://doi.org/10.3389/fnagi.2022.977100
  6. Front Med (Lausanne). 2022 ;9 995873
       Background: Over the last several decades, our understanding of hidradenitis suppurativa (HS) has improved considerably, thereby enhancing our ability to clinically diagnose and treat the disease.
    Objective: The purpose of this study was to identify and analyze the top 100 most-cited publications related to HS to update bibliometric information on HS.
    Materials and methods: We used the Web of Science database to identify reports on hidradenitis suppurativa. Data from the 100 most-cited publications were extracted and analyzed.
    Results: The citation number of the top 100 most-cited articles was 89-532 (mean, 153.51), with the most productive periods being from years 2007 to 2016. Most publications originated from the British Journal of Dermatology and the Journal of the American Academy of Dermatology. The 100 articles originated from 18 countries, with Denmark being the most productive country, followed by the United States (17), England (14), and Germany (12). Jemec GB, from the University of Copenhagen, had 32 citations and was the most frequently identified author. The 100 articles encompassed several fields of research as follows: pathogenesis (18%), pathophysiology (7%), epidemiology (14%), clinical diagnosis and features (16%), treatment (25%), comorbidity (10%), and others (10%). In total, 11 reviews, three guidelines, and 86 original articles (nine randomized clinical trials) were included.
    Conclusion: Through this bibliometric analysis, we aimed to indicate a series of intellectual landmark publications that offer us critical reviews, guidelines, and original articles, which highlight the immense level of progress achieved in the field of HS.
    Keywords:  bibliometric analysis; citation; hidradenitis suppurativa; most-cited publications; web of science
    DOI:  https://doi.org/10.3389/fmed.2022.995873
  7. Front Pharmacol. 2022 ;13 952211
      Background: NLRP3 inflammasome has been of great interest in the field of neurological diseases. To visualize the research hotspots and evolutionary trends in this area, we collected the relevant articles in the Web of Science Core Collection database from 2010 to 2022 and analyzed them using CiteSpace software. Methods: We performed a systematic search of the literature within the Web of Science Core Collection database using the strategy described below: TS = NLRP3 inflammasome AND TS = neurological diseases OR TS = neurological disorder OR TS = brain disorder OR TS = brain injury OR TS = central nervous system disease OR TS = CNS disease OR TS = central nervous system disorder OR TS = CNS disorder AND Language = English from 2010 to 2022. The type of literature was limited to articles and reviews. The data were processed using CiteSpace software (version 5.8. R3). Results: A total of 1,217 literature from 67 countries/regions and 337 research institutions was retrieved. Publications in this area have increased rapidly since 2013. China presents the highest number of published articles, but the United States has a higher centrality and h-index. The top five most published institutions and authors are from China, Zhejiang University and Li Y ranking first, respectively. Of the ten most cited articles, Prof. Heneka MT and colleagues accounted for three of them. In terms of the co-occurrence keyword diagram, the five most frequent keywords are "nlrp3 inflammasome", "activation", "oxidative stress", "expression", and "alzheimers disease". Conclusion: The research of NLRP3 inflammasome in neurological disorders is overall developing well. Chinese scholars contributed the most significant number of articles, while researchers from developed countries presented more influential papers. The importance of NLRP3 inflammasome in neurological diseases is widely appreciated, and the mechanism is under study. Moreover, NLRP3 inflammasome is emerging as a promising therapeutic target in treating neurological disorders. However, despite decades of research, our understanding of NLRP3 inflammasome in central nervous system diseases is still lacking. More and more profound research is needed in the future.
    Keywords:  NLRP3 inflammasome; hot spots; inflammation; neurological diseases; trend; visualization analysis
    DOI:  https://doi.org/10.3389/fphar.2022.952211
  8. Front Neurosci. 2022 ;16 959936
      Olfactory dysfunction (OD) accompanied by depression or anxiety is a very common clinical problem, and there has been a growing number of studies on OD with depression or anxiety in recent decades. This study performed bibliometric and visual analyses of the literature on OD with depression or anxiety to derive research trends and identify emerging research foci. Relevant publications were obtained from the Science Citation Index-Expanded and Social Sciences Citation Index in the Web of Science Core Collection databases (2002-2021). CiteSpace and VOSviewer were applied to identify and evaluate research foci and emerging trends in this research domain. The analyses found that the number of publications related to OD with depression or anxiety has increased significantly over the past 20 years, up from 15 in 2002 to 114 in 2022. The country that ranked highest in the number of articles and international cooperation was the United States. The top 10 most frequent keywords were "depression," "olfaction," "anxiety," "dysfunction," "olfactory bulbectomy," "olfactory dysfunction," "Parkinson's disease," "odor identification," "brain," and "disorders." Analysis of keywords with the strongest citation bursts revealed that "oxidative stress" is an emerging research hotspot. A timeline chart of the cluster of co-cited references demonstrated that Parkinson's disease was always a topic of interest in this area of research. This study conducted an objective, comprehensive, and systematic analysis of these publications, and identified the development of trends and hotspots in this research domain. It is hoped that this work will provide scholars, worldwide, with information to assist them in further research and the development of new therapies.
    Keywords:  anxiety; bibliometric analysis; depression; olfactory dysfunction; visual analysis
    DOI:  https://doi.org/10.3389/fnins.2022.959936
  9. Clin Exp Med. 2022 Sep 27.
      Bibliometric analysis is helpful to determine the most influential studies in a specific field. A large number of publications in anaphylaxis have been published. However, no bibliometric analysis of anaphylaxis was conducted based on our known. The aim of this study is to identify the top 100 most cited articles in anaphylaxis and analyze their bibliometric characteristics. We searched in the Web of Science core database on November 20, 2021. Articles were listed in descending order by their total citations. Hence the top 100 most cited articles in anaphylaxis were identified and analyzed. Bibliometric indicators included: year of publication, total number of citations and average citations per year (ACY), journal of publication and impact factor (IF), countries, institutes, and authors, which were analyzed by Biblioshiny. Co-occurrence was used to visualize the classification and hotspots. The top 100 most cited articles were published between 1991 and 2017. The largest number of articles was published in a single interval in 2006-2008. Total citations of the 100 articles were between 155 and 1241 and were positively correlated with the number of articles published in each 3-year interval. The top100 articles were published in 34 different journals. The Journal of Allergy and Clinical Immunology published the most (n = 41). The corresponding authors of the top100 articles were from 13 different countries, mostly in North America and Europe. Statistical analysis revealed a positive correlation between total number of citations and ACY (r = 0.670, p < 0.01) and between total number of citations and IF (r = 0.219, p < 0.05), whereas a negative correlation between ACY and length of time since publication (r = - 0.697, p < 0.01). The research focuses were classified into three clusters: (1) the epidemiology and management. (2) the risk factor and treatment. (3) the assessment and diagnosis. COVID-19 vaccines, drug allergy and management were the recent major topics. This bibliometric analysis reveals the progress and hotspots of research in anaphylaxis, which may lay a foundation for further research.
    Keywords:  Anaphylaxis; Bibliometric analysis; Biblioshiny
    DOI:  https://doi.org/10.1007/s10238-022-00890-5
  10. Rheumatol Int. 2022 Sep 27.
      Idiopathic inflammatory myopathy is a multisystem autoimmune condition characterized by muscle inflammation (myositis) and interstitial lung disease (ILD). Bibliometric analysis and altmetric analysis are effective methods of evaluating academic productivity and measuring the influence of publications. The purpose of this study is to analyze the research productivity and influence of idiopathic inflammatory myopathy articles using bibliometric analysis and altmetric analysis. Data from articles published between 2011 and 2021 were obtained from the Web of Science. Altmetric attention scores and Mendeley reader counts of the articles were obtained from altmetric evaluations. In the study, 2060 articles related to idiopathic inflammatory myopathy were screened out showing an increasing trend in general. In terms of the origin countries of articles, the United States (n = 467, 22.67%) ranked first. Johns Hopkins University has the largest number of institutions (n = 113). The journals regarding idiopathic inflammatory myopathy and Rheumatology (n = 87) published the most articles. The most cited article was published by Mammen et al. and was related to autoantibodies. Dermatomyositis, polymyositis and other research hotspots were represented by keywords. The results of the altmetric analysis showed that citations, impact factors and h-index were significantly correlated with Altmetric Attention Scores and Mendeley Readers Count (P < 0.05). In summary, bibliometric analysis summarizes the current status of idiopathic inflammatory myopathy research and helps to understand the development of idiopathic inflammatory myopathy in the field between 2011 and 2021. Altmetric analysis was used to evaluate the academic and social influence of articles from the novel perspective of internet attention.
    Keywords:  Altmetric; Bibliometric analysis; Idiopathic inflammatory myopathy; Web of Science
    DOI:  https://doi.org/10.1007/s00296-022-05211-3
  11. Front Cell Infect Microbiol. 2022 ;12 1005730
       Background: There is a crosstalk between traditional Chinese medicine (TCM) and gut microbiota (GM), many articles have studied and discussed the relationship between the two. The purpose of this study is to use bibliometric analysis to explore the research status and development trends of the TCM/GM research, identify and analyze the highly cited papers relating to the TCM/GM.
    Methods: A literature search regarding TCM/GM publications from 2004 to 2021 was undertaken on August 13, 2022. The main information (full record and cited references) of publications was extracted from the Science Citation Index Expanded (SCI-E) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package, CiteSpace and VOSviewer were used for bibliometric analysis.
    Results: A total of 830 papers were included. The publication years of papers were from 2004 to 2021. The number of papers had increased rapidly since 2018. China had the most publications and made most contributions to this field. Nanjing University of Chinese Medicine and Beijing University of Chinese Medicine were in the leading productive position in TCM/GM research, Chinese Academy of Chinese Medical Sciences had the highest total citations (TC). Duan Jin-ao from Nanjing University of Chinese Medicine had the largest number of publications, and Tong Xiao-lin from China Academy of Chinese Medical Sciences had the most TC. The Journal of Ethnopharmacology had the most published papers and the most TC. The main themes in TCM/GM included the role of GM in TCM treatment of glucolipid metabolism diseases and lower gastrointestinal diseases; the mechanism of interactions between GM and TCM to treat diseases; the links between TCM/GM and metabolism; and the relationship between GM and oral bioavailability of TCM.
    Conclusion: This study gained insight into the research status, hotspots and trends of global TCM/GM research, identified the most cited articles in TCM/GM and analyzed their characteristics, which may inform clinical researchers and practitioners' future directions.
    Keywords:  bibliometrics; correlation; gut microbiota; highly cited papers; research status and trends; traditional Chinese medicine
    DOI:  https://doi.org/10.3389/fcimb.2022.1005730
  12. Front Hum Neurosci. 2022 ;16 981571
       Background: Diagnostic ultrasound has long been a part of a physician's armamentarium, but transcranial focused ultrasound (FUS) is an emerging treatment of neurological disorders. Consequently, the literature in this field is increasing at a rapid pace.
    Objective: This analysis was aimed to identify the top-cited articles on FUS to discern their origin, spread, current trends highlighting future impact of this novel neurosurgical intervention.
    Methods: We searched the Web of Science database on 28th May 2021 and identified the top 100 cited articles. These articles were analyzed with various scientometric parameters like the authors, corresponding authors, country of corresponding author, journal of publication, year of publication. Citation based parameters including total citations, mean citations per article and mean citations, citation count, and the citation per year, citations per year and co-authors per document were studied as well in addition to Hirsch h-index, g-index, m-index, Bradford's Law, Lotka's law and Collaboration index.
    Results: The 100 top-cited articles were published between 1998 and 2019 in 45 different journals. The average citations per document and citations per document per year were 97.78 and 12.47, respectively. The most prolific authors were Hynynen K (Medical Biophysics-Toronto), Elias WJ (Neurosurgery-Virginia), Zadicario (InSightec). The Journal of Neurosurgery published the most top-cited articles (n = 11), and most articles originated from the United States, followed by Canada. Among individual institutions, the University of Toronto was the most productive.
    Conclusion: FUS is an emerging treatment of neurological disorders. With its increasing application, the FUS literature is increasing rapidly. Eleven countries contributed to the top 100 cited articles, with the top 2 countries (the United States and Canada) contributing to more than half of these articles.
    Keywords:  FUS; MRI; Parkinson’s disease; essential tremor; focused ultrasound; neurosurgery
    DOI:  https://doi.org/10.3389/fnhum.2022.981571
  13. Front Immunol. 2022 ;13 903771
      Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by macrophage activation. The current characteristics, hotspots, and research frontiers of macrophage-related RA were analyzed using bibliometric analysis. Relatedpapers published from 2000 to 2021 in the Web of Science database were retrieved. The diagrams were generated and analyzed using the bibliometric software package. VOSviewer and CiteSpace were used to evaluate and visualize the research trends and hotspots in macrophage-related RA. A total of 7253 original articles were obtained. Global research on macrophage-related RA is in an advanced stage of development, with core authors, teams and research institutions emerging. United States has published the most papers, received the most citations, and had the highest H-index over the last 22 years. The University of Amsterdam and the journal of Arthritis and Rheumatism are the most productive research institutions and journals. Tak PP's (St Vincent's Hospital) paper has the highest publication and citation scores. The keywords "bone loss" and "polarization" have the highest frequency. Additionally, the study of macrophage polarization in RA has been research focus in recent years. This study demonstrates that research on macrophages in RA will continue. China is a significant producer, whereas the United States is an influential nation in this regard. In the last decade, most studies have concentrated on fundamental research. Recent studies have shown how macrophages play a role in controlling and weakening inflammation, and drug delivery and mechanism have come to the fore.
    Keywords:  bibliometrics; hotspots; macrophages; research status; rheumatoid arthritis
    DOI:  https://doi.org/10.3389/fimmu.2022.903771
  14. Front Oncol. 2022 ;12 965773
       Objective: To illustrate the knowledge hotspots and cutting-edge research trends of 18F-FDG PET/CT radiomics, the knowledge structure of was systematically explored and the visualization map was analyzed.
    Methods: Studies related to 18F-FDG PET/CT radiomics from 2013 to 2021 were identified and selected from the Web of Science Core Collection (WoSCC) using retrieval formula based on an interview. Bibliometric methods are mainly performed by CiteSpace 5.8.R3, which we use to build knowledge structures including publications, collaborative and co-cited studies, burst analysis, and so on. The performance and relevance of countries, institutions, authors, and journals were measured by knowledge maps. The research foci were analyzed through research of keywords, as well as literature co-citation analysis. Predicting trends of 18F-FDG PET/CT radiomics in this field utilizes a citation burst detection method.
    Results: Through a systematic literature search, 457 articles, which were mainly published in the United States (120 articles) and China (83 articles), were finally included in this study for analysis. Memorial Sloan-Kettering Cancer Center and Southern Medical University are the most productive institutions, both with a frequency of 17. 18F-FDG PET/CT radiomics-related literature was frequently published with high citation in European Journal of Nuclear Medicine and Molecular Imaging (IF9.236, 2020), Frontiers in Oncology (IF6.244, 2020), and Cancers (IF6.639, 2020). Further cluster profile of keywords and literature revealed that the research hotspots were primarily concentrated in the fields of image, textural feature, and positron emission tomography, and the hot research disease is a malignant tumor. Document co-citation analysis suggested that many scholars have a co-citation relationship in studies related to imaging biomarkers, texture analysis, and immunotherapy simultaneously. Burst detection suggests that adenocarcinoma studies are frontiers in 18F-FDG PET/CT radiomics, and the landmark literature put emphasis on the reproducibility of 18F-FDG PET/CT radiomics features.
    Conclusion: First, this bibliometric study provides a new perspective on 18F-FDG PET/CT radiomics research, especially for clinicians and researchers providing scientific quantitative analysis to measure the performance and correlation of countries, institutions, authors, and journals. Above all, there will be a continuing growth in the number of publications and citations in the field of 18F-FDG PET/CT. Second, the international research frontiers lie in applying 18F-FDG PET/CT radiomics to oncology research. Furthermore, new insights for researchers in future studies will be adenocarcinoma-related analyses. Moreover, our findings also offer suggestions for scholars to give attention to maintaining the reproducibility of 18F-FDG PET/CT radiomics features.
    Keywords:  18F-FDG; PET/CT; bibliometric analysis; hot topics; radiomics
    DOI:  https://doi.org/10.3389/fonc.2022.965773
  15. Front Pharmacol. 2022 ;13 1001861
      Background: Bacterial persisters are thought to be responsible for the recalcitrance and relapse of persistent infections, and they also lead to antibiotic treatment failure in clinics. In recent years, researches on bacterial persisters have attracted worldwide attention and the number of related publications is increasing. The purpose of this study was to better understand research trends on bacterial persisters by identifying and bibliometrics analyzing the top 100 cited publications in this field. Methods: The Web of Science Core Collection was utilized to retrieve the highly cited publications on bacterial persisters, and these publications were cross-matched with Google Scholar and Scopus. The top 100 cited publications were identified after reviewing the full texts. The main information of each publication was extracted and analyzed using Excel, SPSS, and VOSviewer. Results: The top 100 cited papers on bacterial persisters were published between 1997 and 2019. The citation frequency of each publication ranged from 147 to 1815 for the Web of Science Core Collection, 153 to 1883 for Scopus, and 207 to 2,986 for Google Scholar. Among the top 100 cited list, there were 64 original articles, 35 review articles, and 1 editorial material. These papers were published in 51 journals, and the Journal of Bacteriology was the most productive journal with 8 papers. A total of 14 countries made contributions to the top 100 cited publications, and 64 publications were from the United States. 15 institutions have published two or more papers and nearly 87% of them were from the United States. Kim Lewis from Northeastern University was the most influential author with 18 publications. Furthermore, keywords co-occurrence suggested that the main topics on bacterial persisters were mechanisms of persister formation or re-growth. Finally, "Microbiology" was the most frequent category in this field. Conclusion: This study identified and analyzed the top 100 cited publications related to bacterial persisters. The results provided a general overview of bacterial persisters and might help researchers to better understand the classic studies, historical developments, and new findings in this field, thus providing ideas for further research.
    Keywords:  VOSviewer; bacterial persisters; bibliometric analysis; citation analysis; top-cited
    DOI:  https://doi.org/10.3389/fphar.2022.1001861
  16. Front Immunol. 2022 ;13 978552
       Background: Pyroptosis is a lytic pro-inflammatory programmed cell death mode that depends on caspase, inflammasome, and Gasdermin D (GSDMD). A growing number of studies have shown that pyroptosis is closely related to the pathophysiological mechanism of lung. The purpose of this study is to analyze the literature from Science Citation Index Expanded (SCI-expanded) of Web of Science Core Collection (WoSCC) and visualize the current trends and hotspots in the research of pyroptosis in lung disease.
    Methods: On February 20, 2022, we retrieved all articles on pyroptosis in lung disease from SCI-expanded of WoSCC. Original articles and reviews published in English from 2007 to 2021 were included in the analysis. VOSviewer 1.6.17 and CiteSpace 5.8.R2 were used to analyze the retrieved data and visualize the results.
    Result: 1798 qualified original articles and reviews on pyroptosis in lung disease were included in the bibliometric analysis. So far, the research in this field is still in a period of growth, and the number of global publications has increased yearly. Among the 66 countries that have published relevant articles, China ranked first in the number of publications, and the USA ranked first in the number of cited articles. Holian,A. was the author with the largest number of articles, including 21 published. The University of California System in the USA was the organization with the largest number of articles, totaling 55. Frontiers in Immunology was the journal with the most publications in pyroptosis. After bibliometric analysis, the frequently used keywords are: "NOD-like receptor3 (NLRP3) inflammasome", "inflammation", "oxidative stress", and "acute lung injury (ALI)".
    Conclusion: The research on pyroptosis in lung disease is in its growth stage. The information released in this article may help researchers better understand the hotspots and developmental trends in this field, the cooperation network information of authors, countries, and institutions, and the citation correlation between articles. With the in-depth study of the mechanism of pyroptosis, the focus has shifted to increasing research on the connections and influences of different diseases. So far, increasing attention has been paid to the research field of the relationship between ALI and pyroptosis related to COVID-19.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; lung; pyroptosis
    DOI:  https://doi.org/10.3389/fimmu.2022.978552
  17. Medicine (Baltimore). 2022 Sep 30. 101(39): e30850
      Whiplash injury is a common diagnosis and causes substantial economic burden. Numerous papers have been published to provide new insights into whiplash injury. However, so far there has not been a comprehensive analysis of the most influential publications on whiplash injury. This study aimed to determine the 100 most cited publications on whiplash injury and analyze their characteristics. A keyword search was conducted using the Web of Science database. The top 100 cited publications relevant to whiplash injury were gathered. The main characteristics including title, year of publication, citation, authorship, journal, country, institution, and topic were generated. The number of citations of the top 100 cited publications ranged from 82 to 777. Fifteen countries contributed the top 100 publications. Australia had the largest number of publications (26), followed by the United States (21), and Canada (12). The majority of the publications were from Europe (40) and North America (33). A total of 19 institutions and 17 authors published more than one publication. The University of Queensland (16) and the author Sterling M (7) had the leading publication record. This is the first citation analysis to identify and characterize the highest impact researches on whiplash injury. The present analysis provides the most influential studies on whiplash injury, and reveals the leading journals, counties, institutions, and authors with special contributions in this filed. The list may serve as an archive of historical development of whiplash injury and a basis for further research.
    DOI:  https://doi.org/10.1097/MD.0000000000030850
  18. Medicine (Baltimore). 2022 Sep 30. 101(39): e30858
       BACKGROUND: Acupuncture and moxibustion (AM) are utilized to treat Alzheimer's disease (AD). However, no bibliometric analysis has explored this issue. Thus, this study investigated the status, hotspots and trends of AM in the treatment of AD.
    METHODS: CiteSpace and VOSviewer softwares were used to analyze the literature on the AM for AD in the Web of Science Core Collection database. We analyzed the data of countries/regions, institutions, journals, authors, keywords, and cited references.
    RESULTS: After removing duplicates, 193 articles were retrieved. The number of publications on this topic has increased gradually. The most productive and collaborative country was China (143 documents), followed by South Korea (19). The top 3 active academic institutions were Beijing University of Chinese Medicine, Capital Medicine University, and Guangzhou University of Chinese Medicine. The most productive journal was Evidence-based Complementary and Alternative Medicine (13 documents), followed by the Frontiers in Aging Neuroscience (10), Medicine (10), and Neural Regeneration Research (10). The top 3 co-cited journals were Evidence-based Complementary and Alternative Medicine (156 citations), Acupuncture Electro-therapeutics Research (152), and Acupuncture in Medicine (146). The research hotspots in this domain are dementia, memory, hippocampus, mouse models, and Parkinson's disease. Major frontiers are comparing the therapeutic effects of acupuncture and donepezil and electroacupuncture at different frequencies in this field.
    CONCLUSION: This bibliometric study identified relevant hotspots and trends in research on AM in the treatment of AD, which can provide researchers with key information in this domain and help further explore new research directions.
    DOI:  https://doi.org/10.1097/MD.0000000000030858
  19. World J Gastroenterol. 2022 Sep 07. 28(33): 4909-4919
       BACKGROUND: Liver cirrhosis is the leading cause of liver-related mortality worldwide. It is currently a global health challenge.
    AIM: This research intended to explore and analyse research trends and frontiers in this field during the last 10 years, providing new inspiration for clinical decision-making and scientific research.
    METHODS: Publications on hepatic cirrhosis research were retrieved from the Web of Science Core Collection on April 4, 2021. Bibliometric visualisation was conducted through VOSviewer and CiteSpace.
    RESULTS: The analytic research was based on original articles and reviews. A total of 7775 records of hepatic cirrhosis published from 2011 to 2020 were retrieved. In the past ten years, the number of related annual publications has increased significantly, especially in the United States and China. All publications were distributed among 109 countries. The United States contributed the most (21.95%) and was consistently the leading driving force, with a solid academic reputation in this area. The University of Barcelona distributed the most related articles (177 articles) and was cited the most frequently. The Journal of Hepatology ranked third in the top 10 journals, which has the highest impact factor (impact factor 2019 = 20.582). Jasmohan S. Bajaj was the most productive author (72 articles). Burst keywords (e.g., sofosbuvir, burden, care, sarcopenia, chronic liver failure, human gut microbiome, and nonalcoholic fatty liver disease) and a succession of reference citation bursts have provided clues about research frontiers in recent years.
    CONCLUSION: This study identified developing trends in the evolution of liver cirrhosis to provide new inspiration for researchers.
    Keywords:  Bibliometric research; CiteSpace; Liver cirrhosis; Research frontiers; VOSviewer; Visualization
    DOI:  https://doi.org/10.3748/wjg.v28.i33.4909
  20. Front Surg. 2022 ;9 944566
       Background: Meniscal root tears are one of the common diseases in the field of orthopedics and sports medicine today and are the subject of many current investigative efforts.
    Purpose: This study aims to identify and evaluate the global trends, hotspots and frontiers in meniscal root tear research using bibliometric analysis.
    Methods: A bibliometric analysis of research findings related to meniscal root tears over the past three decades was performed. CiteSpace was used to conduct document co-citation and cluster analyses on the collected data. The research was conducted based on the following factors: country and institution distribution, chronological distribution, source journal analysis, keyword co-occurrence analysis, and reference co-citation analysis.
    Results: A total of 626 research articles on meniscal root tears in English published from 1989 to 2021 were obtained. There was a significant upward trend in the total number of scientific publications over the past decades, especially in 2015-2020. The most productive countries, institutions, journals and authors are the USA, STEADMAN PHILIPPON, KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY , and LAPRADE RF. North America and East Asia made outstanding contributions to the research on meniscal root tears, but cooperation and exchanges between countries and institutions were not close enough. A total of 9 clusters were obtained from the citation analysis, and 8 clusters were obtained from the keyword analysis. The main keywords that ranked first were posterior root tear, medial meniscus, menisci tibial, and ACL reconstruction, and these clusters combined with the corresponding emergence reflected the current status of research at different times.
    Conclusion: Research in this field over the past 32 years has gone through a phase of exploration in the understanding of the anatomy of the meniscal root and the diagnosis of this disease and a phase of development with in-depth biomechanical studies and improved and innovative surgical techniques. The current research focuses on the innovation of meniscal root tear repair techniques, the long-term efficacy of surgery, the variability in the efficacy of different surgical techniques, and surgical strategies for combined injuries. There will be more breakthroughs in surgical techniques, surgical equipment and surgical materials to resolve meniscal root tears.
    Keywords:  CiteSpace; VOSviewer; meniscus; research hotspots; research status; root tear; web of science
    DOI:  https://doi.org/10.3389/fsurg.2022.944566
  21. Front Immunol. 2022 ;13 979675
       Background: Oxidative stress has been implicated in many chronic inflammatory diseases, including periodontitis. To date, however, only a few bibliometric analyses have systematically studied this field. This work sought to visualize research hot spots and trends in oxidative stress associated with periodontitis from 1987 to 2022 through bibliometric approaches.
    Methods: The Web of Science Core Collection was searched to retrieve relevant publications. HistCite, VOSviewer, and CiteSpace were used to perform bibliometric analysis visually in terms of annual output, active countries, prolific institutions, authors, core journals, co-cited references, and co-occurrence of keywords.
    Results: A total of 1654 documents were selected for analysis. From 1 January 1987 to 11 June 2022, the number of annual publications related to oxidative stress in periodontitis exhibited an upward trend. The most prolific country was China with 322 documents, but the United States had 11334 citations. Okayama University, University of Birmingham, and Sichuan University were the most active and contributive institutions. The Journal of Periodontology ranked first in terms of numbers of publications and citations. Ekuni was the most prolific author, while Chapple ranked first among co-cited authors. The Role of Reactive Oxygen and Antioxidant Species in Periodontal Tissue Destruction published by Chapple was the most frequently co-cited reference. Keywords co-occurrence showed that oxidative stress was closely related to inflammation, antioxidants, and diabetes.
    Conclusion: Our research found that global publications regarding research on oxidative stress associated with periodontitis increased dramatically and were expected to continue increasing. Inflammation and oxidative stress, and the relationship between periodontitis and systemic diseases, are topics worthy of attention.
    Keywords:  bibliometric analysis; data visualization; inflammation; oxidative stress; periodontitis
    DOI:  https://doi.org/10.3389/fimmu.2022.979675
  22. Front Psychiatry. 2022 ;13 968629
       Background: Perimenopausal depression (PMD) is characterized by affective symptoms as well as menopause-specific somatic complaints and has attracted increasing attention over the past few decades. Using a bibliometric tool, this study aims to evaluate the origin, current hotspots, and research trends on PMD.
    Methods: Articles with research on PMD were retrieved from Web of Science Core Collection (WoSCC). We used the bibliometric method to analyze publication years, journals, countries, institutions, authors, research hotspots, and trends. We plotted the reference co-citation network and used keywords to analyze the research hotspots and trends.
    Results: A total of 209 publications related to PMD were identified from WoSCC on May 8, 2022. The number of publications concerning PMD every year shows an upward trend. Further analysis indicated that 209 articles were contributed by 45 countries, 288 institutions, and 501 authors. The United States contributed the most significant number of publications, followed by China. Harvard University is the core institution of PMD research, and Cohen's work has had an important impact on another research. The occurrence and pathological mechanisms of depression during the menopausal transition from the knowledge base of PMD. All of them belong to the category of gynecology and psychosis, which reflects the focus of the research topics. Major depression, postmenopausal women, symptoms like hot flashes, and prevalence and risk factors are research hotspots in the PMD field. The frontiers in PMD field that will impact future research are anxiety, meta-analysis, association, and Beck Depression Inventory-II (BDI-II).
    Conclusion: These findings provide us with the core countries, institutions, and authors in PMD research and point out the direction of attention in this field. The current research focuses on depression, postmenopausal women, hot flashes, and other symptoms, as well as the prevalence and risk factors. The frontiers will be anxiety, meta-analysis, related factors, and depression assessment in future research.
    Keywords:  CiteSpace front psychiatry; knowledge domain; perimenopausal depression; trends; web of science
    DOI:  https://doi.org/10.3389/fpsyt.2022.968629
  23. J Pediatr Urol. 2022 Aug 30. pii: S1477-5131(22)00359-X. [Epub ahead of print]
      To assess the global research landscape in the field of Posterior urethral valve (PUV), a scientometric study was conducted to determine the quantity and quality of the research output and get insight into the key research areas and pattern of collaboration in the research community.
    METHODS: Primary data was acquired from the Scopus® database. Various parameters like the total research productivity, citations, citations per publication, citations per year, citations per publication per year, the scientific output of countries, institutions, authors, and journals were calculated. Key research areas were inferred by examining the top-cited articles (citations >150). Collaborative maps were generated by calculating co-authorship links amongst countries and authors using VOSviewer software.
    RESULTS: One thousand seven hundred fourteen results were found published from 1913 to 2019, receiving a total of 27,253 citations, authored by 5138 authors from 125 countries. The top three countries were the United States of America (USA), India, and the United Kingdom (UK). The leading institutes were the Children's Hospital Boston, USA (n = 48), All India Institute of Medical Sciences (AIIMS, Delhi), India (n = 38), and Great Ormond Street Hospital, UK (n- = 27). The journals which published the most articles on PUV were the Journal of Urology (n = 278), Journal of Pediatric Urology (n = 121), followed by Urology (n = 86). Leading authors were Glassberg, K. L and Bajpai M (n = 17, each), Canning DA & Kajbafzadeh, AM (n = 16, each), followed by Peters CA with 14 manuscripts. The top-cited documents (n = 10) received 2104 citations and were published between 1986 and 2010. The key areas of interest found were "long-term outcomes" (n = 4) and "fetal surgery" (n = 2). The most productive countries were also the most collaborative countries (the USA and UK).
    CONCLUSION: In the research landscape of PUV, the USA, Children's Hospital Boston, and Glassberg, K. L, along with Bajpai, M were the top contributors in terms of the country, organization, and authors, respectively. The "Journal of Urology" and "Pediatric Nephrology" stands out in terms of bibliometric parameters considered. The hotspot topics based on the number of citations received were "long-term outcomes" and "fetal surgery" in PUV. The most productive countries were also the most collaborative countries (the USA and UK).
    Keywords:  Bibliometrics; Co-authorship; Network map; Posterior urethral valve; Scopus®; VOSviewer
    DOI:  https://doi.org/10.1016/j.jpurol.2022.08.020
  24. Front Public Health. 2022 ;10 926244
       Background: Since the 2019 novel coronavirus (COVID-19) pneumonia outbreak in late 2019, an endless stream of research has emerged surrounding physical activity. This study analyzes the 50 most influential articles on COVID-19 and physical activity over the past 2 years to describe the research landscape and hotspots from bibliometric citation analysis.
    Methods: The top-50 cited articles were extracted from the Web of Science Core Collection database, and bibliometric citation analysis was performed by Excel 2019 and VOSviewer software.
    Results: The top-50 articles were cited 160.48 ± 106.90 (range: 70-587). Most of the articles were from the United States (14), followed by Italy (11) and England (9). The International Journal of Environmental Research and Public Health (n = 10) is the journal with the top-50 cited articles. The collaboration between authors was mainly among three teams, including Smith L, Musumeci G, and Napoli C. The hotspot of research around COVID-19 and physical activity focused on lifestyle change (sedentary behavior, sitting time), mental health (depressive, anxiety, loneliness), the credibility of physical activity assessment tools (reliability, validity), and physical activity of different populations (gender, youth, children).
    Conclusions: Based on a bibliometric analysis of high-impact articles on COVID-19 and physical activity highlights physical activity as an essential lifestyle change and developments and hotspots in this field. These data will provide insights for future researchers regarding the direction of physical activity research in the COVID-19 pandemic.
    Keywords:  COVID-19; bibliometric analysis; citation classics; physical activity; top-50
    DOI:  https://doi.org/10.3389/fpubh.2022.926244
  25. Front Nutr. 2022 ;9 973332
       Background: Vitamin D plays an invaluable role in reproductive health, but vitamin D insufficiency and deficiency are generally common among couples of childbearing age and pregnant women. This study aimed to evaluate the evolution, development trend, and research hotspot of publications on vitamin D and reproductive health.
    Methods: The literature on vitamin D and reproductive health between 2012 and 2021 was retrieved from the Web of Science Core Collection (WoSCC). We used VOSviewer and CiteSpace to analyze publication years, countries, institutions, journals, highly cited authors and publications, and co-occurrence and citation bursts of keywords.
    Results: A total of 1,828 articles and reviews on vitamin D and reproductive health published between 2012 and 2021 were identified. The annual publication outputs showed steady growth, with the most publications (272) and citations (7,097) in 2021. The United States contributed the most publications (458) and had the highest h-index (58). In terms of the number of publications and h-index, the journal named Nutrients ranked first. Nutrition dietetics, obstetrics gynecology, and endocrinology metabolism were three well-represented disciplines in research on vitamin D and reproductive health. Hollis BW, Wagner CL, and Litonjua AA were the top three most productive authors in this field during the last decade. Apart from vitamin D, the five keywords with the most frequent occurrence were vitamin D deficiency, pregnancy, risk, vitamin D supplementation, and 25-hydroxyvitamin D. Keyword citation burst analysis revealed that low birth weight, adipose tissue, marker, and embryo had a citation burst lasting until 2021.
    Conclusion: In conclusion, vitamin D has received continuous attention in the field of reproductive health, and there appears to have a higher level of research in North America. Multidisciplinary intersection contributed to the in-depth exploration in this field. And the effect of maternal vitamin D levels on fetal lipid metabolism and the prediction of fertility by vitamin D-related markers might be hotspots for the research.
    Keywords:  bibliometric analysis; marker; pregnancy; reproductive health; vitamin D; vitamin D deficiency
    DOI:  https://doi.org/10.3389/fnut.2022.973332
  26. Front Psychiatry. 2022 ;13 976827
       Background: Gastrointestinal (GI) symptoms can be observed in autism spectrum disorder (ASD) children. It is suggested that the gut microbiota and its metabolites are associated, not only with GI symptoms, but also with behaviors of ASD. The aim of this study was to explore the development context, research hotspots and frontiers of gut microbiota and ASD from January 1, 1980 to April 1, 2022 by bibliometric analysis.
    Materials and methods: Publications of ASD and gut microbiota research from 1 January 1980 to 1 April 2022 were retrieved from the Web of Science Core Collection (WoSCC). Publications and citations trends were analyzed by Excel 2010. CiteSpace was used to analyze countries/regions, authors, institutes, references, and keywords and to visualize the knowledge map.
    Results: A total of 1027 studies were retrieved, and 266 original articles were included after screening. The most published countries and institutes were the United States and King Saud University. Afaf El-Aansary published the most articles, while Finegold SM had the highest co-citations. Hotspots and emerging trends in this area may be indicated by co-cited references and keywords and their clusters, including "gut-brain axis," "behavior," "chain fatty acid," "brain," "feces," "propionic acid," "clostridium perfringens," and "species clostridium innocuum."
    Conclusion: The United States dominants the research in this field, which focuses on the alterations of gut microbiota composition and its metabolites, among which the roles of the genus Clostridium and metabolites of short-chain fatty acids, especially propionic acid, are priorities. Fecal microbiota transplantation (FMT) is a promising complementary therapy. In general, research in this area is sparse, but it still has great research prospects.
    Keywords:  CiteSpace; autism spectrum disorder; bibliometric analysis; data visualization; microbiota
    DOI:  https://doi.org/10.3389/fpsyt.2022.976827
  27. Multimed Tools Appl. 2022 Sep 19. 1-21
      Since its inception, YouTube has been a source of entertainment and education. Everyday millions of videos are uploaded to this platform. Researchers have been using YouTube as a source of information in their research. However, there is a lack of bibliometric reports on research carried out on this platform and the pattern in the published works. This study aims at providing a bibliometric analysis on YouTube as a source of information to fill this gap. Specifically, this paper analyzes 1781 articles collected from the Scopus database spanning fifteen years. The analysis revealed that 2006-2007 were initial stage in YouTube research followed by 2008 -2017 which is the decade of rapid growth in YouTube research. The 2017 -2021 is considered the stage of consolidation and stabilization of this research topic. We also discovered that most relevant papers were published in small number of journals such as New Media and Society, Convergence, Journal of Medical Internet Research, Computers in Human Behaviour and the Physics Teacher, which proves the Bradford's law. USA, Turkey, and UK are the countries with the highest number of publications. We also present network analysis between countries, sources, and authors. Analyzing the keywords resulted in finding the trend in research such as "video sharing" (2010-2018), "web -based learning" (2012-2014), and "COVID -19" (2020 onward). Finally, we used Multiple Correspondence Analysis (MCA) to find the conceptual clusters of research on YouTube. The first cluster is related to user -generated content. The second cluster is about health and medical issues, and the final cluster is on the topic of information quality.
    Keywords:  Bibliometric analysis; Co -citation networks; Keyword co -occurrence networks; YouTube
    DOI:  https://doi.org/10.1007/s11042-022-13908-7
  28. Heliyon. 2022 Sep;8(9): e10723
       Objectives: Wayfinding in complex environments is a public issue facing the world and has become a hot research topic in recent years. This article reviews and quantitatively analyzes the literature on wayfinding in healthcare facilities and collates the research trends and hotspots in this area.
    Methods: The article used bibliometric analysis to search keywords in the Scopus database in the TITLE-ABS-KEY format. In total, 2359 articles were finally collated between 1974 and 2020 after three screening exercises, and a co-citation analysis was conducted by VOSviewer literature visualization analysis software.
    Results: Research in the worldwide literature on wayfinding in healthcare facilities has grown steadily year on year since 2002. Computer science (21.5%) and social science (15.5%) are the most common subject categories, with the United States (N = 767) accounting for the largest proportion of research. "Lecture Notes In Computer Science Including Subseries Lecture Notes In Artificial Intelligence And Lecture Notes In Bioinformatics" is the most active journal in terms of publications (N = 169).
    Conclusion: Wayfinding cognition, wayfinding behavior, and individual and group differences are currently the focus of research in the field of healthcare facilities. Future research on wayfinding in healthcare facilities will further investigate intelligent assistive technologies and universal designs such as universal signage systems. In addition, cross-cultural-based wayfinding research is a hot topic for future studies where the boundaries of research are broadened and have practical value.
    Keywords:  Bibliometric analysis; Healthcare facilities; Knowledge structures; VOSviewer; Wayfinding
    DOI:  https://doi.org/10.1016/j.heliyon.2022.e10723
  29. Medicine (Baltimore). 2022 Sep 30. 101(39): e30779
       BACKGROUND: Due to the huge impact of coronavirus disease 2019 (COVID-19) on a global scale, the level of physical activity during confinement has become a widespread concern. This study summarizes the development of performance and research trends in COVID-19 and physical activity over the last 3 years.
    METHODS: Research publications on COVID-19 and physical activity in the past 3 years were downloaded from the Web of Science database. CiteSpace and VOSviewer software were used to analyze the authors, published outputs, journals, cited authors, countries and institutions, co-cited journals, cited references, and keywords. Statistical and centrality analyses were used to identify the active authors, core journals, basic references, hot topics, and cutting-edge fields.
    RESULTS: A total of 1331 papers was retrieved. SMITH L was a prolific author in the field of exercise intervention in COVID-19 with 11 publications. International Journal of Environmental Research and Public Health was the most productive journal (179 publications) and the most cited journal (1324). The most productive countries and institutions in this field were the USA (322 publications) and Harvard Medical School (21 publications). The four hot keywords in COVID-19 and physical activity research were physical activity, exercise, health, and mental health.
    CONCLUSIONS: This study provides researchers with directions to intervene in changing levels of physical activity during the COVID-19 pandemic and valuable information for researchers in the field of sports medicine to identify potential collaborators, collaborating institutions, hot issues, and research frontiers.
    DOI:  https://doi.org/10.1097/MD.0000000000030779
  30. Front Endocrinol (Lausanne). 2022 ;13 997034
       Background: RNA methylation has emerged as an active research field in diabetes mellitus (DM) and its complications, while few bibliometric analyses have been performed. We aimed to visualize the hotspots and trends using bibliometric analysis to provide a comprehensive and objective overview of the current search state in this field.
    Methods: The articles and reviews regarding RNA methylation in DM and its complications were from the Web of Science Core Collection. A retrospective bibliometric analysis and science mapping was performed using the CiteSpace software to plot the knowledge maps and predict the hotspots and trends.
    Results: Three hundred seventy-five qualified records were retrieved. The annual publications gradually increased over the past 20 years. These publications mainly came from 66 countries led by Canada and 423 institutions. Leiter and Sievenpiper were the most productive authors, and Jenkins ranked first in the cited authors. Diabetes Care was the most co-cited journal. The most common keywords were "Type 2 diabetes", "cardiovascular disease", "diabetes mellitus", and "n 6 methyladenosine". The extracted keywords mainly clustered in "beta-cell function", "type 2 diabetes", "diabetic nephropathy", "aging", and "n6-methyladenosine". N6-methyladenosine (m6A) in DM and its complications were the developing areas of study.
    Conclusion: Studies on RNA methylation, especially m6A modification, are the current hotspots and the future trends in type 2 diabetes (T2D) and diabetic nephropathy (DN), as well as a frontier field for other complications of DM. Strengthening future cooperation and exchange between countries and institutions is strongly advisable to promote research developments in this field.
    Keywords:  N6-methyladenosine (m 6 A); RNA methylation; bibliometric analysis; diabetes complications; diabetes mellitus
    DOI:  https://doi.org/10.3389/fendo.2022.997034
  31. New Microbes New Infect. 2022 Jul;48 101020
      
    Keywords:  Africa; analysis; bibliometric; monkeypox; research
    DOI:  https://doi.org/10.1016/j.nmni.2022.101020
  32. Front Cardiovasc Med. 2022 ;9 949859
       Background: Existing studies have indicated that gut microbiota is closely related to the occurrence and development of coronary heart disease(CHD). Gut microbiota and its metabolites may be important diagnostic markers for CHD in the future and are expected to become new targets for the prevention and treatment of CHD. However, the current studies exploring the link between CHD and gut microbiota are miscellaneous and poorly targeted, without bibliometric analysis available.
    Objective: The purpose of this research was to perform a bibliometric and visual analysis of published papers on the relationship between CHD and gut microbiota. The study also sought to identify principal authors, institutions, and countries to analyze the research status and trends of gut microbiota research in the field of CHD.
    Methods: The Web of Science Core Collection (WoSCC) database was searched for publications on CHD and gut microbiota between 2002 and 2022. CiteSpace 5.8. R1, VOSviewer 1.6.16, and Microsoft Excel 2019 software tools were utilized to perform this bibliometric analysis and visualization.
    Results: There were 457 qualified publications found in total, with the annual number of publications increasing. The United States dominated in this field. Hazen, Stanley l was the author of the most papers. Cleveland Clinic published the most papers of any institution. The six main clusters' specific characteristics were discovered through analysis of the co-occurrence of keywords: inflammation, diet, trimethylamine n-oxide, metabolism, cardiovascular disease, and myocardial infarction. Newly emerging research has focused predominantly on gut microbiota metabolites and recent strategies for intervention in coronary atherosclerosis.
    Conclusion: These results provided a useful perspective on current research and future prospects for the research on the link between CHD and gut microbiota, which may help researchers to select suitable collaborators and facilitate their research to elucidate the underlying molecular mechanisms of CHD, including the causes, prevention, and treatment.
    Keywords:  bibliometric analysis; coronary heart disease; gut microbiota; trimethylamine-n-oxide; visual analysis
    DOI:  https://doi.org/10.3389/fcvm.2022.949859
  33. Front Psychol. 2022 ;13 1005487
      Research on COVID-19 has drawn the attention of scholars around the world since the outbreak of the pandemic. Several literature reviews of research topics and themes based on scientometric indicators or bibliometric analyses have already been conducted. However, topics and themes in linguistic-specific research on COVID-19 remain under-studied. With the help of the CiteSpace software, the present study reviewed linguistic research published in SSCI and A&HCI journals to address the identified gap in the literature. The overall performance of the documents was described and document co-citations, keyword co-occurrence, and keyword clusters were visualized via CiteSpace. The main topic areas identified in the reviewed studies ranged from the influences of COVID-19 on language education, and speech-language pathology to crisis communication. The results of the study indicate not only that COVID-19-related linguistic research is topically limited but also that insufficient attention has been accorded by linguistic researchers to Conceptual Metaphor Theory, Critical Discourse Analysis, Pragmatics, and Corpus-based discourse analysis in exploring pandemic discourses and texts.
    Keywords:  COVID-19; CiteSpace; bibliometric analysis; hot topics; linguistics
    DOI:  https://doi.org/10.3389/fpsyg.2022.1005487
  34. Front Cell Neurosci. 2022 ;16 949521
       Background: Stroke, including ischemic stroke and hemorrhagic stroke, possesses complex pathological mechanisms such as neuroinflammation, oxidative stress and blood-brain barrier damage. Astrocyte functions have been reported during injury, neuroprotection and cell crosstalk. It plays a key role in exacerbating stroke injury, promoting neurological repair and enhancing neuroregeneration.
    Aim: This holistic bibliometric analysis aimed to provide a general overview of the recent advancement and the hotspots in the field of stroke and astrocyte from 2001 to 2021.
    Materials and methods: Publications between 2001 and 2021, related to stroke and astrocyte were retrieved from the Web of Science (WOS) and analyzed in Gephi and VOSviewer.
    Results: In total, 3789 documents were extracted from the WOS databases. The publications showed stable growth since 2001. The United States and China were the most prolific countries and University of California San Francisco and Oakland University were the most influential institutes. The top four most productive journals were Brain Research, Journal of Cerebral Blood Flow and Metabolism, Glia and Journal of Neuroinflammation. Keywords frequency and co-occurrence analysis revealed that the topics related to "micro-RNA", "toll like receptor", "neuroinflammation", "autophagy" and "interleukin" were research frontiers. The field of stroke and astrocyte focused on several aspects, such as the role of astrocytes in the treatment of stroke, metabolic changes in astrocytes, the protective role of apoptosis in astrocytes after oxidative stress injury and neurovascular units.
    Conclusion: This comprehensive bibliometric study provides an updated perspective on the trend of research associated with stroke and astrocyte. It will benefit scientific community to identify the important issues, future directions and provide a novel understanding of stroke pathophysiology, hotspots and frontiers to facilitate future research direction.
    Keywords:  astrocytes; bibliometric analysis; citation analysis; scientific outputs; stroke
    DOI:  https://doi.org/10.3389/fncel.2022.949521
  35. Front Med (Lausanne). 2022 ;9 990657
       Purpose: To analyze the development process of small incision lenticule extraction (SMILE) surgery in a 12-year period.
    Methods: We conducted a literature search for SMILE research from 2011 to 2022 using the Science Citation Index Expanded (SCIE) of the Web of Science Core Collection (WoSCC). The VOS viewer, and CiteSpace software were used to perform the bibliometric analysis. Publication language, annual growth trend, countries/regions and institutions, journals, keywords, references, and citation bursts were analyzed.
    Results: A total of 731 publications from 2011 to 2022 were retrieved. Annual publication records grew from two to more than 100 during this period. China had the highest number of publications (n = 326). Sixty-five keywords that appeared more than four times were classified into six clusters: femtosecond laser technology, dry eye, biomechanics, visual quality, complications, and hyperopia.
    Conclusion: The number of literatures has been growing rapidly in the past 12 years. Our study provides a deep insight into publications on SMILE for researchers and clinicians with bibliometric analysis for the first time.
    Keywords:  SMILE; bibliometric analysis; complications; femtosecond laser technology; small incision lenticule extraction
    DOI:  https://doi.org/10.3389/fmed.2022.990657
  36. Front Microbiol. 2022 ;13 1003905
       Background and aim: Ulcerative colitis is a chronic inflammatory bowel disease, and intestinal flora plays an important role in ulcerative colitis. In this study, we conducted a bibliometric analysis of publications in the field of intestinal flora and ulcerative colitis research in the past 10 years to summarize the current status of the field and analyze the trends in the field.
    Methods: On July 15, 2022, we chose the Web of Science Core Collection database as the study's data source. CiteSpace.5.8.R3 and VOSviewer 1.6.17 were used to examine publications of research on intestinal flora and ulcerative colitis that were published between 2012 and 2021. We looked through the papers for journals, organizations, nations and regions, authors, and key terms.
    Results: This analysis covered a total of 2,763 papers on studies into intestinal flora and ulcerative colitis. There were 13,913 authors, 93 nations, 3,069 organizations, and 759 journals in all of the articles. In the USA, 767 publications were the most. The university with the most publications was Harvard Medical School. The author with the most articles was Antonio Gasbarrini.
    Conclusion: This study summarizes the global research trends in intestinal flora and ulcerative colitis. Publications in this field have increased year by year in the last decade and the field of research on intestinal flora and ulcerative colitis has good prospects for growth.
    Keywords:  CiteSpace; VOSviewer; intestinal flora; trends; ulcerative colitis
    DOI:  https://doi.org/10.3389/fmicb.2022.1003905
  37. Environ Sci Pollut Res Int. 2022 Sep 28.
      Rivers are a vital part of the earth's environment and the basis for human survival. River health has been widely concerned by scholars and practitioners, and the number of studies in this area is increasing. In order to examine the evolution of river health research and identify the research frontiers, a total of 675 articles were retrieved from the Web of Science Core Collection database, and CiteSpace was used for bibliometrics. The results revealed that the research on river health is multidisciplinary. Freshwater Biology and Ecological Indicators were two of the most influential journals. Researchers and institutions from America, Australia, and China were the core research forces, and a certain gap was observed between developed and developing countries in river health. The most productive institution was Michigan State University, followed by Griffith University and Hohai University. There are three development trends in river health: (1) Research scale is expanding; (2) Research methods are diversified and interdisciplinary; and (3) Evaluation index is more comprehensive and systematic. The frontier of river health had been expanded from the connotation of river health to the evaluation methods, evaluation indexes, and comprehensive river ecological research. Overall, research on river health is a well-developed and promising research field. This study provides a framework in the river health field for new researchers and helps scholars to identify further potential perspectives on collaborators, research frontiers, hotspots, and research trends.
    Keywords:  Bibliometrics; CiteSpace; Research hotspots; Research trends; River health; River health assessment; Web of Science Core Collection
    DOI:  https://doi.org/10.1007/s11356-022-23267-3
  38. Orthop Rev (Pavia). 2022 ;14(3): 38041
       Background: Total joint replacements are some of the most common procedures performed by surgeons. There has been a recent increase to transition these procedures to the outpatient setting.
    Objective: Our study seeks to identify the most influential publications, in terms of total citations, regarding outpatient total hip and knee replacement surgeries.
    Methods: The database used to collect the data for this analysis was Clarivate Analytics Web of Science. The search query selected and used to collect data was: "outpatient or ambulatory," with a "Title" filter AND "total joint replacement" AND "total joint arthroplast*" with "Topic" filters. The papers returned were then sorted by total number of citations and exported to Google Sheets for further analysis.
    Results: The most cited publication was "Outpatient total knee arthroplasty with a minimally invasive technique," by Berger et al.. This was the oldest publication analyzed (2005), the most recent publication being published in 2020. The publications analyzed were cited a total number of 1,774 times and averaged 35.5 citations per year. The Journal with the most attributable publications was The Journal of Arthroplasty.
    Conclusion: This study provides a measure of the most cited articles on outpatient arthroplasty. Most literature on the topic were categorized as Clinical Science and Outcomes (50%), comprised level of evidence III (28%), were published in the Journal of Arthroplasty (54%) and came out of the United States (76%). Knowledge of these most influential articles allows for a foundation of understanding on a rapidly growing area of arthroplasty among clinicians.
    Keywords:  Total joint arthroplasty; bibliometric review; most influential; outpatient; total hip replacement; total knee replacement
    DOI:  https://doi.org/10.52965/001c.38041
  39. J Oral Pathol Med. 2022 Sep 25.
       BACKGROUD: Cancer-therapy-induced mucosal injury (CMI) is a common and deleterious complication that affects patients undergoing cancer therapies. This study was aimed at elucidating knowledge bases and predicting research trends of this field, by analyzing the bibliographic data of CMI.
    MATERIALS AND METHODS: The bibliographic data of CMI from 2001 to 2021 were extracted from the Web of Science Core Collection database in March 2022. After screening, a total of 8181 articles and reviews were included in the study. CiteSpace and VOSviewer were applied to analyze and visualize cooperation, cooccurrence, cocitation, and coupling networks.
    RESULTS: A steady increase in publications and a burst of citation since 2019 were seen in the subject. Supportive Care in Cancer, International Journal of Radiation Oncology Biology Physics, Annals of Oncology, Cancer, and Radiotherapy and Oncology were the most influential journals of this field. The University of Adelaide, University of Texas MD Anderson Cancer Center, and Memorial Sloan Kettering Cancer Center were the top 3 most productive institutions. ST Sonis, RV Lalla, JB Epstein, and DMK Keefe were the authors with impressive publications and citations. The intellectual base was the publication network of improved treatments based on updating knowledge of CMI. The future trends would be the pathogenesis of CMI, mechanism-based interventions, microbiota of oral and gastrointestinal mucosa, and photobiomodulation.
    CONCLUSION: This study introduced the evolving publication network and predicted the research trends of CMI, which helped researchers to obtain detailed and reliable knowledge of the discipline, and to focus on the most urgent unsolved problems of this field.
    Keywords:  bibliometric analysis; cancer therapy; head and neck cancer; mucosal injury; mucosal toxicity; mucositis; oral mucositis; scientometric analysis
    DOI:  https://doi.org/10.1111/jop.13363
  40. J Stomatol Oral Maxillofac Surg. 2022 Sep 21. pii: S2468-7855(22)00282-8. [Epub ahead of print]
       OBJECTIVES: The aim of this work is to perform a bibliometric analysis on Middle Eastern oral and maxillofacial surgery through years and to compare the data with previous studies. A list of the top 100 most cited articles was generated.
    METHODS: A Pubmed bibliographic search for literature journals specialized in oral and maxillofacial surgery in the Middle East was performed. A graphic representation of authorship and keywords was created with VOSviewer. Mendeley and Microsoft Excel were used for tabulation and data visualization. A list of the top 100 most cited articles was created using Web of Science. Some statistical tests were performed with a 95% confidence interval, which was considered significant.
    RESULTS: A total of 6,536 articles were retrieved in fifteen selected oral and maxillofacial journals. A moderate correlation between number of publications and total population (R = 0.6052), low correlation with area (R = 0.302291), and a negligible correlation with the Human Development Index (HDI) were found (R = 0.1747). A disparity can be seen in the number of publications by country, leaded by Turkey (46.30%), Israel and Iran (13.68% each). The more common studied topic was oral surgery (25.77%), maxillofacial trauma (16.13%) and oral pathology (10.25%).
    CONCLUSIONS: A useful list of the top 100 most cited articles on oral and maxillofacial surgery from Middle East has been created. Middle East publications on oral and maxillofacial surgery can be considered high quality (IF = 1.879). Some issues on performing an adequate selecting of MeSH keywords were discussed.
    Keywords:  Ameloblastoma; Bibliometrics; Cleft Lip; Iran; Maxillofacial Injuries; Middle East; Orthognathic Surgery; Pathology, Oral; Surgery, Oral; Syria; Turkey; Yemen
    DOI:  https://doi.org/10.1016/j.jormas.2022.09.014
  41. Front Pharmacol. 2022 ;13 956204
      Irritable bowel syndrome (IBS) is a gastrointestinal disorder with no structural damage, and its pathogenesis remains unclear. Studies have shown that the brain-gut axis is closely related to the occurrence of IBS. However, studies of IBS related to the brain-gut axis have not been systematically analyzed by bibliometrics and visual analysis. This study is based on 631 publications in the Web of Science Core Collection (WoSCC) to analyze hot spots and trends in this field. The collaborations between different authors, institutions, countries, and keywords were bibliometrically analyzed by CiteSpace software. Meanwhile, VOSviewer analyzed the references. The results show that since 2012, the number of publications has been growing rapidly. According to the collaborative network analysis, the United States, the National University of Ireland, Cork, and J.F. Cryan are the countries, institutions, and authors contributing the most, respectively. Through keywords and literature analysis, mechanisms and therapy associated with IBS and the brain-gut axis have still been a research focus in recent years. Furthermore, the physiological and pathological mechanisms of the brain-gut axis influencing IBS (related to gastrointestinal dysfunction, vagus nerve, visceral pain, intestinal flora, serotonin, tryptophan metabolism, stress, brain-derived neurotrophic factor (BDNF), and malonyldialdehyde) are the future research trends, especially the mechanisms related to intestinal flora. This is the first bibliometric and visualization analysis of IBS and brain-gut axis-related literature to explore research hotspots and trends.
    Keywords:  bibliometrics; brain–gut axis; irritable bowel syndrome; microbiome; visualization analysis
    DOI:  https://doi.org/10.3389/fphar.2022.956204
  42. Orthop Rev (Pavia). 2022 ;14(3): 38435
       Background: Clinical Orthopaedics and Related Research is one of the most influential and reputable scientific journals in the field of orthopaedics. Some of the most reputable publications related to orthopaedic research can be attributed to this journal and it continues to have a significant impact on modern research.
    Objective: The purpose of this study is to identify the most influential articles, in terms of number of citations, published by Clinical Orthopaedics and Related Research. The goal of analyzing the most cited articles in is to create a baseline for future researchers to build upon and to uncover any trends in orthopaedic research.
    Methods: Preferred Reporting Items for Systematic Reviews guidelines were used to structure the data collection and analysis of this study. The Scopus database was used to compile the publication data. Data was then exported to an excel sheet to be further analyzed via a multi-author review process.
    Results: The most cited article was "A Clinical Method of Functional Assessment of the Shoulder" by Constant et al.. The 50 articles analyzed in this study were cited a total of 32,404 times, averaging 719 citations per year, per publication. The oldest article was published in 1971, and the newest in 2008. The United States was the country with the most attributable publications and The University of Florida was the most contributory institution.
    Conclusions: Our study recognizes Clinical Orthopaedics and Related research as having a strong predilection for older articles and a continued strength for modern publications.
    Keywords:  CORR; Most Cited Publications; Orthopaedics
    DOI:  https://doi.org/10.52965/001c.38435
  43. Front Psychol. 2022 ;13 972515
       Purpose: This study aimed to explore current developments and trends in the field of subjective well-being (SWB) of older adults at a macro level and identify research hotspots.
    Methods: We included reviews and articles on the SWB of older adults in the Web of Science Core Collection published from 2002 to 2021. We used CiteSpace to draw a knowledge map of the authors, institutions, countries, references, and keywords for visual analysis and used Microsoft Excel tables to count basic information details.
    Results: A total of 354 papers were included, and the number of papers published over the past two decades showed a pattern of growth. The core force of publications was primarily attributed to studies conducted in Europe, North America, Asia, and Oceania, which have relatively major issues of aging and good economic strength. However, links between states, institutions, and authors were relatively weak. Cluster analysis showed that the research field could be divided into eight topics: the application of social psychology in the study of the SWB of older adults, aging in older adults, health condition of older adults, achieving successful aging, interventions for SWB, age differences in SWB research, an economic perspective of SWB research and social support for older adults. Current research frontiers are socioeconomic status, community, intervention, participation, adjustment, validation, and personality.
    Conclusion: The results of the present study provided a comprehensive picture in the research field of SWB of older adults. It showed that the mechanism, especially the bidirectional effect, between the SWB of older adults and its influencing factors is still worthy of further exploration. More research on evidence-based and intervention strategies should be conducted in the future.
    Keywords:  CiteSpace; bibliometric analysis; older adults; research trends; subjective well-being
    DOI:  https://doi.org/10.3389/fpsyg.2022.972515
  44. ESMO Open. 2022 Sep 26. pii: S2059-7029(22)00220-4. [Epub ahead of print]7(5): 100590
       BACKGROUND: There has historically been women underrepresentation on editorial boards of peer-reviewed medical journals. High-ranked oncology journals showcase cancer-related scientific work at the forefront of the discipline. There is urgent need to investigate gender representation on editorial boards at leading oncology journals.
    MATERIALS AND METHODS: Sixty high-ranked oncology journals based on impact factor calculated by the Journal Citation Reports (JCR) 2021 from Web of Science/Clarivate Analytics were identified. Gender-related information of editorial boards was obtained from each journal's website. The gender of each member of the editorial team was confirmed by an internet search for picture and/or gender-specific pronoun from journal or personal profile. Fisher's exact tests and analysis of variance were used to analyze categorical and continuous variables, respectively. Significance was set at P < 0.05.
    RESULTS: Among 4898 members on editorial boards of top oncology journals with the highest impact factor, 1177 were women. Women made up 24% (1177 of 4898) of members on editorial boards in top oncology journals, and there was significantly less women board members than men (P < 0.0001). The mean female composition of editorial boards of oncology journals was 27% (range from 4% to 100%). Among 71 editors-in-chief of the top oncology journals, 14 (20%) were women. There was a positive correlation between the presence of women in journal editorial leadership and the percentage of women on editorial boards (rs = 0.340, P = 0.008). The underrepresentation of women on oncology journal editorial boards was significantly different among quartiles of journal impact factor. There was no significant correlation between women's representation on journal editorial boards (%) and journal impact factors (rs = 0.226, P = 0.086).
    CONCLUSIONS: The results demonstrated that there are gender disparities among editorial leadership at high-impact oncology journals. There are cultural and structural barriers and prejudices to gender parity and diversity on editorial boards of oncology journals.
    Keywords:  editorial board; gender bias; gender parity; oncology journal; women’s representation
    DOI:  https://doi.org/10.1016/j.esmoop.2022.100590
  45. Medicine (Baltimore). 2022 Sep 30. 101(39): e30317
       BACKGROUND: Thermoreceptors include TRPV1 and TRPM8. TRPV1 and TRPM8 are TRP channels. TRP ion channels are widely expressed in many different tissues and cell types, and are involved in different physiological processes. Research on the structure and basic physiological functions of TRPV1 is relatively perfect, and the relationship between the pathogenesis of other members of the TRP family and specific diseases and TRPV1 remains to be explored in depth.
    METHODS: Articles regarding TRP were culled from the Web of Science Core Collection, and knowledge maps were generated using the CiteSpace software.
    RESULTS: In total, 19,862 articles were included. The number of published articles on this topic has rapidly increased since 2000, with more than 1000 articles published per year by 2020. MAKOTO TOMINAGA was the author with the most articles. The countries with the most articles were the United States and China. However, the number of articles in the U.S. was 3 times that in China. The organizations that publish the most articles are Harvard University in the US and Seoul Natl University in South Korea. TRP and the pathogenesis of diseases, such as neuropathy and stroke, are hotspots of current research.
    CONCLUSION: To our knowledge, this is the first study to provide an overview of the literature on TRP. Research on TRPs is developing rapidly.
    DOI:  https://doi.org/10.1097/MD.0000000000030317
  46. IEEE Trans Vis Comput Graph. 2022 Sep 26. PP
      The IEEE VIS Conference (VIS) recently rebranded itself as a unified conference and officially positioned itself within the discipline of Data Science. Driven by this movement, we investigated (1) who contributed to VIS, and (2) where VIS stands in the scientific world. We examined the authors and fields of study of 3,240 VIS publications in the past 32 years based on data collected from OpenAlex and IEEE Xplore, among other sources. We also examined the citation flows from referenced papers (i.e., those referenced in VIS) to VIS, and from VIS to citing papers (i.e., those citing VIS). We found that VIS has been becoming increasingly popular and collaborative. The number of publications, of unique authors, and of participating countries have been steadily growing. Both cross-country collaborations, and collaborations between educational and non-educational affiliations, namely "cross-type collaborations", are increasing. The dominance of the US is decreasing, and authors from China are now an important part of VIS. In terms of author affiliation types, VIS is increasingly dominated by authors from universities. We found that the topics, inspirations, and influences of VIS research is limited such that (1) VIS, and their referenced and citing papers largely fall into the Computer Science domain, and (2) citations flow mostly between the same set of subfields within Computer Science. Our citation analyses showed that award-winning VIS papers had higher citations. Interactive visualizations, replication data, source code and supplementary material are available at https://32vis.hongtaoh.com and https://osf.io/zkvjm.
    DOI:  https://doi.org/10.1109/TVCG.2022.3209422
  47. Front Public Health. 2022 ;10 933665
       Background: Artificial intelligence (AI) has become widely used in a variety of fields, including disease prediction, environmental monitoring, and pollutant prediction. In recent years, there has also been an increase in the volume of research into the application of AI to air pollution. This study aims to explore the latest trends in the application of AI in the field of air pollution.
    Methods: All literature on the application of AI to air pollution was searched from the Web of Science database. CiteSpace 5.8.R1 was used to analyze countries/regions, institutions, authors, keywords and references cited, and to reveal hot spots and frontiers of AI in atmospheric pollution.
    Results: Beginning in 1994, publications on AI in air pollution have increased in number, with a surge in research since 2017. The leading country and institution were China (N = 524) and the Chinese Academy of Sciences (N = 58), followed by the United States (N = 455) and Tsinghua University (N = 33), respectively. In addition, the United States (0.24) and the England (0.27) showed a high degree of centrality. Most of the identified articles were published in journals related to environmental science; the most cited journal was Atmospheric Environment, which reached nearly 1,000 citations. There were few collaborations among authors, institutions and countries. The hot topics were machine learning, air pollution and deep learning. The majority of the researchers concentrated on air pollutant concentration prediction, particularly the combined use of AI and environmental science methods, low-cost air quality sensors, indoor air quality, and thermal comfort.
    Conclusion: Researches in the field of AI and air pollution are expanding rapidly in recent years. The majority of scholars are from China and the United States, and the Chinese Academy of Sciences is the dominant research institution. The United States and the England contribute greatly to the development of the cooperation network. Cooperation among research institutions appears to be suboptimal, and strengthening cooperation could greatly benefit this field of research. The prediction of air pollutant concentrations, particularly PM2.5, low-cost air quality sensors, and thermal comfort are the current research hotspot.
    Keywords:  CiteSpace; air pollution; artificial intelligence; bibliometric analysis (BA); public health
    DOI:  https://doi.org/10.3389/fpubh.2022.933665
  48. World J Clin Cases. 2022 Aug 26. 10(24): 8432-8435
      Analysis of the articles published in any journal is necessary to ascertain the performance of the journal in the academia. The author made a scientometric analysis of the articles published in the World Journal of Clinical Cases in the past 5 years and present the data to the readers.
    Keywords:  Keywords; Research publication; Scientific journal; Scientometrics; Trend analysis; World Journal of Clinical Cases
    DOI:  https://doi.org/10.12998/wjcc.v10.i24.8432
  49. World J Gastroenterol. 2022 Jul 28. 28(28): 3720-3731
       BACKGROUND: Clostridioides (Clostridium) difficile (C. difficile) is still the most common cause of healthcare-associated diarrhoea and is increasing in prevalence as a community-acquired infection. In addition, the emergence of antibiotic resistance in C. difficile can increase the likelihood of the disease developing and/or spreading.
    AIM: To provide an up-to-date picture of the trends in publications related to C. difficile infection, together with specific insights into hot-button issues in this field.
    METHODS: Publications on C. difficile infections in the field of microbiology between 2001 and 2020 were identified from the Scopus database and Reference Citation Analysis. Bibliometric indicators were determined, including the number and type of publications, countries, affiliations, funding agencies, journals and citation patterns. VOSviewer was used to determine research areas and hot-button issues by identifying recurring terms with a high relative occurrence in the title and abstract.
    RESULTS: A total of 8127 documents on 'C. difficile-associated diarrhoea' published between 2001 and 2020 were retrieved from the Scopus database. In the last decade, there has been a significant almost fourfold increase in the number of published papers on this topic. The United States was among the countries (44.11%) with the most publications, and the most involved institution was the University of Leeds in the United Kingdom (2.50%). Three clusters of research were identified and included 'illness spectrum and severity, as well as the signs, symptoms and clinical pathogenesis of C. difficile'; 'laboratory diagnosis and characterization of C. difficile' and 'risk factors for C. difficile infection'.
    CONCLUSION: This study contains the most up-to-date and comprehensive data ever compiled in this field. More international research and cross-institutional collaborations are needed to address more global C. difficile concerns and to benefit from greater sharing of expertise, which will result in higher quality or more effective studies in the future. Promising research avenues in the near future may draw the attention of relevant scientists and funding organizations and open up novel C. difficile infection-based diagnosis and treatment approaches.
    Keywords:   Clostridium difficile; Bibliometric; Clostridioides; Diarrhoea; Scopus; VOSviewer
    DOI:  https://doi.org/10.3748/wjg.v28.i28.3720
  50. Dig Liver Dis. 2022 Sep 24. pii: S1590-8658(22)00693-4. [Epub ahead of print]
      
    Keywords:  Bibliometric analysis; Management; Pancreatic cystic neoplasms; Review; Web of science
    DOI:  https://doi.org/10.1016/j.dld.2022.09.002
  51. Environ Sci Pollut Res Int. 2022 Sep 28.
      The concept of carbon neutrality has been promoted and implemented in increasing countries since the twenty-first century. In-depth research on carbon neutrality has helped improve the environmental conditions and played a particular role in sustaining economic and social development. However, there is a less comprehensive review of the status in this field; therefore, this article uses the information visualization software CiteSpace to thoroughly analyze carbon neutrality research from multiple perspectives. This study aims to reveal the current research evolutions and hotspots in this field, predict future research trends, and construct the framework for better understanding. The results find that the number of papers published on carbon neutrality keeps increasing annually, and carbon neutrality has been the widely participated domain. In addition, publications by organizations and in top journals have aroused wide attention, and the hot spots on carbon neutrality have shifted to policy, recovery, and efficiency. Based on the results, a knowledge framework of this domain is constructed to give readers a clearer understanding of the evolvement and trends, which will also provide targeted references and help for future researchers.
    Keywords:  Analysis; Bibliometric; Carbon neutrality; CiteSpace; Framework; Visualization
    DOI:  https://doi.org/10.1007/s11356-022-23283-3
  52. Front Bioeng Biotechnol. 2022 ;10 998257
      Osteogenesis serves an important role in bone tissue repairing. Novel biomaterials are widely prevalent as materials for orthopedic implants due to their biocompatibility and osteogenetic ability. The purpose of this study was to comprehensively analyze hotspots and future trend of biomaterials research in osteogenesis based on bibliometric and visualized analysis. A total of 1,523 papers about biomaterials research in osteogenesis between 2000 and 2021 were included in this study. During the above 20 years, China's leading position in the global biomaterials research in osteogenesis was obvious, and it was also the country that most frequently participates in international cooperation. Chinese Academy of Sciences was the most productive institution and the leader of research cooperation. Acta Biomaterialia and Biomaterials have published the largest number of articles in the field of biomaterials research in osteogenesis. Meanwhile, Acta Biomaterialia and Biomaterials were also the two journals with the highest total citation frequency. Wu CT, Chang J, Kaplan DL, and Xiao Y all made important contributions in the field of biomaterials research in osteogenesis. At present, there are five research hotspots in the field of biomaterials research in osteogenesis: 1) the immunomodulatory role of biomaterial-related inflammatory; 2) mechanisms of osteogenesis in biomaterials; 3) 3D printing and clinical application of biomaterials; 4) bone tissue engineering for biomaterial osteogenesis; and 5) regenerative medicine for biomaterial osteogenesis. The results of this study showed that mechanisms of osteogenesis in biomaterials, bone tissue engineering for biomaterial osteogenesis, and regenerative medicine for biomaterial osteogenesis will remain research hotspots in the future. International cooperation was also expected to expand and deepen the field of biomaterials research in osteogenesis.
    Keywords:  bibliometric analysis; biomaterials; orthopedic implants; osseointegration; osteogenesis
    DOI:  https://doi.org/10.3389/fbioe.2022.998257
  53. Int Wound J. 2022 Sep 26.
      Diabetic foot (DF) has become a serious health problem in modern society, and it has been a hotspot of research for a long time. However, little scientometric analysis has been carried out on DF. In the present study, we analysed 8633 literature reports on DF in the Web of Science Core Collection from database inception until April 23, 2022. VOSviewer (Centre for Science and Technology Studies at Leiden University, Leiden, the Netherlands) and CiteSpace (College of Computing and Informatics, Drexel University, Philadelphia, United States) were employed to address high-impact countries and institutions, journals, references, research hotspots, and key research fields in DF research. Our analysis findings indicated that publications on DF have increased markedly since 2016 and were primarily published in the United States of America. The recent studies focus on the amniotic membrane, foot ulcers, osteomyelitis, and diabetic wound healing. The five keyword clusters, which included DF ulcer and wound healing therapies, management and guidelines, neuropathy and plantar pressure, amputation and ischemia, and DF infection and osteomyelitis, are helpful for enhancing prevention, standardising treatment, avoiding complications, and improving prognosis. These findings indicated a method for future therapies and research in DF.
    Keywords:  CiteSpace; VOSviewer; diabetic foot; scientometrics analysis; visualisation
    DOI:  https://doi.org/10.1111/iwj.13964
  54. PLoS One. 2022 ;17(9): e0275192
      The rapid development of modern science nowadays makes it rather challenging to pick out valuable ideas from massive scientific literature. Existing widely-adopted citation-based metrics are not adequate for measuring how well the idea presented by a single publication is developed and whether it is worth following. Here, inspired by traditional X-ray imaging, which returns internal structure imaging of real objects along with corresponding structure analysis, we propose Scientific X-ray, a framework that quantifies the development degree and development potential for any scientific idea through an assembly of 'X-ray' scanning, visualization and parsing operated on the citation network associated with a target publication. We pick all 71,431 scientific articles of citation counts over 1,000 as high-impact target publications among totally 204,664,199 publications that cover 16 disciplines spanning from 1800 to 2021. Our proposed Scientific X-ray reproduces how an idea evolves from the very original target publication all the way to the up to date status via an extracted 'idea tree' that attempts to preserve the most representative idea flow structure underneath each citation network. Interestingly, we observe that while the citation counts of publications may increase unlimitedly, the maximum valid idea inheritance of those target publications, i.e., the valid depth of the idea tree, cannot exceed a limit of six hops, and the idea evolution structure of any arbitrary publication unexceptionally falls into six fixed patterns. Combined with a development potential index that we further design based on the extracted idea tree, Scientific X-ray can vividly tell how further a given idea presented by a given publication can still go from any well-established starting point. Scientific X-ray successfully identifies 40 out of 49 topics of Nobel prize as high-potential topics by their prize-winning papers in an average of nine years before the prizes are released. Various trials on articles of diverse topics also confirm the power of Scientific X-ray in digging out influential/promising ideas. Scientific X-ray is user-friendly to researchers with any level of expertise, thus providing important basis for grasping research trends, helping scientific policy-making and even promoting social development.
    DOI:  https://doi.org/10.1371/journal.pone.0275192
  55. Eur J Paediatr Dent. 2022 Sep;23(3): 173
      Bibliometrics is the statistical analysis of scientific publications and trends on a given topic. The use of bibliometric indicators is based on the fact that academic publishing is an essential outcome of research activity, as advancement of science and treatments increases with dissemination of knowledge. Therefore, investigation in our specific field is obligatory, as learning what the current lines of research are can help us to properly orient our research in the coming years. A soon-to-be-published paper analyses 3,027 articles that have appeared in the leading journals of Paediatric Dentistry included in the Journal Citation Reports (JCR): Pediatric Dentistry, the International Journal of Pediatric Dentistry, the European Journal of Paediatric Dentistry and the Journal of Clinical Pediatric Dentistry considering all issues and all articles published from 2008 to 2020. The most frequently addressed topic is surgery (23.4%), which more generally includes pulp treatment, conservative treatments and the use of dental materials (operative dentistry), while the second most discussed topic is prevention (13.2%), followed by oral pathology (10.6%). Subject matters covered less frequently include early childhood caries (ECC) (2.5%) and occlusion (2.7%). In terms of study types, research articles are the most frequently published (74.2%). Among them, the most common study design is observational studies (61.1%), followed by cross-sectional studies (36.9%) and case-control studies (11.9%). With regard to experimental studies, randomised controlled trials (RCTs) are the most common type (11.6%). The number of case series has fallen sharply over time, from 20% 10 years ago to 5% today. Another striking point is that two journals, the International Journal of Pediatric Dentistry and the European Journal of Paediatric Dentistry, have published more than half of the world's output. By looking at the nationality of the authors, it is apparent that research frequently takes place within limited geographical areas, a sign that collaboration between different countries is struggling to take off. Despite the fact that prevention is the second most common topic among the articles analysed in the study-both in absolute terms and also taking into account dental journals focused on different specialties-it still does not play the prominent role it deserves. It is important to emphasise the need for further investigation into the prevention of dental diseases in young patients, as the desired oral health objectives have not yet been achieved. The early identification of risk indicators and the implementation of preventive oral health campaigns aimed at the paediatric population can reduce or prevent the progression of caries, and related expenditures for the replacement of missing teeth at a later age. A final consideration is how interesting it would be to analyse how many of the paediatric medical journals publish papers and articles on paediatric dentistry, as this is in fact another crucial step towards ensuring good oral health for all our young patients!
    DOI:  https://doi.org/10.23804/ejpd.2022.23.03.01
  56. J Environ Manage. 2022 Sep 27. pii: S0301-4797(22)01838-2. [Epub ahead of print]324 116265
      Impact of heavy metal (HM) pollution and its understanding on environment as well as human beings has grown a lot during the last few decades. The goal of this study is to create a scientometric study on heavy metal contamination, in the period 1989 to 2020, in order to provide futuristic goals for the new researchers on wastewater treatment. For this, a search was conducted in the Web of Science (WoS) and Scopus databases, related to heavy metal pollution. Totally, 37,154 records were collected during the study period from 1989 to 2020. The findings revealed that China, the United States, and India has most referenced papers across a wide range of trans disciplinary issues such as toxicity, technology, and pollution. As a result, this study concludes that more research on various treatment methods is required in order to obtain high-quality water for consumption and routine activities, with the incorporation of various treatment tasks poses various challenges for the upcoming future studies.
    Keywords:  Bibliometric analysis; Health risk; Heavy metal pollution; Histcite; VosViewer; Wastewater treatment
    DOI:  https://doi.org/10.1016/j.jenvman.2022.116265
  57. J Hist Behav Sci. 2022 Sep 30.
      This paper presents a brief history of Yugoslav psychology and a review of the current state of psychological research and practice in the former Yugoslav countries. Bibliometric mapping was used to explore the knowledge domain and international visibility of psychological research in Bosnia and Herzegovina, Croatia, North Macedonia, Montenegro, Serbia, and Slovenia. Judging by the number of papers visible in Scopus, psychological research activity in these countries is similar to the other former communist countries. In a relative sense, it is even higher in Slovenia and Croatia. However, psychologists still rely heavily on national journals indexed in Scopus when publishing their papers. Regarding psychological practice, former Yugoslav countries are facing challenges that are more or less typical for all small countries in the global scientific and economic market. Keeping in mind all the obstacles and traumas in the past decades, it should be considered a success that psychology in the former Yugoslav countries is now a fully established profession and a recognized scientific discipline.
    Keywords:  bibliometric analysis; former Yugoslavia; national journals; psychological practice; psychological research
    DOI:  https://doi.org/10.1002/jhbs.22232
  58. World Neurosurg. 2022 Sep 23. pii: S1878-8750(22)01362-6. [Epub ahead of print]
       BACKGROUND: Given the neurotrauma that soldiers might face during wars, a byproduct of such devastating neurosurgical conditions can be novel data, which can act as a catalyst for potentially paradigm-shifting research. We aimed to identify the impact of major US military campaigns on military neurosurgery literature across defined time periods.
    METHODS: A comprehensive Elsevier's Scopus database search was performed to capture all published and indexed studies from 1915 to 2021 relevant to military neurosurgery. A discrete set of validated informetric metadata parameters were extracted and analyzed using productivity analysis, citation analysis, keyword analysis, text mining, content analysis, and collaboration network mapping.
    RESULTS: Our search yielded 2,216 documents. Annual scientific production since 1915 grew at a compounded rate of 6.1% per year, with the most significant increases during US military campaigns (coefficient=42.9, p<0.001) and following the introduction of the Department of Defense (DoD) Trauma Registry in 2007 (coefficient=114.5; p<0.001). Each war had a direct influence on military neurosurgery literature growth (p<0.05), with the most prominent following the Afghanistan war. The journals with the most publications on military neurosurgery were Military Medicine (n=168) and Journal of Head Trauma. The topmost cited author was Hoge et al. (N=2,083), while the topmost cited country was the United States (N=1,098).
    CONCLUSION: Since World War II, the military has contributed significant historical developments to neurosurgery, the most prominent being after the Iraq and Afghanistan wars and the introduction of the DoD Trauma Registry.
    Keywords:  combat; impact; informetric; military; neurosurgery; spine; war
    DOI:  https://doi.org/10.1016/j.wneu.2022.09.085
  59. R Soc Open Sci. 2022 Sep;9(9): 220440
      Many publications on COVID-19 were released on preprint servers such as medRxiv and bioRxiv. It is unknown how reliable these preprints are, and which ones will eventually be published in scientific journals. In this study, we use crowdsourced human forecasts to predict publication outcomes and future citation counts for a sample of 400 preprints with high Altmetric score. Most of these preprints were published within 1 year of upload on a preprint server (70%), with a considerable fraction (45%) appearing in a high-impact journal with a journal impact factor of at least 10. On average, the preprints received 162 citations within the first year. We found that forecasters can predict if preprints will be published after 1 year and if the publishing journal has high impact. Forecasts are also informative with respect to Google Scholar citations within 1 year of upload on a preprint server. For both types of assessment, we found statistically significant positive correlations between forecasts and observed outcomes. While the forecasts can help to provide a preliminary assessment of preprints at a faster pace than traditional peer-review, it remains to be investigated if such an assessment is suited to identify methodological problems in preprints.
    Keywords:  forecasting; preprinting; science policy
    DOI:  https://doi.org/10.1098/rsos.220440
  60. Proc Natl Acad Sci U S A. 2022 Oct 04. 119(40): e2206070119
      Diversity in science is necessary to improve innovation and increase the capacity of the scientific workforce. Despite decades-long efforts to increase gender diversity, however, women remain a small minority in many fields, especially in senior positions. The dearth of elite women scientists, in turn, leaves fewer women to serve as mentors and role models for young women scientists. To shed light on gender disparities in science, we study prominent scholars who were elected to the National Academy of Sciences. We construct author citation networks that capture the structure of recognition among scholars' peers. We identify gender disparities in the patterns of peer citations and show that these differences are strong enough to accurately predict the scholar's gender. In contrast, we do not observe disparities due to prestige, with few significant differences in the structure of citations of scholars affiliated with high-ranked and low-ranked institutions. These results provide further evidence that a scholar's gender plays a role in the mechanisms of success in science.
    Keywords:  bibliometrics; gender; gender disparities; science of science
    DOI:  https://doi.org/10.1073/pnas.2206070119
  61. Front Genet. 2022 ;13 979761
      The Frontiers Media family has over 200 journals, which are each headed by usually one Field Chief Editor, and several thousand specialty sections, which are each headed by one or more Specialty Chief Editors. The year 2021 was the 10th anniversary of the founding of the Frontiers in Genetics journal and the Frontiers in Toxicogenomics specialty section of this journal. In 2021, we also announce one of the newest of the Frontiers journals-Frontiers in Toxicology which is part of the Frontiers Media family of journals but independent of Frontiers in Genetics. Dr. Ruden is the founding, and currently sole, Specialty Chief Editor of Frontiers in Toxicogenomics and one of 9 Specialty Chief Editors of Frontiers in Toxicology. The new Field Chief editor of Frontiers in Toxicology will be Dr. Bengt Fadeel of the Karolinska Institute in Sweden. As of 2021, Frontiers in Toxicogenomics has published over 138 articles and has over 370 Editors including 90 Associate Editors and 280 Review Editors. The Frontiers in Genetics impact factor was initially approximately 2.5 when it was first listed in PubMed in 2015 and has risen steadily to its current value of 4.8, which is typical for the majority of the over 200 Frontiers journals that have established impact factors. In this overview of the first decade of Frontiers in Toxicogenomics, we discuss the top 5 articles with the highest Scopus citations, which were all written in the first few years of the journal. The article with the highest number of citations, with 353 Scopus over 600 Google Scholar citations, and the highest average number of citations (67) that steadily increased from 10 citations in 2013 to 119 citations in 2021, was written in 2012 by Dr. Ruden's laboratory and titled, "Using Drosophila melanogaster as a model for genotoxic chemical mutational studies with a new program, SnpSift." The five most influential authors who published in the journal in the past 10 years based on Scopus citations of a particular paper are Dr. Ruden's laboratory, with 353 Scopus citations for the SnpSift paper mentioned above; Drs. Brock Christensen and Carmen J. Marsit, with 86 Scopus citations for their review, "Epigenomics in environmental health"; Dr. Michael Aschner and colleagues, with 61 Scopus citations for their paper "Genetic factors and manganese-induced neurotoxicity"; and Dr. Sandra C. dos Santos and colleagues, with 59 Scopus citations for their paper, "Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnology." While the top 5 papers were published in the early years of the journal, we will also discuss a more recent article published in 2018 on a comparison of RNA-seq and microarray methods by Dr. Michael Liguori's laboratory, "Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies," that far exceeds the number of downloads and views of all the other articles published in the first 10 years of the journal and will likely be a top cited paper in the second decade highlights of this journal. Finally, we discuss where the Frontiers in Toxicogenomics specialty journal and the Frontiers in Toxicology journal will go to advance the field of toxicogenomics, and more generally, toxicology, in the future.
    Keywords:  environmental health; epigenomics; genomics; toxicogenomics; toxicology; transcriptomics
    DOI:  https://doi.org/10.3389/fgene.2022.979761
  62. Parasit Vectors. 2022 Sep 29. 15(1): 346
       BACKGROUND: Mosquito-borne diseases (e.g., transmitted by Aedes aegypti) affect almost 700 million people each year and result in the deaths of more than 1 million people annually.
    METHODS: We examined research undertaken during the period 1951-2020 on the effects of temperature and climate change on Ae. aegypti, and also considered research location and between-country collaborations.
    RESULTS: The frequency of publications on the effects of climate change on Ae. aegypti increased over the period examined, and this topic received more attention than the effects of temperature alone on this species. The USA, UK, Australia, Brazil, and Argentina were the dominant research hubs, while other countries fell behind with respect to number of scientific publications and/or collaborations. The occurrence of Ae. aegypti and number of related dengue cases in the latter are very high, and climate change scenarios predict changes in the range expansion and/or occurrence of this species in these countries.
    CONCLUSIONS: We conclude that some of the countries at risk of expanding Ae. aegypti populations have poor research networks that need to be strengthened. A number of mechanisms can be considered for the improvement of international collaboration, representativity and diversity, such as research networks, internationalization programs, and programs that enhance representativity. These types of collaboration are considered important to expand the relevant knowledge of these countries and for the development of management strategies in response to climate change scenarios.
    Keywords:  Bibliometric analysis; International collaboration; Primary dengue virus vector; Temperature effects
    DOI:  https://doi.org/10.1186/s13071-022-05473-7
  63. BMC Biol. 2022 Sep 30. 20(1): 211
       BACKGROUND: While specialization plays an essential role in how scientific research is pursued, we understand little about its effects on a researcher's impact and career. In particular, the extent to which one specializes within their chosen fields likely has complex relationships with productivity, career stage, and eventual impact. Here, we develop a novel and fine-grained approach for measuring a researcher's level of specialization at each point in their career and apply it to the publication data of almost 30,000 established biomedical researchers to measure the effect that specialization has on the impact of a researcher's publications.
    RESULTS: Using a within-researcher, panel-based econometric framework, we arrive at several important results. First, there are significant scientific rewards for specialization-25% more citations per standard deviation increase in specialization. Second, these benefits are much higher early in a researcher's career-as large as 75% per standard deviation increase in specialization. Third, rewards are higher for researchers who publish few papers relative to their peers. Finally, we find that, all else equal, researchers who make large changes in their research direction see generally increased impact.
    CONCLUSIONS: The extent to which one specializes, particularly at the early stages of a biomedical research career, appears to play a significant role in determining the citation-based impact of their publications. When this measure of impact is, implicitly or explicitly, an input into decision-making processes within the scientific system (for example, for job opportunities, promotions, or invited talks), these findings lead to some important implications for the system-level organization of scientific research and the incentives that exist therein. We propose several mechanisms within modern scientific systems that likely lead to the scientific rewards we observe and discuss them within the broader context of reward structures in biomedicine and science more generally.
    Keywords:  Bibliometrics; Research systems; Science of science; Scientific careers; Scientific impact; Scientific specialization
    DOI:  https://doi.org/10.1186/s12915-022-01400-5
  64. J Anaesthesiol Clin Pharmacol. 2022 Apr-Jun;38(2):38(2): 240-244
       Backgroud and Aims: Conference presentations provide an opportunity to rapidly share findings of new research despite limitations of details and reach. Earlier studies have examined publication rates of conference presentations in anesthesia. However, conversion rate of neuroanesthesia meeting presentations to publications is unknown. We assessed the publication rate of neuroanesthesia conference presentations from India over a 5-year period and identified factors contributing to subsequent publications.
    Material and Methods: Conference abstracts of the Indian Society of Neuroanaesthesiology and Critical Care (ISNACC) from 2014 to 2018 were studied with regard to conversion to full-length publications. Details of presentations were obtained from abstracts published in the journal of ISNACC and details of publications were collected by searching Google and PubMed using title and author details.
    Results: Only 17.5% (40/229) of the abstracts presented at ISNACC conferences over a 5-year period resulted in subsequent full-text publications in peer-reviewed journals. Prospective cohort studies (OR [95% CI] 2.84 [1.05-8.56], P = 0.048), randomized trials (OR [95% CI] 2.69 [1.04 to 7.9], P = 0.053), and abstracts from public institutions (OR [95% CI] 3.44 [1.4 to 10.42], P = 0.014) were significantly associated with publications after conference presentations.
    Conclusion: The conversion rate of conference presentations of neuroanesthesia society of India into journal publications is significantly low. There is need for neuroanesthesia community of India to work together to improve the translation of presentations into publications.
    Keywords:  Audit; India; meetings; neuroanesthesia; presentations; publications
    DOI:  https://doi.org/10.4103/joacp.JOACP_4_21
  65. Front Public Health. 2022 ;10 1009203
      A variety of studies have been conducted in Occupational diseases (ODs) and this makes it difficult for researchers to identify new areas of study. Therefore, the present study was conducted by examining Web of Science data to identify hot topics and research topics on ODs. This is a scientometric study performed using CiteSpace and Gephi software for statistical analysis. The published article in Web of Sciences was searched using the keywords "Occupational disease*" OR "Occupational illness*" OR "Industrial disease*" OR "Industrial illness*". Finally, the countries and institutions and their cooperation, the most important and main topics discussed, and the path of future progress in ODs was analyzed. Preliminary results of the study show that out of 5,947 articles. The results of important journals showed that the American Journal of Industrial Medicine with 233 articles (6.02%), Oxford Occupational Medicine, and International Archives of Occupational and Environmental Health with 86 (2.22%), and 83 (2.15%), respectively. The two producing countries are the United States and Germany, which published 628 and 419 articles, respectively. The results of hot topics showed occupational exposures, epidemiology, mental health, and respiratory diseases were the most important keywords used in these 45 years. It can be concluded that Germany, with its current development trend in the coming years, will surpass the United States based on the number of articles and gain the first rank. Also, future studies can be conducted on respiratory diseases as the most important ODs and health care work as the most important job during the past years.
    Keywords:  epidemiology; occupational disease; occupational health; respiratory disease; scientometrics
    DOI:  https://doi.org/10.3389/fpubh.2022.1009203
  66. Commun Biol. 2022 Sep 29. 5(1): 1023
      Fossil material in amber from Myanmar can provide important insights into mid-Cretaceous forest ecosystems. However, Myanmar amber has been receiving increased international attention due to reported links between amber mining and the ongoing humanitarian crisis in northern Myanmar, as well as the legal issues associated with its exportation. Here, we conduct a bibliometric analysis of Myanmar amber publications (1990-2021) and demonstrate how research interest in Myanmar amber is explicitly linked to major political, legal, and economic changes. An analysis of the authorship networks for publications on amber inclusions reveals how current research practices have excluded Myanmar researchers from the field. In addition, the international trade of Myanmar amber with fossil inclusions falls into a legal 'grey-zone' which continues to be exploited. This case study vividly demonstrates that systemic changes, alongside an increased awareness of inequitable research practices amongst the broader scientific and allied communities, are urgently needed to curb illegal practices in palaeontology.
    DOI:  https://doi.org/10.1038/s42003-022-03847-2
  67. BMC Bioinformatics. 2022 Sep 30. 23(Suppl 8): 404
       BACKGROUND: Bioinformatics has gained much attention as a fast growing interdisciplinary field. Several attempts have been conducted to explore the field of bioinformatics by bibliometric analysis, however, such works did not elucidate the role of visualization in analysis, nor focus on the relationship between sub-topics of bioinformatics.
    RESULTS: First, the hotspot of bioinformatics has moderately shifted from traditional molecular biology to omics research, and the computational method has also shifted from mathematical model to data mining and machine learning. Second, DNA-related topics are bridge topics in bioinformatics research. These topics gradually connect various sub-topics that are relatively independent at first. Third, only a small part of topics we have obtained involves a number of computational methods, and the other topics focus more on biological aspects. Fourth, the proportion of computing-related topics hit a trough in the 1980s. During this period, the use of traditional calculation methods such as mathematical model declined in a large proportion while the new calculation methods such as machine learning have not been applied in a large scale. This proportion began to increase gradually after the 1990s. Fifth, although the proportion of computing-related topics is only slightly higher than the original, the connection between other topics and computing-related topics has become closer, which means the support of computational methods is becoming increasingly important for the research of bioinformatics.
    CONCLUSIONS: The results of our analysis imply that research on bioinformatics is becoming more diversified and the ranking of computational methods in bioinformatics research is also gradually improving.
    Keywords:  Bioinformatics; Knowledge structure; Text-mining; Visualization
    DOI:  https://doi.org/10.1186/s12859-022-04948-9
  68. Int J Legal Med. 2022 Sep 30.
      From its launc h in 1922 to the end of the Second World War, the Deutsche Zeitschrift für die gesamte gerichtliche Medizin spanned 38 volumes. The 1762 papers contained in those volumes reflect contemporary interests and include many papers from peripheral fields and non-medico-legal disciplines. Publications concerned with issues outside core legal medicine fields in particular allow two distinct tendencies in the development of German institutes of legal medicine to be discerned. Firstly, there is a focus on the psychological and psychiatric aspects of the discipline. Secondly, there is tendency towards a scientific-criminalistic outlook. The fatal consequences of the Nazi seizure of power in 1933 did not spare the sciences. For legal medicine, a discipline with close links to the state, it is unsurprising that fundamental changes to the political system had a significant impact on subject matter. Leaving aside articles notable principally for their ideological content, our analysis of the 38 volumes shows that the papers examined contain new insights into many subjects, some of which are still valid today.
    Keywords:  Academic articles; History of legal medicine; Official publications
    DOI:  https://doi.org/10.1007/s00414-022-02888-w
  69. J Affect Disord. 2022 Sep 26. pii: S0165-0327(22)01061-8. [Epub ahead of print]
       BACKGROUND: Although anxiety is highly prevalent in people with bipolar disorders and has deleterious impact on the course of the illness, past reviews have shown that many aspects of the topic remain under-researched. This scoping review aims to provide a comprehensive overview of the literature addressing anxiety in bipolar disorder (A-BD) between 2011 and 2020, assess if the interest in the topic has increased over the period and map the publication trends.
    METHODS: Three databases were systematically searched, and all articles were screened at the title/abstract and full text level based on inclusion and exclusion criteria. Of these, 1099 articles were included in the study. The annual number of articles on A-BD published between 2011 and 2020 was calculated and articles addressing it as a primary topic (n = 310) were classified into 4 categories and 11 subcategories to identify gaps in the knowledge.
    RESULTS: The results show no clear increase in the number of annual publications during the period and much of the available literature is of a descriptive nature. Less is known about the processes underlying the comorbidity and about treatment approaches.
    LIMITATIONS: Given the large scope of the research question, no quality assessment of the evidence was made. Only articles in English or French were considered.
    CONCLUSIONS: These results highlight the need to change the focus of research efforts to better understand and address this unique set of conditions in clinical settings.
    Keywords:  Anxiety; Anxious symptoms; Bipolar disorders; Comorbidity; Publication trends
    DOI:  https://doi.org/10.1016/j.jad.2022.09.057
  70. Appl Physiol Nutr Metab. 2022 Sep 29.
      The accuracy of books as public nutrition resources varies substantially; whether authors of publicly available nutrition books possess related experience, cite scientific evidence, or have other financial incentives has not been assessed thoroughly. This study aimed to determine if publicly available top-selling nutrition books are written by authors who (1) have relevant expertise, (2) cite scientific evidence, and (3) benefit financially in other ways. Best-selling nutrition books were gathered from Amazon Canada. Differences in scientific citations and financial incentives were compared between authors with and without credentials. Authors who were Doctor of Medicine (MD), registered dietitians (RD), chiropractors (DC), or naturopathic doctors (ND) had more in-text citations (56% versus 25%, p=0.014) and cited more scientific articles (83% versus 50%, p=0.0045) compared to all other authors. The majority of authors of publicly-available top-selling nutrition books in Canada did not have MD/RD credentials. Many of the authors promoted their own services or products, regardless of credentials.
    DOI:  https://doi.org/10.1139/apnm-2022-0051
  71. Expert Syst Appl. 2023 Mar 01. 213 118841
      The outbreak of COVID-19 brings almost the biggest explosions of scientific literature ever. Facing such volume literature, it is hard for researches to find desired citation when carrying out COVID-19 related research, especially for junior researchers. This paper presents a novel neural network based method, called citation relational BERT with heterogeneous deep graph convolutional network (CRB-HDGCN), for COVID-19 inline citation recommendation task. The CRB-HDGCN contains two main stages. The first stage is to enhance the representation learning of BERT model for COVID-19 inline citation recommendation task through CRB. To achieve the above goal, an augmented citation sentence corpus, which replaces the citation placeholder with the title of the cited papers, is used to lightly retrain BERT model. In addition, we extract three types of sentence pair according citation relation, and establish sentence prediction tasks to further fine-tune the BERT model. The second stage is to learn effective dense vector of nodes among COVID-19 bibliographic graph through HDGCN. The HDGCN contains four layers which are essentially all sub neural networks. The first layer is initial embedding layer which generates initial input vectors with fixed size through CRB and a multilayer perceptron. The second layer is a heterogeneous graph convolutional layer. In this layer, we expand traditional homogeneous graph convolutional network into heterogeneous by subtly adding heterogeneous nodes and relations. The third layer is a deep attention layer. This layer uses trainable project vectors to reweight the node importance simultaneously according to both node types and convolution layers, which further promotes the performance of learnt node vectors. The last decoder layer recovers the graph structure and let the whole network trainable. The recommendation is finally achieved by integrating the high performance heterogeneous vectors learnt from CRB-HDGCN with the query vectors. We conduct experiments on the CORD-19 and LitCovid datasets. The results show that compared with the second best method CO-Search, CRB-HDGCN improves MAP, MRR, P@100 and R@100 with 21.8%, 22.7%, 37.6% and 21.2% on CORD-19, and 29.1%, 25.9%, 15.3% and 11.3% on LitCovid, respectively.
    Keywords:  COVID-19 citation recommendation; Citation enhanced BERT; Deep graph convolutional network; Heterogeneous graph; Text representation learning
    DOI:  https://doi.org/10.1016/j.eswa.2022.118841
  72. Bioethics. 2022 Sep 28.
      Topic modeling-a text-mining technique often used to uncover thematic structures in large collections of texts-has been increasingly frequently used in the context of the analysis of scholarly output. In this study, we construct a corpus of 19,488 texts published since 1971 in seven leading journals in the field of bioethics and philosophy of medicine, and we use a machine learning algorithm to identify almost 100 topics representing distinct themes of interest in the field. On the basis of intertopic correlations, we group the content-based topics into eight clusters, thus providing a novel, fine-grained intellectual map of bioethics and philosophy of medicine. Moreover, we conduct a number of diachronic analyses, examining how the "prominence" of different topics has changed across time. In this way, we are able to observe the distinct patterns in which bioethics and philosophy of medicine have evolved and changed their focus over the past half a century.
    Keywords:  bioethics; distant reading; philosophy of medicine; topic modeling
    DOI:  https://doi.org/10.1111/bioe.13087
  73. AJR Am J Roentgenol. 2022 Sep 28.
      In academic medicine, the use of social media to share one's accomplishments has been considered important for various reasons including branding, self-promotion and advocacy, networking, raising of bibliometric metrics relating to one's articles, and, through these processes, facilitating overall academic advancement. However, social media engagement as a criterion for academic advancement and promotion lacks an evidence basis and can cause a variety of individual harms related to undue pressure, expectations, competition, and discomfort.
    DOI:  https://doi.org/10.2214/AJR.22.28287
  74. Sci Total Environ. 2022 Sep 22. pii: S0048-9697(22)06050-8. [Epub ahead of print] 158951
      Biological filtration has been widely used in wastewater treatment around the world, yet achieving satisfactory removal of pollutants remains a challenge due to the complexity of water pollution. In order to reveal the hotspots and trends of biological filtration from the perspective of research innovation, 5454 SCI papers and 14,287 patents collected from the Web of Science Core Collection and Derwent Innovation Index database were analyzed by visualization techniques. The results showed that China ranked first in the number of both papers and patents, while the USA and Japan contributed significantly in papers and patents, respectively. Co-occurrence analysis obtained the mapping knowledge domains and demonstrated distinct associations between contaminants ("nitrogen", "pharmaceuticals", "personal care products"), chemicals ("carbon", "activated carbon", "media"), process ("biodegradation", "adsorption" or "ozonation") and characteristics ("kinetics", "performance", "diversity"). Moreover, this review summarized the recent advances of biological filtration media, microorganism and combined process being applied. It was concluded that environmentally friendly biological filtration ("phytoremedi", "microalga", "recirculating aquaculture system"), bio-enhanced biological filtration ("bioaugment", "fungi", "low augment") and emerging pollutants ("emerging contamin", "antibiotic resistance gen", "organic micropollut", "trace organic chem") were the hotspots through data-driven analyses. Technology evolution path of biological filtration generally indicated the transition from conventional biological filtration for nitrogen and phosphorus removal to Fenton-biofiltration combined technology and finally to ozone-biological filtration. Furthermore, the technical innovation direction of the collaborative control of multi-media pollution, the low-carbon biological filtration and short-process technology was prospected. This work can serve as a quick reference for early-career researchers and industries working in the area of biological filtration.
    Keywords:  Biological filtration; Knowledge map; Patent analysis; Technology evolution path; Wastewater
    DOI:  https://doi.org/10.1016/j.scitotenv.2022.158951
  75. Front Public Health. 2022 ;10 883241
      With limited medical resources, it is of great significance for countries all over the world to explore architectural design methods to enhance the value of medical facilities. Therefore, it is very necessary to carry out an extensive international comparison. In order to grasp the research trend of healthcare facilities in the world, this paper conducts co-occurrence analysis, cluster analysis, and trend analysis of the keywords of 334 English articles and 153 Japanese articles related to healthcare facilities published in important academic journals in the USA and Japan in the past 15 years. We not only compare the similarities and differences in healthcare facility research between the USA and Japan, but also explore the reasons for these differences. It is found that by introducing three kinds of value variables, such as time, space, and behavior, we can not only well explain the difference in the solution of healthcare facilities in the USA and Japan to reduce medical costs but also provide new ideas for architectural design to enhance the value of hospitals. Based on the above analysis, a conceptual framework of value-based design of healthcare facilities that combines the advantages of the USA and Japan is proposed in this paper.
    Keywords:  Japan; USA; architectural planning; evidence-based design; healthcare facility; value-based design
    DOI:  https://doi.org/10.3389/fpubh.2022.883241
  76. Indian J Psychol Med. 2022 Sep;44(5): 493-498
       Background: Little is known about the publication outcomes of submissions rejected by specialty psychiatry journals. We aimed to investigate the publication fate of original research manuscripts previously rejected by the Indian Journal of Psychological Medicine (IJPM).
    Methods: A random sampling of manuscripts was drawn from all submissions rejected between January 1, 2018, and December 31, 2019. Using the titles of these papers and the author names, a systematic search of electronic databases was carried out to examine if these manuscripts have been published elsewhere or not. We extracted data on a range of scientific and nonscientific parameters from the journal's manuscript management portal for every rejected manuscript. Multivariable analysis was used to detect factors associated with eventual publication.
    Results: Out of 302 manuscripts analyzed, 139 (46.0%) were published elsewhere; of these, only 18 articles (13.0%) were published in a journal with higher standing than IJPM. Manuscripts of foreign origin (odds ratio [OR] 1.77, 95% confidence interval [CI] = 1.06-2.97) and rejection following peer review or editorial re-review (OR 2.41, 95% CI = 1.22-4.74) were significantly associated with publication.
    Conclusion: Nearly half of the papers rejected by IJPM were eventually published in other journals, though such papers are more often published in journals with lower standing. Manuscripts rejected following peer review were more likely to reach full publication status compared to those which were desk rejected.
    Keywords:  Desk rejection; Editorial policy; Peer review; Publication; Triage
    DOI:  https://doi.org/10.1177/02537176211046470
  77. J Am Psychiatr Nurses Assoc. 2022 Sep 28. 10783903221124160
       BACKGROUND: Identifying and sharing psychiatric mental health (PMH) research priorities can help identify gaps in the literature, determine training needs for nurses, and assist investigators in locating funding.
    AIMS: The aims for this project included: (1) identify PMH nursing specialty research priorities from large, public funding entities; (2) compare the identified research priorities and scholarly articles published in 2020; and (3) outline future directions for advancing the science of PMH nursing.
    METHODS: Strategic plans of funding entities for PMH research were reviewed for research priorities. Summarized priorities were then compared with publications from peer-reviewed PMH nursing journals. Work conducted in the United States was extracted and categorized as original research, evidence-based practice (EBP), or quality improvement (QI), then design and population.
    RESULTS: Priorities from 13 funding entities comprised three domains (education, research, and practice), with nine areas, 30 topics, and subtopics. Eight journals produced 432 articles with 99 (23%) conducted in the United States. Among these journals, publications fitting research priorities ranged from 1 to 33 articles. Of the 99 articles, 85% were original research and 15% were either EBP or QI. Descriptive articles comprised 64% and 23% tested interventions. Populations studied included workforce; adults; infants, children, and adolescents; and parents.
    CONCLUSIONS: All published articles by the U.S. PMH nurses matched the funding priorities, but not all funding priorities were addressed by 2020 publications. The majority of work was conducted outside of the United States and most published from the United States was descriptive, contrary to many United States funders' priorities for interventional research.
    Keywords:  evidence-based practice; quality improvement; research design and methodology
    DOI:  https://doi.org/10.1177/10783903221124160
  78. Waste Manag Res. 2022 Sep 29. 734242X221122556
      Food loss and waste have become an issue of global significance, considering their concurrent effects on the socioeconomic and environmental facet of society. Despite this domain gaining prolific attention recently, issues hampering the effective utilization of residues from fish processing usually go unidentified in developing economies such as India. This occurs mainly owing to fragmented supply chains, inappropriate handling, discontinuous cold chains, inadequate temperature monitoring and so on, affecting quality and causing underuse. Any researcher trying to understand the prospects of utilizing these fish processing co-streams in a developing economy with the vision of improving consumption, economic sustainability, reducing discards and promoting circularity faces a lacuna. The authors address this demand in research by identifying the validity of this domain both in the global and native research community by conducting a detailed review using bibliometric analysis and content analysis. Data from Scopus with 717 documents, comprising 612 research articles from 78 countries, 1597 organizations and 2587 authors, are analysed. Results signify (i) developing a focus on hydroxyapatite production, bio-methane generation, transesterification processes, biomass and the rest raw material generated from fish processing, and (ii) reduced research on supply chain-related aspects despite their considerable importance. To comprehend this deficiency, especially in the Indian stance, barriers hindering the utilization of generated by-products are identified, and recommendations for improvements are proposed. The results will provide the struts for a circular and sustainable supply chain for processed seafood in developing economies.
    Keywords:  Food waste; bibliometric analysis; processing co-streams; supply chain; waste management
    DOI:  https://doi.org/10.1177/0734242X221122556