bims-evares Biomed News
on Evaluation of research
Issue of 2023‒11‒05
sixty-six papers selected by
Thomas Krichel, Open Library Society



  1. Hernia. 2023 Oct 28.
      PURPOSE: Incisional hernia (IH) is one of the most common complications after abdominal surgeries and may bring great suffering to patients. This study aims to evaluate the global trends in IH research from 2003 to 2023 and visualize the frontiers using bibliometric analysis.METHODS: The literature search was conducted on the Web of Science for IH studies published from 2003 to 2023 and sorted by citation frequency. The top 100 most-cited articles were analyzed by the annual publication number, prolific countries and institutions, influential author and journal, and the number of citations through descriptive statistics and visualization.
    RESULTS: The top paper was cited 1075 times and the median number of citations was 146. All studies were published between 2003 and 2019 and the most prolific year was 2003 with 14 articles. Jeekel J and Rosen M were regarded as the most productive authors with ten articles each and acquired 2738 and 2391 citations, respectively. The top three institutions with the most productive articles were Erasmus Mc, Carolinas Med Ctr, and Univ Utah, while the top three countries were the United States, Netherlands and Germany. The most frequent keyword was "incisional hernia" with 55 occurrences, followed by "mesh repair", "randomized controlled trial", and "polypropylene".
    CONCLUSION: The 100 most-cited papers related to IH were published predominantly by USA and European countries, with randomized controlled trial (RCT) and observational study designs, addressing topics related to risk factors, complications, mesh repair, and mesh components.
    Keywords:  Bibliometric analysis; Citation; Incisional hernia; Progression; Trend
    DOI:  https://doi.org/10.1007/s10029-023-02909-6
  2. Skin Appendage Disord. 2023 Oct;9(5): 333-341
      Introduction: Onychomycosis represents half of nail disorders seen in clinical practice. Despite its high prevalence, a bibliometric analysis has not been performed. We aimed to identify the top 100 highly cited onychomycosis publications over the last 50 years to better understand research trends.Methods: SCOPUS was searched for onychomycosis publications, using "onychomycosis" and "nail fungus" 1/1/1972-12/31/22 on 3/25/23. Top 100 highly cited publications were recorded and ranked by total citation count.
    Results: Total citation count was 13,456, with the top 10 articles with highest citation count/year having average 28.7 citations/year. Most articles were published in high IF journals. From 1982 to 2011 (no treatment articles - 1972-1981), there was an 8.6% increase in articles discussing treatment. Overall, 42% of first authors were female.
    Conclusion: We found an overall increase in articles discussing onychomycosis therapies over time, with the majority published in high IF journals. We also found a relatively greater percentage of female first authors compared to studies on other dermatologic topics. While total citation count remains a widely used metric of impact in bibliometric studies, average citation count/year may be a better measure of impact and should be considered in future studies.
    Keywords:  Bibliometric analysis; Citation; Impact factor; Nail fungus; Onychomycosis
    DOI:  https://doi.org/10.1159/000531184
  3. Front Neurosci. 2023 ;17 1265854
      Background: Electroacupuncture has been used as a treatment; however, a visual bibliometric analysis has not yet been performed in this field. In this study, we aimed to suggest future research topics and directions related to the field by examining the last 20 years of research trends and hotspots of electroacupuncture in stroke.Methods: We searched the Web of Science database on electroacupuncture as a treatment for stroke published from 2003 to 2022. We analyzed the papers by annual publication, research fields, nations, affiliations, authors, journals, and keywords. VOSviewer software was used to visualize the bibliometric analysis and results. A total of 440 papers were included in the analysis.
    Results: The number of publications has gradually increased every year, and neuroscience has become the most actively studied field. Neural Regeneration Research journal and China had the most publications. Fujian University of Traditional Chinese Medicine, as an affiliated institute, published the most articles. Chen Lidian and Tao Jing presented the largest number of papers, making them the leading contributors in this field. Four clusters were created by analyzing keywords, such as "neuroprotection," "clinical rehabilitation," "neuroplasticity," and "pretreatment-induced tolerance".
    Conclusion: This study is the first to analyze the research trends in electroacupuncture as a treatment for stroke using the VOSviewer. It shows the current state of research in the field by visualizing research trends and hotspots. This will help offer reference data for future studies.
    Keywords:  VOSviewer; Web of Science; bibliometric analysis; electroacupuncture; stroke
    DOI:  https://doi.org/10.3389/fnins.2023.1265854
  4. CNS Neurosci Ther. 2023 Oct 30.
      AIMS: Itch, a common uncomfortable sensory experience, occurs frequently in inflammatory or allergic disorders. In recent years, with the discovery of itch-specific pathways in the peripheral and central nervous system, the association between immunology and neural pathways has gradually emerged as the main mechanism of itch. Although many studies have been conducted on itch, no bibliometric analysis study focusing on this topic has been conducted. This study aimed to explore the research hotspots and trends in the itch field from a bibliometric perspective.METHODS: Publications relevant to itch, published from 2003 to 2022, were retrieved from the Science Citation Index-Expanded of Web of Science Core Collection. Publications were critically reviewed and analyzed with CiteSpace software, Vosviewer, and the bibliometric online analysis platform. Visual maps were conducted in terms of annual production, collaborating countries or institutions, productive authors, core journals, co-cited references, and keyword bursts.
    RESULTS: 2395 articles on itch that met our criteria were identified and the quantity of publications has been increasing rapidly since 2012. The USA was the most influential country. University Hospital Münster was the institution with the most publications. Gil Yosipovitch was the most prolific author. Atopic dermatitis (AD), intradermal serotonin, chronic pruritus, mechanical itch, gastrin-releasing peptide, substance p, interleukin-31 receptor, histamine-induced itch, bile acid, scratching behavior, and h-4 receptor were the top 11 clusters in co-citation cluster analysis. Keyword burst analysis suggested that treatment, inflammation, and AD are current research hotspots.
    CONCLUSION: Global publications on itch research have increased steadily and rapidly over the past 20 years. Inflammation and AD are current research hotspots. The neuroimmunological and neuroinflammatory mechanisms of itch, as well as clinical assessment methods and therapeutic targets, will be novel research directions in the future. This study provides guidance for further itch research.
    Keywords:  bibliometric analysis; inflammation; itch; neuroimmunology
    DOI:  https://doi.org/10.1111/cns.14514
  5. Hum Vaccin Immunother. 2023 Dec 15. 19(3): 2267301
      This study aimed to conduct a bibliometric analysis in the field of bladder cancer (BC) immunotherapy, and explore the research trends, hotspots and frontiers from 2000 to 2022. VOSviewer software was used to analyze the collaborative relationships between authors, institutions, countries/regions, and journals through citation, co-authorship, and co-citation analysis, to identify research hotspots and frontiers in this field. Researchers based in the United States of America have published a total of 627 papers with 27,308 citations. Indeed, the USA ranked first among the top 10 most active countries and showed the most extensive collaboration with other countries. The University of Texas MD Anderson CANC CTR has published 58 articles, making it the top most institution in terms of published articles and active collaborative research. Kamat AM and Lamm DL were the most active and co-cited authors with 28 papers and 980 co-citations, respectively. Chang Yuan and Xu le were the most active collaborative authors with a total link strength of 195. The J UROLOGY was the most active and frequently co-cited journal, with 100 papers and 6,668 co-citations. Studies of BC immunotherapy can be broadly classified into three categories: "basic research", "clinical trial", and "prognosis". Our findings provide an overview of the research priorities and future directions of BC immunotherapy. Tumor microenvironment and immune checkpoint inhibitors (ICIs) of BC, as well as the combination of ICIs with other drugs, may become the main direction of future research.
    Keywords:  Bibliometrics; bladder cancer; diagnosis; immunotherapy; prognosis
    DOI:  https://doi.org/10.1080/21645515.2023.2267301
  6. Int J Oral Maxillofac Implants. 2023 Nov 01. 0(0): 1-22
      Dental implants are an established treatment options for varying edentulous conditions and has grown in popularity since the 1990's. This increased clinical application has evidenced a parallel increase in dental implant related research. The objective of this paper was to perform a comprehensive bibliometric analysis of five dental implantology journals from 1991-2023.MATERIALS AND METHODS: We performed a search in the ISI Web of Science database between 1991 and 2023 in 5 journals with a focus on dental implantology: Clinical Oral Implant Research, Clinical Implant Dentistry and Related Research, Implant Dentistry, International Journal of Oral and Maxillofacial Implants, and International Journal of Oral Implantology. Results marked as correction, retraction notices, retracted articles, meeting abstract, withdrawn publications were removed from the analysis. The time period analyzed was divided into 4 decades: 1991-2000, 2001-2010, 2011-2020, 2021-2023. Additionally, the top 100 cited papers were also exported separately. Authors and countries with most publications were tabulated from the Web of Science database. VOS Viewer software was used to create network maps of keywords and title word occurrences for each of the time periods. Histcite software was used to analyze number of publications and citation counts.
    RESULTS: Network maps of keywords and title word occurrences suggested an early focus on osseointegration and titanium implants between 1991-2000. Publications between 2001-2010 saw a focus on in-vivo studies, implant surface and peri-implantitis. Publications post 2011 saw a focus on bone regeneration, complications and zygomatic implants. USA ranked highest in total number of publications in all time periods analyzed.
    CONCLUSIONS: Within the limitations of the study, we reported a comprehensive bibliometric analysis from 1990-2023. We identified trends in keywords and titles of dental implant publications in these journals which mirrored the trends seen in clinical practice.
    DOI:  https://doi.org/10.11607/jomi.10758
  7. Ann Med Surg (Lond). 2023 Nov;85(11): 5568-5576
      Background: A plethora of monkeypox papers have been published; however, pinpointing key and pivotal studies can be challenging amongst the ever-expanding literature. Bibliometric analyses are helpful in identifying the most influential articles and their impact pertinent to this field, which has helped mould the recognition and management of monkeypox.Methods: The Web of Science Core Collection (WoSCC) was searched on 27 October 2022. The top 100 most-cited articles on monkeypox were identified and evaluated by author, country, institution, type of articles, theme, journal of publication, keywords, and citations.
    Results: The top 100 most-cited studies were published between 1997 and 2022, and the 5-year period with the largest number of articles was 2007-2011. The median number of citations among the top 100 most-cited articles was 78.23. Of the top 100 most-cited studies, 91 were original articles, and nine were reviews, the median of annual citations was significantly higher in the review group than the original group, 7.86 (4.20-13.80) versus 4.50 (3.07-7.59; P=0.023). The 100 articles were classified into different research theme, with the top three being Immunology (31%), Infectious Diseases (30%), and Virology (26%), respectively. The keywords with the highest co-occurrence frequency were "monkeypox", "smallpox," and "smallpox virus." The largest number of articles in the top 100 were published in Emerging Infectious Diseases (n=13), followed by Journal of Virology (n=11), Journal of Infectious Diseases (n=5), and PLoS One (n=5). The authors identified 711 different authors from 195 institutions and 28 countries in the top 100 most-cited articles, with the majority based in the USA.
    Conclusion: The top 100 most-cited studies provide an important insight into the historical developments of monkeypox. The authors should strengthen the recognition and management of monkeypox worldwide and strengthen research cooperation among scholars in order to better respond to the ongoing or future outbreak.
    Keywords:  bibliometric analysis; management; monkeypox; recognition; top 100 most cited
    DOI:  https://doi.org/10.1097/MS9.0000000000001367
  8. Heliyon. 2023 Nov;9(11): e21300
      Background: Infantile hemangioma (IH) has received global attention, resulting in a significant volume of literature. However, there is a lack of bibliometric analyses specifically focusing on IH publications. This study aims to fill this gap by conducting a comprehensive analysis of IH publications, investigating their characteristics, contribution distribution, and developmental trends. By enhancing our understanding of IH and identifying potential research topics and collaborators, this study will contribute to the advancement of the field.Methods: A total of 4333 articles and reviews on IH were collected from the Web of Science (WoS) database, spanning the years 2000-2022. The study encompassed a comprehensive analysis of IH publications, evaluating their quantity and quality. Additionally, we profiled publishing groups based on country, institution, author publication records, and collaboration networks. Lastly, we identified and summarized the prominent research topics.
    Results: Annual publications on IH have increased over the past 20 years. The United States has the highest number of publications and the highest total number of citations. Pediatric Dermatology was the most influential journal in the IH field. The citation analysis indicated that the articles published by Léauté-Labrèze in 2008 had the highest number of citations. The articles published by North PE in 2000 and Boye E in 2001 laid a certain research foundation for this field. Concerning institutions, most of the cooperative relationships were established in the same country/region. The United States has the largest number of scientific research institutions and IH researchers, leading most of the cross-country collaboration. The University of California, San Francisco, Medical College of Wisconsin, Harvard University, and Shanghai Jiaotong University were the research centers that published the most IH-related research. Frieden IJ, Mulliken JB, and Drolet BA were the top three most influential authors. Frieden IJ, Garzon MC, and Mulliken JB were the top three authors with the most cited frequency. In addition, keywords and keyword co-occurrence networks prompted that the pathological mechanism of IH, clinical analysis, and other vascular anomalies are research hotspots. Analysis of trending topics suggests that research on IH has evolved from treatment-focused studies towards investigations of other vascular diseases and a series of clinical case studies. Currently, clinical case studies receive the most attention in the field.
    Conclusions: This comprehensive bibliometric study provides a thorough analysis of post-2000 publications in the field of IH, offering insights into current research trends for the first time. The findings suggest that future investigations will continue to prioritize understanding IH mechanisms, treatment approaches, and treatment evaluation. Furthermore, the exploration of other vascular diseases and the inclusion of clinical case studies are expected to contribute to advancements in IH clinical practice. By identifying potential collaborators, partner institutions, and new research avenues, this study offers valuable guidance for future in-depth research on IH.
    Keywords:  Bibliometric analysis; Biblioshiny; Infantile hemangioma; Propranolol; Vascular anomalies; Web of science
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e21300
  9. Electrophoresis. 2023 Nov 01.
      To gain a deeper understanding of the current status of research on Traditional Chinese Medicine (TCM) and nanoparticles, we conducted a bibliometric study. We conducted a literature search in the Web of Science (WOS) for publications related to TCM and nanoparticles from 1992 to 2023. The data, including countries of publication, research institutions, journals, citations, and keywords, were analyzed using the Bibliometrix R-4.0 software package. We performed an analysis to identify the co-occurrence of keywords in the documents including their titles and abstracts. From 2005 to 2023, a total of 309 publications were included, with an average annual growth rate of 4.25%. The majority of these publications were published in Q1 journals (72, 47.06%) and Q2 journals (45, 29.41%). Among the 309 publications, 22 articles (7.12%) had an impact factor greater than 10, while 78 articles (25.24%) had an impact factor greater than 5. The analysis of international collaboration networks revealed limited international cooperation, with most collaborations occurring between institutions in China, the United States, and Australia. These 309 publications involved a total of 438 research institutions, with Chinese research institutions being the most prolific contributors. In this study, a total of 309 publications were included, comprising 1142 author keywords and 1175 keywords plus. Factor analysis of the 1175 keywords plus revealed that they could be grouped into five categories: one category included terms such as "oxide" and "zinc," another category included terms like "lipid" and "acid," a third category included terms such as "improve" and "enhance," a fourth category included terms like "silica" and "mesoporous," and the fifth category included terms like "PLGA" and "immune." Research on nanoparticles in TCM has been gradually gaining popularity. Currently, most of the research in this field is conducted in China, with limited international collaboration. The majority of TCM nanoparticle research focuses on individual herbal compounds, while research on nanoparticle formulations of traditional herbal prescriptions is relatively scarce.
    Keywords:  Traditional Chinese Medicine; bibliometric analysis; nanoparticles
    DOI:  https://doi.org/10.1002/elps.202300207
  10. Curr Med Imaging. 2023 Oct 25.
      BACKGROUND: Lung ultrasound (LUS) is gaining recognition as an indispensable diagnostic tool in critical care.OBJECTIVE: The study aimed to characterize the global research landscape and trend of LUS with quantification and visualization approaches.
    METHODS: Documents related to LUS published between 2007 and 2023 were selected from the Web of Science Core Collection and identified. Visualization and statistical analysis were conducted with the VOSviewer 1.6.18, CiteSpace 5.7.R5, and Bibliometrix 4.1.0 Package, including analysis of the trend of global publications, prominent countries, active institutions, and funding agencies, key authors and journals, co-cited references, and keywords.
    RESULTS: A total of 3010 publications, including 2434 articles and 576 reviews, were retrieved. The output of LUS-related research has increased steadily over the years, especially after 2018. Italy (n=756; 25.12%) has shown the highest output, being the country with the highest total citations (23423 times). The most influential author was Gargani Luna with 52 documents, who worked at the Consiglio Nazionale delle Ricerche. Chest and Intensive Care Medicine with high citations and impact factor scores were the most influential journals. Besides "lung ultrasonography", the keywords developed included "coronavirus disease 2019 (COVID-19)", "acute respiratory distress syndrome", and "acute heart failure".
    CONCLUSION: Research output on LUS has increased steadily, especially after 2018. Italy and the United States are staying ahead in this field. Research collaboration still needs to be strengthened. This comprehensive analysis has presented the global research landscape and trends of LUS-related research, providing valuable information for researchers to pursue further exploration.
    Keywords:  Bibliometric analysis; COVID-19; Lung ultrasound; Medical imaging; Pneumonia; Ultrasonography
    DOI:  https://doi.org/10.2174/0115734056262197231019113741
  11. Front Neurol. 2023 ;14 1284501
      This bibliometric study aimed to summarize and visualize the current research status, emerging trends, and research hotspots of regulatory T (Treg) cells in neurological diseases. Relevant documents were retrieved from the Web of Science Core Collection. Tableau Public, VOSviewer, and CiteSpace software were used to perform bibliometric analysis and network visualization. A total of 2,739 documents were included, and research on Treg cells in neurological diseases is still in a prolific period. The documents included in the research were sourced from 85 countries/regions, with the majority of them originating from the United States, and 2,811 organizations, with a significant proportion of them coming from Harvard Medical School. Howard E Gendelman was the most prolific author in this research area. Considering the number of documents and citations, impact factors, and JCR partitions, Frontiers in Immunology was the most popular journal in this research area. Keywords "multiple sclerosis," "inflammation," "regulatory T cells," "neuroinflammation," "autoimmunity," "cytokines," and "immunomodulation" were identified as high-frequency keywords. Additionally, "gut microbiota" has recently emerged as a new topic of interest. The study of Treg cells in neurological diseases continues to be a hot topic. Immunomodulation, gut microbiota, and cytokines represent the current research hotspots and frontiers in this field. Treg cell-based immunomodulatory approaches have shown immense potential in the treatment of neurological diseases. Modifying gut microbiota or regulating cytokines to boost the numbers and functions of Treg cells represents a promising therapeutic strategy for neurological diseases.
    Keywords:  bibliometric analysis; cytokines; gut microbiota; immunomodulation; neurological diseases; regulatory T cells
    DOI:  https://doi.org/10.3389/fneur.2023.1284501
  12. Front Neurol. 2023 ;14 1268639
      Background: Obstructive sleep apnea (OSA) is a type of sleep-disordered breathing disease, with high prevalence and multiple complications. It seriously affects patients' quality of life and even threatens their lives. Early and effective treatment can significantly improve patients' health conditions.Objective: In this study, the main treatment methods, research hotspots and trends of OSA were summarized through bibliometric and visualization analysis.
    Methods: From the Web of Science Core Collection database, articles on the treatment of OSA from 1999 to 2022 were obtained. CiteSpace and VOSviewer were comprehensively used to visualization of journals, co-authorship of countries, institutions and authors, co-citation of references, keywords cluster and burst.
    Results: A total of 2,874 publications were obtained, of which 2,584 were concerned adults and 290 about children. In adults' research, Sleep and Breathing is the most published journal (280, 10.84%), the largest number of publications come from the United States (636,24.61%) and the University of Sydney (88, 3.41%), and Pepin JL is the most published author (48, 18.58%). In children's studies, International Journal of Pediatric Otorhinolaryngology is the most published journal (41, 14.14%), the maximum number of publications were also from the United States (123, 42.41%), with the University of Pennsylvania (20, 6.90%) and Marcus CL (15, 5.17%) being the most published institutions and authors. High-frequency keywords for adults' researches include positive airway pressure, oral appliance, surgery and positional therapy. On these basis, children's studies also focus on myofunctional therapy, rapid maxillary expansion and hypoglossal nerve Stimulation.
    Conclusion: Over the past two decades, research in the field of OSA therapeutics has experienced significant growth in depth and breadth. The author cooperation network has already established a solid foundation, while there is potential for further strengthening the cooperation network between countries and institutions. Currently, positive airway pressure and surgery are the primary treatments for OSA in adults and children. Future research will focus on multidisciplinary combination targeted therapy, which presents a key area of interest and challenge.
    Keywords:  OSA; bibliometric analysis; hotspots; obstructive sleep apnea; therapy
    DOI:  https://doi.org/10.3389/fneur.2023.1268639
  13. World Neurosurg. 2023 Oct 26. pii: S1878-8750(23)01523-1. [Epub ahead of print]
      OBJECTIVE: To conduct a quantitative analysis of published studies on hematoma enlargement after intracerebral hemorrhage.MATERIALS AND METHODS: Studies on hematoma enlargement after cerebral hemorrhage were retrieved from the Web of Science database on June 30, 2023. Microsoft Excel, VOSviewer, and CiteSpace software were used for bibliometric analysis and visualization, focusing on the quantitative characteristics of the literature.
    RESULT: A total of 444 articles were published in 161 journals, with 2161 authors from 41 countries and 717 institutions. The most published authors, countries, and institutions were Goldstein, the USA, and Massachusetts General Hospital. Stroke published the most studies, but the average citation number per year of Lancet Neurology far exceeded that of other journals. The research field of hematoma enlargement is mainly divided into three focuses, including mechanisms, identification (computed tomography signs, predictive models), and treatment (hemostasis, antihypertensive therapy). Most bursts in publication number have been since 2010, where the highest burst was from research on spot signs, and the latest burst focused on tranexamic acid. Treatment using tranexamic acid based on different computed tomography signs is a focus of current research, but the effectiveness still requires further exploration.
    CONCLUSION: This bibliometric analysis analyzed the research framework and hotspots on hematoma enlargement after cerebral hemorrhage, which can help researchers better understand this field and provide potential suggestions for collaborations and research.
    Keywords:  bibliometric analysis; cerebral hemorrhage; hematoma enlargement; hematoma expansion; intracerebral hemorrhage; treatment
    DOI:  https://doi.org/10.1016/j.wneu.2023.10.117
  14. Hum Vaccin Immunother. 2023 Dec 15. 19(3): 2266926
      Atherosclerosis (AS) is a prevalent cardiovascular disease that greatly increases mortality in the aging population and imposes a heavy burden on global healthcare systems. The purpose of this study is to examine the research structure and current trends of monoclonal antibodies (mAbs) against AS from a bibliometric perspective, since the development of these drugs is currently booming. This study collected articles and reviews on mAbs against AS from the Web of Science Core Collection, spanning from 2003 to 2022. Biblioshiny was utilized to analyze and visualize the characteristics of countries, regions, authors, institutions, and journals included in this collection. We used VOS viewer to illustrate the frequency of country co-occurrence, and CiteSpace to visualize co-cited reference, keywords co-occurrence, keywords citation bursts, keywords clustering and timeline plots. The study included 1325 publications, with the United States emerging as a leading contributor to the field. ATHEROSCLEROSIS, CIRCULATION and ARTERIOSCLEROSISTHROMBOSIS AND VASCULAR BIOLOGY are core journals that publish high-quality literature on the latest advances in the field. Noteworthy authors with numerous high-quality publications include Witztum JL and Tsimikas S. Currently, lipid metabolism and inflammation are the main research areas of interest in this field. The mAbs against AS is an evolving field, and ongoing research continues to advance our understanding. This paper provides a comprehensive overview of the current state of knowledge in this area, highlighting two primary research directions: inflammation and lipid metabolism. Additionally, the paper identifies emerging research hotspots, which will provide researchers with useful insights to guide future investigations and anticipate research directions.
    Keywords:  CiteSpace; Monoclonal antibodies; atherosclerosis; bibliometrics; mabs
    DOI:  https://doi.org/10.1080/21645515.2023.2266926
  15. Front Oncol. 2023 ;13 1274290
      Objective: The purpose of this scoping review was to explore the top 100 most cited articles in helical tomotherapy (HT) through bibliometric analysis and visualization tools, help researchers comprehensively understand the research hotspots of HT, and provide clear and intuitive network visualization.Methods: The Web of Science Core Collection and the search strategy of "Title (TI)=(tomotherapy)" were used to search for articles related to HT as of 27 May 2023. The top 100 most cited articles were obtained by sorting "citations: highest first". From these top 100 most cited articles, the following information was extracted: journals, years and months, countries, authors, types of tumor treated, and topics. The VOSviewer software was introduced for visualizing all the articles related to HT.
    Results: The top 100 most cited articles in HT were published between 1999 and 2019. The citation counts of these articles ranges from 326 to 45, with a total of 8,422 citations at the time of searching. The index of citations per year (CPY) ranges from 22.32 to 2.45. These articles originated from 17 countries, with most publications from the United States (n=50), followed by Canada (n=12), Italy (n=10), Germany (n=7) and Belgium (n=5). The International Journal of Radiation Oncology, Biology, Physics published the highest number of articles (n=31), followed by Radiotherapy and Oncology (n=20), Medical Physics (n=13) and Strahlentherapie und Onkologie (n=12). In terms of specific tumor types, head and neck cancer (n=15) is the most common disease, followed by cancers with complex target structures (n=14), breast cancer (n=12), prostate cancer (n=10) and lung cancer (n=8). The most common research topics also include dosimetric comparison (n = 44), quality assurance (n = 12) and Megavoltage CT (n = 8).
    Conclusion: This scoping review provides a comprehensive list of the 100 most cited articles in HT. This analysis offers valuable insights into the current research directions of HT that can be utilized by researchers, clinicians, and policy-makers.
    Keywords:  helical tomotherapy; most cited articles; network visualization; research trends; scoping review
    DOI:  https://doi.org/10.3389/fonc.2023.1274290
  16. World J Gastroenterol. 2023 Oct 07. 29(37): 5339-5360
      BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is chronic, with its progression leading to liver fibrosis and end-stage cirrhosis. Although NAFLD is increasingly common, no treatment guideline has been established. Many mechanistic studies and drug trials have been conducted for new drug development to treat NAFLD. An up-to-date overview on the knowledge structure of NAFLD through bibliometrics, focusing on research hotspots, is necessary to reveal the rational and timely directions of development in this field.AIM: To research the latest literature and determine the current trends in treatment for NAFLD.
    METHODS: Publications related to treatment for NAFLD were searched on the Web of Science Core Collection database, from 2010 to 2023. VOSviewers, CiteSpace, and R package "bibliometrix" were used to conduct this bibliometric analysis. The key information was extracted, and the results of the cluster analysis were based on network data for generating and investigating maps for country, institution, journal, and author. Historiography analysis, bursts and cluster analysis, co-occurrence analysis, and trend topic revealed the knowledge structure and research hotspots in this field. GraphPad Prism 9.5.1.733 and Microsoft Office Excel 2019 were used for data analysis and visualization.
    RESULTS: In total, 10829 articles from 120 countries (led by China and the United States) and 8785 institutions were included. The number of publications related to treatment for NAFLD increased annually. While China produced the most publications, the United States was the most cited country, and the United Kingdom collaborated the most from an international standpoint. The University of California-San Diego, Shanghai Jiao Tong University, and Shanghai University of Traditional Chinese Medicine produced the most publications of all the research institutions. The International Journal of Molecular Sciences was the most frequent journal out of the 1523 total journals, and Hepatology was the most cited and co-cited journal. Sanyal AJ was the most cited author, the most co-cited author was Younossi ZM, and the most influential author was Loomba R. The most studied topics included the epidemiology and mechanism of NAFLD, the development of accurate diagnosis, the precise management of patients with NAFLD, and the associated metabolic comorbidities. The major cluster topics were "emerging drug," "glucagon-like peptide-1 receptor agonist," "metabolic dysfunction-associated fatty liver disease," "gut microbiota," and "glucose metabolism."
    CONCLUSION: The bibliometric study identified recent research frontiers and hot directions, which can provide a valuable reference for scholars researching treatments for NAFLD.
    Keywords:  Bibliometrics; Historiography analysis; Metabolic dysfunction-associated fatty liver disease; Nonalcoholic fatty liver disease; Therapy; Treatment
    DOI:  https://doi.org/10.3748/wjg.v29.i37.5339
  17. Blood Purif. 2023 Oct 31.
      Background Liver failure is a life-threatening condition characterized by the accumulation of metabolic toxins. Extracorporeal albumin dialysis (ECAD) has been promoted as a possible therapy. Methods We employed bibliometric analysis to scrutinize the conceptual, intellectual, and social structure of the ECAD literature including its co-citation network and thematic analysis to explore its evolution and organization. Results We identified 784 documents with a mean of 30.25 citations per document in a corpus of 15,191 references. The average citation rate peaked in 1998 at 280.75 citations/year before a second 2013 peak of 54.81 citations/year and then progressively decreased to its nadir in 2022 (1.48 yearly citations). We identified four primary co-citation clusters, with the most impactful publications being small "positive" manuscripts by Mitzner et al (2000) and Heemann et al. (2002) (Cluster 1). This first cluster had several relational citations with clusters 2 and 3, but almost no citation link with cluster 4 represented by Banares et al. (2013), Saliba et al. (2013), and Larsen et al. (2016), with their three negative randomized controlled trials. Finally, the thematic map revealed a shift in focus over time, with inflammation and ammonia as recent emergent themes. Conclusions This bibliometric analysis provided a transparent and reproducible longitudinal assessment of ECAD literature and demonstrated how positive studies with low levels of evidence can dominate a research field and overshadow negative findings from higher-quality studies. These insights hold significant implications for future research and clinical practice within this domain.
    DOI:  https://doi.org/10.1159/000534915
  18. Front Oncol. 2023 ;13 1222426
      Objective: Artificial intelligence (AI), with its potential to diagnose skin cancer, has the potential to revolutionize future medical and dermatological practices. However, the current knowledge regarding the utilization of AI in skin cancer diagnosis remains somewhat limited, necessitating further research. This study employs visual bibliometric analysis to consolidate and present insights into the evolution and deployment of AI in the context of skin cancer. Through this analysis, we aim to shed light on the research developments, focal areas of interest, and emerging trends within AI and its application to skin cancer diagnosis.Methods: On July 14, 2023, articles and reviews about the application of AI in skin cancer, spanning the years from 1900 to 2023, were selected from the Web of Science Core Collection. Co-authorship, co-citation, and co-occurrence analyses of countries, institutions, authors, references, and keywords within this field were conducted using a combination of tools, including CiteSpace V (version 6.2. R3), VOSviewer (version 1.6.18), SCImago, Microsoft Excel 2019, and R 4.2.3.
    Results: A total of 512 papers matching the search terms and inclusion/exclusion criteria were published between 1991 and 2023. The United States leads in publications with 149, followed by India with 61. Germany holds eight positions among the top 10 institutions, while the United States has two. The most prevalent journals cited were Cancer, the European Journal of Cancer, and Sensors. The most frequently cited keywords include "skin cancer", "classification", "artificial intelligence", and "deep learning".
    Conclusions: Research into the application of AI in skin cancer is rapidly expanding, and an increasing number of scholars are dedicating their efforts to this field. With the advancement of AI technology, new opportunities have arisen to enhance the accuracy of skin imaging diagnosis, treatment based on big data, and prognosis prediction. However, at present, the majority of AI research in the field of skin cancer diagnosis is still in the feasibility study stage. It has not yet made significant progress toward practical implementation in clinical settings. To make substantial strides in this field, there is a need to enhance collaboration between countries and institutions. Despite the potential benefits of AI in skin cancer research, numerous challenges remain to be addressed, including developing robust algorithms, resolving data quality issues, and enhancing results interpretability. Consequently, sustained efforts are essential to surmount these obstacles and facilitate the practical application of AI in skin cancer research.
    Keywords:  CiteSpace; VOSviewer; artificial intelligence; bibliometric; skin cancer
    DOI:  https://doi.org/10.3389/fonc.2023.1222426
  19. Front Oncol. 2023 ;13 1170464
      Background: The sentinel lymph node biopsy (SLNB) takes on a critical significance in breast cancer surgery since it is the gold standard for assessing axillary lymph node (ALN) metastasis and determining whether to perform axillary lymph node dissection (ALND). A bibliometric analysis is beneficial to visualize characteristics and hotspots in the field of sentinel lymph nodes (SLNs), and it is conducive to summarizing the important themes in the field to provide more insights into SLNs and facilitate the management of SLNs.Materials and methods: Search terms relating to SLNs were aggregated and searched in the Web of Science core collection database to identify the top 100 most cited articles. Bibliometric tools were employed to identify and analyze publications for annual article volume, authors, countries, institutions, keywords, as well as hotspot topics.
    Results: The period was from 1998 to 2018. The total number of citations ranged from 160 to 1925. LANCET ONCOLOGY and JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION were the top two journals in which the above articles were published. Giuliano, AE was the author with the highest number of articles in this field with 15. EUROPEAN INST ONCOL is the institution with the highest number of publications, with 35 articles. Hotspots include the following 4 topics, false-negative SLNs after neoadjuvant chemotherapy; prediction of metastatic SLNs; quality of life and postoperative complications; and lymphography of SLNs.
    Conclusion: This study applies bibliometric tools to analyze the most influential literature, the top 100 cited articles in the field of SLNB, to provide researchers and physicians with research priorities and hotspots.
    Keywords:  bibliometric; biopsy; breast cancer; sentinel lymph node; trends
    DOI:  https://doi.org/10.3389/fonc.2023.1170464
  20. Eur Rev Med Pharmacol Sci. 2023 Oct;pii: 34122. [Epub ahead of print]27(20): 9478-9498
      OBJECTIVE: Transient receptor potential (TRP) channels are a superfamily of permeable cation channels activated by various mechanisms and play a role in nearly all types of sensory signal transduction. In academia, few have comprehensively discussed the research status of TRP channels. This study aims to summarize the knowledge structure and research hotspots of TRP channels using bibliometrics.MATERIALS AND METHODS: TRP channel-related publications from 2003 to 2022 were searched in the Web of Science Core Collection (WoSCC) database. VOSviewer was used for the bibliometric analysis of the literature.
    RESULTS: We included 12,242 articles from 102 countries, primarily from the United States, China, and Japan. Our research indicates that the number of publications related to TRP channels has increased annually from 2003 to 2022. The leading research institutions are KU Leuven, Harvard University, and the Chinese University of Hong Kong. The Journal of Biological Chemistry is the foremost in this field. The main research topics include the structure and function of TRP channels, their role in pathogenesis, and potential therapeutic strategies for diseases such as pain and respiratory diseases. Among these, "transient receptor potential vanilloid 1 (TRPV1)", "transient receptor potential ankyrin 1 (TRPA1)", "TRPV4", "pain", and "therapy" are emerging research hotspots.
    CONCLUSIONS: This study offers a comprehensive summary of the current research status and development trends of TRP channels and pinpoints the research hotspots in this field. It not only aids individuals interested in TRP channel-related research in quickly gauging the trends but may also guide the future research directions of researchers.
    DOI:  https://doi.org/10.26355/eurrev_202310_34122
  21. Intern Emerg Med. 2023 Nov 03.
      Quantitative bibliometric indicators are widely used and widely misused for research assessments. Some metrics have acquired major importance in shaping and rewarding the careers of millions of scientists. Given their perceived prestige, they may be widely gamed in the current "publish or perish" or "get cited or perish" environment. This review examines several gaming practices, including authorship-based, citation-based, editorial-based, and journal-based gaming as well as gaming with outright fabrication. Different patterns are discussed, including massive authorship of papers without meriting credit (gift authorship), team work with over-attribution of authorship to too many people (salami slicing of credit), massive self-citations, citation farms, H-index gaming, journalistic (editorial) nepotism, journal impact factor gaming, paper mills and spurious content papers, and spurious massive publications for studies with demanding designs. For all of those gaming practices, quantitative metrics and analyses may be able to help in their detection and in placing them into perspective. A portfolio of quantitative metrics may also include indicators of best research practices (e.g., data sharing, code sharing, protocol registration, and replications) and poor research practices (e.g., signs of image manipulation). Rigorous, reproducible, transparent quantitative metrics that also inform about gaming may strengthen the legacy and practices of quantitative appraisals of scientific work.
    Keywords:  Bibliometrics; Citations; Fraud; Gaming; Gift authorship; Impact factor; Research assessment; Self-citations
    DOI:  https://doi.org/10.1007/s11739-023-03447-w
  22. Medicine (Baltimore). 2023 Oct 27. 102(43): e35599
      BACKGROUND: The number of patients undergoing percutaneous coronary intervention (PCI) procedures is increasing along with the number of studies involving guidelines, prognostic assessments, and cardiac rehabilitation related to PCI strategies. However, fewer studies have reported the mapping of knowledge structure and hotspot analysis in this field. Our goal was to discuss and analyze the current status, hot spots and developmental trends associated with research into the prognosis of patients undergoing PCI, and to provide reference for PCI-related research.METHODS: The Web of Science Core Collection and China Knowledge Network were searched for relevant literature from January 2003 to October 2022, and CiteSpace 6.1. R3 software was used to analyze the co-occurrence, clustering, and emerging authors, institutions, and keywords.
    RESULTS: A total of 2666 English and 2010 Chinese publications were included. The number of publications showed a growing trend. The author with the maximum number of articles was Xu Bo. The institutions with high productivity were Peking Union Medical College and Capital Medical University. Although the number of Chinese articles was high, the cooperation between institutions was low and the impact was small. The results of the analysis suggest a shift in the focus of keywords from coronary artery disease and PCI to studies involving the assessment and intervention of risk factors associated with poor prognosis of PCI. Traditional Chinese Medicine and anxiety represent the emerging direction of PCI prognosis. The assessment of major adverse cardiovascular events and cardiac rehabilitation require careful analysis in post-PCI research.
    CONCLUSION: The findings of this bibliometric study present a comprehensive and systematic overview of the PCI prognosis, based on the analysis of the current status and trends in research, which may facilitate the identification of hot topics and new directions for future research.
    DOI:  https://doi.org/10.1097/MD.0000000000035599
  23. Front Nutr. 2023 ;10 1253803
      Background: Cardiovascular diseases persist as the primary cause of mortality in the global population. Hypertension (HTN) is widely recognized as one of the most crucial risk factors contributing to severe cardiovascular conditions. In recent years, a growing body of research has highlighted the therapeutic potential of gut microbiota (GM) in addressing cardiovascular diseases, particularly HTN. Consequently, unraveling and synthesizing the connections between GM and HTN, key research domains, and the underlying interaction mechanisms have grown increasingly vital.Methods: We retrieved articles related to GM and HTN from 2014 to 2023 using Web of Science. Bibliometric tools employed in this analysis include CiteSpace and VOSviewer.
    Result: From 2014 to 2023, we identified 1,730 related articles. These articles involved 88 countries (regions) and 9,573 authors. The articles were published in 593 journals, with 1000 references exhibiting co-occurrence more than 10 times. The number of studies in this field has been increasing, indicating that it remains a research hotspot. We expect this field to continue gaining attention in the future. China leads in the number of published articles, while the United States boasts the most extensive international collaborations, signifying its continued prominence as a research hub in this domain. Tain You-Lin, Hsu Chien-Ning, Raizada Mohan K, and Yang Tao are among the authors with the highest publication volume. Publications in this field are frequently found in nutrition, cardiovascular, and molecular biology journals. The most frequently occurring keywords include metabolic syndrome, cardiovascular disease, inflammation, short-chain fatty acids, trimethylamine N-oxide, chronic kidney disease, heart failure, and high-salt diet.
    Conclusion: The relationship between GM and HTN is presently one of the most active research areas. By employing bibliometric tools, we analyzed critical and innovative articles in this field to provide an objective summary of the primary research directions, such as the relationship between GM and HTN, GM metabolites, high-salt diet, the developmental origins of health and disease, obstructive sleep apnea-Induced hypertension and antihypertensive peptide. Our analysis aims to offer researchers insights into hotspots and emerging trends in the field of GM and HTN for future research reference.
    Keywords:  bibliometrics; gut microbiota; hypertension; salt-sensitive hypertension; short-chain fatty acids
    DOI:  https://doi.org/10.3389/fnut.2023.1253803
  24. J Pain Res. 2023 ;16 3613-3624
      Purpose: The global incidence of primary dysmenorrhea is continuously increasing, and understanding its research trends is crucial for effective pain management and women's health. Therefore, this study aims to perform a comprehensive bibliometric analysis of primary dysmenorrhea research to identify hotspots, explore emerging trends, and provide valuable insights for future research endeavors.Material and Methods: All of the relevant studies on primary dysmenorrhea in the Web of Science™ Core Collection database were searched for bibliometric analysis. Biclustering analysis using gCLUTO software was performed to identify research hotspots. Social network analysis with Ucinet was employed to reveal knowledge structure. Evolutionary analysis using SciMAT was utilized to predict thematic trends.
    Results: A total of 903 papers were analyzed, indicating a gradual increase in research on primary dysmenorrhea in recent years, with the scope of research expanding and diversifying. We identified seven hotspots, three treatment nodes, and four thematic trends. Research hotspots focused on epidemiological studies, adolescent primary dysmenorrhea, drug and non-drug treatments. Within the realm of treatments, we have identified three treatment nodes: acupuncture, acupressure, and ibuprofen. The evolution of research has witnessed a shift from traditional epidemiological studies toward a more diverse research landscape. Adolescent primary dysmenorrhea is expected to remain a prominent research topic while dietary supplements and lifestyle are predicted to gain more attention. An emerging theme is the study of variation and polymorphism of circadian rhythm genes concerning primary dysmenorrhea.
    Conclusion: This bibliometric analysis provides valuable insights into the current state of research on primary dysmenorrhea, offering a clearer understanding of the field's landscape. The identified hotspots, knowledge structure, and thematic trends can serve as valuable references for future investigations in this area. The research holds significant scientific importance and innovative value in elucidating the mechanisms of primary dysmenorrhea and finding more effective treatment approaches.
    Keywords:  bibliometric analysis; pain management; primary dysmenorrhea; women’s health
    DOI:  https://doi.org/10.2147/JPR.S435236
  25. Medicine (Baltimore). 2023 Oct 27. 102(43): e35564
      BACKGROUND: Machine learning (ML) and artificial intelligence (AI) techniques are gaining popularity as effective tools for coronavirus disease of 2019 (COVID-19) research. These strategies can be used in diagnosis, prognosis, therapy, and public health management. Bibliometric analysis quantifies the quality and impact of scholarly publications. ML in COVID-19 research is the focus of this bibliometric analysis.METHODS: A comprehensive literature study found ML-based COVID-19 research. Web of Science (WoS) was used for the study. The searches included "machine learning," "artificial intelligence," and COVID-19. To find all relevant studies, 2 reviewers searched independently. The network visualization was analyzed using VOSviewer 1.6.19.
    RESULTS: In the WoS Core, the average citation count was 13.6 ± 41.3. The main research areas were computer science, engineering, and science and technology. According to document count, Tao Huang wrote 14 studies, Fadi Al-Turjman wrote 11, and Imran Ashraf wrote 11. The US, China, and India produced the most studies and citations. The most prolific research institutions were Harvard Medical School, Huazhong University of Science and Technology, and King Abdulaziz University. In contrast, Nankai University, Oxford, and Imperial College London were the most mentioned organizations, reflecting their significant research contributions. First, "Covid-19" appeared 1983 times, followed by "machine learning" and "deep learning." The US Department of Health and Human Services funded this topic most heavily. Huang Tao, Feng Kaiyan, and Ashraf Imran pioneered bibliographic coupling.
    CONCLUSION: This study provides useful insights for academics and clinicians studying COVID-19 using ML. Through bibliometric data analysis, scholars can learn about highly recognized and productive authors and countries, as well as the publications with the most citations and keywords. New data and methodologies from the pandemic are expected to advance ML and AI modeling. It is crucial to recognize that these studies will pioneer this subject.
    DOI:  https://doi.org/10.1097/MD.0000000000035564
  26. Medicine (Baltimore). 2023 Oct 27. 102(43): e35626
      Pediatric anesthesia is one of the most concerning topics in our society. However, there is still a lack of a comprehensive overview of the research base and of future trends. This study aimed to guide beginners quickly learn the academic research on pediatric anesthesia and do their own studies by analyzing the articles of this field in the latest 21 years through bibliometric analysis. Literature scanning was conducted with the Web of Science database. Microsoft Excel, SPSS, VOSviewer, and CiteSpace were in this review. There was an increasing trend of articles on pediatric anesthesia, based on the analysis of 11,591 included articles. The top 3 most productive countries were the United States of America (4538), Canada (730) and Turkey (688). The most productive institutions were Boston Childrens hospital, Childrens Hospital Philadelphia and Ohio State University. Tobias, Joseph D (141), Kim, Hee-Soo (40) and Curley, Martha A Q (38) were the most active authors. Habre W (2017), Gross JB (2002) and Cravero JP (2009) are the articles cited more than 100 times during the analysis years. Anesthesia and Analgesia, Anesthesiology, Pediatric Anesthesia, were the core journals in this field. Cohort, simulation, sleep, postoperative complication are strongest burst keywords in recent years. This article summarizes the authoritative institutions, authors, literatures and frontier hotspots on pediatric anesthesia. Itwill be a valuable literature review and help beginners to quickly get started in the field, reduce unnecessary clueless and aimless learning, and greatly improve learning efficiency.
    DOI:  https://doi.org/10.1097/MD.0000000000035626
  27. Transplantation. 2023 Nov 02.
      BACKGROUND: In the United States, only 13% of transplant surgeons are women. We evaluated gender distribution and trends of American authorship over the past 10 y in high-impact solid organ transplantation journals to gain insight into the current status of women authorship in transplantation.METHODS: Original articles from 2012 to 2021 from the 5 highest-impact solid organ transplantation journals were extracted from Scopus. First and last author's gender was predicted using Genderize.io. Data of first and last authors, article type and topic, location, citation, and funding metrics were analyzed. Chi-square, logistic regression, and trend tests were performed where appropriate. Statistical significance was set at <0.05.
    RESULTS: Women's first and last authorship increased over time among all journals. There was an increase in women first authors in the American Journal of Transplantation and in senior women authors in Liver Transplantation and Transplantation. Significant differences in gender authorship in lung, intestine, pancreas, general, and islet cell transplantation were found. Women's last authorship was associated with 1.69 higher odds of having a woman first author when adjusting for year and journal. There was an increase in the rate of women's first and last author collaborations over the years. Women last authors had 1.5 higher odds of being funded by the National Institutes of Health over the years.
    CONCLUSIONS: Despite an increase in women transplant surgeons and physicians, the gap in women authorship in transplantation persists. Women's last authorship was associated with higher odds of having a woman first author, pointing to the importance of mentorship for women joining the transplant academia.
    DOI:  https://doi.org/10.1097/TP.0000000000004844
  28. World J Gastroenterol. 2023 Sep 28. 29(36): 5254-5267
      BACKGROUND: Barrier surfaces composed of specialized epithelial cells separate the host body from the external environment, and are essential for maintaining proper intestinal physiologic and immune homeostasis.AIM: To explore the development trends and research hotspots of intestinal barrier research in inflammatory bowel disease (IBD).
    METHODS: The publications related to the intestinal barrier in IBD were obtained from the Web of Science Core Collection database. Bibliometric analysis and visualization were conducted using VOSviewer, CiteSpace and R software.
    RESULTS: A total of 4482 articles published between 2002 and 2022 were identified. The United States is dominant in intestinal barrier research, whereas the University of Chicago is the most active institution. Jerrold from Harvard Medical School was the most productive authors with the most citations. The journals Inflammatory Bowel Disease and Gastroenterology have made significant contributions in this field. The keywords appearing at high frequency related to the intestinal barrier in IBD were detected, including nuclear factor kappa B, tumor necrosis factor-α, apoptosis, oxidative stress and probiotics. Among them, antioxidants, Akkermansia muciniphila, nanoparticles, short-chain fatty acids and extracellular vesicles have received growing interest in recent research.
    CONCLUSION: The intestinal barrier field is developing rapidly with extensive cooperation. Targeting the gut microbiota and dietary metabolism to regulate the intestinal barrier has shown promising prospective applications and has generated broad interest. The importance of the intestinal barrier in IBD is gradually being fully recognized, providing a new therapeutic perspective for improving inflammation and prognosis.
    Keywords:  Bibliometrics; Hotspots; Inflammatory bowel disease; Intestinal barrier; Visualization
    DOI:  https://doi.org/10.3748/wjg.v29.i36.5254
  29. Cureus. 2023 Sep;15(9): e46179
      Temporomandibular joint (TMJ) is a bicondylar joint. Various conditions have the same clinical presentation as TMJ dysfunction, which requires a thorough assessment of active and passive movements and palpation of the joints surrounding the joint. Many times, TMJ dysfunction occurs due to an alteration in the cervical spine. The patient complains of clicking or popping sound at the jaw and a reduced maximum mouth opening. The conditions that lead to TMJ dysfunction include bruxism, arthritis, stress, injury to the jaw, and overuse. The trend of the available literature has changed from 1972 to 2021 to assess changing trends in the publication on TMJ about authors, country, collaboration of the institutes, and the journal. We have done this bibliometric assessment. The articles were collected from the PubMed database; the keywords used were temporomandibular dysfunction (TMD), neck pain, physiotherapy, and rehabilitation. A total of 437 articles were found from 1975 to 2021, which were then converted into pictorial forms using the CiteSapce R software, and the data were interpreted. The analysis of the bibliometrics of publications on TMD, neck pain, and functional disability between the years 1975 and 2021 shows a total of 437 articles were published. The articles were from 196 sources; the highest number of publications were seen from 2014 until 2021, with the highest number of published papers by author Yoo WG and the highest number of articles published by the Journal of Physical Therapy Science. This bibliometric analysis depicts that the quantity of literature on TMD and the forward head has increased, as has the effectiveness of physical therapy interventions on the forward head in terms of correcting temporomandibular dysfunction.
    Keywords:  bibliometric analyis; forward head; functional disability; neck pain; physical therapy; tmd; tmj
    DOI:  https://doi.org/10.7759/cureus.46179
  30. Hum Vaccin Immunother. 2023 Dec 15. 19(3): 2269788
      To evaluate the temporal and spatial distribution of the knowledge network about tumor microenvironment and prognoses and explore new research hot spots and trends. Articles and reviews on tumor microenvironment and prognoses in the Web of Science journal from January 1999 to April 2022 were included. We used the CiteSpace and VOSviewer software to analyze the knowledge network composed of journals, institutions, countries, authors, and keywords. Frontiers in Immunology, Cancers, and Frontiers in Oncology have published more than 10% of articles in this field. China and the United States have contributed the most articles. Fudan University and Sun Yat-Sen University are the most active institutions. The authors in this field work closely; Zhang Wei and Douglas have made outstanding contributions. The three main research areas of tumor microenvironment and prognoses are microenvironment, prognosis, and immunotherapy. Until 2020, the main keywords were endothelial growth factor and adhesion. In the past three years, survival analysis, immune cell infiltration, and prediction model have been used. It can be seen that the focus in this field has shifted from tumor cell behavior and directly related molecules to prognosis prediction and non-tumor cells in the microenvironment. The future research trend may be to study the changes in the tumor microenvironment to predict the prognosis and guide the treatment. VOSviewer, CiteSpace, and Microsoft Excel 2019 were used to conduct a comprehensive visual analysis of the research on tumor environment and prognoses and provide valuable reference materials for researchers.
    Keywords:  Immune cell; cancer therapy; immune checkpoint; prognoses; tumor microenvironment
    DOI:  https://doi.org/10.1080/21645515.2023.2269788
  31. J Pain Res. 2023 ;16 3591-3611
      Dysmenorrhea, classified as primary dysmenorrhea and secondary dysmenorrhea, is a common gynecological symptom that seriously affects female daily life. At present, studies on dysmenorrhea are numerous and complex. To better reflect the trend and innovative progress of dysmenorrhea-related research, this study screened papers on the Web of Science from January 1, 1992, to December 31, 2022. A total of 1012 papers were selected and analyzed for their affiliated countries, institutions, authors, keywords, etc. China is the country with the most academic output, Beijing University of Traditional Chinese Medicine is the most influential institution, and Yang Jie, from Chengdu University of Traditional Chinese Medicine, China, is the scholar with the most papers. We consider that the current research focus is on pathogenesis, treatment, epidemiology, and self-management. With increasing research on functional connectivity between dysmenorrhea and various brain regions, functional connectivity has gradually become the forefront of research. We hope our study can promote the further study of dysmenorrhea.
    Keywords:  management; pathogenesis; traditional Chinese medicine; treatment
    DOI:  https://doi.org/10.2147/JPR.S430233
  32. Neurosurg Focus. 2023 Nov;55(5): E4
      OBJECTIVE: The "leaky academic pipeline" describes how female representation in leadership positions has remained stagnant despite an increase in the number of female trainees. Female mentorship to female mentees, and female role models at higher academic positions have been shown to positively influence academic productivity. To the authors' knowledge, the impact of female editorial board representation on authorship trends in neurosurgical journals remains undescribed. This study aimed to analyze trends in the representation of female topic editors and its impact on female authorship within Neurosurgical Focus over a 10-year period.METHODS: Publicly available data were collected from the journal's website, inclusive from January 2013 to December 2022. The articles were grouped into technical and nontechnical themes based on their relevance to specific technical details regarding surgical techniques. Female gender-concordant publications were defined as publications having a female first author (or co-first author) and a female senior author. Linear regression analysis determined trends in publishing. Odds ratios and 95% CIs were calculated using logistic regression analysis. Pearson correlation and cross-correlation analyses were used to examine each pairwise comparison of time series. The statistical significance of associations was evaluated using t-tests and chi-square and Fisher's exact tests.
    RESULTS: The number of female topic editors and gender-concordant authors increased over time (p < 0.05). Women accounted for ≥ 50% of the topic editors on nontechnical themes relevant to education and gender diversity. Having a female senior author was associated with higher publication productivity for original research and review articles among female authors (OR 13.73, 95% CI 1.75-394.31; p < 0.05). Female authors had higher odds of publishing editorials with a female topic editor (OR 3.81, 95% CI 1.37-11.02; p < 0.01). Publications with female first and senior authors were significantly more likely to have female topic editors (OR 4.05, 95% CI 1.38-12.92; p < 0.01). A positive association was observed between female senior authors and female topic editors at lag -8, with a correlation coefficient of 0.19 (p = 0.03).
    CONCLUSIONS: Female attending-to-female trainee mentorship and female representation among editorial boards play a crucial role in enhancing academic productivity among women. Efforts to sustain academic productivity during the early-career period would presumably help increase female representation in neurosurgery.
    Keywords:  authorship; diversity; editorial representation; publication productivity; women in neurosurgery
    DOI:  https://doi.org/10.3171/2023.8.FOCUS23461
  33. Heliyon. 2023 Oct;9(10): e21109
      Background: Diabetic retinopathy (DR) is a common complication in diabetic patients. DR is also a neurodegenerative disease. Patients with hyperglycemia, hyperlipidemia, and hypertension are vulnerable to retinopathy development. While the roles of blood glucose and blood pressure in the development of retinopathy have been extensively studied, the relationship between body fat and DR pathogenesis and the impact of lipid-reducing drugs on DR has just emerged as a research hotspot in DR study. We aim to visualize the contributions and cooperation of reporters, organizations, and nations, in addition to the research hotspots and trends in DR-related lipid research from 1993 to 2023, by bibliometric analysis.Methods: We extracted all publications about DR-related lipid research from 1993 to 2023 from the Web of Science Core Collection, and bibliometric features were studied using VOSviewer and the CiteSpace program.
    Results: 1402 documents were retrieved. The number of studies has risen consistently for three decades, from an average of 16.8/year in the 1990s to 28.8/year in the 2000s, 64.5/year in 2010s, and reached 112/year in 2020-2022, confirming they are hot research topic in the field. These reports were from 93 nations/regions, with the USA, China, Japan, Australia, and England taking the leading positions. Diabetes Research and Clinical Practice was the journal that published the most studies, and Diabetes Care was the most quoted. We identified 6979 authors, with Wong TY having the most papers and being the most commonly co-cited. The most popular keyword, according to our research, is diabetic retinopathy. Oxidative stress, diabetic macular edema (DME), lipid peroxidation, and other topics have often been investigated.
    Conclusion: DR-related lipid research is conducted mainly in North America, Asia, Oceania, and Europe. Much study has centered on the relationship between lipid-lowering therapy and DR pathogenesis. These studies strongly support using lipid-reducing medications (fenofibrate, statins, and omega-3 PUFAs), combined with hyperglycemia and hypertension therapy, to prevent and treat DR. However, the impact of fenofibrate or statin on retinopathy is not correlated with their action on blood lipid profiles. Thus, more randomized clinical trials with primary endpoints related to DR in T1D or T2D are merited. In addition, the lipid biomarker for DR (lipid aldehydes, ALEs, and cholesterol crystals), the action of lipid-reducing medicines on retinopathy, the mechanism of lipid-lowering medications preventing or curing DR, and ocular delivery of lipid-lowering drugs to diabetic patients are predicted as the research focus in the future in the DR-related lipid research field.
    Keywords:  Bibliometric; CiteSpace; Diabetic retinopathy; Lipid metabolism; Lipid-lowering drugs; VOSviewer
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e21109
  34. Zhonghua Shao Shang Za Zhi. 2023 Oct 20. 39(10): 977-984
      Objective: To analyze the literature on electric burns published at home and abroad, and to explore the research hotspots and frontiers of electric burns. Methods: The bibliometric method was used. The Chinese and English literature related to electric burns published in China National Knowledge Infrastructure, Wanfang database, VIP database and the core collection of Web of Science database from January 1, 2013 to December 31, 2022 were searched respectively, and the CiteSpace 6.2.R2 software was used for analysis. The number of papers, authors, countries, and institutions of Chinese and English literature were counted respectively, and the co-occurrence analysis of keywords and mutation analysis and cluster analysis on the basis of the co-occurrence analysis were conducted, besides, the clustering time line figure was obtained after the keywords were sorted by time to explore the current research status and the evolution process of hotspots in the field of electric burns. Results: A total of 398 English papers were retrieved from the core collection of Web of Science database, and a total of 523 Chinese papers were retrieved from China National Knowledge Infrastructure, Wanfang database, and VIP database after duplicate check. From 2013 to 2022, the number of English literature published in the field of electric burns showed a steadily upward trend, and the number of published Chinese literature showed a downward trend and tended to be stable. In Chinese literature, a total of 302 authors as the first author published papers related to electric burns, with 17 core authors published ≥3 papers; in English literature, a total of 320 authors as the first author published papers related to electric burns. Researches on electric burns were carried out in 65 countries, with United States having the most cooperation with other countries and the largest number of papers published. A total of 512 institutions at home and abroad published papers related to electric burns, and the institutions with the largest number of Chinese and English papers were Shanghai Electric Power Hospital in China (n=14) and Hallym University in Korea (n=11), respectively. A total of 1 176 Chinese keywords and 1 068 English keywords were included for co-occurrence analysis after excluding keywords related to the searching words. The top three keywords in frequency in Chinese literature were surgical flap, wound repair, and nursing, and the top three keywords in frequency in English literature were management, epidemiology, and children. Ten clusters were obtained by keyword analysis in Chinese literature, and the largest cluster was wound healing, followed by clinical effects and surgical flaps. Seven clusters were obtained by keyword analysis in English literature, and the largest cluster was reconstructive surgical procedures, followed by chronic pain and shock. The persistent clusters in Chinese literature were wound healing and clinical outcomes, etc., and the prominent nodes in the recent two years were surgical timing, limb electric burns, and hypertrophic scars; the persistent clusters in English literature were reconstructive surgical procedures and chronic pain, etc., and the prominent nodes in the recent two years were predictors and burn management, etc. In Chinese literature, the keyword with the longest duration of mutation (2017-2021) was wrist electric burns, and the keyword with the highest intensity of mutation was flap repair; in English literature, the keyword with the longest duration of the mutation (2019-2022) was voltage, and the keyword with the highest intensity of mutation was prevention. Conclusions: There are similarities and differences in the research directions and hotspots of electric burns at home and abroad. Surgical flap repair is a common research hotspot at home and abroad. At present, domestic research focuses on wound healing, wrist electric burns, and other aspects, while international research focuses on treatment management, epidemiology, reconstruction, and other aspects.
    DOI:  https://doi.org/10.3760/cma.j.cn501225-20230511-00167
  35. Ann Med Surg (Lond). 2023 Nov;85(11): 5538-5549
      Background: Bacterial biofilms, which can protect bacteria from host immune response and drug attack, are an important factor in the difficult healing of chronic wound infection, which has become a major problem in medical development. This paper aimed to analyze literature related to bacterial biofilm wound treatment published between 2012 and 2022 using bibliometric and visual analysis.Methods: Publications related to bacterial biofilm wound treatment from 2012 to 2022 were selected from the Web of Science Core Collection. Microsoft Excel 2021, bibliometrics, CiteSpace6.1, and VOSviewer1.6.18 were used to extract and analyze data.
    Results: A total of 940 articles were published between 2012 and 2022, with the United States being the leading country (with 302 papers, 32.13%) and the University of Copenhagen in Denmark being the leading institution (with 26 published articles) in the field. Steven L Percival, a British academic, published the most articles (14). In the field of bacterial biofilm wound treatment, keywords suggested that the research gradually transitioned from lower limb venous ulcer, negative pressure-assisted healing to chronic wound, in-vitro bacterial biological model research, and then to the development of more microscopic and more advanced technologies such as antibacterial activity and nanomaterials. "Nanoparticles", "inhibition/antibacterial", "delivery", "gold nanoparticles", "hydrogel", "wound healing", etc., may become new research hotspots in this field.
    Conclusion: There is a lack of specific and effective treatment methods for diagnosing and treating bacterial biofilms in wounds. Through the development of multidisciplinary cooperation, early diagnosis and treatment of bacterial biofilms in wounds can be achieved. These data may provide a useful reference for scholars studying more effective bacterial biofilm wound treatment.
    Keywords:  microbiology; treatment; web of science; wound bacterial biofilm; wound healing
    DOI:  https://doi.org/10.1097/MS9.0000000000001321
  36. Heliyon. 2023 Oct;9(10): e20985
      Sustainable procurement has emerged as a crucial strategy to address environmental and social challenges while promoting responsible sourcing and procurement practices. This research presents a comprehensive scientometric analysis and visualization of 1044 publications from 1997 to July 2023 through a co-author, co-word, and co-citation analysis on sustainable procurement from the Scopus core collection database using VOSviewer and Gephi software. Prominent research areas include green procurement, sustainable procurement, sustainability, procurement, and supply chain. Leading institutions are the University of Southern Denmark, European Business School (EBS) University, Germany and the University of Louvain, Belgium, with the United Kingdom, United States, and China as citation leaders. The Top sustainable procurement outlets are the Journal of Cleaner Production, the International Journal of Production Economics, the Journal of Business Ethics, Sustainability, and Supply Chain Management. By providing a holistic overview of the sustainable procurement research landscape, this study contributes to evidence-based decision-making and fosters a collaborative approach towards achieving a more sustainable and socially responsible world essential for facilitating sustainability efforts. The findings serve as a foundation for future research and policy development, facilitating knowledge exchange and driving positive change in procurement practices.
    Keywords:  Green procurement; Scientometric analysis; Supply chain management; Sustainability; Sustainable procurement; Sustainable sourcing
    DOI:  https://doi.org/10.1016/j.heliyon.2023.e20985
  37. Int J Transgend Health. 2023 ;24(4): 381-396
      Background: Transgender people face numerous obstacles to accessing adequate, affordable, and appropriate sexual and reproductive health (SRH) services as outlined by the UN's Sustainable Development Goal 3.7 target of achieving universal access to SRH services by 2030. However, transgender SRH sits as a poorly researched area within public health that makes it difficult to understand the current dilemmas facing transgender SRH. This article reports the findings of a study aimed at taking stock of global research in transgender SRH.Methods: A bibliometric analysis, used to gain insights from the retrieved literature's metadata, alongside a content analysis were utilized to examine the growth, impact, and content of retrieved articles.
    Results: Nine hundred fourteen journal articles were retrieved, predominately in English (884; 96.7%). These involved 3653 authors from 46 affiliated countries. Most frequent keywords included HIV, PrEP, and gender identity; corresponding to the SRH issues studied, namely HIV/AIDs and gender reassignment. Top cited and overall articles originated heavily from US affiliated authors. Content analysis outlined the articles' inclusion of the transgender community to largely have a mixed focus with cisgender people in research, these articles largely disease-focused and conducted within cities in the United States.
    Conclusions: Growth in transgender SRH research was minimal until the early-2010s, after which a steep rise can be observed. Research retrieved has a disproportionate clinical and biomedical focus around HIV and related STI issues suggesting a failure to engage with reproductive justice and more comprehensive rights-based understanding of SRH. The sustained use of derogative language suggests a need for greater inclusion and awareness of trans identities within research and publishing. The dominance of the United States in authorship and as a site of research establishes the need for more geographically diverse research, trans, and LMIC-led research enquiry and creating greater opportunities for cross-cultural, comparative, and collaborative scholarly work.
    Keywords:  Bibliometric analysis; content analysis; health; human rights; reproductive justice; sexual and reproductive health; transgender
    DOI:  https://doi.org/10.1080/26895269.2021.1997691
  38. Mar Pollut Bull. 2023 Oct 31. pii: S0025-326X(23)01162-1. [Epub ahead of print]197 115727
      Endocrine Disrupting Chemicals (EDCs) encompass a wide variety of substances capable of interfering with the endocrine system, including but not limited to bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols and phthalates. These compounds are widely produced and used in everyday modern life and have increasingly been detected in aquatic matrices worldwide. In this context, this study aimed to carry out a literature review to assess the evolution of EDCs detected in different matrices in the last thirty years. A bibliometric analysis was conducted at the Scopus, Web of Science, and Google Scholar databases. Data were evaluated using the Vosviewer 1.6.17 software. A total of 3951 articles in English were retrieved following filtering. The results demonstrate a gradual and significant growth in the number of published documents, strongly associated with the increasing knowledge on the real environmental impacts of these compounds. Studied were mostly conducted by developed countries in the first two decades, 1993 to 2012, but in the last decade (2013 to 2022), an exponential leap in the number of publications by countries such as China and an advance in research by developing countries, such as Brazil, was verified.
    Keywords:  Aquatic environments; Developing countries; EDCs; Environmental contamination; Scientometric review
    DOI:  https://doi.org/10.1016/j.marpolbul.2023.115727
  39. Biomed Res Int. 2023 ;2023 5539470
      Digital tools and apps are revolutionizing healthcare and provide creative answers to urgent problems. Through teamwork and the incorporation of digital technologies, dentistry has experienced a remarkable revolution. A large body of scholarly research backs up this trend. The context, trends, and content of digital health technology in oral and dental health are examined in our bibliometric analysis. Using targeted keywords and synonyms, an organized searching technique was used in the Scopus database, yielding 1942 articles that were extracted into a CSV file. To acquire insights into the content, trends, and context, visualization using VOSviewer 1.6.18 and a variety of analyses-including coauthorship, citation, cooccurrence of author keywords, bibliographic coupling, and cocitation-were executed. The analysis revealed that the USA and the UK contributed to a significant quantity of the literature, with newer contributions coming from nations like India. Cone Beam Computed Tomography, Dental Caries, and Artificial Intelligence were prominent keywords. It is important to note that BMC Oral Health was associated with a sizable number of the papers. This bibliometric analysis provides insightful information about the context, content, and trends of digital health in the field of oral and dental health. By implementing the right technology, policymakers can use this information to increase oral health, encourage dental literacy, and improve access to dental treatment. It is vital to take into account the wide variety of technologies and their classifications based on dental services and contextual variables.
    DOI:  https://doi.org/10.1155/2023/5539470
  40. An Acad Bras Cienc. 2023 Oct 30. pii: S0001-37652023000400101. [Epub ahead of print]95(3): e2023953
      
    DOI:  https://doi.org/10.1590/0001-376520232023953
  41. Sci Rep. 2023 Nov 01. 13(1): 18794
      Can we help predict the future impact of researchers using early-career factors? We analyze early-career factors of the world's 100 most prominent researchers across 8 scientific fields and identify four key drivers in researchers' initial career: working at a top 25 ranked university, publishing a paper in a top 5 ranked journal, publishing most papers in top quartile (high-impact) journals and co-authoring with other prominent researchers in their field. We find that over 95% of prominent researchers across multiple fields had at least one of these four features in the first 5 years of their career. We find that the most prominent scientists who had an early career advantage in terms of citations and h-index are more likely to have had all four features, and that this advantage persists throughout their career after 10, 15 and 20 years. Our findings show that these few early-career factors help predict researchers' impact later in their careers. Our research thus points to the need to enhance fairness and career mobility among scientists who have not had a jump start early on.
    DOI:  https://doi.org/10.1038/s41598-023-46050-x
  42. PeerJ. 2023 ;11 e16210
      A bibliometric analysis of current research, hotspots, and development trends was used to develop an overall framework of mechanisms of alpine grassland degradation on the Qinghai-Tibet Plateau. This investigation includes data from 1,330 articles on alpine grassland degradation on the Qinghai-Tibet Plateau, acquired from the Chinese Science Citation Database (CSCD) and Web of Science Core Collection (WOS). Research was divided into three themes: spatial scope and management of typical grassland degradation problems, dynamic mechanisms of grassland degradation and effects of ecological engineering, and grassland degradation risk based on remote sensing technology. The results of the analysis showed that the research can be summarized into three aspects: typical grassland degradation identification, dynamic mechanism analysis of grassland degradation, and grassland ecosystem stability strategy. The main findings can summarized, as follows: (1) Ecological analyses using the river source as a typical region defined the formation of "black soil beach" type degraded grasslands in the region, and promoted the ecological environment management and protection of the alpine grassland by discussing the causes of regional ecological environment changes; (2) Dynamic mechanism analyses of climate change and characteristics analyses of grassland vegetation-soil degradation revealed that alpine grassland degradation is the result of multiple main factors; and (3) Risk prediction methods for grassland degradation, methods of grassland management and sustainable countermeasures for agriculture and animal husbandry development, and the development of a comprehensive index of influencing factors on grassland degradation all indicate that selecting the right grassland restoration measures is the key to grassland restoration. Remote sensing monitoring and high-throughput sequencing technology should be used in future research on grassland ecosystems. In addition, multiscale, multidimensional, and multidisciplinary systematic research methods and long-term series data mining could help identify the characteristics and causes of alpine grassland system degradation. These findings can help identify a more effective coordination of landscape, water, lake, field, forest, grass, and sand management for the prevention of alpine grassland degradation.
    Keywords:  Alpine grassland degradation; Bibliometric method; Black soil beach; Climate change; Grassland degradation risk; Qinghai-Tibet Plateau; Research hot spots
    DOI:  https://doi.org/10.7717/peerj.16210
  43. Aging Clin Exp Res. 2023 Nov 01.
      BACKGROUND: With the increase in the aging population, informal caregivers have become an essential pillar for the long-term care of older individuals. However, providing care can have a negative impact and increase the burden on caregivers, which is a cause for concern.OBJECTIVE: This study aimed to comprehensively depict the concept of "informal caregiver burden" through bibliometric and content analyses.
    METHODS: We searched the Web of Science (WoS) database to obtain bibliometric data and included only papers published between 2013 and 2022. We used content analysis to extract and identify the core concepts within the text systematically.
    RESULTS: Altogether, 934 papers were included in the bibliometric analysis, from which we selected 19 highly impactful papers for content analysis. The results indicate that researchers have focused on exploring the factors that impact informal caregiver burden. Meanwhile, there has been a widespread discussion regarding the caregiver burden among those caring for recipients with specific illnesses, such as dementia, Alzheimer's disease, and cancer, as these illnesses can contribute to varying levels of burden on informal caregivers. In addition, questionnaires and interviews emerged as the predominant methods for data collection in the realm of informal caregiver research. Furthermore, we identified 26 distinct assessment tools specifically tailored for evaluating burden, such as caregiver strain index (CSI).
    CONCLUSION: For future studies, we suggest considering the intersectionality of factors contributing to the burden on informal caregivers. This approach could enhance the well-being of both caregivers and older care recipients.
    Keywords:  Aging population; Bibliometric analysis; Content analysis; Health care; Informal caregiver burden; Long-term care; Patients
    DOI:  https://doi.org/10.1007/s40520-023-02582-w
  44. J Cancer Res Clin Oncol. 2023 Nov 02.
      BANKGROUND: The tumor microenvironment (TME) is an internal environment composed of various cells and an extracellular matrix. Cancer stem cell-derived exosomes (CSC-Exos), as essential messengers involved in various tumor processes, are important carriers for bidirectional communication between the tumor microenvironment and tumor cells and play an important role in the tumor microenvironment. Nevertheless, few bibliometric analyses have been systematically studied in this field.METHODS: Therefore, we aimed to visualize the research hotspots and trends in this field through bibliometrics to comprehend the future evolution of fundamental and clinical research, as well as to offer insightful information and fresh viewpoints. The Scopus database was used to search the research literature related to exosomes and tumor microenvironments after the establishment of this repository. CiteSpace (version 5.8.R3) and VOSviewer (version 1.6.16) were used for visualization and analysis.
    RESULTS: In this study, a total of 2077 articles and reviews were included, with the number of articles on exosomes and tumor microenvironments significantly increasing yearly. Recent trends showed that the potential value of exosomes as "tumor diagnostics" and "the application prospect of exosomes as therapeutic agents and drug delivery carriers" will receive more attention in the future.
    CONCLUSIONS: We revealed the current status and hotspots of tumor stem cell-derived exosomes and tumor microenvironments globally through bibliometrics. The prospect of the regulatory role of CSC-Exos in TME, the potential value of diagnosis, and the application of drug delivery vectors will all remain cutting-edge research areas in the field of tumor therapy. Meanwhile, this study provided a functional literature analysis for related researchers.
    Keywords:  Bibliometric analyses; Cell-derived exosomes; CiteSpace; Tumor microenvironment; VOSviewer; Visualization
    DOI:  https://doi.org/10.1007/s00432-023-05450-2
  45. PLoS One. 2023 ;18(11): e0293663
      We plan to empirically study the assessment of scientific papers within the framework of the anchoring-and-adjustment heuristic. This study is a follow-up study which is intended to answer open questions from the previous study with the same topic Bornmann (2021) and Bornmann (2023). The previous and follow-up studies address a central question in research evaluation: does bibliometrics create the social order in science it is designed to measure or does bibliometrics reflect the given social order (which is dependent on the intrinsic quality of research)? If bibliometrics creates the social order, it can be interpreted as an anchoring-and-adjustment heuristic. In the planned study, we shall undertake a survey of corresponding authors with an available email address in the Web of Science database. The authors are asked to assess the quality of articles that they cited in previous papers. The authors are randomly assigned to different experimental settings in which they receive (or not) citation information or a numerical access code to enter the survey. The control group will not receive any further numerical information. In the statistical analyses, we estimate how (strongly) the quality assessments of the cited papers are adjusted by the respondents to the anchor value (citation counts or access code). Thus, we are interested in whether possible adjustments in the assessments can not only be produced by quality-related information (citation counts), but also by numbers that are not related to quality, i.e. the access code. Strong effects of the anchors would mean that bibliometrics (or any other number) create the social order they are supposed to measure.
    DOI:  https://doi.org/10.1371/journal.pone.0293663
  46. Turk Kardiyol Dern Ars. 2023 Oct 31.
      OBJECTIVE: This study aimed to describe the effects of new academic criteria established in 2016 on the abstracts of the National Congress of the Turkish Society of Cardiology.METHODS: The abstracts presented at 13 consecutive annual congresses were obtained. A literature search was conducted with PubMed, Google Scholar, and Web of Science databases to analyze whether the abstract was published in a scientific journal. The study was divided into 2 time groups according to the new academic criteria published in 2016. Group 1 included 4828 abstracts accepted at National Congress of the Turkish Society of Cardiology between 2009 and 2016, while Group 2 included 2284 abstracts accepted at National Congress of the Turkish Society of Cardiology between 2017 and 2021.
    RESULTS: A total of 7112 abstracts were accepted for the 2009-2021 National Congress of the Turkish Society of Cardiology meetings scientific program. The publication rate (43.2% vs. 23.9%, P < 0.001), number of authors [7(5-9) vs. 4(3-6), P < 0.001], and rate of original investigation (72.3 vs. 56.5%, P < 0.001) were significantly lower in group 2 than in group 1. Among the quality parameters of the journals in which the abstracts were published, the impact factor (0.59 ± 1.71 vs. 0.26 ± 1.09, P < 0.001), the rate of journals in science citation index or science citation index-expanded indexes (70.4 vs. 57.9%, P < 0.001), and the rate of the second or third-quartile class (24.2 vs. 16.1%, P < 0.001) were significantly lower in group 2 as compared to group 1. Being in group 1 oral presentation, original investigation, and cardiac imaging were identified as independent predictors for publication in scientific journals.
    CONCLUSION: This study showed that the 2016 new academic criteria negatively affected the publication processes of accepted abstracts in National Congress of the Turkish Society of Cardiology.
    DOI:  https://doi.org/10.5543/tkda.2023.69226
  47. Environ Sci Pollut Res Int. 2023 Oct 31.
      Environmental plastic wastes are continuously degraded into microplastics (MPs) and nanoplastics (NPs); the latter are more potentially harmful to organisms and human health as their smaller size and higher surface-to-volume ratio. Previous reviews on NPs mainly concentrate on specific aspects, such as sources, environmental behavior, and toxicological effects, but few focused on NPs-related scientific publications from a global point of view. Therefore, this bibliometric study aims to summarize the research themes and trends on NPs and also propose potential directions for future inquiry. Related papers were downloaded from the Web of Science Core Collection database on NPs published from 2008 to 2021, and then retrieved information was analyzed using CiteSpace 6.1 R2 and VOSviewer (version 1.6.). Research on NPs mainly involved environmental behaviors, toxicological effects, identification and extraction of NPs, whereas aquatic environments, especially marine systems, attracted more attentions from these scientists compare to terrestrial environments. Furthermore, the adsorption behavior of pollutants by NPs and the toxicological effects of organisms exposed to NPs are the present hotspots, while the regulation of humic acid (HA) on NPs behaviors and the environmental behavior of NPs in freshwater, like rivers and lakes, are the frontier areas of research. This study also explored the possible opportunities and challenges that may be faced in NPs research, which provide a valuable summary and outlook for ongoing NPs-related research, which may be of intrigue and noteworthiness for relevant researchers.
    Keywords:  Adsorption behavior; Freshwater environment; HA regulation; Nanoplastics; Scientometric analysis; Toxicological effects
    DOI:  https://doi.org/10.1007/s11356-023-30597-3
  48. J Med Life. 2023 Jul;16(7): 967-973
      In response to the COVID-19 pandemic, numerous initiatives have been implemented to ensure open access availability of COVID-19-related articles to make published articles accessible for anyone. This study aimed to assess the impact of the COVID-19 pandemic on open-access publishing in radiology and nuclear medicine. We conducted a comprehensive analysis of articles and reviews published in these fields during the COVID-19 publishing era using the Web of Science database. We analyzed several indicators between COVID-19 and non-COVID-19 related articles, including the number and percentage of open-access articles, the top ten cited articles, and the number of reviews. In total, 67,100 articles were published in radiology and nuclear medicine between January 2020 and June 2022. Among those, more than half (51.1%) were open-access articles. Among these publications, 2,336 were COVID-19-related, and 64,764 were non-COVID-19-related. However, articles related to COVID-19 had an open access rate of 91.5%, compared to only 49.6% of the non-COVID-19-related articles. Moreover, COVID-19-related articles had a higher percentage of highly cited and hot papers compared to articles not related to COVID-19. Moreover, most highly cited studies were related to chest computerized tomography (CT) scan findings in COVID-19 patients. The findings emphasize the significant proportion of open access COVID-19-related publications in radiology and nuclear medicine, facilitating widespread and timely access to everyone.
    Keywords:  COVID-19; nuclear medicine; open access publishing; policymakers; publishing; radiology
    DOI:  https://doi.org/10.25122/jml-2023-0075
  49. J Gastrointest Surg. 2023 Oct 31.
      INTRODUCTION: The proportion of women surgeons is increasing, although women in surgical leadership and research has not kept pace. The Society for Surgery of the Alimentary Tract (SSAT) pledged its commitment to diversity and inclusion in 2016. Our study sought to evaluate the temporal trend of gender representation in leadership, speakership, and research at SSAT.METHODS: Publicly available SSAT meeting programs from 2010 to 2022 were reviewed to assess gender proportions within leadership positions (officers and committee chairs); invited speakerships, multidisciplinary symposia, and committee panel session moderators and speakers; and contributions to scientific sessions (moderator, first author and senior author). Verified individual professional profiles were analyzed to categorize gender as woman, man, or unavailable. Descriptive and trend analyses using linear regression and chi-squared testing were performed.
    RESULTS: A total of 5506 individuals were reviewed; 1178 (21.4%) were identified as women and 4328 (78.6%) as men or did not have available data. The absolute proportion of total female participation increased by 1.05% per year (R2=0.82). There was a statistically significant difference in the total proportion of women participation before and after 2016 (18.5% vs. 27.1%, p<0.01). Increases in the proportion of women were demonstrated in leadership, invited speakerships, multidisciplinary symposia, committee panel sessions, research session moderators, and abstract first authors. The proportion of women senior authors remained stagnant.
    CONCLUSION: Though this upward trajectory in SSAT women participation is encouraging, current trends predict that gender parity will not be reached until 2044.
    Keywords:  Female representation; Gender diversity; Gender parity; Glass ceilings
    DOI:  https://doi.org/10.1007/s11605-023-05865-9
  50. JB JS Open Access. 2023 Oct-Dec;8(4):pii: e23.00067. [Epub ahead of print]8(4):
      Background: Orthopaedic surgery suffers from gender disparity, and annual conferences are visible opportunities to quantify gender representation within a field. Therefore, the purpose of this manuscript was to investigate the prevalence of female speakers and moderators, and male-only panel sessions, at 10 major Orthopaedic Surgery meetings.Methods: Conference programs and details of faculty moderating or presenting in 10 Orthopaedic Surgery annual meetings in 2021 were retrieved. Conferences were selected with the aim of size and diversity in subspecialty topics and included American Association of Hip and Knee Surgeons, American Association for Hand Surgery, American Academy of Orthopaedic Surgeons, American Orthopaedic Society for Sports Medicine, Canadian Orthopaedic Association (COA), European Federation of National Associations of Orthopaedics and Traumatology, North American Spine Society, Orthopaedic Research Society (ORS), Orthopaedic Trauma Association, and Pediatric Orthopaedic Society of North America (POSNA). Primary outcomes included percentage of female chairs and speakers and percentage of male-only panels, while secondary outcomes included number of publications, number of citations, and H-indexes of faculty. Further subgroup comparisons were performed between male-only panels and non-male-only panels and female members and male members.
    Results: Of 207 included sessions, 121 (58.5%) were male-only panels and 150 (12.6%) of 1,188 faculty members were women. Conferences organized by the COA, ORS, and POSNA had higher percentages of female representation, while spine surgery and adult hip/knee reconstruction sessions had more than 70% male-only panels and fewer than 10% female members. There were no significant differences between male members and female members regarding years of practice; however, male members were more likely to hold the title of professor (p < 0.001). Male members and female members stratified by quartiles of publications, citations, and H-indexes, moderated or participated in similar numbers of sessions, indicating an absence of selection bias.
    Conclusions: There is a high prevalence of male-only panels (58.5%) and an overall lack of female representation (12.6%) in 10 major Orthopaedic Surgery meetings. Male members and female members from these conferences were found to have similar qualifications academically. Specific strategies such as the elimination of male-only panels, selecting diverse conference organizers, and forming conference equity, diversity, and inclusion committees can help achieve cultural change.
    Level of Evidence: Level V.
    DOI:  https://doi.org/10.2106/JBJS.OA.23.00067
  51. PLoS One. 2023 ;18(11): e0293669
      PURPOSE: The feasibility of measuring the touristic ecosystem in European countries with a Mediterranean coast based on various parameters, including diversity, turnover, and the number of tourists, was investigated in this study. The data from the period between 2004 and 2020 were analyzed.METHODOLOGY: A distribution analysis of annual tourist gains was conducted, and the distribution of incoming tourists across the countries was examined based on their area, using Atkinson, Theil, and Hoover inequality indices. Secondary data from the World Bank were utilized by the authors for the 13 countries studied. It was suggested by the authors that the Mediterranean region could be analyzed based on factors such as the length of the coast, the number and type of hotel beds, and the volume of coastal tourism. This study can be expressed as a mixed methodology supported by bibliometric analysis.
    FINDINGS: An overall improvement in the distribution of tourists was indicated by the results of the analysis, with the exception of a decline in 2016 and 2020, as confirmed by all three indices. The most significant decline in 2020 was shown by the Hoover Index.
    ORIGINALITY: This study is a significant contribution to the existing literature, as it is the first to analyze the distribution of tourists considering the Mediterranean Basin coast length and the number of tourists of the illustrated countries, using the Atkinson, Theil, and Hoover inequality indices. The study was deemed original and supported by bibliometric analysis. The results of this study have important managerial implications.
    DOI:  https://doi.org/10.1371/journal.pone.0293669
  52. Plast Surg (Oakv). 2023 Nov;31(4): 401-407
      Background: Valuable research requires contribution from many experts; however, the "et al." truncation often keeps all individuals from being acknowledged. The adoption of a new citation rule (list all authors up to 30, followed by et al.) would allow more authors to be acknowledged. The purpose of this study was to (1) explore the citation styles of the top 10 Plastic Surgery, Surgery, and Medical journals and (2) compare the number of extra pages required, and the number of additional authors acknowledged when the "new rule" is implemented. Methods: The top 10 journals in Plastic Surgery, Surgery, and Medicine were identified. The citation styles used in each of the journals were reviewed and the reference list from a recently published article was extracted. The original reference list was used to create an Extended Reference List using the new rule. Results: Most journals implemented "et al." when seven or more authors were listed. Ten articles required additional pages to accommodate the Extended Reference List. When the "et al." truncation was introduced after 30 authors, there was an almost 100% chance of all authors being included. The adoption of this rule rarely resulted in the need for additional pages, especially within Plastic Surgery. Conclusions: In a time of electronic publishing, where constraints such as article and journal page length should not be important factors, all authors should be recognized. The use of the "et al." truncation should be discouraged by all individuals involved in the production and publication of research. Scenario You are asked by the Editor-in-Chief of your specialty's journal to review an article in your area of expertise. You gladly accept the task. One of the questions you are required to answer in your review is whether the authors of the submitted manuscript have missed any important articles in their references. As you are the recognized expert in this field, you glance at the references to see if a key article you published 3 years earlier has been included. The first author of that article was a junior resident in your service and the research was done under your supervision. To their credit, the authors included the said article, but you are dismayed that the reference does not include your name. It includes only the names of the first three authors, all junior residents in your service. Your name, and the names of many others, are lost in the et al. truncation.
    DOI:  https://doi.org/10.1177/22925503211051109
  53. Ambio. 2023 Oct 31.
      Ecological civilization has emerged as an innovative form of civilization in China, and sustainable development has been widely recognized as a globally leading development model. These two concepts are closely related. The international English literature focuses on hot topics in the field of sustainable development such as climate change, urbanization, government management, and ecosystems, while the Chinese literature emphasizes ecological civilization concepts with Chinese characteristics, such as green development, beautiful China, and scientific development concepts. Ecological civilization and sustainable development are both responses to resource, environmental, and ecological crises and have emerged from the same historical background. The two concepts complement each other, with ecological civilization providing an ideological foundation for sustainable development, and sustainable development serving as the implementation path and concrete manifestation of ecological civilization. To deepen research on ecological civilization and sustainable development, it is necessary to build a global community with a shared future, address the major strategic needs of different countries or regions, innovate and develop interdisciplinary theories, methods, and technologies, strengthen international cooperation, provide disciplinary support for ecological civilization and sustainable development research, and provide country-specific research solutions for global and regional sustainable development.
    Keywords:  Bibliometrics; China; Ecological civilization; Global; Sustainable development
    DOI:  https://doi.org/10.1007/s13280-023-01947-9
  54. Front Immunol. 2023 ;14 1272809
      Background: The immune system, composed of organs, tissues, cells, and proteins, is the key to protecting the body from external biological attacks and inflammation. The latter occurs in several pathologies, such as cancers, type 1 diabetes, and human immunodeficiency virus infection. Immunophenotyping by flow cytometry is the method of choice for diagnosing these pathologies. Under inflammatory conditions, the peripheral blood mononuclear cells (PBMCs) are partially activated and generate intracellular pathways involving Ca2+-dependent signaling cascades leading to transcription factor expression. Ca2+ signaling is typically studied by microscopy in cell lines but can present some limitations to explore human PBMCs, where flow cytometry can be a good alternative.Objective: In this review, we dived into the research field of inflammation and Ca2+ signaling in PBMCs. We aimed to investigate the structure and evolution of this field in a physio-pathological context, and then we focused our review on flow cytometry analysis of Ca2+ fluxes in PBMCs.
    Methods: From 1984 to 2022, 3865 articles on inflammation and Ca2+ signaling in PBMCs were published, according to The Clarivate Web of Science (WOS) database used in this review. A bibliometric study was designed for this collection and consisted of a co-citation and bibliographic coupling analysis.
    Results: The co-citation analysis was performed on 133 articles: 4 clusters highlighted the global context of Ca2+ homeostasis, including chemical probe development, identification of the leading players in Ca2+ signaling, and the link with chemokine production in immune cell function. Next, the bibliographic coupling analysis combined 998 articles in 8 clusters. This analysis outlined the mechanisms of PBMC activation, from signal integration to cellular response. Further explorations of the bibliographic coupling network, focusing on flow cytometry, revealed 21 articles measuring cytosolic Ca2+ in PBMCs, with only 5 since 2016. This final query showed that Ca2+ signaling analysis in human PBMCs using flow cytometry is still underdeveloped and investigates mainly the cytosolic Ca2+ compartment.
    Conclusion: Our review uncovers remaining knowledge gaps of intracellular players involved in Ca2+ signaling in PBMCs, such as reticulum and mitochondria, and presents flow cytometry as a solid option to supplement gold-standard microscopy studies.
    Keywords:  B cells; Ca2+ signaling; T cells; flow cytometry; immune cells; inflammation; kinetics
    DOI:  https://doi.org/10.3389/fimmu.2023.1272809
  55. Braz J Med Biol Res. 2023 ;pii: S0100-879X2023000100680. [Epub ahead of print]56 e13052
      Darwin's theory of evolution, which is based on variation, heredity, and selection, includes all biological fields and spreads to other areas such as philosophy. Medicine is an example of how the evolutionary perspective can greatly improve the understanding of concepts in an area, as human health and pathological conditions are under the effect of evolution. Evolutionary medicine is an emerging paradigm for understanding human heterogeneity, health, and diseases. Nevertheless, there are indications that medical research and practice are only marginally affected by these ideas. Here, we investigate how concepts of biological evolution are employed in medical research. We use a bibliometric approach to look for the presence and frequency of biological evolution-related concepts in medical articles. The distribution of these concepts over the years is analyzed according to the medical specialty and the impact of the journal. Our data showed that: i) only a small percentage of articles in medical journals have an evolutionary perspective; ii) medical journals where these evolution-based articles are published focus on basic science, theoretical medicine, and less frequently, on applied medicine; iii) these articles are mostly from the microbiology, immunology, neurology, psychology, behavior, and oncology fields; and iv) viruses are the most frequently covered microorganisms, followed by bacteria, fungi, and protozoans. The collection of our results, considering the importance of evolutionary medicine in the medical field, highlights the need for a decisive change in perspective in medical research.
    DOI:  https://doi.org/10.1590/1414-431X2023e13052
  56. J Pharm Health Care Sci. 2023 Nov 01. 9(1): 34
      BACKGROUND: We previously demonstrated that in a Japanese national university's medical faculty, overall paper publication frequency increased between 1979-1980 and 2017-2018, while original paper publication did not increase. Further, publication language changed from predominantly Japanese to English. However, whether these trends are specific to medicine or representative of other faculties remains unclear.METHODS: We diachronically analyzed annual university library-produced publication reports for four pharmaceutical and three medical units between 1979-1980 and 2019-2020, elucidating how publication frequency, type, and language medium changed.
    RESULTS: All publication types increased for the pharmaceutical faculty, from 2.87 per faculty member per year to 10.77. Publication of original papers more than doubled, from 1.06 per faculty member per year to 2.37. This increase was exclusively in English publication, with no publication of Japanese original papers in 2019-2020. This contrasts with medicine, which, while it demonstrated similar increases in all publication types combined, from 4.92 papers per faculty member per year to 12.78, did not demonstrate as striking an increase in total original paper publication (English and Japanese), from 1.21 papers per faculty member per year to 1.30. However, these two faculties observed similar trends in that English largely replaced Japanese original paper publication. That both faculties' Japanese original paper publication decreased suggests English language original paper publication comes at the expense of publishing in Japanese. Concerning both faculties together, the increase in publishing frequency for all publication types more than tripled from 4.01 to 12.38. This was largely driven by changes in conference paper publication for the pharmaceutical sciences faculty, where English publication increased 2,775% (0.06 to 1.7 papers per faculty member per year) and Japanese language publication 258% (1.33 to 4.77). While conference paper publication did increase for the medical sciences, its change in total publication frequency was largely driven by 'other' types of publication, which increased from 0.51 publications per faculty member per year in 1979-1980 to 5.41 in 2019-2020, largely driven by Japanese language publication.
    CONCLUSION: In 2019-2020, pharmaceutical sciences faculty members largely published original papers in English, so postgraduate education should consider the future likelihood of graduates needing to publish in English.
    Keywords:  Diachronic analysis; Document analysis; Language of publication; Pharmaceutical faculty publication; Type of publication
    DOI:  https://doi.org/10.1186/s40780-023-00302-0
  57. Health Info Libr J. 2023 Oct 30.
      BACKGROUND: The COVID-19 pandemic has triggered a significant increase in academic research in the realm of social sciences. As such, there is an increasing need for the scientific community to adopt effective and efficient methods to examine the potential role and contribution of social sciences in the fight against COVID-19.OBJECTIVES: This study aims to identify the key topics and explore publishing trends in social science research pertaining to COVID-19 via automated literature analysis.
    METHODS: The automated literature analysis employed utilizes keyword analysis and topic modelling technique, specifically Latent Dirichlet Allocation, to highlight the most relevant research terms, overarching research themes and research trends within the realm of social science research on COVID-19.
    RESULTS: The focus of research and topics were derived from 9733 full-text academic papers. The bulk of social science research on COVID-19 centres on the following themes: 'Clinical Treatment', 'Epidemic Crisis', 'Mental Influence', 'Impact on Students', 'Lockdown Influence' and 'Impact on Children'.
    CONCLUSION: This study adds to our understanding of key topics in social science research on COVID-19. The automated literature analysis presented is particularly useful for librarians and information specialists keen to explore the role and contributions of social science topics in the context of pandemics.
    Keywords:  Artificial Intelligence (AI); bibliometrics; pandemic; review, literature; social sciences
    DOI:  https://doi.org/10.1111/hir.12508
  58. Front Psychol. 2023 ;14 1244404
      Introduction: This paper aims to identify and compare changes in trends and research interests in soccer articles from before and during the COVID-19 pandemic.Methods: We compared research interests and trends in soccer-related journal articles published before COVID-19 (2018-2020) and during the COVID-19 pandemic (2021-2022) using Bidirectional Encoder Representations from Transformers (BERT) topic modeling.
    Results: In both periods, we categorized the social sciences into psychology, sociology, business, and technology, with some interdisciplinary research topics identified, and we identified changes during the COVID-19 pandemic period, including a new approach to home advantage. Furthermore, Sports science and sports medicine had a vast array of subject areas and topics, but some similar themes emerged in both periods and found changes before and during COVID-19. These changes can be broadly categorized into (a) Social Sciences and Technology; (b) Performance training approaches; (c) injury part of body. With training topics being more prominent than match performance during the pandemic; and changes within injuries, with the lower limbs becoming more prominent than the head during the pandemic.
    Conclusion: Now that the pandemic has ended, soccer environments and routines have returned to pre-pandemic levels, but the environment that have changed during the pandemic provide an opportunity for researchers and practitioners in the field of soccer to detect post-pandemic changes and identify trends and future directions for research.
    Keywords:  BERT; COVID-19; data science; football; pandemic; research trend; soccer; topic modeling
    DOI:  https://doi.org/10.3389/fpsyg.2023.1244404
  59. Front Mol Biosci. 2023 ;10 1221337
      Introduction: Arterial hypertension (AH) is a pervasive global health concern with multifaceted origins encompassing both genetic and environmental components. Previous research has firmly established the association between AH and diverse genetic factors. Consequently, scientists have conducted extensive genetic investigations in recent years to unravel the intricate pathophysiology of AH. Methods: In this study, we conducted a comprehensive bibliometric analysis employing VOSviewer software to identify the most noteworthy genetic factors that have been the focal point of numerous investigations within the AH field in recent years. Our analysis revealed genes and microRNAs intricately linked to AH, underscoring their pivotal roles in this condition. Additionally, we performed molecular docking analyses to ascertain microRNAs with the highest binding affinity to these identified genes. Furthermore, we constructed a network to elucidate the in-silico-based functional interactions between the identified microRNAs and genes, shedding light on their potential roles in AH pathogenesis. Results: Notably, this pioneering in silico examination of genetic factors associated with AH promises novel insights into our understanding of this complex condition. Our findings prominently highlight miR-7110-5p, miR-7110-3p, miR-663, miR-328-3p, and miR-140-5p as microRNAs exhibiting a remarkable affinity for target genes. These microRNAs hold promise as valuable diagnostic and therapeutic factors, offering new avenues for the diagnosis and treatment of AH in the foreseeable future. Conclusion: In summary, this research underscores the critical importance of genetic factors in AH and, through in silico analyses, identifies specific microRNAs with significant potential for further investigation and clinical applications in AH management.
    Keywords:  arterial hypertension; epigenetic factors; genetic factors; in silico analyses; miRNA
    DOI:  https://doi.org/10.3389/fmolb.2023.1221337
  60. Front Res Metr Anal. 2023 ;8 1239726
      Introduction: This study examines the associations between time series, termed "coherency," using spectral analysis. Coherence squared, analogous to the squared correlation coefficient, serves as a metric to quantify the degree of interdependence and co-evolution of individual nodes.Methods: We utilized spectral analysis to compute coherence squared, unveiling relationships and co-evolution patterns among individual nodes. The resultant matrix of these relationships was subjected to network analysis.
    Results: By conducting a case study analyzing tweets associated with the co-hashtags #StopAsianHate and #BlackLivesMatter, we present a novel approach utilizing coherency network analysis to investigate the dynamics of social media text. Frequency domain analysis aided in calculating coherence squared, effectively illustrating the relationships and co-evolution of individual nodes. Furthermore, an analysis of the phase spectrum's slope facilitated the determination of time lag and potential causality direction between highly co-evolved node pairs.
    Discussion: Our findings underline the potential of coherency network analysis in comprehending the intricate dynamics of social media text. This approach offers valuable insights into how topics, sentiments, or movements manifest and evolve within the digital realm. Future research should explore diverse datasets and domains to broaden our understanding of this novel analytical technique.
    Keywords:  coherency network analysis; hashtag activism; semantic network analysis; social media text analysis; tweet analysis
    DOI:  https://doi.org/10.3389/frma.2023.1239726
  61. Front Vet Sci. 2023 ;10 1268821
      Animal welfare is a field with increasing significance and has been raising huge concerns of the public and the political stage. Cats and dogs possess an important role in human life, but their welfare is not always secured from a legal aspect. This review aimed to describe the evolution and geographical distribution of "cats and dogs" and "puppies and kittens" welfare literature over the last 40 years, distinguish the main research topics studied and highlight gaps in knowledge. A search using Scopus® was performed with different search strings and predetermined filters as time range, language, and subject area. A total of 2,725 scientific literature records were retrieved but only the ones that referred to cats and dogs' welfare aspects were retained. The final 1,775 records were processed through descriptive statistics, and text mining and topic analysis procedures were performed on their titles and abstracts. The results showed that the number of studies has been increasing, especially in Europe and North America. "Shelter" was the most frequent word, followed by "behavior," "owner" and "adopt." The nine topics that emerged from the analysis were breeding, stress and housing conditions, welfare and pain assessment, public health, shelter management and euthanasia, behavioral problems, health issues and management, human-animal interaction, and owners' and veterinarians' perceptions. While stress and housing conditions, public health, and owners' and veterinarians' perceptions were the most studied topics, human-animal interaction was the least studied. This review confirmed the increasing research and interest in cats' and dogs' welfare and showed gaps in knowledge where further studies are needed.
    Keywords:  behavior; canine; companion animals; feline; machine learning; systematic review; well-being
    DOI:  https://doi.org/10.3389/fvets.2023.1268821
  62. Neurosurg Focus. 2023 Nov;55(5): E16
      OBJECTIVE: Recent trends have shown more women entering neurosurgery, but large gender gaps in the number of female trainees continue to persist. A previous study on the gender diversity of residents and faculty in neurosurgery training programs found that only 18.2% of residents and 8.7% of faculty at neurosurgical training programs were female. The goal of this study was to better understand program characteristics that may affect the recruitment of female residents and the gender composition of neurosurgery residency programs.METHODS: The authors assessed publicly available information on websites and social media from 116 Accreditation Council for Graduate Medical Education (ACGME)-accredited neurosurgery residency programs from the 2022-2023 academic year. Data collected on residents included gender and postgraduate year (PGY), geographic region, accreditation year, and complement size for programs. The authors analyzed the distribution of female residents at each program and compared accreditation year, program size, program geographics, PGY, and acceptance rates.
    RESULTS: There were 1602 residents across the 116 programs included in this study: 1223 (76.3%) male and 379 (23.7%) female residents. The gender distribution of female residents showed 29 programs had 30% or more female residents, 50 programs had between 16% and 30%, and 37 had fewer than 16%, including 8 with none. There were significantly more PGY-1 than PGY-7 female residents (28.9% vs 16.4%, p < 0.01). Programs with ACGME accreditation before 1970 had significantly higher percentages of female residents (26.0%) compared with those accredited after 1970 (18.2%, p < 0.01). Program size was associated with a higher percentage of female residents (large = 25.2%, medium = 24.9%, and small = 19.6%), although the results were not significant. The distribution of female trainees across five geographic regions of the United States was fairly even: Northeast (24.5%), West (25.2%), South Atlantic (23.1%), South Central (21.8%), and North Central (21.2%). Residency acceptance rates were similar between genders.
    CONCLUSIONS: The underrepresentation of women in neurosurgery residency programs remains a significant issue. While some programs have achieved higher female representation than the overall average proportion of female neurosurgery residents, many still fall short. There are twice as many female PGY-1 compared with PGY-7 residents, suggesting increased recruitment over the past few years. Programs with longer accreditation histories have significantly higher proportions of female residents. Larger program size can also play a role in attracting more female residents, but geographic location did not impact gender composition of resident cohorts in this study.
    Keywords:  gender diversity; neurosurgery residents; program characteristics
    DOI:  https://doi.org/10.3171/2023.8.FOCUS23442
  63. Front Public Health. 2023 ;11 1235164
      Objective: This portfolio analysis aims to describe the scope of NIH-funded extramural research grants at the intersection of nutrition research and implementation science (IS) from 2011 to 2022 and to offer insights into future research opportunities relevant to the Strategic Plan for NIH Nutrition Research 2020-2030.Methods: A portfolio analysis of funded grants using NIH reporting systems was conducted to identify nutrition research and IS awarded between fiscal years 2011 and 2022. The authors screened the titles and abstracts for inclusion criteria: research and career development awards involved a nutrition and/or dietary intervention and measured a stated implementation outcome or used an IS theory, model, or framework.
    Results: In total, 33 NIH-funded awards met the inclusion criteria. Almost half of the awards (48.5%) were investigator-initiated research projects compared to research career awards and cooperative agreements. While studies were predominantly conducted in the United States, 15.2% were conducted in low- and middle-income countries in Africa, Latin America, and Asia. Adults aged 19-64 years and children aged 2-11 years represented most of the study populations (45.5 and 15.2%, respectively). Studies provided nutrition/dietary guidelines and created culturally tailored interventions, which were then adapted in collaboration with community partners in schools, hospitals, and religious settings. The most cited IS outcomes were feasibility, costs, adoption, and acceptability. Sixteen awards (48.5%) used an IS theory, model, or framework to guide their work.
    Discussion: The findings show the breadth of NIH-funded nutrition and implementation research and highlight potential research opportunities.
    Keywords:  NIH; grants; implementation science; nutrition; research
    DOI:  https://doi.org/10.3389/fpubh.2023.1235164
  64. Cureus. 2023 Oct;15(10): e46303
      Patient-reported outcome measures (PROMs) are standardized tools commonly applied in research and healthcare appraisal. Most were developed in English and the cross-cultural adaptation (CCA) and validation of their translated versions remain topics of contemporary research appeal. This review aimed to identify the Arabic-translated PROMs that were utilized in spine research and to assess the methodological qualities of their studies. The PubMed database was searched, and all relevant publications were identified. The CCA and measurement properties were assessed using the guidelines described by Oliveria and Terwee respectively. Thirty studies that validated the Arabic versions of 26 PROMs were found suitable. The tools that had the highest total citation numbers were Neck Disability Index, Ronald-Morris Disability Questionnaire, Oswestry Disability Index, Fear Avoidance Beliefs Questionnaire, Scoliosis Research Society-22, Back Beliefs Questionnaire, Quebec Back Pain Disability Scale, and McGill Pain Questionnaire-Short Form. The Arabic versions of Short Form-36 (SF-36), Visual Analogue Scale (VAS), and EuroQol-5D (EQ-5D) were not included due to lack of validation in spine research. All the articles were published from 2007 to 2023 (median 2019) and their journal's impact factor and citation numbers were relatively modest (mean 2 and 6.5 respectively). Most patients had low back pain (19 articles), were recruited from physiotherapy and rehabilitation departments (18 articles) and came from the Kingdom of Saudi Arabia (12 articles). The quality of the CCA of the Arabic versions was rated good in forward translation, synthesis, back translation, and expert committee review but less so in pretesting and submission. The measurement properties of the studies were considered good quality in internal consistency, reliability, structural validity and cross-cultural validity but less so in content validity, error measurement, responsiveness and floor/ceiling effect. In conclusion, with a few exceptions, most of the widely utilized PROMs in spine research have validated Arabic versions. The methodological quality of the studies was good apart from a few shortages that could be improved upon by further research. Work should be done to address the validation of Arabic versions of SF-36, VAS and EQ-5D in spine research. PROMs are valuable in systematizing subjective outcomes. Their usage in research and clinical settings in any validated language should be highly encouraged.
    Keywords:  arabic; cross-cultural adaptation; measurement properties; patient-reported outcome measures; proms; reliability; surveys and questionnaires; translation; validity
    DOI:  https://doi.org/10.7759/cureus.46303