bims-evares Biomed News
on Evaluation of research
Issue of 2023‒02‒26
eighty papers selected by
Thomas Krichel
Open Library Society
  1. Bibliometric study on the knowledge graph of immunotherapy for head and neck cancer.
  2. Assessing the publication output in the field of forensic science and legal medicine using Web of Science database from 2011 to 2020.
  3. Global research trends of hypertrophic cardiomyopathy from 2000 to 2022: Insights from bibliometric analysis.
  4. Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers.
  5. Global research trends in atherosclerosis-related NF-κB: a bibliometric analysis from 2000 to 2021 and suggestions for future research.
  6. Clubfoot from past to the present: A bibliometric analysis with global productivity and research trends.
  7. Top 100 most-cited articles on renal cell carcinoma: A bibliometric analysis.
  8. The model of descriptive, diagnostic, predictive, and prescriptive analytics on 100 top-cited articles of nasopharyngeal carcinoma from 2013 to 2022: Bibliometric analysis.
  9. A comprehensive bibliometric study of the balanced scorecard.
  10. Knowledge mapping of syringomyelia from 2003 to 2022: A bibliometric analysis.
  11. Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis.
  12. The interaction between microbiota and immune in intestinal inflammatory diseases: Global research status and trends.
  13. Original research on Behçet's syndrome: a bibliometric analysis over 20 years (2000-2019).
  14. The Evolution of Intelligence: Analysis of the Journal of Intelligence and Intelligence.
  15. Using chord diagrams to explore article themes in 100 top-cited articles citing Hirsch's h-index since 2005: A bibliometric analysis.
  16. Global productivity and research trends of colorectal carcinoma: A scientometric analysis of studies published between 1980 and 2021.
  17. A bibliometric analysis of primary immune thrombocytopenia from 2011 to 2021.
  18. Global research status and trends of bronchiectasis in children from 2003 to 2022: A 20-year bibliometric analysis.
  19. Bibliometric analysis of research articles on post-herpetic neuralgia published from 1991 to 2020.
  20. Emerging trends in gene and bipolar disorder research: a bibliometric analysis and network visualisation.
  21. Global historical retrospect and future prospects on biomarkers of heart failure: A bibliometric analysis and science mapping.
  22. Global trends in poliomyelitis research over the past 20 years: A bibliometric analysis.
  23. Analysis of the structure of scientific knowledge on wine tourism: A bibliometric analysis.
  24. Sustainable brownfield redevelopment and planning: Bibliometric and visual analysis.
  25. Trends in Autism Spectrum-Related Motherhood Research: A Bibliometric Study.
  26. Severe fever with thrombocytopenia syndrome virus trends and hotspots in clinical research: A bibliometric analysis of global research.
  27. Knowledge mapping of research on the mitochondrial unfolded protein response: a bibliometric and visual analysis.
  28. #OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery.
  29. Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis.
  30. Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022.
  31. Female Dynamics in Authorship of Scientific Publications in the Public Library of Science: A 10-year Bibliometric Analysis of Biomedical Research.
  32. Analysis of citation trends to identify articles on delirium worth reading using DDPP model with temporal heatmaps (THM): A bibliometric analysis.
  33. The status and trends of mitochondrial dynamics research: A global bibliometric and visualized analysis.
  34. The research landscape of the quality of life or psychological impact on gynecological cancer patients: A bibliometric analysis.
  35. A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease.
  36. Drug-Induced Cardiotoxicity in Children During the Past 30 Years: A Bibliometric Study and Visualization Analysis.
  37. The status of bladder cancer research worldwide, a bibliometric review and recommendations.
  38. A bibliometric analysis of apoptosis in glaucoma.
  39. A bibliometric and visual analysis of publications on artificial intelligence in colorectal cancer (2002-2022).
  40. Four decades of hand microsurgery in Iran: A bibliographic analysis.
  41. Visual analysis of image-guided radiation therapy based on bibliometrics: A review.
  42. A bibliometric review of 35 years of studies about preeclampsia.
  43. Who publishes imaging articles in non-imaging journals? A large sample data-mining study.
  44. A cross-sectional analysis identified co-authorship networks and scientific collaboration on reporting guidelines for health research.
  45. Evaluation of gender trends in first authorship in nephrology publications in four major US journals in the last decade.
  46. Dental Caries and Salivary Oxidative Stress: Global Scientific Research Landscape.
  47. The Issue of Gender Bias Represented in Authorship in the Fields of Exercise and Rehabilitation: A 5-Year Research in Indexed Journals.
  48. Nine decades of data on environmental chemical pollutant exposure in dogs: a bibliometric analysis.
  49. Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis.
  50. Knowledge domain and emerging trends in HIV-MTB co-infection from 2017 to 2022: A scientometric analysis based on VOSviewer and CiteSpace.
  51. Mapping the global research landscape on nutritional support for patients with gastrointestinal malignancy: visualization analysis.
  52. Honey's Antioxidant and Antimicrobial Properties: A Bibliometric Study.
  53. A bibliometric analysis of the role of microbiota in trauma.
  54. Immunotherapy in cervical cancer: From the view of scientometric analysis and clinical trials.
  55. A bibliometric analysis of research on tourism content marketing: Background knowledge and thematic evolution.
  56. Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells.
  57. The impact of brick kilns on environment and society: a bibliometric and thematic review.
  58. The Use of Facial Recognition Software and Published Manuscripts to Examine Trends in Surgical Editorial Board Diversity.
  59. A bibliometric analysis on traumatic brain injury in forensic medicine of a half-century (1972-2021).
  60. Wider indications and more efficient drug delivery: A bibliometric analysis and visualization of photodynamic therapy in skin cancer.
  61. A Bibliometric Analysis of Aging in COVID-19.
  62. Crafts as a key factor in local development: Bibliometric analysis.
  63. The role of open data in digital society: The analysis of scientific trending topics through a bibliometric approach.
  64. A Bibliometric Analysis on the Early Works of Dental Anxiety.
  65. Gene and schizophrenia in the pregenome and postgenome-wide association studies era: a bibliometric analysis and network visualization.
  66. Artificial Intelligence for Cancer Detection-A Bibliometric Analysis and Avenues for Future Research.
  67. A systematic review of urban green space research over the last 30 years: A bibliometric analysis.
  68. Visual analysis of greenhouse gas emissions from sewage treatment plants based on CiteSpace: from the perspective of bibliometrics.
  69. Research on artificial intelligence in shoulder and elbow surgery is increasing.
  70. The problem of miscitation in psychological science: Righting the ship.
  71. Association of Practice Setting and Scholarly Activity With Medicolegal Claims in Otolaryngology-Head and Neck Surgery.
  72. The Power of Cooperation: A Quantitative Analysis of the Benefit of Civilian Partnerships on the Academic Output of Military Surgeons.
  73. Empirical relationship between the number of review and research articles.
  74. Aesthetic value protection and tourism development of the world natural heritage sites: a literature review and implications for the world heritage karst sites.
  75. Trends in types of graduate degrees and research output for academic general surgeons in Canada.
  76. The most influential COVID-19 articles: A systematic review.
  77. Automatic identification of scientific publications describing digital reconstructions of neural morphology.
  78. Past and present: a bibliometric study on polycystic ovary syndrome.
  79. The NLM indexer assignment dataset: a new large-scale dataset for reviewer assignment research.
  80. Parkinson's disease research in Morocco: a review.
  1. Front Oncol. 2023 ;13 942777
    Bibliometric study on the knowledge graph of immunotherapy for head and neck cancer.
    Ji Wang, Zhengpeng Gong, Ming Yu.
      Background: Head and neck squamous cell carcinoma (HNSCC) is a common malignant tumor with a significant mortality rate, especially in patients at locally advanced stage, or with recurrence and metastasis. Immunotherapy has shown remarkable breakthrough in the treatment of locally advanced cancer, recurrence and metastasis in recent years. During this time, a large number of HNSCC immunotherapy studies have been published. However, few studies employed bibliometric analysis. This work analyzes HNSCC immunotherapy trends and hotspots using bibliometric analysis to get better understanding of the current state and future direction of HNSCC immunotherapy.Methods: Relevant articles and publications about immunotherapy of HNSCC were extracted from Web of Science Core Collection (WoSCC). Bibliometrics was used to study these publications in terms of countries/regions, institutions, authors (cited authors), journals (cited journals), references, and keywords, so as to identify research hotspots and to predict future research trends in this field.
    Results: A total of 1377 English articles published between 2000 and 2022 were collected. It is found that the number of articles increases rapidly from 2016. The United States has the largest number of publications (n=538), followed by China (n=407) and Germany (n=175). The institute with the highest published papers is the University of Pittsburgh (n=67). In terms of author, Robert L Ferris ranks first among the top ten cited authors. Oral Oncology (impact factor (IF) (2021) = 5.972) is the most prolific academic journal in immunotherapy of HNSCC. According to the reference cluster analysis, the research hot topic has shifted from basic research on immunotherapy of head and neck cancer to the study of prognosis. Keywords analysis also reveals that the study of patients' prognoses is at the core of immunotherapy for HNSCC.
    Conclusion: Currently, head and neck cancer research focus primarily on prognostic significance, cancer treatment, and poor prognosis. However, the researches on immunotherapy for head and neck malignancies is the growing trend in near future. Notably, United States has made significant contributions to this field.
    Keywords:  CiteSpace; Immunotherapy; VOSviewer; bibliometric study; head and neck cancer; head and neck squamous cell carcinoma
    DOI:  https://doi.org/10.3389/fonc.2023.942777
  2. Forensic Sci Res. 2022 ;7(4): 748-760
    Assessing the publication output in the field of forensic science and legal medicine using Web of Science database from 2011 to 2020.
    Bedirhan Sezer Öner, Metin Orbay.
      The aim of this study was threefold. First, it analyzed the characteristics of the publication outputs for the Legal Medicine (LM) category using the Web of Science (WoS) database during 2011-2020. Second, it discussed the distribution of the papers for the 25 most productive countries/regions in terms of quality and quantity, such as the h-index and GDP per capita. Finally, it investigated the trend and temporal stability of the journal impact factor (JIF) and determined the percentage of the journal self-citations. The findings suggested that the number of papers, the average number of pages of the papers, the average number of cited references in the papers, the average number of authors per paper, the percentage of open access papers, as well as international and domestic collaboration tended to increase regularly. However, the productivity was limited when compared to the whole WoS database, since there was no significant change in the number of the journals. The countries/regions with the highest number of publications were not those that made the most impact in terms of the widespread impact of the publications. The level of international cooperation and the funding for the research had dramatic impact on the visibility of papers. The average JIF has increased significantly while the journal self-citation rates have decreased in a similar way. The journals have had very stable (have not fluctuated) impact factors over time. During the period studied, the journals with the higher impact factors (Q1, Q2) published many more papers than journals with the lower impact factors (Q3, Q4).
    Keywords:  Bibliometrics; Web of Science; citation analysis; forensic science; legal medicine
    DOI:  https://doi.org/10.1080/20961790.2021.2002525
  3. Front Cardiovasc Med. 2023 ;10 1039098
    Global research trends of hypertrophic cardiomyopathy from 2000 to 2022: Insights from bibliometric analysis.
    Xifeng Zheng, Zhongkai He, Ming Li, Zhen Jia.
      Objectives: To analyze the global research trends of hypertrophic cardiomyopathy (HCM) from 2000 to 2022 and explore new frontiers in this field.Methods: We reviewed the literature in the Web of Science Core Collection database from January 2000 to August 2022 using the retrieval strategy of medical subject headings combined with text words. We focused on articles and reviews that were published in English. Relevant data of the target publications, such as title, authors, organizations, abstract, keywords, published date, journal, and number of citations, were collected. The R software with the "bibliometrix" and VOSviewer software was used to process and visualize the information.
    Results: Among a total of 20,581 records related to HCM, 13,427 from 103 countries and regions, 8,676 affiliations, and 46,645 researchers were included. Most of the publications in this field were from the United States, followed by Japan, the United Kingdom, and China. We also report the top 10 institutions and most influential researchers, cited articles, and highest-frequency keywords (echocardiography, heart failure, sudden cardiac death, genetics, atrial fibrillation, magnetic resonance imaging/cardiac magnetic resonance, prognosis, mutation, arrhythmia, late gadolinium enhancement). In addition, keywords trend analysis indicated that the novel medicine Mavacamten, genetic diagnosis, and cardiac magnetic resonance have attracted the most attention for the treatment and diagnosis of HCM over the past five years.
    Conclusion: The present study reports on the global research trends of HCM over the past two decades using bibliometric analysis. It may enlighten new frontiers in the diagnosis, treatment, and risk prevention of HCM.
    Keywords:  Mavacamten; bibliometric analysis; cardiac magnetic resonance; genetic diagnosis; hypertrophic cardiomyopathy; web of science
    DOI:  https://doi.org/10.3389/fcvm.2023.1039098
  4. Ann Transl Med. 2023 Jan 31. 11(2): 54
    Global trends in research on oxidative stress related to heart failure from 2012 to 2021: a bibliometric analysis and suggestion to researchers.
    Yan Pang, Mingjian Huang, Junshen Lu, Zhilin Peng, Meiling Tang, Puwei Huang, Yang Zhai, Jianqi Lu.
      Background: Oxidative stress leads to an increase in reactive oxygen in the body. During heart failure (HF), when the body's antioxidant defense system fails to remove excessive reactive oxygen species, myocardial cells will be damaged or even die. Over the past ten years, the number of research publications on oxidative stress related to HF has increased.Methods: We searched publications published in 2012-2021 and the Web of Science Core Collection (WoSCC) recording information. Based on the VOSviewer and CiteSpace, we conducted a bibliometric analysis of the overall distribution of journals, keywords, authors, major countries, annual output, active institutions, and cocited literature. The Global Citation Score (GCS) was used to evaluate the impact and quality of highly cited papers.
    Results: We retrieved 5,616 articles and reviews. Over the past ten years, the number of annual publications on oxidative stress related to HF has increased. USA has published the largest number of articles and obtained the highest number of citations (NC) and H-index. The University of California and PLoS One are the most productive affiliations and journals in terms of publications on oxidative stress related to HF. The GCS of articles written by Paulus WJ in 2013 was 1,632, which was the top ranking. The most frequent keywords are "oxidative stress", "heart failure", "inflammation", "dysfunction" and "apoptosis". The top three authors are Kang Yuming, Ren Jun and Okoshi Katashi. "Impact", "induced myocardial infarction", "cardiovascular outcome", "empagliflozin", "sglt2 inhibitor", "protect", and "Na+/H+ exchanger" have become popular research topics.
    Conclusions: Our research shows the research focus and development trends of oxidative stress related to HF in the past decade. Understanding the most important indicators of oxidative stress related to HF and the hot spots in the field of oxidative stress research related to HF can assist scholars, countries and policy-makers in the field in better understanding oxidative stress related to HF and can also lead to better decisions in oxidative stress treatment.
    Keywords:  Bibliometrics; CiteSpace; VOSviewer; heart failure (HF); oxidative stress
    DOI:  https://doi.org/10.21037/atm-22-6573
  5. Ann Transl Med. 2023 Jan 31. 11(2): 57
    Global research trends in atherosclerosis-related NF-κB: a bibliometric analysis from 2000 to 2021 and suggestions for future research.
    Bingyue Zhang, Mengyao Tian, Jinling Zhu, Aisong Zhu.
      Background: Atherosclerosis (AS) is closely related to stroke and cardiovascular diseases. Nuclear factor kappa-B (NF-κB) is the master regulator of inflammation, and thus, modulating the transcription of NF-κB can improve AS.Methods: In this study, we conducted a bibliometric analysis to identify the frontiers, hotspots, and features of global research output on NF-κB in AS from 2000 to 2021. Papers published from 2000 to 2021 and the recorded information were retrieved from the Science Citation Index-Expanded of the Web of Science Core Collection. Bibliometric analysis and visualization were performed using VOSviewer and CiteSpace, including an analysis of the general distribution of annual output, highly productive countries, active journals, active institutions and authors, keywords, and co-cited references.
    Results: A total of 5,439 original articles and reviews were retrieved and analyzed, and the results indicated that the annual number of publications on NF-κB in AS has been increasing in waves over the past 22 years. The majority of papers were published in China, while the USA had the highest number of citations and H-index. The most productive affiliation and journal were the University of California System and Arteriosclerosis Thrombosis and Vascular Biology, respectively. The papers of Chiu JJ. received the highest number of citations globally in 2011. The keywords, "nlrp3 inflammasome" and "microRNA", have recently attracted considerable attention, and very frequently occurring keywords included "NF kappa B", "atherosclerosis", "expression", "activation", "endogenous cell", and "oxidative stress". New keywords in 2021 included "muscle", "attenuates atherosclerosis", "mesenchymal transition", "metabolic disorder", and "palmitic acid".
    Conclusions: AS and inflammation have become research hotspots lately. Over the past decade, most studies have focused on basic research, and pathways associated with the regulatory role of NF-κB in AS have become a particular focus in recent studies. Moreover, our study revealed that NF-κB plays a remarkable role in AS and may be a therapeutic target.
    Keywords:  Bibliometrics; CiteSpace; VOSviewer; atherosclerosis (AS); nuclear factor kappa-B (NF-κB)
    DOI:  https://doi.org/10.21037/atm-22-6145
  6. Medicine (Baltimore). 2023 Feb 10. 102(6): e32803
    Clubfoot from past to the present: A bibliometric analysis with global productivity and research trends.
    Hakan Yolaçan, Serkan Güler, Ramadan Özmanevra.
      Clubfoot, a common congenital abnormality, affects the lower extremities; however, the literature search revealed no bibliometric research on this subject. Thus, we aimed to holistically analyze scientific articles and reveal global productivity and trend issues. This study statistically analyzed 1417 published articles on clubfoot (1980-2021) from the Web of Science database. Bibliometric network visualization maps were created to reveal trend topics, citation analysis, and cross-country collaborations. The analysis was conducted using Spearman correlation analysis. An exponential smoothing estimator was used to predict article productivity. The United States of America (433, 30.5%), the United Kingdom (166, 11.7%), and India (107, 7.5%) are the top 3 countries contributing to the literature. The Journal of Pediatric Orthopedics (220 articles), the Journal of Pediatric Orthopedics-Part B (147 articles), and Clinical Orthopedics and Related Research (69 articles) are the top 3 most productive journals. Dobbs MB (34 articles) is the most active author, and Shriners Hospital Children (44 articles) is the most active institution. Bibliometric analysis revealed that recently studied trend topics included Pirani score, Dimeglio score, Ponseti method, Ponseti casting, tenotomy, recurrence, neglected, tendon transfer, bracing, gait, risk factors, pedobarography, complex clubfoot, and polymorphism. The most studied subjects included Ponseti technique, treatment/casting, recurrent/relapsed clubfoot, Pirani score, pediatrics/children, foot deformities, surgery, ultrasound, Achilles tendon/tenotomy, gait analysis, casting, outcomes, neglected clubfoot, and tenotomy. Research leadership was determined in the western and European countries and Canada in studies and scientific collaborations on clubfoot; its impact was remarkable in India, China, and Turkey.
    DOI:  https://doi.org/10.1097/MD.0000000000032803
  7. Medicine (Baltimore). 2023 Feb 10. 102(6): e32926
    Top 100 most-cited articles on renal cell carcinoma: A bibliometric analysis.
    Huiyu Zhou, Fan Cui, Dingyang Lv, Qian Gong, Jie Wen, Weibing Shuang.
      BACKGROUND: To analyze the top 100 most-cited articles on renal cell carcinoma (RCC) using bibliometric methods based on the Web of Science core collection database and to explore the research status, hotspots, and emerging trends in RCC.METHODS: The literature on RCC was searched in the Web of Science core collection database using a specific search strategy, and the types of literature were limited to articles and reviews, with no restrictions to language and publication date. The top 100 articles with the highest number of citations were extracted after the manual screening. The publication year, the number of citations, authors, country, institution, journal, and keywords of these articles were collected and analyzed. Descriptive statistics and visual analysis were performed using Microsoft Excel, VOSviewer, CiteSpace, R, and SPSS.
    RESULTS: The number of citations of the top 100 articles varied from 541 to 4530, with a median citation count of 807.5, and the citation rates ranged from 13.8 to 448.4 citations per year. Motzer RJ (n = 22), Escudier B (n = 13), Rini BI (n = 13), and Hutson TE (n = 11) were major contributors to this research area, with Motzer RJ publishing 16 articles as the first author. The US (n = 73), France (n = 5), Canada (n = 4), and Sweden (n = 4) were the leading countries for RCC studies. MEMORIAL SLOAN KETTERING CANCER CENTER (n = 22) was the institution with the highest number of publications. These 100 articles were derived from 24 journals, and the New England Journal of Medicine had the largest number of articles published (n = 18, impact factor = 91.245). The keyword co-occurrence network analysis showed that research hotspots in this field included molecular mechanisms of RCC development and progression, surgical treatment, targeted drug-related clinical trials, and immunotherapy.
    CONCLUSION: We analyzed the top 100 articles with the highest number of citations in the field of RCC and identified the influential authors, countries, institutions, and journals in this field. This study also presented the current research status, hotspots, and future trends in RCC.
    DOI:  https://doi.org/10.1097/MD.0000000000032926
  8. Medicine (Baltimore). 2023 Feb 10. 102(6): e32824
    The model of descriptive, diagnostic, predictive, and prescriptive analytics on 100 top-cited articles of nasopharyngeal carcinoma from 2013 to 2022: Bibliometric analysis.
    Chung-Chia Hung, Mei-Yu Tu, Tsair-Wei Chien, Cheng-Yao Lin, Julie Chi Chow, Willy Chou.
      BACKGROUND: Nasopharyngeal carcinomas (NPCs) are prevalent in southeast Asia. There is a need to systematically review the current trend and status of NPC research. However, most bibliometric analyses have tended to focus on descriptive and diagnostic analytics rather than predictive and prescriptive analyses. Thus, it is necessary to use the model of the 4 (called the descriptive, diagnostic, predictive, and prescriptive analytics [DDPP]) to derive insights from the data. This study aimed to apply the DDPP model to classify article themes and illustrate the characteristics of NPCs; compare NPC researcher achievements across countries, institutes, departments, and authors; determine whether the mean citations of keywords can be used to predict article citations; and highlight articles that are worthy of reading.METHODS: The Web of Science Core Collection was searched for 100 top-cited articles and reviews related to NPCs published between 2013 and 2022. As part of Microsoft Office Excel 2019, Visual Basic for Applications was used to illustrate the number of publications and scientific productivity of authors over time and to generate network/temporal heatmaps, chord/Sankey diagrams, radar/impact beam plots, and scatter/pyramid charts about collaborations among countries. The DDPP model identifies institutions, authors, and hotspots of NPC research. The category, journal, authorship, and L-index (CJAL) score was applied to evaluate individual research achievements.
    RESULTS: A total of 10,564 publications were extracted from Web of Science Core Collection and screened for 100 top-cited articles and reviews related to NPCs. Despite having the highest number of publications (36%), China lags slightly behind the US in CJAL scores. CJAL was higher at Sun Yat-Sen University, Radiat Oncol department, and author Jun Ma from China. The number of article citations was significantly correlated with the number of weighted keywords (F = 1791.17; P < .0001). Six articles with significantly increasing citations over the last 4 years were recommended.
    CONCLUSION: This bibliometric study utilizes the DDPP model to analyze the scientific progress of NPC over the past decade. The whole genome is a hot topic that may prove to be a promising research area in the future. A temporal heatmap may serve as a tool for providing readers with articles that are worth reading, which could lead to additional research in bibliometrics.
    DOI:  https://doi.org/10.1097/MD.0000000000032824
  9. Eval Program Plann. 2023 Feb 10. pii: S0149-7189(23)00033-2. [Epub ahead of print]97 102256
    A comprehensive bibliometric study of the balanced scorecard.
    Carlos Suárez-Gargallo, Patrocinio Zaragoza-Sáez.
      This research provides a deeper knowledge in the Balanced Scorecard (BSC) insight by using the bibliometric technique. The existing gap between the traditional literatura reviews and previous bibliometric studies, is covered as it is the first comprehensive analysis carried out in applying quantity, quality, and structural indicators. Web of Science Core Collection was used as the source of information, considering it the most accurate and suitable data base for these studies. This research covers the wider period-of-time possible, from 1992 to 2020, with a final sample of 771 articles in 466 reviews. Quantity indicators show the high interest that the BSC still has in the scholar's community, pointing out Kaplan and Norton as the most productive authors,and confirming that 'management', 'business' and 'accountability' are its most common field of activity, although others as 'systems' and sustainability' are coming to prominence; 'Balanced Scorecard' appears as the most remarkable keyword. Quality indicators found 32,706 citations, with Kaplan and Norton occupying again top positions as well as 'Harvard Business Review' as the most impacting review both in cited articles and in average. Co-citation analysis reveals the existence of a triple corecluster for articles, based on the theory, literature reviews, and case-studies.
    Keywords:  Balanced scorecard; Bibliometric; Bibliometric analysis; Citation analysis; Cocitation; Web of Science
    DOI:  https://doi.org/10.1016/j.evalprogplan.2023.102256
  10. J Clin Neurosci. 2023 Feb 21. pii: S0967-5868(23)00004-8. [Epub ahead of print]110 63-70
    Knowledge mapping of syringomyelia from 2003 to 2022: A bibliometric analysis.
    Junyong Wu, Shuxin Ji, Pengyuan Niu, Binbin Zhang, Dongqi Shao, Yu Li, Shan Xie, Zhiquan Jiang.
      BACKGROUND: Syringomyelia is a chronic, progressive disease of the spinal cord. Syringomyelia is an etiologically diverse affliction caused by disturbance of normal cerebrospinal fluid flow dynamics. Lesions are characterized by the formation of tubular cavities in the gray matter of the spinal cord and gliosis; however, the etiology is unknown and treatment methods differ. Many existing studies have focused on the relationship between other diseases and syringomyelia. There is a lack of comprehensive and objective reports on the research status of syringomyelia. Therefore, this study aimed to conduct a bibliometric analysis to quantify studies on Syringomyelia and trending issues in the last 20 years.METHODS: Articles were acquired from the Web of Science Core Collection database. We used the Library Metrology online analysis platform, BICOMB, gCLUTO, CiteSpace bibliometrics tools for analysis, VOSviewer 1.6.16 (Nees Jan van Eck and Ludo Waltman, 2010), and Microsoft Excel 2019 to perform bibliometric analysis and visualization. Individual impact and collaborative information were quantified by analyzing annual publications, journals, co-cited journals, countries/regions, institutions, authors, and co-cited authors. We then identified the trending research areas of syringomyelia by analyzing the co-occurrence of keywords and co-cited references.
    RESULTS: From January 2003 to August 2022, 9,556 authors from 66 countries published a total of 1,902 research articles on syringomyelia in 518 academic journals. Most publications come from the United States, China, the United Kingdom, and Japan, with the United States dominating. Nanjing University and the University of Washington are the most active institutions, Dr. Claire Rusbridge has published the most papers, and Miholat has the most co-citations. The Journal of Neurosurgery has the highest number of co-cited articles, which are mainly in the fields of neurology, surgery, and biology. High-frequency keywords included syringomyelia, Chiari-I malformation, children, surgical treatment, and spinal cord.
    CONCLUSIONS: The number of articles on syringomyelia has increased steadily over the past two decades. At present, research on syringomyelia is mainly focused on the age of onset, potential therapeutic interventions, surgical treatment, avoidance of recurrence, and delay of pain. The use of surgical treatment of the disease and the mechanism of further treatment are the current hot research topics. The correlation between trauma and congenital factors, translational application, the effect of surgical treatment, postoperative recurrence, and complications are further hot research areas. These may provide ideas for further research into a radical cure for syringomyelia.
    Keywords:  BICOMB; Bibliometric; Citation; CiteSpace; Syringomyelia; VOSviewer; gCLUTO；Web of Science
    DOI:  https://doi.org/10.1016/j.jocn.2023.01.004
  11. Front Physiol. 2023 ;14 1123582
    Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis.
    Victoria Anthony Uyanga, Taha H Musa, Oyegunle Emmanuel Oke, Jingpeng Zhao, Xiaojuan Wang, Hongchao Jiao, Okanlawon M Onagbesan, Hai Lin.
      Background: Heat stress remains a major environmental factor affecting poultry production. With growing concerns surrounding climate change and its antecedent of global warming, research on heat stress in poultry has gradually gained increased attention. Therefore, this study aimed to examine the current status, identify the research frontiers, and highlight the research trends on heat stress in poultry research using bibliometric analysis. Methods: The literature search was performed on the Web of Science Core Collection database for documents published from 2000 to 2021. The documents retrieved were analyzed for their publication counts, countries, institutions, keywords, sources, funding, and citation records using the bibliometric app on R software. Network analysis for co-authorship, co-occurrence, citation, co-citation, and bibliographic coupling was visualized using the VOSviewer software. Results: A total of 468 publications were retrieved, and over the past two decades, there was a gradual increase in the annual number of publications (average growth rate: 4.56%). China had the highest contribution with respect to the number of publications, top contributing authors, collaborations, funding agencies, and institutions. Nanjing Agricultural University, China was the most prolific institution. Kazim Sahin from Firat University, Turkey contributed the highest number of publications and citations to heat stress in poultry research, and Poultry Science was the most productive and the most cited journal. The top 10 globally cited documents mainly focused on the effects of heat stress, alleviation of heat stress, and the association between heat stress and oxidative stress in poultry. All keywords were grouped into six clusters which included studies on "growth performance", "intestinal morphology", "heat stress", "immune response", "meat quality", and "oxidative stress" as current research hotspots. In addition, topics such as; "antioxidants", "microflora", "intestinal barrier", "rna-seq", "animal welfare", "gene expression", "probiotics", "feed restriction", and "inflammatory pathways" were identified for future research attention. Conclusion: This bibliometric study provides a detailed and comprehensive analysis of the global research trends on heat stress in poultry over the last two decades, and it is expected to serve as a useful reference for potential research that will help address the impacts of heat stress on poultry production globally.
    Keywords:  VOSviewer; bibliometric; chickens; growth performance; heat stress; oxidative stress
    DOI:  https://doi.org/10.3389/fphys.2023.1123582
  12. Front Cell Infect Microbiol. 2023 ;13 1128249
    The interaction between microbiota and immune in intestinal inflammatory diseases: Global research status and trends.
    Chuan Liu, Wenhao Su, Zongbiao Tan, Jixiang Zhang, Weiguo Dong.
      Aims: This study aimed to conduct a bibliometric analysis of the relevant literature on the interaction between microbiota and immune in intestinal inflammatory diseases, and show its current status, hotspots, and development trends.Methods: The related literature was acquired from the Web of Science Core Collection on October 12, 2022. Co-occurrence and cooperation relationship analysis of authors, institutions, countries, references, and keywords in the literature were carried out through CiteSpace 6.1.R3 software and the Online Analysis platform of Literature Metrology. At the same time, the relevant knowledge maps were drawn, and the keywords cluster analysis and emergence analysis were performed.
    Results: 3,608 related publications were included, showing that the number of articles in this field is increasing year by year. The results showed that Gasbarrini A and Sokol H were the authors with the highest cumulative number of articles with 25, and the institution with the most articles was Harvard University with 142 articles. The USA was far ahead in the article output, with 1,131 articles, and had a dominant role, followed by China with 707 articles. The journal Frontiers in Immunology contributed the most to this research field with 213 articles. In the cooperation network analysis, the USA, Harvard University, and Xavier RJ were the most widely collaborated country, institution, and author, respectively, which implied a high level of influence. Keywords analysis showed that there were 770 keywords, which were mainly classified as internal related diseases, such as "inflammatory bowel disease", "irritable bowel syndrome", "colorectal cancer", and the mechanism of interaction of microbiota and immune, such as "intestinal microbiota", "commensal microbiota", "regulatory T cell", "dendritic cell", "barrier function", "activation", "anti-inflammatory properties", "intestinal epithelium", and "diversity". Emerging analysis showed that future research hotspots and trends might be the short-chain fatty acid, gut dysbiosis, gut-liver axis, and fusobacterium nucleatum.
    Conclusion: This research was the first bibliometric analysis of publications in the field of interaction between microbiota and immune in intestinal inflammatory diseases using visualization software and data information mining, and obtained the current status, hotspots, and development of this field, which provides a theoretical basis for its scientific research.
    Keywords:  CiteSpace; bibliometric; immune; intestinal inflammatory diseases; microbiota
    DOI:  https://doi.org/10.3389/fcimb.2023.1128249
  13. Clin Exp Rheumatol. 2023 Feb 14.
    Original research on Behçet's syndrome: a bibliometric analysis over 20 years (2000-2019).
    Eleana Bolla, Katerina Chatzidionysiou, Maria G Tektonidou, Petros P Sfikakis.
      OBJECTIVES: To perform a bibliometric analysis of original research articles on Behçet's syndrome (BS) published over the last 20 years prior to the COVID-19 pandemic, and to systematically describe their characteristics and citation records.METHODS: PubMed database was searched for any article published on BS between 2000 and 2019. We identified all original research articles and categorised them by country of origin and type of research, i.e., clinical, translational and basic. Each article's impact was assessed using the individual citation numbers from Google Scholar search engine; we also calculated the median annual citation rates (ACRs), both per country and research type.
    RESULTS: Of a total of 2,381 retrieved original articles from 51 countries, the majority reported on clinical (52.6%), followed by translational (46.0%) and basic research (1.4%). Turkey had the highest number of publications (39% of articles) followed by four countries (Korea, China, Japan, Italy) where BS is also relatively prevalent. However, regarding median ACRs, France was first, followed by United Kingdom, Germany and Collaboration. Although the number of articles has almost doubled between 2010-2019 versus 2000-2009, median ACRs across either clinical or translational research had a downwards trend.
    CONCLUSIONS: Researchers from countries where BS is prevalent are more productive, albeit their work is of lower impact compared to countries with generally higher research budgets. A considerable increase of original research articles on BS is observed over time but further funding may be warranted for a parallel increase in the respective scientific impact.
    DOI:  https://doi.org/10.55563/clinexprheumatol/rq72g6
  14. J Intell. 2023 Feb 14. pii: 35. [Epub ahead of print]11(2):
    The Evolution of Intelligence: Analysis of the Journal of Intelligence and Intelligence.
    Fabio Andres Parra-Martinez, Ophélie Allyssa Desmet, Jonathan Wai.
      What are the current trends in intelligence research? This parallel bibliometric analysis covers the two premier journals in the field: Intelligence and the Journal of Intelligence (JOI) between 2013 and 2022. Using Scopus data, this paper extends prior bibliometric articles reporting the evolution of the journal Intelligence from 1977 up to 2018. It includes JOI from its inception, along with Intelligence to the present. Although the journal Intelligence's growth has declined over time, it remains a stronghold for traditional influential research (average publications per year = 71.2, average citations per article = 17.07, average citations per year = 2.68). JOI shows a steady growth pattern in the number of publications and citations (average publications per year = 33.2, average citations per article = 6.48, total average citations per year = 1.48) since its inception in 2013. Common areas of study across both journals include cognitive ability, fluid intelligence, psychometrics-statistics, g-factor, and working memory. Intelligence includes core themes like the Flynn effect, individual differences, and geographic IQ variability. JOI addresses themes such as creativity, personality, and emotional intelligence. We discuss research trends, co-citation networks, thematic maps, and their implications for the future of the two journals and the evolution and future of the scientific study of intelligence.
    Keywords:  bibliometric analysis; intelligence; scientometrics
    DOI:  https://doi.org/10.3390/jintelligence11020035
  15. Medicine (Baltimore). 2023 Feb 22. 102(8): e33057
    Using chord diagrams to explore article themes in 100 top-cited articles citing Hirsch's h-index since 2005: A bibliometric analysis.
    Yei-Soon Lee, Julie Chi Chow, Tsair-Wei Chien, Willy Chou.
      BACKGROUND: The h-index is increasingly being used as a measure of individual research achievement (IRA). More than 4876 citing articles have been published and indexed in Web of Science. The articles citing the h-index that have made the greatest contribution to scientific academics are still unknown. It is also unclear which subject categories (SCs) can be classified based on their keywords.METHODS: These 4976 citing articles have been collected from the Web of Science since 2005. SCs were classified using chord diagrams to visualize their associations of SCs and documents in 100 top-cited articles (T100hciting). In addition to chord diagrams, 6 visualizations were used to illustrate study results: choropleth maps were used to depict the geographical distribution of publications across countries, network diagrams were created by using coword analysis, box plots were created to complement the network diagrams, Sankey diagrams highlighted the 5 most important elements in each article entity, the dot plot was used for displaying T100hciting, and a radar plot was used to present the top 10 high-IRA elements of countries, institutes, departments, and authors based on category, journal impact factor, authorship, and L-index scores.
    RESULTS: A coword cluster analysis indicates that the majority of articles come from the US (918, 18%) and China (603, 12%), the top 2 SCs are h-index and bibliometric analysis, and the top 5 countries account for 55% in T100hciting, such as the US (25%), Spain (10%), Netherlands (9%), China (6%), and Belgium (5%). In T100hciting, 4 SCs are included, namely, the h-index (72%), bibliometric analysis (24%), physics & multidisciplinary (3%), and infectious diseases (1%).
    CONCLUSION: A total of 7 visualizations were used to display the results in this study. Chord diagrams are suggested as a tool for future bibliographical studies to classify SCs Future bibliometrics with chord diagrams should not be limited to the topic of h-index-citing articles, as we did in this study.
    DOI:  https://doi.org/10.1097/MD.0000000000033057
  16. Medicine (Baltimore). 2023 Feb 22. 102(8): e33037
    Global productivity and research trends of colorectal carcinoma: A scientometric analysis of studies published between 1980 and 2021.
    İbrahim Tayfun Şahiner, Çetin Altunal.
      Although colorectal cancer (CRC) is a serious cause of death and has a significant impact on patients' quality of life and incidence rate of CRC has increased among the younger populations, bibliometric research of CRC has not been conducted yet. To perform a comprehensive analysis of scientific publications on CRC using various statistical and bibliometric techniques. Publications on CRC published between 1980 and 2021 were downloaded from the Web of Science database and analyzed using statistical methods. The trending topics, collaborations among countries, and citation relationships were analyzed using bibliometric network visualization mapping. The number of articles to be probably published in the next 5 years was estimated using the exponential smoothing estimator. The Spearman's correlation rank correlation coefficient was used to analyze the correlations among the variables. A total of 122,717 publications were found in the fields of oncology, gastroenterology, hepatology, and surgery. Of the published articles, 64,774 publications were research articles. The top five countries that contributed the most to the literature were the USA (16,604; 25.6%), China (10,567; 16.3%), Japan (7932; 12.2%), the UK (5009; 7.1%), and Italy (4287; 6.6%). The most prolific author, institution, and journal in the field of CRC were Zhang Y (n = 331), University of Texas System (n = 1646), and Diseases of the Colon and Rectum (n = 2090), respectively. The most influential journal based on the average number of citations received per article was CA-A Cancer Journal for Clinicians (citations per article; 286). There was a significant positive correlation between the number of articles produced by the countries on CRC and gross domestic product and human development index (r = 0.726, P < .001; r = 0.658, P < .001, respectively). Additionally, a significant moderate correlation of CRC was found with gross domestic product per capita (r = 0.711, P < .001). Keywords like overall survival, neoadjuvant chemoradiotherapy, locally advanced rectal cancer, robotic surgery, anastomotic leakage, chemoradiotherapy, metastatic colorectal cancer, KRAS, meta-analysis, colorectal surgery, and laparoscopic surgery were studied.
    DOI:  https://doi.org/10.1097/MD.0000000000033037
  17. Br J Haematol. 2023 Feb 20.
    A bibliometric analysis of primary immune thrombocytopenia from 2011 to 2021.
    Yang Ou, Yanxia Zhan, Xibing Zhuang, Xia Shao, Pengcheng Xu, Feng Li, Hao Chen, Lili Ji, Yunfeng Cheng.
      Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by isolated thrombocytopenia. This bibliometric analysis was applied to identify the characteristics of global scientific output, the hotspots, and frontiers of ITP over the past 10 years. We retrieved publications from 2011 to 2021 from the Web of Science Core Collection (WoSCC). Bibliometrix package, VOSviewer, and Citespace were used to analyse and visualize the trend, distribution, and hotspots of research on ITP. Altogether, there were 2084 papers, written by 9080 authors from 410 organizations in 70 countries/regions, published in 456 journals with 37 160 co-cited references. In the last decades, the most productive journal was British Journal of Haematology, China was the most productive country. and the most cited journal was Blood. Shandong University was the most productive institution in the field of ITP. NEUNERT C, 2011, BLOOD, CHENG G, 2011, LANCET, and PATEL VL, 2012, BLOOD were the top three most cited documents. "Thrombopoietin receptor agonist", "regulatory T cell" and "sialic acid" were three hotspots of the last decade. And "immature platelet fraction", "Th17", and "fostamatinib" would be research frontiers in the feature. The present study provided a novel insight for future research directions and scientific decision-making.
    Keywords:  bibliometric analysis; fostamatinib; primary immune thrombocytopenia; regulatory T cell; thrombopoietin receptor agonist
    DOI:  https://doi.org/10.1111/bjh.18692
  18. Front Pediatr. 2023 ;11 1095452
    Global research status and trends of bronchiectasis in children from 2003 to 2022: A 20-year bibliometric analysis.
    Ting Gong, Xueer Wang, Shuanglian Li, Li Zhong, Lin Zhu, Tingting Luo, Daiyin Tian.
      Background: This study aims to analyze the research hotspots, evolution, and developing trends in pediatric bronchiectasis over the past 20 years using bibliometric analysis and visualization tools to identify potential new research directions.Methods: Publications related to bronchiectasis in children were retrieved from the Web of Science Core Collection (WoSCC) database from 2003 to 2022. Knowledge maps were performed through VOSviewer1.6.18 and CiteSpace6.1 R2.
    Results: A total of 2,133 publications were searched, while only 1,351 original articles written in English between 2003 and 2022 were incorporated. After removing duplicates, we finally included 1,350 articles published by 6,593 authors from 1,865 institutions in 80 countries/regions in 384 different academic journals with an average citation frequency of 24.91 times. The number of publications shows an extremely obvious binomial growth trend. The majority of publications originated from the United States, Australia, and England. The institutes in Australia, especially Charles Darwin University, published the most articles associated with pediatric bronchiectasis. In addition, Pediatric Pulmonology was the most published journal. In terms of authors, Chang AB was the most productive author, while Gangell CL had the highest average citation frequency. The five keywords that have appeared most frequently during the last two decades were "children," "cystic fibrosis," "bronchiectasis," "ct," and "pulmonary-function." According to keyword analysis, early diagnosis and intervention and optimal long-term pediatric-specific management were the most concerned topics for researchers.
    Conclusion: This bibliometric analysis indicates that bronchiectasis in children has drawn increasing attention in the last two decades as its recognition continues to rise, providing scholars in the field with significant information on current topical issues and research frontiers.
    Keywords:  CiteSpace; VOSviewer; bibliometric; bronchiectasis; children; hotspot; pediatrics
    DOI:  https://doi.org/10.3389/fped.2023.1095452
  19. Medicine (Baltimore). 2023 Feb 10. 102(6): e32967
    Bibliometric analysis of research articles on post-herpetic neuralgia published from 1991 to 2020.
    Jeongsoo Kim, Hyeon Cheun, Jeong Jeong, Ho-Jin Lee.
      Post-herpetic neuralgia (PHN) is one of the most painful diseases, which has made it a major concern for pain physicians. We aimed to quantitatively analyze the research outputs of studies on PHN published over the past 30 years using bibliometric analysis. We also aimed to analyze the research outputs of studies on interventional treatments for PHN and evaluate the academic achievements of Korean pain physicians. Bibliometric analysis was performed by searching the Web of Science database for PHN-related articles published between 1991 and 2020. Publication number, year, source, country, institution, and citation-related information were retrieved from the database. We also quantitatively analyzed publications related to interventional treatments for PHN. A total of 3285 publications were extracted from the database; 101 (3.1%) of the articles were published by South Korean authors, making South Korea the 11th in the order of countries that published the most articles. There were 185 articles on the effects of interventional treatments for PHN. South Korean authors published 30 (16.2%) articles out of these, making South Korea the 3rd in the order of countries that published the most articles on the effects of interventional treatment for PHN. Our results showed an increasing trend in the number of PHN-related publications and the academic achievements of Korean pain physicians in this field over the past 3 decades. However, the proportion of studies on interventional treatments is relatively small. Korean pain physicians need to establish academic evidence on interventional treatment to expand their role in this field and improve the outcomes of PHN patients.
    DOI:  https://doi.org/10.1097/MD.0000000000032967
  20. Psychiatr Genet. 2023 Feb 24. pii: e000338. [Epub ahead of print]
    Emerging trends in gene and bipolar disorder research: a bibliometric analysis and network visualisation.
    Wan Nur Amalina Zakaria, Adi Wijaya, Badriya Al-Rahbi, Asma Hayati Ahmad, Rahimah Zakaria, Zahiruddin Othman.
      This study aims to use a bibliometric technique to evaluate the scientific output of gene and bipolar disorder research. The search query related to gene and bipolar disorder from the Scopus database identified 1848 documents from 1951 to 2020. The growth in the publications increased since early 1990, peaked in 2011, and started to decline thereafter. High occurrence in author keywords suggests that some research topics, such as "polymorphism", "linkage" and "association study" have waned over time, whereas others, such as "DNA methylation," "circadian rhythm," "" and "meta-analysis," are now the emerging trends in gene and bipolar disorder research. The USA was the country with the highest production followed by the UK, Canada, Italy and Germany. The leading institutions were Cardiff University in the UK, the National Institute of Mental Health (NIMH) in the USA, King's College London in the UK and the University of California, San Diego in the USA. The leading journals publishing gene and bipolar literature were the American Journal of Medical Genetics Neuropsychiatric Genetics, Molecular Psychiatry and Psychiatric Genetics. The top authors in the number of publications were Craddock N, Serretti A and Rietschel M. According to the co-authorship network analysis of authors, the majority of the authors in the same clusters were closely linked together and originated from the same or neighbouring country. The findings of this study may be useful in identifying emerging topics for future research and promoting research collaboration in the field of genetic studies related to bipolar disorder.
    DOI:  https://doi.org/10.1097/YPG.0000000000000338
  21. Heliyon. 2023 Feb;9(2): e13509
    Global historical retrospect and future prospects on biomarkers of heart failure: A bibliometric analysis and science mapping.
    Xin Dong, Yafei Xie, Jianguo Xu, Yu Qin, Qingyong Zheng, Rui Hu, Xin Zhang, Wenxin Wang, Jinhui Tian, Kang Yi.
      Introduction: Heart failure is a rapidly growing public health problem and has become a major cause of hospitalization in middle-aged and older adults. Biomarkers are clinically important in managing heart failure and have attracted more attention from researchers in recent years. This study aimed to evaluate the global research of heart failure biomarkers by bibliometrics and to identify the hot spots and perspectives for further advancement.Methods: Selection of relevant documents was from the Web of Science Core Collection. Microsoft Excel, VOSviewer, SciMA, and CiteSpace software were used for bibliometric analysis.
    Results: As of October 29, 2021, 5,978 documents for heart failure biomarkers have been identified from 1989 to 2021. European Journal of Heart Failure and Circulation respectively ranked first in terms of the number of publications and the number of co-citations. A total of 5,698 institutions from 90 countries participated in these publications, with the USA leading with 2,045 documents. The most productive institution was Harvard University. Januzzi, J.L. and Maisel, A.S. were the most productive and most cited authors respectively. Natriuretic peptide, copeptin, valsartan, ferric carboxymaltose, empagliflozin, preserved ejection fraction, myocardial fibrosis, and heart transplantation were hot themes.
    Conclusions: Extensive national and inter-institutional collaboration should be enhanced to bridge the gap between developed and less developed countries in heart failure biomarkers research. The research in this field seems to have reached a relatively mature stage, with a decrease in research fervor in recent years. The study of the natriuretic peptide family still has high centrality, with advances in the study of expression products and inflammatory markers. Cardiac fibrosis, cardiac remodeling, and therapies regarding heart failure have become hot spots.
    Keywords:  Bibliometric analysis; Biomarker; Citation analysis; Heart failure; Science mapping
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13509
  22. Hum Vaccin Immunother. 2023 Feb 20. 2173905
    Global trends in poliomyelitis research over the past 20 years: A bibliometric analysis.
    Qi Liu, Ze Liu, Biling Huang, Yuanyuan Teng, Mingliu Li, Shuqin Peng, Hongbin Guo, Min Wang, Jieyu Liang, Yi Zhang.
      Poliomyelitis is an acute infectious disease caused by poliovirus. This bibliometric analysis aims to examine the status of poliomyelitis research in the past 20 years. Information regarding polio research was obtained from the Web of Science Core Collection database. CiteSpace, VOSviewer, and Excel were used to perform visual and bibliometric analysis with respect to countries/regions, institutions, authors, journals and keywords. A total of 5,335 publications on poliomyelitis were published from 2002 to 2021. The USA was the county with the majority of publications. Additionally, the most productive institution was the Centers for Disease Control and Prevention. Sutter, RW produced the most papers and had the most co-citations. Vaccine was the journal with the most polio-related publications and citations. The most common keywords were mainly about polio immunology research ("polio," "immunization," "children," "eradication" and "vaccine"). Our study is helpful for identifying research hotspots and providing direction for future research on poliomyelitis.
    Keywords:  Poliomyelitis; Web of Science; acute flaccid myelitis; bibliometrics; vaccine
    DOI:  https://doi.org/10.1080/21645515.2023.2173905
  23. Heliyon. 2023 Feb;9(2): e13363
    Analysis of the structure of scientific knowledge on wine tourism: A bibliometric analysis.
    Bartolomé Marco-Lajara, Javier Martínez-Falcó, Luis A Millan-Tudela, Eduardo Sánchez-García.
      This research offers a bibliometric analysis of 588 publications on wine tourism published between 1998 and 2021, highlighting the years of publication, the publication format, the fields of research, the authors, the institutions, the main journals and the country of origin of both the authors and the scientific production analyzed. To our knowledge, no bibliometric study has focused on the study of wine tourism, so this study aims to fill this research gap, serving as a reference guide for both academics and professionals in the wine sector who want to know in depth how the study of this type of tourism has been approached. The results of the research show that the academic study of wine tourism dates back to the end of the 1990s, with the New World countries standing out in its study, especially Australia as the country with the highest scientific production and the largest number of academics focused on the study of this type of tourism. The study allows us to highlight the value of academic articles as the main means of disseminating research results, these being focused on tourism, business, economic and cross-cutting research. The results reveal relevant conclusions for academics, winemakers and tourism managers on the knowledge structure of wine tourism activity.
    Keywords:  Bibliometric analysis; Knowledge structure; Wine industry; Wine tourism
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13363
  24. Heliyon. 2023 Feb;9(2): e13280
    Sustainable brownfield redevelopment and planning: Bibliometric and visual analysis.
    Bohong Zheng, Francis Masrabaye.
      Environmental and urban sciences have shown that brownfield problems significantly impact human behavior and the environment. Understanding the sustainable planning and redevelopment of brownfields can help governments and financial partners consider sustainable urban policies a key priority. This study presents a bibliometric analysis of research publications on the sustainable redevelopment of brownfields through the Scopus database since 1990. The redevelopment of brownfields has an essential role in urban sustainability, so research trends on the sustainable redevelopment of brownfields in previous literature are revealed. To our knowledge, the bibliometric analysis of the term sustainable redevelopment of brownfields is not yet an accentuated field of research. To do this, this study aims to fill this gap by offering a broad overview of the bibliometric analysis of the literature relating to this term. Brownfield and contaminated land are used as keywords in the article titles taken from the Scopus database on September 07, 2021. A total of 7197 scientific articles (Scopus) were reviewed to show how the research on "brownfields or contaminated land" has emerged and developed. Social media analysis (VOSviewer) was used for data visualization, and Harzing's Publish or Perish used for metrics and citation analysis. The results showed an increase in the growth rate of the literature on sustainable brownfield redevelopment since 1990, particularly from 2011 to 2020. Research related to the sustainable redevelopment of brownfields has involved various authors and is published in various languages. There are 160 authors from 126 countries and 160 institutions. China is the largest contributor to this study, followed by the United States and the United Kingdom. The Chemosphere Journal has published the most articles on the sustainable redevelopment of brownfields. Although our results also indicate that studies on the sustainable redevelopment of brownfields are mainly carried out in the field of environmental sciences. Some avenues for future research have been analyzed in three directions so that sustainable development can easily be integrated into a brownfield redevelopment project.
    Keywords:  Brownfield; Contaminated land; Library analysis; Soil pollution; Sustainable development; Urban renewal
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13280
  25. Eur J Investig Health Psychol Educ. 2023 Feb 16. 13(2): 472-489
    Trends in Autism Spectrum-Related Motherhood Research: A Bibliometric Study.
    Osvaldo Hernández-González, Daniela González-Fernández, Rosario Spencer-Contreras, Raúl Tárraga-Mínguez, Viviana Ponce-Carrasco.
      Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in socialization. The amount of scientific research results on motherhood related to ASD has grown exponentially; however, there are no bibliometric studies in this field. Objective: This article aimed to analyze scientific research on motherhood related to the autism spectrum published in WoS. Articles on motherhood related to ASD were retrieved from the Web of Science (WoS). The advanced search interface used was "Title of the article, Abstract, Keywords". The analysis and visualization of the selected documents and their data were performed using a wide range of tools and software such as MS Excel (v16.0), VOS viewer (version 1.6.15), and R packages (Biblioshiny, version 2.0). A total of 1660 articles were included in this study. Most of the publications were original articles. The United States published the most significant number of articles among the countries identified. P.R. Hastings, M.M. Seltzer, and J. Van de Water were the main authors. The Journal of Autism and Developmental Disorders was the most productive and impactful journal. The main research topics were related to mental health and social support in the role of motherhood. This desk study provides researchers with a comprehensive understanding of ASD-related maternity research trends by evaluating relevant publications in recent decades. The results of this bibliometric analysis can serve as a basis and orientation for new studies.
    Keywords:  autism; bibliometrics; mothers; mother–child interaction
    DOI:  https://doi.org/10.3390/ejihpe13020036
  26. Front Public Health. 2023 ;11 1120462
    Severe fever with thrombocytopenia syndrome virus trends and hotspots in clinical research: A bibliometric analysis of global research.
    Zhengyu Zhang, Juntao Tan, Wen Jin, Hong Qian, Loulei Wang, Hu Zhou, Yuan Yuan, Xiaoxin Wu.
      Background: Since severe fever with thrombocytopenia syndrome virus (SFTSV) was first reported in 2009, a large number of relevant studies have been published. However, no bibliometrics analysis has been conducted on the literature focusing on SFTSV. This study aims to evaluate the research hotspots and future development trends of SFTSV research through bibliometric analysis, and to provide a new perspective and reference for future SFTSV research and the prevention of SFTSV.Methods: We retrieved global publications on SFTSV from the Web of Science Core Collection (WoSCC) and Scopus databases from inception of the database until 2022 using VOSviewer software and CiteSpace was used for bibliometric analysis.
    Results: The number of SFTSV-related publications has increased rapidly since 2011, peaking in 2021. A total of 45 countries/regions have published relevant publications, with China topping the list with 359. The Viruses-Basel has published the most papers on SFTSV. In addition, Yu et al. have made the greatest contribution to SFTSV research, with their published paper being the most frequently cited. The most popular SFTSV study topics included: (1) pathogenesis and symptoms, (2) characteristics of the virus and infected patients, and (3) transmission mechanism and risk factors for SFTSV.
    Conclusions: In this study, we provide a detailed description of the research developments in SFTSV since its discovery and summarize the SFTSV research trends. SFTSV research is in a phase of explosive development, and a large number of publications have been published in the past decade. There is a lack of collaboration between countries and institutions, and international collaboration and exchanges should be strengthened in the future. The current research hotpots of SFTSV is antiviral therapy, immunotherapy, virus transmission mechanism and immune response.
    Keywords:  CiteSpace; SFTSV; VOSviewer; bibliometric; data visualization
    DOI:  https://doi.org/10.3389/fpubh.2023.1120462
  27. Ann Transl Med. 2023 Jan 31. 11(2): 64
    Knowledge mapping of research on the mitochondrial unfolded protein response: a bibliometric and visual analysis.
    Ming-Xi Zhu, Si-Qi Sun, Gui-Bo Fan, A-Yang Zhao, Xing Niu, Si-Hua Qi, Yan Li.
      Background: The mitochondrial unfolded protein response (UPRmt) is a mitochondria stress response, which exerts a crucial role in maintaining mitochondrial proteostasis during stress. However, there is no bibliometric analyses systematically studied this field which could comprehensively review research trends, evaluate publication performances and provide future perspectives.Methods: Articles investigating UPRmt published between 1994 and 2021 were downloaded from the Core Collection of the Web of Science (WOS). CiteSpace and VOSviewer bibliometric software were applied for bibliometric and visual analyses.
    Results: A total of 2,073 papers researching UPRmt were retrieved. According to the published number of papers, the field of UPRmt research has gone through its infancy (after 2000) and rapid growth (after 2021) phases. The United States and China contributed the most to UPRmt research. Regarding the distribution of institutions, Harvard University was the most influential institution. The most prolific authors are Johan Auwerx and CM Haynes. PLoS One is the most extensive journal in the field of UPRmt research, while the Cell Death and Differentiation journal had the greatest impact among the most-authored journals. Moreover, biochemistry/molecular biology, and cell biology are the largest subject areas. UPRmt research is mainly categorized as UPRmt, transcription, endoplasmic reticulum (ER) stress, lipotoxicity, mitophagy, inflammation, skeletal muscle, hypoxia, apoptosis, mitochondrial dysfunction, neurodegeneration, mitochondrial permeability transition, and integrated stress response.
    Conclusions: At present, research on UPRmt is booming. Further strengthening the cooperation and exchanges between countries, institutions, and authors in the future will surely promote the development of this field.
    Keywords:  CiteSpace; Mitochondrial unfolded protein response (UPRmt); VOSviewer; Web of Science (WOS); bibliometric analysis
    DOI:  https://doi.org/10.21037/atm-22-6423
  28. Cureus. 2023 Jan;15(1): e33978
    #OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery.
    Ryan T Halvorson, Sachin Allahabadi, Nicolas Cevallos, Aidan J Foley, Kelsey Collins, Abel Torres Espin, Brian T Feeley, Nirav K Pandya, Jeannie F Bailey.
      Background #OrthoTwitter has evolved to disseminate findings and engage the public. However, the academic impact of Twitter utilization in orthopaedic surgery is unknown. Questions/purposes The purpose of the study was to evaluate relationships between the author and manuscript Twitter activity and citations. Methods Manuscripts in 17 orthopaedic journals from 2018 were identified. Citations, online mentions, impact factors, and subspecialties were obtained. H-index and Twitter account details for authors were obtained for a subset of manuscripts. Relationships between Twitter activity and citations were evaluated. Results 2,473/4,224 (58.5%) manuscripts were mentioned on Twitter (n=29,958 mentions), with Twitter manuscripts cited more frequently (median 10 vs. 7, p<0.0001). Twitter mentions, impact factors, non-open-access status, and subspecialties were associated with citation counts. Articles mentioned in 10, 100, and 1,000 Tweets were observed to have a 1.1-fold, 1.7-fold, and 245-fold increase in citations. In author-level analyses, 156 (20.0%) first and 216 (27.7%) senior authors had Twitter accounts. Citation count was associated with increasing senior author H-index (β est=0.13, p<0.05), Twitter mentions (β est=0.0043, p<0.0001), impact factors (β est=0.13, p<0.0001), and having a first (β est=0.20, p<0.05) or senior author (β est=0.17, p<0.05) on Twitter. Articles published in arthroplasty (β est=0.49, p<0.05), general interest (β est=0.55, p<0.01), sports (β est=0.63, p<0.01), and non-open access journals (β est=0.41, p<0.001) were cited more. H-index correlated with followers for first (rho=0.31, p<0.0001) and senior authors (rho=0.44, p<0.0001). Conclusion Author Twitter utilization is independently associated with manuscript citations. Authors should be aware of the potential association between social media utilization and traditional academic impact. Understanding the relationship between social media utilization and academic impact is necessary to effectively disseminate research.
    Keywords:  author-level bibliometrics; bibliometric analyis; bibliometric analyses; ortho; ortho surgery; orthopaedic research; orthopaedics; orthopaedics surgery; orthotwitter; twitter
    DOI:  https://doi.org/10.7759/cureus.33978
  29. Front Immunol. 2023 ;14 1063548
    Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis.
    Liu Bo, Liu Tianming, Fan Fengliang, Liang Wenping, Han Jinzuo, Xue Dongbo, Ma Biao, Sun Haijun.
      Background: In recent years, the vaccinia oncolytic virus has entered the clinical trial stage of examination and shown good progress. It has many advantages, such as good safety, high oncolytic efficiency, and the regulation ability of the tumor microenvironment, and is expected to be successfully used in the clinical treatment of tumors in the future. However, no bibliometric analysis has so far been performed that generalizes horizontally across this field. Therefore, this study aims to assess the research status and trends in this field from a global perspective to help guide future research priorities.Methods: In this study, the literature related to vaccinia oncolytic virus published in English on Web of Science from 2002 to 2022 was retrieved, and the bibliometric indicators were analyzed using the Histcite. Pro 2.0 tool, while VOSviewer was used to visualize the research trends and hotspots in this field.
    Results: In total, 408 related studies were included. In the past 20 years, the number of related publications in this field has increased year by year, and breakthroughs were made in this field in 2008 and 2013. The research has grown rapidly since 2008, and will likely continue to expand in the years to come. The United States plays a leading role in this area. "MOLECULAR THERAPY-ONCOLYTICS", "MOLECULAR THERAPY" and "JOURNAL OF TRANSLATIONAL MEDICINE" are core journals that publish high-quality literature on the latest advances in the field. Some authors with numerous high-quality publications include Bell JC and Szalay AA. At present, the research hotspot in this field focus on the clinical application of vaccinia oncolytic virus.
    Conclusion: Overall, the number of vaccinia oncolytic virus-related studies is growing rapidly, in relation to which the United States is the most influential country. The clinical application of vaccinia oncolytic virus will affect the crucial development of future research.
    Keywords:  VOSviewer; bibliometric; knowledge map; oncolytic virus; tumor
    DOI:  https://doi.org/10.3389/fimmu.2023.1063548
  30. Eur J Med Res. 2023 Feb 20. 28(1): 89
    Research trends and hotspots evolution of cardiac amyloidosis: a bibliometric analysis from 2000 to 2022.
    Zhenyue Fu, Jiayu Lv, Xiya Gao, Bingxuan Zhang, Yumeng Li, Xia Xu, Haoran Zheng, Huaqin Wu, Qingqiao Song.
      In the new century, cardiac amyloidosis has received more attention from many countries and institutions, leading to innovations in the essence of the pathology, biological markers, noninvasive tests, and staging diagnoses and treatments for this disease. However, few reviews have summarized the research trends and hotspots in cardiac amyloidosis. Bibliometrics analysis is a statistically based approach to research that visualizes the contributions of academic institutions and changes in research hotspots. Therefore, in this paper, we used Citespace and VOSviewer software to conduct co-occurrence analysis and collaborative network analysis on the countries, institutions, and authors in the articles related to cardiac amyloidosis since the new century. And further find out burst keywords and references to obtain the research history, disciplinary development, and new hotspots and topics.
    Keywords:  AL amyloidosis; Bibliometric analysis; Cardiac amyloidosis; Heart failure; Transthyretin amyloidosis
    DOI:  https://doi.org/10.1186/s40001-023-01026-5
  31. Eur J Investig Health Psychol Educ. 2023 Jan 20. 13(2): 228-237
    Female Dynamics in Authorship of Scientific Publications in the Public Library of Science: A 10-year Bibliometric Analysis of Biomedical Research.
    Panagiotis Giannos, Konstantinos Katsikas Triantafyllidis, Maria Paraskevaidi, Maria Kyrgiou, Konstantinos S Kechagias.
      Women are generally underrepresented in science, technology, engineering, and mathematics (STEM). As scientific production reflects scholarly impact and participation in the scientific process, the number of journal publications forms a pertinent measure of academic productivity. This study examined the prevalence and evolution of female representation in prominent author positions across multidisciplinary biomedical research. Publications from seven exemplar cross-specialty journals of the Public Library of Science (PLoS Medicine, PLoS Biology, PLoS One, PLoS Computational Biology, PLoS Genetics, PLoS Pathogens, and PLoS Neglected Tropical Diseases) between January 2010 and December 2020 were extracted from Web of Science. Using Genderize.io, the gender of authors from their first names was estimated using a 75% threshold. The association between female prevalence in first and last authorship and journal was evaluated using a binary logistic regression, and odds ratios were estimated against a 50:50 reference on gender. In 266,739 publications, 43.3% of first authors and 26.7% of last authors were females. Across the ten-year period, female first authorship increased by 19.6% and last authorship by 3.2%. Among all journals, PLoS Neglected Tropical Diseases had the greatest total proportion of female first authors (45.7%) and PLoS Medicine of female last authors (32%), while PLoS Computational Biology had the lowest proportion in these categories (23.7% and 17.2%). First authors were less likely to be females in all PLoS journals (p < 0.05) except for PLoS Neglected Tropical Diseases (odds ratio: 0.84, 95% confidence interval: 0.71-1.00), where the odds of female authorship were not significantly different (p = 0.054). Last authors were not more likely to be females in all PLoS journals (p < 0.001). Overall, women still appear underrepresented as first authors in biomedical publications and their representation as last authors has severely lagged. Efforts towards gender equality in scholarly authorship will contribute to the representation of women in biomedical research and ensure that their potential is not lost.
    Keywords:  PLoS; diversity; equality; gender; research
    DOI:  https://doi.org/10.3390/ejihpe13020018
  32. Medicine (Baltimore). 2023 Feb 22. 102(8): e32955
    Analysis of citation trends to identify articles on delirium worth reading using DDPP model with temporal heatmaps (THM): A bibliometric analysis.
    Sam Yu-Chieh Ho, Tsair-Wei Chien, Kang-Ting Tsai, Willy Chou.
      BACKGROUND: Delirium is one of the most common geriatric syndromes in older patients, accounting for 25% of hospitalized older patients, 31 to 35% of patients in the intensive care unit, and 8% to 17% of older patients in the emergency department (ED). A number of articles have been published in the literature regarding delirium. However, it is unclear about article citations evolving in the field. This study proposed a temporal heatmap (THM) that can be applied to all bibliographical studies for a better understanding of cited articles worth reading.METHODS: As of November 25, 2022, 11,668 abstracts published on delirium since 2013 were retrieved from the Web of Science core collection. Research achievements were measured using the CJAL score. Social network analysis was applied to examine clusters of keywords associated with core concepts of research. A THM was proposed to detect articles worth reading based on recent citations that are increasing. The 100 top-cited articles related to delirium were displayed on an impact beam plot (IBP).
    RESULTS: The results indicate that the US (12474), Vanderbilt University (US) (634), Anesthesiology (2168), and Alessandro Morandi (Italy) (116) had the highest CJAL scores in countries, institutes, departments, and authors, respectively. Articles worthy of reading were highlighted on a THM and an IBP when an increasing trend of citations over the last 4 years was observed.
    CONCLUSION: The THM and IBP were proposed to highlight articles worth reading, and we recommend that more future bibliographical studies utilize the 2 visualizations and not restrict them solely to delirium-related articles in the future.
    DOI:  https://doi.org/10.1097/MD.0000000000032955
  33. J Bioenerg Biomembr. 2023 Feb;55(1): 43-57
    The status and trends of mitochondrial dynamics research: A global bibliometric and visualized analysis.
    Zijian Guo, Zehua Wang, Zhenzhong Gao, Tengda Feng, Yingjie Gao, Zhiwen Yin, Zui Tian, Yang Liu, Xingjia Mao, Chuan Xiang.
      BACKGROUND: Mitochondria are remarkably dynamic organelles encapsulated by bilayer membranes. The dynamic properties of mitochondria are critical for energy production.AIMS: The aim of our study is to investigate the global status and trends of mitochondrial dynamics research and predict popular topics and directions in the field.
    METHODS: Publications related to the studies of mitochondrial dynamics from 2002 to 2021 were retrieved from Web of Science database. A total of 4,576 publications were included. Bibliometric analysis was conducted by visualization of similarities viewer and GraphPadPrism 5 software.
    RESULTS: There is an increasing trend of mitochondrial dynamics research during the last 20 years. The cumulative number of publications about mitochondrial dynamics research followed the logistic growth model [Formula: see text]. The USA made the highest contributions to the global research. The journal Biochimica et Biophysica Acta (BBA)-Molecular Cell Research had the largest publication numbers. Case Western Reserve University is the most contributive institution. The main research orientation and funding agency were cell biology and HHS. All keywords related studies could be divided into three clusters: "Related disease research", "Mechanism research" and "Cell metabolism research".
    CONCLUSIONS: Attention should be drawn to the latest popular research and more efforts will be put into mechanistic research, which may inspire new clinical treatments for the associated diseases.
    Keywords:  Bibliometrics; Mitochondrial dynamics; Visualized analysis
    DOI:  https://doi.org/10.1007/s10863-023-09959-6
  34. Front Oncol. 2023 ;13 1115852
    The research landscape of the quality of life or psychological impact on gynecological cancer patients: A bibliometric analysis.
    Jiayuan Zhao, Yujia Kong, Yang Xiang, Junjun Yang.
      Background: Gynecological cancer is one of the most common cancers in women. The quality of life (QoL) or psychological impact has emerged as an outcome indicator in many clinical trials of gynecological cancer and gained much concern in the clinical setting at the start of the 21st century. Our paper conducted a bibliometric analysis of QoL or psychological impact on gynecological cancer patients to show the status and hotspots.Methods: Related publications from 2000 to 2022 were included by screening from the Web of Science Core Collection (WOSCC) on 26 June 2022. The bibliometrics was analyzed and visualized by bibliometrix R-package, VOSviewer, and CiteSpace V.
    Results: A total of 6,479 publications were included in our study. The publications in this field were increased annually. The United States (n = 2,075) was the country with the most published papers. Sydney University (n = 167) was the most productive affiliation. Gynecologic Oncology and Journal of Clinical Oncology were the most relevant and most cited sources, respectively. The article written by Bray F et al. has the highest citation. Kim J and Aaronson NK ranked first in most productive author and most co-cited author, respectively. The keywords "mortality", "fertility preservation", and "palliative care" have bursts till 2022, which represented the frontiers of this field.
    Conclusion: Our study provides an overall analysis of QoL or psychological impact on gynecological cancer patients, which can serve as a reference in future research.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; female; genital neoplasms; psychologic; quality of life
    DOI:  https://doi.org/10.3389/fonc.2023.1115852
  35. Front Aging Neurosci. 2023 ;15 1078807
    A bibliometric analysis of the application of imaging in sleep in neurodegenerative disease.
    Mengfei Li, Zhenzhen Jiang, Ru Wen, Chen Liu, Jian Wang.
      Objective: The purpose of this study was to examine the current state of the application of imaging in sleep research in degenerative disease, as well as hotspots and trends.Materials and methods: A search was conducted on the Web of Science Core Collection (WoSCC) between 1 September 2012, and 31 August 2022 for literature related to sleep imaging. This study analyzed 7,679 articles published in this field over the past 10 years, using CiteSpace to analyze tendencies, countries, institutions, authors, and hotspots.
    Results: There were 7,679 articles on the application of imaging to sleep research published by 566 institutions located in 135 countries in 1,428 journals; the number of articles was increasing on a yearly basis. According to keyword analysis, the research direction of the application of imaging in sleep research focused on the effects of degenerative diseases on sleep, such as Parkinson's disease, Alzheimer's disease, and small vessel disease. A literature evaluation found that Parkinson's disease, insomnia, sleep quality, and rapid eye movement sleep behavior disorder were the top research trends in this field.
    Conclusion: A growing body of research has focused on sleep disorders caused by degenerative diseases. In the application of imaging to sleep research, magnetic resonance functional brain imaging represents a reliable research method. In the future, more aging-related diseases may be the subject of sleep-related research, and imaging could provide convenient and reliable evidence in this respect.
    Keywords:  CiteSpace; bibliometrics; degenerative disease; imaging; sleep
    DOI:  https://doi.org/10.3389/fnagi.2023.1078807
  36. Med Sci Monit. 2023 Feb 20. 29 e938673
    Drug-Induced Cardiotoxicity in Children During the Past 30 Years: A Bibliometric Study and Visualization Analysis.
    Mingfen Wu, Yang Yang, Mingnan Cao, Teng Liu, Yue Tian, Zhigang Zhao, Bin Zhu.
      BACKGROUND Drug-induced cardiotoxicity (DICT) is one of the most serious adverse drug reactions, which is an important safety issue in drug development and clinical practice. This study aimed to summarize the knowledge structure and to detect emerging trends, and provide ideas for future research on DICT in children using bibliometric methods. MATERIAL AND METHODS All publications on DICT in children were retrieved through the Web of Science Core Collection up to April 20, 2022. The document type was restricted to articles with the language set to English. CiteSpace and VOSviewer were used to conduct this bibliometric analysis. RESULTS A total of 298 articles were included, and the annual publications decreased since 2021. The United States was the leading country with the most publications (117), the highest centrality (0.39), and total citations (4055). The most influential institution was the University of British Columbia, while Carleton BC and Rassekh SR, both from Canada, were the most productive authors, but there was no leader in this field. The keywords with both high frequency and high centrality after excluding "cardiotoxicity" and "children" were acute lymphoblastic leukemia (Freq=43, Central=0.15), childhood cancer (Freq=42, Central=0.13), toxicity (Freq=33, Central=0.16), and breast cancer (Freq=29, Central=0.19). "Adriamycin cardiotoxicity" was the first burst keyword, while "childhood cancer", "oxidative stress", and "cardiac dysfunction" were emerging research hotspots. CONCLUSIONS Attention to DICT in children was insufficient. This study serves as a breakthrough point, providing a comprehensive overview of the knowledge structure, development landscape, and future opportunities in this field.
    DOI:  https://doi.org/10.12659/MSM.938673
  37. Arab J Urol. 2023 ;21(1): 1-9
    The status of bladder cancer research worldwide, a bibliometric review and recommendations.
    Hussein Awada, Adel Hajj Ali, Mohammad A Zeineddine, Hasan Nassereldine, Zahy Abdul Sater, Deborah Mukherji.
      Background: Healthcare system costs associated with bladder cancer treatment are among the highest of curable malignancies, and prognosis in advanced disease remains poor. This scoping review examines the worldwide status of bladder cancer research by systematically mapping publications, exploring research topics, support, gaps and limitations that need to be addressed.Methods: We searched the Web of Science database for publications using controlled vocabulary. Results were limited between 2000-2020, and were included in our study based on pre-specified eligibility criteria. Data used for analysis included author's names, country of affiliation, language, journal, citations, and funding. Analysis was conducted using Biblioshiny R and SPSS. Research topics were identified according to sub-filters of title words and strings pre-determined by authors.
    Results: 40,657 results were retrieved, of which 19,976 original articles and reviews met the pre-specified criteria. 92% of the publications originated from 20 countries and were included in the analysis. Trends show an increase across the world, most of which is due to increasing contributions from USA and China. An increase by 1000% in funded publications has been achieved. Studies focused on Surgery, Pathology, and Diagnosis, while Radiotherapy, Palliative care, quality of life and Epidemiology were the least described. Genetics had the most increase while being the most funded. GDP, incidence, prevalence and mortality were each significantly positively correlated with overall bladder cancer research output.
    Conclusion: This review described the evolution of bladder cancer research. It also identified significant gaps and limitations that need to be highlighted as priority areas for research investment.
    Keywords:  Bladder Cancer; bibliometric review; oncology; research; urology; urothelial carcinoma
    DOI:  https://doi.org/10.1080/2090598X.2022.2152237
  38. Front Neurosci. 2023 ;17 1105158
    A bibliometric analysis of apoptosis in glaucoma.
    Jia-Heng Zhang, Mei-Juan Wang, Ya-Ting Tan, Jia Luo, Shu-Chao Wang.
      Background: Glaucoma is the first irreversible and second blindness disease, which is characterized by the death of retinal ganglion cells (RGCs) and degeneration of the optic nerve. Previous works have indicated that apoptosis is the main reason for RGC death in glaucoma. Although many studies have investigated the mechanism of apoptosis and different strategies targeting apoptosis to protect the RGCs and finally recover the impaired vision in the glaucoma. However, the global trend and hotspots of apoptosis in glaucoma have not been well illustrated and discussed.Methods: Documents were extracted from the Web of Science Core Collection on November 2, 2022. We selected articles and reviews published in English from January 1, 1999 to November 1, 2022 to perform visual analysis and statistical analysis of countries, institutions, authors, references and keywords by VOSviewer 1.6.18 and CiteSpace 5.8.
    Results: The publications about apoptosis in glaucoma show an increasing trend over time. Besides, the authors, institutions in the US and China published the most numbers of articles with the highest citation, which may be leading the research in the field of apoptosis in glaucoma. Last, series of advanced research results, technology and treatment for glaucoma, such as the discovery of key regulatory mechanisms on RGC apoptosis are emerging and will provide precise strategies for the treatment of glaucoma.
    Conclusion: This research will broaden our comprehension about the role of apoptosis in the process of glaucoma, and provide guidelines for us in basic research and disease treatment in the further.
    Keywords:  CiteSpace; VOSviewer; apoptosis; bibliometric; glaucoma; retinal ganglion cell
    DOI:  https://doi.org/10.3389/fnins.2023.1105158
  39. Front Oncol. 2023 ;13 1077539
    A bibliometric and visual analysis of publications on artificial intelligence in colorectal cancer (2002-2022).
    Pan Huang, Zongfeng Feng, Xufeng Shu, Ahao Wu, Zhonghao Wang, Tengcheng Hu, Yi Cao, Yi Tu, Zhengrong Li.
      Background: Colorectal cancer (CRC) has the third-highest incidence and second-highest mortality rate of all cancers worldwide. Early diagnosis and screening of CRC have been the focus of research in this field. With the continuous development of artificial intelligence (AI) technology, AI has advantages in many aspects of CRC, such as adenoma screening, genetic testing, and prediction of tumor metastasis.Objective: This study uses bibliometrics to analyze research in AI in CRC, summarize the field's history and current status of research, and predict future research directions.
    Method: We searched the SCIE database for all literature on CRC and AI. The documents span the period 2002-2022. we used bibliometrics to analyze the data of these papers, such as authors, countries, institutions, and references. Co-authorship, co-citation, and co-occurrence analysis were the main methods of analysis. Citespace, VOSviewer, and SCImago Graphica were used to visualize the results.
    Result: This study selected 1,531 articles on AI in CRC. China has published a maximum number of 580 such articles in this field. The U.S. had the most quality publications, boasting an average citation per article of 46.13. Mori Y and Ding K were the two authors with the highest number of articles. Scientific Reports, Cancers, and Frontiers in Oncology are this field's most widely published journals. Institutions from China occupy the top 9 positions among the most published institutions. We found that research on AI in this field mainly focuses on colonoscopy-assisted diagnosis, imaging histology, and pathology examination.
    Conclusion: AI in CRC is currently in the development stage with good prospects. AI is currently widely used in colonoscopy, imageomics, and pathology. However, the scope of AI applications is still limited, and there is a lack of inter-institutional collaboration. The pervasiveness of AI technology is the main direction of future housing development in this field.
    Keywords:  CiteSpace; VOSviewer; artificial intelligence; bibliometrics; colorectal cancer; deep learning; visualization
    DOI:  https://doi.org/10.3389/fonc.2023.1077539
  40. J Educ Health Promot. 2022 ;11 418
    Four decades of hand microsurgery in Iran: A bibliographic analysis.
    Hooman Shariatzadeh, Mohsen Motalebi, Farhad Soltani, Farid Najd Mazhar, Ali Behmanesh, Meysam Fathi, Mohsen Barkam, Seyed Jafar Ehsanzadeh, Roshanak Shams.
      BACKGROUND: The aim of this study was to perform a bibliometric analysis to assess the number of articles published by Iranian researchers in the field of hand and microsurgery over the last four decades.MATERIALS AND METHODS: An online search was conducted using 685 keywords in the abstract/title sections of articles, including carpal tunnel syndrome, wrist fractures, nerve injury and repair, skin flap and graft in the hand, congenital disorders in the hand and forearm, tumor in the hand and wrist, and infection in the hand and wrist. From February 1976 to May 2021, EndNote software version 8.1 was used to search articles in PubMed and Scopus databases. Articles in which at least one of the authors was affiliated with Iran were chosen. The name of the original institution, field of study, total number of publications, type of study, collaboration rate of Iranian hand surgeons for each year, and annual sharing of Iranian articles in journals with the highest cite scores in the field of hand and microsurgery were all examined in the present study.
    RESULTS: The total number of publications in the field of hand and microsurgery was 632 (an average of 11 papers per year). Most of the Iranian hand and microsurgery papers were from the capital city, Tehran (38.09%). There was an increasing trend in the number of publications over the years, most which were about carpal tunnel syndrome (21.5%), tendon (9.8%), and nerve (9.6%). In total, 59.6% were descriptive articles, whereas the proportion of clinical trials was relatively small (22.3%).
    CONCLUSIONS: Iranian hand microsurgeons have continued to increase their scientific output in hand microsurgery and related fields over the last 40 years. The quality of Iranian hand microsurgeons' scientific output, both within and outside their discipline, has greatly improved; however, they still have a long way to go before becoming a hub of science.
    LEVEL OF EVIDENCE: IV, retrospective study without control group.
    Keywords:  Bibliographic analysis; carpal tunnel syndrome; hand surgery; microsurgery
    DOI:  https://doi.org/10.4103/jehp.jehp_134_22
  41. Medicine (Baltimore). 2023 Feb 22. 102(8): e32989
    Visual analysis of image-guided radiation therapy based on bibliometrics: A review.
    Jin-Hui Yuan, Qing-Song Li, Yan Shen.
      Radiation therapy plays an important role in tumor treatment. The development of image-guided radiation therapy (IGRT) technology provides a strong guarantee for precise radiation therapy of tumors. However, bibliometric studies on IGRT research have rarely been reported. This study uses literature collected from the Web of Science during 1987 to 2021 as a sample and uses the bibliometric method to reveal the current research status, hotspots, and development trends in IGRT. Based on 6407 papers published from the Web of Science during 1987 to 2021, we utilized Microsoft Excel 2007 and cite space software to perform statistical analysis and visualization of IGRT. A total of 6407 articles were included, this area of IGRT has gone through 4 stages: budding period, growth period, outbreak period, and stationary period. The research category is mainly distributed in Radiology Nuclear Medicine Medical Imaging, which intersects with the research categories of Materials, Physics, and Mathematics. Yin FF, Tanderup K, and Sonke JJ are highly productive scholars who are active in IGRT research, while Jaffray DA, van Herk M and Guckenberger M are authors with high impact in this field. The team of scholars has close cooperation within the team and weak cooperation among teams. The League of European Research Universities, University of Texas System, University of Toronto, and Princess Margaret Cancer are the main research institutions in this field. The United States has the most research literature, followed by China and Germany. Six thousand four hundred seven articles are distributed in 712 journals, and the top 3 journals are Med Phys, Int J Radiat Oncol, and Radiather Oncol. Precise registration, intelligence, magnetic resonance guidance, and deep learning are current research hotspots. These results demonstrate that the research in this field is relatively mature and fruitful in the past 35 years, providing a solid theoretical basis and practical experience for precision radiotherapy.
    DOI:  https://doi.org/10.1097/MD.0000000000032989
  42. Front Physiol. 2023 ;14 1110399
    A bibliometric review of 35 years of studies about preeclampsia.
    Razieh Akbari, Sedigheh Hantoushzadeh, Zahra Panahi, Sajedeh Bahonar, Marjan Ghaemi.
      The purpose of this study is to investigate preeclampsia. It used the visualization tools of CiteSpace, VOSviewer, Gunnmap, Bibliometrix®, and Carrot2 to analyze 3,754 preeclampsia studies from 1985 to 2020 in Obstetrics and Gynecology areas. Carrot2 was used to explain each cluster in extra detail. The results found that there is an increasing trend in many publications related to preeclampsia from 1985 to 2020. The number of studies on preeclampsia has increased significantly in the last century. Analysis of the keywords found a strong relationship with preeclampsia concepts and keywords classified into five categories. Co-citation analysis was also performed which was classified into six categories. Reading the article offers important to support not only to grind the context of preeclampsia challenges but also to design a new trend in this field. The number of studies on preeclampsia has substantially improved over the decades ago. The findings of documents published from 1985 to 2020 showed three stages in research on this subject: 1985 to 1997 (a seeding stage), 1997-2005 (rapid growth stage), and 2005 onwards (development stage).
    Keywords:  bibliometric; co-citation; co-occurrence, theme evolution; preeclampsia; web of science database
    DOI:  https://doi.org/10.3389/fphys.2023.1110399
  43. Eur Radiol. 2023 Feb 23.
    Who publishes imaging articles in non-imaging journals? A large sample data-mining study.
    Augustin Gaudemer, Adrien Haegel, Marco Dioguardi Burgio, Valérie Vilgrain, Jules Grégory, Maxime Ronot.
      OBJECTIVES: To assess the weight of imaging and imaging specialists (i.e., affiliated to a radiology/nuclear medicine department) in publications in non-imaging journals.METHODS: All articles indexed in English on the Embase database between 1989 and 2019 were extracted. The number and affiliation of authors were determined. A naive Bayesian classifier algorithm was trained to classify abstracts as "imaging" or "non-imaging." The main outcome was the number and position of imaging specialists in the authorship of imaging articles published in non-imaging journals. Analyses per medical specialties and per journal impact factor (IF) were performed.
    RESULTS: A total of 15,787,825 articles were included with 968,259 (6%) "imaging" articles. The proportion of imaging articles increased over time (+ 370%), quicker than the overall academic output. The proportion of imaging specialist among authors grew from 0.58% in 1989-1994 to 1.54% in 2015-2019. About 20% of imaging articles had ≥ 1 imaging specialist among authors. The proportion of imaging articles decreased with the IF (7.3% for IF 0-2.5 vs. 5.1% for IF > 10, p < 0.001), but the proportion of imaging specialist authors in imaging papers with ≥ 1 imaging specialist author increased with the IF (40% for IF 0-2.5, 53% for IF > 10, p < 0.001). There was significant variability across medical specialties.
    CONCLUSIONS: The weight of imaging articles and imaging specialist among authors in non-imaging journals has increased over time but remains limited. Most of the authors of imaging publications are not imaging specialists. Imaging specialists among authors in imaging papers are associated with a greater IF.
    KEY POINTS: • The proportion of imaging specialist authors in non-imaging journals, though small, has increased significantly. • Marked differences are observed according to medical specialties and the reputation/impact factor of the journal. • Collaboration between imaging specialists and non-specialists is associated with publication in higher impact journals.
    Keywords:  Bibliometrics; Data mining; Diagnostic imaging; Nuclear medicine
    DOI:  https://doi.org/10.1007/s00330-023-09495-2
  44. J Clin Epidemiol. 2023 Feb 21. pii: S0895-4356(23)00012-4. [Epub ahead of print]
    A cross-sectional analysis identified co-authorship networks and scientific collaboration on reporting guidelines for health research.
    Ferrán Catalá-López, Adolfo Alonso-Arroyo, Matthew J Page, Lourdes Castelló-Cogollos, Brian Hutton, Manuel Ridao, Rafael Tabarés-Seisdedos, Rafael Aleixandre-Benavent, David Moher.
      OBJECTIVE: To investigate scientific collaboration and citation metrics of reporting guidelines for health research.STUDY DESIGN AND SETTING: Cross-sectional analysis of published articles for reporting guidelines for health research. A search of the EQUATOR (Enhancing the QUAlity and Transparency Of health Research) Network Library (from inception to January 21, 2021) was supplemented by searching websites of guideline developers. For each article, metadata (e.g., authors, institutions, countries, citations) were extracted from the Web of Science and Scopus (up to October 25, 2021). Descriptive analyses were conducted. Network analyses of collaborations were presented.
    RESULTS: We included 662 articles published in 332 journals. The BMJ (n=50 articles; 8%), Annals of Internal Medicine (n=29; 4%), and Journal of Clinical Epidemiology (n=24; 4%) published the largest number of articles. 4722 authors, 1647 institutions, and 83 countries were involved. The global productivity was led by the United States (n=456 articles), the United Kingdom (n=414), and Canada (n=306). We found 8 clusters of authors (e.g., one major group with 337 members) and 3 clusters of institutions (e.g., one major group with 256 members). The most prolific authors were affiliated with the Ottawa Hospital Research Institute (Canada), the University of Ottawa (Canada), the University of Oxford (United Kingdom), and Stanford University (United States).
    CONCLUSION: Our analysis identified key actors producing reporting guidelines, most intense collaborations, and 'citation classics' in the field. These results could potentially be used to strengthen collaborations for developing and disseminating reporting guidelines for health research.
    Keywords:  Bibliometrics; EQUATOR Network; Reporting guidelines; Scientific collaboration
    DOI:  https://doi.org/10.1016/j.jclinepi.2023.02.001
  45. J Nephrol. 2023 Feb 22.
    Evaluation of gender trends in first authorship in nephrology publications in four major US journals in the last decade.
    Rahul Regi Abraham, Oluwadamilola Adisa, Myra Ellen Owen, Fatima Iqbal, Karina Sulaiman.
      BACKGROUND: To date, no data exist on gender-related publication biases in nephrology. This study was conducted to determine whether gender differences exist in the current literature published in high-ranking US nephrology journals, and how they may have changed over time.METHODS: The PubMed search was performed using the easyPubMed package in R, which extracted all articles indexed in PubMed from 2011 to 2021 from the US nephrology journals with the highest impact factors, i.e., Journal of the American Society of Nephrology (JASN), American Journal of Nephrology (AJN), American Journal of Kidney diseases (AJKD), and the Clinical Journal of the American Society of Nephrology (CJASN). Gender with predictions > 90% were accepted and the remaining were manually identified. Descriptive statistical analysis was carried out on the data.
    RESULTS: We identified 11,608 articles. On average, the ratio of male to female first authors decreased from 1.9 to 1.5 (p < 0.05). Additionally, in 2011, women accounted for 32% of first authors, a number that rose to 40% in 2021. All but the American Journal of Nephrology showed a variation in the ratio of men to women first authors. For the JASN, the ratio changed from 1.81 to 1.58, p = 0.001, for CJASN, the ratio declined from 1.91 to 1.15, p = 0.005 and for AJKD, the ratio declined from 2.19 to 1.19, p = 0.002.
    DISCUSSION AND CONCLUSIONS: Our study shows that gender biases in publications continue to exist in first-author publications in high-ranking Nephrology journals published in the US; the gap is however closing. We hope this study lays the groundwork to continue following and evaluating gender trends in publication.
    Keywords:  Gender biases; Gender trends; Nephrology publication
    DOI:  https://doi.org/10.1007/s40620-022-01557-w
  46. Antioxidants (Basel). 2023 Jan 31. pii: 330. [Epub ahead of print]12(2):
    Dental Caries and Salivary Oxidative Stress: Global Scientific Research Landscape.
    Yago Gecy de Sousa Né, Weslley Ferreira Lima, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Leonardo Oliveira Bittencourt, Priscila Cunha Nascimento, Renata Duarte de Souza-Rodrigues, Luiz Renato Paranhos, Paulo Antônio Martins-Júnior, Rafael Rodrigues Lima.
      This study aimed to analyze the research trends on salivary oxidative stress associated with dental caries and to perform bibliometric approaches for existing publications on this association. A search was performed using the Web of Science Core Collection, without any restriction of language or publication year. The number of periodicals with the most published articles in this theme, most published authors and keywords were mapped; other metrics were also evaluated such as the countries that have more research on the subject and the period in which there were more publications on the subject. During the knowledge mapping, the most frequent experimental designs were analyzed, type of saliva collection, stage of caries disease, evaluated oxidative parameters were retrieved and analyzed from each manuscript. Between the 43 selected articles, the Journal of Clinical Pediatric Dentistry was the periodical appearing the most with 4 published articles. The authors who published the most were Celec, P., Tothova, L., Hegde, A.M., Shetty, S., Antoniali, C., and Pessan, JP with three articles each, and a total of 180 keywords representing the evolution of the theme. India and Asia were found to be the country and continent with most publications, respectively. Most articles collected non-stimulated total saliva, with total antioxidant capacity being the parameter most often evaluated. The type of study that appeared the most was cross-sectional studies, and articles published in the period of 2017-2022 were the most frequent. Studies show that dental caries can be associated to the changes in salivary oxidative biochemistry with an increase in lipid peroxidation, a biomarker of oxidative damage, and an increase in antioxidant capacity in chronic caries, in response to cariogenic challenge. Some studies evidence the reduction of lipid peroxidation after treatment of the carious lesion. Our findings reveal worldwide research trends, as well as a clearer knowledge of the evolution and future scenarios of this issue, also showing the mechanisms associating dental caries with changes in salivary oxidative biochemical parameters are not clear.
    Keywords:  dental caries; oxidative stress; saliva
    DOI:  https://doi.org/10.3390/antiox12020330
  47. J Funct Morphol Kinesiol. 2023 Jan 30. pii: 18. [Epub ahead of print]8(1):
    The Issue of Gender Bias Represented in Authorship in the Fields of Exercise and Rehabilitation: A 5-Year Research in Indexed Journals.
    Natascia Rinaldo, Giovanni Piva, Suzanne Ryder, Anna Crepaldi, Alba Pasini, Lorenzo Caruso, Roberto Manfredini, Sofia Straudi, Fabio Manfredini, Nicola Lamberti.
      Despite progress made in recent decades, gender bias is still present in scientific publication authorship. The underrepresentation of women and overrepresentation of men has already been reported in the medical fields but little is known in the fields of exercise sciences and rehabilitation. This study examines trends in authorship by gender in this field in the last 5 years. All randomized controlled trials published in indexed journals from April 2017 to March 2022 through the widely inclusive Medline dataset using the MeSH term "exercise therapy" were collected, and the gender of the first and last authors was identified through names, pronouns and photographs. Year of publication, country of affiliation of the first author, and ranking of the journal were also collected. A chi-squared test for trends and logistic regression models were performed to analyze the odds of a woman being a first or last author. The analysis was performed on a total of 5259 articles. Overall, 47% had a woman as the first author and 33% had a woman as the last author, with a similar trend over five years. The trend in women's authorship varied by geographical area, with the higher representation of women authors in Oceania (first: 53.1%; last: 38.8%), North-Central America (first: 45.3%; last: 37.2%), and Europe (first: 47.2%; last: 33.3%). The logistic regression models (p < 0.001) indicated that women have lower odds of being authors in prominent authorship positions in higher-ranked journals. In conclusion, over the last five years, in the field of exercise and rehabilitation research, women and men are almost equally represented as first authors, in contrast with other medical areas. However, gender bias, unfavoring women, still exists, especially in the last authorship position, regardless of geographical area and journal ranking.
    Keywords:  authorship position; exercise; exercise therapy; gender; gender bias; journal ranking; rehabilitation
    DOI:  https://doi.org/10.3390/jfmk8010018
  48. Environ Sci Pollut Res Int. 2023 Feb 21.
    Nine decades of data on environmental chemical pollutant exposure in dogs: a bibliometric analysis.
    Albert Avila, Laura Prieto, Andrea Luna-Acosta.
      In recent decades, a global concern associated with environmental chemical contamination has emerged as an important risk factor for the development of human diseases. Risk assessment methods based on animal approaches have shown to be very useful as early warning systems. However, questions, knowledge gaps, and limitations still need to be addressed in animals close to humans, such as dogs. The objective of this study was to analyze citation patterns, impact of publications, and most relevant authors, countries, institutional affiliations, and lines of research on environmental chemical contaminants and their relationship with dogs, in terms of exposure and biological effects. For this, a bibliometric analysis was carried out. Results revealed an increase in scientific production on this subject during the last 90 years in journals such as Health Physics, Science of the Total Environment, and Plos One, highlighting authors such as Muggenburg, Sonne, Boecker, and Dietz. The USA, Brazil, Germany, and the UK and universities such as California, Colorado State, and Purdue were the most relevant countries and institutional affiliations in scientific production and collaboration in relation to this topic. There is a growing interest in the development of lines of research related to heavy metals (mercury and lead mainly) and persistent organic compounds (PCBs, PBDEs, pesticides) using dogs as sentinels, as well as new sources of interest related to zoonosis and One Health. Finally, issues related to pollutants, sentinel lymph nodes, and epidemiology appear as new areas of research. These results highlight interesting current challenges and future research perspectives on dogs as sentinels for environmental chemical contamination.
    Keywords:  Bibliometric; Dogs; Effects; Environmental chemical pollutants; Exposure; Sentinel
    DOI:  https://doi.org/10.1007/s11356-022-24791-y
  49. Front Oncol. 2023 ;13 1064815
    Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis.
    Xin Wu, Shiwei Ma, Zhongguang Wu, Qiangqiang Zhao.
      Objective: This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to the role of Metalloproteinase in osteosarcoma.Methods: 945 Articles and reviews associated with the role of Metalloproteinase in osteosarcoma were obtained from the WoSCC and analyzed by Citespace and Vosviewer.
    Results: The main aspects of research on the role of MMP in OS are invasion and metastasis. The latest hotspots were found to be the mechanism of MMP promoting invasion and metastasis, lung metastasis, and antitumor activity. Notably, invasion, metastasis, and antitumor activity were potentially turning points in the MMP-OS field. In the future, the primary research hotspot in the field of MMP-OS may be to study the mechanism, explore their role in the OS lung metastasis, and determine their role in the cancer therapy process.
    Conclusion: This study thus offers a comprehensive overview of the MMP-OS-related field using bibliometrics and visual methods, which will provide a valuable reference for researchers interested in the field of MMP-OS.
    Keywords:  bibliometric; matrix metalloproteinase; osteosarcoma; prognoses; pulmonary metastasis
    DOI:  https://doi.org/10.3389/fonc.2023.1064815
  50. Front Public Health. 2023 ;11 1044426
    Knowledge domain and emerging trends in HIV-MTB co-infection from 2017 to 2022: A scientometric analysis based on VOSviewer and CiteSpace.
    Miaona Liu, Wei Li, Wenmei Qiao, Limian Liang, Zhaoqin Wang.
      Co-infection with Mycobacterium tuberculosis (MTB) in human immunodeficiency virus (HIV)-infected individuals is one of the leading causes of death. Also, research on HIV and MTB (HIV-MTB) co-infection was found to have a downward trend. In this work, we performed the knowledge domain analysis and visualized the current research progress and emerging trends in HIV-MTB co-infection between 2017 and 2022 by using VOSviewer and CiteSpace. The relevant literatures in this article were collected in the Web of Science (WoS) database. VOSviewer and CiteSpace bibliometric software were applied to perform the analysis and visualization of scientific productivity and frontier. Among all the countries, USA was dominant in the field, followed by South Africa, and England. Among all the institutions, the University of Cape Town (South Africa) had more extensive collaborations with other research institutions. The Int J Tuberc Lung Dis was regarded as the foremost productive journal. Survival and mortality analysis, pathogenesis, epidemiological studies, diagnostic methods, prognosis improvement of quality of life, clinical studies and multiple infections (especially co-infection with COVID-19) resulted in the knowledge bases for HIV-MTB co-infection. The clinical research on HIV-MTB co-infection has gradually shifted from randomized controlled trials to open-label trials, while the cognition of HIV-TB has gradually shifted from cytokines to genetic polymorphisms. This scientometric study used quantitative and qualitative methods to conduct a comprehensive review of research on HIV-MTB co-infection published over the past 5 years, providing some useful references to further the study of HIV-MTB co-infection.
    Keywords:  CiteSpace; Mycobacterium tuberculosis (MTB); VOSviewer; human immunodeficiency virus (HIV); infectious disease; scientometric analysis
    DOI:  https://doi.org/10.3389/fpubh.2023.1044426
  51. Support Care Cancer. 2023 Feb 22. 31(3): 179
    Mapping the global research landscape on nutritional support for patients with gastrointestinal malignancy: visualization analysis.
    Muna Shakhshir, Amani S Abushanab, Amer Koni, Abdelkarim Barqawi, Khaled Demyati, Samah W Al-Jabi, Sa'ed H Zyoud.
      BACKGROUND: Early nutritional treatment is crucial for the care of patients with operable and advanced gastrointestinal malignancies. Therefore, much research has focused on nutritional support for patients with gastrointestinal malignancies. Therefore, this study aimed to evaluate the global scientific output and activity with respect to nutritional support and gastrointestinal malignancy.METHODS: We searched in Scopus for publications on gastrointestinal cancer and nutritional assistance published between January 2002 and December 2021. Then, using VOSviewer 1.6.18 and Microsoft Excel 2013, we conducted bibliometric analysis and visualization.
    RESULTS: A total of 906 documents were published between 2002 and 2021, including 740 original articles (81.68%) and 107 reviews (11.81%). China ranked first (298 publications, 32.89%), Japan ranked second (86 publications, 9.49%) and the USA ranked third (84 publications, 9.27%). The organisation with the highest number of publications was the Chinese Academy of Medical Sciences & Peking Union Medical College from China, with 14 articles, followed by the Peking Union Medical College Hospital from China and the Hospital Universitari Vall d'Hebron from Spain (13 publications for each). Before 2016, most studies focused on 'nutrition support for patients undergoing gastrointestinal surgery'. However, the latest trends showed that 'nutrition support and clinical outcomes in gastrointestinal malignancies' and 'malnutrition in patients with gastrointestinal cancer' would be more widespread in the future.
    CONCLUSIONS: This review is the first bibliometric study to provide a thorough and scientific analysis of gastrointestinal cancer and nutritional support trends worldwide over the last 20 years. This study can aid researchers in decision-making by helping them understand the frontiers and hotspots in nutrition support and gastrointestinal cancer research. Future institutional and international collaboration is expected to accelerate the advancement of gastrointestinal cancer and nutritional support research and investigate more efficient treatment methods.
    Keywords:  Gastrointestinal malignancy; Immunonutrition; Nutrition support; Scopus; VOSviewer
    DOI:  https://doi.org/10.1007/s00520-023-07645-2
  52. Antioxidants (Basel). 2023 Feb 08. pii: 414. [Epub ahead of print]12(2):
    Honey's Antioxidant and Antimicrobial Properties: A Bibliometric Study.
    Christos Stefanis, Elisavet Stavropoulou, Elpida Giorgi, Chrysoula Chrysa Voidarou, Theodoros C Constantinidis, Georgia Vrioni, Athanasios Tsakris.
      Research attention has been drawn to honey's nutritional status and beneficial properties for human health. This study aimed to provide a bibliometric analysis of honey's antioxidant and antimicrobial properties. The research advancements within this field from 2001 to 2022 were addressed using the Scopus database, R, and VOSviewer. Of the 383 results, articles (273) and reviews (81) were the most common document types, while the annual growth rate of published manuscripts reached 17.5%. The most relevant topics about honey's antimicrobial and antioxidant properties were related to the agricultural and biological sciences, biochemistry, and pharmacology. According to a keyword analysis, the most frequent terms in titles, abstracts, and keywords were honey, antimicrobial, antioxidant, bee, propolis, phenolic compounds, wound, antibacterial, anti-inflammatory, and polyphenols. A trend topic analysis showed that the research agenda mainly encompassed antioxidants, pathogens, and anti-infection and chemical agents. In a co-occurrence analysis, antioxidants, anti-infection agents, and chemistry were connected to honey research. The initial research focus of this domain was primarily on honey's anti-inflammatory and antineoplastic activity, wound healing, and antibacterial agents. The research agenda was enriched in the subsequent years by pathogens, propolis, oxidative stress, and flavonoids. It was possible to pinpoint past trends and ongoing developments and provide a valuable insight into the field of honey research.
    Keywords:  R bibliometrix; VOSviewer; antimicrobial; antioxidant; bibliometric; honey
    DOI:  https://doi.org/10.3390/antiox12020414
  53. Front Microbiol. 2023 ;14 1091060
    A bibliometric analysis of the role of microbiota in trauma.
    Runzhi Huang, Yuwei Lu, Minghao Jin, Yifan Liu, Mengyi Zhang, Shuyuan Xian, Zhengyan Chang, Lei Wang, Wei Zhang, Jianyu Lu, Xirui Tong, Siqiao Wang, Yushu Zhu, Jie Huang, Luofeng Jiang, Minyi Gu, Zongqiang Huang, Minjuan Wu, Shizhao Ji.
      Introduction: Over the last several decades, the gut microbiota has been implicated in the formation and stabilization of health, as well as the development of disease. With basic and clinical experiments, scholars are gradually understanding the important role of gut microbiota in trauma, which may offer novel ideas of treatment for trauma patients. In this study, we purposed to summarize the current state and access future trends in gut microbiota and trauma research.Methods: We retrieved relevant documents and their published information from the Web of Science Core Collection (WoSCC). Bibliometrix package was responsible for the visualized analysis.
    Results: Totally, 625 documents were collected and the number of annual publications kept increasing, especially from 2016. China published the most documents while the USA had the highest local citations. The University of Colorado and Food & Function are respectively the top productive institution and journal, as PLOS One is the most local cited journal. With the maximum number of articles and local citations, Deitch EA is supported to be the most contributive author. Combining visualized analysis of keywords and documents and literature reading, we recognized two key topics: bacteria translocation in trauma and gut microbiota's effect on inflammation in injury, especially in nervous system injury.
    Discussion: The impact of gut microbiota on molecular and pathological mechanism of inflammation is the focus now. In addition, the experiments of novel therapies based on gut microbiota's impact on trauma are being carried out. We hope that this study can offer a birds-eye view of this field and promote the gradual improvement of it.
    Keywords:  bibliometrics; bibliometrix; gut microbiota; inflammation; trauma
    DOI:  https://doi.org/10.3389/fmicb.2023.1091060
  54. Front Immunol. 2023 ;14 1094437
    Immunotherapy in cervical cancer: From the view of scientometric analysis and clinical trials.
    Yang Xing, Feroza Yasinjan, Yajie Du, Huayue Geng, Ying Zhang, Minghua He, Rui Guo, Lei Yang, Jiayue Cui, Dongmei Mu, Ziling Liu, Hong Wang.
      Background: Cervical cancer is the fourth most cancer and the fourth leading cause of cancer-related deaths in women worldwide. Current treatment for patients with advanced cervical cancer is limited. And in the urgent demand for novel effective therapies both as the first and the second line treatment for these patients, immunotherapy is developing fast and has made some achievements.Methods: This study incorporated 1,255 topic-related articles and reviews from 1999 to 2022 in the Web of Science Core Collection (WoSCC). The WoS platform, Citespace, and VOS viewer provided the annual distribution of publications and citations, the analysis of researching countries and institutions, references, keywords (co-occurrence analysis, burst analysis, and timeline view analysis), and researching authors, respectively. For clinical trials, 720 trials and 114 trials from ClinicalTrials.gov and ICTRP were retrieved, respectively. And 296 trials were finally incorporated into the analysis.
    Results: The scientometric analysis showed that the study of immunotherapies in cervical cancer developed fast in recent years. Most publications were from the United States, followed by China. Seven of the top 10 co-cited references belong to clinical trials, and five of them were published in recent five years. There are lots of clinical trials us specific treatment patterns, some of which have represented excellent effects.
    Conclusions: Both the scientometric analysis of the 1,255 publications and the analysis of clinical trials showed that the field of immunotherapies in cervical cancer developed so fast in recent years. It was found that a lot of clinical trials using various immunotherapies (mainly vaccine therapy, adoptive cell therapy, immune checkpoint blockade, and antibody-drug conjugate) for advanced cervical cancer are currently ongoing or have represented considerable effect. Centered in immunotherapies, immune checkpoint blockades have represented great efficacy and huge potential, especially combined with other therapies such as chemotherapy, targeted therapy, and other immunotherapies.
    Keywords:  HPV; cervical cancer; clinical trials; immunotherapy; scientometric analysis
    DOI:  https://doi.org/10.3389/fimmu.2023.1094437
  55. Heliyon. 2023 Feb;9(2): e13487
    A bibliometric analysis of research on tourism content marketing: Background knowledge and thematic evolution.
    Phuong Minh Binh Nguyen, Xuan Lan Pham, Giang Nu To Truong.
      Content marketing is becoming an important trend in the tourism industry and is attracting the attention of many stakeholders. Previous studies have sporadically highlighted only some content marketing aspects, but none comprehensively described the topic. To fill this gap, this study adopts a comprehensive approach by combining two bibliometric co-citation and co-keyword analysis methods of 659 articles on content marketing in travel sectors. The co-citation results indicate that tourism content marketing research has been concentrated on the themes of (1) the impact of electronic word of mouth (eWOM) and word of mouth (WOM) on business performance; (2) the role of social media, user-generated content (UGC) and destination image formulation; (3) the impact of eWOM and UGC on the decision-making process; as well as (4) opportunities and challenges. Additionally, based on the co-keyword analysis, hot research topics are explored, including online review implementation; UGC implementation; communication and information search; customer behavior prediction model; the decision-making process; and issues related to user experience, quality, and management. Among these, UGC implementation is the most likely trend that researchers can develop in the future. In addition, the influence of other types of UGC (e.g., user-generated travel videos) is a promising avenue for future research. This study will help researchers understand the role and influence of tourism content marketing. Furthermore, tourism marketers can use content marketing to restore destination image and address last-minute booking issues after the COVID-19 pandemic.
    Keywords:  Bibliometric; Co-citation; Co-word; Content marketing; Tourism
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13487
  56. J Funct Biomater. 2023 Feb 13. pii: 103. [Epub ahead of print]14(2):
    Global Trends and Future Research Directions for Temporomandibular Disorders and Stem Cells.
    Zuleni Alexandre da Silva, Wallacy Watson Pereira Melo, Hadassa Helez Neves Ferreira, Rafael Rodrigues Lima, Renata Duarte Souza-Rodrigues.
      Temporomandibular disorder (TMD) is an umbrella term used to describe various conditions that affect temporomandibular joints, masticatory muscles, and associated structures. Although the most conservative and least invasive treatment is preferable, more invasive therapies should be employed to refractory patients. Tissue engineering has been presented as a promising therapy. Our study aimed to investigate trends and point out future research directions on TMD and stem cells. A comprehensive search was carried out in the Web of Science Core Collection (WoS-CC) in October 2022. The bibliometric parameters were analyzed through descriptive statistics and graphical mapping. Thus, 125 papers, published between 1992 and 2022 in 65 journals, were selected. The period with the highest number of publications and citations was between 2012 and 2022. China has produced the most publications on the subject. The most frequently used keywords were "cartilage", "temporomandibular joint", "mesenchymal stem cells", and "osteoarthritis". Moreover, the primary type of study was in vivo. It was noticed that using stem cells to improve temporomandibular joint repair and regeneration is a significant subject of investigation. Nonetheless, a greater understanding of the biological interaction and the benefits of using these cells in patients with TMD is required.
    Keywords:  stem cells; temporomandibular disorders; temporomandibular joint; tissue engineering
    DOI:  https://doi.org/10.3390/jfb14020103
  57. Environ Sci Pollut Res Int. 2023 Feb 25.
    The impact of brick kilns on environment and society: a bibliometric and thematic review.
    Muhammad Arham Parvez, Irfan Ahmad Rana, Adnan Nawaz, Hafiz Syed Hamid Arshad.
      Bricks have a long history of being utilized as a construction material across the globe. The production processes involved in the manufacture of bricks have a significant impact on the environment, human health, economy, and society. This study conducts a thematic and bibliometric analysis to provide an in-depth review of the effects of brick kilns on humans and the environment. The PRISMA framework was used to identify relevant articles from the Web of Science database, resulting in the selection and critical review of 348 articles. The bibliometric analysis included an evaluation of historical growth, keywords, citation and co-citation, organizations, and countries. The articles were published in 213 journals, written by 1396 authors from 670 institutions in 66 countries. Thematic analysis revealed that brick kilns have a negative impact on the environment, including soil damage, and cause health problems for kiln workers and animals. Modern slavery and societal issues also persist in developing countries. The current research is focused on finding alternative materials for brick manufacturing, improving industry energy efficiency, managing waste, and technological advancements, such as the implementation of the zigzag or Hoffmann kiln to reduce pollution. In developing countries, utilizing waste from other industries in brick production can effectively lower production costs. While developed countries have embraced advanced technologies for brick production, it is recommended that developing countries adopt awareness campaigns to encourage the upgrading of kilns to cleaner and more sustainable systems. Future research directions should aim to support brick kiln owners in adopting such systems.
    Keywords:  Air pollution; Climate change; Energy efficiency; Recycling; Smog; Waste management
    DOI:  https://doi.org/10.1007/s11356-023-26011-7
  58. J Surg Res. 2023 Feb 16. pii: S0022-4804(22)00798-3. [Epub ahead of print]286 104-109
    The Use of Facial Recognition Software and Published Manuscripts to Examine Trends in Surgical Editorial Board Diversity.
    Christian Toney, Michelle Shroyer Mathis, Colin Martin.
      INTRODUCTION: Recent social justice movements have highlighted the need for improved diversity and inclusion. These movements have emphasized the need for inclusivity of all genders and races in all sectors including surgical editorial boards. There is currently not an established, standardized method to assess the gender, racial, and ethnic makeup of surgical editorial board rosters, yet artificial intelligence is a method that can be utilized to determine gender and race in an unbiased manner. The aim of the present study is to determine if recent social justice movements correlate with an increase in diversity-themed articles published and if there is an increase in the gender and racial makeup of surgical editorial boards determined by artificial intelligence software.METHODS: Impact factor was used to assess and rank highly regarded general surgery journals. The website of each of these journals was examined for pledges of diversity in their mission statements and core beliefs of conduct. To determine the number of diversity-themed articles that were published during 2016 and 2021, each surgical journal was analyzed for diversity-themed articles using 10 specific keywords in PubMed. To determine the racial and gender makeup of editorial boards in 2016 and 2021, we obtained the current and the 2016 editorial board roster. Roster member images were collected from academic institutional websites. Betaface facial recognition software was used to assess the images. The software assigned the gender, race and ethnicity of the image supplied. Betaface results were analyzed using a Chi Square Test of Independence.
    RESULTS: We analyzed 17 surgical journals. Only four of 17 journals were found to have diversity pledges on their website. For diversity themed publications, 1% of articles in 2016 and 2.7% in 2021 were published specifically about diversity. There was a significant increase in the amount of diversity articles/journal published per year in 2016 (6.59) compared to 2021 (25.94, P < 0.001). There was no correlation between impact factor and articles that publish diversity keywords. 1968 editorial board member images were analyzed using Betaface software to determine gender and race in both time periods. There was no significant increase in diversity of editorial board members regarding gender, race, and ethnicity temporally from 2016 to 2021.
    CONCLUSIONS: In the present study, we found that although the number of diversity-themed articles has increased over the last 5 y, however the gender and racial makeup of surgical editorial boards has not changed. Further initiatives are needed to better track and diversify the gender and racial composition of surgical editorial boards.
    Keywords:  Disparities; Diversity; Facial recognition; Gender; Race; Surgical quality
    DOI:  https://doi.org/10.1016/j.jss.2022.11.057
  59. Front Neurol. 2023 ;14 913855
    A bibliometric analysis on traumatic brain injury in forensic medicine of a half-century (1972-2021).
    Yufang Wang, Qianqian Chen, Xingxing Dang, Wanqing Lu, Xinran Zhang, He Yan, Shuliang Niu, Xisheng Yan, Jie Yan.
      Traumatic brain injury (TBI) is among the most common injuries in forensic medicine, the identification of which is of particular importance in forensic practice. To reveal the circumstances and trends of TBI in the forensic field, we used the Web of Science (WoS) database for comprehensive retrieval. We made a metrological analysis of 1,089 papers in the past 50 years (1972-2021). The United States and Germany have the most forensic research on TBI. Diffuse axonal injury (DAI) has been the focus of attention for many years, and much effort has been devoted to its diagnosis in forensic pathology. Infants and children are the subgroups of most concern, especially in infant and child abuse cases. Research on identifying shaken baby syndrome has received increasing attention in recent years. Overall, our study provides a comprehensive list and analysis of the articles regarding TBI in legal medicine, which may shed light on recognizing the trends and research hotspots in this field.
    Keywords:  bibliometric analysis; concussion; diffuse axonal injury; shaken baby syndrome; traumatic brain injury
    DOI:  https://doi.org/10.3389/fneur.2023.913855
  60. Photodermatol Photoimmunol Photomed. 2023 Feb 21.
    Wider indications and more efficient drug delivery: A bibliometric analysis and visualization of photodynamic therapy in skin cancer.
    Zixi Jiang, Yantao Xu, Zirui Zhu, Yuancheng Liu, Liang Zhang, Dan Jian.
      BACKGROUND: Photodynamic therapy (PDT) has been widely accepted in keratocyte carcinoma and an increasing number of literatures concerning PDT in skin cancer is published. But a detailed examination of publication patterns of PDT in skin cancer has not yet been carried out.METHODS: Bibliographies were retrieved from Web of Science Core Collection restricted the publication date from January 1, 1985 to on 31 December 2021. The search terms were photodynamic therapy and skin cancer. Visualization analysis and statistical analysis were performed by VOSviewer (Version 1.6.13), R software (Version 4.1.2) and Scimago Graphica (Version 1.0.15).
    RESULTS: 3,248 documents were selected for analysis. The results showed that the number of annual publications related to PDT in skin cancer was gradually increased and would continue to increase in the future. The results illustrated that "melanoma", "nanoparticles", "drug-delivery", "mechanism", "delivery" and "in-vitro" are newly occurred topics. The most prolific country was the United States and the most productive institution was the University of Sao Paulo in Brazil. German researcher Szeimies RM published the most papers related to PDT in skin cancer. British Journal of Dermatology was the most popular journal in this field.
    CONCLUSION: The topic that PDT in skin cancer is a heated issue. Our study revealed the bibliometric result of the field, which might provide the prospects for further research. We recommend future investigations focusing on PDT in treating melanoma, innovation of photosensitizer, improvement of drug delivery and the mechanism of PDT in skin cancer.
    Keywords:  PDT; bibliometric analysis; drug delivery; mechanism; melanoma; photodynamic therapy; photosensitizer; skin cancer
    DOI:  https://doi.org/10.1111/phpp.12868
  61. Aging Dis. 2023 Feb 01. 14(1): 6-8
    A Bibliometric Analysis of Aging in COVID-19.
    Weiming Guo, Jinglei Zang, Jingfen Lu, Yanqiuzi Ma, Gang Fan.
      
    DOI:  https://doi.org/10.14336/AD.2022.0620
  62. Heliyon. 2023 Jan;9(1): e13039
    Crafts as a key factor in local development: Bibliometric analysis.
    David Fernández Bellver, M Belén Prados-Peña, Ana M García-López, Valentín Molina-Moreno.
      The role of crafts on a global level has accrued importance at present, both for developing countries and for rural development in general. Governments and institutions are increasingly trying to promote rural development to fight against the flight of the population from rural areas. Crafts is considered an important tool for local economic development and job creation. The goal of this study is to use bibliometric analysis to analyze the advances in research in the field of crafts and their influence on the development of rural communities. It also aims to identify the main lines of research that are currently being addressed as future trends. This analysis has provided a global, systematic and visual overview of the 1379 studies related to the role of crafts in the development of rural areas, published from 1954, year in which the first publication appeared, up to 2021. Growth trends have been identified in the number of articles published, magazines, authors, institutions and most productive countries. Results have shown that the most popular lines of research on this subject are those in which crafts are considered a source of income for local communities, particularly linked to tourism, job creation and sustainability in the first place; followed by research on the demographic and economic effects of new craft products and processes on rural areas; and those that consider crafts as a factor to mitigate poverty in the rural world. Therefore, the concept of handicrafts as a source of livelihood for poor rural regions is primarily emphasized.
    Keywords:  Bibliometric analysis; Crafts; Local development; Sustainable development
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13039
  63. Front Sociol. 2023 ;8 1134518
    The role of open data in digital society: The analysis of scientific trending topics through a bibliometric approach.
    Maria Carmela Catone.
      The analysis of contemporary society, characterized by technological, economic, political, social, and cultural changes, has become more challenging due to the development of the internet and information and communication technologies, which provide a vast and increasingly valuable source of information, knowledge, and data. Within this context, so-called open data-that is, data that are made public, especially by public administrations, through an open governance model (transparent and accessible to citizens) are assuming a significant role. This is a topic of growing importance that scientific research is addressing in an attempt to discern the multiplicity of social, educational, legal, technological, statistical, and methodological issues that underlie the creation and use of such data. This article aims to provide insights into understanding scientific trends on the topic of open data through a bibliometric approach. Specifically, a total of 3,110 publications related to the disciplinary fields of the social sciences and humanities published from 2013 to 2022 were collected. The data was then analyzed using network and factorial analysis techniques to detect the conceptual structure to identify the trends of topics and perspectives of research that characterize open data studies.
    Keywords:  bibliometric analysis; conceptual structure; open data; research trends; science mapping
    DOI:  https://doi.org/10.3389/fsoc.2023.1134518
  64. Dent J (Basel). 2023 Feb 01. pii: 36. [Epub ahead of print]11(2):
    A Bibliometric Analysis on the Early Works of Dental Anxiety.
    Andy Wai Kan Yeung.
      Dental anxiety has been a common phenomenon under investigation for decades. This report aimed to identify the historical roots of dental anxiety in the research literature. The literature database Web of Science Core Collection was searched to identify relevant papers on this theme. Cited reference analysis on the collected literature set was performed with CRExplorer, a dedicated bibliometric software. This analysis successfully identified the references dealing with dental anxiety in the late 1800s and early 1900s. They included essays that provided expert opinion on dental anxiety, reported semi-structured interviews to elucidate its underlying reasons, introduced psychometric scales to assess dental anxiety, and proposed theories and arguments from psychoanalytic aspects. Several references dealing with anxiety in general were also identified. To conclude, cited reference analysis was useful in revealing the historical origins of dental anxiety research. These cited references provided a concrete foundation to support subsequent dental anxiety research.
    Keywords:  anxiety; bibliometric; dentistry; fear; history; psychology
    DOI:  https://doi.org/10.3390/dj11020036
  65. Psychiatr Genet. 2023 Feb 24. pii: e000336. [Epub ahead of print]
    Gene and schizophrenia in the pregenome and postgenome-wide association studies era: a bibliometric analysis and network visualization.
    Wan Nur Amalina Zakaria, Teguh Haryo Sasongko, Badryia Al-Rahbi, Noorah Al-Sowayan, Asma Hayati Ahmad, Rahimah Zakaria, Aidi Ahmi, Zahiruddin Othman.
      This study aimed to perform a bibliometric analysis on genetic studies in schizophrenia in the pregenome-wide association studies (GWAS) and post-GWAS era. We searched the literature on genes and schizophrenia using the Scopus database. The documents increased with time, especially after the human genome project and International HapMap Project, with the highest citation in 2008. The top occurrence author keywords were discovered to be different in the pre-GWAS and post-GWAS eras, reflecting the progress of genetic studies connected to schizophrenia. Emerging keywords highlighted a trend towards an application of precision medicine, showing an interplay of environmental exposures as well as genetic factors in schizophrenia pathogenesis, progression, and response to therapy. In conclusion, the gene and schizophrenia literature has grown rapidly after the human genome project, and the temporal variation in the author keywords pattern reflects the trend of genetic studies related to schizophrenia in the pre-GWAS and post-GWAS era.
    DOI:  https://doi.org/10.1097/YPG.0000000000000336
  66. Curr Oncol. 2023 Jan 29. 30(2): 1626-1647
    Artificial Intelligence for Cancer Detection-A Bibliometric Analysis and Avenues for Future Research.
    Erik Karger, Marko Kureljusic.
      After cardiovascular diseases, cancer is responsible for the most deaths worldwide. Detecting a cancer disease early improves the chances for healing significantly. One group of technologies that is increasingly applied for detecting cancer is artificial intelligence. Artificial intelligence has great potential to support clinicians and medical practitioners as it allows for the early detection of carcinomas. During recent years, research on artificial intelligence for cancer detection grew a lot. Within this article, we conducted a bibliometric study of the existing research dealing with the application of artificial intelligence in cancer detection. We analyzed 6450 articles on that topic that were published between 1986 and 2022. By doing so, we were able to give an overview of this research field, including its key topics, relevant outlets, institutions, and articles. Based on our findings, we developed a future research agenda that can help to advance research on artificial intelligence for cancer detection. In summary, our study is intended to serve as a platform and foundation for researchers that are interested in the potential of artificial intelligence for detecting cancer.
    Keywords:  artificial intelligence; bibliometric study; cancer detection; deep learning; machine learning
    DOI:  https://doi.org/10.3390/curroncol30020125
  67. Heliyon. 2023 Feb;9(2): e13406
    A systematic review of urban green space research over the last 30 years: A bibliometric analysis.
    Jenő Zsolt Farkas, Edit Hoyk, Mariana Batista de Morais, György Csomós.
      Worldwide, due to rapid urbanization, the provision of urban green spaces (UGSs) has become a primary goal of urban planning. As such, research on the benefits, effects, and challenges of UGSs has gained widespread attention among scholars. This paper comprehensively analyzes three decades of UGS research and its evolution; it conducts a bibliometric analysis of approximately 4000 articles and reviews from the Web of Science platform to discover the patterns and trends characterizing UGS research over time. We found that the pioneers of initial UGS research were the United States and Canada, whereas recently the European Union and China have become the global engines of research in the field. UGS research initially focused on studying urban forests, gradually shifting toward green spaces located in inner urban areas. Early on, researchers investigated UGSs (i.e., urban forests) from an ecological perspective. However, the most current research phase focuses on the social aspects of UGSs, characterized by such keywords as environmental justice and accessibility. Furthermore, the introduction of geographic information systems (GIS) has given new impetus to the evolution of UGS research and has remained the most used technological advancement besides remote sensing techniques. As the social aspects of UGS research have gained importance, new research methods have been employed, such as machine learning, big data and social media data analysis, and artificial intelligence, most recently.
    Keywords:  Bibliometric analysis; Keyword burst; Keyword cluster; Urban forest; Urban green space; VOS Viewer
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e13406
  68. Environ Sci Pollut Res Int. 2023 Feb 21.
    Visual analysis of greenhouse gas emissions from sewage treatment plants based on CiteSpace: from the perspective of bibliometrics.
    Yidi Zhang, Xiaohang Ni, Hongtao Wang.
      With the global reduction actions of greenhouse gas (GHG) emissions, environmental facilities, including sewage treatment plants (STPs), need to reduce pollutants while minimizing GHG emissions. Therefore, more and more publications revealed the formation mechanism of GHGs in STPs and committed to finding better reduction schemes. From the perspective of bibliometrics, this study used CiteSpace to conduct quantitative and visual analysis based on 1,543 publications retrieved from Web of Science between 2000 and 2021 around the world. We have systematically evaluated the structure, development trend, hot spots, and research frontier in the field of GHG emissions from STPs and compared with the contents of top journals to verify the scientificity of the analysis. The results show that the number of publications has increased year by year, and the networks of authors and institutions show a strong correlation. Among them, the clusters of nitrous oxide, anaerobic digestion, and life cycle assessment (LCA) started earlier and received extensive attention, which derived other clusters in the research process. With the development of the field, researchers have gradually changed from single water treatment facilities to multi-carriers that can realize energy regeneration and utilization simultaneously. Accordingly, the GHG reduction of STPs through energy regeneration and resource recovery has become a hot point and frontier direction, which also challenges the breakthroughs in relevant technologies. Furthermore, it provides scientific support for the formulation of relevant incentive policies and economic subsidy systems, so as to alleviate the pressure of global warming and realize the sustainable development of STPs concurrently.
    Keywords:  Bibliometrics; CiteSpace; Greenhouse gas emissions; Nitrous oxide; Sewage treatment plant; Wastewater
    DOI:  https://doi.org/10.1007/s11356-023-25582-9
  69. JSES Int. 2023 Jan;7(1): 158-161
    Research on artificial intelligence in shoulder and elbow surgery is increasing.
    Puneet Gupta, Erick M Marigi, Joaquin Sanchez-Sotelo.
      Background: Total health care spending in the United States is increasing. In order to improve our delivery of high-quality, patient-centric, and cost-effective care, artificial intelligence (AI) and its subsets are being increasingly explored and utilized in medicine. Applications of AI in orthopedic surgery, including shoulder and elbow surgery, are being actively studied and have stirred much discussion. However, the trends of research on AI applications in shoulder and elbow surgery have not yet been quantified. Thus, the purpose of this study is to explore the general trends of research in applying AI to shoulder and elbow surgery and to examine characteristics of these research publications.Methods: A literature search was conducted using PubMed for all articles published between January 1, 2000 and May 12, 2022. The primary search query used was as follows: (shoulder) and (AI OR machine learning OR deep learning OR neural networks). Exclusion criteria were as follows: (1) not pertinent to orthopedic surgeons (2) not pertaining to shoulder or elbow surgery, and (3) not pertaining to AI, machine learning, and deep learning. Selected articles in high-impact and relevant orthopedic journals were further characterized and analyzed.
    Results: The annual number of articles increased from 1 article in 2006 to 24 articles in 2021. There was a 4-fold increase in publications between 2019 and 2021, and a 6-fold increase between 2018 and 2021. The average number of publications per year increased exponentially from 2010 to 2021 (R2 = 0.608; P = .003). The three journals with the most publications were Journal of Shoulder and Elbow Surgery (12), followed by Arthroscopy (2), and Clinical Orthopaedics and Related Research (2).
    Conclusion: This study provides quantitative evidence for the first time that publications applying AI and its subsets to shoulder and elbow surgery are growing exponentially since the year 2010, with the most rapid growth beginning between the years of 2019 and 2020.
    Keywords:  Artificial intelligence; Deep learning; Elbow; Machine learning; Shoulder; Trends
    DOI:  https://doi.org/10.1016/j.jseint.2022.10.004
  70. Am Psychol. 2023 Feb 23.
    The problem of miscitation in psychological science: Righting the ship.
    Cory L Cobb, Brianna Crumly, Pablo Montero-Zamora, Seth J Schwartz, Charles R Martínez.
      Scholarly citation represents one of the most common and essential elements of psychological science, from publishing research, to writing grant proposals, to presenting research at academic conferences. However, when authors mischaracterize prior research findings in their studies, such instances of miscitation call into question the reliability and credibility of scholarship within psychological science and can harm theory development, evidence-based practices, knowledge growth, and public trust in psychology as a legitimate science. Despite these implications, almost no research has considered the prevalence of miscitation in the psychological literature. In the largest study to date, we compared the accuracy of 3,347 citing claims to original findings across 89 articles in eight of top psychology journals. Results indicated that, although most (81.2%) citations were accurate, roughly 19% of citing claims either failed to include important nuances of results (9.3%) or completely mischaracterized findings from prior research altogether (9.5%). Moreover, the degree of miscitation did not depend on the number of authors on an article or the seniority of the first authors. Overall, results indicate that approximately one in every 10 citations completely mischaracterizes prior research in leading psychology journals. We offer five recommendations to help authors ensure that they cite prior research accurately. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
    DOI:  https://doi.org/10.1037/amp0001138
  71. Ear Nose Throat J. 2023 Feb 23. 1455613231158795
    Association of Practice Setting and Scholarly Activity With Medicolegal Claims in Otolaryngology-Head and Neck Surgery.
    Kasra Ziai, Shivam Patel, Megan Crenshaw, Robert Saadi, David Goldenberg, Jessyka G Lighthall.
      OBJECTIVE: To characterize the association between scholarly activity, academic rank, practice setting, and malpractice claims among otolaryngologists over the past decade.METHODS: Data was extracted from the two legal databases, WestLaw and LexisNexis. The records were obtained from January 2010 to January 2020. Scopus and PubMed databases were used to identify bibliometric data.
    RESULTS: Of the 102 malpractice cases identified, 77.5% (N = 79) were ruled in favor of the defendant, 13.7% (N = 14) in favor of the plaintiff, and 8.8% (N = 9) were settled outside of the court. A total amount of $46,533,346.82 was rewarded to plaintiffs in 14 cases. Endoscopic sinus surgery was the procedure associated with the most malpractice claims (N = 16). Alleged improper performance (N = 51) was the most common underlying reason for litigation. Of the 102 defendant surgeons, 82 (80.4%) were in community/private settings. Among the 14 cases in that a surgeon was found at fault, 13 (92.8%) were in the community/private setting. Among the surgeons with at least one publication, the mean Hirsch Index (h-index) was 8.2. There was a statistically significant correlation between the mean h-index and litigation outcome (95% CI: -8.9 to -0.9, P = .017).
    CONCLUSION: Our analysis showed that most malpractice litigations were among otolaryngologists practicing in community/private settings. We also found that higher scholarly activity measured by the h-index was associated with verdicts in favor of the defendant/surgeon. This study was limited by not all-inclusive aspects of the legal databases that were used, the small sample size, and the lack of multivariable analysis.
    Keywords:  academia; h-index; litigation; malpractice; otolaryngology; scholarly activity
    DOI:  https://doi.org/10.1177/01455613231158795
  72. Mil Med. 2023 Feb 20. pii: usad033. [Epub ahead of print]
    The Power of Cooperation: A Quantitative Analysis of the Benefit of Civilian Partnerships on the Academic Output of Military Surgeons.
    Elise E H Fannon, Peter A Learn, John D Horton, Kerry P Latham, Ian L Valerio.
      INTRODUCTION: Military-civilian partnerships are crucial to maintaining the skills of active duty surgeons and sustaining readiness. There have been no publications to date that report the quantitative effect of these partnerships on academic research. To address this question, the Hirsch indices (H-indices) of active duty surgeons with a civilian affiliation (CA) were compared to those without. As a secondary outcome, H-indices of military surgeons with and without an appointment to the Uniformed Services University (USU) were similarly compared. We hypothesized that military surgeons with a CA would have a higher H-index as compared to those without.MATERIALS AND METHODS: Rosters of active duty military surgeons were obtained confidentially through each branch consultant. H-indices were found on Scopus. Graduation dates and hospital affiliations were identified via public Doximity, LinkedIn profiles, and hospital biographies. Rosters were cross-referenced with USU appointments. Stata software was used for final analysis.
    RESULTS: Military surgeons without a civilian association have a median H-index of 2 versus 3 in those with such an affiliation (P = .0002). This pattern is also seen in average number of publications, at 3 and 5 articles (P < .0001). When further stratified by branch, Air Force surgeons have median H-indices of 2.5 and 1 with and without a CA, respectively (P = .0007). The Army surgeons follow a similar pattern, with median H-indices of 5 and 3 for those with and without affiliations, respectively (P = .0021). This significance does not hold in the Naval subgroup. Similar results are found for the secondary outcome of USU appointment, with median H-indices of 3 and 2 in those with and without CAs, respectively (P < .0001). In the multivariable negative binomial regression model, both CA and USU appointment significantly increased H-index in the overall cohort, with incidence rate ratios of 1.32 (95% CI = 1.08, 1.61) and 1.56 (95% CI = 1.28, 1.91), respectively.
    CONCLUSION: This article provides objective evidence that there is a benefit to military-civilian partnerships on the academic output of military surgeons. These relationships should continue to be fostered and expanded.
    DOI:  https://doi.org/10.1093/milmed/usad033
  73. Scientometrics. 2023 Feb 11. 1-9
    Empirical relationship between the number of review and research articles.
    Petr Praus.
      In this contribution, an empirical relationship between the number of review and research articles published per year was searched. The simple idea based on proportionality (linearity) between the numbers of both kinds of articles was expressed in terms of a quadratic relationship, in which the quadratic member can reflect negative or positive deviations from the assumed linearity. The quadratic relationship was able to describe beginning periods of research fields as well as their mature phases and to detect the unpredictably high number of review articles. It was verified by the articles published in 20 various research fields taken from the Web of Science during different time spans.Supplementary Information: The online version contains supplementary material available at 10.1007/s11192-023-04654-0.
    Keywords:  Quadratic relationship; Research articles; Review articles
    DOI:  https://doi.org/10.1007/s11192-023-04654-0
  74. Herit Sci. 2023 ;11(1): 30
    Aesthetic value protection and tourism development of the world natural heritage sites: a literature review and implications for the world heritage karst sites.
    Shirong Zhang, Kangning Xiong, Guangyu Fei, Haipeng Zhang, Yongbi Chen.
      Recently, research on outstanding universal value (OUV) protection and tourism development at World Natural Heritage sites (WNHSs) has attracted scholarly attention. The aesthetic value of natural landscapes is a powerful driving force for tourism development. Using this approach as an entry point to study aesthetic value protection and tourism development will help to relieve the contradiction between protection and development and promote the sustainable utilization of heritage sites. However, no comprehensive literature review has examined research on aesthetic value protection and tourism development at WNHSs. To fill this gap, we used a systematic literature review framework, and bibliometric analyses of 194 journal articles were collected from the Web of Science (WOS) and China National Knowledge Infrastructure (CNKI) databases. The results show the following: (1) the overall fluctuating upward trend in the number of publications indicates that the research in this field is gradually expanding, the regions studied in the literature are mainly focused on China, Italy and Australia, and the research institutions conducting the research are mainly Asian universities. (2) The landmark research achievements mainly focus on theoretical foundation, model construction, monitoring and evaluation, technical measures and other dimensions and the implications for World Heritage karst sites (WHKSs), where theoretical research is the main focus, and that research on monitoring and evaluation, technical measures and model construction is relatively limited. (3) On this basis, 7 key scientific and technological issues are summarized and provide insights into future research directions for the conservation of aesthetic values and tourism development at WHKSs, and future research should strengthen knowledge of natural heritage conservation based on aesthetic value identification and focus on the theoretical basis of the coordination between the conservation of aesthetic value and tourism development at WNHSs. Research should explore the science and technology and measures associated with the coordination between aesthetic value conservation and tourism development, and reveal the mechanisms and paths for coordination between WNHS conservation and tourism development in karst areas.
    Keywords:  Aesthetic value protection; Karst; Literature review; Tourism development; World Natural Heritage sites
    DOI:  https://doi.org/10.1186/s40494-023-00872-0
  75. Can J Surg. 2023 Jan-Feb;66(1):66(1): E88-E92
    Trends in types of graduate degrees and research output for academic general surgeons in Canada.
    Kevin Verhoeff, Kieran Purich, Alexander Miles, Janice Y Kung, A M James Shapiro, David L Bigam.
      SummaryThe proportion of general surgeons with graduate degrees in Canada is increasing. We sought to evaluate the types of graduate degree held by surgeons in Canada, and whether differences in publication capacity exist. We evaluated all general surgeons working at English-speaking Canadian academic hospitals to determine the types of degrees achieved, changes over time and research output associated with each degree. We identified 357 surgeons, of whom 163 (45.7 %) had master's degrees and 49 (13.7 %) had PhDs. Achievement of graduate degrees increased over time, with more surgeons earning master's degrees in public health (MPH), clinical epidemiology and education (MEd), and fewer master's degrees in science (MSc) or PhDs. Most publication metrics were similar by degree type, but surgeons with PhDs published more basic science research than those with clinical epidemiology, MEd or MPH degrees (2.0 v. 0.0, p < 0.05); surgeons with clinical epidemiology degrees published more first-author articles than surgeons with MSc degrees (2.0 v. 0.0, p = 0.007). An increasing number of general surgeons hold graduate degrees, with fewer pursuing MSc and PhD degrees, and more holding MPH or clinical epidemiology degrees. Research productivity is similar for all groups. Support to pursue diverse graduate degrees could enable a greater breadth of research.
    DOI:  https://doi.org/10.1503/cjs.020721
  76. New Microbes New Infect. 2023 Mar;52 101094
    The most influential COVID-19 articles: A systematic review.
    Suhaib Js Ahmad, Konstantinos Degiannis, Joseph Borucki, Sjaak Pouwels, David Laith Rawaf, Marion Head, Chun Hei Li, Rami Archid, Ahmed R Ahmed, Anil Lala, Wasif Raza, Katie Mellor, Doerte Wichmann, Aristomenis Exadaktylos.
      Background: Since December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),causative pathogen of coronavirus disease 2019 (COVID-19), has triggered a pandemic with challenges for health care systems around the world. Researchers have studied and published on the subject of SARS-CoV-2 and the disease extensively. What is the significance of articles published, shared and cited in the early stages of such a pandemic?Materials and methods: A systematic literature search in a time frame of 12 months and analysis rating using Principle Component Analysis (PCA) and Multiple Factor Analysis (MFA) were performed.
    Results: The 100 most cited COVID-19 articles were identified. The majority of these articles were from China (n = 54), followed by United States of America (USA) (n = 21) and United Kingdom (UK) (n = 8). All articles were published in high-ranked, peer-reviewed journals, with research focusing onthe the diagnosis, transmission and therapy of COVID-19. The level of evidence of the 100 most cited COVID-19 articles on average was low.
    Conclusion: In the early stages of a pandemic, new and innovative research can emerge and be highly cited, regardless of the level of evidence.
    Keywords:  COVID-19; Citations; ICU care; Intensive care; SARS-CoV-2
    DOI:  https://doi.org/10.1016/j.nmni.2023.101094
  77. bioRxiv. 2023 Feb 15. pii: 2023.02.14.527522. [Epub ahead of print]
    Automatic identification of scientific publications describing digital reconstructions of neural morphology.
    Patricia Maraver, Carolina Tecuatl, Giorgio A Ascoli.
      Motivation: The increasing number of peer-reviewed publications constitutes a challenge for biocuration. For example, NeuroMorpho.Org, a sharing platform for digital reconstructions of neural morphology, must evaluate more than 6000 potentially relevant articles per year to identify data of interest. Here, we describe a tool that uses natural language processing and deep learning to assess the likelihood of a publication to be relevant for the project.Results: The tool automatically identifies articles describing digitally reconstructed neural morphologies with high accuracy. Its processing rate of 900 publications per hour is not only amply sufficient to autonomously track new research, but also allowed the successful evaluation of older publications backlogged due to limited human resources. The number of bio-entities found since launching the tool almost doubled while greatly reducing manual labor. The classification tool is open source, configurable, and simple to use, making it extensible to other biocuration projects.
    Availability: https://github.com/Joindbre/TextRelevancy.
    Contact: ascoli@gmu.edu.
    Supplementary information: Supplementary information, tool installation, and API usage are available at https://docs.joindbre.com.
    DOI:  https://doi.org/10.1101/2023.02.14.527522
  78. J Ovarian Res. 2023 Feb 18. 16(1): 42
    Past and present: a bibliometric study on polycystic ovary syndrome.
    Mengcheng Cai, Zhexin Ni, Zike Yuan, Jin Yu, Danying Zhang, Ruipin Yao, Ling Zhou, Chaoqin Yu.
      BACKGROUND: Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease that has a great impact on women's physical and mental health. It is a burden to social and patients' economy. In recent years, researchers' understanding of PCOS has reached a new level. However, many PCOS reports have different directions, and overlapping phenomena exist. Therefore, clarifying the research status of PCOS is important. This study aims to summarise the research status of PCOS and predict the hot spots of PCOS in the future by Bibliometricx.RESULTS: The keywords of PCOS research focused on PCOS, insulin resistance (IR), obesity and metformin. Keywords plus co-occurrence network showed that PCOS, IR and prevalence were hot spots in the recent 10 years. Moreover, we found that gut microbiota may be a carrier that can be used to study hormone levels, IR-related mechanisms, prevention and treatment in the future.
    CONCLUSIONS: This study is helpful for researchers to quickly grasp the current situation of PCOS research and enlighten researchers to explore new problems in PCOS.
    Keywords:  Bibliometrics; Gut microbiota; Hot spots; Insulin resistance; Polycystic ovary syndrome; Research progress
    DOI:  https://doi.org/10.1186/s13048-022-01072-3
  79. J Assoc Inf Sci Technol. 2023 Feb;74(2): 205-218
    The NLM indexer assignment dataset: a new large-scale dataset for reviewer assignment research.
    Alastair R Rae, James G Mork, Dina Demner-Fushman.
      MEDLINE is the National Library of Medicine's (NLM) journal citation database. It contains over 28 million references to biomedical and life science journal articles, and a key feature of the database is that all articles are indexed with NLM Medical Subject Headings (MeSH). The library employs a team of MeSH indexers, and in recent years they have been asked to index close to 1 million articles per year in order to keep MEDLINE up to date. An important part of the MEDLINE indexing process is the assignment of articles to indexers. High quality and timely indexing is only possible when articles are assigned to indexers with suitable expertise. This paper introduces the NLM indexer assignment dataset: a large dataset of 4.2 million indexer article assignments for articles indexed between 2011 and 2019. The dataset is shown to be a valuable testbed for expert matching and assignment algorithms, and indexer article assignment is also found to be useful domain-adaptive pre-training for the closely related task of reviewer assignment.
    DOI:  https://doi.org/10.1002/asi.24722
  80. Neurodegener Dis Manag. 2023 Feb 21.
    Parkinson's disease research in Morocco: a review.
    Mohamed Daghi, Abdelhakim Lakhdar, Hicham El Otmani.
      Aim: To quantify and provide an overview on the scientific productivity made by Moroccan academics in the research on Parkinson's disease (PD) and parkinsonism. Materials & methods: Scientific articles, in either English or French, were gathered from published literature in three recognized databases: PubMed, ScienceDirect and Scopus. Results: We identified 95 published papers from which 39 articles have been extracted after removing inadequate publications and duplications between databases. All articles were published between 2006 and 2021. The selected articles were subdivided into five categories. Conclusion: The Moroccan academia is presently facing a low productivity issues and a lack of research laboratories focusing on PD research. We anticipate that providing more budgetary funds will significantly improve the productivity of PD research.
    Keywords:  Moroccan academia; Morocco; Parkinson's disease; PubMed; ScienceDirect; Scopus; parkinsonism; research laboratories; review; scientific productivity
    DOI:  https://doi.org/10.2217/nmt-2022-0021
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