bims-evares Biomed News
on Evaluation of research
Issue of 2024‒08‒04
76 papers selected by
Thomas Krichel, Open Library Society
  1. Frontiers in premature beats research: a bibliometric analysis.
  2. Trends and hot spots in research related to aqueous humor from 2014 to 2023: A bibliometric analysis.
  3. Bibliometric Analysis of Machine Learning Applications in Ischemia Research.
  4. Analysis of the Formation of Scientific Communities in the Journal Research and Education in Nursing (2010 - 2020) and its Disciplinary Influence: an Approach from Bibliometric Analysis, Network Analysis, and Natural Language Processing.
  5. The research hotspots and theme trends of artificial intelligence in nurse education: A bibliometric analysis from 1994 to 2023.
  6. Mapping knowledge structure and emerging trends of extracorporeal membrane oxygenation for acute respiratory distress syndrome: a bibliometric and visualized study.
  7. A Comprehensive Overview of the Stellate Ganglion Block Throughout the Past Three Decades: A Bibliometric Analysis.
  8. The 100 highest-cited original articles in large vessel occlusions: A bibliometric analysis.
  9. Analysis of scientific publications on oral cancer diagnosis delays: a bibliometric study over 22 years.
  10. Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023.
  11. Association between obesity and liver cancer from 2012 to 2023: Bibliometric analysis and global trends.
  12. Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis.
  13. Bibliometric analysis of neuroinflammation and Alzheimer's disease.
  14. A Bibliometric Analysis of Clear Aligner Treatment (CAT) From 2003 to 2023.
  15. Recurrent Pregnancy Loss: A Bibliometric Review.
  16. Trend of albumin nanoparticles in oncology: a bibliometric analysis of research progress and prospects.
  17. Indias Publications on Rheumatoid Arthritis: A Bibliometric Analysis of Research Output from 1994 to 2023 A.D.
  18. Bibliometric analysis of scientific production on university social responsibility in Latin America and the Caribbean.
  19. Research trends and hotspots for frontotemporal dementia from 2000 to 2022: a bibliometric analysis.
  20. Research landscape of genetics in dilated cardiomyopathy: insight from a bibliometric analysis.
  21. Research trends and hotspots in the immune microenvironment related to hepatocellular carcinoma: A bibliometric and visualization study.
  22. Medication-Related Osteonecrosis of the Jaw: Bibliometric Analysis from 2003 to 2023.
  23. Endophthalmitis: a bibliometric study and visualization analysis from 1993 to 2023.
  24. Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study.
  25. Exploring the landscape of extracellular vesicle application for skin and plastic surgery: A bibliometric analysis from 2003 to 2023.
  26. Global research trends on gut microbiota and metabolic dysfunction-associated steatohepatitis: Insights from bibliometric and scientometric analysis.
  27. Metabolic reprogramming in hepatocellular carcinoma: a bibliometric and visualized study from 2011 to 2023.
  28. Knowledge mapping of hyperbaric oxygen therapy in sudden sensorineural hearing loss: A bibliometric analysis (2015-2024).
  29. Infectious disease research in the Association of Southeast Asian Nations region: a scientometric analysis.
  30. Bibliometric Analysis and Visualization of Scientific Literature on Heart Disease Classification Using a Logistic Regression Model.
  31. Artificial intelligence applications in dentistry: A bibliometric review with an emphasis on computational research trends within the field.
  32. Bibliometric Analysis of Alzheimer's Disease and Depression.
  33. Explanatory Note - CiteScore Versus Impact Factor.
  34. Global research on emerging trends of obstetrics during the COVID-19 pandemic: A bibliometric analysis.
  35. The changes in zoological publication rates and focal subdisciplines between 1960 and 2022.
  36. Mapping the global research landscape on depression for patients with chronic kidney disease: a bibliometric and visualized analysis from 2006 to 2022.
  37. An in-depth analysis of membrane distillation research (1990-2023): Exploring trends and future directions through bibliometric approach.
  38. Most Cited Articles in 2023.
  39. Visual analysis of abdominal aortitis treatment using the CiteSpace bibliometric method.
  40. A One Health information database based on standard bibliometric analysis.
  41. Unveiling the global reach of African anthrax research: A bibliometric study.
  42. Assessing sex and gender equity in submission guidelines of radiology journals: A cross-sectional study.
  43. Spiritual Care in Palliative Medicine and End of Life: A Bibliometric Network Analysis.
  44. Prominent themes in shoulder dystocia research: A bibliometric and document-based analysis.
  45. Analysis of the citation impact of Brazilian researchers in oral pathology and oral medicine over two decades.
  46. Journal Citation Report 2024 and Impact Factor of Pakistani Biomedical Journals: Grading impact and analysis.
  47. Immunotherapy and liver cancer research trends and the 100 most cited articles: A bibliometric analysis.
  48. Knowledge domains and emerging trends in non-invasive brain stimulation: A bibliometric analysis via CiteSpace
  49. Study on the Analysis of Gender Trends Among the First Authors of Publications on Budd-Chiari Syndrome.
  50. Thirteen Years JDST: A Quite Nice Ride.
  51. Global research trends and frontiers in regulatory T cells within ovarian cancer: A bibliometric and visual analysis.
  52. The interaction between liver cancer and intestinal microbiome: Global research status and trends.
  53. Geographical Trends in Global Ophthalmology Research from 2002-2022.
  54. Antibody-drug conjugates for breast cancer: a bibliometric study and clinical trial analysis.
  55. Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer.
  56. Academic and Demographic Profile of Orthopaedic Vice Chairs of Research: Implications for Leadership.
  57. Academic Citation Partnership: A Predatory Practice that Undermines Scholarly Integrity.
  58. Global Landscape of Platelet-Rich Plasma Research in Medical Dermatology: A Visualized Bibliometric Analysis (2004-2023).
  59. Profile of scientific production on nursing technology construction, validity and application: a bibliometric study.
  60. Comment on "What predicts citation counts and translational impact in headache research? A machine learning analysis".
  61. Cultural and multicultural topics in Neuropsychology Journal titles from 2010-2020.
  62. Bibliometric study and potential applications in the development of starch films with nanocellulose: A perspective from 2019 to 2023.
  63. Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing.
  64. Brain and spine has an impact factor.
  65. The impact of a curriculum-based research training program on medical students' research productivity and future research interests: a longitudinal study.
  66. A memory-theoretic account of citation propagation.
  67. Democratizing neurosurgical knowledge: a call for publishing reform.
  68. A bibliometric analysis of immune-related adverse events in cancer patients and a meta-analysis of immune-related adverse events in patients with hepatocellular carcinoma.
  69. Combining Bibliometric Analysis to Uncover the Detrimental and Protective Roles of Various Dendritic Cell Types in Cardiovascular Arterial Diseases.
  70. Publication Status of Theses among Post-graduate Students in Nursing from Institute of Medicine.
  71. Editorial: Women in oral health promotion.
  72. Editors' Selections from Relevant Scientific Publications.
  73. Characteristics and Impact of Randomized Trials on Drugs or Devices in Cardiovascular Medicine.
  74. Estimating the Use of ChatGPT in Dental Research Publications.
  75. These AI firms publish the world's most highly cited work.
  76. Bibliometric Patent Review of Minimally Invasive Spine Surgery.
  1. Front Cardiovasc Med. 2024 ;11 1343274
    Frontiers in premature beats research: a bibliometric analysis.
    Dan Wu, Xiaojing Xia.
      Background: This study aimed to assess the scientific results and activities of premature beats research from a global perspective.Methods: Publications related to premature beats published between 2003 and 2024 were identified and selected from the Web of Science core collection. VOSviewer was used to conduct co-authorship, co-citation, and co-occurrence analyses of the authors, organizations, countries/regions, references, sources, cited authors, and keywords.
    Results: In total, 5,283 publications on the topic of premature beats were identified from the Web of Science core collection. The number of publications on this topic has steadily grown since 2003. Fred Morady, Frank Bogun and Krit Jongnarangsin were the top three researchers with the strongest total link strengths. The University of Washington, Johns Hopkins University, and the University of Minnesota are the top three organizations with the strongest total link strengths. The United States has made the greatest contributions to the field of premature beats. Haïssaguerre, M et al.'s publication in The New England Journal of Medicine in 1998 entitled "Spontaneous initiation of atrial fibrillation by ectopic beats originating in the pulmonary veins" is the most cited reference. The most cited references come from the journal named Circulation. Haïssaguerre, M has the highest number of citations. The keywords for all current publications can be divided into four categories: "mortality rate," "risk and prevention," "mechanism," and "classification and treatment."
    Conclusions: This bibliometric study provides insights into the current status and research trends in premature beats over more than 20 years. Future research will focus on an in-depth exploration of the nature of premature beats, especially ventricular premature beats, mastering the development law of premature beats, and optimizing existing detection methods.
    Keywords:  VOSviewer; arrhythmia; premature beats; ventricular premature beats; visualization
    DOI:  https://doi.org/10.3389/fcvm.2024.1343274
  2. Heliyon. 2024 Jul 15. 10(13): e33990
    Trends and hot spots in research related to aqueous humor from 2014 to 2023: A bibliometric analysis.
    Weichen Yuan, Xin Xu, Fangkun Zhao.
      Purpose: To analyze publication trends and investigate research hotspots of aqueous humor (AH) studies.Methods: A bibliometric study was conducted based on the Web of Science Core Collection (WOSCC). VOSviewer v. 1.6.18 was utilized to create a knowledge map visualizing the number of annual publications, the distribution of countries, international collaborations, author productivity, source journals and keywords in the field.
    Results: A grand total of 4020 peer-reviewed papers concerning AH were retrieved from 2014 to 2023. The United States of America secured the top position among the most published countries and Duke University emerged as the most active institution. Stamer, WD contributed the most papers in this area. Investigative Ophthalmology & Visual Science was the most prolific journal in AH research. Retrieved publications mainly concentrated on the correlation between AH as a biomarker carrier and different ocular disorders. Six clusters were formed based on the keywords: (1) the diagnosis of endophthalmitis and AH pharmacokinetics; (2) the association of AH with pathogenesis and prognosis of glaucoma; (3) diagnosis and treatment of AH associated with uveitis; (4) the relationship between AH and refractive diseases of the eye; (5) the association of AH with mechanism and biomarkers of ocular tumorigenesis; (6) the indicators of AH associated with fundus disease.
    Conclusions: This study unveiled present patterns of global collaboration, emerging frontiers, fundamental knowledge, research hotspots and current trends in AH.
    Keywords:  Aqueous humor; Bibliometric; Biomarkers; Body fluid; Glaucoma
    DOI:  https://doi.org/10.1016/j.heliyon.2024.e33990
  3. Curr Probl Cardiol. 2024 Jul 28. pii: S0146-2806(24)00391-8. [Epub ahead of print] 102754
    Bibliometric Analysis of Machine Learning Applications in Ischemia Research.
    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Hassan Ahmad Alfaifi, Abdullah Farasani, Waseem Hassan.
      OBJECTIVE: The objective of this study is to conduct a comprehensive bibliometric analysis to elucidate the landscape of machine learning applications in ischemia research.METHODS: The analysis can be divided in three sections: part 1 scrutinizes articles and reviews with "ischemia" in their titles, while part 2 further narrows the focus to publications containing both "ischemia" and "machine learning" in their titles. Additionally, part 3 delves into the examination of the top 50 most cited papers, exploring their thematic focus and co-word dynamics.
    RESULTS: The findings reveal a significant increase in publications over the years, with notable trends identified through detailed analysis. The growth in publication counts over time, the leading contributors, institutions, geographical distribution of research output and journals are numerically presented for part 1 and part 2. For the top 50 most cited papers the dynamics of co-words, which offer a nuanced understanding of thematic trends and emerging concepts, are presented. Based on the number of citations the top 10 authors were selected, and later for each, total number of publications, h-index, g-index and m-index are provided. Additionally, figures depicting the co-authorship network among authors, departments, and countries involved in the top 50 cited papers may enrich our comprehension of collaborative networks in ischemia research.
    CONCLUSION: This comprehensive bibliometric analysis provides valuable insights into the evolving landscape of machine learning applications in ischemia research.
    Keywords:  Bibliometric Analysis; Ischemia; Machine Learning; Scopus
    DOI:  https://doi.org/10.1016/j.cpcardiol.2024.102754
  4. Invest Educ Enferm. 2024 Jun;42(2):
    Analysis of the Formation of Scientific Communities in the Journal Research and Education in Nursing (2010 - 2020) and its Disciplinary Influence: an Approach from Bibliometric Analysis, Network Analysis, and Natural Language Processing.
    Andrés Guzmán Henao.
      Objective: This work sought to identify the academic communities that have shown interest and participation in the Journal Research and Education in Nursing and analyze the scientific impact generated by said journal.Methods: A bibliometric analysis was carried out, as well as social network analysis and techniques of natural language processing to conduct the research. The data was gathered and analyzed during a specific study period, covering from 2010 - 2020, for articles published in the journal, and 2010 - 2022, for articles that cited the journal within Scopus. These methods permitted performing an exhaustive evaluation of the journal's influence and reach in diverse academic and geographic contexts.
    Results: During the analysis, it was noted that the journal Research and Education in Nursing has had significant influence in academic and scientific communities, both nationally and internationally. Collaboration networks were detected among diverse institutions and countries, which indicates active interaction in the field of nursing research. In addition, trends and emerging patterns were identified in this field, providing a more complete view of the discipline's evolution.
    Conclusion: Based on the results obtained, it is concluded that the journal Research and Education in Nursing has played un fundamental role in disseminating knowledge and promoting research in nursing. The combination of Bibliometric metrics, social network analysis, and natural language processing permitted utmost comprehension of its impact in the scientific and academic community globally.
    Keywords:  academic impact; bibliometric metrics; natural language processing; research and education in nursing; scientific collaboration; social network analysis
    DOI:  https://doi.org/10.17533/udea.iee.v42n2e12
  5. Nurse Educ Today. 2024 Jul 26. pii: S0260-6917(24)00231-4. [Epub ahead of print]141 106321
    The research hotspots and theme trends of artificial intelligence in nurse education: A bibliometric analysis from 1994 to 2023.
    Chuhong Luo, Bin Mao, Ying Wu, Ying He.
      OBJECTIVES: To explore research hotspots and theme trends in artificial intelligence in nurse education using bibliometric analysis.DESIGN: Bibliometric analysis.
    DATA SOURCES: Literature from the Web of Science Core Collection from the time of construction to October 31, 2023 was searched.
    REVIEW METHODS: Analyses of countries, authors, institutions, journals, and keywords were conducted using Bibliometrix (based on R language), CiteSpace, the online analysis platform (bibliometric), Vosviewer, and Pajek.
    RESULTS: A total of 135 articles with a straight upward trend over the last three years were retrieved. By fitting the curve R2 = 0.6022 (R2 > 0.4), we predicted that the number of annual articles is projected to grow in the coming years. The United States (n = 38), the National University of Singapore (n = 16), Professor Jun Ota (n = 8), and Nurse Education Today (n = 14) are the countries, institutions, authors, and journals that contributed to the most publications, respectively. Collaborative network analysis revealed that 32 institutional and 64 author collaborative teams were established. We identified ten high-frequency keywords and nine clusters. We categorized the research hotspots of artificial intelligence in nurse education into three areas: (1) Artificial intelligence-enhanced simulation robots, (2) machine learning and data mining, and (3) large language models based on natural language processing and deep learning. By analyzing the temporal and spatial evolution of keywords and burst detection, we found that future research trends may include (1) expanding and deepening the application of AI technology, (2) assessment of behavioral intent and educational outcomes, and (3) moral and ethical considerations.
    CONCLUSIONS: Future research should be conducted on technology applications, behavioral intent, ethical policy, international cooperation, interdisciplinary cooperation, and sustainability to promote the continued development and innovation of AI in nurse education.
    Keywords:  Artificial intelligence; Bibliometric analysis; Nurse education; Nursing students
    DOI:  https://doi.org/10.1016/j.nedt.2024.106321
  6. Front Med (Lausanne). 2024 ;11 1365864
    Mapping knowledge structure and emerging trends of extracorporeal membrane oxygenation for acute respiratory distress syndrome: a bibliometric and visualized study.
    Yanqiu Lu, Wanqing Li, Shaoyan Qi, Kunming Cheng, Haiyang Wu.
      Introduction: With the discovery of extracorporeal membrane oxygenation (ECMO), it is considered as a valuable tool for supporting the treatment of severe acute respiratory distress syndrome (ARDS). It has gained increasing attention, particularly during the COVID-19 epidemic. However, to date, no relevant bibliometric research on the association between ECMO and ARDS (ECMO-ARDS) has been reported. Our study aimed to summarize the knowledge structure and research focus of ECMO-ARDS through a bibliometric analysis.Method: Publications related to ECMO-ARDS from 2000 to 2022 were obtained from the Web of Science Core Collection (WoSCC). Research data underwent bibliometric and visual analysis by using CiteSpace, VOSviewer, and one online analysis platform. By analyzing the countries, institutions, journals, authors, the geographic distribution of research contributions as well as the leading institutions and researchers in this field were identified. Additionally, prominent journals and highly cited publications were highlighted, indicating their influence and significance in the field. Moreover, the co-citation references and co-occurring keywords provided valuable information on the major research topics, trends, and potential emerging frontiers.
    Results: A total of 1,565 publications from 60 countries/regions were retrieved. The annual publication number over time revealed exponential growth trends (R2 = 0.9511). The United States was dominant in ECMO-ARDS research, whereas the Univ Toronto was most productive institution. Prof Combes A published the most publications in this area. ASAIO Journal and Intensive Care Medicine were the most active and co-cited journals, respectively. Reference co-citation analysis showed that current research focus has shifted to COVID-related ARDS, multi-center studies, as well as prone positioning. Apart from the keywords "ECMO" and "ARDS", other keywords appearing at high frequency in the research field were "COVID-19", "mechanical ventilation", "extracorporeal life support", "respiratory failure", "veno-venous ECMO", "SARS-CoV-2", "outcome". Among them, keywords like "mortality", "veno-venous ECMO", "epidemiology", "obesity", "coagulopathy", "lung ultrasound", "inhalation injury", "noninvasive ventilation", "diagnosis", "heparin", "cytokine storm" has received growing interest in current research and also has the potential to continue to become research hotspots in the near future.
    Conclusion: This bibliometric analysis offers a comprehensive understanding of the current state of ECMO-ARDS research and can serve as a valuable resource for researchers, policymakers, and stakeholders in exploring future research directions and fostering collaborations in this critical field.
    Keywords:  ECMO; acute respiratory distress syndrome; bibliometrics; hotspots; visualization
    DOI:  https://doi.org/10.3389/fmed.2024.1365864
  7. Pain Physician. 2024 Jul;27(5): E597-E610
    A Comprehensive Overview of the Stellate Ganglion Block Throughout the Past Three Decades: A Bibliometric Analysis.
    Ying Ren, Zhen Zhang, Hong-Ping Li, Peng-Ju Zhang, Jietai Duo, Hao Kong.
      BACKGROUND: Over the past 3 decades, clinicians and scholars have used and studied the stellate ganglion block (SGB) extensively, making this field a highly anticipated research hot spot. To the best of our knowledge, there has been no bibliometric analysis of the SGB until now.OBJECTIVE: Our study aimed to complete multiple tasks regarding SGB research: identify the collaboration and impact of countries, institutions, journals, and authors, evaluate the knowledge base, trace the trends in hot spots, and explore the emerging topics relevant to the field.
    STUDY DESIGN: A bibliometric analysis.
    METHODS: Publications that were associated with the SGB and published between the years of 1993 and 2022 were retrieved from the Web of Science Core Collection on September 21st, 2023. CiteSpace 6.1.R6 and VOSviewer 1.6.18 were used to perform bibliometric and knowledge-map analyses.
    RESULTS: This study found a total of 837 publications originating from 51 countries and 1006 institutions. These articles were published in 393 journals. The United States was the country that produced the most articles focused on SGB, and the University of California, Los Angeles was the institution associated with the greatest number of publications. The anesthesiology and cardiology journals surveyed for this study published the most articles and received the most citations. Among the authors whose works were examined, Kitajima T had the greatest number of published articles, and Lipov E was the most frequently cited co-author. Five main domains of SGB research included electrical storm and refractory ventricular arrhythmia, breast cancer and climacteric medicine, post-traumatic stress disorder, pain management, and cerebrovascular diseases. The latest hot topics involving this field focused on SGB's anti-arrhythmic and anti-cerebral vasospasm effects and its treatment of long COVID syndrome.
    LIMITATIONS: Data were retrieved only from the WoSCC; therefore, publications in other databases might have been missed.
    CONCLUSION: This comprehensive bibliometric analysis conducted a complete overview of SGB research, which was helpful in furthering our understanding of research trends and locating research hot spots and gaps in this domain. This field is developing rapidly and will garner significant and continuous attention from future scholars.
    Keywords:   CiteSpace; VOSviewer; bibliometric; electrical storm; hot flashes ; knowledge-map; post-traumatic stress disorder; Stellate ganglion block
  8. Neuroradiol J. 2024 Aug 01. 19714009241269503
    The 100 highest-cited original articles in large vessel occlusions: A bibliometric analysis.
    Ataollah Shahbandi, Matthew Holt, Nathan A Shlobin.
      BACKGROUND: Large vessel occlusions (LVO) are a common etiology of morbidity and mortality. The current literature lacks a synthesis of the landscape and trends in research.OBJECTIVE: We aimed to conduct a bibliometric analysis of the 100 most cited original articles on LVOs to assess the current state of research.
    METHODS: Scopus database was queried from inception to December 2022 to identify the most cited original articles from 4506 retrieved records on LVOs. Publication year, country of origin, total and average annual citation count, and type of study were collected for each article. The journal impact factor (JIF) was obtained from the Journal Citation Reports database.
    RESULTS: The articles were published between 1994 and 2021, with most (n = 82) published during the 2011-2020 decade. The median total citation count was 108.5, with an interquartile range (IQR) of 81-149.5. The median (IQR) average annual citation count was 15.9 (11.5-22.9). Half of the articles were published in Stroke (n = 35) and Journal of NeuroInterventional Surgery (n = 15), with JIFs ranging from 1.8 to 202.7. The USA was the leading country in contributing to LVO research (n = 45). Most studies focused on the treatment (n = 63) and diagnosis (n = 22) of LVOs.
    CONCLUSIONS: Most articles were published during the past decade, highlighting the impact of the clinical trials of endovascular treatment on the discipline. With several ongoing clinical trials on the horizon, continued growth of the field is anticipated in the upcoming decades.
    Keywords:  Endovascular; large arterial occlusion; large artery occlusion; large vessel occlusion; stroke; thrombectomy
    DOI:  https://doi.org/10.1177/19714009241269503
  9. Med Oral Patol Oral Cir Bucal. 2024 Aug 01. pii: 26719. [Epub ahead of print]
    Analysis of scientific publications on oral cancer diagnosis delays: a bibliometric study over 22 years.
    L-J Lisboa, A-L Pires, A-M Silva, V-S Freitas.
      BACKGROUND: The area of oncology still lacks bibliometric studies that investigate the diagnostic interval of oral cancer. This study proposed to carry out a bibliometric analysis of epidemiological studies that investigated the diagnosis of oral cancer between 2002 to 2024.MATERIAL AND METHODS: On April, 2024, the Scopus and Web of Science databases were explored, and the selected articles underwent bibliometric analysis of performance and scientific mapping of journals, authors, institutions, and countries, as well as the predominant topics and trends in research into the diagnosis of oral cancer through an analysis of references and co-occurrence of key words. The analyzes were carried out using the R extension package, Bibliometrix, and the VOSviewer software.
    RESULTS: A total of 532 documents were included. China contributed the highest number of publications (36.71%) and total citations [1,584]. Seoane J was the most prolific author [16 (h-index: 9)], while Warnakulasuriya S had the highest total link strength [282 (h-index: 7)] in co-citations. Oral Oncology was identified as the most prolific [231 (72.64%)], co-cited and impactful journal (h-index: 13). Explosions of citations were found for keywords such as "early diagnosis", "biomarker", "saliva", "precancer" and "prognosis", making it evident that in the field of oral cancer diagnosis there is room for new studies focusing in reducing the diagnostic interval, with the research hotspots being the terms "biomarkers", "imaging diagnosis" and "gene expression".
    CONCLUSIONS: This study provides valuable information that can help researchers and institutions align their research activities according to emerging themes, establish collaborations and allocate resources effectively.
    DOI:  https://doi.org/10.4317/medoral.26719
  10. Front Pharmacol. 2024 ;15 1445061
    Bibliometric analysis of vitamin D and obesity research over the period 2000 to 2023.
    Xudong Song, Senhua Qin, Shuxin Chen, Can Zhang, Lin Lin, Ziyi Song.
      Background: Globally, the incidence rates of obesity and its related diseases, such as cardiovascular diseases and type 2 diabetes, are continuously rising, posing a significant public health challenge. Studies have indicated a potential correlation between vitamin D deficiency and obesity. However, a quantitative analysis of the studies related vitamin D and obesity is lacking. This investigation aims to fill this gap by providing a comprehensive bibliometric analysis to uncover the collaborative networks, research hotspots, and evolutionary trends within the field of vitamin D and obesity research.Methods: This study retrieved literature related to vitamin D and obesity from the Web of Science database spanning from 2000 to 2023. Bibliometric analysis was conducted using tools such as HistCite, VOSviewer, and CiteSpace to excavate multi-dimensional information including countries, institutions, authors, journals, citations, and keywords.
    Results: A total of 6,144 records were retrieved, involving 123 countries, 6,726 institutions, and 28,156 authors, published in 1,551 journals. The number of published papers and citations showed a generally increasing trend. The United States led in terms of publication volume and influence, with journals such as Nutrients and Obesity Surgery having the highest publication counts. Nasser M. Al-Daghri was the most prolific and influential author. Keyword clustering revealed that research topics covered metabolic health, nutrition, immunity, and bariatric surgery. Citation burst analysis indicated a shift in research focus from the relationship between dietary calcium and obesity to the preventive effects of vitamin D supplementation on metabolic diseases.
    Conclusion: The application of bibliometric methods to analyze the research literature in the fields of obesity and vitamin D has provided a comprehensive understanding of the collaborative networks, key research focus, and evolutionary trends in this field, offering insights for guiding future research directions.
    Keywords:  bibliometric analysis; obesity; trends; vitamin D; vitamin D deficiency
    DOI:  https://doi.org/10.3389/fphar.2024.1445061
  11. Medicine (Baltimore). 2024 Aug 02. 103(31): e39167
    Association between obesity and liver cancer from 2012 to 2023: Bibliometric analysis and global trends.
    Donghong Wang, Zhibin Ma.
      Incidence rates of liver cancer have increased worldwide in recent decades, making it a major public health problem globally. Obesity can be caused by multiple factors and promotes the development of liver cancer in many ways. Although the research on the association between obesity and liver cancer was previously explored, we first employed bibliometrics to analyze the current research status. From 2012 to 2023, the Web of Science Core Collection database was searched for studies regarding the association between obesity and liver cancer. To evaluate worldwide trends and research hotspots in this topic, bibliometric analysis tools such as VOSviewer, CiteSpace, and R Package were employed. Altogether 233 eligible publications, consisting of 167 articles and 66 reviews, were analyzed. The yearly number of publications and average citation numbers have increased over the last 11 years, particularly the last 6 years. The great majority of published articles on this topic originated from the United States (n = 89, 38.20%), followed by China (n = 60, 25.75%), and England (n = 23, 9.87%). In this subject's research, American scholars embodied considerable production, great prominence, and high academic influence. The most cited article was Yoshimoto, S et al of Japan Science and Technology Agency published in 2013 with a citation number of 1410. We apply bibliometric analysis for the first time in this field, expecting to help scholars efficiently and effectively retrieve the association between obesity and liver cancer.
    DOI:  https://doi.org/10.1097/MD.0000000000039167
  12. World J Clin Cases. 2024 Jul 26. 12(21): 4726-4741
    Trends and frontiers in signal amplification for aptamer-based tumor detection: A bibliometric analysis.
    Dan Cai, Gui-Lin Chen, Ting Wang, Kun-He Zhang.
      BACKGROUND: Malignant tumors are one of the leading causes of death worldwide, imposing a substantial economic and social burden. Early detection is the key to improving cure rates and reducing mortality rates, which requires the development of sensitive early detection technologies. Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.AIM: To investigate the current research status, developmental trajectories, and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis.
    METHODS: English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace software were employed to analyze various information within this field, including countries, institutions, authors, co-cited authors, journals, co-cited journals, cited references, and keywords.
    RESULTS: A total of 757 publications were included in this study. China accounted for 85.47% of all publications, with Nanjing University (China) emerging as the institution with the highest publication output. The most influential authors and journals were Hasanzadeh M. from Iran and "Biosensors and Bioelectronics", respectively. Exosomes and carcinoembryonic antigen (CEA) stood out as the most researched tumor-related molecules. Currently, the predominant signal amplification technique, nanomaterial, and signal transduction method were identified as hybridization chain reactions, gold nanoparticles, and electrochemical methods, respectively. Over the past 3 years, exosomes, CEA, electrochemical biosensors, and nanosheets have emerged as research hotspots, exhibiting a robust burst of intensity.
    CONCLUSION: This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status, hotspots, and prospective research directions within this realm. Additionally, it provides an important reference for researchers.
    Keywords:  Aptamer; Bibliometrics; Electrochemistry; Nanosheet; Signal amplification; Tumor
    DOI:  https://doi.org/10.12998/wjcc.v12.i21.4726
  13. Front Aging Neurosci. 2024 ;16 1423139
    Bibliometric analysis of neuroinflammation and Alzheimer's disease.
    Wenxian Sun, Jin Gong, Shaoqi Li, Pin Wang, Xiaodong Han, Chang Xu, Heya Luan, Ruina Li, Boye Wen, Cuibai Wei.
      Background: Alzheimer's disease (AD) is the predominant cause of dementia on a global scale, significantly impacting the health of the elderly population. The pathogenesis of AD is closely linked to neuroinflammation. The present study employs a bibliometric analysis to examine research pertaining to neuroinflammation and AD within the last decade, with the objective of providing a comprehensive overview of the current research profile, hotspots and trends.Methods: This research conducted a comprehensive review of publications within the Science Citation Index Expanded of the Web of Science Core Collection Database spanning the years 2014 to 2024. Bibliometric analyses were performed using VOSviewer (version 1.6.19) and CiteSpace (version 6.3.R1) software to visualize data on countries, institutions, authors, journals, keywords, and references.
    Results: A total of 3,833 publications on neuroinflammation and AD were included from January 2014 to January 2024. Publications were mainly from the United States and China. Zetterberg, Henrik emerged as the author with the highest publication output, while Edison, Paul was identified as the most cited author. The most productive journal was Journal of Alzheimers Disease, and the most co-cited was Journal of Neuroinflammation. Research hotspot focused on microglia, mouse models, oxidative stress, and amyloid-beta through keyword analysis. Additionally, keywords such as blood-brain barrier and tau protein exhibited prolonged citation bursts from 2022 to 2024.
    Conclusion: This study provides a comprehensive review of the last 10 years of research on neuroinflammation and AD, including the number and impact of research findings, research hotspots, and future trends. The quantity of publications in this field is increasing, mainly in the United States and China, and there is a need to further strengthen close cooperation with different countries and institutions worldwide. Presently, research hotspots are primarily concentrated on microglia, with a focus on inhibiting their pro-inflammatory responses and promoting their anti-inflammatory functions as a potential direction for future investigations.
    Keywords:  Alzheimer’s disease; CiteSpace; VOSviewer; bibliometrics; microglia; neuroinflammation
    DOI:  https://doi.org/10.3389/fnagi.2024.1423139
  14. Cureus. 2024 Jun;16(6): e63348
    A Bibliometric Analysis of Clear Aligner Treatment (CAT) From 2003 to 2023.
    Xian He, Zeyu Huang, Yi Yang, Xuechun Yuan, Shangyou Wen, Yuetian Li, Guannan Hu, Wenli Lai, Hu Long.
      Clear aligner treatment (CAT) has been evolving over the past two decades. This study aims to conduct a comprehensive and up-to-date bibliometric analysis of publications related to CAT, presenting the research trends, landscapes, and hot spots in this field. All publications were retrieved from the Web of Science Core Collection from 2003 to 2023. In addition to a general analysis of research landscapes, the following items were analyzed, i.e., countries, institutions, authors, journals, publications, and keywords. A total of 1031 relevant publications were included in this study. From 2003 to the present, the number of publications and citations in this field showed an increasing trend. Italy led in terms of publication counts, and Sichuan University in China had the highest publication counts among institutions. In total, 33 scholars had published a minimum of 10 articles, and the collaborations among them were mostly within each country. The American Journal of Orthodontics and Dentofacial Orthopedics published the most relevant publications. "Predictability of tooth movements," "influencing factors for clinical efficacy," "biomechanics," and "patients' perception and periodontal health" stood out as the core research focus on CAT. Our study identified the most influential countries, institutions and authors, and their cooperative relationships, and detected hot research topics on CAT, calling for more high-quality international collaborative research in the future.
    Keywords:  bibliometric analysis; clear aligner treatment; data visualization; orthodontics; research status
    DOI:  https://doi.org/10.7759/cureus.63348
  15. Iran J Public Health. 2024 Jul;53(7): 1629-1639
    Recurrent Pregnancy Loss: A Bibliometric Review.
    Zahra Panahi, Razieh Akbari, Marjan Ghaemi.
      Background: The research combined different bibliometric techniques to analyze systematically recurrent pregnancy loss (RPL) documents from 1970 to 2023.Methods: Overall, 1287 documents from the Web of Science database associated with recurrent pregnancy loss between 1970 and 2023 were identified for more than 300 journals. The data were analyzed with VOSviewer software.
    Results: The trend of paying attention to the topic of RPL can be divided into three periods. The number of publications on RPL increased significantly after 2010. Most of the papers were published in Obstetrics and Gynecology and Reproductive Biology areas. Utilizing co-occurrence and co-citation analysis, our study found that the most influential documents mapped the knowledge structure, and projected future research directions. The co-occurrence analysis showed five clusters even though the co-citation analysis designates four.
    Conclusion: RPL has increased in recent years exponentially and some areas were explained carefully, therefore these results could be used as a research agenda for the future direction by a range of interested beneficiaries.
    Keywords:  Bibliometric; Co-citation; Co-occurrence; Recurrent pregnancy loss; Web of science database
    DOI:  https://doi.org/10.18502/ijph.v53i7.16057
  16. Front Pharmacol. 2024 ;15 1409163
    Trend of albumin nanoparticles in oncology: a bibliometric analysis of research progress and prospects.
    Ye Liu, Yi Li, Wei Shen, Min Li, Wen Wang, Xin Jin.
      Background: Delivery systems based on albumin nanoparticles (NPs) have recently garnered substantial interest in anti-tumor drug development. However, systematic bibliometric analyses in this field remain lacking. This study aimed to analyze the current research status, hotspots, and frontiers in the application of albumin NPs in the field of oncology from a bibliometric perspective.Methods: Using the Web of Science Core Collection (WOSCC) as the data source, retrieved articles were analyzed using software, such as VOSviewer 1.6.18 and CiteSpace 6.1.6, and the relevant visualization maps were plotted.
    Results: From 1 January 2000, to 15 April 2024, 2,262 institutions from 67 countries/regions published 1,624 articles related to the application of albumin NPs in the field of oncology. The USA was a leader in this field and held a formidable academic reputation. The most productive institution was the Chinese Academy of Sciences. The most productive author was Youn YS, whereas Kratz F was the most frequently co-cited author. The most productive journal was the International Journal of Nanomedicine, whereas the Journal of Controlled Release was the most co-cited journal. Future research hotspots and frontiers included "rapid and convenient synthesis methods predominated by self-assembly," "surface modification," "construction of multifunctional NPs for theranostics," "research on natural active ingredients mainly based on phenolic compounds," "combination therapy," and "clinical applications."
    Conclusion: Based on our bibliometric analysis and summary, we obtained an overview of the research on albumin NPs in the field of oncology, identified the most influential countries, institutions, authors, journals, and citations, and discussed the current research hotspots and frontiers in this field. Our study may serve as an important reference for future research in this field.
    Keywords:  albumin nanoparticles; anti-tumor; bibliometric research; clinical applications; hotspots
    DOI:  https://doi.org/10.3389/fphar.2024.1409163
  17. J Nepal Health Res Counc. 2024 Jun 21. 22(1): 1-11
    Indias Publications on Rheumatoid Arthritis: A Bibliometric Analysis of Research Output from 1994 to 2023 A.D.
    Raju Vaishya, Brij Mohan Gupta, Ghouse Modin Nabeesab Mamdapur, K S Ali, Abhishek Vaish.
      BACKGROUND: Over the years, several studies have been conducted by utilizing bibliometric techniques to reveal research trends in various sub-fields of medical sciences, including arthritis research. Although no bibliometric study has been conducted Methods:In this study, we examined the publications of Indian scholars on Rheumatoid Arthritis (RA) in the last three decades, using various quantitative and qualitative bibliometric indicators. The publications on RA (from 1994-2023) in the Scopus database were identified, analysed and evaluated using a pre-defined search strategy, and specialised software.RESULTS: 1603 papers were published on RA research that was cited 36814 times (averaging 11.48 citations per paper or CPP). The 18.65% and 16.71% of India's total publications indicated received external funding. The most productive Indian organizations were AIIMS (New Delhi), SGPGIMS (Lucknow) and PGIMER (Chandigarh). The most impactful organizations were AMU (Aligarh), Fortis Healthcare Ltd. (Gurgaon), and Punjab University (Chandigarh). The most productive authors were A. Aggarwal, R. Misra, A. Chopra, and U. Kumar. The most impactful authors were A. Aggarwal, A. Ghosh, S. Shankar, and R. Misra. Medicine (64.2% share), Pharmacology, Toxicology and Pharmaceutics (22.0% share), Biochemistry, Genetics and Molecular Biology (19.8% share) and Immunology and Microbiology (12.8% share) contributed the most publications in this area. Clinical studies (40.9% share), pathophysiology (13.2% share) and the treatment outcome (9.0% share) accounted maximally. The most significant keywords appearing in the area were: "Rheumatoid Arthritis", "Methotrexate", and "Rheumatoid Factor".
    CONCLUSIONS: This study provides insight into past, present, and future areas of India on research in RA and will help scholars identify the areas of collaboration.
    Keywords:  Bibliometric; highly cited papers; India; research; rheumatoid arthritis.
    DOI:  https://doi.org/10.33314/jnhrc.v22i01.5061
  18. F1000Res. 2023 ;12 1340
    Bibliometric analysis of scientific production on university social responsibility in Latin America and the Caribbean.
    Diego Urrunaga-Pastor, Guido Bendezu-Quispe, Deici Dávila-Altamirano, Milagritos N Asmat, Jordi Grau-Monge.
      Objective: To evaluate the scientific production on university social responsibility (USR) from institutions in Latin America and the Caribbean. Methods: A bibliometric analysis was conducted on documents published in indexed journals in the Scopus database from its inception until April 2023. Eligible documents included those on USR describing experiences carried out by universities in Latin America and the Caribbean. The number of articles per author, average authors per article, average citations per article, and the number of documents with one or more author were described. Bibliometric indicators regarding authors per article, co-authors per article, and institutional collaboration were presented. Bibliometric networks were constructed based on bibliographic coupling analysis of documents by countries and term co-occurrence in titles and abstracts. Results: Of a total of 4075 documents retrieved from Scopus, 150 were included. Documents published between 1997 and 2023 were identified, with an average annual growth rate of 2.7%. A total of 439 authors were identified, 18 articles had a single author, and an average of 0.3 articles per author and a co-authorship index of 3.13 were found. The percentage of international collaborations was 30.7%. Brazil had the highest proportion of publications (26.4%), followed by Chile (17%) and Colombia (13.2%). Opción and Revista de Ciencias Sociales were the journals with the highest number of articles published (13 each). In the analysis of term co-occurrence, recent years showed an increase in the use of terms related to e-learning, information and communication technologies, virtual education, COVID-19, sustainable development goals, and URSULA (initiative on USR in institutions in Latin America and the Caribbean). Conclusions: A growth in scientific production on USR in Latin America and the Caribbean was identified. The interest in USR documents in recent years has been focused on COVID-19 and the challenges of virtual education and sustainable development.
    Keywords:  Community; Higher education; Latin America; University; University social responsibility
    DOI:  https://doi.org/10.12688/f1000research.141987.2
  19. Front Neurol. 2024 ;15 1399600
    Research trends and hotspots for frontotemporal dementia from 2000 to 2022: a bibliometric analysis.
    Xinxin Chen, Yin Chen, Biyu Ni, Cheng Huang.
      Background: Frontotemporal dementia (FTD) is a neurodegenerative disease with clinical, pathological, and genetic heterogeneity. FTD is receiving increasing attention because it is the second leading cause of early-onset dementia after Alzheimer's disease. This study aimed to analyse the research trends and hotspots of FTD from 2000 to 2022 using bibliometrics.Methods: Papers related to FTD from 2000 to 2020 were systematically searched through the Web of Science Core Collection (WOSCC). Citespace and Vosviewer software were used to visually analyse the retrieved data of countries/regions, institutions, journals, authors, references, and keywords. Microsoft Excel was used to generate the annual publications and growth trends.
    Results: There were 10,227 papers included in the bibliometric analysis. The annual publication output on FTD has increased significantly from 2000 to 2022, with papers published in 934 academic journals and 87 countries/regions. The Journal of Alzheimer's Disease was the most popular, with 488 papers about FTD. The most productive countries/regions, institutions, and authors are the United States (n = 4,037), the University of California San Francisco (n = 687), and Miller, Bruce L. (n = 427), respectively. The article by Katya Rascovsky and her colleagues published on Brain in 2011 was the most cocited paper, with 625 citations. The research hotspots in this field were the clinical diagnostic criteria, subdivision, and pathological mechanism of FTD, such as tau protein, chromosome 17, progranulin, TDP-43, and C9orf72.
    Conclusion: The future research direction is based on biomarkers and pathological mechanisms to diagnose and differential diagnose FTD from the aspects of behavior, neuropathology, neuroimaging, and serum markers.
    Keywords:  Alzheimer’s disease; Citespace; Vosviewer; bibliometric analysis; frontotemporal dementia
    DOI:  https://doi.org/10.3389/fneur.2024.1399600
  20. Front Cardiovasc Med. 2024 ;11 1362551
    Research landscape of genetics in dilated cardiomyopathy: insight from a bibliometric analysis.
    Tiantian Chao, Yaru Ge, Jinghui Sun, Chenglong Wang.
      Background: Dilated cardiomyopathy (DCM) is a heterogeneous myocardial disorder with diverse genetic or acquired origins. Notable advances have been achieved in discovering and understanding the genetics of DCM. This study aimed to depict the distribution of the main research forces, hotspots, and frontiers in the genetics of DCM, thus shaping future research directions.Methods: Based on the documents published in the Web of Science Core Collection database from 2013 to 2022, co-authorship of authors, institutions, and countries/regions, co-citation of references, and co-occurrence of keywords were conducted respectively to present the distribution of the leading research forces, research hotspots, and emerging trends in the genetics of DCM.
    Results: 4,141 documents were included, and the annual publications have steadily increased. Seidman, Christine E, Meder, Benjamin, Sinagra, Gianfranco were the most productive authors, German Centre for Cardiovascular Research was the most productive institution, and the USA, China, and Germany were the most prolific countries. The co-occurrence of keywords has generated 8 clusters, including DCM, lamin a/c, heart failure, sudden cardiac death, hypertrophic cardiomyopathy, cardiac hypertrophy, arrhythmogenic cardiomyopathy, and next-generation sequencing. Frequent keywords with average publication time after 2019 mainly included arrhythmogenic cardiomyopathy, whole-exome sequencing, RBM 20, phenotype, risk stratification, precision medicine, genotype, and machine learning.
    Conclusion: The research landscape of genetics in DCM is continuously evolving. Deciphering the genetic profiles by next-generation sequencing and illustrating pathogenic mechanisms of gene variants, establishing innovative treatments for heart failure and improved risk stratification for SCD, uncovering the genetic overlaps between DCM and other inherited cardiomyopathies, as well as identifying genotype-phenotype correlations are the main research hotspots and frontiers in this field.
    Keywords:  bibliometric analysis; dilated cardiomyopathy; genetics; heart failure; sudden cardiac death
    DOI:  https://doi.org/10.3389/fcvm.2024.1362551
  21. World J Gastrointest Oncol. 2024 Jul 15. 16(7): 3321-3330
    Research trends and hotspots in the immune microenvironment related to hepatocellular carcinoma: A bibliometric and visualization study.
    Da-Ya Zhang, Fei-Hu Bai.
      BACKGROUND: The immune microenvironment (IME) in hepatocellular carcinoma (HCC) plays a pivotal role in determining patient outcomes and responses to treatment. This area is witnessing rapid growth in research interest. However, there is a lack of comprehensive bibliometric analyses that dissect trends and potential focal points in this field.AIM: To explore the evolution of research on the IME in HCC from January 1, 2004, to December 31, 2023, using bibliometric methodologies.
    METHODS: English articles and reviews concerning the IME of HCC were retrieved from the Web of Science Core Collection with a search date of December 31, 2023. The R package Bibliometrix was employed to compute basic bibliometric characteristics, illustrate collaborations among countries and authors, and create a three-field diagram illustrating the connections between authors, affiliations, and keywords. Analyses of country and institutional co-authorship, as well as keyword co-occurrence, were conducted using VOSviewer. Additionally, CiteSpace was utilized for the cite burst analysis of keywords and cited literature.
    RESULTS: The study encompassed 3125 documents in the research areas related to HCC of IME, revealing a substantial and continuous increase in the annual publication trend over time. China and Fudan University emerged as leading contributors, with 2103 and 165 publications, respectively. Frontiers in immunology was the most prolific journal in this domain. Among the top ten researchers in the field, eight are based in China. Key research terms identified include tumour microenvironment, expression, immunotherapy, and prognosis.
    CONCLUSION: The relationship between HCC and IME is receiving increasing attention, and related research is in a highly developed stage. Key focus areas, including IME and immune checkpoint inhibitors, immunotherapy are poised to be central to future research endeavors, offering promising pathways for further exploration.
    Keywords:  Bibliometrics; Citespace; Frontiers; Hepatocellular carcinoma; Immune microenvironment; VOSviewer
    DOI:  https://doi.org/10.4251/wjgo.v16.i7.3321
  22. Adv Exp Med Biol. 2024 Jul 30.
    Medication-Related Osteonecrosis of the Jaw: Bibliometric Analysis from 2003 to 2023.
    Ferit Bayram, Sabire Senem Kilic, Volkan Aydin, Ahmet Akici, Korkut Ulucan, Tunc Akkoc.
      Medication-related osteonecrosis of the jaw (MRONJ) is a serious condition associated with the use of antiresorptive and antiangiogenic medications. Despite extensive research, the pathophysiology of MRONJ remains poorly understood. Bibliometric analysis provides insights into the academic impact of research, helping identify influential works and emerging trends in this field. This study employed a bibliometric analysis of MRONJ publications indexed in Web of Science from 2003 to 2023. The analysis included English-language articles and utilized the VOSviewer, R Studio Bibliometrix package, and Graphpad to evaluate citation counts, publication trends, and collaboration patterns. This study unveils the current situation of the MRONJ research, addressing well-recognized safety issues of antiresorptive and antiangiogenic agents. Our findings may suggest that the overall trend of the MRONJ research continues to evolve and is not likely to reach its peak or plateau yet. We believe that our work will help to identify gaps in the literature and future research directions, contributing to a better understanding of MRONJ management.
    Keywords:  Antiangiogenic drugs; Antiresorptive drugs; Bibliometrics; MRONJ; Osteonecrosis of the jaw
    DOI:  https://doi.org/10.1007/5584_2024_818
  23. Front Cell Infect Microbiol. 2024 ;14 1355397
    Endophthalmitis: a bibliometric study and visualization analysis from 1993 to 2023.
    Xiangyu Fu, Wenyu Du, Ling Huang, Xiang Ren, Danian Chen.
      Aims: This study is designed to generalize and depict the research hotspots of endophthalmitis through bibliometric methods and software and analyze the evolutive tendency of the work on this severe disease over the past 30 years.Methods: This study employed a rigorous bibliometric approach. We identified all endophthalmitis-related literature by conducting a comprehensive search of the Science Citation Index Expanded database under the Web of Science Core Collection. The data was then analyzed and visualized using CiteSpace and VOSviewer, two widely recognized software tools in the field of bibliometrics. CiteSpace was used to analyze the country distributions, dual map overlay of journals, keyword bursts, and co-cited references. VOSviewer was employed to describe the authors and co-cited authors, the journals, the co-cited journals, and the keywords co-occurrence network. This robust methodology ensures the reliability and validity of the study's findings.
    Results: A total of 2960 publications, including 2695 articles and 265 reviews, were included in this bibliometric study. There has been no shortage of endophthalmitis-related publications since 1993, with an apparent upward trend during recent years. Possible correlations with the COVID-19 pandemic are also analyzed. These studies were finished by 11,048 authors from 75 countries worldwide, with the United States in the lead. In the keyword co-occurrence network, except for the endophthalmitis term, cataract surgery becomes the keyword with the highest frequency. Different categories of endophthalmitis, including postoperative, post-injection, post-traumatic, and endogenous endophthalmitis, and antibacterial and anti-inflammatory therapies of infectious endophthalmitis, are discussed by categories. From the perspective of the timeline, postoperative and post-injection endophthalmitis were the dominant forms before and after the year 2000, respectively. Co-citation analyses reveal that the Endophthalmitis Vitrectomy Study (EVS) conducted in 1995 provides pivotal guidance for later research. Diverse pathogenic bacteria (e.g., Coagulase-negative Staphylococci, Propionibacterium acnes, Viridians Streptococci, and Bacillus cereus) or fungi (e.g., Candida, Aspergillus, and Fusarium) contribute to varying treatment principles and clinical prognosis, which should be taken seriously. In addition, intravitreal and intracameral antibiotics are the mainstay for treating and preventing infectious endophthalmitis, respectively.
    Conclusion: Our bibliometric analysis provides an overview of dynamic evolution and structural relationships in the research field of endophthalmitis. The displayed hotspots and developmental directions have reference values for future investigation.
    Keywords:  Citespace; VOSviewer; bacterial; endogenous endophthalmitis; fungal; post-cataract endophthalmitis; post-injection; post-traumatic
    DOI:  https://doi.org/10.3389/fcimb.2024.1355397
  24. Rev Cardiovasc Med. 2022 Sep;23(9): 317
    Research Landscape on Atherosclerotic Cardiovascular Disease and Inflammation: A Bibliometric and Visualized Study.
    Wende Tian, Tai Zhang, Xinyi Wang, Jie Zhang, Jianqing Ju, Hao Xu.
      Background: The atherosclerotic cardiovascular disease (ASCVD) is a major killer and health care burden worldwide. Atherosclerosis, the common pathological foundation, has been associated with inflammation over the past few years. Some promising results also have emerged suggesting the role of targeting inflammation as a potential therapeutic option to reduce cardiovascular events. In light of the pathogenic role that inflammation plays in ASCVD, we propose to evaluate the worldwide research architecture for ASCVD and inflammation using bibliometric analysis.Methods: A search of the Web of Science Core Collection of Clarivate Analytics was performed for articles in the field published between 2012 and 2022. The number of publications per year has been visualized using GraphPad Prism through time. CiteSpace and VOSviewer were used to generate knowledge maps about the collaboration of countries, institutions, and authors, and to represent the landscape on ASCVD and inflammation research as well as to reveal current foci.
    Results: There were a total of 19,053 publications examined in this study. The most publications came from China (6232, 32.71%). Capital Med Univ was the most productive institution (410, 2.15%). Christian Weber published the greatest number of articles (75, 0.39%). PloS one was identified as the most prolific journal (706, 3.71%). Circulation was the most co-cited journal (13276, 2.81%). Keywords with the ongoing strong citation bursts were "nucleotide-binding oligomerization (NOD), Leucine-rich repeat (LRR)-containing protein (NLRP3) inflammasome", "intestinal microbiota", "exosome", "lncRNAs", etc.
    Conclusions: It can be shown that ASCVD and inflammation research benefited from manuscripts that had a high impact on the scientific community. Asian, European and North American countries dominated in the field in terms of quantitative, qualitative and collaborative parameters. The NLRP3 inflammasome, gut microbiota and trimethylamine N-oxide, autophagy, lncRNAs, exosomes, and nuclear factor erythroid 2-related factor 2 were described to be hot themes in the field.
    Keywords:  atherosclerotic cardiovascular disease; bibliometrics; hotspots; inflammation
    DOI:  https://doi.org/10.31083/j.rcm2309317
  25. Skin Res Technol. 2024 Aug;30(8): e13879
    Exploring the landscape of extracellular vesicle application for skin and plastic surgery: A bibliometric analysis from 2003 to 2023.
    Qian Liu, Hao Zhang, Yanan Zhu, Lingling Jia, Rong Guo, Yulin Sun, Juan Xu.
      BACKGROUND: Exosomes and other secretory membrane vesicles, collectively referred to as extracellular vesicles (EVs), have garnered increasing attention in research due to their biological characteristics. Notably, studies have shown promising results regarding the role of stem cell-derived extracellular vesicles (SC-EVs) in skin and plastic surgery applications. This study aims to elucidate current trends in SC-EVs within the context of skin and plastic surgery and offer insights for future research directions in advancing this critical field.METHODS: A comprehensive search was conducted for relevant studies on SC-EVs in skin and plastic surgery spanning from 2003 to 2023, utilizing the Web of Science database. Subsequently, data analysis was performed using VOSviewer and CiteSpace.
    RESULTS: A total of 1089 studies were identified, with a noticeable annual increase in publications on SC-EVs' application in skin and plastic surgery. China emerged as the leading contributor to this field, with Shanghai Jiao Tong University being a notable institution. Stem Cell Research & Therapy and the International Journal of Molecular Sciences were the top journals publishing relevant articles. Author Fu Xiaobing from the Chinese People's Liberation Army General Hospital had the highest publication count in this area. Keyword co-occurrence analysis revealed six distinct clusters, with "exosomes" being the most prevalent keyword in recent years. Wound healing and skin rejuvenation emerged as primary research focuses and hotspots in this field.
    CONCLUSION: This comprehensive review offers insights into global trends surrounding SC-EVs in skin and plastic surgery. Analysis of journals, institutions, references, and keywords provides valuable guidance for researchers in determining future research directions.
    Keywords:  bibliometric analysis; exosomes; extracellular vesicles; skin and plastic surgery; stem cells
    DOI:  https://doi.org/10.1111/srt.13879
  26. Front Pharmacol. 2024 ;15 1390483
    Global research trends on gut microbiota and metabolic dysfunction-associated steatohepatitis: Insights from bibliometric and scientometric analysis.
    Naqash Alam, Linying Jia, Ao Cheng, Honghao Ren, Yu Fu, Xinhua Ding, Ihtisham Ul Haq, Enqi Liu.
      Background: Metabolic dysfunction-associated steatohepatitis (MASH) is an inflammatory subtype of metabolic dysfunction-associated steatotic liver disease (MASLD) has recently been proposed as a replacement term for NAFLD, a common, multifactorial and poorly understood liver disease whose incidence is increasing worldwide. In recent years, there has been increasing scientific interest in exploring the relationship between gut microbiota and MASH. To learn more about the gut microbiota in MASH, this study aims to provide a comprehensive analysis of the knowledge structure and research hotspots from a bibliometric perspective.Methods: We searched the Web of Science Core Collection for articles and reviews that covered the connections between gut microbiota and MASH over the last decade. The Online Analysis Platforms, VOSviewer, CiteSpace, the R tool "bibliometrix" were used to analyzed existing publications trends and hotspots.
    Results: A total of 4,069 documents related to the interaction between gut microbiota and MASH were retrieved from 2014 to 2023. The number of annual publications increased significantly over the last decade, particularly in the United States and China. The University of California-San Diego was the most productive institution, while researcher Rohit Loomba published the most papers in the field. Younossi ZM was ranked as the first co-cited author and largest contributor of highly cited articles in the field. Gastroenterology and hepatology were the most common specialty category. The most cited journal in the last decade was Hepatology. The Keyword Bursts analysis highlighted the importance of studying the association between gut microbiota and MASH, as well as related factors such as metabolic syndrome, insulin resistance, endotoxemia and overgrowth of gut bacteria. Keyword clusters with co-citation were used to illustrate important topics including intestinal permeability, insulin sensitivity and liver immunology. The most common keywords include insulin resistance, obesity, dysbiosis, inflammation and oxidative stress, which are current hotspots.
    Conclusion: Our analysis highlights key aspects of this field and emphasizes multiorgan crosstalk in MASLD/MASH pathogenesis. In particular, the central role of the gut-liver axis and the significant influence of gut microbiota dysbiosis on disease progression are highlighted. Furthermore, our results highlight the transformative potential of microbiota-specific therapies and cover the way for innovative healthcare and pharmaceutical strategies.
    Keywords:  Citespace; NASH; VOSviewer; bibliometrix; gut microbiota; visualization
    DOI:  https://doi.org/10.3389/fphar.2024.1390483
  27. Front Pharmacol. 2024 ;15 1392241
    Metabolic reprogramming in hepatocellular carcinoma: a bibliometric and visualized study from 2011 to 2023.
    Xia Li, Liping Zhou, Xinyi Xu, Xiyang Liu, Wenjun Wu, Quansheng Feng, Ziwei Tang.
      Background and aims: Metabolic reprogramming has been found to be a typical feature of tumors. Hepatocellular carcinoma (HCC), a cancer with high morbidity and mortality, has been extensively studied for its metabolic reprogramming-related mechanisms. Our study aims to identify the hotspots and frontiers of metabolic reprogramming research in HCC and to provide guidance for future scientific research and decision-making in HCC metabolism.Methods: Relevant studies on the metabolic reprogramming of HCC were derived from the Web of Science Core Collection (WoSCC) database up until November 2023. The bibliometrix tools in R were used for scientometric analysis and visualization.
    Results: From 2011 to 2023, a total of 575 publications were obtained from WoSCC that met the established criteria. These publications involved 3,904 researchers and 948 organizations in 37 countries, with an average annual growth rate of 39.11% in research. These studies were published in 233 journals, with Cancers (n = 29) ranking first, followed by Frontiers in Oncology (n = 20) and International Journal of Molecular Sciences (n = 19). The top ten journals accounted for 26% of the 575 studies. The most prolific authors were Wang J (n = 14), Li Y (n = 12), and Liu J (n = 12). The country with the most publications is China, followed by the United States, Italy, and France. Fudan University had the largest percentage of research results with 15.48% (n = 89). Ally A's paper in Cell has the most citations. A total of 1,204 keywords were analyzed, with the trend themes such as "glycolysis," "tumor microenvironment," "Warburg effect," "mitochondria," "hypoxia ," etc. Co-occurrence network and cluster analysis revealed the relationships between keywords, authors, publications, and journals. Moreover, the close collaboration between countries in this field was elucidated.
    Conclusion: This bibliometric and visual analysis delves into studies related to metabolic reprogramming in HCC between 2012 and 2023, elucidating the characteristics of research in this field, which has gradually moved away from single glycolipid metabolism studies to the integration of overall metabolism in the body, pointing out the trend of research topics, and the dynamics of the interaction between the tumor microenvironment and metabolic reprogramming will be the future direction of research, which provides blueprints and inspirations for HCC prevention and treatment programs to the researchers in this field.
    Systematic Review Registration: [https://www.bibliometrix.org].
    Keywords:  Warburg effect; bibliometric; hepatocellular carcinoma; metabolic reprogramming; tumor microenvironment
    DOI:  https://doi.org/10.3389/fphar.2024.1392241
  28. Asian J Surg. 2024 Jul 30. pii: S1015-9584(24)01579-3. [Epub ahead of print]
    Knowledge mapping of hyperbaric oxygen therapy in sudden sensorineural hearing loss: A bibliometric analysis (2015-2024).
    Shuo Wang, Guanyi He.
      
    DOI:  https://doi.org/10.1016/j.asjsur.2024.07.206
  29. Osong Public Health Res Perspect. 2024 Aug 02.
    Infectious disease research in the Association of Southeast Asian Nations region: a scientometric analysis.
    Joseph Christian Obnial, Catherine Joy Escuadra, Adriana Viola Miranda, Don Eliseo Eliseo Lucero-Prisno Iii.
      Objectives: This study compared the research output of Association of Southeast Asian Nations (ASEAN) countries to understand research trends and clarify past, present, and future patterns using scientometric techniques.Methods: This scientometric study systematically mined health and social science publications from the Web of Science and Scopus databases using keywords associated with infectious disease. The analysis included only English-language articles and review articles by authors from any ASEAN country. Publication, citation, and text co-occurrence network analyses were performed. R Studio and VOSviewer enabled data management, analysis, and visualization.
    Results: Searches identified 12,511 articles published between 1925 and 2022, with a notable increase in research publications since 2003. The leading journals on infectious disease were associated with established publishing houses, including BMC, BMJ, and The Lancet. The most-cited articles were primarily global burden of disease studies, with 7,367 citations. Among ASEAN countries, Thailand, Malaysia, and Singapore had the most publications and collaborative efforts on the topic. Analysis of keyword co-occurrence revealed clusters related to global health, dengue, bacterial studies, non-dengue viral topics, and diagnostics. Most early studies examined diagnostics, gene and sequencing methodologies, and virology; later, the focus shifted toward herbal and alternative medicine.
    Conclusion: Recently, the research capacity of Southeast Asia has expanded dramatically, with substantial contributions from high-income countries (HICs). Intense cooperation between member states is essential, emphasizing the role of HICs in supporting their neighbors. Increased research efforts must be dedicated to innovative approaches to combat persistent health conditions, along with emerging issues like climate change.
    Keywords:  Association of Southeast Asian Nations; Infectious disease; Scientometric analysis; Southeast Asia
    DOI:  https://doi.org/10.24171/j.phrp.2024.0058
  30. Cureus. 2024 Jun;16(6): e63337
    Bibliometric Analysis and Visualization of Scientific Literature on Heart Disease Classification Using a Logistic Regression Model.
    Neena Suresh, Binu Thomas, Jeena Joseph.
      With the advancement in artificial intelligence, the use of machine learning algorithms for clinical prediction has increased tremendously. Logistic regression is one of the powerful machine learning algorithms that can be used to predict the probability of a variable. Logistic regression is very popular among medical researchers owing to its simplicity, interpretability, and solid statistical foundation. This study aims to investigate the research productivity of heart disease classification using a logistic regression model to analyze the current patterns and potential future trends through bibliometric analysis. Additionally, it aims to highlight the impact and quality of research in the area, identify prominent research groups, the countries actively contributing to the field, which will help the researchers and healthcare professionals to pinpoint research gaps, influential authors, and make informed decisions and invest resources accordingly. The data is collected from a database of Scopus spanning from 2019 to 2023. We have used two bibliometric software, Biblioshiny (Aria and Cuccurullo, 2017) and VOSviewer (Centre for Science and Technology Studies (CWTS), Leiden University, the Netherlands), to analyze the bibliographic data regarding the citation count, contribution of authors, publication count, the contribution of institutions, etc. There are 2331 documents under study which were fed into both software to analyze the data. With 700 documents, China topped the list of most productive countries indicating the vast contribution of the country followed by India and the United States. Contributions of the Harvard Medical School, Boston, MA, United States are found to be the greatest with six papers. The most productive author is Wang Y with 73 documents. Analysis of trending topics reveals that the field progressing towards using support vector machines (SVM), k-nearest neighbours (KNN), and naïve Bayes algorithms. The article has only considered data from Scopus excluding literature indexed in other databases which limits the potential coverage of the data. Also, the work focuses on recent developments excluding older literature from 2019 which could be a limitation. Furthermore, since the study is a bibliometric analysis targeting the use of logistic regression for heart disease prediction, powerful techniques such as SVM, decision trees, random forests, neural networks and deep learning have not been included, which could be another limitation.
    Keywords:  bibliometric analysis; biblioshiny; cardiovascular diseases; logistic regression; machine learning; vosviewer
    DOI:  https://doi.org/10.7759/cureus.63337
  31. J Am Dent Assoc. 2024 Jul 31. pii: S0002-8177(24)00312-X. [Epub ahead of print]
    Artificial intelligence applications in dentistry: A bibliometric review with an emphasis on computational research trends within the field.
    Fernanda Pretto Zatt, Aurélio de Oliveira Rocha, Lucas Menezes Dos Anjos, Ricardo Armini Caldas, Mariane Cardoso, Gustavo Davi Rabelo.
      BACKGROUND: The aim of this study was to understand the trends regarding the use of artificial intelligence in dentistry through a bibliometric review.TYPES OF STUDIES REVIEWED: The authors performed a literature search on Web of Science. They collected the following data: articles-number and density of citations, year, key words, language, document type, study design, and theme (main objective, diagnostic method, and specialties); journals-impact factor; authors-country, continent, and institution. The authors used Visualization of Similarities Viewer software (Leiden University) to analyze the data and Spearman test for correlation analysis.
    RESULTS: After selection, 1,478 articles were included. The number of citations ranged from 0 through 327. The articles were published from 1984 through 2024. Most articles were characterized as proof of concept (979). Definition and classification of structures and diseases was the most common theme (550 articles). There was an emphasis on radiology (333 articles) and radiographic-based diagnostic methods (715 articles). China was the country with the most articles (251), and Asia was the continent with the most articles (871). The Charité-University of Medicine Berlin was the institution with the most articles (42), and the author with the most articles was Schwendicke (53).
    PRACTICAL IMPLICATIONS: Artificial intelligence is an important clinical tool to facilitate diagnosis and provide automation in various processes.
    Keywords:  Deep learning; bibliometrics; dentistry; machine learning
    DOI:  https://doi.org/10.1016/j.adaj.2024.05.013
  32. Curr Neuropharmacol. 2024 Jul 31.
    Bibliometric Analysis of Alzheimer's Disease and Depression.
    Sixin Li, Qian Zhang, Jian Liu, Nan Zhang, Xinyu Li, Ying Liu, Huiwen Qiu, Jing Li, Hui Cao.
      BACKGROUND: The link between Alzheimer's disease and depression has been confirmed by clinical and epidemiological research. Therefore, our study examined the literary landscape and prevalent themes in depression-related research works on Alzheimer's disease through bibliometric analysis.METHODS: Relevant literature was identified from the Web of Science core collection. Bibliometric parameters were extracted, and the major contributors were defined in terms of countries, institutions, authors, and articles using Microsoft Excel 2019 and VOSviewer. VOSviewer and CiteSpace were employed to visualize the scientific networks and seminal topics.
    RESULTS: The analysis of literature utilised 10,553 articles published from 1991 until 2023. The three countries or regions with the most publications were spread across the United States, China, and England. The University of Toronto and the University of Pittsburgh were the major contributors to the institutions. Lyketsos, Constantine G., Cummings, JL were found to make outstanding contributions. Journal of Alzheimer's Disease was identified as the most productive journal. Furthermore, "Alzheimer's", "depression", "dementia", and "mild cognitive decline" were the main topics of discussion during this period.
    LIMITATIONS: Data were searched from a single database to become compatible with VOSviewer and CiteSpace, leading to a selection bias. Manuscripts in English were considered, leading to a language bias.
    CONCLUSION: Articles on "Alzheimer's" and "depression" displayed an upward trend. The prevalent themes addressed were the mechanisms of depression-associated Alzheimer's disease, the identification of depression and cognitive decline in the early stages of Alzheimer's, alleviating depression and improving life quality in Alzheimer's patients and their caregivers, and diagnosing and treating neuropsychiatric symptoms in Alzheimer. Future research on these hot topics would promote understanding in this field.
    Keywords:  Alzheimer’s; CiteSpace; VOSviewer.; bibliometric analysis; depression; hotspots
    DOI:  https://doi.org/10.2174/1570159X22666240730154834
  33. Am J Geriatr Psychiatry. 2024 Jul 04. pii: S1064-7481(24)00382-8. [Epub ahead of print]
    Explanatory Note - CiteScore Versus Impact Factor.
    Joshua R Spieler.
      
    DOI:  https://doi.org/10.1016/j.jagp.2024.07.001
  34. Medicine (Baltimore). 2024 Aug 02. 103(31): e39182
    Global research on emerging trends of obstetrics during the COVID-19 pandemic: A bibliometric analysis.
    Qin-Yu Cai, Yun-Ren Pan, Bei-Ning Deng, Wen-Dong Hu, Zong-Yan He, Xu Zhang, Wei-Zhen Tang, Tai-Hang Liu, Xia Lan.
      Coronavirus disease-2019 (COVID-19) has caused continuous effects on the global public, especially for susceptible and vulnerable populations like pregnant women. COVID-19-related studies and publications have shown blowout development, making it challenging to identify development trends and hot areas by using traditional review methods for such massive data. Aimed to perform a bibliometric analysis to explore the status and hotspots of COVID-19 in obstetrics. An online search was conducted in the Web of Science Core Collection (WOSCC) database from January 01, 2020 to November 31, 2022, using the following search expression: (((TS= ("COVID 19" OR "coronavirus 2019" OR "coronavirus disease 2019" OR "SARS-CoV-2" OR "2019-nCoV" OR "2019 novel coronavirus" OR "SARS coronavirus 2" OR "Severe Acute Respiratory Syndrome Coronavirus-2" OR "SARS-COV2")) AND TS= ("obstetric*" OR "pregnancy*" OR "pregnant" OR "parturition*" OR "puerperium"))). VOSviewer version 1.6.18, CiteSpace version 6.1.R6, R version 4.2.0, and Rstudio were used for the bibliometric and visualization analyses. 4144 articles were included in further analysis, including authors, titles, number of citations, countries, and author affiliations. The United States has contributed the most significant publications with the leading position. "Sahin, Dilek" has the largest output, and "Khalil, Asma" was the most influential author with the highest citations. Keywords of "Cov," "Experience," and "Neonate" with the highest frequency, and "Systematic Review" might be the new research hotspots and frontiers. The top 3 concerned genes included ACE2, CRP, and IL6. The new research hotspot is gradually shifting from the COVID-19 mechanism and its related clinical research to reviewing treatment options for pregnant women. This research uniquely delves into specific genes related to COVID-19's effects on obstetrics, a focus that has not been previously explored in other reviews. Our research enables clinicians and researchers to summarize the overall point of view of the existing literature and obtain more accurate conclusions.
    DOI:  https://doi.org/10.1097/MD.0000000000039182
  35. Integr Zool. 2024 Jul 29.
    The changes in zoological publication rates and focal subdisciplines between 1960 and 2022.
    Tianbao Luo, Liyu Li, Qian Wang, Wentong Liu, Jinyu Guo, Yimei Yan, Newman Chris, Youbing Zhou, Jin Zhao.
      Since ancient times, zoology, as the branch of biology dealing with animals, has been a cornerstone of natural science and has developed substantially over the last century. We conducted a bibliometric analysis using structural topic modeling (STM) to determine changes in the representation of principal zoological subdisciplines in the literature between 1960 and 2022. We collated a corpus of 217 414 articles from 88 top-ranked zoology journals and identified three main fields: (i) ecology, (ii) evolution, and (iii) applied research. Within these, we identified 10 major subdisciplines. The number of studies published per year grew from 118 in 1960 to 6635 in 2022. Macroscale-related subdisciplines increased while classical and traditional subdisciplines decreased. Mammals (34.4%) and insects (18.1%) were the dominant taxa covered, followed by birds (15.2%) and fish (8.0%). Research on mammals, insects, and fish involved a broad range of subdisciplines, whereas studies of birds focused on ecological subdisciplines. Most publications were from the United States, followed by the United Kingdom, Germany, Canada, Australia, China, and Japan, with two developing countries, China and South Africa among the top 15 countries. There were different subdiscipline biases between countries, and the gross domestic product of each country correlated positively with its publication output (R2 = 0.681). We discuss our findings in the context of advances in technological innovations and computing power, as well as the emergence of ecology as a formal sister discipline, driven by changing environmental pressures and societal values. We caution that valuable publications from traditional zoological fields must not be completely supplanted by more contemporary topics and increasingly sophisticated analyses.
    Keywords:  bibliometric analysis; collaboration; publication rates; structural topic modeling; zoology
    DOI:  https://doi.org/10.1111/1749-4877.12883
  36. Front Pharmacol. 2024 ;15 1388641
    Mapping the global research landscape on depression for patients with chronic kidney disease: a bibliometric and visualized analysis from 2006 to 2022.
    Wenchao Xu, Zitong Chen, Yurong Zhang, Jiayu Zhao, Wenyong Huang, Xiao Guo, Jianyu Zhang.
      Background: Chronic Kidney Disease (CKD), a complex and multifaceted health issue, significantly contributes to global mortality rates. Accompanying chronic conditions, depression notably exacerbates health outcomes, increasing both mortality risk and the burden on affected individuals. This study employs bibliometric and visual analytics to evaluate the evolution, current trends, and future research directions in the field of CKD and depression.Methods: We conducted a thorough investigation using the Web of Science Core Collection, focusing on literature published from 2006 to 2022 that examines the interplay between CKD and depression. The analysis was enriched with bibliometric and visualization tools such as bibliometrix, CiteSpace, and VOSviewer to distill the essence of the research corpus.
    Results: Our analysis incorporated 2,409 CKD-related publications, with significant contributions from the United States, China, and England. BMC Nephrology emerged as the leading publication outlet, while the American Journal of Kidney Diseases featured the most cited articles. Key terms such as "depression," "quality-of-life," "mortality," "prevalence," and "hemodialysis" dominated the keyword landscape, indicating the research focus areas.
    Conclusion: This bibliometric analysis offers an in-depth view of the research trajectory in CKD and depression. It provides valuable insights for researchers seeking relevant literature, potential collaborators, and an understanding of the field's current hotspots and emerging frontiers. The findings of this study are instrumental in guiding and enriching future research endeavors in this domain.
    Keywords:  CKD; VOSviewer; bibliometrix; chronic kidney disease; depression
    DOI:  https://doi.org/10.3389/fphar.2024.1388641
  37. J Environ Manage. 2024 Jul 26. pii: S0301-4797(24)01928-5. [Epub ahead of print]367 121942
    An in-depth analysis of membrane distillation research (1990-2023): Exploring trends and future directions through bibliometric approach.
    Ali Boubakri, Sarra Elgharbi, Salah Bouguecha, Jamel Orfi, Mabrouka El Oudi, Olfa Bechambi, Amor Hafiane.
      This bibliometric analysis offers a comprehensive investigation into membrane distillation (MD) research from 1990 to 2023. Covering 4389 publications, the analysis sheds light on the evolution, trends, and future directions of the field. It delves into authorship patterns, publication trends, prominent journals, and global contributions to reveal collaborative networks, research hotspots, and emerging themes within MD research. The findings demonstrate extensive global participation, with esteemed journals such as Desalination and the Journal of Membrane Science serving as key platforms for disseminating cutting-edge research. The analysis further identifies crucial themes and concepts driving MD research, ranging from membrane properties to strategies for mitigating membrane fouling. Co-occurrence analysis further highlights the interconnectedness of research themes, showcasing advancements in materials, sustainable heating strategies, contaminant treatment, and resource management. Overlay co-occurrence analysis provides temporal perspective on emerging research trends, delineating six key topics that will likely shape the future of MD. These include innovations in materials and surface engineering, sustainable heating strategies, emerging contaminants treatment, sustainable water management, data-driven approaches, and sustainability assessments. Finally, the study serves as a roadmap for researchers and engineers navigating the dynamic landscape of MD research, offering insights into current trends and future trajectories, ultimately aiming to propel MD technology towards enhanced performance, sustainability, and global relevance.
    Keywords:  Bibliometric analysis; Future directions; Membrane distillation; Research hotspots; Sustainability; Water scarcity
    DOI:  https://doi.org/10.1016/j.jenvman.2024.121942
  38. Int Heart J. 2024 ;65(4): 786
    Most Cited Articles in 2023.
      
    DOI:  https://doi.org/10.1536/ihj.65-4_Mostcited
  39. World J Clin Cases. 2024 Jul 26. 12(21): 4717-4725
    Visual analysis of abdominal aortitis treatment using the CiteSpace bibliometric method.
    Si-En Guo, Yuan-Biao Meng, Zan-Man Zhang, Yu-Lan Zhang, Qi-Sen Yao, Xiao Qin.
      BACKGROUND: Abdominal aortitis can induce aneurysms, and tumor rupture can lead to organ ischemia or even sudden death. At present, there is a lack of extensive understanding and identification of key problems in the treatment of abdominal aortitis, which needs to be further analyzed using bibliometric analysis.AIM: To discuss the research hotspot and development trend of abdominal aortitis treatment.
    METHODS: We searched the English literature (published from January 1, 2000 to March 12, 2024) on the treatment of abdominal aortitis in the Web of Science database. Then, we identified and screened duplicate literature using CiteSpace 6.1R2 software. We conducted an analysis of the number of papers, a co-occurrence analysis of the authors and institutions, and co-occurrence and cluster analyses of the keywords. Then, we drew the author, institution, and keywords of the studies into graphs for visualization. Finally, we expounded on the author, institutional network interactions, and hot keywords of the studies on the treatment of abdominal aortitis.
    RESULTS: We included 210 English literature articles involving 190 authors; the author cooperation team was mainly represented by Caradu Caroline, Berard Xavier, Lu Guanyi, Harada Kenichi, and Sharma Ashish K. In the keyword analysis, high-frequency keywords include abdominal aortic aneurysm (38), abdominal aorta (24), Takayasu arteritis (22), etc. The three most central keywords were disease (0.69), classification (0.68), and abdominal aortic aneurysm (0.55). The first nine clusters of keywords are case report, abdominal aortic aneurysm, Takayasu arteritis, dyspnea hematuria, aortic elastic, IgG4-related disease, report, mid aortic dysplastic syndrome, and statin. In the keyword emergent analysis, 14 emergent words were obtained. Among them, seven keywords with strong abruptness were Takayasu arteritis, abdominal aortic aneurysm, disease, retroperitoneal fibrosis, expression, management, and large vessel vasculitis. In the past 3 years, the incidences of abdominal aortic aneurysm (intensity: 4.62) and inflammation (intensity: 1.99) were higher.
    CONCLUSION: The number of published papers is on the increase, but the cooperation among authors is scattered. The research focus is mainly on the pathogenesis and treatment of abdominal aortitis-related diseases.
    Keywords:  Abdominal aortic aneurysm; Abdominal aortitis; CiteSpace; Cluster; Treatment; Visualization
    DOI:  https://doi.org/10.12998/wjcc.v12.i21.4717
  40. Sci One Health. 2022 Nov;1 100012
    A One Health information database based on standard bibliometric analysis.
    Ne Qiang, Si-Yu Gu, Xin-Yi Wang, Xiao-Xi Zhang, Shang Xia, Jin-Xin Zheng, Wen-Feng Gong, Robert Bergquist, Jin-Jun Ran, Le-Fei Han.
      Background: One Health is an integrated concept of health that aims to optimize the health of humans, animals, plants, and the environment. Identifying research gaps and specific expertise areas is important for understanding the role of One Health in practice. This information on One Health could be used to promote collaboration and research, inspire innovative ideas, and accelerate the translation of evidence-based practices into policies.Methods: We searched the Scopus database for publications related to One Health between 2012 and 2021 to extract bibliometric information and investigate the possibility of establishing a dedicated expertise database. We matched scholarly information using SciVal to exclude duplicate information and identify scholars' affiliations, countries, and academic profiles. Individual academic contributions to One Health were evaluated according to their citations, publication impact, publication type, and author contributions.
    Results: A total of 8,313 publications on One Health over a ten-year period were identified, with the number of publications increasing over time. The largest number of publications came from the United States and the United Kingdom. These countries also had the highest number of experts and a high level of international collaboration. We identified 500 scholars from 53 countries and 313 affiliations with a median Hirsch Index of 20 who could be included in a One Health expert database. These scientists had a median of six publications on One Health, with topics mostly focusing on dengue and antimicrobial resistance.
    Conclusion: A One Health information database could be used as a third-party reference for scholars, a source to track the ongoing academic progress, and support for active scholars in this field of research.
    Keywords:  Bibliometric analysis; Database; Experts; One Health
    DOI:  https://doi.org/10.1016/j.soh.2023.100012
  41. Sci One Health. 2024 ;3 100052
    Unveiling the global reach of African anthrax research: A bibliometric study.
    Ishaku Leo Elisha, Arieri Onikisateinba, Ganih Saidu Joel, Pam Dachung Luka, Barde Israel Joshua, Shuaibu Hafsat Jagab, Rabi Ahmed, Habibu Haliru, Sa'adatu Aliyu Abubakar, Sunday Makama, Ngulukun Samuel Sati, Maryam Muhammad.
      Anthrax is a zoonotic bacterial disease caused by Bacillus anthracis. It poses significant threat to humans through contact with infected animals or their by-products. Concerns arise from its long-lasting spore viability and lethality, fuelling its biowarfare potential. Recent anthrax outbreaks across multiple African nations prompted this bibliometric study. The aim of the study was to assess the contributions of African countries, institutions, authors, research funding, and collaborations, while identifying research trends and gaps. We conducted an extensive bibliometric analysis of anthrax-related research publications in Africa from 1923 to 2023, utilizing the Scopus database and VOSviewer. The study covered 364 publications from 32 African countries, accumulating 5,636 citations at an average of 15.5 citations per article, with research articles comprising 88.5% of the corpus. The publication growth rate from 1923 to 2023 was modest at 8.3%, indicating gradual advancement. Notably, there was a significant surge in publications between 2011 and 2023, accounting for 73.1% of total publications. The African research contributions, were categorized into five thematic focuses: ecological dynamics and host interactions, human-livestock anthrax interface, molecular insights into bacterial activity and treatment strategies, collaborative approaches for zoonotic disease prevention, and antibody response and vaccination strategies. Leading institutional contributors included the University of Pretoria and the University of KwaZulu-Natal. Collaborations extended globally to 35 non-African countries, with significant involvement from the United States, United Kingdom, and Germany. Strong African partnerships, especially between Kenya, Nigeria, and South Africa, emerged. The top 10 cited papers explored diverse aspects, including disease impact on wildlife and innovative control strategies, underscoring the importance of multidisciplinary approaches. South Africa played a prominent role, contributing 95 publications and securing funding from various sources, including the National Research Foundation. Collaborations with global institutions highlighted its commitment. This study unveils the dynamic landscape of anthrax research in Africa, emphasizing the pivotal role of collaboration, multidisciplinary One Health approaches, and global partnerships in enhancing research outcomes. Ongoing research and practical solutions for human and animal health remain imperative.
    Keywords:  Africa; Anthrax; Bibliometrics; Collaborations; Global impacts; Outbreaks
    DOI:  https://doi.org/10.1016/j.soh.2023.100052
  42. Eur J Radiol. 2024 Jul 18. pii: S0720-048X(24)00344-9. [Epub ahead of print]178 111628
    Assessing sex and gender equity in submission guidelines of radiology journals: A cross-sectional study.
    Faisal Khosa, Matthew Stewart, Lulu Liu, Jeffrey Ding, Oleya Rahmim, Ahmad Abu-Omar.
      PURPOSE: Our study aimed to determine the current percentage of gender and sex equity promoting (GSEP) radiology journals, defined as satisfying at least one criterion of the Sex and Gender Equity in Research (SAGER) checklist, published by the European Association of Science Editors (EASE). A secondary objective was to compare characteristics of GSEP and non-GSEP journals.METHODS: A cross-sectional analysis between June 24 and July 3, 2023, was conducted. The author submission guidelines of radiology journals with a 2021 Journal Impact Factor (JIF) were assessed according to the SAGER checklist. GSEP journals were defined as satisfying one or more SAGER checklist criteria in their research instructions. Bibliometric data and journal information were collected from the Journal Citation Reports and National Library of Medicine catalogue.
    RESULTS: Only 39.7 % (52) of 132 journals satisfied at least one SAGER checklist criterion. Median 2021 JIFs were higher in GSEP journals (4.62, IQR: 3.73 - 5.21) than non-GSEP journals (2.70, IQR: 2.32) (p = 0.00). Median 2021 Journal Citation Index (JCI) scores were higher in GSEP (0.64, 0.56 - 0.73) than non-GSEP journals (0.97, 0.83 - 1.10) (p = 0.00). Cited half-life was shorter for GSEP (5.40, 4.80 - 6.50) than non-GSEP journals (6.70, 5.70 - 7.40) (p = 0.05). Elsevier published 33 of 52 of GSEP journals.
    CONCLUSION: 60.3% of radiology journals with a 2021 JIF do not meet a single SAGER checklist criterion in their author submission guidelines. GSEP journals had higher impact and source metrics and a shorter cited half-life. Publishers may play a significant role in promoting endorsement of the SAGER checklist in the author submission guidelines of radiology journals.
    Keywords:  Affirmative action; Gender inclusivity; Impact factor; Radiology; Research practice; SAGER guidelines
    DOI:  https://doi.org/10.1016/j.ejrad.2024.111628
  43. J Palliat Med. 2024 Aug 02.
    Spiritual Care in Palliative Medicine and End of Life: A Bibliometric Network Analysis.
    Jacopo D'Andria Ursoleo, Cristiano Calì, Rosario Losiggio, Vito Limone, Elena Mucci, Fabrizio Monaco.
      Background and Objectives: Spiritual care is an essential component of care for the terminally ill, because of its potential to positively impact patient perception of quality of life and dignity. However, it continues to be the least cultivated or even most overlooked aspect of palliative care and end of life. We performed a methodological review using bibliometric analysis to provide a holistic view of the scientific output published on this topic in the literature at the same time outlining present perspectives and research trends. Methods: In accordance with the BIBLIO checklist for reporting the bibliometric reviews of the biomedical literature, pertinent articles were retrieved from the Web of Science (WOS) database. The search string included "spiritual care," "end of life," and their synonyms. The VOSviewer (version 1.6.17) software was used to conduct comprehensive analyses. Semantic and research networks, bibliographic coupling, and journal analysis were examined. Results: A total of 924 articles were identified in WOS, and 842 were retrieved. An increasing trend in the number of publications is observed from 1981 to date, with a peak in the 2019-2021 timeframe. Most articles focused on palliative care, spirituality, spiritual care, religion, end of life, and cancer. The Journal of Pain and Symptom Management contributed the highest number of published documents, while the Journal of Palliative Medicine was the top-cited journal. The highest number of publications originated from collaborations of authors from the United Kingdom, the United States, and Australia. Conclusion: The remarkable increase in the number of publications on spiritual care observed in the years of the COVID-19 pandemic likely reflected global concerns, reasserting the importance of prioritizing spiritual care for whole-person palliation. Spiritual care is integrated with palliative care, in line with the latter's holistic nature and the recognition of spirituality as a fundamental aspect of end-of-life care. Nurses and chaplains exhibited more involvement in palliative-spiritual care than physicians reflecting the belief that chaplains are perceived as specialized providers, and nurses, owing to their direct exposure to spiritual suffering and ethos, are deemed suitable for providing spiritual care.
    Keywords:  bibliometric network analysis; end of life; end-of-life care; palliative care; spiritual care; spirituality
    DOI:  https://doi.org/10.1089/jpm.2024.0007
  44. Medicine (Baltimore). 2024 Aug 02. 103(31): e38903
    Prominent themes in shoulder dystocia research: A bibliometric and document-based analysis.
    Ayse Konac, Fatih Orhan.
      BACKGROUND: This study aims to comprehensively examine the academic development of shoulder dystocia (SD) through bibliometric and document analysis and to identify topics that can guide future research.METHODS: In this study, performance, co-citation, co-word, and document analyses were used as bibliometric analysis techniques.
    RESULTS: The study identified 3 main themes in terms of the intellectual structure of Shoulder Dystocia (SD): "Management of SD, Risk Factors and Associated Complications," "Clinical Practices, Birth Abnormalities and Effects of Complications," and "Impact of Education, Clinical Maneuvers and Fetal Health Outcomes." Co-occurrence analysis identified 4 significant themes: "Management and Clinical Practice of SD," "Fetal Macrosomia and Risk Factors," "Obstetric Maneuvers and Brachial Plexus Injury," and "Clinical Trends and Risks in SD." Additionally, ten consolidated themes were identified as a result of thematic coding analysis.
    CONCLUSION: Shoulder dystocia remains a critical component of obstetric practice. Themes such as training and simulation, risk factors, and technical and management approaches are consistently emphasized. Technological advances and studies on how machine learning techniques can be used effectively in this field reflect innovative approaches in the scientific literature. This analysis confirms that shoulder dystocia is a complex topic requiring a multidisciplinary approach and that research in this field is constantly evolving.
    DOI:  https://doi.org/10.1097/MD.0000000000038903
  45. Med Oral Patol Oral Cir Bucal. 2024 Aug 01. pii: 26681. [Epub ahead of print]
    Analysis of the citation impact of Brazilian researchers in oral pathology and oral medicine over two decades.
    L-M Ferreira, Á-A Sousa, J-P Nascimento, F-E Oliveira, D-R Martelli, E-A Oliveira, H Martelli-Júnior.
      BACKGROUND: Brazilian Oral Pathology (OP) and Oral Medicine (OM) have gained significant international recognition. However, no study has yet evaluated the impact of citations in scientific publications. Therefore, this study aimed to analyze the impact of citations from Brazilian researchers in OP and OM over the last two decades.MATERIAL AND METHODS: This was a cross-sectional study involving 50 researchers linked to postgraduate programs in OP/OM. Data collected from each professional's Lattes curriculum included gender, academic affiliation, the corporate category of the institution, and location. The number of papers published and citations received between 2004 to 2013 and 2014 to 2023 was also collected from the Web of Science database.
    RESULTS: Most researchers were male (56%) and from public institutions (90%), mainly in the Southeast region (60%). Over two decades, they collectively published 8,033 scientific articles, with significant growth (p<0.001) from to 2004-2013 to 2014-2023. While the average citations per researcher did not differ significantly between 2004-2013 and 2014-2023 (p=0.538), there was a notable 67.67% increase in citations in the last decade.
    CONCLUSIONS: Brazilian researchers in the areas of OP and OM have demonstrated a significant academic impact over the past two decades, with a marked increase in publications and citations over the last ten years. This highlights the contribution of Brazilians to the global scientific community in these areas.
    DOI:  https://doi.org/10.4317/medoral.26681
  46. Pak J Med Sci. 2024 Aug;40(7): 1315-1318
    Journal Citation Report 2024 and Impact Factor of Pakistani Biomedical Journals: Grading impact and analysis.
    Sultan Ayoub Meo, Shaukat Ali Jawaid.
      
    DOI:  https://doi.org/10.12669/pjms.40.7.10399
  47. Technol Health Care. 2024 Jul 24.
    Immunotherapy and liver cancer research trends and the 100 most cited articles: A bibliometric analysis.
    Yang Kong, Yizhi Wang, Qifan Yang, Song Ye.
      BACKGROUND: Bibliometric analysis of liver cancer research, particularly in immunotherapy, reveals crucial insights. The US leads in liver cancer mortality but ranks fifth globally.OBJECTIVE: Scopus database analysis identified 2,349 papers, with the top 100 ranging from 127 to 4,959 citations. Notably, "Microenvironmental Regulation of Tumours Progression and Metastasis" in the Journal of Nature Medicine garnered the highest citations.
    METHODS: Journals like the Journal of Hepatology, Hepatology, and Nature Reports Clinical Oncology contributed significantly. Understanding molecular mechanisms and prognostic indicators is paramount for advancing combination therapies.
    RESULTS: For better patient outcomes, research trends in liver cancer immunotherapy point to improved treatment protocols, knowledge of the tumor microenvironment, combining therapies, predicting disease course, international cooperation, sophisticated surgical techniques, early detection, oncolytic virotherapy, and patient-centered care.
    CONCLUSIONS: This research underscores immunotherapy's pivotal role and encourages further exploration, offering valuable insights into liver cancer treatment trends.
    Keywords:  Liver cancer; bibliometric analysis; immunotherapy; oncology; research trends
    DOI:  https://doi.org/10.3233/THC-241111
  48. Biomedica. 2024 05 31. 44(Sp. 1): 139-150
    Knowledge domains and emerging trends in non-invasive brain stimulation: A bibliometric analysis via CiteSpace
    Inmaculada Ruiz-López, Desirée Victoria-Montesinos, Juan Martínez-Fuentes.
      INTRODUCTION: In recent decades, new non-invasive brain stimulation techniques and protocols have been developed, such as transcranial magnetic stimulation and transcranial direct current stimulation.OBJECTIVE: To identify and visualize the intellectual structure of non-invasive brain stimulation through document co-citation analysis.
    MATERIALS AND METHODS: We analyzed 30,854 Web of Science-indexed manuscripts and their 1,615,692 references regarding non-invasive brain stimulation, all published from 1988 to 2022. We drew a document co-citation network map using CiteSpace software.
    RESULTS: The most productive journal was Clinical Neurophysiology. The most published institution was the University College London, and the country with the most reports was the USA. The most productive author was Alvaro Pascual-Leone and the most cited author in the non-invasive brain stimulation field was J. C. Rothwell. In addition, the most cited study was that of Rossi et al. (2009). The safe application of non-invasive brain stimulation techniques and their effects on motor or executive functions is an emerging trend in this research area.
    CONCLUSIONS: The current investigation displayed a quantitative scientometric approach and delved into the advancement of non-invasive brain stimulation research by examining the references published in this domain. These findings can be valuable for professionals to picture the patterns of recognition and emerging directions in the field.
    Keywords:  transcranial magnetic stimulation; bibliometrics
    DOI:  https://doi.org/10.7705/biomedica.7040
  49. Cureus. 2024 Jun;16(6): e63458
    Study on the Analysis of Gender Trends Among the First Authors of Publications on Budd-Chiari Syndrome.
    Marina Samuel B, Aditya Parag Chitnavis, Rajesh Yadavalli, Sai Kiran Attuluri, Keval Thakkar.
      INTRODUCTION: Budd-Chiari syndrome (BCS) is primarily a disease of hepatic vein blockage, which involves a backflow of blood to the liver. Although there have been many causes linked to this disease, most commonly, it occurs due to hypercoagulable states and blood disorders. In recent times, there has been a fast spread of knowledge regarding early diagnosis and various treatment modalities, which has enabled the prevention of mortality in most cases. This has primarily spread through research articles published in various journals. Thus, the article aims to compare the gender trend ratios to identify the associated discrepancies in terms of male and female author contributions who have been the primary authors for articles pertaining to this disease.  Methodology: A PubMed database between the years 2013 and 2022 was used for the bibliometric analysis. The gender of the primary author was analyzed by NamSor, an application programming interface (API). The statistical analysis was conducted using R software, the ARIMA model, and graphs were prepared using Datawrapper.RESULTS: Out of 667 articles extracted, the analysis showed that there were 455 (68.2%) first male authors and 212 (31.8%) first female authors. We also formulated various other results, which depicted a higher female-to-male author ratio including various journals and different countries. Although there has been an increasing trend of male authors as compared to female authors, this study found that male authorship for research on this disease is still higher.
    CONCLUSIONS: This study depicts that there is a necessity to draw attention to the inequitable systems favoring men over women for publications. The predictive analysis conducted also helps to foresee the trend in the next few years and explains the necessity of addressing the disparities among both genders in healthcare systems.
    Keywords:  authorship; budd-chiari syndrome; disparities; gender trends; statistical model
    DOI:  https://doi.org/10.7759/cureus.63458
  50. J Diabetes Sci Technol. 2024 Jul 30. 19322968241267855
    Thirteen Years JDST: A Quite Nice Ride.
    Lutz Heinemann.
      
    Keywords:  diabetes technology; impact factor; medical journals
    DOI:  https://doi.org/10.1177/19322968241267855
  51. Asian J Surg. 2024 Jul 27. pii: S1015-9584(24)01570-7. [Epub ahead of print]
    Global research trends and frontiers in regulatory T cells within ovarian cancer: A bibliometric and visual analysis.
    Lu Zhou, Mei Liu, Rutie Yin.
      
    Keywords:  Bibliometrics analysis; CiteSpace; Ovarian cancer; Regulatory t cells; VOSviewer
    DOI:  https://doi.org/10.1016/j.asjsur.2024.07.197
  52. Asian J Surg. 2024 Jul 29. pii: S1015-9584(24)01633-6. [Epub ahead of print]
    The interaction between liver cancer and intestinal microbiome: Global research status and trends.
    Yang Xu, Shuai Shao, JinMing Guan, Xin Chen.
      
    Keywords:  Bibliometric analysis; Citespace; Intestinal microbiome; Liver cancer; Scimago Graphica; Vosviewer
    DOI:  https://doi.org/10.1016/j.asjsur.2024.07.260
  53. Am J Ophthalmol. 2024 Jul 31. pii: S0002-9394(24)00331-3. [Epub ahead of print]
    Geographical Trends in Global Ophthalmology Research from 2002-2022.
    Selina J Chang, Amrish Selvam, Sydney DeVore, Rajan Alagar, Amy Yu, Joshua Ong, Jay K Chhablani.
      PURPOSE: Characterize geographical trends in ophthalmology research between 2002-2022 and explore associations between study locations, designs, and funding sources DESIGN: Trend study METHODS: Analysis of 4199 publications from American Journal of Ophthalmology, British Journal of Ophthalmology, Investigative Ophthalmology and Visual Science, JAMA Ophthalmology, and Ophthalmology. All original full-length publications from 2002, 2012, and 2022 were included. Exclusion criteria were meta-analyses, literature reviews, and case reports. Main outcome measures were publication years, locations, study designs, and funding sources.RESULTS: Publications from North America (45.8%), Europe (30.7%), and Asia (28.9%) were the most common, whereas Africa (0.8%) and South America (1.4%) were least represented. North American research decreased by 10.6% (p < 0.001), whereas Asian research increased by 25.4% (p < 0.001). The USA contributed 42.3% of research but experienced a 11.3% decline from 2002-2022 (p < 0.001). USA publications received 5.8% more industry funding from 2002-2022 (p = 0.006). China's research grew by 17.0% and had the highest proportion of government (83.1%) or intramural (24.2%) funding (p < 0.001), with government-funded studies increasing by 46.7% (p < 0.001). Japan was less associated with all funding types (p ≤ 0.001). Singapore, Iceland, and Switzerland were top performers when adjusted for population size.
    CONCLUSIONS: Within the examined journals, the USA remains the primary research contributor, with China witnessing rapid growth and Japan facing stagnation. Despite the USA's declining research proportion, North America and Europe continue to maintain a disproportionately high presence in prestigious academic journals. Publications from Africa and South America are limited.
    DOI:  https://doi.org/10.1016/j.ajo.2024.07.027
  54. Discov Oncol. 2024 Aug 02. 15(1): 329
    Antibody-drug conjugates for breast cancer: a bibliometric study and clinical trial analysis.
    Mengjie Xing, Zhiyi Li, Yuwan Cui, Minghua He, Yang Xing, Lei Yang, Ziling Liu, Linzhi Luo, Hong Wang, Rui Guo.
      BACKGROUND: Breast cancer (BC) remains the most commonly malignancy among women worldwide. Although early-stage BC typically presents with curative possibilities, advanced-stage disease, especially with metastasis, is significantly limited in terms of effective therapeutic interventions, thereby establishing it as the second leading cause of cancer-related deaths in women. Antibody-Drug Conjugates (ADCs) establish a groundbreaking class of anti-neoplastic agents characterized by high specificity and targeting precision. These agents have been significant in reshaping the therapeutic approach to breast cancer, especially those subtypes with overexpression of the Human Epidermal Growth Factor Receptor 2 (HER2). Comprising monoclonal antibodies, cytotoxic payloads, and conjugative linkers, ADCs function by specifically targeting antigens on cancer cells, thereby facilitating the intracellular delivery of the toxic payload. The present investigation endeavors to synthesize existing primary research outcomes through rigorous bibliometric and data analytical approaches, thereby elucidating the current research landscape, delineating research foci, and identifying potential avenues for future innovation.METHODS: For bibliometric analysis, a comprehensive data set comprising 2181 entries related to ADCs in breast cancer was retrieved from the Web of Science Core Collection (WoSCC) spanning the years 1999 to 2023. This data was further filtered from the Science Citation Index Expanded (SCI-Expanded). Analysis software tools such as CiteSpace and VOSviewer were employed for multifaceted analyses such as trends of publications, contributions of countries, and burst analytics. In the dimension of clinical trials, we interrogated databases including ClinicalTrials.gov ( https://www.
    CLINICALTRIALS: gov ) and the WHO International Clinical Trials Registry Platform (ICTRP) ( https://trialsearch.who.int ). A total of 239 clinical trials were initially sourced, among which, 175 were from ClinicalTrials.gov and 64 from ICTRP. After repetitive and correlation-based screening, 119 trials specifically addressing ADC therapeutic strategies in breast cancer were included. Analytical algorithms were executed using Microsoft-based software to evaluate treatment paradigms, emergent research themes, and progress.
    RESULTS: Our investigations signify a growing trend of research on ADCs, with consistent advancements in scientific achievements. The analysis revealed that variables such as economic stratification of nations, healthcare investment paradigms, and disease incidence rates serve as significant determinants in shaping research output. Geographically, the United States emerged as the predominant contributor to the research corpus (36.56%), closely followed by China (21.33%). The underpinning of research accomplishments was found to be significantly bolstered by advancements in molecular biology, immunology, and genetic research. Moreover, the advent of nuclear magnetic resonance diagnostic modalities has contributed saliently to the diagnostic and therapeutic management of breast cancer.
    CONCLUSION: Our study provides a comprehensive overview of the ADC research landscape through rigorous bibliometric and clinical trial evaluations. At present, the ADC arena has witnessed the successful development and FDA approval of 14 distinct agents, substantially improving the clinical outcomes for a broad spectrum of oncological patients. Future research imperatives may include the exploration of ADCs targeting mutated oncoproteins, dual-specificity ADCs, combination payload strategies, peptide-drug conjugates (PDCs), and non-internalizing ADC modalities. With sustained academic and clinical focus, the ADC domain is poised for transformative advancements in targeted therapeutics across a variety of malignancies.
    DOI:  https://doi.org/10.1007/s12672-024-01192-w
  55. World J Clin Oncol. 2024 Jul 24. 15(7): 867-894
    Bibliometric analysis of phosphoglycerate kinase 1 expression in breast cancer and its distinct upregulation in triple-negative breast cancer.
    Jing-Yu Chen, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Gang Chen, Wen Zou.
      BACKGROUND: Phosphoglycerate kinase 1 (PGK1) has been identified as a possible biomarker for breast cancer (BC) and may play a role in the development and advancement of triple-negative BC (TNBC).AIM: To explore the PGK1 and BC research status and PGK1 expression and mechanism differences among TNBC, non-TNBC, and normal breast tissue.
    METHODS: PGK1 and BC related literature was downloaded from Web of Science Core Collection Core Collection. Publication counts, key-word frequency, cooperation networks, and theme trends were analyzed. Normal breast, TNBC, and non-TNBC mRNA data were gathered, and differentially expressed genes obtained. Area under the summary receiver operating characteristic curves, sensitivity and specificity of PGK1 expression were determined. Kaplan Meier revealed PGK1's prognostic implication. PGK1 co-expressed genes were explored, and Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Disease Ontology applied. Protein-protein interaction networks were constructed. Hub genes identified.
    RESULTS: PGK1 and BC related publications have surged since 2020, with China leading the way. The most frequent keyword was "Expression". Collaborative networks were found among co-citations, countries, institutions, and authors. PGK1 expression and BC progression were research hotspots, and PGK1 expression and BC survival were research frontiers. In 16 TNBC vs non-cancerous breast and 15 TNBC vs non-TNBC datasets, PGK1 mRNA levels were higher in 1159 TNBC than 1205 non-cancerous breast cases [standardized mean differences (SMD): 0.85, 95% confidence interval (95%CI): 0.54-1.16, I² = 86%, P < 0.001]. PGK1 expression was higher in 1520 TNBC than 7072 non-TNBC cases (SMD: 0.25, 95%CI: 0.03-0.47, I² = 91%, P = 0.02). Recurrence free survival was lower in PGK1-high-expression than PGK1-low-expression group (hazard ratio: 1.282, P = 0.023). PGK1 co-expressed genes were concentrated in ATP metabolic process, HIF-1 signaling, and glycolysis/gluconeogenesis pathways.
    CONCLUSION: PGK1 expression is a research hotspot and frontier direction in the BC field. PGK1 may play a strong role in promoting cancer in TNBC by mediating metabolism and HIF-1 signaling pathways.
    Keywords:  Bibliometric analysis; Breast cancer; Computational pathology; Phosphoglycerate kinase 1; Triple-negative breast cancer
    DOI:  https://doi.org/10.5306/wjco.v15.i7.867
  56. J Bone Joint Surg Am. 2024 Aug 01.
    Academic and Demographic Profile of Orthopaedic Vice Chairs of Research: Implications for Leadership.
    Seetha Aribindi, Philipp Leucht, Wellington K Hsu, Addisu Mesfin.
      BACKGROUND: Vice chairs (VCs) of research play an integral role in orthopaedic departments at academic medical centers; they strategically lead research efforts and support the research careers of faculty and trainees. To our knowledge, no analysis of orthopaedic VCs of research exists in the literature, and no similar analyses have been completed in other medical specialties. We aimed to investigate the academic and demographic characteristics of orthopaedic VCs of research.METHODS: Doximity was used to identify orthopaedic residencies in the U.S. Personal and program websites were queried to identify VCs of research and collect academic and demographic characteristics. The Scopus database, the National Institutes of Health (NIH) RePORTER, and Google Scholar were used to obtain each investigator's Hirsch index (h-index) and the number and type of NIH grants awarded, respectively.
    RESULTS: Of the 207 orthopaedic residency programs identified, 71 (34%) had a named VC of research in the orthopaedic department. Of the top 50 medical schools, 42 were affiliated with such programs. Most VCs were men (89%). The racial and/or ethnic background of the majority of VCs was White (85%), followed by Asian (14%), and Black (1%). Most held the rank of professor (78%), followed by associate professor (18%), and assistant professor (4%). Over half were PhDs (55%), followed by MDs (37%) and MD/PhDs (8%). On average, the VCs had an h-index of 40.5. Furthermore, 65% had been awarded at least 1 NIH grant for their research, with 43% awarded at least 1 R01 grant.
    CONCLUSIONS: VCs of research develop research opportunities and shape the brand recognition of academic orthopaedic programs. Most orthopaedic VCs of research are men (89%); 85% each are White and have a rank of professor. Nearly half have been awarded at least 1 R01 grant from the NIH.
    CLINICAL RELEVANCE: This study outlines important academic and demographic characteristics among orthopaedic surgery VCs of research. Considering the mentorship aspect of their role, VCs of research have an opportunity to influence the diversity of incoming trainees in the field of academic orthopaedics.
    DOI:  https://doi.org/10.2106/JBJS.23.01296
  57. Ann Biomed Eng. 2024 Aug 02.
    Academic Citation Partnership: A Predatory Practice that Undermines Scholarly Integrity.
    Louie Giray.
      Recently, academic circles have raised concerns about academic citation partnerships. Many researchers receive emails offering these partnerships, often landing in their spam folders. In this paper, I refer to academic citation partnerships as unethical collaborative arrangements where researchers or authors agree to cite each other's work in their academic publications to enhance their academic profiles, often measured by metrics like the h-index. I discuss the characteristics of such partnerships, individuals, and groups who are commonly involved in academic citation partnerships, and clarify what is not considered an academic citation partnership. I argue that these partnerships are predatory and pose a serious threat to scholarly integrity. Such solicitations blur ethical boundaries by treating citations as commodities, similar to predatory journals and conferences. These partnerships compromise the authenticity of scholarly discourse, artificially inflate perceived impacts, and distort academic evaluations. They undermine the pursuit of knowledge for its intrinsic value and exacerbate inequalities in academia by favoring those who can manipulate citation metrics through resources or networks. Addressing this issue requires a commitment to vigilance and adherence to ethical citation standards, ensuring academic discourse that is intellectually honest and genuinely beneficial to academia.
    Keywords:  Academic citation partnership; Citation commodification; Ethical standards; Ethics; Scholarly integrity; h-index
    DOI:  https://doi.org/10.1007/s10439-024-03598-7
  58. Aesthetic Plast Surg. 2024 Jul 31.
    Global Landscape of Platelet-Rich Plasma Research in Medical Dermatology: A Visualized Bibliometric Analysis (2004-2023).
    Sa'ed H Zyoud.
      Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    DOI:  https://doi.org/10.1007/s00266-024-04291-9
  59. Rev Bras Enferm. 2024 ;pii: S0034-71672024000700302. [Epub ahead of print]77(3): e20230452
    Profile of scientific production on nursing technology construction, validity and application: a bibliometric study.
    Fernando Conceição de Lima, Taís Dos Passos Sagica, João Lucas Moraes Souza, Marta Lenise do Prado, Mary Elizabeth de Santana, Ivonete Vieira Pereira Peixoto, Rubenilson Caldas Valois.
      OBJECTIVE: to analyze the profile of scientific production on nursing technology construction, validity and application.METHODS: this is a bibliometric study, carried out in six databases, based on the Methodi Ordinatio application, arranged in nine stages. To represent the findings, the VOSviewer® software was used.
    RESULTS: 346 studies were identified, obtained from BDENF, CINAHL, EMBASE, LILACS, PubMed/MEDLINE, Scopus and Web of Science. There was a predominance of the English language, and 20% of the authors hold more than 25% of studies. Only two journals account for 25% of studies in the period studied. Twenty-six studies were selected for the InOrdinatio classification. Nursing Process (23%) stood out among the studies. The most produced technology was software (27%), and 50% of works describe construction and validity.
    CONCLUSIONS: there is an emphasis on the creation of educational technologies, especially information technology. The data demonstrates opportunities for future research in the area.
    DOI:  https://doi.org/10.1590/0034-7167-2023-0452
  60. Cephalalgia. 2024 Aug;44(8): 3331024241266980
    Comment on "What predicts citation counts and translational impact in headache research? A machine learning analysis".
    Igor Petrušić, Paolo Martelletti.
      
    DOI:  https://doi.org/10.1177/03331024241266980
  61. Clin Neuropsychol. 2024 Aug 03. 1-15
    Cultural and multicultural topics in Neuropsychology Journal titles from 2010-2020.
    Rebecca E Ready, Eleni Kapoulea, Irina Orlovsky, Maya Whaley, Hanan S Rafiuddin.
      OBJECTIVE: The values of a field are reflected in the science it publishes. The goal of this study was to present a historical analysis of the extent to which the field of clinical neuropsychology publishes journals with titles that address culture in the context of brain function and behavior between 2010 and 2020.METHODS: Titles from articles published in 13 neuropsychology journals from 2010-2020 were collected and coded with regard to culture and multicultural content. The aims of the study were to (1) determine how often cultural or multicultural topics were represented in journal titles, (2) determine if cultural or multicultural content in neuropsychology journal publication titles increased over time, and (3) to explore other neuropsychological content that was most and least likely to appear in publications pertaining to culture or multicultural issues.
    RESULTS: Results indicated that titles for publications in clinical neuropsychology journals with content relevant to cultural or multicultural neuropsychology represented 1.1% to 13.4% of titles across the 13 journals. The number of cultural/multicultural titles increased over time. The number of cultural/multicultural titles per journal was not significantly correlated with the journal impact factor. Normative data were addressed significantly more often in cultural/multicultural titles versus non-cultural/multicultural titles, whereas psychiatric issues were addressed significantly less often.
    CONCLUSIONS: There are many actions that clinical neuropsychologists can take to increase the field's attention to the effects of culture on brain function and behavior. It is vital to update our data from 2021 to the present, given the substantial increase in awareness of social justice issues that occurred since 2020.
    Keywords:  Neuropsychology; culture; impact factor; multicultural; normative data
    DOI:  https://doi.org/10.1080/13854046.2024.2385506
  62. Int J Biol Macromol. 2024 Jul 20. pii: S0141-8130(24)04633-6. [Epub ahead of print] 133828
    Bibliometric study and potential applications in the development of starch films with nanocellulose: A perspective from 2019 to 2023.
    Jocilane Pereira de Oliveira, Isaac Borges da Silva, Jéssica da Silva Santos Costa, Jéssica Santos de Oliveira, Esaul Lucas Oliveira, Mateus Lima Coutinho, Maria Elis Ferreira de Almeida, Lucas Brito Landim, Normane Mirele Chaves da Silva, Cristiane Patrícia de Oliveira.
      This study aimed to perform a bibliometric analysis of starch films with nanocellulose, using the Scopus database and VOSviewer and Bibliometrix software. A total of 258 documents were identified between 2019 and 2023, reflecting a growing interest in research, particularly in journals such as the International Journal of Biological Macromolecules, Polymers, and Carbohydrate Polymers. The most common terms were "starch" (349 occurrences), "cellulose" (207), and "tensile strength" (175). China (58 articles), Brazil (38), and India (33) led scientific production, with authors like Ilyas (13 articles) and Sapuan (10) at the forefront. Approximately 41.7 % of the studies used corn starch. The analysis revealed that 66 % of the studies investigated films with cellulose nanofibrils (CNF), 32 % with cellulose nanocrystals (CNC), and 2 % with bacterial nanocellulose (CB). The majority of studies (94.1 %) used the casting method for film production. Additionally, 35.44 % focused on reinforcing films with nanocellulose, while 7 % developed blends with other biopolymers. About 59.44 % examined the performance of starch films for food packaging, 11.25 % explored practical applications in various foods. Furthermore, 7.94 % incorporated active agents to improve antioxidant and antimicrobial properties, 1.30 % investigated active packaging. Moreover, 2.36 % explored the use of films in materials engineering, and 2.36 % explored biomedical potential. Only 0.40 % evaluated the impact of films on wastewater treatment. The analysis highlights the potential of starch films with nanocellulose, demonstrating their diverse applications and the growing interest in the field.
    Keywords:  Cellulose derivatives; Nanocomposites; Starch packaging
    DOI:  https://doi.org/10.1016/j.ijbiomac.2024.133828
  63. Skin Res Technol. 2024 Jul;30(7): e13860
    Amniotic miracle: Investigating the unique development and applications of amniotic membrane in wound healing.
    Xinya Guo, Wei Zhang, Jianyu Lu, Yushu Zhu, Hanlin Sun, Dayuan Xu, Shuyuan Xian, Yuntao Yao, Weijin Qian, Bingnan Lu, Jiaying Shi, Xiaoyi Ding, Yixu Li, Xirui Tong, Shichu Xiao, Runzhi Huang, Shizhao Ji.
      BACKGROUND: The perfect repair of damaged skin has always been a constant goal for scientists; however, the repair and reconstruction of skin is still a major problem and challenge in injury and burns medicine. Human amniotic membrane (hAM), with its good mechanical properties and anti-inflammatory, antioxidant and antimicrobial benefits, containing growth factors that promote wound healing, has evolved over the last few decades from simple skin sheets to high-tech dressings, such as being made into nanocomposites, hydrogels, powders, and electrostatically spun scaffolds. This paper aims to explore the historical development, applications, trends, and research hotspots of hAM in wound healing.METHODS: We examined 2660 publications indexed in the Web of Science Core Collection (WoSCC) from January 1, 1975 to July 12, 2023. Utilizing bibliometric methods, we employed VOSviewer, CiteSpace, and R-bibliometrix to characterize general information, identify development trends, and highlight research hotspots. Subsequently, we identified a collection of high-quality English articles focusing on the roles of human amniotic epithelial stem cells (hAESCs), human amniotic mesenchymal stem cells (hAMSCs), and amniotic membrane (AM) scaffolds in regenerative medicine and tissue engineering.
    RESULTS: Bibliometric analysis identified Udice-French Research Universities as the most productive affiliation and Tseng S.C.G. as the most prolific author. Keyword analysis, historical direct quotations network, and thematic analysis helped us review the historical and major themes in this field. Our examination included the knowledge structure, global status, trends, and research hotspots regarding the application of hAM in wound healing. Our findings indicate that contemporary research emphasizes the preparation and application of products derived from hAM. Notably, both hAM and the cells isolated from it - hADSCs and hAESCs are prominent and promising areas of research in regenerative medicine and tissue engineering.
    CONCLUSION: This research delivers a comprehensive understanding of the knowledge frameworks, global dynamics, emerging patterns, and primary research foci in the realm of hAM applications for wound healing. The field is rapidly evolving, and our findings offer valuable insights for researchers. Future research outcomes are anticipated to be applied in clinical practice, enhancing methods for disease prevention, diagnosis, and treatment.
    Keywords:  amniotic membrane; bibliometrics; tissue engineering; wound healing
    DOI:  https://doi.org/10.1111/srt.13860
  64. Brain Spine. 2024 ;4 102851
    Brain and spine has an impact factor.
    Frank Kandziora, Wilco Peul.
      
    DOI:  https://doi.org/10.1016/j.bas.2024.102851
  65. BMC Med Educ. 2024 Aug 02. 24(1): 836
    The impact of a curriculum-based research training program on medical students' research productivity and future research interests: a longitudinal study.
    Jing Shen, Hongyan Qi, Guiling Liu, Xuyun Li, Yu Fang.
      BACKGROUND: Incorporating scientific research into undergraduate medical education is necessary for the quality of future health care. However, providing rigorous research training to a large number of medical students at one institution remains one of the major challenges. The authors studied the impact of a curriculum-based Research Training Program (RTP) for all undergraduate students at Zhejiang University School of Medicine (ZUSM) on research productivity and future research interests.METHODS: Medical students (n = 2,213) from ZUSM who completed the course of RTP between 2013 and 2020 were studied. The authors measured the academic performance, research publications, and research projects of students across years, and evaluated potential factors that contribute to student research productivity and increased interest in future research.
    RESULTS: Across the years, there was an increase in the number of student publications, a greater proportion of students with publications, and a greater proportion of projects involving three or more students (P < .01 for all). The academic performance of the course was associated with increased publications (P = .014), whereas overall satisfaction of the course (OR 2.07, 95% CI [1.39, 3.10], P < .001), Skill Composite Score (SCS) (OR 1.70, 95% CI [1.16, 2.50], P = .007), and male gender (OR 1.50, 95% CI [1.06, 2.12], P = .022) were associated with increased future research interests.
    CONCLUSIONS: The findings suggest that the curriculum-based RTP improved students' research productivity, and that overall program satisfaction and self-assessed performance were associated with increased students' intent to participate in future research.
    Keywords:  Curriculum-based research program; Research interests; Research productivity; Undergraduate medical education
    DOI:  https://doi.org/10.1186/s12909-024-05841-0
  66. R Soc Open Sci. 2024 May;11(5): 231521
    A memory-theoretic account of citation propagation.
    Michael R Dougherty, David A Illingworth, Rosalind Nguyen.
      Despite the common assumption that citations are indicative of an article's scientific merit, increasing evidence indicates that citation counts are largely driven by variables unrelated to quality. In this article, we treat people's decisions of what to cite as an instance of memory retrieval and show that observed citation patterns are well accounted for by a model of memory. The proposed exposure model anticipates that small alterations in factors that affect people's ability to retrieve to-be-cited articles from memory early in their life cycle are magnified over time and can lead to the emergence of highly cited papers. This effect occurs even when there is no variation in the starting point exposure probabilities (i.e. when assuming a level playing field where all articles are treated equally and of equal 'quality'), and is exacerbated by natural variation in retrievability of articles due to encoding. We discuss the implications of the model within the context of research evaluation and hiring, tenure and promotion decisions.
    Keywords:  bibliometrics; citation counts; information search; memory; research evaluation
    DOI:  https://doi.org/10.1098/rsos.231521
  67. Neurosurg Rev. 2024 Jul 31. 47(1): 380
    Democratizing neurosurgical knowledge: a call for publishing reform.
    Shajia Khan, Eesha Yaqoob, Bipin Chaurasia, Saad Javed.
      Publishing a scientific article in good journals with good Impact factor has become very difficult these days. This is not all depend on the quality of article. Most of times it's the lack of ability to pay the article processing fee. In Low and middle income countries (LMIC) it becomes more difficult as the research is not supported by government and institutions. Here we delve into the real problems of research article publication in LMIC.
    DOI:  https://doi.org/10.1007/s10143-024-02616-5
  68. J Transl Int Med. 2024 Jun;12(3): 225-243
    A bibliometric analysis of immune-related adverse events in cancer patients and a meta-analysis of immune-related adverse events in patients with hepatocellular carcinoma.
    Bengang Wang, Xiangjun Hao, Jinshan Yan, Xin Li, Mingfang Zhao, Tao Han.
      Background and Objectives: Immunotherapy has become the standard treatment for hepatocellular carcinoma (HCC), but it carries a risk of immune-related adverse events (irAEs) that can be life-threatening. This study employs bibliometric analysis to understand global scientific research on irAEs in cancer, focusing on characteristics and areas of interest. Additionally, a meta-analysis provides a comprehensive overview of irAEs in HCC patients receiving immune checkpoint inhibitor (ICI)-based therapies.Methods: We conducted a thorough search of Web of Science Core Collection (WoSCC) publications from 1999 to 2022. R and VOSviewer software were used for analysis. A meta-analysis was performed using data from PubMed, Embase, and the Cochrane Library databases up to March 22, 2022. Trials with HCC patients reporting irAE incidence were included. Quality assessment followed Cochrane risk of bias, Newcastle-Ottawa Scale (NOS), and Methodological Index for Non-Randomized Studies (MINORS). We used random-effects or fixed-effects models based on I2 values. Primary outcomes included any-grade irAEs and grade ≥ 3 irAEs. This review and meta-analysis are registered in PROSPERO as CRD42022318885.
    Results: In bibliometric analysis, we included 2946 papers, showing a consistent rise in annual publications on irAEs in cancer research. Frequent keywords were "nivolumab", "immune checkpoint inhibitor", and "immune-related adverse event". "Hepatocellular carcinoma" emerged as a prominent research focus linked to irAEs. We conducted a comprehensive meta-analysis on irAE incidence in HCC patients, including 29 studies. The overall incidence of any-grade irAEs was 61.0% (95% CI 38.5%-81.3%), and grade ≥ 3 irAEs was 13.2% (95% CI 7.9%-19.6%). Treatment-related mortality occurred in 3.1% (95% CI 0.8%-6.3%), with treatment discontinuation at 10.7% (95% CI 6.3%-16.0%). Reactive cutaneous capillary endothelial proliferation (RCCEP) was the most common any-grade irAE, while elevated aspartate aminotransferase (AST) was the most common grade ≥ 3 irAE. Treatment strategies were independently associated with specific irAEs, as indicated by multivariable analysis.
    Conclusion: This study provides valuable insights into the current research landscape of irAEs in cancer and ofers a comprehensive overview of irAEs in HCC patients undergoing ICI-based therapy. The relatively high incidence of irAEs and their association with treatment strategies emphasize the need for careful management by clinicians when treating HCC patients. These findings offer significant guidance for optimizing care and treatment for HCC patients.
    Keywords:  bibliometrics; hepatocellular carcinoma; immune checkpoint inhibitors; immune-related adverse events; single-arm meta-analysis
    DOI:  https://doi.org/10.2478/jtim-2024-0003
  69. Front Biosci (Landmark Ed). 2024 Jul 02. 29(7): 244
    Combining Bibliometric Analysis to Uncover the Detrimental and Protective Roles of Various Dendritic Cell Types in Cardiovascular Arterial Diseases.
    Wenxing Li, Lan Luo, Yue Fan, Xiangling Lv, Qianfeng Jiang, Yang Jiao.
      Immune cell dysregulation is increasingly recognized as a pivotal pathological factor in cardiovascular disease. Over the past decade, a surge of research has focused on the role of immune cells such as dendritic cells (DCs), T cells, macrophages, and neutrophils in cardiovascular diseases, findings that are frequently featured in leading cardiology journals. This review provides a comprehensive synthesis of the roles that DCs play in common and potentially fatal arterial diseases, including hypertension, coronary artery atherosclerosis, acute coronary syndrome, pulmonary arterial hypertension, aortic aneurysm, aortic dissection, and vasculitis. Combining with bibliometric analysis, this review delves into the critical mechanisms by which DCs contribute to these diseases and reveals the shared mechanisms across diverse diseases. This review also offers new advances in clinical treatment strategies involving DCs.
    Keywords:  acute coronary syndrome; chemokines; dendritic cells; hypertension; renin-angiotensin-aldosterone system
    DOI:  https://doi.org/10.31083/j.fbl2907244
  70. J Nepal Health Res Counc. 2024 Jun 22. 22(1): 96-100
    Publication Status of Theses among Post-graduate Students in Nursing from Institute of Medicine.
    Pratima Khatri, Bigya Chapagain, Mohan Raj Sharma.
      BACKGROUND: Publication of the research work done during the master's program is highly desirable. However, there is a paucity of data on the number of publications, especially from low-income countries. The objective was to find out the status of the publication of the theses of post-graduate students in Nursing from the Institute of Medicine, Tribhuvan University, Nepal from 2015-2019.METHODS: Cross-sectional analytical design with a structured interview via telephone was done for data collection. Independent variables were age, marital status, current work status, current working organization, type of research, year of graduation, and facilitators and barriers to publication, whereas dependent was the publication status of the thesis.
    RESULTS: Two hundred five (76.2%) out of 269 participated in the study. The age group ranged from 27 to 50 years (mean ± SD = 36.6±4.8). The majority 89.3% were married. Currently working in academic institutions was 51.7%. One hundred ninety-eight (96.6%) respondents performed a cross-sectional descriptive study. Only 2.9% of studies were cross-sectional analytical and 0.5% were qualitative. Seventy-five (36.6%) respondents published their theses. Twenty-seven (36.0%) were published in PubMed-indexed journals. The most common facilitator for publication was academic satisfaction [59 out of 75(78.7%)] followed by encouragement from supervisors 52.0% and peers 40.0%, whereas the commonest barrier to publication was lack of interest [80 out of 124 (64.5%)] followed by lack of confidence 51.6%.
    CONCLUSIONS: Based on the results, more than one-third of the participants published their theses in national and international journals including those indexed in PubMed. Provision of university research grants, development of publication culture among post-graduate students, and making a provision of academic publication before degree awards should be encouraged for more academic publication.
    Keywords:  Journals; Nepal; nursing; publication status; thesis.
    DOI:  https://doi.org/10.33314/jnhrc.v22i01.4460
  71. Front Oral Health. 2024 ;5 1454579
    Editorial: Women in oral health promotion.
    Morẹ Nikẹ Oluwátóyìn Foláyan, Joana Cunha-Cruz.
      
    Keywords:  gender equality; refugee healthcare; research productivity; sustainable development goals; women in science
    DOI:  https://doi.org/10.3389/froh.2024.1454579
  72. Cancer Prev Res (Phila). 2024 Aug 01. 17(8): 347
    Editors' Selections from Relevant Scientific Publications.
      
    DOI:  https://doi.org/10.1158/1940-6207.CAPR-17-8-HFL
  73. Am J Cardiovasc Drugs. 2024 Aug 01.
    Characteristics and Impact of Randomized Trials on Drugs or Devices in Cardiovascular Medicine.
    Marco Spagnolo, Claudio Laudani, Antonio Greco, Daniele Giacoppo, Davide Capodanno.
      INTRODUCTION: Clinical trials, essential for medical advancement, vary significantly in methodology and regulatory pathways depending on the type of therapeutic intervention (i.e., drugs or devices). This study aimed to determine whether the drug or device intervention types influence the impact of randomized trials in cardiovascular medicine.METHODS: We analyzed late-breaking randomized controlled trials presented at major cardiology conferences from 2015 to 2021. The primary endpoint was the total number of citations obtained. Secondary endpoints included the number of citations at 1 and 2 years, number of total and 1-year mentions, and several metrics of study conduct and publication. Statistical analysis included tests for comparisons of continuous or categorical variables, based on their distribution, as appropriate. To adjust the results for potential confounders, univariable and multivariable regression models were utilized. Additionally, sensitivity analyses were conducted to explore both the effect of neutral or positive study outcomes on the comparative impact of drug versus device trials and the impact of the coronavirus disease 2019 (COVID-19) pandemic on the primary endpoint.
    RESULTS: Of 382 eligible randomized trials, 227 (59.4%) were trials of drugs and 155 (40.6%) were trials of devices. Drug trials had a higher median number of total citations compared to device studies (93 [interquartile range {IQR} 48-137] vs. 82 [IQR 39-192]; p = 0.025). This difference was consistent at 1 and 2 years and was also observed in the number of total mentions and mentions at 1 year. All the metrics of study conduct and publication were similar, except for drug studies being more often stopped prematurely (8.8 vs. 1.9%; p = 0.006). After adjusting for multiple potential confounders, the difference in citations and mentions was no longer statistically significant. However, drug trials remained more likely to be stopped prematurely (adjusted odds ratio = 1.15; 95% confidence interval 1.03-1.28; p = 0.009). Positive study outcomes significantly influenced the number of citations and the likelihood of a trial being stopped prematurely.
    CONCLUSIONS: Drug trials are often stopped early and receive more citations and mentions than device trials. However, these differences are mainly due to factors other than the treatment itself. Studies published simultaneously tend to get more attention, and drug trials with positive results are cited more often than those with neutral results.
    DOI:  https://doi.org/10.1007/s40256-024-00670-4
  74. J Dent. 2024 Jul 30. pii: S0300-5712(24)00444-5. [Epub ahead of print] 105275
    Estimating the Use of ChatGPT in Dental Research Publications.
    Sergio E Uribe, Ilze Maldupa.
      INTRODUCTION: Generative artificial intelligence (GenAI) Large-language models such as ChatGPT have become increasingly popular in various fields. However, the impact of ChatGPT on dental research writing has yet to be quantified. This study aimed to assess ChatGPT's usage in dental research writing and discuss potential advantages and challenges.METHODS: Using a bibliometric design, we performed a keyword analysis of specific 'signaling words' indicative of ChatGPT use in the titles/abstracts of 299,695 dental research abstracts indexed PubMed 2018-2024. Statistical comparisons using normalized ratios per 10,000 dental publications compared changes in word frequency before and after the ChatGPT release on November 30, 2022.
    RESULTS: Before ChatGPT's release, the frequency of abstracts with signaling words was 47.1 per 10,000 papers. After the release, this increased to 224.2 per 10,000 papers, an increase of 177.2 per 10,000 papers (p=0.014, 95% CI 53.5-300.7). The word 'delve' showed the most significant usage increase (increased ratio=17.0).
    CONCLUSIONS: This study is among the first to systematically assess the use of GenAI, specifically ChatGPT, in dental research. We found evidence of the use and growth of ChatGPT in dental research publications. This trend indicates the widespread adoption of GenAI-assisted writing in scientific communication, consistent with other scientific fields. While GenAI can potentially increase productivity and inclusivity, it raises concerns such as bias, inaccuracy, and distortion of academic incentives. Therefore, our findings support the need for clear AI guidelines and standards for academic publishing to ensure responsible use and maintain scientific integrity.
    Keywords:  Artificial intelligence; Large-language model; Scientific Communication, ChatGPT, Dental Research
    DOI:  https://doi.org/10.1016/j.jdent.2024.105275
  75. Nature. 2024 Aug 01.
    These AI firms publish the world's most highly cited work.
    Elizabeth Gibney.
      
    Keywords:  Machine learning
    DOI:  https://doi.org/10.1038/d41586-024-02515-1
  76. Clin Spine Surg. 2024 Aug 02.
    Bibliometric Patent Review of Minimally Invasive Spine Surgery.
    Bashar Zaidat, Wasil Ahmed, Junho Song, Noor Maza, Nancy Shrestha, Rami Rajjoub, Suhas Etigunta, Jun S Kim, Samuel K Cho.
      STUDY DESIGN: This study analyzes patents associated with minimally invasive spine surgery (MISS) found on the Lens open online platform.OBJECTIVE: The goal of this research was to provide an overview of the most referenced patents in the field of MISS and to uncover patterns in the evolution and categorization of these patents.
    SUMMARY OF BACKGROUND DATA: MISS has rapidly progressed, with a core focus on minimizing surgical damage, preserving the natural anatomy, and enabling swift recovery, all while achieving outcomes that rival traditional open surgery. While prior studies have primarily concentrated on MISS outcomes, the analysis of MISS patents has been limited.
    METHODS: To conduct this study, we used the Lens platform to search for patents that included the terms "minimally invasive" and "spine" in their titles, abstracts, or claims. We then categorized these patents and identified the top 100 with the most forward citations. We further classified these patents into 4 categories: Spinal Stabilization Systems, Joint Implants or Procedures, Screw Delivery System or Method, and Access and Surgical Pathway Formation.
    RESULTS: Five hundred two MISS patents were identified initially, and 276 were retained following a screening process. Among the top 100 patents, the majority had active legal status. The largest category within the top 100 patents was Access and Surgical Pathway Formation, closely followed by Spinal Stabilization Systems and Joint Implants or Procedures. The smallest category was Screw Delivery System or Method. Notably, the majority of the top 100 patents had priority years falling between 2000 and 2009, indicating a moderate positive correlation between patent rank and priority year.
    CONCLUSIONS: Thus far, patents related to Access and Surgical Pathway Formation have laid the foundation for subsequent innovations in Spinal Stabilization Systems and Screw Technology. This study serves as a valuable resource for guiding future innovations in this rapidly evolving field.
    DOI:  https://doi.org/10.1097/BSD.0000000000001661
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