bims-evares Biomed News
on Evaluation of research
Issue of 2025–03–23
99 papers selected by
Thomas Krichel, Open Library Society
  1. The global research of artificial intelligence on inflammatory bowel disease: A bibliometric analysis.
  2. Knowledge Landscape and Hotspots of Research in Transthyretin Amyloid Cardiomyopathy: A Bibliometric Analysis.
  3. Immediate Implant and Loading Approaches: Analysis from a Bibliometric Perspective.
  4. From Data to Discovery: A Comprehensive Bibliometric Research on Bone Grafting in Oral Implantology.
  5. The global trend of intravenous anesthesia and tumors: a bibliometric and visualized study.
  6. Enhanced Recovery After Surgery Pathways and Obstetric Anesthesia: A Bibliometric Analysis.
  7. Epidural hematoma: Bibliometric analysis of scientific trends and developments from 1980 to 2023.
  8. A visualization analysis of global research trends in targeted therapies for thyroid carcinoma (2013-2023).
  9. Knowledge mapping of exosomes in preeclampsia: a bibliometric analysis (2008-2023).
  10. Gastric cancer peritoneal metastasis: a bibliometric study from 2000 to 2024 using VOSviewer software.
  11. Trends in Mixed Pain Research Over Three Decades (1993-2024): A Bibliometric Analysis.
  12. Research Trends and Evolution of Astrocytes in Depression and Antidepressant Treatment: A Bibliometric Analysis.
  13. Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now.
  14. Bibliometric studies: Essential navigational tools in today's academic landscape.
  15. Bibliometric analysis of the intestinal microbiota and demyelinating diseases, particularly multiple sclerosis, since 2014.
  16. Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.
  17. The 100 most-cited papers on esthesioneuroblastoma: a bibliometric analysis.
  18. The 100 most influential papers on Lewy body dementias: a bibliometric analysis.
  19. Global trends and research hotspots in acupuncture treatment for cardiovascular diseases over the past decade: a bibliometric study.
  20. Research progress and hotspot analysis of type B aortic dissection: a bibliometric analysis from 2004 to 2023.
  21. Hotspots and Trends in Allergic Rhinitis Nasal Mucosa Studies: A Bibliometric Analysis (2010-2024).
  22. Measuring Medical Student Scholarly Activity After a Structured Plastic Surgery Research Fellowship: A Bibliometric Analysis.
  23. Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis.
  24. Advances and global trends of precancerous lesions of gastric cancer: A bibliometric analysis.
  25. Knowledge mapping and visualized analysis of research progress in onconephrology: a bibliometric analysis.
  26. Progress in ubiquitination and hepatocellular carcinoma: a bibliometric analysis.
  27. Bibliometric analysis of Crohn's disease in children, 2014-2024.
  28. Shifting landscapes of gender equity in oncology journals: a decade of authorship trends.
  29. Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013-2023).
  30. Knowledge mapping of Guillain-Barré syndrome from January 2013 to October 2023: A bibliometric analysis.
  31. Machine learning in solid organ transplantation: Charting the evolving landscape.
  32. Knowledge mapping for prediction of spontaneous preterm birth.
  33. Research trends of neoadjuvant therapy in lung cancer: a bibliometric analysis.
  34. Ultrasound-guided thermal ablation therapy for papillary thyroid carcinoma: a bibliometric analysis from 2000 to 2023.
  35. Analyzing research trends in the relationship between immunosuppressants and cancer following organ transplantation: a bibliometric study from 2001 to 2023.
  36. A bibliometric analysis of current research, development status, and future development trends of soy and whey proteins.
  37. Temporal trends in diagnostic evolutions for rickettsial diseases including scrub typhus: a bibliometric study.
  38. Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis.
  39. Mapping the landscape of neuroscience research trend(s) in South Asia: A bibliometric analysis of 25 years (1995-2019).
  40. Global output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping.
  41. The Current Status, Hotspots, and Development Trends of Nanoemulsions: A Comprehensive Bibliometric Review.
  42. Knowledge domain and emerging trends in post-stroke cognitive impairment: a bibliometric analysis.
  43. Immunotherapy research in the Arab world: A bibliometric analysis.
  44. Chemotherapy against Toxoplasma gondii: A bibliometric analysis of in vitro and mouse model studies (2015-2024).
  45. Research Trends of Tyrosine Kinase Inhibitors in EGFR-Mutated Non-Small Cell Lung Cancer: A Bibliometric Analysis.
  46. Global trends and hotspots in macrophage research related to hypertension from 2015-2024: bibliometric research and visualization analysis.
  47. Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots.
  48. Global Bibliometric Visualization of Epidermal Growth Factor in Wound Healing: A Comprehensive Literature Search.
  49. Management of the Brain Death Organ Donor: Results of a Comprehensive Bibliometric Analysis on Research, 1992-2024.
  50. Bibliometric and visualized analysis of research hotpots and future prospects in lacrimal duct obstruction disease (1900 to 2024).
  51. Research progress and visual analysis of smart wearable devices for the elderly in the context of ageing 4.0.
  52. A visualization analysis of research on arterial compression hemostatic devices using VOSviewer and CiteSpace.
  53. Research status of risk factors and prevention of pancreatic cancer: A bibliometric and visual analysis.
  54. Research and Application Prospect of Nanomedicine in Kidney Disease: A Bibliometric Analysis From 2003 to 2024.
  55. Application of Mendelian randomized analysis method in Vitamin D research: A 10-year bibliometric analysis.
  56. Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis.
  57. Systematic bibliometric and visualized analysis of research hotspots and trends in obstructive sleep apnea neuroimaging.
  58. Lessons from the similarities and differences in fluid resuscitation between burns and sepsis: a bibliometric analysis.
  59. The Role of Virtual Reality on Parkinson's Disease Management: A Bibliometric and Content Analysis.
  60. Exploring the evolving frontiers of sleep deprivation research in the post-COVID-19 era.
  61. Research theme mapping and future directions on corruption and religion: a bibliometric analysis.
  62. Current perspectives and trends of neutrophil extracellular traps in organ fibrosis: a bibliometric and visualization study.
  63. Measuring productivity in the healthcare sector: a bibliometric and content analysis.
  64. Virtual simulation in nursing education in Latin America and the Caribbean: A bibliometric study.
  65. Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.
  66. Mapping the Global Research Landscape: A Bibliometric Analysis of Clinical Trials on Skin Aging-Trends, Innovations, and Research Gaps.
  67. Application and development of sludge-based materials for environmental pollution remediation: a bibliometric review from 2004 to 2024.
  68. The worldview of Akkermansia muciniphila, a bibliometric analysis.
  69. [Benchmarking China's Top-Tier Medical Institutions Against Global Standards: A Quantitative Analysis of the Gap Using Internationally Recognized Metrics].
  70. A bibliometric analysis of artificial intelligence research in critical illness: a quantitative approach and visualization study.
  71. Commentary on "The recent two decades of traumatic brain injury: a bibliometric analysis and systematic review".
  72. African Research Output Within the Top 5 Vascular Surgery Journals.
  73. The top 100 papers on prostate cancer-associated exosomes on social media: an altmetric study from the MENA region.
  74. Bibliometric-based visualization analysis of hotspots and trends in falls research among older hospitalized patients (2013-2023).
  75. Cancer publications using real-world data from the Taiwan National Health Insurance Research Database: conceptual framework and bibliometric analysis.
  76. Arquivos de Neuro-Psiquiatria, 80 years: part 1 (1943-1962).
  77. International medical graduate orthopaedic residents show higher research productivity than United States graduate peers before and during residency.
  78. Disclosure of Industry Relationships by Otolaryngologists.
  79. Corrigendum to "Emerging insights into traditional Chinese medicine associated with neurodegenerative diseases: A bibliometric analysis" [J. Ethnopharmacol. 337 (2025) 118785].
  80. Worldwide research tendency and collaborations on models of necrotizing enterocolitis: bibliometric exploration over the past three decades.
  81. Association Between Experienced Mentorship and Successful Publication of PGY1 Resident Research at an Academic Medical Center.
  82. Gender and Geographical Diversity in Authorship, Peer Reviewing, and Editorial Roles in the European Journal of Vascular and Endovascular Surgery Vascular Forum.
  83. Research in veterinary sciences in Kazakhstan (2018-2023): developments, gaps and opportunities.
  84. Enhancing bibliometric analysis accuracy in robotic surgery: a proposal for search strategy refinement.
  85. Anais Brasileiros de Dermatologia: who wrote this century-old history?
  86. The landscape of personality psychology in the new millennium: A systematic keyword analysis of journal articles from 2000 to 2021.
  87. Visualization analysis of CBL application in Chinese and international medical education based on big data mining.
  88. Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades.
  89. Evaluation of Imaging Research Adherence to the STARD 2015 Reporting Guideline: Update 9 Years After Implementation and Baseline Assessment.
  90. Gender composition of spasticity-related clinical practice guideline authorship positions.
  91. From virtual to reality: innovative practices of digital twins in tumor therapy.
  92. Anti-inflammatory effects of immunotherapy in clinical treatment and its potential mechanism in alleviating sleeping disorders: A systematic bibliometric study.
  93. Bibliometrics effects of a new paper level classification.
  94. Exploring women representation in major surgical society annual meetings in Italy.
  95. Quantifying Public Engagement With Science and Malinformation on COVID-19 Vaccines: Cross-Sectional Study.
  96. Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies.
  97. Frontiers and emerging topics in a century of Silkie chicken research: insights, challenges, and opportunities.
  98. Assessing the impact of micro and nanoplastics on the productivity of vegetable crops in terrestrial horticulture: a comprehensive review.
  99. Who knows what a mask is … and what it does? A bibliometric and textometric study of more than a century of scientific publications on sanitary masks (1892-2023).
  1. Digit Health. 2025 Jan-Dec;11:11 20552076251326217
    The global research of artificial intelligence on inflammatory bowel disease: A bibliometric analysis.
    Suqi Zeng, Chenyu Dong, Chuan Liu, Junhai Zhen, Yu Pu, Jiaming Hu, Weiguo Dong.
       Aims: This study aimed to evaluate the related research on artificial intelligence (AI) in inflammatory bowel disease (IBD) through bibliometrics analysis and identified the research basis, current hotspots, and future development.
    Methods: The related literature was acquired from the Web of Science Core Collection (WoSCC) on 31 December 2024. Co-occurrence and cooperation relationship analysis of (cited) authors, institutions, countries, cited journals, references, and keywords in the literature were carried out through CiteSpace 6.1.R6 software and the Online Analysis platform of Literature Metrology. Meanwhile, relevant knowledge maps were drawn, and keywords clustering analysis was performed.
    Results: According to WoSCC, 1919 authors, 790 research institutions, 184 journals, and 49 countries/regions published 176 AI-related papers in IBD during 1999-2024. The number of papers published has increased significantly since 2019, reaching a maximum by 2023. The United States had the highest number of publications and the closest collaboration with other countries. The clustering analysis showed that the earliest studies focused on "psychometric value" and then moved to "deep learning model," "intestinal ultrasound," and "new diagnostic strategies."
    Conclusion: This study is the first bibliometric analysis to summarize the current status and to visually reveal the development trends and future research hotspots of the application of AI in IBD. The application of AI in IBD is still in its infancy, and the focus of this field will shift to improving the efficiency of diagnosis and treatment through deep learning techniques, big data-based treatment, and prognosis prediction.
    Keywords:  Bibliometrics; CiteSpace; VOSviewer; artificial intelligence; inflammatory bowel disease
    DOI:  https://doi.org/10.1177/20552076251326217
  2. Int J Med Sci. 2025 ;22(7): 1585-1601
    Knowledge Landscape and Hotspots of Research in Transthyretin Amyloid Cardiomyopathy: A Bibliometric Analysis.
    Yanzhi Liu, Xinqing Li, Anran Xin, Yuhui Zhang, Jian Zhang.
      Background: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive and frequently underdiagnosed cause of heart failure characterized by the pathological deposition of misfolded transthyretin (TTR) proteins in the cardiac tissue, leading to a poor prognosis and a significant reduction in quality of life. Despite its severity, therapeutic options remain limited, and knowledge gaps persist. This study aims to construct a knowledge map and identify research hotspots within the field of ATTR-CM. Methods: Data were extracted from the Web of Science Core Collection (WoSCC), covering the period from January 1, 2000 to June 1, 2024. Bibliometric analyses were supplemented by qualitative assessments. VOSviewer, CiteSpace, and Bibliometrix were used to visualize academic community clusters, collaboration and citation networks to identify trends and hotspots in ATTR-CM research. Results: A total of 1855 publications were analyzed. Contributions from multiple disciplines fueled a consistent upward trend in publications and citations. Europe and the United States dominated ATTR-CM research, with Mathew S. Maurer as the most prolific author, and the University of London as the leading research institution. The journals publishing these documents and references demonstrated credibility and broad disciplinary coverage. Reference analysis identified 10 main research fields. Keyword analysis unveiled five promising themes for research: early diagnosis and prognosis algorithm, specific medication development, management of comorbidities and complications, epidemiology and genotype-phenotype correlation, and molecular biology and mechanisms. Conclusion: This study is the first comprehensive bibliometric analysis of the ATTR-CM field, supplemented by qualitative assessments. It systematically examines development trends, academic networks, and research themes, while identifying research hotspots and proposing future directions and approaches. These findings provide valuable insights to deepen the understanding of ATTR-CM and may foster advancements in scientific research and clinical applications.
    Keywords:  bibliometric analysis; heart failure; molecular therapeutics; tafamidis; transthyretin amyloid cardiomyopathy
    DOI:  https://doi.org/10.7150/ijms.101888
  3. Int J Oral Maxillofac Implants. 2025 Mar 17. 0(0): 1-27
    Immediate Implant and Loading Approaches: Analysis from a Bibliometric Perspective.
    Seval Ceylan Şen, Özlem Saraç Atagün, Şeyma Çardakci Bahar, Gülbahar Ustaoğlu.
       OBJECTIVE: This study aims to analyze the use of immediate implant and loading techniques in dentistry through bibliometric methods, evaluate the publication and citation trends in this field, and identify the most influential studies.
    METHODS: The WoS Core Collection database was used as the bibliographic source, and a search strategy was applied to identify relevant research articles. Bibliometric assessments were conducted using Bibliometrix software. These analyses determined the collaboration networks of authors, keywords, and publications, and research trends were identified using co-occurrence and co-citation analyses.
    RESULTS: The total number of publications peaked between 2010 and 2015. Citation numbers followed a similar trend, peaking in 2008 and becoming more prominent after 2020. Journals such as "International Journal of Oral Maxillofacial Implants", and "Clinical Oral Implants Research" are leading in the field of dental implantology, and authors like Esposito M., Covani U., and Piattelli A. are among the most productive in the field. The United States and Italy are among the leading countries in research in this area. Co Occurrence Network Analyses, Term Co-Occurrence Map Analysis, and Co-citation Analysis Network have revealed the study and application trends, topics in implantology research, and the dynamics of this scientific field.
    CONCLUSION: This bibliometric analysis demonstrates that studies on immediate implants and loading techniques represent a broad and continually evolving scientific field, offering potential collaborations and research directions for future researchers.
    Keywords:  Bibliometric analysis; Citation analysis; Co-occurrence analysis.; Dental implant; Immediate implant; Immediate loading
    DOI:  https://doi.org/10.11607/jomi.11325
  4. Int J Oral Maxillofac Implants. 2025 Mar 17. 0(0): 1-25
    From Data to Discovery: A Comprehensive Bibliometric Research on Bone Grafting in Oral Implantology.
    Liying Lin, Dongyan Zhang.
       BACKGROUND: The investigation of implant osseointegration is crucial for ensuring the long- term stability of implants. Employing bibliometric analysis allows for a comprehensive understanding of the current research landscape and emerging trends in this domain, thereby informing future research directions.
    METHODS: Utilizing the Web of Science database, we conducted a comprehensive search for articles pertaining to oral implant bone grafting published between January 1, 2014, and November 20, 2024. Our analysis encompassed several bibliometric parameters, including the number of publications, publication year, journal, impact factor, title, author, institution, keywords, and citation count. We employed VOSviewer to perform keyword co-occurrence network analysis and co-citation network analysis, and CiteSpace was utilized for national collaboration analysis and coupled clustering. Additionally, we leveraged online platforms for further visualizations.
    RESULTS: A comprehensive search yielded 384 articles published across 143 journals, authored by 2,066 individuals affiliated with 714 institutions spanning 52 countries, and encompassing 1,886 distinct keywords. The journals "Clinical Oral Implants Research" and "International Journal of Oral & Maxillofacial Implants" exhibited the highest publication volumes. Seoul Natonal University emerged as the most prolific institution in this doain. China was identified as the leading country in terms of publication output, while the United States demonstrated the highest level of international collaboration. The term "osseointegration" was the most frequently occurring keyword.
    CONCLUSION: This study presents a quantitative and statistical analysis of literature pertaining to oral implant bone grafting over the past decade. The findings offer valuable insights into the key areas of interest and the latest advancements in the clinical application of this field.
    Keywords:  Bibliometrics; Bone graft; CiteSpace; Oral implant; Osseointegration; VOSviewer
    DOI:  https://doi.org/10.11607/jomi.11283
  5. Perioper Med (Lond). 2025 Mar 17. 14(1): 31
    The global trend of intravenous anesthesia and tumors: a bibliometric and visualized study.
    Fangfang Han, Shi Dong, Zhou Chen, Cheng Ye, Chunlu Dong, Yan Du, Huaqing Shi, Gen Lu, Wence Zhou.
       BACKGROUND: Through bibliometric analysis, this paper summarizes the growing literature and analyses the development trends and hot spots in the research field of the association between intravenous anesthesia and tumors.
    METHODS: A literature overview was conducted using relevant articles retrieved from the Web of Science Core Collection published between 1991 and 2024. Bibliometric websites and tools (VOSviewer, CiteSpace, and bibliometric R package) are used to analyze the co-occurrence of keywords and reference citations, detailing countries, institutions, authors, references, journals, and keywords.
    RESULTS: A total of 1198 relevant articles were included in the study. The USA, China, and Germany have the largest number of publications, with the USA and China having the most interagency cooperation and Germany relatively less cooperation. The institution that publishes the most articles is the University of National Defense Medical Center, and the journal that publishes the most articles is Anesthesiology. The five most productive authors are Li J., Liu J., Zhang B., Yu X.J., and Xu J. "Surgery", "anaesthesia", and "propofol" are the most common keywords. In recent years, research has focused mainly on intravenous anesthesia and tumor survival.
    CONCLUSION: Both Western countries and China have made outstanding contributions to intravenous anesthesia and tumors. In recent years, the number of publications in China has steadily increased, and the quality and influence of these articles deserve recognition. Future research should focus on the key areas of intravenous anesthesia, tumor recurrence, and survival.
    Keywords:  Bibliometric analysis; CiteSpace; Intravenous anesthesia; Tumor; VOSviewer
    DOI:  https://doi.org/10.1186/s13741-025-00513-z
  6. Cureus. 2025 Feb;17(2): e79038
    Enhanced Recovery After Surgery Pathways and Obstetric Anesthesia: A Bibliometric Analysis.
    Abhijit Nair, Ujjwalraj I Dudhedia.
      As enhanced recovery after surgery (ERAS) pathways are being used exceedingly all over the world, research on ERAS and obstetric anesthesia is expanding. The necessity for uniform guidelines is highlighted by the notable regional and institutional differences in ERAS pathway implementation. Bibliometric research can identify these differences, which promotes a more consistent use of evidence-based procedures. The present bibliographic analysis reviewed 866 documents from the Scopus database using the keywords "enhanced recovery after surgery, ERAS, and Obstetrics Anesthesia." An increased number of articles were added to the database from 2017, with 175 articles in 2024. VOSviewer software (version 1.6.20, Leiden University, Netherlands) was used to investigate the various aspects of bibliometric analysis. The five aspects that were analyzed were co-authorship, co-occurrence, citation, bibliographic coupling, and co-citation. The United States of America had the maximum number of articles, citations, organizations, co-authorship, and co-citation with other authors, organizations, and countries. In the citations category, Gustafsson had the maximum number of citations in documents, and Anesthesia and Analgesia had the maximum number of citations in a journal. A thorough summary of the development of the field of ERAS in obstetric anesthesia can be found in this bibliometric analysis. This analysis has identified important research contributions, significant authors, and new trends by looking at publications, citations, and collaborations. Future research, policymaking, and clinical practice could benefit greatly from this information.
    Keywords:  anesthesia; bibliometric analyis; enhanced recovery after surgery (eras) protocols; obstetric anesthesia; vos-viewer
    DOI:  https://doi.org/10.7759/cureus.79038
  7. Medicine (Baltimore). 2025 Mar 14. 104(11): e41803
    Epidural hematoma: Bibliometric analysis of scientific trends and developments from 1980 to 2023.
    Hakan Kina, Murat Kiraz.
      The aim of this study is to identify research directions focused on epidural hematoma (EDHs) from past to present using bibliometric approaches, uncover current research trends through keyword analyses, delineate global productivity, and identify impactful studies through citation analyses. The study obtained 1785 articles related to EDH published between January 1, 1980, and December 31, 2023, from the Web of Science database, and comprehensive analyses were conducted using various bibliometric and statistical approaches. These analyses include citation and co-citation analyses, trend keyword analysis, multiple correspondence analysis, thematic evolution analysis, and various other bibliometric analyses. The bibliometric analyses were performed using Biblioshiny and VOSviewer. The top 3 journals contributing the most to the literature were Acta Neurochirurgica (n = 56, 3.1%), British Journal of Neurosurgery (48, 2.6%), and Neurosurgery (47, 2.6%). According to the h-index, the most influential top 3 journals were Neurosurgery (h = 27), Acta Neurochirurgica (h = 23), and Surgical Neurology (h = 21). Based on the m-index, the most influential top 3 journals were World Neurosurgery (m = 0.9), Medicine (m = 0.63), and Neurosurgery (m = 0.6). The most active country was the United States of America (n = 593), the most active author was Mahapatra AK (n = 10), and the most active institution was Harvard University (n = 25). Research interest in EDH has evolved over time, with notable increases in publication trends in 1968, 1982, and 1988, peaking in 1996 and 2004. Bibliometric analyses indicate that key topics such as spinal EDH, head injuries, magnetic resonance imaging, spontaneous spinal EDH, computed tomography, spine, complications, epidural, anticoagulants, pediatric cases, and trauma have stood out in EDH research. Trend analysis findings have shown an increasing focus on specific areas such as clinical management approaches, treatment methods, postoperative complications, risk factors, pediatric cases, as well as specific conditions like paralysis and cauda equina syndrome. Multiple correspondence analysis identified 6 core research dimensions, focusing on acute trauma management, surgical interventions, complications management, risk assessment, surgical outcomes, and incidence analysis.
    DOI:  https://doi.org/10.1097/MD.0000000000041803
  8. Medicine (Baltimore). 2025 Mar 14. 104(11): e41835
    A visualization analysis of global research trends in targeted therapies for thyroid carcinoma (2013-2023).
    Yu Mao, Fei Ye, Qin Jiang, Sushun Liu, Yi Gong.
      This study aims to analyze and identify primary research trends in targeted therapy for thyroid carcinoma (TC). It seeks to provide a factual foundation for researchers, as TC often presents with advanced stages and aggressive subtypes, leading to unfavorable clinical outcomes. The evolution of targeted therapies introduces promising treatment possibilities, necessitating a bibliometric analysis to better understand the current state and trends in this field. A comprehensive bibliometric analysis was conducted using data from the Web of Science Core Collection (WOSCC). Advanced search queries established a literature database, and the analysis was performed using tools such as VOSviewer, CiteSpace, Tableau, and Microsoft Excel. The study focused on publications from 2013 to 2023, examining patterns, geographical contributions, institutional output, and influential journals. The analysis identified 763 publications on TC targeted therapy during the study period, with significant contributions from the United States, China, and Italy, and the United States leading in output. Research activity peaked in 2021, showing overall fluctuating growth. Key contributing institutions included the University of Texas MD Anderson Cancer Center and the University of Pisa. Notable journals, such as Cancers and Thyroid, were among the most cited, underscoring their impact in the field. The study highlighted an increase in global research output and robust international collaborations, particularly among the leading contributing countries. This bibliometric analysis provides a comprehensive overview of significant contributions and trends in targeted therapy research for TC. It identifies key development processes and research hotspots, offering valuable insights to guide future research directions. The findings aim to stimulate further studies and foster advancements in this critical area of oncology.
    DOI:  https://doi.org/10.1097/MD.0000000000041835
  9. Front Endocrinol (Lausanne). 2025 ;16 1546554
    Knowledge mapping of exosomes in preeclampsia: a bibliometric analysis (2008-2023).
    Liang Yin, Yuchao Zhang, Guanfeng Fu, Haiqin Huang, Hang Su, Yipeng Zhang, Qichun Chen, Qinghua Li, Weiwei Yang.
       Background: Exosome research in preeclampsia is gaining increasingly popular, however thorough and unbiased summaries of the field's present understanding are hard to come by. Therefore, this study aims to conduct a bibliometric analysis of the publication "Exosomes in Preeclampsia" in order to visually analyze the state of the field and identify emerging trends.
    Methods: From 2008 to 2023, the Web of Science database was searched for publications related to exosomes in preeclampsia. Three software packages-VOSviewer, CiteSpace, and the R program "bibliometrix"-were used to conduct bibliometric analysis.
    Results: Analysis of 257 publications produced by 1454 scholars from 48 countries/regions and 435 institutions, published in 135 academic journals. The quantity of studies concerning exosomes in preeclampsia is steadily increasing. China and the United States lead in publications, with Oxford being the most active university. Placent has written the most relevant study and has received the highest number of citations. Carlos Salomon has the most number of published articles and is the most referenced author. The 10 most frequently mentioned sources were used as a knowledge basis. The predominant terms examined include extracellular vesicle, expression, pregnancy, microparticle, and microRNA. Utilizing fundamental research on exosomes in preeclampsia for clinical diagnosis and therapy is a current popular research focus and direction. Utilizing fundamental research on exosomes in preeclampsia for clinical diagnosis and treatment is currently a popular research focus and direction.
    Conclusion: This study offers a comprehensive overview of trends and advancements in the research of exosomes in preeclampsia through bibliometrics. This material highlights the current research frontiers and trending directions, serving as a valuable reference for researchers in the subject.
    Keywords:  CiteSpace; VOSviewer; bibliometric; bibliometrix; exosome; knowledge-map; preeclampsia
    DOI:  https://doi.org/10.3389/fendo.2025.1546554
  10. Front Oncol. 2025 ;15 1489043
    Gastric cancer peritoneal metastasis: a bibliometric study from 2000 to 2024 using VOSviewer software.
    Manting Y, Dongfang L.
       Background: Gastric cancer remains a prevalent malignancy worldwide, with peritoneal metastasis being the predominant form of recurrence and metastasis, which are clear predictors of prognosis. The aim of this comprehensive bibliometric analysis was to assess the current status of the research landscape and to identify impending trends in gastric cancer peritoneal metastasis (GCPM).
    Methods: Relevant studies of GCPM were retrieved from the Web of Science Core Collection database. Qualified articles were screened based on the inclusion and exclusion criteria for further analysis. The selected publications were then subjected to bibliometric analysis utilizing VOSviewer software.
    Results: In total, 1,100 publications were included for analysis. The results revealed a consistent upward trend in the number of publications annually from 2000 to 2024, with an anticipated continuation of this growth in future research. The National Cancer Center Japan, emerged as the institution with the most publications and Professor Kodera and Annals of Surgical Oncology were identified as the most influential author and journal, respectively, in the domain of GCPM. In terms of international collaborations, the USA, Japan, and France were the most engaged countries. Yonemura was recognized as the most frequently cited author. Gastrectomy, systemic chemotherapy, and intraperitoneal therapy are the current research hotspots within this domain.
    Conclusion: Research related to GCPM had rapidly increased over the past two decades. These findings identify the most influential countries, institutions, authors, journals, and academic collaboration networks, while also clarifying hotspots and future trends in GCPM research.
    Keywords:  VOSveiwer; bibliometric analysis; gastric cancer; knowledge-map; peritoneal metastasis
    DOI:  https://doi.org/10.3389/fonc.2025.1489043
  11. Curr Pain Headache Rep. 2025 Mar 19. 29(1): 65
    Trends in Mixed Pain Research Over Three Decades (1993-2024): A Bibliometric Analysis.
    Matteo Luigi Giuseppe Leoni, Marco Mercieri, Roberto Gazzeri, Marco Cascella, Martina Rekatsina, Omar Viswanath, Alberto Pasqualucci, Giustino Varrassi.
       BACKGROUND: The term "mixed pain" is frequently used in clinical practice to describe the coexistence of nociceptive, neuropathic, and nociplastic pain mechanisms. However, its inconsistent use and lack of a formal definition warrant further investigation. This bibliometric analysis aims to explore publication trends, research networks, and key themes in mixed pain literature.
    METHODS: A bibliometric analysis was conducted using the Web of Science Core Collection. The search was performed in February 2024, with journal rankings obtained from Journal Citation Reports™ 2022 (Clarivate Analytics). Extracted data included publication trends, citation analysis, co-authorship networks, and keyword mapping.
    RESULTS: A total of 229 publications were identified, demonstrating an increasing trend in both publication volume and citations. Most studies were published in high-ranking Q1 journals as research (77%) and review articles (19%). The USA (21%), Italy (15%), and Germany (12%) were the leading contributors, yet global collaboration was weak, with limited co-authorship connections except within the USA. The keyword analysis revealed five major research clusters, with "neuropathic pain," "management," and "quality of life" emerging as central themes.
    CONCLUSIONS: Despite the progressive increase in mixed pain articles in highly ranked journals, this bibliometric analysis highlighted the absence of a well-structured collaborative network among authors and a lack of clear connections between keywords. Given the critical clinical implications of mixed pain, further high-quality studies on this topic and enhanced international collaborations are recommended.
    Keywords:  Bibliometric analysis; Mixed pain; Multidisciplinary approach; Neuropathic pain; Nociceptive pain; Nociplastic pain; Pain management; Quality of life
    DOI:  https://doi.org/10.1007/s11916-025-01371-6
  12. Curr Neuropharmacol. 2025 Mar 18.
    Research Trends and Evolution of Astrocytes in Depression and Antidepressant Treatment: A Bibliometric Analysis.
    Shu-Man Pan, Zhe Li, Jing-Qi Zhou, Xiang Shang, Tian-Jia Gu, Xiao-Ming Sun, Zhen-Hua Zhu.
       BACKGROUND: Astrocytes have emerged as key players in the pathogenesis of depression and antidepressant treatment. However, comprehensive reviews in this field were absent. The bibliometric analysis can effectively illustrate research trends and hotspots of a specific domain through analysis of publications.
    OBJECTIVE: We conducted a bibliometric analysis to overview the current hotspots and research trends of astrocytes in depression and antidepressant treatment.
    METHODS: We collected publications' data from the science citation index expanded (SCI-E) of the Web of Science (WOS) database, and bibliometric analysis was applied through CiteSpace and VOSviewer software. Results were mapped via GraphPad Prism, Adobe Photoshop, and R software.
    RESULTS: After analysis of 2896 publications, we analyzed the content of publications, most influential publications, productive journals, most cited journals, core authors, productive countries/regions, and institutions in this field. The cooperation of main countries and organizations was mapped. Most importantly, after a thorough analysis of keywords, we found neuroinflammation is a hot topic in this research field.
    CONCLUSIONS: The results of the bibliometric study prove neuroinflammation is a hot topic in this research field. Nowadays, many studies have investigated the role of astrocytes in depression and antidepressant treatment from the perspective of neuroinflammation. It is essential to pay more attention to elucidating the mechanisms of astrocyte-mediated neuroinflammation to identify potential targets for antidepressant development.
    Keywords:  Astrocyte; VOSviewer; antidepressant treatment; bibliometric analysis; depression; neuroinflammation.
    DOI:  https://doi.org/10.2174/011570159X353752250227113751
  13. Curr Pharm Biotechnol. 2025 Mar 19.
    Tumor Image Segmentation: A Bibliometric Analysis from 2003 to Now.
    Zhenghao Chen, Zhongqing Wang, He Ma.
       BACKGROUND: Bibliometrics has been applied to the study of tumor image segmentation, which can indicate the current research hotspots and trends.
    METHOD: In this study, bibliometric analyses were performed on data retrieved from the Web of Science database. A total of 3377 articles on the application of tumor image segmentation from January 1, 2003, to October 9, 2024, were analyzed for the characteristics of the articles, including the number of yearly publications, country/region, institution, journal, author, keywords, and references. Visualising co-authorship, co-citation, and co-occurrence analysis with VOSviewer.
    RESULTS: The annual publication volume of tumor image segmentation literature shows that from the first time of more than 100 articles in 2016, the publication volume of literature in this field has surged, reaching 576 articles by 2023. Mainland China is ranked first in terms of publication volume (n=1356). Saudi Arabia ranks first in average publication year (n=2021.96). IEEE Transactions on Medical Imaging was the journal with the highest average number of citations. The Chinese Academy of Sciences (n=78) was the most prolific institution, while Harvard University was the most prestigious, with a total number of citations and an average number of citations of 3190 and 213, respectively. In terms of keywords, co-occurrence analysis of 107 keywords with a frequency of more than 30 times produced four clusters: (1) methods of image segmentation, (2) applications of image segmentation, (3) image segmentation modelled on CT, (4) image segmentation modelled on MRI. Transformer, Attention Mechanism, and U-Net are the latest keywords. The analysis of keywords helps scholars understand and identify the current research hotspots and research directions.
    CONCLUSION: Within the last 20 years, the number of articles on the application of tumor image segmentation has increased steadily. From U-Net to MAMBA, many methods for tumor image segmentation have been proposed, and the limitations of models and algorithms are becoming increasingly smaller, which demonstrates the importance of advances in tumor image segmentation technology for disease prevention and monitoring. It presents a strong connection between countries/regions and authors, which reflects the global interest and support for the development of this field. This study shows global trends, research hotspots, and emerging topics in this field and reviews some of the knowledge about tumor image segmentation applications from past studies. And it will provide good research guidelines for researchers in this field.
    Keywords:  Bibliometrics; MAMBA.; Tumor Image; U-Net; VOSviewer
    DOI:  https://doi.org/10.2174/0113892010325620250312082433
  14. J Clin Orthop Trauma. 2025 May;64 102952
    Bibliometric studies: Essential navigational tools in today's academic landscape.
    Raju Vaishya, Brij Mohan Gupta.
      
    Keywords:  Academic collaboration; Bibliometric analysis; Citation patterns; Research metrics; Scholarly communication
    DOI:  https://doi.org/10.1016/j.jcot.2025.102952
  15. Front Neurosci. 2025 ;19 1506566
    Bibliometric analysis of the intestinal microbiota and demyelinating diseases, particularly multiple sclerosis, since 2014.
    Ling Chen, Le-Le Wu, Chang-Yin Yu, Zu-Cai Xu, Hao Huang.
       Background: The gut-brain axis (GBA) represents a complex, bidirectional communication network that connects the central nervous system (CNS) and the gastrointestinal system. Our study aimed to explore the correlation between the intestinal microbiota and demyelinating diseases from a bibliometric perspective, focusing on research since 2014.
    Methods: A comprehensive search was carried out on the Web of Science Core Collection (WoSCC) to locate studies on the intestinal microbiota and demyelinating diseases, with a focus on publications from 1 January 2014 to 29 March 2024. We visualized and analyzed the data using VOSviewer, CiteSpace, and Charticulator.
    Results: We gathered 429 scholarly articles on the intestinal microbiota and demyelinating disorders published in the past 10 years. Research concerning the intestinal microbiota and demyelinating diseases has demonstrated a consistent increase in frequency over time. The USA has the highest number of publications, while Canada has the highest average number of citations, reaching as high as 3,429, which is greater than that of the USA. Moreover, the journal with the highest number of publications was Frontiers in Immunology, with 33 publications and 1,494 citations. The majority of the scholars focused on "multiple sclerosis" and "gut microbiota," which are the primary keywords in the field of the intestinal microbiota and demyelinating diseases.
    Conclusion: This study conducted a comprehensive analysis of existing research investigating the correlation between the intestinal microbiota and demyelinating diseases. Using advanced bibliometric tools such as VOSviewer and CiteSpace, this study analyzed the intricate relationship between the intestinal microbiota and the pathogenesis of demyelinating conditions. In addition, the study used literature statistical analysis to identify research hotspots and future directions in the field.
    Keywords:  bibliometrics; demyelinating diseases; intestinal microbiota; multiple sclerosis; visualization analysis
    DOI:  https://doi.org/10.3389/fnins.2025.1506566
  16. Front Oncol. 2025 ;15 1490108
    Global research and emerging trends in depression in lung cancer: a bibliometric and visualized study from 2014 to 2024.
    Weilan Lin, Shun Chen, Jiawei Chen, Chune Wang, Feng Lu.
       Background: The impact of depression on the physical and psychological well-being of lung cancer patients has raised significant concerns. This study explored lung cancer-related depression research from a bibliometric perspective.
    Methods: Articles and reviews on depression in lung cancer published from 2014 to 2024 in the Web of Science Core Collection were retrieved and identified. The information extracted included "Full Record and Cited References". Bibliometric analysis was conducted using CiteSpace and Excel to examine relevant publications in terms of country, institution, authorship, journal, citations, and keywords.
    Results: A total of 761 publications on depression in lung cancer were identified for analysis, contributed by 4,667 authors from 305 institutions and 58 countries. The annual publication count has steadily increased, culminating in a peak in 2024. China (275 papers), Harvard University (58 publications), and Joseph A. Greer (25 publications) were the most productive and influential country, institution, and author, respectively. Jennifer S. Temel emerges as a highly influential author, securing the second position in terms of both publication count and citation impact. The journal with the highest number of publications is Supportive care in cancer, while the Journal of Clinical Oncology has garnered the most citations. Reference and keyword analysis indicated that the research hotspots mainly included 1) Epidemiology of lung cancer-related depression; 2) The deleterious impact of depression on lung cancer patients, particularly with regards to their quality of life; 3) Association between inflammation and depression in lung cancer; 4) Treatment.
    Conclusions: Our study employed bibliometric analysis to identify prevalent focal areas and emerging trends in the field of research on lung cancer-related depression. Our study found that numerous unanswered questions persist, including the intricate relationship between lung cancer and depression, the profound impact of depression on lung cancer patients, and the interplay between inflammation and depression in this specific population. Furthermore, a current challenge in clinical practice involves the development of secure and more efficacious treatment strategies for individuals with lung cancer-related depression. These findings provide valuable guidance for scholars seeking to explore new avenues of investigation.
    Keywords:  CiteSpace; bibliometric; depression; hotspots; lung cancer; visualization
    DOI:  https://doi.org/10.3389/fonc.2025.1490108
  17. Ann Med Surg (Lond). 2025 Feb;87(2): 711-719
    The 100 most-cited papers on esthesioneuroblastoma: a bibliometric analysis.
    Amr Badary, Sura N Alrubaye, Wireko Andrew Awuah, Yasser F Almealawy, Mohammad Al-Barbarawi, Wahab Moustafa, Hira Jawed, Bipin Chaurasia, Oday Atallah.
       Objective: Esthesioneuroblastoma (ENB) or olfactory neuroblastoma, an infrequent neuroectodermal tumor primarily affecting the nasal cavity, manifests sporadically or in various clinical contexts. Bibliometric analyses have become a technique for evaluating the influence of papers in present-day clinical practice.
    Methods: This article conducted a meticulous analysis of the top 100 cited articles concerning ENB, using Scopus and employing keywords ("Esthesioneuroblastoma" and "Olfactory Neuroblastoma"). Articles focusing on ENB were systematically evaluated. Data extraction encompassed comprehensive analyses of articles, authors, citation per year, total citations, and journals, categorizing publications into distinct domains: clinical features, histopathology, article types, or radiological aspects.
    Results: The search yielded a substantial pool of 400 articles, from which the top 100 amassed a total of 10 900 citations, averaging 109 citations per article. These influential publications spanned a wide array of 47 journals, published between 1960 and 2019, involving contributions from diverse institutions across 14 countries. Notably, a significant proportion (45%) of contributions was made before the 2000, with the most prolific decade being 2000-2010, contributing 38 publications.
    Conclusion: This bibliometric study summarizes the most-cited articles on esthesioneuroblastoma, providing light on the field and its seminal works that have shaped both present-day clinical treatment and the trajectory of future research.
    Keywords:  bibliometrics; citation analysis; esthesioneuroblastoma; olfactory neuroblastoma
    DOI:  https://doi.org/10.1097/MS9.0000000000002933
  18. Ann Med Surg (Lond). 2025 Feb;87(2): 684-695
    The 100 most influential papers on Lewy body dementias: a bibliometric analysis.
    Zain Ali Nadeem, Ahmad Danial, Zoya Imran, Adeena Jamil, Butool Nusrat, Sara Jawed, Amna Siddiqui, Unsa Habib Shaikh, Aalaa Saleh, Rameen Rao.
       Introduction: Lewy body dementias (LBDs) are poorly understood neurodegenerative diseases. We aim to uncover the most cited articles and authors in the field, and to analyze the citations for gender differences.
    Methods: Two authors extracted the relevant articles from Scopus and ranked them according to the number of citations. Separate lists were prepared for the top 100 original articles and the top 15 review articles.
    Results: The 100 original studies were published from 1980 to 2019, with the greatest number published in the year 2000. The total citations ranged from 350 to 2640, with a median of 494.5. These articles originated from 17 countries, with major contributions from the USA (n = 31). While most of the first authors were men (n = 67), the citations per year were higher where the first authors when women. The last authors of the top 100 original articles were also predominantly male (n = 70). The greatest number of articles were published in neurology (n = 12) and brain (n = 11).
    Conclusion: Our results provide insights into the research trends and provide a list of the most influential papers on LBDs. Resolving the observed differences and promoting contribution from people all over the world is necessary to accelerate advancement in the field.
    Keywords:  Lewy body; Parkinson’s disease; bibliometric analysis; citation trends; dementia
    DOI:  https://doi.org/10.1097/MS9.0000000000002909
  19. J Cardiothorac Surg. 2025 Mar 20. 20(1): 155
    Global trends and research hotspots in acupuncture treatment for cardiovascular diseases over the past decade: a bibliometric study.
    Wenhui Wang, Kewen Wang, Qianlan Zeng, Jiaojiao Zhang, Haiyan Zuo, Shuai Cui, Shengbing Wu, Meiqi Zhou.
       BACKGROUND: This study aims to examine the status and emerging trends of acupuncture treatment for cardiovascular disease (CVD) over the past decade. By conducting a visual analysis of existing literature, it seeks to offer new insights for future research directions.
    METHODS: From the Web of Science Core Collection database, we retrieved papers on acupuncture treatment for CVD published between January 1, 2014, and December 31, 2023. Bibliometric analyses were conducted using VOSviewer and CiteSpace software to elucidate research progress and identify key research hotspots.
    RESULTS: We identified 346 publications related to acupuncture for CVD that were published between 2014 and 2023. We determined the most productive journals, countries, institutions, authors, author patterns, and main directions for future research in the field of acupuncture. China was the top publishing country with 267 publications; Beijing University of Chinese Medicine was the leading institution with 42 publications; and the journal Evidence-Based Complementary and Alternative Medicine was the most prolific, with 43 publications. High-frequency keywords included "blood pressure," "acupuncture," "electroacupuncture," "stimulation," and "mechanism." The top five keywords by centrality ranking were "electroacupuncture," "myocardial ischemia," "stimulation," "randomized controlled trial," and "acupuncture."
    CONCLUSION: While progress exists in bibliometric research on acupuncture treatment for CVD, more comprehensive analyses remain essential. This study provides a multidimensional overview, delineating current advancements and emerging trends, offering evidence-based insights for clinical practice and quantitative references for identifying collaborators, key institutions, and future directions.
    Keywords:  Acupuncture; Bibliometric study; Cardiovascular disease; Citespace; VOSviewer; Visual analysis
    DOI:  https://doi.org/10.1186/s13019-025-03380-3
  20. J Cardiothorac Surg. 2025 Mar 20. 20(1): 157
    Research progress and hotspot analysis of type B aortic dissection: a bibliometric analysis from 2004 to 2023.
    Zhen-Yi Zhao, Shu-Li Zhou, Yun Peng, Can Cui, Liang-Geng Gong.
      This study aimed to analyze and visualize the research on type B aortic dissection (TBAD) over the past 20 years through bibliometric research. To reveal the development process of TBAD research and the transitions of research hotspots. Literatures was retrieved from the Web of Science Core Collection. The analysis utilized tools such as Microsoft Office Excel, VOSviewer and CiteSpace for bibliometric mapping and visualization, including assessing publication volumes and constructing collaborative networks and keyword burst graphs. A total of 1391 related articles or reviews on TBAD were included. The number of annual publications is steadily increasing. China was the top country in terms of the number of publications. University of Michigan (n = 60) was the most productive university. The Journal of Vascular Surgery (n = 183) was the most published and co-cited journal. Keywords burst analysis showed that "guidelines", "spinal-cord ischemia", "society", "impact", and "aortic remodeling" were the most frequently used keywords in recent years. In general, the research focus of TBAD has gradually changed from selecting the surgical method to the best clinical management and patient prognosis after thoracic endovascular aortic repair (TEVAR). Promoting positive aortic remodeling and aortic hemodynamics may be the research hotspots in the future.
    Keywords:  Bibliometric; Hemodynamics; Spinal cord ischemia (SCI); Stent-graft placement; Thoracic endovascular aortic repair (TEVAR); Type B aortic dissection (TBAD)
    DOI:  https://doi.org/10.1186/s13019-025-03400-2
  21. J Asthma Allergy. 2025 ;18 417-435
    Hotspots and Trends in Allergic Rhinitis Nasal Mucosa Studies: A Bibliometric Analysis (2010-2024).
    Meiya Wang, Linyou Fu, Huan Wang, Li Tian.
       Purpose: This study aims to conduct a bibliometric and visual analysis of the research on the nasal mucosa in allergic rhinitis (AR) and to explore its emerging trends, hotspots, and future development.
    Methods: We comprehensively searched the Web of Science Core Collection (WoSCC) for literature related to the nasal mucosa in AR published between 2010 and 2024. Bibliometric and visual analyses were performed using CiteSpace, VOSviewer, and the R language.
    Results: A total of 1124 relevant articles were included in this study, and the analysis showed that the number of articles in this field has been increasing year by year. China dominated the article output, followed by South Korea and Japan. American Journal of Rhinology & Allergy (69 articles) topped the list of publications; keyword analysis showed that "immune response", "inflammatory response", "autophagy", "NLRP3 inflammasome", and "miRNAs" are hotspots in this field.
    Conclusion: Over the past decade, research related to the nasal mucosa in AR have gained growing interest. This study is the first to use visualization software and data mining information to conduct a bibliometric analysis in this particular field, thereby providing fresh perspectives on the research terrain.
    Keywords:  CiteSpace; NLRP3 inflammasome; autophagy; miRNAs; visualization
    DOI:  https://doi.org/10.2147/JAA.S503477
  22. Aesthet Surg J Open Forum. 2025 ;7 ojaf012
    Measuring Medical Student Scholarly Activity After a Structured Plastic Surgery Research Fellowship: A Bibliometric Analysis.
    Jasmine A Panton, Bhavana Thota, Abby J Culver, Jeffrey M Kenkel.
       Background: Plastic surgery is consistently one of the most competitive medical specialties in the National Resident Matching Program match, with students often partaking in dedicated research fellowships to bolster their applications.
    Objectives: The purpose of this study was to quantify the academic productivity of medical students completing a structured plastic surgery research fellowship at a single academic center over a 7-year period.
    Methods: The bibliometric output of 26 medical student research fellows was analyzed. Eligible scholarly activities for analysis included peer-reviewed articles, books and book chapters, and video editorials published in the field of plastic surgery and indexed between July 1 of the fellowship and September 1, 2023. Cross-verified citation lists were generated for each author and h-index, publication number, number of citing articles, sum of times cited, author position, and journal or book title were recorded.
    Results: Twenty-four of 26 research fellows have published a total of 177 scholarly activities (93.22% articles) which have been cited in ∼322 articles. The mean publication per fellow is 6.69 and the mean h-index is 1.46. Analysis excluding the 2022-2023 cohort revealed a strong positive correlation between years since beginning research fellowship and both mean h-index (r = 0.84, P < .001) and mean number of publications per year (r = 0.81, P < .001).
    Conclusions: Structured research fellowships can serve as a springboard for medical students to increase research output and engage meaningfully with academia. The authors of this study suggest that publications in peer-reviewed journals continue to increase following participation in a structured plastic surgery research fellowship.
    Level of Evidence 4 Therapeutic:
    DOI:  https://doi.org/10.1093/asjof/ojaf012
  23. J Perianesth Nurs. 2025 Mar 20. pii: S1089-9472(24)00565-3. [Epub ahead of print]
    Mapping the Nursing Literature on Postoperative Delirium: A Bibliometric Analysis.
    Melis Merve Cetinkaya, Seçil Taylan, Fatma Eti Aslan.
       PURPOSE: To provide a structured, macroscopic overview of nursing research on postoperative delirium through bibliometric analysis, assessing its characteristics and progress.
    DESIGN: Bibliometric analysis study.
    METHODS: For the bibliometric analysis study, the Web of Science database was selected, and the data analyzed was included until August 28, 2024. The analysis was performed using the "Biblioshiny" application available in the Bibliometrix R package.
    FINDINGS: Between 1977 and 2024, 535 nursing articles on postoperative delirium were published in 313 sources. When examining the annual scientific output of nursing studies on postoperative delirium, the most prolific journals were found to be Journal of Clinical Nursing (n = 18), Journal of Perianesthesia Nursing (n = 13), and Journal of the American Geriatrics Society (n = 13). According to Bradford's law-based analyses, there are 313 productive journals in the nursing literature on postoperative delirium. These journals are distributed as follows: 29 in the first zone, 108 in the second zone, and 176 in the third zone. Authors and articles were organized according to Lotka's law. The majority (88.9%) of the authors (n = 2,486) had 1 article, 8.7% had 2 articles (n = 243), and 1.5% had 3 articles (n = 43), while 0.2% (n = 7) had more than 5 publications. Recent trends show a shift toward research on recovery, guidelines, and 3 outcomes, with studies on experience, impact, and cardiac surgery. The countries with the highest number of publications were identified as the United States, Germany, and China. Global collaborations on this topic were: United States-Canada (n = 8), United States-Germany (n = 7), United States -United Kingdom (n = 7).
    CONCLUSIONS: This bibliometric study provides a comprehensive and integrative review of the global literature on postoperative delirium in nursing.
    Keywords:  bibliometric analysis; delirium; nursing; surgery
    DOI:  https://doi.org/10.1016/j.jopan.2024.12.003
  24. World J Gastrointest Oncol. 2025 Mar 15. 17(3): 102111
    Advances and global trends of precancerous lesions of gastric cancer: A bibliometric analysis.
    Yuan-Ping Jia, Dian-Chun Liu, Ting-Lan Cao, Hui-Zhong Jiang, Tao Li, Yuan Li, Xia Ding.
       BACKGROUND: Precancerous lesions of gastric cancer (PLGC) represent a critical pathological stage in the development of intestinal gastric cancer. Early detection and diagnosis are key to reducing the incidence of gastric cancer. Substantial advancements have been made in PLGC research in recent years, making it necessary to provide updated reviews using bibliometric methods. We hypothesize that this review will identify emerging trends, key research areas, and gaps in PLGC research, providing insights that could guide future studies and enhance prevention strategies.
    AIM: To comprehensively review the current state of research on PLGC, examining development trends and research hotspots.
    METHODS: We conducted a bibliometric analysis of PLGC-related studies published between 2004 and 2023 using the Web of Science Core Collection database. We employed Software, including VOSviewer, CiteSpace, R software, and SCImago Graphica, to map scientific networks and visualize knowledge trends in terms of publication volume, countries/regions, institutions, journals, authors, and keywords.
    RESULTS: A total of 4097 articles were included, and overall publication volume showed an increasing trend. Over the past two decades, China published the most articles, followed by the United States, Japan, South Korea, and Italy. Among the top 10 contributors, the United States ranked highest in institutions, authors, and citations and demonstrated the strongest international collaboration. Research keywords in this field were clustered into three main categories: Risk factors, pathogenesis, and diagnosis and treatment. Pathogenesis and molecular biomarkers remain key areas of focus. Future research should explore the mechanisms of gut microbiota, immune microenvironment, metabolic reprogramming, and epigenetics. Advanced technologies, including single-cell sequencing, spatially resolved analysis, multi-omics approaches, artificial intelligence, and machine learning, will likely accelerate in-depth investigations of PLGC.
    CONCLUSION: PLGC research has rapidly developed in recent years, gaining considerable attention. This bibliometric analysis reveals research state and emerging trends over the past 20 years, providing insights for future studies.
    Keywords:  Bibliometric; Dysplasia; Gastric precancerous lesion; Precancerous lesions of gastric cancer; Visualization
    DOI:  https://doi.org/10.4251/wjgo.v17.i3.102111
  25. Ren Fail. 2025 Dec;47(1): 2477302
    Knowledge mapping and visualized analysis of research progress in onconephrology: a bibliometric analysis.
    Yiwei Wang, Shuling Fan, Wei Wang.
       OBJECTIVES: Onconephrology is an expanding subspecialty focused on the management of cancer patients with renal injury. This study used a comprehensive bibliometric analysis to emphasize the need for cooperation between oncologists and nephrologists, exploring current trends and future research areas in onconephrology.
    METHODS: Relevant literature on onconephrology published between 1 January 2000 and 27 April 2024 was retrieved from the Science Citation Index Expanded of the Web of Science Core Collection, followed by manual screening. Bibliometric analyses were performed using CiteSpace, VOSviewer, and Bibliometrix software.
    RESULTS: A total of 1,853 publications, including 1,647 articles and 206 reviews, by 11,606 authors from 2,757 institutions in 73 countries, were analyzed. Annual publications generally follow a steadily increasing trend, ranging from 25 to 161 documents. The United States (n = 464), The University of Texas MD Anderson Cancer Center (n = 39), Meletios A. Dimopoulos (n = 21), and Nephrology Dialysis Transplantation (n = 35) were the most productive country, institution, author, and journal, respectively. Immune checkpoint inhibitors, glomerular filtration rate, and cisplatin were clusters of highly cited references after 2015. Oxaliplatin, calcium, open-label, and thrombotic microangiopathy were trending topics after 2020. Outcome, acute kidney injury, immunotherapy, and chronic kidney disease were keyword bursts that persisted through 2024.
    CONCLUSION: Current research of onconephrology is focusing on chemotherapeutic nephrotoxicity, kidney function assessment, dosing of chemotherapeutic agents in chronic kidney disease, glomerular disease in cancer, immunotherapy, and electrolyte disturbances. Future directions in this field include clinical trials and thrombotic microangiopathy.
    Keywords:  Acute kidney injury; bibliometrics; chronic kidney disease; immunotherapy; onconephrology
    DOI:  https://doi.org/10.1080/0886022X.2025.2477302
  26. Discov Oncol. 2025 Mar 21. 16(1): 371
    Progress in ubiquitination and hepatocellular carcinoma: a bibliometric analysis.
    Ming Li, Zhiliang Xu, Siqin Liang, Qiaoli Lv, Xiaoxiang You, Tinghao Yuan, Jun He, Qiang Tu.
       BACKGROUND AND PURPOSE: Ubiquitination modifications can affect hepatocellular carcinoma (HCC) progression through various signaling pathways. However, no significant results have been observed regarding protein ubiquitination in HCC's therapeutic transformation. This study aimed to explore the research areas related to ubiquitination and HCC from a bibliometric perspective.
    METHODS: Articles and reviews on HCC and ubiquitination published between 2000 and 2023 were obtained from the Web of Science Core Collection (WOSCC). CiteSpace, VOSviewer, and R-bibliometrix were used for the bibliometric and visualization analyses.
    RESULTS: Altogether, 358 papers on ubiquitination and HCC were extracted from the WOSCC. Over 24 years, the number of publications has increased. Since the beginning of 2019, studies related to this topic have increased significantly, indicating that the role of ubiquitination modification in HCC is currently popular. China is the leading country in this field with the largest number of publications. The Chinese Academy of Sciences is one of the most influential institutions. Qiao, Yongxia, and Zhang Jie are highly productive authors with major achievements. The journal Cell Death & Disease had the highest number of publications, and the most highly cited journal was Oncogene. The highest citation burst intensity was Sung (2021). In the keyword strategy map, "cancer antigens" are popular keywords in HCC and ubiquitination research.
    CONCLUSION: A comprehensive visual analysis of ubiquitination and HCC research was conducted using bibliometric methods, showing the publications and popular topics in this field over the past two decades, thus providing references for the future direction of ubiquitination and HCC research.
    Keywords:  Bibliometric analysis; CiteSpace; Hepatocellular carcinoma; Ubiquitination; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-02155-5
  27. Front Pediatr. 2025 ;13 1515251
    Bibliometric analysis of Crohn's disease in children, 2014-2024.
    Yanjing Zhu, Yunhong Ma, Zhengjiu Cui, Yueli Pan, Juanjuan Diao.
       Background: In recent years, the incidence of Crohn's disease has risen significantly in the pediatric population, and its prolongation has had a major impact on children's physical and mental health as well as on the quality of life of their families, and has therefore received extensive attention from scholars around the world. A large number of articles have been published on Crohn's disease in children; however, there is still a lack of studies that use visualization methods for bibliometric analysis of relevant literature. The purpose of this paper is to statistically analyze the published literature in the field of Crohn's disease in children in order to help in the future diagnosis and treatment of Crohn's disease in children.
    Methods: Literature meeting the inclusion criteria was screened from the Web of Science Core Collection database. Literature was visualized and analyzed by author, country, institution, journal, reference, and keyword using Citespace (6.2.R4) and VOSviewer (1.6.18).
    Results: A total of 3,177 eligible publications were included. There is an overall increasing trend in the number of annual publications.Turner, Dan published the most number of articles with 78 and has a high impact in the field of CD. The most cited author was Levine, A. Among countries and institutions, the United States and Tel Aviv University had the highest number of publications. The journal with the most publications is Journal Of Pediatric Gastroenterology And Nutrition. The most co-cited journal was Inflammatory Bowel Diseases. The most cited document was ESPGHAN Revised Porto Criteria for the Diagnosis of Inflammatory Bowel Disease in Children and Adolescents, and the most cited document with the highest outbreak intensity was The Medical Management of Paediatric Crohn's Disease: an ECCO-ESPGHAN Guideline Update.The most frequent keyword was "inflammatory bowel disease".
    Conclusion: This study provides a visual summary of information for the field of pediatric Crohn's disease and contributes to international collaboration to promote research in the field of pediatric Crohn's disease.
    Keywords:  VOSviewer; bibliometric analysis; childhood Crohn's disease; citespace; visual analysis
    DOI:  https://doi.org/10.3389/fped.2025.1515251
  28. Mol Cancer. 2025 Mar 17. 24(1): 81
    Shifting landscapes of gender equity in oncology journals: a decade of authorship trends.
    Hang Yi, Mingzhong Wan, Xu Ou-Yang, Yang Wang, Yan Wang, Yinyan Gao, Qihao Leng, Shuangping Zhang, Yousheng Mao, Guochao Zhang.
       BACKGROUND: Gender disparities persist in academic oncology, particularly in authorship and senior academic roles. This study evaluates trends in authorship gender representation over the past decade across top oncology journals, focusing on regional, journal-specific, and citation-based disparities.
    METHODS: A cross-sectional analysis was conducted on 29,005 articles published between 2014 and 2023 in the top 20 oncology journals, identified through the Web of Science database. Author gender was determined using the NamSor tool. Temporal trends were analyzed using linear regression, and multivariate logistic regression identified factors contributing to gender disparities. Regional and citation analyses explored geographic variations and citation count differences.
    RESULTS: Among analyzed articles, 41.81% of first authors and 29.93% of last authors were female. Female first authorship showed a significant upward trend (P < 0.01), with gender parity projected by 2034, while parity for last authors is expected by 2055. Regional differences were notable, with North America and Europe leading in female representation. Certain journals, such as CA: A Cancer Journal for Clinicians and Molecular Cancer, exhibited higher female authorship proportions, while Journal of Clinical Oncology had the lowest. Citation analysis revealed female-authored articles received significantly fewer citations than male-authored ones (P < 0.01).
    CONCLUSIONS: Although female authorship in oncology journals has increased over the past decade, disparities remain, particularly in senior roles and citation impact. Addressing these issues requires targeted strategies, including mentorship programs, greater female representation in editorial boards, and institutional policies promoting gender equity.
    Keywords:  Academic equity; Authorship trends; Citation analysis; Gender disparities; Oncology
    DOI:  https://doi.org/10.1186/s12943-025-02286-x
  29. Support Care Cancer. 2025 Mar 18. 33(4): 296
    Research hotspots and trends in cancer rehabilitation: a bibliometric analysis (2013-2023).
    Ruijuan Cai, Hongsheng Lin, Qiyuan Mao, Chuchu Zhang, Ying Tan, Qianwen Cheng.
       BACKGROUND: Advances in medical care have made cancer rehabilitation an essential component of comprehensive cancer treatment. However, bibliometric analyses in this field remain limited. This study maps the global research landscape of cancer rehabilitation over the past decade.
    METHODS: Relevant publications on cancer rehabilitation from 2013 to 2023 were retrieved from the Web of Science Core Collection (WoSCC) database. Bibliometric analysis was conducted using VOSviewer, CiteSpace, and the R package "Bibliometrics."
    RESULTS: A total of 6743 publications from 98 countries demonstrated sustained growth, peaking in 2022. The USA (1581 publications) and China (974) led in research output, while the Netherlands recorded the highest citation impact (32.75 citations per paper). Key institutions included the University of Texas MD Anderson Cancer Center (148 publications) and Memorial Sloan Kettering Cancer Center (40.58 citations per paper). Supportive Care in Cancer ranked as the most influential journal. Research efforts primarily focused on exercise interventions (n = 404), quality of life (n = 688), and breast cancer rehabilitation (n = 440). Recent trends highlighted telemedicine, digital health, and breast cancer-related lymphedema.
    CONCLUSION: This analysis highlights the dominance of high-income countries in cancer rehabilitation research and identifies exercise, quality of life, and breast cancer as enduring focal points. Emerging priorities include technology-driven interventions and lymphedema management. However, critical gaps remain, such as the underrepresentation of low-resource regions, limited focus on pediatric populations, and insufficient integration of advanced technologies (e.g., AI, wearables). Future efforts should emphasize equitable resource distribution, evidence-based pediatric rehabilitation models, and scalable technology-driven solutions to address global disparities and improve survivorship care.
    Keywords:  Bibliometrics; Cancer rehabilitation; Hotspots; Research activity; Trends
    DOI:  https://doi.org/10.1007/s00520-025-09355-3
  30. Medicine (Baltimore). 2025 Mar 14. 104(11): e41830
    Knowledge mapping of Guillain-Barré syndrome from January 2013 to October 2023: A bibliometric analysis.
    Xue Kang, Guowei Wang, Bin Liu, Zhenhai Wang.
       BACKGROUND: With the COVID-19 pandemic and the serious sequelae, foreign factor-induced Guillain-Barré syndrome (GBS) has become a research focus in autoimmune peripheral neuropathies. The study employs a bibliometric system to illustrate the research hotspots and trends in GBS based on pertinent literature from January 2013 to October 2023.
    METHODS: The Web of Science Core Collection retrieved articles on GBS from January 1, 2013, to October 28, 2023. These articles were then visualized and statistically evaluated using VOSviewer, CiteSpace software, R version 4.2.1, and Microsoft Office Excel 2019.
    RESULTS: A total of 4269 articles on GBS were gathered. The United States of America produced the most publications (28.55%, 1219/4269), followed by China (14.22%, 607/4269). The world's leading country was the United States of America, with the most publications, the most substantial international cooperation, and the highest centrality (0.17). Union of French Research Universities (UDICE)-French Research Universities in France was the most productive organization (189 articles). Lancet was the highest cocited journal (2428), and Professor Jacobs, Bart C., was the most prolific author (93). The most significant increases were shown for the keywords coronavirus, respiratory failure, and coronavirus disease 2019. The novel coronavirus is an emerging virus that may cause GBS, indicating a promising area of research.
    CONCLUSIONS: The study on GBS was illustrated using bibliometrics, and it covers trends in international collaboration, publications, and research hotspots. These findings allow the scientific community to pinpoint the novel ideas and directions that will drive future GBS research.
    DOI:  https://doi.org/10.1097/MD.0000000000041830
  31. World J Transplant. 2025 Mar 18. 15(1): 99642
    Machine learning in solid organ transplantation: Charting the evolving landscape.
    Badi Rawashdeh, Haneen Al-Abdallat, Emre Arpali, Beje Thomas, Ty B Dunn, Matthew Cooper.
       BACKGROUND: Machine learning (ML), a major branch of artificial intelligence, has not only demonstrated the potential to significantly improve numerous sectors of healthcare but has also made significant contributions to the field of solid organ transplantation. ML provides revolutionary opportunities in areas such as donor-recipient matching, post-transplant monitoring, and patient care by automatically analyzing large amounts of data, identifying patterns, and forecasting outcomes.
    AIM: To conduct a comprehensive bibliometric analysis of publications on the use of ML in transplantation to understand current research trends and their implications.
    METHODS: On July 18, a thorough search strategy was used with the Web of Science database. ML and transplantation-related keywords were utilized. With the aid of the VOS viewer application, the identified articles were subjected to bibliometric variable analysis in order to determine publication counts, citation counts, contributing countries, and institutions, among other factors.
    RESULTS: Of the 529 articles that were first identified, 427 were deemed relevant for bibliometric analysis. A surge in publications was observed over the last four years, especially after 2018, signifying growing interest in this area. With 209 publications, the United States emerged as the top contributor. Notably, the "Journal of Heart and Lung Transplantation" and the "American Journal of Transplantation" emerged as the leading journals, publishing the highest number of relevant articles. Frequent keyword searches revealed that patient survival, mortality, outcomes, allocation, and risk assessment were significant themes of focus.
    CONCLUSION: The growing body of pertinent publications highlights ML's growing presence in the field of solid organ transplantation. This bibliometric analysis highlights the growing importance of ML in transplant research and highlights its exciting potential to change medical practices and enhance patient outcomes. Encouraging collaboration between significant contributors can potentially fast-track advancements in this interdisciplinary domain.
    Keywords:  Artificial Intelligence; Bibliometric analysis; Machine learning; Solid organ transplantation
    DOI:  https://doi.org/10.5500/wjt.v15.i1.99642
  32. Eur J Obstet Gynecol Reprod Biol. 2025 Mar 14. pii: S0301-2115(25)00161-7. [Epub ahead of print]309 79-88
    Knowledge mapping for prediction of spontaneous preterm birth.
    Hui Shen, Lihe Zhang, Han Bai, Lihong Wu, Liu Du, Hongning Xie.
       INTRODUCTION: Preterm birth (PTB) before 37 weeks gestation, especially spontaneous premature birth (sPTB), poses significant global health challenges, with rising rates linked to advanced and multiple pregnancies. Despite efforts to understand the pathogenesis and related biomarkers of sPTB, accurate prediction is still difficult to achieve. Recent research in academic journals has focused on sPTB prediction, prompting our bibliometric analysis to understand the current situation and explore the new research direction.
    METHODS: We used keywords in the Web of Science Core Collection (WoSCC) to search for articles related to sPTB prediction from 2004 to 2023. Subsequently, we primarily employed three distinct software tools (VOSviewer, CiteSpace, and Python) for conducting this bibliometric analysis.
    RESULTS: Focusing on sPTB as the primary subject, a total of 647 papers have been published in 136 academic journals. There are the most publications from The United States (n = 245, 39.26 %), and the University of London contributed the most publications (n = 57, 8.81 %). The American Journal of Obstetrics and Gynecology is the most productive academic journal on sPTB prediction [n = 74, 11.44 %; impact factor (IF) = 8.7]. Through the co-occurrence and cluster analysis, we found that recent research has focused on is "pamg-1", "uterocervical angle", "twin pregnancy", "quantitative ultrasound", and "lactobacillus iners".
    CONCLUSION: We utilized bibliometric software to perform a comprehensive analysis of the literature concerning sPTB prediction. Broadly, the primary focus of future sPTB prediction lies in the application of novel ultrasound and biological markers, as well as in predicting sPTB in twin pregnancies.
    Keywords:  Bibliometric study; CiteSpace; Prediction; Spontaneous premature birth; VOSviewer
    DOI:  https://doi.org/10.1016/j.ejogrb.2025.03.023
  33. Discov Oncol. 2025 Mar 15. 16(1): 321
    Research trends of neoadjuvant therapy in lung cancer: a bibliometric analysis.
    Xiaoru Geng, Youqin Jiang, Yichun Zeng, Wenmiao Cao, Yao Lu, Yichen Liang, Juan J Gu, Buhai Wang.
       BACKGROUND: Lung cancer is the most prevalent malignancy worldwide. Only a fraction of early-stage patients undergo radical surgery; however, many still experience recurrence and metastasis within 5 years postoperatively (approximately 30-75%). Neoadjuvant therapy has revolutionized the treatment approach for lung cancer, with a growing number of clinical trials investigating this modality. This study provides a comprehensive analysis of neoadjuvant therapy in lung cancer, intending to guide future research.
    METHOD: To extract literature on neoadjuvant therapy for lung cancer published in the Web of Science Core Collection, spanning January 1, 2004, to December 31, 2023. Utilizing software tools including VOSviewer, CiteSpace, and GraphPad Prism to conduct bibliometric analysis and visualization studies on countries, institutions, journals, authors, co-cited references, and keywords in this field.
    RESULTS: A sum of 6,085 research publications from 84 countries were analyzed, with the United States leading in publications on neoadjuvant therapy for lung cancer. The institution that publishes the most articles is the University of Texas System. The most published journal is Annals of Thoracic Surgery, while the most frequently co-cited journal is Journal of Clinical Oncology. Eight of the top ten co-cited references concern immune checkpoint inhibitors(ICIs). Keyword burst analysis indicates that the current research focuses and trends mainly center around four areas: ICIs, clinical trials, efficacy, and non-small cell lung cancer (NSCLC).
    CONCLUSIONS: This is the first bibliometric study of neoadjuvant therapy in lung cancer. Over the past two decades, interest in this field has steadily increased, particularly since 2017. The United States is the largest contributor and has the highest number of publications in this field. Immune checkpoint inhibitors, clinical trials, efficacy, and NSCLC are hotspots in neoadjuvant therapy for lung cancer, both now and in the foreseeable future.
    Keywords:  Bibliometric analysis; Efficacy; Immune checkpoint inhibitors; Lung cancer; Neoadjuvant therapy
    DOI:  https://doi.org/10.1007/s12672-025-02011-6
  34. Gland Surg. 2025 Feb 28. 14(2): 153-162
    Ultrasound-guided thermal ablation therapy for papillary thyroid carcinoma: a bibliometric analysis from 2000 to 2023.
    Junping Zhang, Shanshan Li, Mengya Zhu, Wen Chen, Anqi Huo, Yuanyuan Deng, Fang Lu, Ying Liu, Jixiong Xu.
       Background: Papillary thyroid cancer (PTC) is increasingly treated with procedures. However, there is a lack of relevant systematic evaluation articles. Therefore, this study aims to explore the research landscape of PTC thermal ablation through bibliometric analysis.
    Methods: We searched publications related to PTC thermal ablation therapy from January 1, 2000 to December 31, 2023, from the Web of Science Core Collection (WoSCC). Subsequently, bibliometric analyses were then performed using the R package "bibliometrix", as well as VOSviewer and CiteSpace software, to visualize data on countries, institutions, journals, authors, keywords, and references.
    Results: A total of 283 publications from 17 countries were retrieved, and the number of publications had shown a steady increase over the past decade, with China, the USA and South Korea being the top three contributing countries. The Chinese People's Liberation Army General Hospital was the most prolific institution, with the International Journal of Hyperthermia being the most frequent publisher. The author with the highest number of publications was Yukun Luo. "Radiofrequency ablation" was identified as the most commonly used keyword, indicating a potential research hotspot for the future.
    Conclusions: This bibliometric study comprehensively analyzed publications on PTC thermal ablation, providing valuable insights into the history and current status of this research field, while also offering guidance for future research directions.
    Keywords:  Papillary thyroid carcinoma; bibliometric analysis; thermal ablation; ultrasound
    DOI:  https://doi.org/10.21037/gs-24-466
  35. Discov Oncol. 2025 Mar 20. 16(1): 366
    Analyzing research trends in the relationship between immunosuppressants and cancer following organ transplantation: a bibliometric study from 2001 to 2023.
    Xing Liu, Ren-Chun Du, Jing-Yuan Xu, Yu-Xin Hu, Xun Xie, Qing-Yang Lan, Liaoliao Hu.
       BACKGROUND: Recently, there has been an increasing interest in investigating the potential benefits or risks associated with using immunosuppressants for treating specific tumors post organ transplantation, with a focus on selecting appropriate drugs, doses, and treatment protocols. This study used bibliometric analysis to evaluate research trends and hotspots in this field.
    MATERIALS AND METHODS: A systematic search was conducted on the Web of Science to identify studies focusing immunosuppressants and cancer following organ transplantation from 2001 to 2023. The search strategy utilized a variety of the keywords including "immunosuppressants", "cancer" and "transplant". Data extraction involved recording various parameters such as title, author, institution, country, publication, citation, H-index, immunosuppressant, and type of transplantation.
    RESULTS: The analysis encompassed a total of 94 studies. The findings revealed that the period from 2005 to 2010 emerged as the most influential timeframe within this research. The United States ranked highest in the number of publications, with Vivarelli M identified as the most productive author, and the University of Bologna recognized as the most productive institute. "Immunosuppression", "rapamycin" and "kidney" were identified as the key hotspots within this field. Notably, rapamycin was identified as the predominant immunosuppressant and kidney transplantation emerged as the most prominent type of transplantation.
    CONCLUSIONS: While immunosuppressants have been extensively utilized in organ transplant procedures, certain associated cancer risks have not been well addressed. Further long-term monitoring studies are required for numerous immunosuppressants to elucidate precise applications and potential implications for solid-organ transplant recipients.
    Keywords:  Bibliometric analysis; Cancer; Immunosuppressants; Research trends; Transplantation
    DOI:  https://doi.org/10.1007/s12672-025-02101-5
  36. Front Nutr. 2025 ;12 1561792
    A bibliometric analysis of current research, development status, and future development trends of soy and whey proteins.
    Meng-Jie Li, Duo Feng, Meng-Han Ma, Di Han, Hu Li, Na Li, Tian-Xin Liu, Jia-Yu Fan, Jing Wang.
       Objective: This study aimed to analyse the current status and development of research on soy and whey proteins during the period 2004-2024 using bibliometric methods in order to reveal the research hotspots and development trends in this field.
    Methods: The study used CiteSpace and VOSviewer software to visualise and analyse 1,888 articles in the core database of Web of Science, including collaboration mapping, co-occurrence mapping, and co-citation mapping, in order to detect the development of disciplinary knowledge areas, research hotspots, frontiers, and trends.
    Results: The study found an overall fluctuating increase in the publication of relevant literature, especially a significant increase between 2016 and 2023. China has the most prominent research contribution in this field and maintains close collaboration with several countries. Keyword analysis revealed that research hotspots include antioxidant properties, sodium caseinate, pH effects, and colorectal cancer, and that research is gradually changing from process physicochemical properties to nutritional health. However, there were some limitations in this study, such as the narrow subject matter of the dataset, some high-quality literature may not be valued due to low citation rates, and there was a delay in updating the database, which affected the timeliness of the analysis.
    Conclusion: Over the past two decades, research on soy and whey proteins has witnessed a shift from processing aspects to nutrition and health, reflecting the emphasis and in-depth exploration of the nutritional and health values of proteins. Despite its limitations, this study provided a valuable reference for researchers in the field of soy and whey proteins, helping them to grasp the direction of their research and rationally allocate resources. At the same time, it also provided data support for policymakers to formulate relevant research policies and promote international cooperation, which will help to promote the further development and innovation of proteins in the field of nutrition. Therefore, it was recommended that research institutes strengthen their cooperation and work together to meet future research challenges and promote the sustainable development of proteins in nutrition.
    Keywords:  Citespace; bibliometric; dual protein; soy protein; whey protein
    DOI:  https://doi.org/10.3389/fnut.2025.1561792
  37. Pathog Glob Health. 2025 Mar 16. 1-12
    Temporal trends in diagnostic evolutions for rickettsial diseases including scrub typhus: a bibliometric study.
    Rashi Dixit, Sandeep Manikandan, Natarajan Gopalan, Bhabani Shankar Mohanty, Sujit Kumar Behera.
      The bibliometric analysis aimed to assess the bibliometric characteristics, current status and temporal trends in diagnostic evolutions related to infectious diseases caused by the genus Orientia and Rickettsia. Relevant studies were retrieved from Scopus using pre-determined standard keywords. The analysis was performed using the R package 'Bibliometrix' through the 'Biblioshiny' interface. A total of 239 studies were identified for Rickettsia diagnostics, while 168 studies focussed on scrub typhus diagnostics. The annual growth rate of publications in scrub typhus (1.82%) was found to be higher than that of diagnostic research in Rickettsia (1.44%). The Journal of Clinical Microbiology (IF: 5.8) was the most relevant source for Rickettsia research, whereas the American Journal of Tropical Medicine and Hygiene (IF: 3.7) led publications for scrub typhus. The most globally cited articles were authored by Biggs et al (2017) for Rickettsia and Blacksell et al. (2007) for scrub typhus. U.S.A. (n = 119) and India (n = 136) are the most productive nations, publishing in Rickettsia and scrub typhus diagnostics. Mahidol University (Thailand) and the University of Texas (U.S.A.) were the top-contributing institutions. Blacksell S.D. and Raoult D. were identified as the most prolific researchers in Rickettsia and scrub typhus diagnostics. This study provides insights into the impact, productivity, and collaborative patterns among authors, institutions, and other stakeholders in rickettsial disease diagnostics. It offers a historical overview of diagnostic developments and emphasizes the importance of continued innovation and international collaboration to ensure timely diagnosis and treatment of rickettsial diseases.
    Keywords:  Bibliometrics; Orientia; Rickettsia; bibliometric analysis; diagnostics; scrub typhus; spotted fever; typhus fever
    DOI:  https://doi.org/10.1080/20477724.2025.2475278
  38. Front Oncol. 2025 ;15 1523465
    Hotspots and trends in gastric cancer stem cell research: a visualization and bibliometric analysis.
    Jinfeng Liu, Xinhui Han, Qingyi Wang, Sihui Qin, Yujie Xi, Guoying Liang.
       Background: Gastric cancer (GC) is a type of malignant tumor that seriously endangers human health. As the understanding of the mechanisms underlying gastric cancer deepens, in recent years, investigations on gastric cancer stem cells (GCSCs) have garnered significant interest. They are pivotal in the onset, progression, recurrence, and pharmacoresistance of GC. Comprehensive research on GCSCs is expected to provide new strategies for the diagnosis and treatment of GC. This article endeavors to comprehensively assess the current status and future trends of GCSCs research through bibliometric analysis, thereby providing a valuable reference for further in - depth studies in this field.
    Methods: English - language academic journals related to GCSCs research in the Web of Science database were retrieved. Subsequently, VOSviewer was utilized to conduct network collinear analysis of the exported source institutions, literature authors, references, and keywords. And CiteSpace was used to perform statistical analysis of the annual publication count, keyword clustering, references, and keyword burst.
    Results: A total of 3882 documents that met the criteria were incorporated. The quantity of published papers has shown a consistent upward trend annually since 2003. Among the authors of the literature, multiple stable core author groups represented by Zhu, Wei, Wang, Mei, Xu, Wenrong, etc. have been formed. There are 335 associated institutions in total. The Japan National Cancer Center has the strongest relevance and the largest number of published papers. There are 7 clustering labels formed among the keywords, including main clustering modules such as activation, cancer stem cells, DNA content aneuploidy, and expression. 25 burst keywords were generated, and the burst keywords in the past two years include mesenchymal stem cells, drug resistance, proliferation, etc. The emergence of references indicates that eight references have been cited up to now and are the focus of current research.
    Conclusion: The research overview of GCSCs in the past 30 years was visually presented by visual maps. In the past decade, scholars' research in this field has gradually intensified, and the development trend is good. Through the deeper study of the GCSCs mechanism, intervention GCSCs in the future will be a new promising treatment approach for GC patients. This hot topic still deserves more attention in the future.
    Keywords:  CiteSpace; VOSviewer; bibliometric analysis; gastric cancer stem cells; visualization
    DOI:  https://doi.org/10.3389/fonc.2025.1523465
  39. Neuroscience. 2025 Mar 14. pii: S0306-4522(25)00184-8. [Epub ahead of print]573 9-24
    Mapping the landscape of neuroscience research trend(s) in South Asia: A bibliometric analysis of 25 years (1995-2019).
    Sara Ishaq, Armeen Hameed, Amna Liaqat, Humna Asghar, Lubna Kanwal, Laila Tul Qadar, Natasha Naeem, Saba Mehak Zahoor, Touqeer Ahmed.
      In depth analysis of publication trends can help in finding out strengths, weaknesses and areas for improvement. South Asia (SA), with its unique demographic and epidemiological characteristics, is considered a valuable region for health research, particularly in neuroscience. There is a clear need of data which should reflect heterogenous neuroscience research outputs of the SA region and help in devising new trends to boost its research landscape. The present study aimed to analyse the neuroscience research trend in SA during the recent 25 years (1995 to 2019). A total of 85,796 articles were retrieved from PubMed using 7 keywords in combination with the SA country's name. These articles were filtered by removing paper not falling in neurosciences. We compared important metrics of these articles from SA countries. Moreover, data from SA countries were compared with data (extracted similarly) from 4 developed countries i.e., Germany, USA, UK, and Japan (750 articles each). The metrics compared include, journal impact factor (IF), number of authors, citations, funding, collaborations, and research categories. This unique dataset has shown that SA is although, making a lot of progress in neuroscience research, still there is a need for further improvement especially in funding, publications in high IF journals, and the use of advanced cutting-edge technologies. Our study helps in highlighting important gaps and making crucial recommendations to promote neuroscience in the region.
    Keywords:  Bibliometric; Neuroscience; Research categories; South Asia
    DOI:  https://doi.org/10.1016/j.neuroscience.2025.03.003
  40. Syst Rev. 2025 Mar 15. 14(1): 62
    Global output of clinical application research on artificial intelligence in the past decade: a scientometric study and science mapping.
    Ji-Yuan Shi, Shu-Jin Yue, Hong-Shuang Chen, Fei-Yu Fang, Xue-Lian Wang, Jia-Jun Xue, Yang Zhao, Zheng Li, Chao Sun.
       BACKGROUND: Artificial intelligence (AI) has shown immense potential in the field of medicine, but its actual effectiveness and safety still need to be validated through clinical trials. Currently, the research themes, methodologies, and development trends of AI-related clinical trials remain unclear, and further exploration of these studies will be crucial for uncovering AI's practical application potential and promoting its broader adoption in clinical settings.
    OBJECTIVE: To analyze the current status, hotspots, and trends of published clinical research on AI applications.
    METHODS: Publications related to AI clinical applications were retrieved from the Web of Science database. Relevant data were extracted using VOSviewer 1.6.17 to generate visual cooperation network maps for countries, organizations, authors, and keywords. Burst citation detection for keywords and citations was performed using CiteSpace 5.8.R3 to identify sudden surges in citation frequency within a short period, and the theme evolution was analyzed using SciMAT to track the development and trends of research topics over time.
    RESULTS: A total of 22,583 articles were obtained from the Web of Science database. Seven-hundred and thirty-five AI clinical application research were published by 1764 institutions from 53 countries. The majority of publications were contributed by the United States, China, and the UK. Active collaborations were noted among leading authors, particularly those from developed countries. The publications mainly focused on evaluating the application value of AI technology in the fields of disease diagnosis and classification, disease risk prediction and management, assisted surgery, and rehabilitation. Deep learning and chatbot technologies were identified as emerging research hotspots in recent studies on AI applications.
    CONCLUSIONS: A total of 735 articles on AI in clinical research were analyzed, with publication volume and citation counts steadily increasing each year. Institutions and researchers from the United States contributed the most to the research output in this field. Key areas of focus included AI applications in surgery, rehabilitation, disease diagnosis, risk prediction, and health management, with emerging trends in deep learning and chatbots. This study also provides detailed and intuitive information about important articles, journals, core authors, institutions, and topics in the field through visualization maps, which will help researchers quickly understand the current status, hotspots, and trends of artificial intelligence clinical application research. Future clinical trials of artificial intelligence should strengthen scientific design, ethical compliance, and interdisciplinary and international cooperation and pay more attention to its practical clinical value and reliable application in diverse scenarios.
    DOI:  https://doi.org/10.1186/s13643-025-02779-2
  41. Int J Nanomedicine. 2025 ;20 2937-2968
    The Current Status, Hotspots, and Development Trends of Nanoemulsions: A Comprehensive Bibliometric Review.
    Guojun Sun, Liying Wang, Zuojun Dong, Yanxiao Zhang, Yan Yang, Miao Hu, Hui Fang.
      Nanoemulsions, which are characterized by their nanometer-scale droplets, have gained significant attention in different fields, such as medicine, food, cosmetics, and agriculture, because of their unique properties. With an increasing number of countries engaging in research on nanoemulsions, interest in their properties, preparation methods, and applications has increased. Hence, tracing the relevant research on nanoemulsions published in the past ten years on a global scale, by conducting data mining and visualization analysis on a sufficiently large text dataset through bibliometrics, sorting out and summarizing certain indicators, the development history, research status and research hotspots in the field of nanoemulsions can be clearly revealed, providing reference value and significance for subsequent research. This bibliometric review examines the research landscape of nanoemulsions from 2013-2023 via the SCI-E and SSCI databases, providing insights into the current status, hotspots, and future trends of this field. To offer a comprehensive overview, this analysis includes publication counts, author keywords, institutional contributions, research areas, prolific authors, highly cited papers and hot research papers. The findings reveal that China led in nanoemulsions research, followed by USA, India, and Brazil, with the University of Massachusetts emerging as a key player with the highest average number of citations per article (ACPP) and h-index. Food Chemistry, Pharmaceutics, and the Journal of Drug Delivery Science and Technology are among the top journals publishing in this area. Chemistry, pharmacology, and pharmacy emerged as the primary research domains, with McClements DJ as the most prolific and influential author. In keyword analysis, essential oil nanoemulsions are currently the main preparation direction, and various characteristics of nanoemulsions, such as their bioavailability, stability, biocompatibility, and antioxidant and antibacterial properties, have also been studied extensively. Research hotspots are focused mostly on the development of new applications and technologies for nanoemulsions.
    Keywords:  bibliometrics; bioavailability; drug delivery; essential oil; keyword analysis; nanoemulsions
    DOI:  https://doi.org/10.2147/IJN.S502490
  42. Front Aging Neurosci. 2025 ;17 1525626
    Knowledge domain and emerging trends in post-stroke cognitive impairment: a bibliometric analysis.
    Heyu Zhang, Yanwei Li, Luqian Zhan, Jingfang Long, Jianing Shen, Jiahui Chen, Jiajing Qian, Zhiming Pan, Xue Wu, Zhen Wang, Wenjun Wu, Guiqian Huang.
       Background: Cognitive impairment is an important cause of disability and death among the elderly. One of the most important risk factors is stroke. Post-stroke cognitive impairment (PSCI) not only diminishes the quality of life for patients but also increases the burden on families and society. But PSCI can be mitigated through early intervention. Cerebral small vessel disease (CSVD) is one of the significant causes of stroke and has garnered considerable attention in PSCI. Therefore, this study aims to identify research priorities and trends in PSCI through bibliometric analysis, and further explore the role played by CSVD in PSCI.
    Methods: In this study, we performed a systematic search in the Science Citation Index Expanded (SCI-E) of the Web of Science Core Collection (WoSCC). VOSviewer, CiteSpace and Origin were mainly used to visualize the research focus and trend in PSCI. In addition, we screened the retrieved literature again, and performed keyword analysis on the studies related to CSVD.
    Results: A total of 1,943 publications were retrieved in the field of PSCI in this study, with consistent upward trend in annual publications in recent years. Pendlebury was an important leader in PSCI research. Capital Medical University was in the leading position judging from the number of publications. China had the highest number of publications in this field. The journal Stroke had the strongest international influence in this field. Keywords such as "functional connectivity," "tool," "systematic review," and "meta-analysis" have been revealed to have momentous impact on PSCI in recent years. In the further analysis of PSCI and CSVD, "hypertension," "white matter hyperintensities (WMH)," "cerebral microbleeds (CMBs)," and "cerebral amyloid angiopathy (CAA)" received extensive attention.
    Conclusion: The study of PSCI is still in the development stage. This study systematically summarizes the progress and development trend in the field of PSCI, and further explores the relationship between CSVD and PSCI through hypertension and magnetic resonance imaging markers. This study is of great significance for researchers to quickly understand the development of PSCI, but also helps them understand future directions, and provides important insights for the prevention and treatment of PSCI.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; cerebral small vessel disease; cognitive impairment; post-stroke cognitive impairment; stroke; visual analytics
    DOI:  https://doi.org/10.3389/fnagi.2025.1525626
  43. Transpl Immunol. 2025 Mar 16. pii: S0966-3274(25)00046-2. [Epub ahead of print]90 102218
    Immunotherapy research in the Arab world: A bibliometric analysis.
    Ahmad Afyouni, Jana Kotaich, Sara Sarout, Amarelle Chamoun, Georgia Chkayban, Saad El Hariri, Tarek Baroud, Adnan Fatfat, Jad El Masri, Pascale Salemeh.
       BACKGROUND: Immunotherapy is the concept of leveraging the immune system to treat diseases. Developing countries, including the Arab countries, have continued to lag in terms of biomedical research compared to other nations for several decades. Immunotherapy has been used in several fields, including cancer, transplantation, and vaccination. This article examined the activity and trend of immunotherapy research in the Arab world between 2000 and 2024.
    METHODS: The number of immunotherapy-related articles published by each Arab country, was assessed using the PubMed database between 2000 and 2024. Numbers were normalized with respect to each country's average population and average Gross Domestic Product (GDP).
    RESULTS: Arab countries contributed to 1.73 % of total immunotherapy papers. The number of immunotherapy publications has grown from 2000 to 2022, then decreased in the past 2 years. In terms of publications per million persons, Qatar ranked first (130.08 per million persons), while in terms of publications per national GDP, Lebanon ranked first (11.09 per billion US dollars). MeSH keywords VOSviewer showed a focus on vaccination, COVID-19, COVID-19 vaccines, and transplantation conditioning in the Arab world.
    CONCLUSIONS: This bibliometric analysis provides insight into the actualities and trends of immunotherapy research in the Arab world. This offers a general background for scientists, clinicians, funders, and decision-makers. Addressing the barriers that face immunotherapy research remains a cornerstone in the plan to improve the Arab world's output and contribution to this field.
    Keywords:  Arab world; Bibliometric analysis; Immunotherapy; PubMed; Research productivity
    DOI:  https://doi.org/10.1016/j.trim.2025.102218
  44. Biomed Pharmacother. 2025 Mar 20. pii: S0753-3322(25)00150-7. [Epub ahead of print]186 117956
    Chemotherapy against Toxoplasma gondii: A bibliometric analysis of in vitro and mouse model studies (2015-2024).
    Juliana Quero Reimão, Fernanda Ferreira Evangelista, Stephanie Ortega Alves, Tayline Torres, Josinara do Espirito Santo Lobo, Kayo Thiago Ribeiro Perroni, Rafael Meyer Mariante.
      Toxoplasmosis, caused by Toxoplasma gondii, is a widespread parasitic infection with significant health impacts, especially in immunocompromised individuals. Chemotherapy remains the main treatment, but current therapies are limited by side effects and contraindications. This bibliometric analysis reviews research from 2015 to 2024 to identify key trends and future directions for T. gondii chemotherapy. We used the Web of Science Core Collection database to identify original articles on chemotherapy and T. gondii published in the last ten years. After screening, the data was transferred to visualization tools, including VOSviewer, Bibliometrix, and CiteSpace, for comprehensive analysis. Our analysis covered 433 articles from 164 journals, authored by 2,346 researchers from 577 institutions across 48 countries. China, Egypt, the USA, Iran, and Brazil made the largest contributions in terms of both publications and citation counts. Leading authors based on publication output include Andrew Hemphill (University of Bern, Switzerland), Ahmad Daryani (Mazandaran University of Medical Sciences, Iran), and Chunmei Jin (Yanbian University, China). The highest citation counts were attributed to Andrew Hemphill, Wesley Van Voorhis (University of Washington, USA), and Kayode Ojo (University of Washington). Key journals shaping this area include Experimental Parasitology, Parasitology Research, and Antimicrobial Agents and Chemotherapy. The most-cited article is from the Journal of Medicinal Chemistry, describing a novel inhibitor of Calcium-Dependent Protein Kinase 1 (CDPK1) as a promising toxoplasmosis treatment. Emerging topics include nanocarrier-based delivery systems and natural product derivatives. This study offers a comprehensive overview and visual analysis of chemotherapy and T. gondii, highlighting key areas for future research.
    Keywords:  Biblioshiny; CiteSpace; Compounds; Drugs; Toxoplasmosis; VOSviewer
    DOI:  https://doi.org/10.1016/j.biopha.2025.117956
  45. Drug Des Devel Ther. 2025 ;19 1703-1719
    Research Trends of Tyrosine Kinase Inhibitors in EGFR-Mutated Non-Small Cell Lung Cancer: A Bibliometric Analysis.
    Xiaoyan Chang, Chenghao Wang, Linyou Zhang.
       Background: This study seeks to identify research trends and hotspots concerning tyrosine kinase inhibitors (TKIs) for the treatment of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) through a comprehensive bibliometric analysis.
    Methods: Publications on TKIs and EGFR-mutated NSCLC from 2006 to 2024 were analyzed using VOSviewer, CiteSpace, and R-bibliometrix to visualize collaboration, keyword co-occurrences, and research trends.
    Results: A total of 962 articles were analyzed, authored by 7,458 researchers from 5,401 institutions across 208 countries. Wu Yi-Long was identified as the most prolific author, contributing 30 publications. AstraZeneca emerged as the industrial leader with 103 articles, while the New England Journal of Medicine was recognized as the primary journal with the highest total link strength. Keyword co-occurrence analysis revealed significant research topics including "gefitinib", "chemotherapy", "open label", and "erlotinib." Moreover, keyword burst analysis indicated notable periods of increased research focus on topics such as "osimertinib" and "liquid biopsy", suggesting emerging trends and current hotspots in the treatment of EGFR-mutated NSCLC.
    Conclusion: This analysis highlights research trends on TKIs for EGFR-mutated NSCLC, emphasizing the importance of targeted therapies like gefitinib and osimertinib for future research and clinical practice enhancement.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; non-small cell lung cancer; tyrosine kinase inhibitors
    DOI:  https://doi.org/10.2147/DDDT.S510031
  46. Front Immunol. 2025 ;16 1501432
    Global trends and hotspots in macrophage research related to hypertension from 2015-2024: bibliometric research and visualization analysis.
    Xuefei Wang, Yemao Chai, Ye Dou, Xinyi Li, Fanghe Li, Kuo Gao.
       Background: Hypertension continues to be a global health and economic burden, conventionally characterized by a chronic inflammatory state. Macrophages are critical for the initiation, progression and manifestation of hypertension. As studies on the relationship between macrophages and hypertension increase substantially, identifying critical research areas and unraveling potential interaction mechanisms become increasingly essential.
    Methods: Articles associated with hypertension and macrophages in recent 10 years were retrieved from the Web of Science Core Collection for analysis, using Microsoft Excel, VOSviewer, CiteSpace and Scimago Graphica.
    Results: After excluding studies that did not meet inclusive standard based on time (2015-2024) and type (article or reviews), 2,013 original articles related to macrophages associated with hypertension were included. The number of publications has been increasing annually. These records consisted of 2,013 English language papers published in 351 journals by 315 institutions or regions from 83 countries/regions between 2015 and 2024. We analyzed the co-cited references clusters to objectively outline the current state of research, including the regulatory mechanisms of hypertension, diseases related to hypertension, and the lifestyle factor. Inflammation remains one of the most popular research hot-spot. The most popular publishing journal in this field is PLOS ONE and the most prolific writer is Li, Hui-Hua. The primary keywords cluster in this field is inflammation, with the highest occurrences and TLS among the top 10 keywords.
    Conclusion: These comprehensive and visualized bibliometric results summarized the significant findings in macrophage-related hypertension studies over the past 10 years. Macrophages appear to be effective in the treatment of hypertension as potential targets, but further research is needed to clarify the specific pathophysiological mechanisms involved.
    Keywords:  bibliometric; hotspots; hypertension; macrophage; visualization
    DOI:  https://doi.org/10.3389/fimmu.2025.1501432
  47. World J Gastrointest Oncol. 2025 Mar 15. 17(3): 100997
    Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots.
    Zhen Yuan, Jing-Hang Wang, Hao Cui, Shu-Yuan Wang, Bo Wei, Jian-Xin Cui.
       BACKGROUND: Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer (GC). A comprehensive review of advancements, current status, and research trends in GC immunotherapy is essential to inform future investigative efforts.
    AIM: To delineate the trends, advancements, and focal points in immunotherapy for GC.
    METHODS: We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20, 2023, indexed in the Web of Science Core Collection. Data analysis and visualization were facilitated by CiteSpace (6.1.6R), VOSviewer v.1.6.17, and GraphPad Prism v8.0.2.
    RESULTS: There has been an increase in the annual publication rate of GC immunotherapy research. China leads in publication volume, while the United States demonstrates the highest citation impact. Fudan University is notable for its citation frequency and publication output. Co-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis, the tumor microenvironment (TME), and integrative immunotherapy with targeted therapy. Emerging research areas include gastroesophageal junction cancer, adoptive immunotherapy, and the role of Treg cell in immunotherapy.
    CONCLUSION: GC immunotherapy research is an expanding field attracting considerable scientific interest. With the clinical adoption of immunotherapy in GC, the primary goals are to enhance treatment efficacy and patient outcomes. Unlike hematological malignancies, GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer cells. For instance, although CAR-T therapy is effective in hematological malignancies, it has underperformed in GC settings. Current research is centered on overcoming immunosuppression within the TME, with a focus on combinations of targeted therapy, adoptive immunotherapy, Treg cell dynamics, and precise prognosis prediction in immunotherapy. Additionally, immunotherapy's role in treating gastroesophageal junction cancer has become a novel research focus.
    Keywords:  Bibliometrics; Gastric cancer; Immune checkpoint inhibitor; Immunotherapy; Tumor microenvironment
    DOI:  https://doi.org/10.4251/wjgo.v17.i3.100997
  48. Aesthetic Plast Surg. 2025 Mar 20.
    Global Bibliometric Visualization of Epidermal Growth Factor in Wound Healing: A Comprehensive Literature Search.
    Sa'ed H Zyoud.
      Epidermal growth factor (EGF) is essential for both wound repair and the maintenance of healthy tissues. Numerous bibliometric studies have been published on wound healing; however, none have focused on EGF in wound healing. This study comprehensively analyzed scientific publications on the role of Epidermal Growth Factor (EGF) in wound healing. The analysis encompassed publications indexed in the Scopus database from 1972 to 2024, retrieved using a broad range of relevant keywords. Network analysis and visualization were subsequently conducted using VOSviewer (v. 1.6.20) to map research trends and identify research hotspots. My examination of the Scopus database identified 3122 articles on the use of EGF in wound healing published over the past 48 years (1972-2024). Most of these publications were research articles (n = 2812; 90.07%), followed by review articles (n = 244; 7.82%). The number of publications on the use of EGF in wound healing has increased significantly (R2=0.9449; p < 0.001) over the years. This study revealed that, during the past ten years, there has been an increasing amount of global research on the relationship between EGF and wound healing. The effectiveness and clinical applications of human EGF and EGFR signaling in cancer-related wound healing were the main topics of our study, which focused on EGF and wound healing overall. To improve patient outcomes and enhance the efficacy of wound healing, particularly in aesthetic and reconstructive surgery, this bibliometric analysis emphasizes the importance of ongoing research and collaboration in this field.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Bibliometric; EGF; Epidermal growth factor; Wound healing
    DOI:  https://doi.org/10.1007/s00266-025-04820-0
  49. Exp Clin Transplant. 2025 Feb;23(2): 87-96
    Management of the Brain Death Organ Donor: Results of a Comprehensive Bibliometric Analysis on Research, 1992-2024.
    Xiaohang Chen, Li Pan, Wei Zhou, Shaojun Ye, Chongxiang He, Yan Xiong, Cheng Zeng, Qifa Ye, Yan Xu, Xin Zhou.
       OBJECTIVES: Organ transplant is widely regarded as the optimal treatment for patients with end-stage organ failure; however, the scarcity of organs has evolved into a substantial medical and social dilemma. To gain insight into recent advancements in global research on brain death organ donor management, we compiled relevant literature for a comprehensive bibliometric analysis of the field.
    MATERIALS AND METHODS: We used the CiteSpace (6.2.R3) tool to perform a visualization analysis of the literature on management of organ donors after brain death, which we conducted with the Web of Science database.
    RESULTS: Using a time period from 1992 to 2024, we examined annual publication volume, countries, research institutions, authors, and journals associated with the management of organ donors after brain death. The 269 research articles originated from 37 countries and regions. The United States was the foremost country in publishing articles on the management of brain dead donors. Harvard University emerged as the leading publisher in this field of research. We noted the top 3 authors by publication volume as K. J. Wood, B. Gridelli, and T. Kawai. Visualization of hotspots and frontiers encompassed kidney transplant, intestinal failure, graft dysfunction, and organ donor evaluation, among other areas.
    CONCLUSIONS: Our comprehensive overview of the organ donation management field can serve as a valuable resource for researchers looking to delve deeper into the specific aspects, thereby contributing to the ongoing advancement of brain death organ donor management.
    DOI:  https://doi.org/10.6002/ect.2024.0235
  50. Int J Ophthalmol. 2025 ;18(3): 526-540
    Bibliometric and visualized analysis of research hotpots and future prospects in lacrimal duct obstruction disease (1900 to 2024).
    Ming-Hai Chen, Fang Bai, Hai Tao.
       AIM: To reveal the research hotspots, trends, and future prospects of lacrimal duct obstruction disease (LDOD) from 1900 to 2024 through the bibliometric and visualized analysis, providing a directional guidance for research in this field.
    METHODS: The Web of Science Core Collection database was used to retrieve relevant literature. Data analysis and visualization were conducted using VOSviewer 1.6.20 and CiteSpace 6.3.1, including annual publication volume, trends, research areas, country/region and institution distribution, journal and co-cited journal analysis, author and co-cited author analysis, keyword and burst keyword analysis, etc.
    RESULTS: The study included a total of 1481 articles, revealing an overall upward trend in research on LDOD, with ophthalmology being the predominant field. While the United States previously led research efforts, India and China have emerged as key contributors since 2015. Mohammad Javed Ali stands out as the most influential author in this research area. Ophthalmic Plastic and Reconstructive Surgery has published the highest number of related articles, whereas Ophthalmology has the highest co-citation. The current focal points of research include minimally invasive and precise modifications to dacryocystorhinostomy, along with intubation, new materials for stents, and disease pathogenesis.
    CONCLUSION: LDOD research has garnered widely attention and exhibits a steady upward trend. Since 1900, the United States, China, and India have been the leading contributors to this field. Ophthalmologists continue to be the primary driving force behind LDOD research. The findings of this study suggest that at the forefront of LDOD research, our focus has long been on refining and innovating surgical treatment. The minimally invasive and precise modification of lacrimal surgery, represented by dacryocystorhinostomy, is the ongoing developmental direction of this field. Rapid interdisciplinary integration and in-depth exploration of pathogenesis and allergic inflammation will lead to the emergence of new materials, innovative technologies, and safer clinical treatment protocols.
    Keywords:  bibliometric analysis; dacryocystorhinostomy; lacrimal drainage system; lacrimal duct obstruction disease; tear drainage system
    DOI:  https://doi.org/10.18240/ijo.2025.03.21
  51. Technol Health Care. 2025 Mar;33(2): 895-914
    Research progress and visual analysis of smart wearable devices for the elderly in the context of ageing 4.0.
    Xianru Shang, Zijian Liu, Zhigang Hu, Tianxing Yang, Chen Gong.
      BackgroundThe world's population is ageing quickly, making managing older people's health more difficult. Although smart wearable devices (SWDs) have gained attention as possible instruments for enhancing health outcomes in this population, it is still uncertain how useful and long-lasting they will be.Objectives: The purpose of this study is to methodically evaluate the advancement of academic research and development concerning SWDs for the aged, with an emphasis on the effects these diseases have on quality of life, illness prevention, and health management.Method: 649 publications published in the Web of Science Core Collection between 2013 and 2023 underwent bibliometric analysis. VOSviewer and CiteSpace software were used to assess topic changes, publishing trends, and citation patterns. Co-citation analysis was used to pinpoint important literature and research focus clusters.ResultsThe results show a notable rise in publications about SWDs for the aged, emphasising essential topics, including fall detection, technology adoption, and healthcare applications. According to the report, multidisciplinary research integration is expanding, and publications like IEEE SENSORS JOURNAL and SENSORS-BASEL are making significant contributions.ConclusionThe research emphasises the crucial need to conduct long-term monitoring studies to verify the health advantages of SWDs for senior citizens. It highlights the necessity for user-centred design and urges future research to concentrate on improving wearable technology accuracy to maximise its usefulness in managing geriatric health.
    Keywords:  bibliometrics; elderly; health; healthcare; smart wearable devices; smartwatch and elderly care; visual analysis
    DOI:  https://doi.org/10.1177/09287329241291375
  52. Front Neurol. 2025 ;16 1540909
    A visualization analysis of research on arterial compression hemostatic devices using VOSviewer and CiteSpace.
    Li Liu, Juan Xiong, Jianmei Xu, Ping Tu.
       Background: Cardiovascular and cerebrovascular diseases pose a significant health challenge in modern society, with the advancement of interventional therapy and vascular intervention technology playing crucial roles. In the context of post-interventional procedures, the application of suitable pressure at the puncture site is of utmost importance for achieving hemostasis. A variety of arterial compression devices are utilized in clinical settings to facilitate this critical step. A bibliometric analysis is used to assess the impact of research in a particular field. This study seeks to explore the research trends, key themes, and future directions of arterial compression hemostatic devices in international scholarly literature to inform future research endeavors.
    Methods: English-language literature on arterial compression hemostatic devices was systematically retrieved from the Web of Science (WOS) and Scopus databases until December 31, 2024. In this study, we employed VOSviewer 1.6.18 and CiteSpace 6.2.r4 to systematically analyze a comprehensive set of parameters, which included authorship and institutional affiliations, geographical distribution by country, and thematic categorization through keywords.
    Results: In total, 4,358 relevant publications were retrieved. This study's results section highlights a growing body of research on arterial compression hemostasis devices, with a significant increase in publications post-2000, reaching 107 in 2022. Department of Cardiology leads in institutional contributions, while 'Bernat, lvo' is the most prolific authors. Keyword analysis identifies "human," "article," "hemostasis," "female," and "male" as key terms, with 7 thematic clusters revealed by hierarchical clustering.
    Conclusion: The results provide an overview of research on arterial compression hemostatic devices, which may help researchers better understand classical research, historical developments, and new discoveries, as well as providing ideas for future research.
    Keywords:  cluster analysis; compression; hemostasis; nursing; radial artery; visual analysis
    DOI:  https://doi.org/10.3389/fneur.2025.1540909
  53. Medicine (Baltimore). 2025 Mar 14. 104(11): e41831
    Research status of risk factors and prevention of pancreatic cancer: A bibliometric and visual analysis.
    Lichen Song, Guihua Wang, Ziyi Chen, Guangming Wang.
      One of the biggest public health issues facing the globe today is pancreatic cancer (PC). To serve as a guide for clinically identifying existing research hotspots and conducting related studies in the future, bibliometric and visualization analyses of the literature on risk factors and PC prevention were carried out in this work. Results of published research from 2004 to 2024 were retrieved using the Web of Science database as a search platform. CiteSpace and VOSviewer were used for bibliometric and visual analysis. Based on the exclusion criteria, 868 articles in all were screened. Between 2004 and 2024, the quantity of articles published varied. Between 2017 and 2023, there was a consistent upward trend in the quantity of published literature. Cancer epidemiology biomarkers and prevention, cancers, and the Asian Pacific Journal of Cancer Prevention were the 3 journals with the most publications. The 2 nations with the most publications are China and the United States. The 2 nations with the most publications are China and the United States. The top 3 most published universities are Harvard University, the National Institutes of Health (NIH), and the National Cancer Institute (NCI). Buzzwords include body mass index, obesity, diabetes, smoking, and exercise.
    DOI:  https://doi.org/10.1097/MD.0000000000041831
  54. Int J Nanomedicine. 2025 ;20 3007-3030
    Research and Application Prospect of Nanomedicine in Kidney Disease: A Bibliometric Analysis From 2003 to 2024.
    Yilin Meng, Lu Sui, Tianhua Xu, Hainan Zhao, Quan Yuan, Li Sun.
      Kidney disease is a major public health concern that has a significant effect on a patient's life span and quality of life. However, effective treatment for most kidney diseases is lacking. Nanotechnology mainly explores the design, characterization, production, and applications of objects in the nanoscale range and has been widely used in the medical field. To date, there has been an increasing amount of research on the application of nanotechnology in kidney disease. However, systematic bibliometric studies remain rare. In this review, data collected from the Web of Science Core Collection database until December 31, 2024, were subjected to a bibliometric analysis. A total of 1179 articles and reviews were included. The publication trends, countries, institutions, authors, co-authorship, co-citations, journals, keywords, and references pertaining to this topic were examined. The results showed that nanotechnology research in kidney disease is increasing. The leading country, organization, and author were China, Sichuan University, and Professor Peng Huang, respectively. ACS APPLIED MATERIALS & INTERFACES was the top journal among the 464 journals in which articles on nanotechnology in kidney disease were published. KIDNEY INTERNATIONAL was the most cited journal in the field. The most significant increases were shown for "acute kidney disease", "drug delivery", "oxidative stress", "diabetic nephropathy", and "chronic kidney disease", indicating the current research hotspots. Furthermore, the development prospects and challenges of nanotechnology in kidney disease were discussed in this review. How to achieve precise drug delivery to render kidney-targeting therapy a reality may be problematic in future studies.
    Keywords:  bibliometric analysis; diagnosis; drug delivery; kidney disease; nanomedicine; therapy
    DOI:  https://doi.org/10.2147/IJN.S510016
  55. Medicine (Baltimore). 2025 Mar 14. 104(11): e41898
    Application of Mendelian randomized analysis method in Vitamin D research: A 10-year bibliometric analysis.
    Tai-Long Lv, Wen-Wen Li, Zhen-Hai Sun, Meng-He Zhang, Yao-Yao Zuo, Shu-Di Li, Yun-Xiao Zhang, Hui-Dan Xie, Shou-Qiang Chen.
      Vitamin D is an open-cyclic steroidal trace organic compound that plays a crucial role in human metabolism and nutritional health. In recent years, Mendelian randomization (MR) has emerged as a widely adopted method for analyzing causal relationships, particularly in studying the association between Vitamin D and related diseases. However, no bibliometric analyses have been conducted to explore the research hotspots and trends regarding Vitamin D status in MR studies. This study utilized the Web of Science Core Collection as a source database and retrieved articles on Vitamin D status in MR published from 2014 to 2024. Bibliometric and visualization analyses utilized VOSviewer, Microsoft Excel 2021, and Scimago Graphica. An in-depth analysis of country or region, authors, journals, keywords, and references were performed to provide insights into the content related to the field. A total of 186 documents authored by 1122 contributors across 30 countries were identified. China and the University of Bristol had the highest publication counts, with 94 and 19 articles, respectively. The nutrients published the largest number of articles, and J Brent Richards was the largest contributors. The most frequently used keywords included "Mendelian randomization," "Vitamin D," "25-hydroxyVitamin D," "obesity," and "Type 2 Diabetes." The current research focuses on using MR methods to explore the associations between Vitamin D status and metabolic, cardiovascular, immune skin, psychiatric and neurological diseases. The related research in this field will continue to increase in the next few years, which is a promising research prospect in this field. This study systematically reviews the literature from the past decade, revealing research hotspots and trends in the field of Vitamin D status within MR studies. This information will provide a strong reference for readers and researchers.
    DOI:  https://doi.org/10.1097/MD.0000000000041898
  56. Front Digit Health. 2025 ;7 1472753
    Global research landscape on nanotechnology in acute lung injury: a bibliometric analysis.
    Jian Zhang, Shasha Jiang, Jipeng Jiang, Yang Liu.
       Background: Acute lung injury is a common respiratory emergency that seriously affects the life, health and quality of life of patients, especially after the global COVID-19 pneumonia. The application of nanotechnology in acute lung injury is promising. In response to the knowledge explosion resulting from rapid publication growth, we applied bibliometric analysis to explore the research profile and thematic trends in the field.
    Methods: Articles and reviews related to nanotechnology in acute lung injury from 2004 to 2023 were searched. Java-based Citespace, VOSviewer, and R software-based Bibiometrix were used to systematically evaluate publications by spatiotemporal distribution, author distribution, subject categories, topic distribution, references, and keywords.
    Results: A total of 1,347 publications were included. The number of papers related to nanotechnology in acute lung injury has grown exponentially over the past 20 years. China was the most productive country out of all 53 countries, followed by the United States. The Chinese Academy of Sciences was the most productive institution with 76 papers. PARTICLE AND FIBRE TOXICOLOGY was the most productive journal. The top five high-frequency keywords were inflammation, oxidative stress, toxicity, in vitro, respiratory-distress-syndrome. And the top five emerging keywords were delivery, covid-19, extracellular vesicles, therapy, sars-cov-2. Drug delivery are the focus of current research. Two emerging research areas represented the development trends: novel nanocarriers with higher efficiency and lower biotoxicity, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
    Conclusion: The field of nanotechnology in acute lung injury has been in a period of rapid development in the last three years. Delivery,targeted delivery and exosm have been the focus of current research in this field. Two emerging research areas represented the development trends:novel nanocarriers with higher efficiency and lower biotoxicity such as extracellular vesicles, exosomes and solid lipid nanoparticles, and the other is research related to impact of nanomaterials in the progression of acute lung injury.
    Keywords:  acute lung injury; bibliometric analysis; drug delivery; nanotechnology; research trend
    DOI:  https://doi.org/10.3389/fdgth.2025.1472753
  57. Behav Sleep Med. 2025 Mar 21. 1-23
    Systematic bibliometric and visualized analysis of research hotspots and trends in obstructive sleep apnea neuroimaging.
    Bing Wen, Haijun Li, Xiang Liu, Yongqiang Shu, Dan Shen, Xinyi Bu, Dechang Peng, Yuting Liu, Lifeng Li.
       BACKGROUND: Obstructive sleep apnea (OSA) patients exhibit neurological symptoms, driving research in sleep medicine and clinical neurology. Neurologists and radiologists explore detection methods to identify unique neural features associated with OSA in the atypical nervous system. Neuroimaging research in OSA encompasses studying the structural, functional connectivity (FC), and neurometabolic aspects of the brain. Limited resources and OSA's heterogeneity pose challenges to effective neuroimaging research. This study aims to conduct a bibliometric analysis of OSA neuroimaging research to identify key trends and emerging themes.
    METHODS: This research utilizes various techniques, including functional MRI, structural MRI, diffusion tensor imaging, magnetic resonance spectroscopy, and electroencephalography, among others. Publications from 1993 to 2023 were retrieved from Web of Science on neuroimaging. Analysis tools included Bibliometric.com, CiteSpace, VOSviewer, and R4.3.2.
    RESULTS: A total of 714 papers were published in 47 countries, with 651 articles, 55 reviews, and 8 meeting abstracts. The USA led in publications, with the University of California System contributing most, primarily in "Sleep" journal. The study identified 2916 authors, with Macey PM having the highest publication count. Recent years highlighted burst keywords such as network, classification, sleep staging, FC, and brain activity. Analysis of keyword clusters revealed "electroencephalography" with the longest temporal duration.
    CONCLUSIONS: Neuroimaging in OSA research has gained increased attention. Incorporating behavioral sleep medicine insights could enhance understanding of OSA's impact on brain function and behavior. This study aims to assist researchers in identifying potential collaborators, institutions, and key themes, providing a comprehensive perspective on OSA neuroimaging research and related sleep disorders.
    DOI:  https://doi.org/10.1080/15402002.2025.2479795
  58. Front Med (Lausanne). 2025 ;12 1561619
    Lessons from the similarities and differences in fluid resuscitation between burns and sepsis: a bibliometric analysis.
    Dongxu Zhou, LuLu He, Wei Shi, Penglin Ma.
       Background: Fluid is an essential component of initial resuscitation in sepsis or burns. Meanwhile, the optimal strategy of titrating fluids for both of the two conditions remains uncertain. In this bibliometric analysis, we compared the similarities and differences in fluid resuscitation between sepsis and burns in recent publications.
    Methods: Literatures related to fluid resuscitation in either sepsis or burns were searched in the Web of Science database Core Collection from January 1, 1992, to December 31, 2022. CiteSpace and VOSviewer was used for bibliometric analysis.
    Results: A total of 1,549 and 468 publications on fluid resuscitation in sepsis and burns were retrieved from 1992 to 2022. Based on the occurrences, 341 and 86 high-frequency keywords were screened out from sepsis and burns publications, respectively, which were similarly categorized into 5 clusters [i.e. "mechanisms of hypovolemia" (cluster 1), "titration of fluid" (cluster 2), "outcomes or complications" (cluster 3), "pathophysiological alternations" (cluster 4), and "fluid types and others" (cluster 5)]. The high-frequency keywords of the top 20 were more concentrated in cluster 3 and cluster 2, with "mortality" ranked the top in both sepsis and burns literature. Significantly, 3 keywords in cluster 2 ranked in the top 5, including "goal directed resuscitation" (the 3rd), fluid responsiveness (the 4th) and fluid balance (the 5th) in sepsis literature, while the keywords of "microvascular exchange" (cluster 1) and "abdominal compartment syndrome" (ACS, cluster 3) ranked at the second and the fifth place in burns publications. Keyword burst analysis demonstrated that the keyword with the highest burst strength (BS) was "formula" (BS = 5.88, 2008-2014), followed by management (BS = 4.79, 2012-2022), ACS (BS = 4.76, 2006-2010), and fluid creep (BS = 4.74, 2011-2016) in burn publications, but they were dobutamine (BS = 12.31, 1992-2008), cardiac output (BS = 9.79, 1993-2001), catecholamine (BS = 9.54, 1993-2006), and consumption (BS = 7.52, 1992-2006) in sepsis literature. Moreover, the most frequently cited article in either sepsis or burns was categorized into cluster 2, that investigated goal-directed fluid therapy for sepsis and formula improvement for burns resuscitation.
    Conclusion: It was demonstrated that the research priorities in titrating fluid were mainly concentrated on targeting hemodynamics in sepsis vs. improving formula (which briefly calculates the increased microvascular permeability) in burns, while concerning of "outcomes and complications" in fluid resuscitation similarly after 1992. However, hemodynamics and microvascular permeability have been simultaneously well considered in few previous studies regarding fluid resuscitation in either sepsis or burns.
    Keywords:  bibliometric analysis; burn; complications; outcomes; resuscitation; sepsis
    DOI:  https://doi.org/10.3389/fmed.2025.1561619
  59. Sensors (Basel). 2025 Feb 26. pii: 1432. [Epub ahead of print]25(5):
    The Role of Virtual Reality on Parkinson's Disease Management: A Bibliometric and Content Analysis.
    Qiang Wu, Mengli Qiu, Xiaomei Liu, WanJiaAaron He, Ting Yang, Chengsen Jia.
      The management of Parkinson's disease (PD) has increasingly focused on innovative technologies, particularly virtual reality (VR), which has emerged as a significant tool for addressing neurological disorders. This bibliometric analysis summarizes current research trends and hotspots regarding VR applications in PD management. A comprehensive search of the Science Citation Index Expanded (SCIE) within the Web of Science Core Collection (WoSCC) identified 475 publications from 2000 to 2024. Key findings indicate a substantial increase in publication output, especially after 2013, driven by technological advancements and investments from major IT companies. Prominent research institutions and scholars from Australia, Israel, Italy, and Spain have led this field, exploring various VR applications for PD patients. The focus of VR therapy research has evolved from primarily addressing freezing of gait (FOG) to a broader range of functional impairments, including balance, postural control, upper limb motor, and cognitive function. This study provides valuable insights into the evolving landscape of clinical research on VR in PD management, highlighting global trends and potential areas for future investigation and application of VR therapies.
    Keywords:  Parkinson’s disease; bibliometric; hotspots; research trends; virtual reality
    DOI:  https://doi.org/10.3390/s25051432
  60. Medicine (Baltimore). 2025 Mar 14. 104(11): e41806
    Exploring the evolving frontiers of sleep deprivation research in the post-COVID-19 era.
    Siddig Ibrahim Abdelwahab, Manal Mohamed Elhassan Taha, Monira I Aldhahi, Ahmed Ali Jerah, Abdullah Farasani, Saleh Mohammad Abdullah, Ieman A Aljahdali, Roa Ibrahim, Omar Oraibi, Bassem Oraibi, Hassan Ahmad Alfaifi, Amal Hamdan Alzahrani, Yasir Osman Hassan Babiker.
      Sleep deprivation research (SDR) has undergone substantial transformations in the aftermath of the COVID-19 pandemic. This comprehensive study explores the SDR's evolving trends, hotspots, and conceptual structure in the post-COVID-19 era. Using bibliometric analysis with VOSviewer and Bibliometrix software, we examined the SDR publications from January 2020 to December 2023. Core sources were identified using Bradford law, and a dataset of 4578 English-based data-driven studies was retrieved from the Scopus database. Our analysis revealed a remarkable annual growth rate of 37.92% in SDR from 2020 to 2023, indicating a heightened research focus in this domain. Among prolific authors, Shao emerged as a key contributor, while Sleep ranked prominently as a leading publication venue. The United States and China have emerged as the most impactful countries for advancing SDR research. Uncovering the most cited documents sheds light on various focal points within SDR, including sleep duration, mental health implications, cardiovascular events, the impact of COVID-19 on sleep patterns, dementia, resilience in children, and sleep patterns among preschoolers. Noteworthy keywords that emerged from the analysis encompassed "sleep deprivation," "depression," "insomnia," "COVID-19," "anxiety," "fatigue," and "obesity." Using a thematic mapping approach, we delineated distinct themes characterized by niche, basic, emerging, and declining patterns. Clusters of SDR research were observed in areas such as "Fatigue," "Sleep apnea," "Sleep," "Sleep deprivation," "Migraine," "Caffeine," and "Recovery." Furthermore, trending themes in SDR encompassed "Sleep disturbance," "excessive daytime sleepiness," and "Gamma-Aminobutyric Acid." These comprehensive findings provide valuable insights into the current landscape of SDR, illuminating emerging trends, identifying hotspots, and offering directions for future research in this critical field.
    DOI:  https://doi.org/10.1097/MD.0000000000041806
  61. Front Sociol. 2025 ;10 1502700
    Research theme mapping and future directions on corruption and religion: a bibliometric analysis.
    Salahudin, Iradhad Taqwa Sihidi, Ali Roziqin, Tinuk Dwi Cahyani, Kisman Karinda, Muhammad Firdaus, Tawakkal Baharuddin.
      Corruption harms social and economic structures whilst religion acts as a moral pillar with ethical values to fight it. Unfortunately, the relationship between the two is less explored in the literature. This present study employs a bibliometric analysis approach with data retrieved from the Scopus database. We explore the relationship between corruption and religion through the identification of trends and mapping important topics to reveal potential future research on the topic. The results show a considerable increase in the recent number of publications on the topic despite its limited literature. More importantly, the mapping illustrates that the relationship between corruption and religion has transformed focus from economic, social, and political factors to including religious variables as an important element. In particular, topics like religiosity, religious affiliation, liberation theology, education, and anti-corruption mark shifts in complexity in current discussions. Such a complexity challenges diverse perceptions of religious values and their position in linking political and economic interests. This finding implies that future research needs to adopt a holistic and contextual framework to understand the factual impact of religion on corruption. This attempt potentially expands the current thinking on the role of religion within corruption cases in shaping a more inclusive perspective that bridges anti-corruption practises in society.
    Keywords:  anti-corruption; corruption; liberation theology; religion; religiosity
    DOI:  https://doi.org/10.3389/fsoc.2025.1502700
  62. Front Immunol. 2025 ;16 1508909
    Current perspectives and trends of neutrophil extracellular traps in organ fibrosis: a bibliometric and visualization study.
    Yanbo Li, Zhengmin Cao, Jing Liu, Rui Qiang, Jiuchong Wang, Wenliang Lyu.
      New insights into the role of immune responses in the fibrosis process provide valuable considerations for the treatment of organ fibrotic diseases. Neutrophil extracellular traps (NETs) represent a novel understanding of neutrophil functions, and their involvement in organ fibrotic diseases has garnered widespread attention in recent years. This study aims to conduct a bibliometric analysis and literature review focusing on the mechanisms by which NETs participate in fibrotic diseases. Specifically, we utilized a bibliometric dataset that includes 220 papers published in 139 journals, originating from 425 organizations across 39 countries, with a total citation count of 12,301. Keyword co-occurrence analysis indicates that the research focus on the mechanisms of NETs in organ fibrosis is likely to center on NETosis, immune responses, immune thrombosis, inflammation, and tissue damage associated with NET formation. In conclusion, our findings underscore the current status and emerging trends in NET research related to organ fibrosis, offering novel insights into the mechanisms by which NETs contribute to the pathogenesis of fibrotic diseases, as well as potential therapeutic strategies.
    Keywords:  bibliometrics; immune response; neutrophil; neutrophil extracellular traps; organ fibrosis; visualization
    DOI:  https://doi.org/10.3389/fimmu.2025.1508909
  63. Health Econ Rev. 2025 Mar 18. 15(1): 24
    Measuring productivity in the healthcare sector: a bibliometric and content analysis.
    Ionela-Andreea Puiu, Abigaela Bîlbîie.
       BACKGROUND: Productivity in the healthcare sector has evolved as an appealing research topic in the last few years. Despite the growing interest, the extant scientific literature mostly concentrates on methodologies rather than theoretical and practical insights. Although diverse methodologies provide valuable quantitative wisdom, their application is often misaligned with broader economic theories or healthcare purposes, limiting their contribution to advancing theoretical and practical understanding of efficiency and productivity in healthcare systems. In this respect, the current study endeavors to bridge the research gap concerning the lack of a comprehensive overview of productivity measurements in the healthcare sector.
    METHODS: We investigate this concern through a bibliometric and content analysis of articles published on healthcare productivity measurement techniques in the Web of Science database between 2003 and 2023. We provide a quantitative and critical analysis of conceptualization, methods, findings, and implications of the selected published articles concerning productivity measurements in the healthcare sector.
    RESULTS: Our research discovered that the sanitary crisis generated by COVID-19 boosted the publication of scientific papers on productivity measurements in healthcare, with Europe emerging as a leading region in publication output. Although Data Envelopment Analysis and the Malmquist Index monopolize the range of measurement techniques used to quantify productivity, current research highlights the requirement for alternative methodologies to grasp the multidimensionality of healthcare productivity, including its interaction with quality and technological progress.
    CONCLUSIONS: We raise awareness that future efforts should prioritize multidimensional and context-sensitive approaches to measuring healthcare productivity, balancing efficiency, technological progress, and quality of care. Policymakers should focus on designing context-specific policies tailored to regional challenges and promoting targeted research funding to explore underrepresented areas of healthcare services.
    Keywords:  Bibliometric analysis; Content analysis; Healthcare; Productivity
    DOI:  https://doi.org/10.1186/s13561-025-00612-z
  64. Rev Lat Am Enfermagem. 2025 ;pii: S0104-11692025000100321. [Epub ahead of print]33 e4422
    Virtual simulation in nursing education in Latin America and the Caribbean: A bibliometric study.
    Agostinho A C Araújo, Lucas Gardim, Sara Soares Dos Santos, Ítalo Rodolfo Silva, Manoel Carlos Neri da Silva, Simone de Godoy, Isabel Amélia Costa Mendes.
       BACKGROUND: 1) Virtual simulation connects theory and practice in nursing education.(2) Only Brazil, Chile, Colombia, and Cuba conducted research on the subject. (3) Brazilian journals lead scientific production on virtual simulation. (4) Scientific production on the subject has increased.
    OBJECTIVE: to examine the characteristics of scientific production in Latin America and the Caribbean regarding virtual simulation in nursing education.
    METHOD: a bibliometric study conducted in five stages: research design, compiling the bibliometric data, analysis, visualization, and interpretation; and based on the recommendations of the Preferred Reporting Items for Bibliometric Analysis (PRIBA). The search was conducted in the Latin American and Caribbean Health Sciences Literature (LILACS). VOSviewer version 1.6.20 was used for bibliometric analysis. Bradford's and Zipf's Laws were applied to interpret the data, considering the temporal dynamics of publications, an analytical approach to the structure of the selected studies and their repercussions in virtual simulation in nursing education in Latin America and the Caribbean.
    RESULTS: 579 studies were identified, of which 46 were included in the final sample. The studies included were published between 1994 and 2022, and only Brazil, Chile, Colombia, and Cuba conducted research related to virtual simulation. The semantic map resulted in five clusters, highlighting "simulation training" as the most important term.
    CONCLUSION: our findings suggest a projected increase in Scholarly publications on virtual simulation in nursing education in Latin America and the Caribbean in the coming years.
    DOI:  https://doi.org/10.1590/1518-8345.7261.4422
  65. Front Oncol. 2025 ;15 1509457
    Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.
    Yanhong Pei, Haijie Liang, Yu Guo, Boyang Wang, Han Wu, Zhijian Jin, Shanyi Lin, Fanwei Zeng, Yifan Wu, Qianyu Shi, Jiuhui Xu, Yi Huang, Tingting Ren, Jiarui Liu, Wei Guo.
       Background: Liquid-liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions. However, a comprehensive bibliometric analysis on LLPS and immune signaling processes in cancer is still scarce. This study aims to perform a bibliometric assessment of research to explore the landscape of LLPS research in immune signaling pathways for cancer.
    Methods: Utilizing the Web of Science Core Collection database and multiple analysis software, we performed quantitative and qualitative analyses of the study situation between LLPS and immune signaling in cancer from 1992 to 2024.
    Results: The corresponding authors were primarily from China and the USA. The most relevant references were the "International Journal of Molecular Sciences", "Proteomics". The annual number of publications exhibited a fast upward tendency from 2020 to 2024. The most frequent key terms included expression, separation, activation, immunotherapy, and mechanisms. Qualitative evaluation emphasized the TCR, BCR, cGAS-STING, RIG-1, NF-κB signaling pathways associated with LLPS processes.
    Conclusion: This research is the first to integratively map out the knowledge structure and forward direction in the area of immune transduction linked with LLPS over the past 30 years. In summary, although this research area is still in its infancy, illustrating the coordinated structures and communications between cancer and immune signaling with LLPS within a spatial framework will offer deeper insights into the molecular mechanisms of cancer development and further enhance the effectiveness of existing immunotherapies.
    Keywords:  CiteSpace; bibliometric; cancer; immune transduction; liquid liquid phase separation (LLPS)
    DOI:  https://doi.org/10.3389/fonc.2025.1509457
  66. Aesthetic Plast Surg. 2025 Mar 20.
    Mapping the Global Research Landscape: A Bibliometric Analysis of Clinical Trials on Skin Aging-Trends, Innovations, and Research Gaps.
    Sa'ed H Zyoud, Tauseef Ahmad, Samah W Al-Jabi.
      Skin aging is a multifaceted biological process influenced by both intrinsic and extrinsic factors. It involves changes at the tissue, cellular, and molecular levels. Recently, clinical trials have provided growing evidence across various aspects of skin aging. This study provides a thorough analysis of scientific publications on clinical trials related to skin aging. It includes publications indexed in the Scopus database between 2005 and 2024, retrieved using a wide array of pertinent keywords. Following this, network analysis and visualization were performed with VOSviewer (v. 1.6.20) to map research trends and pinpoint emerging research hotspots. From 2005 to 2024, 550 publications investigated the relationship between clinical trials and skin aging. Over the past two decades, the number of publications in this field has increased significantly (R2 = 0.9346; p < 0.001), from seven in 2005 to 93 in 2024. This growth can be divided into two phases: a gradual increase from 2005 to 2015, followed by a period of rapid expansion from 2016 to 2024. The United States leads with 128 publications, representing 23.27% of the total. South Korea ranks second with 81 publications (14.73%), China ranks third with 54 publications (9.82%), and Italy ranks fourth with 49 publications (8.91%). Recent studies have concentrated on several key areas, including "topical anti-aging treatments and nutraceuticals," "patient safety and satisfaction in laser and light-based therapies, with a focus on adverse effects and clinical trial findings," and "clinical trials examining oral supplements for skin wrinkling and aging." This analysis underscores the pressing need for ongoing research and collaboration to enhance patient outcomes and the efficacy of anti-aging treatments, especially those involving topical treatments, nutraceuticals, and oral supplements.Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .
    Keywords:  Bibliometric; Clinical trials; RCT; Skin aging
    DOI:  https://doi.org/10.1007/s00266-025-04823-x
  67. RSC Adv. 2025 Mar 06. 15(10): 8072-8087
    Application and development of sludge-based materials for environmental pollution remediation: a bibliometric review from 2004 to 2024.
    Fangyuan Jin, Jinxia Lu, Fei Sun, Fang Yang, Zhonghong Li.
      In recent years, considerable attention has been directed towards the development of high-value materials derived from various types of sewage sludge (SS) including adsorbents, catalysts, and soil amendments, for their potential in environmental pollution remediation. To investigate the current research status, hotspots, and development trends of sludge-based materials for environmental pollution remediation, this study adopted bibliometric tools, such as Bibliometrix, VOSviewer, and Citespace, to conduct a quantitative analysis of the related literature published between 2004 and 2024, collected from the Web of Science Core Collection (WOSCC) database. The results indicated a consistent annual increase in publication numbers, with a marked acceleration observed over the past six years. China significantly outperforms other countries in terms of publication quantity and institutions, and forming a country cooperation network centered around China. Keyword co-occurrence and burst analyses revealed that the current research hotspots in the field of sludge-based materials for environmental pollution remediation primarily focused on the preparation methods, particularly pyrolysis, and the performance and mechanisms studies of the sludge-based materials as adsorbents and catalysts. Future research should prioritize exploring modification methods and materials to develop further high-performance sludge-based materials, such as sludge-based electrode materials. Moreover, in-depth investigations into the impacts of sludge-based soil amendments on soil physical, chemical, and biological properties should be emphasized. By utilizing bibliometrics to evaluate the current state and future trends of sludge-based materials for environmental pollution remediation, this article provides valuable insights into the field's evolution for researchers.
    DOI:  https://doi.org/10.1039/d5ra00620a
  68. Front Microbiol. 2025 ;16 1500893
    The worldview of Akkermansia muciniphila, a bibliometric analysis.
    Zhao Zhang, Jingyu Wang, Shaoqing Dang, Xingzi Liu, Yuemiao Zhang, Hong Zhang.
      Akkermansia muciniphila (A. muciniphila), a critical bacterium within the gut microbiota, plays a key role in human health and immunomodulation. Since its identification in 2004, A. muciniphila has emerged as a significant agent in treating metabolic diseases, gastroenterological diseases, and tumor immunotherapy. Its rapid ascent in scientific translation underscores its importance in gut microbiome research. However, there has been a lack of visualization and analysis of the rapidly occurring commercialization in this field, which has critically hindered insights into the current knowledge structure and understanding of the cutting-edge of the discipline. This study employs the Web of Science Core Collection (WOSCC) and Innography platforms to provide the first comprehensive analysis of A. muciniphila's academic progresses and commercialization over the past two decades, highlighting its growing prominence in global health research. Our analysis delineates that, following the academic trajectory, the evolution of A. muciniphila patents from foundational research through to application development and maturity, with particular emphasis on its expansive potential in emerging fields, including gastroenterological disorders, non-alcoholic fatty liver disease, cancer immunotherapy, stress management, and neurodegenerative disease treatment. Concluding, A. muciniphila presents as a next-generation probiotic with vast implications for human health. Our findings provide essential insights for future research and product development, contributing to the advancement of this burgeoning field.
    Keywords:  Akkermansia muciniphila; Innography; bibliometric analysis; patent transformation; probiotics; research progress; therapeutic potential
    DOI:  https://doi.org/10.3389/fmicb.2025.1500893
  69. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025 Jan 20. 56(1): 166-174
    [Benchmarking China's Top-Tier Medical Institutions Against Global Standards: A Quantitative Analysis of the Gap Using Internationally Recognized Metrics].
    Gui Yang, Yajuan Cui, Rui Dai, Qiuqiu Zhang, Wenqi Luo.
       Objective: To evaluate the gap between China's top-tier medical institutions and top-tier international medical institutions, and to provide references for the construction of first-class medical science discipline in China.
    Methods: Using globally recognized rankings of medical institutions, we selected 24 top-tier international medical institutions and 11 top-tier Chinese medical institutions. Publicly available, general, and comparable data on indicators were collected to analyze the performance and gaps between top-tier international and Chinese medical institutions in human resources development, talent cultivation, scientific research, social services, and discipline construction.
    Results: In the field of medicine, the largest gap between top-tier international and Chinese medical institutions was in high-level talent. Specifically, the average numbers of individuals who are Clarivate Analytics' Highly Cited Researchers, who are Nobel Prize laureates in Physiology or Medicine, and who serve on advisory boards or editorial boards of top medical journals, and who rank among the Top 2 000 Medicine Scientists were 1.00, 0.09, 0.45 and 4.00, respectively, among top-tier Chinese medical institutions, while those of the top-tier international medical institutions were 131.46, 118.25, 9.72, and 6.76 times, respectively, those of the Chinese medical institutions. The second largest gap was in social services and medical innovation. The average proportion of industrial collaboration papers and the number of clinical trials of China's top-tier medical institutions were 1.51% and 1 851, respectively, while those of international top-tier medical institutions were 3.62 and 1.87, times, respectively, those of top-tier Chinese medical institutions. However, the average number of (untranslated) patents held by top-tier international medical institutions was only 15% of that of China's top-tier medical institutions.The third largest gap was in scientific research. The average number of papers published in New England Journal of Medicine, Journal of the American Medical Association, The Lancet, and British Medical Journal, the percentage of hot papers in papers included in Web of Science, the percentage of highly cited papers, the percentage of international collaboration papers, the total number of citations per paper, category normalized citation impact (CNCI), and the number of publications of top-tier Chinese medical institutions were 78, 0.03%, 1.39%, 22.55%, 19.61, 1.26, 30 706, while those of the top-tier international medical institutions were 6.96, 2.66, 2.57, 2.15, 1.83, 1.58 and 1.54 times those of the Chinese medical institutions, respectively. However the average percentage of zero-citation papers of top-tier international medical institutions was only 71% of that of China's top-tier medical institutions. Furthermore, in discipline development, the average overall scores of the Times Higher Education (THE) and QS rankings for medicine-related disciplines of top-tier Chinese medical institutions were 72.84 and 69.30, respectively, while those of top-tier international medical institutions were 1.38 and 1.21 times those of the Chinese medical institutions. However, in terms of talent cultivation, the average number of students of China's top-tier medical institutions was 10724, which is roughly double that of international institutions.
    Conclusion: Currently, China's top-tier medical institutions are still in a basic stage that emphasizes the quality of talent cultivation and medical services. There is considerable room for development and potential for catching up in multiple aspects, especially in high-level talent, medical research, and innovation. It is recommended that the construction experience of top-tier international medical institutions should be fully utilized to build China's first-class medical science discipline.
    Keywords:  International comparison; Medical level; Quantitative analysis; Subject evaluation
    DOI:  https://doi.org/10.12182/20250160302
  70. Front Med (Lausanne). 2025 ;12 1553970
    A bibliometric analysis of artificial intelligence research in critical illness: a quantitative approach and visualization study.
    Zixin Luo, Jialian Lv, Kang Zou.
       Background: Critical illness medicine faces challenges such as high data complexity, large individual differences, and rapid changes in conditions. Artificial Intelligence (AI) technology, especially machine learning and deep learning, offers new possibilities for addressing these issues. By analyzing large amounts of patient data, AI can help identify diseases earlier, predict disease progression, and support clinical decision-making.
    Methods: In this study, scientific literature databases such as Web of Science were searched, and bibliometric methods along with visualization tools R-bibliometrix, VOSviewer 1.6.19, and CiteSpace 6.2.R4 were used to perform a visual analysis of the retrieved data.
    Results: This study analyzed 900 articles from 6,653 authors in 82 countries between 2005 and 2024. The United States is a major contributor in this field, with Harvard University having the highest betweenness centrality. Noseworthy PA is a core author in this field, and Frontiers in Cardiovascular Medicine and Diagnostics lead other journals in terms of the number of publications. Artificial Intelligence has tremendous potential in the identification and management of heart failure and sepsis.
    Conclusion: The application of AI in critical illness holds great potential, particularly in enhancing diagnostic accuracy, personalized treatment, and clinical decision support. However, to achieve widespread application of AI technology in clinical practice, challenges such as data privacy, model interpretability, and ethical issues need to be addressed. Future research should focus on the transparency, interpretability, and clinical validation of AI models to ensure their effectiveness and safety in critical illness.
    Keywords:  CiteSpace; VOSviewer; artificial intelligence; bibliometric; critical illness
    DOI:  https://doi.org/10.3389/fmed.2025.1553970
  71. Ann Med Surg (Lond). 2025 Feb;87(2): 1078-1079
    Commentary on "The recent two decades of traumatic brain injury: a bibliometric analysis and systematic review".
    Zengkun Fang, Pengke Pan.
      
    DOI:  https://doi.org/10.1097/MS9.0000000000002811
  72. Ann Vasc Surg. 2025 Mar 14. pii: S0890-5096(25)00118-9. [Epub ahead of print]
    African Research Output Within the Top 5 Vascular Surgery Journals.
    Oluwatobi Shekoni, Tioluwanimi Ojeola, Oduwale Mubaraq, Adebayo Falola.
       BACKGROUND: With Africa's population growth and an epidemiological shift from communicable to non-communicable diseases, there is an urgent need to expand vascular surgery capacity across the continent. Despite a high disease burden, Sub-Saharan Africa contributes less than 1% of the global surgical research, with significant challenges in surgical infrastructure, access to consumables, and limited research output. This study assesses the publication output of African authors in the top five vascular surgery journals and explores trends in African vascular research.
    METHODS: The top five vascular surgery journals, based on CiteScore-impact factor, were selected: Journal of Vascular Surgery (JVS), European Journal of Vascular and Endovascular Surgery (EJVES), Journal of Vascular Surgery: Venous and Lymphatic Disorders (JVS-VL), Annals of Vascular Surgery (AVS), and Journal of Endovascular Therapy (JEVT). A PubMed search identified articles authored by researchers affiliated with African institutions. After removing duplicates and exclusions, 252 articles were analyzed using SPSS v27.0.1.
    RESULTS: AVS and JVS were the most frequent publication venues, accounting for 32.5% and 28.6% of articles, respectively. Egypt and South Africa were the leading contributors, producing 44.8% and 28.2% of the research, respectively. Most studies were observational (81.3%), with only 7.1% being interventional. Research output has steadily increased, with 38.1% of articles published in the 2010s and 36.5% in the 2020s.
    CONCLUSION: Vascular surgery is an emerging specialty in Africa, facing challenges, particularly in research. However, the number of publications in leading vascular surgery journals by African researchers is increasing, with Egypt and South Africa leading the way. More efforts are needed to enhance access to vascular surgery and research in Africa to boost the continent's contribution to global vascular surgery literature.
    Keywords:  Africa; Publication; Research; Vascular journal; Vascular surgery
    DOI:  https://doi.org/10.1016/j.avsg.2025.02.017
  73. Front Oncol. 2025 ;15 1481406
    The top 100 papers on prostate cancer-associated exosomes on social media: an altmetric study from the MENA region.
    Nasim Ansari, Faezeh Zaeri Basir, Mina Mahami-Oskouei, Roya Rashti, Ali Ouchi.
       Purpose: This altmetric analysis aimed to identify and describe the top 100 papers on prostate cancer-associated exosomes in the Middle East and North Africa (MENA) region cited on social media.
    Design/methodology/approach: As an applied study with an altmetric approach, this research included all Science Citation Index (SCI) Expanded indexed papers on prostate cancer-associated exosomes in the MENA region during 1970-2023. Altmetric Attention Scores (AASs) were extracted from the Altmetric Explorer, and Excel and SPSS were used for data analysis.
    Finding: Twitter ranked first in mentioning 73.55 of the top 100 studied papers. The highest score of mentions on Twitter equaled 187, and that of AAS was 516, which belonged to an original research article. However, the top paper in citation counts was a guideline (AAS = 116; citation count = 5,664 =). The Journal of Urology published most papers (n = 21), with total AAS = 1,094. Most papers were international collaborations (n = 82). There was no significant relationship between the AASs of papers and those of Web of Science (WoS) citation counts (R2 = 0.1284, p-value = 0.2054).
    Practical implications: Showing a broad perspective on the research priorities and new directions in prostate cancer-associated exosomes, this study can be a guideline for finding main papers on diagnosing, treating, and preventing prostate cancer. It helps researchers, professionals, and policymakers in developing the use of social media in disseminating related information.
    Originality: By providing helpful information on prostate cancer-associated exosomes, this study can inform researchers and administrators of the state of research on the topic and consequent health promotion among the public.
    Keywords:  MENA region; altmetric study; exosome; prostate cancer; social media
    DOI:  https://doi.org/10.3389/fonc.2025.1481406
  74. Front Med (Lausanne). 2024 ;11 1433193
    Bibliometric-based visualization analysis of hotspots and trends in falls research among older hospitalized patients (2013-2023).
    Yang Dong, Dandan Liu, Ya Yu, Ziyu Xiong, Hongying Rao.
       Purpose: We utilized Citespace 6.2 R4 software to visualize and analyze the literature published within the past decade (2013-2023) pertaining to falls in elderly hospitalized patients, with the objective of examining the progression and patterns of focal points within this research domain. Our aim is to offer a valuable reference and foundation for related studies and to provide guidance for healthcare professionals and researchers in advancing further exploration and implementation of strategies for preventing and managing falls in elderly patients.
    Methods: We conducted a literature search in the Web of Science database using keywords such as "older hospitalized patients" and "fall" to develop a search strategy that was highly relevant to the topic of falls among older hospitalized patients. We further limited the literature time range to January 1, 2013, to December 31, 2023, to capture the latest research trends over the past decade. In terms of literature type, we focused on "article" and excluded conference papers, reviews, editorials, etc., to ensure the scientific rigor and reliability of the study. During the screening process, we excluded duplicate publications and those documents that were not directly related to falls among older hospitalized patients, such as those primarily discussing falls in other age groups or non-hospital environments. Although our search had no language restrictions, we only included English-language literature to ensure consistency and readability of the language. Additionally, we evaluated the quality of the literature and excluded those with unclear research methods or unreliable results to ensure the reliability of the research findings. Subsequently, we utilized CiteSpace 6.2 R4 software to generate a knowledge map for visualization and analysis.
    Results: Our analysis included a total of 321 articles. The results showed that the majority of contributions in this field came from the United States and China, both of which exhibited an intermediary centrality >0.1, indicating their significant influence. Harvard University became the leading institution with the most published articles (n = 8), while Imagama was identified as the most prolific author (n = 6). Moving forward, combining keywords with the strongest citation bursts, it is expected that the research trends in this field in the future will focus on epidemiology, aging, and health-related topics.
    Conclusion: Our study presents a comprehensive investigation into the evolution and trends of research focal points regarding falls in elderly hospitalized patients from 2013 to 2023. Our findings reveal a significant increase in attention toward this research area over the past decade, with a growing number of studies being conducted. Fall risk assessment, prevention strategies, rehabilitation interventions, and costs associated with falls have emerged as the primary research focal points within this field. Furthermore, epidemiology, aging population dynamics, and health outcomes continue to be enduring areas of interest for researchers post-2018 and warrant additional emphasis from scholars.
    Keywords:  bibliometrics; fall; older hospitalized patients; research hotspots; visualization analysis
    DOI:  https://doi.org/10.3389/fmed.2024.1433193
  75. J Chin Med Assoc. 2025 Mar 17.
    Cancer publications using real-world data from the Taiwan National Health Insurance Research Database: conceptual framework and bibliometric analysis.
    Wing Hin Stanford Siu, Ai Yin Lim, Jia-Rou Liu, Shu-Hao Chang, Wei-Min Chen, Pei-Ru Li, Lai-Chu See.
       BACKGROUND: Bibliometric analysis often overlooks study-based components such as study aims, design, and statistical methods. In this study, we propose a conceptual framework incorporating these study-based components with disease-based components for the bibliometric analysis of cancer articles using real-world data. This framework is a significant step forward in cancer research. We then investigated the distribution and temporal trends of these components for cancer articles using the Taiwan National Health Insurance Research Database (NHIRD) published from 2006 to 2022.
    METHODS: Study- and disease-based components were extracted and cross-validated. The distribution and temporal trends of these components were then presented.
    RESULTS: We analyzed 1232 articles and found a noticeable increase in the annual publication count from 2011 onward. This upward trend signified the growing momentum in cancer research. Cancer risk factors were the most studied (52%), followed by cancer outcomes (36%) and incidence/prevalence (3%). Among the publications on risk factors and outcomes, most were cohort studies (85%), followed by case-control studies (10.7%). In both study designs, the use of the propensity score method increased steadily from 2.4% in 2011 to 40% in 2022. The most frequently studied cancer site was 'all cancers or multiple cancers' (25.6%), followed by breast (9.6%), hepatobiliary (9.2%), and colorectal cancers (8.8%). Among the top 10 cited articles, the first and fourth focused on whether suppressing hepatitis B viral load with nucleoside analogs could reduce hepatocellular carcinoma recurrence and incidence in chronic hepatitis B patients. The remaining eight examined the association between medications and cancer risk.
    CONCLUSION: Beyond citation metrics, our research underscores the importance of considering study-based and disease-based components in bibliometric analysis. These components form the foundation of the real-world data cancer research framework and have practical implications for diseases beyond cancers, providing a broader perspective for researchers and practitioners.
    DOI:  https://doi.org/10.1097/JCMA.0000000000001227
  76. Arq Neuropsiquiatr. 2025 Mar;83(3): 1-8
    Arquivos de Neuro-Psiquiatria, 80 years: part 1 (1943-1962).
    Rodrigo Fagundes da Rosa, Francisco Duque de Paiva Giudice Junior, Francisco de Assis Aquino Gondim.
       BACKGROUND:  Arquivos de Neuro-Psiquiatria (ANP), the official journal of Academia Brasileira de Neurologia (ABN, Brazilian Academy of Neurology), celebrated 80 years in 2023.
    OBJECTIVE:  To analyze the publication trends, authorship, and editorial patterns of the first 20 volumes of ANP.
    METHODS:  We analyzed the first 20 volumes of ANP, published from 1943 to 1962. The data were tabulated independently by two blinded researchers and cross-verified.
    RESULTS:  Oswaldo Lange was the chief editor, and, from 1943 to 1962, 20 volumes, 79 issues, 2 supplements, and 885 articles were published. We analyzed 509 articles (and excluded non-research papers). We found 905 authors (1.78 authors/article), and only 3.75% were women. Horacio Martins Canelas, Rolando Ângelo Tenuto, and Paulo Pinto Pupo were the most prolific authors. There were 326 papers on neurology, 83 on neurosurgery, 88 on psychiatry, and 12 on basic research. A comparison between the first 10 and second 10 volumes disclosed a significant difference in the fields of the articles: a progressive decrease in papers on psychiatry and an increase in those on neurology and basic science (p = 0.005). There was also a significant decrease in the total number of published articles in the second 10 volumes (p = 0.001), and a higher number of citations per article (p = 0.014), but no difference in the number of pages (mean number in the original articles: 11.9 ± 6.7 pages). Although most articles came from Southeastern Brazil (74%) and were written in Portuguese (84%), 91 were foreign.
    CONCLUSION:  The first 20 volumes marked the establishment of ANP in the post-World War II era. Most papers were written in Portuguese and included international contributions from Egas Moniz, Barraquer-Bordas, Bing, Denny-Brown and Wartenberg, for example.
    DOI:  https://doi.org/10.1055/s-0045-1804917
  77. Int Orthop. 2025 Mar 18.
    International medical graduate orthopaedic residents show higher research productivity than United States graduate peers before and during residency.
    James S MacLeod, Freddy Jacome, Hadel Mansour, Michael S Lee, Frances Akwuole, Sia Cho, Justin Lee, Owen Lema, Avani Chopra, Yianni Bakaes, Sabrina Painter, Hayden Baker, Alfonso Mejia.
       PURPOSE: International Medical Graduates (IMGs) have lower match rates than their United States (U.S.)-trained Doctor of Allopathic Medicine (MD) and Doctor of Osteopathic Medicine (DO) peers. This study aims to more completely elucidate the research accomplishments required for IMGs to match into orthopaedic residency and to compare their academic productivity during residency to that of U.S. MD and DO graduates.
    METHODS: Data from orthopaedic-related journals and ACGME-accredited residency programs were extracted in July of 2024 using Python. Variables included: residency year, publications, first-author publications, citations, journals, h-index, medical school type, and the medical school and residency program locations.
    RESULTS: Prior to residency, the 56 matched IMGs had a mean of 32.8 publications, 9.8 first-author publications, and 517.1 citations. Matched U.S. MDs had an average of 3.7 publications, 1.1 first-author publications, and 61.0 citations while DO matched applicants had an average of 3.7 publications, 1.0 first-author publications, and 5.6 citations. During residency, IMG orthopaedic residents averaged 5.2 publications per year and 16.6 citations per year. U.S. MD residents averaged 1.3 publications per year and 3.6 citations per year, while DO residents averaged 0.55 publications per year and 1.1 citations per year. The h-index averaged 9.8 for IMGs, 2.2 for U.S. MDs and 0.7 for DOs. All comparisons for IMGs vs. U.S. MDs and IMGs vs. DOs yielded P < 0.0001.
    CONCLUSION: These findings highlight the significant differences in research output between IMGs and their U.S.-trained counterparts in orthopaedic surgery, and show that these differences continue throughout residency.
    Keywords:  Education; IMG; International; Orthopaedic surgery; Publication; Research; Training
    DOI:  https://doi.org/10.1007/s00264-025-06488-2
  78. Otolaryngol Head Neck Surg. 2025 Mar 19.
    Disclosure of Industry Relationships by Otolaryngologists.
    Madeline M Nottoli, Cynthia Tsang, Zoe Hsiao, Arjun Sharma, Sina J Torabi, Khodayar Goshtasbi, Sunil P Verma, William B Armstrong, Yarah M Haidar, Tjoson Tjoa, Harrison W Lin, Edward C Kuan.
       OBJECTIVE: This study aims to characterize how often otolaryngologists disclose relevant industry payments in publications and identify characteristics of these industry relationships.
    STUDY DESIGN: A cross-sectional database and bibliometric analysis.
    SETTING: Open Payments Database and PubMed.
    METHODS: Publications by the 10 highest-compensated otolaryngologists from each of 12 representative medical device and drug companies from 2018 to 2020 were assessed for disclosure of potential conflicts of interest in the years following payment through 2023.
    RESULTS: After excluding 52 physicians who did not publish in this period, 102 individuals received a combined $8,473,091.68, with an individual median of 15 payments (interquartile range [IQR] = 47) and median compensation of $18,522.77 (IQR = $53,965.52) from 1 or more of the 12 companies analyzed. The median number of publications per author was 10 (IQR = 25), and the median h-index of the authors was 16 (IQR = 28). Of the 1735 publications, 114 were classified as relevant, either because the study involved the evaluation of a device manufactured by one of the analyzed companies or because one of the companies funded the study. Of these, 23 (20.1%) were missing personal disclosure by the author. Of the physicians analyzed, the most represented subspecialty was rhinology (n = 47, 31%) followed by otology (n = 18, 11.8%).
    CONCLUSION: Although most publications in the years following payments from device companies were not deemed to have potential conflicts of interest, a notable proportion of those with authors who received payments lacked relevant financial disclosure. As transparency of relevant industry relationships has received increased attention, appropriate disclosure is recommended.
    Keywords:  Sunshine Act; conflict of interest; industry relationships; otolaryngology; publications
    DOI:  https://doi.org/10.1002/ohn.1223
  79. J Ethnopharmacol. 2025 Mar 15. pii: S0378-8741(25)00280-6. [Epub ahead of print] 119596
    Corrigendum to "Emerging insights into traditional Chinese medicine associated with neurodegenerative diseases: A bibliometric analysis" [J. Ethnopharmacol. 337 (2025) 118785].
    Yijie Luo, Boqi Hu, Zhenjun Yuan, Houjia Bi, Jiaqi Yu, Qian Pan.
      
    DOI:  https://doi.org/10.1016/j.jep.2025.119596
  80. Ann Med Surg (Lond). 2025 Jan;87(1): 217-223
    Worldwide research tendency and collaborations on models of necrotizing enterocolitis: bibliometric exploration over the past three decades.
    Boshen Shu, Shufeng Zhang, Jian Gao, Lin Wang, Xiaohui Wang.
       Background: Necrotizing enterocolitis (NEC) is a devastating disease affecting the gastrointestinal tract in premature infants with high mortality and morbidity. We aimed to analyze the research tendency and collaborations on models of NEC over the past three decades.
    Methods: Bibliometric variables of included articles were retrieved from the Web of Science Core Collection from 1994 to 2023. Visualized studies were performed via VOSviewer software. Statistical analysis was applied by using GraphPad Prism and Microsoft Excel.
    Result: A total of 255 original articles from 17 countries were included in this study. The number of articles increased significantly from 22 (the year 1994-2003) to 161 (the year 2014-2023) (P < 0.0001). Collaborations in regions and countries have increased significantly over time (P < 0.0001). Developed regions contributed most of the research. While rat (56.08%) held the leading position in all types of models, followed by mouse (30.20%), notably, the proportion of mouse model has increased significantly from 4.55% to 41.36%.
    Conclusion: This study might provide valuable insights into the model research of NEC. Research tendency has evolved to be collaborative and inclusive with more collaborations, broad model types, and studies from developing regions. However, the lack of an evident and robust pathophysiology mechanism will continue to make NEC a quite challenging case to decode, and research with strong evidence level and high quality is still required.
    Keywords:  bibliometrics; model; necrotizing enterocolitis; tendency; visualized study
    DOI:  https://doi.org/10.1097/MS9.0000000000002840
  81. Hosp Pharm. 2025 Mar 12. 00185787251326237
    Association Between Experienced Mentorship and Successful Publication of PGY1 Resident Research at an Academic Medical Center.
    Melanie Datt, Andrea Sikora, Kelli Henry.
      Purpose: ASHP Residency Standards consider research an important component of residency training. Publication of these projects is considered the gold standard for high quality research; however, residency research publication rates are low, with most reports suggesting less than 12% of projects are successfully published. This study reviewed post-graduate year one (PGY1) research projects to evaluate the role of mentorship in successful publication in peer-reviewed journals. Summary: This was a single-center, observational study of PGY1 research projects between 2010 and 2022 to assess mentorship's association with publication rate. Successful publication was confirmed via a PubMed search conducted through October 2022. Of 53 included PGY1 research projects, 18 projects (34%) were published, with 12 as manuscript publications and 6 as published abstracts. Projects with mentors with ≥3 publications and with mentors with ≥1 first author publications were associated with higher rates of full publications (excluding projects that were published in abstract form only) (50.0% vs 8.6%, p < 0.001; 37% vs 7.7%, p = 0.001). Faculty member participation also increased manuscript publication (63.6% vs 11.9%, p = 0.008). Publication of PGY1 projects was associated with higher rates of future publications (median 5 vs 1, p < .001). Conclusions: The presence of experienced mentors was associated with successful publication, and publishing a residency project was associated with future publications. New practitioners interested in precepting research projects may benefit from the inclusion of mentors with previous publication experience to support resident research projects.
    Keywords:  mentorship; research; residency
    DOI:  https://doi.org/10.1177/00185787251326237
  82. EJVES Vasc Forum. 2025 ;63 45-51
    Gender and Geographical Diversity in Authorship, Peer Reviewing, and Editorial Roles in the European Journal of Vascular and Endovascular Surgery Vascular Forum.
    Melina Vega de Céniga, June Fernández.
       Objective: Gender based disparities have been reported regarding principal investigator positions, authorship of medical published literature, reviewing roles, and representation in journal editorial boards. This study aimed to analyse gender and geographical differences in the authorship and editorial roles of the European Journal of Vascular and Endovascular Surgery Vascular Forum (EJVES VF).
    Methods: An observational retrospective study was performed of all consecutive submissions to EJVES VF between 2020 - 2023. Data were gathered on: first author's gender, first author's professional country, last author's gender, number of authors per submission, article type, and final editorial decision. Gender and professional country of external reviewers and editorial staff were also analysed, as well as performance indicators. The statistical analysis was descriptive and chi squared and t tests were used.
    Results: A total of 577 submitted papers were included. First authors were female (FFA) in 26.7% and 28.5% of submitted and accepted papers, and last authors (FLA) in 16.5% and 22%, respectively. The acceptance rate was 34.7% (n = 200), which was similar for FFA and male first authors (37% vs. 33.8%; p = .47). The FLA had a higher acceptance rate than male last authors (46.3% vs. 32.4%; p = 0.009). The acceptance rate of original research and review papers was 34.7% (n = 42), 28.2% (n = 101) for case reports, short reports, editorials, and surgical videos, and 52.2% for images, correspondence, and invited commentaries (p < .001). The highest acceptance rate was achieved by Europe (n = 334; 43.1%), followed by America (n = 68; 33.8%) and Australasia (n = 20; 30%) (p < .001). The journal had six female and ten male editors. The proportion of female reviewers rose from 12.4% in 2020 to 17% in 2023, and female editorial board members from 7% to 21%. Performance indicators were statistically similar for male and female reviewers.
    Conclusion: Female authorship is under represented in submitted and published papers in EJVES VF, with important geographical differences. The number and percentage of female reviewers is increasing; their performance is comparable with their male colleagues.
    Keywords:  Authorship; Diversity; Gender; Geography; Peer review; Publishing
    DOI:  https://doi.org/10.1016/j.ejvsvf.2024.12.003
  83. Front Vet Sci. 2025 ;12 1523732
    Research in veterinary sciences in Kazakhstan (2018-2023): developments, gaps and opportunities.
    Gulzhan N Yessembekova, Akhylbek K Kurishbayev, Aruzhan S Abdrakhmanova, Kuantar D Alikhanov, Asem Dj Abenova, Andres M Perez, Sarsenbay K Abdrakhmanov.
      Ensuring the welfare of livestock farms, safety of livestock products, control of epizootic situation in Kazakhstan depend on the development of scientific and technical progress. In response to this situation, in order to support the achievement of the strategic development goal, an order for the development of higher education and science in the Republic of Kazakhstan has been implemented with the aim of gradually increasing investment in scientific research to 1% of the country's gross domestic product (GDP). Our assessment of the scientific output of veterinary sciences in Kazakhstan over the five-year period 2018-2023 demonstrated progress. The total investment in veterinary science has increased to 14 billion KZT, i.e., from 2018, the funding of projects has become annual, previously it was once every 3 years. The consequence of this transformation was a 5-fold increase in the number of published articles for example, in 2022-2023 their number reached 50 compared to 2018-2019, where the number was barely 10. Despite the positive trend in veterinary science in recent years there are still gaps in the form of inadequate funding (only 20 funded projects per year with an average allocation of <200,000 USD per project), the productivity of the scientific community has been lower than expected: 91 peer-reviewed publications were published in first quartile journals over 5 years, which is an average of one publication in first quartile journals per year for every 32 PhD researchers (with a total of 584 PhDs), concentration of science only in large cities of Kazakhstan (Astana, Almaty), scientific developments of scientists are not commercialized and have no feedback with production. Thus, there is a need to continue to improve the effectiveness of veterinary research in combination with education and retraining, as well as increasing the participation of underserved regions and communities in the country.
    Keywords:  Kazakhstan; PhD; journals; publications; researchers; scientific projects; veterinary sciences
    DOI:  https://doi.org/10.3389/fvets.2025.1523732
  84. J Robot Surg. 2025 Mar 21. 19(1): 121
    Enhancing bibliometric analysis accuracy in robotic surgery: a proposal for search strategy refinement.
    Li Wang, Fan Yu, Xi Chen, Jie Tian.
      
    DOI:  https://doi.org/10.1007/s11701-025-02293-6
  85. An Bras Dermatol. 2025 Mar 17. pii: S0365-0596(25)00030-3. [Epub ahead of print]
    Anais Brasileiros de Dermatologia: who wrote this century-old history?
    Helena Cargnelutti Grimaldi, Sandro da Silva Camargo.
      The Anais Brasileiros de Dermatologia (ABD), an official publication of the Brazilian Society of Dermatology, has been published since 1925. ABD is considered the most influential dermatological journal in Latin America. By 2025, the journal will mark a significant milestone, celebrating a century of history. Over this time, it has published 99 volumes and 6,299 contributions from more than 10,800 authors. To analyze the trajectory of the journal, this study employs an applied research approach characterized by descriptive objectives and a quantitative nature. This research was based on a documentary procedure that encompassed all contributions already published in the journal. The main goal of the work was to identify the most prominent authors who have contributed to the journal and to map the largest co-authorship communities. The authors hope that this research serves as a formal recognition of the researchers who have written the history of the ABD.
    Keywords:  Authorship; Bibliometrics; Periodical; Scientific communication and diffusion
    DOI:  https://doi.org/10.1016/j.abd.2025.02.001
  86. J Pers Soc Psychol. 2025 Mar;128(3): 722-763
    The landscape of personality psychology in the new millennium: A systematic keyword analysis of journal articles from 2000 to 2021.
    John F Rauthmann, Niclas Kuper.
      What is published in personality psychology, and which trends emerge over time? We examined in six major personality-psychological journals (European Journal of Personality, Journal of Individual Differences, Journal of Personality, Journal of Personality and Social Psychology: Personality Processes and Individual Differences, Journal of Research in Personality, and Personality and Individual Differences) what content-as captured by keywords attached to journal articles (14,227 full articles, with 23,900 unique keywords that attracted a total of 62,578 mentions)-was featured in the first 2 decades of the new millennium (years 2000-2021). From 406 consolidated keywords that received 20 or more mentions across all years and journals (capturing a large portion of the literature and hence reasonably representative), we identified 44 keyword-topics, grouped into nine keyword-domains (from most to least mentioned): (Mal-)Adjustment, Basic Dispositions, Characteristic Adaptations & Narratives, Modalities, Other, Socio-Cultural, Methodology, Stability/Change, and Biological. The top 5 most mentioned keyword-topics were "B5 Constructs," "Emotion," "Internalizing," "Health/Well-being," and "Dark Tetrad," and the top 5 most mentioned keywords were personality, big five, narcissism, sex differences, and depression. We also examined co-occurrences, rank-order stabilities, trajectorial trends, and associations with citations for keywords, keyword-topics, and keyword-domains as well as similarities between the sampled journals. We cast a descriptive and systematic portrait of contemporary published personality-psychological content, contrast those insights with earlier accounts of trends in personality psychology, and venture predictions for the future. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
    DOI:  https://doi.org/10.1037/pspp0000532
  87. BMC Med Educ. 2025 Mar 19. 25(1): 402
    Visualization analysis of CBL application in Chinese and international medical education based on big data mining.
    Junyan Yue, Yun Shang, Hongkai Cui, Changhua Liang, Qingwu Wu, Junqiang Zhao, Huifang Wang, Dongmin Han, Zhiping Zhu.
       OBJECTIVE: To employ big data mining to provide a visualization analysis of Case-Based Learning (CBL) application in Chinese and international medical education, with the aim of observing the potential applications of CBL.
    METHODS: All included literature was obtained from the Web of Science (WoS) core collection database, Chinese core periodicals database, Chinese Social Sciences Citation Index (CSSCI), Chinese Science Citation Database of China National Knowledge Infrastructure (CNKI), Wangfang Database, and CQVIP Database. CiteSpace software (6.1.6R6) was used to conduct an in-depth investigation from four perspectives: quantitative analysis of literature, network analysis of co-occurring authors, network analysis of co-occurring research institutions, keyword clustering and burst analysis.
    RESULTS: A total of 721 Chinese articles and 537 English articles were included, demonstrating an exponential growth trend. Notably, no author exhibited a prolific publication rate within a short timeframe. Bursting keywords in English literature encompassed topics related to students' learning, teaching curriculum, methods, and location. In contrast, Chinese literature focused on students' learning, teaching methods, courses, application fields as well as national policy and the Ministry of Education of the People's Republic of China (MOE) guidance. The keyword clusters include research on care, community practice, special projects and groups, teaching methods, and capacity development of participants in English literature. For Chinese literature, the clusters include research national policy guidance, teaching reform, mode and evaluation and various disciplines.
    CONCLUSION: CBL holds immense potential for implementation across diverse disciplines, community practices, and special projects within medical education. The practical application of CBL is continuously evolving in response to changing times and can be seamlessly integrated into different contexts influenced by environmental factors and policies.
    Keywords:  Big data; Case-based learning; Chinese and international medical education; Visualization analysis
    DOI:  https://doi.org/10.1186/s12909-025-06933-1
  88. Cancer Med. 2025 Mar;14(6): e70673
    Transforming Brain Tumor Care: The Global Impact of Radiosurgery in Multidisciplinary Treatment Over Two Decades.
    Zerubbabel K Asfaw, Tirone Young, Cole Brown, Mehek Dehdia, Lily Huo, Kunal K Sindhu, Stanislav Lazarev, Robert Samstein, Sheryl Green, Isabelle M Germano.
       BACKGROUND: Stereotactic radiosurgery, a minimally invasive treatment delivering high doses of radiation to a well-defined target, has transformed interdisciplinary treatment paradigms since its inception. This study chronicles its adoption and evolution for brain cancer and tumors globally.
    METHODS: A systematic literature review of SRS-focused articles from 2000 to 2023 was conducted. Literature impact was evaluated using citation counts and relative citation ratio scores. Extracted data were dichotomized between US and international publications.
    RESULTS: Out of 5424 articles eligible, 538 met inclusion criteria reporting on 120,756 patients treated with SRS for brain cancer and tumors since 2000. Over time, publication rates grew significantly (p = 0.0016), with 56% of principal investigators based in the United States. Clinical articles accounted for 87% of the publications, with the remainder focused on technological advances. Relative to international studies, US publications had larger median samples (74 vs. 58, p = 0.012), higher median citations (30 vs. 19, p < 0.0001) and higher relative citation ratio scores (1.67 vs. 1.2, p < 0.00001). Gamma Knife and LINAC had roughly equal representation in US and international publications. Neurosurgery specialists authored more Gamma Knife-based articles, and radiation oncology specialists authored more LINAC-based papers (p < 0.0001). The most treated tumors were metastases (58%), skull base tumors (35%), and gliomas (7%). Radiographic control was achieved in 82% of metastatic tumor cases, with a 12% median complication rate.
    CONCLUSIONS: SRS has been widely adopted both nationally and globally and continues to be a growing field. This study corroborates the clinical efficacy of SRS and reinforces its critical role in the multidisciplinary treatment of patients with brain tumors and cancer.
    Keywords:  Gamma Knife; global neurosurgery; linear accelerator; neurosurgery; neuro‐oncology; radiation oncology; stereotactic radiosurgery
    DOI:  https://doi.org/10.1002/cam4.70673
  89. Can Assoc Radiol J. 2025 Mar 16. 8465371251324090
    Evaluation of Imaging Research Adherence to the STARD 2015 Reporting Guideline: Update 9 Years After Implementation and Baseline Assessment.
    Mohammed Kashif Al-Ghita, Haben Dawit, Sakib Kazi, Robert G Adamo, Nabil Islam, Sebastian Karpinski, Jean-Paul Salameh, Eric Lam, Hoda Osman, Danyaal Ansari, Daniël A Korevaar, Patrick M Bossuyt, Matthew D F McInnes.
      Background: Adherence of diagnostic accuracy imaging research to the STARD 2015 reporting guideline was assessed at baseline in 2016; on average, only 55% of 30 items were reported. Several knowledge translation strategies have since been implemented by the STARD group. Purpose: The purpose of this study was to evaluate the adherence of diagnostic accuracy studies recently published in imaging journals to STARD 2015, to assess for changes in the level of adherence relative to the baseline study. Methods: We performed an electronic search on MEDLINE for diagnostic accuracy studies, published between May and June of 2024, from a select group of imaging journals. The timespan was modulated to achieve a sample size of 100 to 150 included studies. Overall and item-specific adherence to STARD 2015 was evaluated, in addition to associations with journal of publication, imaging modality, study design, country of corresponding author, imaging subspecialty area, journal impact factor, and journal STARD adoption. Statistical comparison to the baseline study from 2016 was also performed. Poisson Regression and two-tailed student's tests were used to compare STARD adherence relative to variables included in subgroup analysis. Results: In the 126 included studies, average adherence to STARD 2015 was 61% (18.3/30 items; SD = 3.1), improved compared to the baseline study (55%; 16.6/30 items; SD = 2.2; P < .0001). Studies published in higher impact factor journals reported more items than those in lower impact factor journals (20.6 vs 18.4 items, P-value <.0001). There was no significant association between reporting completeness and journal of publication (P = .7), imaging modality (P = .21), country of corresponding author (P = .46), imaging subspecialty (P = .31), and journal STARD adoption status (P = .55). Conclusion: Recently published diagnostic accuracy studies reported more STARD 2015 items than studies published in 2016, but completeness of reporting is still not optimal.
    Keywords:  CONSORT; DTA; PRISMA; STARD; adherence; diagnostic accuracy studies; imaging; impact factor; knowledge translation; reporting guideline
    DOI:  https://doi.org/10.1177/08465371251324090
  90. PM R. 2025 Mar 17.
    Gender composition of spasticity-related clinical practice guideline authorship positions.
    Hannah Uhlig-Reche, Jeremy W Jacobs, Christine S Gaspard, Julie K Silver, Monica Verduzco-Gutierrez.
       BACKGROUND: The authors of clinical practice guidelines (CPGs) are considered topic experts and specialists. Studies to date have disproportionately found that women are underrepresented in CPG authorship, but no studies have investigated CPGs on spasticity published in the recent literature.
    OBJECTIVE: To determine the gender composition of author positions on spasticity-related CPGs published from 2014 to 2023.
    DESIGN: Retrospective review of literature.
    SETTING: Systematic literature search using PubMed, SCOPUS, and CINAHL databases for spasticity-related CPGs available in English and published between 2014 and 2023.
    PARTICIPANTS: Authorship positions on spasticity-related CPGs published during the defined study period.
    INTERVENTIONS: Not applicable.
    MAIN OUTCOME MEASURES: Gender composition of all author positions and physician author positions on spasticity-related CPGs published from 2014 to 2023 were compared with parity and equity benchmarks. The binomial test was used to assess for a difference in the observed versus expected distribution (parity) and the N - 1 χ2 test was used to compare the gender proportions of authorship positions with the gender proportions of the equity benchmarks.
    RESULTS: Six CPGs on spasticity were published during the study period. Most author positions were held by women (54.5%), whereas most physician author positions were held by men physicians (63%). Men physicians held significantly more positions compared with parity (p = .016). Women were overrepresented among all author positions compared with equity using total U.S. academic medicine faculty in neurology/physical medicine and rehabilitation (PM&R) at all benchmark years (95% confidence interval [CI]: 2014: 7.7-23.5; 2018: 4.2-20.0; 2022: 1.4-17.2). There was no difference in the gender composition of physician authors compared with academic medicine physicians in neurology/PM&R for any benchmark year (95% CI: 2014: -8.3 to 11.6; 2018: -2.0 to 7.9; 2022: -4.7 to 5.2).
    CONCLUSIONS: Physician authorship of recent spasticity-related CPGs comprises mostly men, a significant difference from parity but not from equity benchmarks. Women are overrepresented among total authorship positions (including nonphysicians) compared with equity, but not parity. Editorial boards should actively promote authorship diversity of these influential guidelines to minimize gender bias in health care delivery.
    DOI:  https://doi.org/10.1002/pmrj.13355
  91. J Transl Med. 2025 Mar 19. 23(1): 348
    From virtual to reality: innovative practices of digital twins in tumor therapy.
    Shiying Shen, Wenhao Qi, Xin Liu, Jianwen Zeng, Sixie Li, Xiaohong Zhu, Chaoqun Dong, Bin Wang, Yankai Shi, Jiani Yao, Bingsheng Wang, Louxia Jing, Shihua Cao, Guanmian Liang.
       BACKGROUND: As global cancer incidence and mortality rise, digital twin technology in precision medicine offers new opportunities for cancer treatment.
    OBJECTIVE: This study aims to systematically analyze the current applications, research trends, and challenges of digital twin technology in tumor therapy, while exploring future directions.
    METHODS: Relevant literature up to 2024 was retrieved from PubMed, Web of Science, and other databases. Data visualization was performed using R and VOSviewer software. The analysis includes the research initiation and trends, funding models, global research distribution, sample size analysis, and data processing and artificial intelligence applications. Furthermore, the study investigates the specific applications and effectiveness of digital twin technology in tumor diagnosis, treatment decision-making, prognosis prediction, and personalized management.
    RESULTS: Since 2020, research on digital twin technology in oncology has surged, with significant contributions from the United States, Germany, Switzerland, and China. Funding primarily comes from government agencies, particularly the National Institutes of Health in the U.S. Sample size analysis reveals that large-sample studies have greater clinical reliability, while small-sample studies emphasize technology validation. In data processing and artificial intelligence applications, the integration of medical imaging, multi-omics data, and AI algorithms is key. By combining multimodal data integration with dynamic modeling, the accuracy of digital twin models has been significantly improved. However, the integration of different data types still faces challenges related to tool interoperability and limited standardization. Specific applications of digital twin technology have shown significant advantages in diagnosis, treatment decision-making, prognosis prediction, and surgical planning.
    CONCLUSION: Digital twin technology holds substantial promise in tumor therapy by optimizing personalized treatment plans through integrated multimodal data and dynamic modeling. However, the study is limited by factors such as language restrictions, potential selection bias, and the relatively small number of published studies in this emerging field, which may affect the comprehensiveness and generalizability of our findings. Moreover, issues related to data heterogeneity, technical integration, and data privacy and ethics continue to impede its broader clinical application. Future research should promote international collaboration, establish unified interdisciplinary standards, and strengthen ethical regulations to accelerate the clinical translation of digital twin technology in cancer treatment.
    Keywords:  Bibliometric analysis; Digital twin; Digital twin model; Multi-disciplinary collaboration; Precision medicine; Precision oncology; Tumor; Virtual patients
    DOI:  https://doi.org/10.1186/s12967-025-06371-z
  92. Hum Vaccin Immunother. 2025 Dec;21(1): 2475601
    Anti-inflammatory effects of immunotherapy in clinical treatment and its potential mechanism in alleviating sleeping disorders: A systematic bibliometric study.
    Lei Wang, Si-Yan Chen, Jun-Li Li, Jian Dai, Di-Yuan Qin, Rong-Quan He, Gang Chen.
      Sleeping disorders negatively affect cancer patient management, quality of life, and recovery. Immunotherapy, a rising cancer treatment, shows potential to improve sleep quality by reducing inflammation. This study analyzed 255 publications (2000-2024) from the Web of Science Core Collection using bibliometric methods. The US and China dominate research output, with The Mayo Clinic as a key contributor. Core topics are "immunotherapy," "quality of life," and "antibodies." Emerging keywords like "cancer," "encephalitis," and "depression" highlight a shift toward clinical psychology in treating tumors and rare diseases. It is noteworthy that with the rapid expansion of immunotherapy in cancer treatment, clinical trials have shown that it can improve sleep quality in cancer patients by reducing inflammation. As its application in cancer treatment expands, immunotherapy's potential for treating sleep disorders is promising. Future development is expected to improve sleep quality and address clinical issues, offering broad prospects for patient outcomes.
    Keywords:  Immunotherapy; bibliometrics; cancer; sleeping disorders; survival
    DOI:  https://doi.org/10.1080/21645515.2025.2475601
  93. Front Res Metr Anal. 2025 ;10 1531758
    Bibliometrics effects of a new paper level classification.
    Marcos Peña-Rocha, Rocío Gómez-Crisóstomo, Vicente P Guerrero-Bote, Félix de Moya-Anegón.
      This study presents a comparative analysis between two scientific document classification systems. The first system employs the Scopus journal-based assignment method, adapted to a fractional model, while the second system uses an item-by-item system based on reclassified references according to the origin of the citers. The study's results are divided into three different sections: the first involves comparisons at the Scopus area level, the second examines comparisons at the category level, and the third tests various bibliometric indicators to identify the variations between the two systems. Highlighting the characteristics of the paper level system, it offers a reduction in the number of categories to which each document is assigned, achieving higher values of single-category assignment compared to the All Science Journal Classification (ASJC). When reclassifying areas and categories, the paper level system tends to accentuate differences at the extreme values, increasing the size of the largest categories and reducing that of the smallest ones. Moreover, the paper-by-paper system provides more homogeneous distributions in normalised impacts and adjusts values related to excellence more uniformly.
    Keywords:  ASJC; Scopus; classification systems; item-by-item classification; scientometrics
    DOI:  https://doi.org/10.3389/frma.2025.1531758
  94. Updates Surg. 2025 Mar 17.
    Exploring women representation in major surgical society annual meetings in Italy.
    Roberta Tutino, Andrea Tamburini, Roberta Dimalio, Beatrice Salmaso, Bruno Scotto, Roberto Passera, Paola De Nardi.
      Gender diversity is increasing in medical schools and among physicians, including in surgical residency and among surgeons. However, leadership roles do not appear to be growing proportionately. To assess whether gender equality within the surgical community is improving, we analyzed gender representation in leading roles at two major events within the field in Italy in 2023. Of the 1,566 participants in leadership roles, 199 (12.71%) were women and 1,368 (87.29%) were men. Women consistently made up less than 25% of session invited speakers, with the highest representation in breast (23.5%), peritoneum (21.6%), endocrine (21.5%), and emergency (20.1%) sessions. Female speakers accounted for less than 10% of the presentations in bariatric, colon, esophageal, and stomach sessions. Moreover, women made up just 5.1% and 21% of scientific secretaries in the two conferences, respectively. Gender representation was found to be independently associated with conference participation (p < 0.001), role (p < 0.001), and topic (p < 0.001). The underrepresentation of women at major annual surgical society meetings in Italy reflects a larger issue of gender disparity within the surgical field. To prevent this gender gap from perpetuating into future generations, the surgical community must prioritize this issue. A shift is needed from simply "tolerating diversity" to actively recognizing and promoting its importance.
    Keywords:  Diversity; Equality; Gender roles; Inclusion; Leadership; Surgery
    DOI:  https://doi.org/10.1007/s13304-025-02154-9
  95. J Med Internet Res. 2025 Mar 21. 27 e64679
    Quantifying Public Engagement With Science and Malinformation on COVID-19 Vaccines: Cross-Sectional Study.
    David Robert Grimes, David H Gorski.
       BACKGROUND: Medical journals are critical vanguards of research, and previous years have seen increasing public interest in and engagement with medicoscientific findings. How findings propagate and are understood and what harms erroneous claims might cause to public health remain unclear, especially on publicly contentious topics like COVID-19 vaccines. Gauging the engagement of the public with medical science and quantifying propagation patterns of medicoscientific papers are thus important undertakings. In contrast to misinformation and disinformation, which pivot on falsehood, the more nuanced issue of malinformation, where ostensibly true information is presented out of context or selectively curated to cause harm and misconception, has been less researched. As findings and facts can be selectively marshaled to present a misleading picture, it is crucial to consider this issue and its potential ramifications.
    OBJECTIVE: This study aims to quantify patterns of public engagement with medical research and the vectors of propagation taken by a high-profile incidence of medical malinformation.
    METHODS: In this work, we undertook an analysis of all altmetric engagements over a decade for 5 leading general-purpose medical journals, constituting approximately 9.8 million engagements with 84,529 papers. We identify and examine the proliferation of sentiment concerning a high-profile publication containing vaccine-negative malinformation. Engagement with this paper, with the highest altmetric score of any paper in an academic journal ever released, was tracked across media outlets worldwide and in social media users on Twitter (subsequently rebranded as X). Vectoring media sources were analyzed, and manual sentiment analysis on high-engagement Twitter shares of the paper was undertaken, contrasted with users' prior vaccine sentiment.
    RESULTS: Results of this analysis suggested that this COVID-19 scientific malinformation was much more likely to be engaged and amplified with negative by vaccine-negative Twitter accounts than neutral ones (odds ratio 58.2, 95% CI 9.7-658.0; P<.001), often alluding to the ostensible prestige of medical journals. Malinformation was frequently invoked by conspiracy theory websites and non-news sources (71/181 citations, 39.2%) on the internet to cast doubt on the efficacy of vaccination, many of whom tended to cite the paper repeatedly (51/181, 28.2%).
    CONCLUSIONS: Our findings suggest growing public interest in medical science and present evidence that medical and scientific journals need to be aware of not only the potential overt misinformation but also the more insidious impact of malinformation. Also, we discuss how journals and scientific communicators can reduce the influence of malinformation on public understanding.
    Keywords:  Twitter; altmetric analysis; altmetrics; comparative analysis; digital health; disinformation; health informatics; mHealth; malinformation; medical journals; medicoscientific; misinformation; mobile health; public engagement; public health; social media; vaccine
    DOI:  https://doi.org/10.2196/64679
  96. Chin Med. 2025 Mar 18. 20(1): 39
    Reunderstanding the classical prescription Banxia Xiexin Decoction: new perspectives from a comprehensive review of clinical research and pharmacological studies.
    Chang Liu, Pengwei Gao, Xiaoying Liu, Min Kuang, Haoran Xu, Yangming Wu, Wenjun Liu, Shengpeng Wang.
      Classical prescriptions of Chinese medicine represent the crystallized wisdom of millennia of clinical practice, enduring as cornerstones of therapeutic intervention due to their demonstrated efficacy across generations. Their evolving role in modern healthcare systems reflects shifting disease patterns, scientific advancements, and global health priorities. Banxia Xiexin Decoction (BXD), formulated by Zhang Zhongjing in the Treatise on Febrile and Miscellaneous Diseases (Shanghanlun), is a time-honored classical prescription renowned for its therapeutic versatility in managing gastrointestinal disorders, both in China and internationally. Recent advancements in clinical research and pharmacological studies on BXD underscore the necessity for a comprehensive bibliometric analysis to summarize and elucidate its specific clinical benefits. Through an extensive literature review of publications from the Web of Science, PubMed, Scopus, and the China National Knowledge Infrastructure (CNKI) between 1997 and 2024, 11 major categories of clinical applications for BXD were identified, along with an analysis of the potential pharmacological mechanisms, such as chronic gastritis, functional dyspepsia, and inflammatory bowel disease. We believe this review will provide new insights into the understanding of clinical value of BXD and identify potential future perspectives for its research and development.
    Keywords:  Banxia Xiexin Decoction; Bibliometric analysis; Classical prescription; Gastric ulcer; Gastritis
    DOI:  https://doi.org/10.1186/s13020-025-01087-0
  97. Poult Sci. 2025 Mar 12. pii: S0032-5791(25)00269-X. [Epub ahead of print]104(5): 105030
    Frontiers and emerging topics in a century of Silkie chicken research: insights, challenges, and opportunities.
    Yaojun Zhu, Saeed Yakhkeshi, Anas Yusuf, Xiaoying Zhang.
      Silkie chickens are a unique breed renowned for their pigmentation, food and medicine homology properties, and distinctive appearance, making them highly valuable in exhibitions, as pets, in medicinal cuisine, and as a model for melanin research. Despite their vast potential, the growing volume of publications and patents related to Silkie chicken highlights the critical need for systematic organization, summarization, and analysis of this wealth of information. For the first time, this study employs bibliometric tools to summarize and analyze 114 years of research on Silkie chicken. Our study demonstrates that academic studies primarily focus on their nutritional value, melanin production, and genetic mechanisms, while patents emphasize food formulations, breeding methods, and purebred identification. Although there has been significant growth in publications and citations since 2001, international collaboration remains limited. This study presents the need for integrated and multidisciplinary research to unlock the full potential of Silkie chicken and provides a foundational framework for future studies and applications.
    Keywords:  Bibliometric; Nutrition; Patent; Pigmentation; Silkie chicken
    DOI:  https://doi.org/10.1016/j.psj.2025.105030
  98. Environ Monit Assess. 2025 Mar 17. 197(4): 404
    Assessing the impact of micro and nanoplastics on the productivity of vegetable crops in terrestrial horticulture: a comprehensive review.
    Harshana Galahitigama, Poorni Sandamali, Thilini Jayapra, Nandula Abesinghe, Mudalige Don Hiranya Jayasanka Senavirathna, Ma Brida Lea Diola, Maria Antonia Tanchuling.
      Micro and nano plastics (MNPs) pollution has emerged as a significant environmental issue in recent years. Plastic contamination in the environment poses risks to both human health and other organisms within the ecosystem. This review discusses the overall impact of MNPs on the performance of vegetable crops, including a global perspective on the topic. Bibliometric analysis reveals that most research on this subject has been concentrated in a few countries, although the number of studies has notably increased in recent years. MNPs accumulate in arable lands due to human activities, often altering the soil's physical, chemical, and biological properties in the rhizosphere. Vegetable crops absorb these MNPs mainly through their roots, leading to accumulation in the edible parts of the plants. Consequently, this results in phytotoxic symptoms and poor growth and development. The phytotoxic effects of MNPs are attributed to genetic and metabolic changes within the plant's cellular structure. Current research on MNPs has been limited to a few vegetable cultivars. Future studies should encompass a broader range of vegetable crops under both laboratory and field conditions to advance this burgeoning field of research. Additionally, examining various types of plastics is essential to comprehensively understanding their impact.
    Keywords:  Micro and nano plastics; Plant toxicity; Remediation strategies; Soil properties; Vegetable plants
    DOI:  https://doi.org/10.1007/s10661-025-13820-1
  99. Soc Stud Sci. 2025 Mar 19. 3063127251322880
    Who knows what a mask is … and what it does? A bibliometric and textometric study of more than a century of scientific publications on sanitary masks (1892-2023).
    Franck Cochoy, Guillaume Cabanac, Wendeline Swart.
      In this article, the authors identify the disciplines that have taken an interest in masks over time, as well as how, in what proportions, according to what concerns, with what developments, and possibly with what effects. They ask whether the multiplicity of disciplinary perspectives is likely to lead to the emergence and sharing of new concerns, especially environmental ones, or whether the balkanization and juxtaposition of disciplines may leave certain aspects in the dark and thus contribute to the persistent production of a certain kind of ignorance. Based on a bibliometric and textometric study of more than 6000 scientific articles (1892-2023), they show the extent to which the Covid-19 pandemic has turned the study of masks upside down. It has encouraged the development of multidisciplinary and even interdisciplinary approaches, even if the legacy of almost exclusively medical sciences and engineering tends to severely limit hybridizations. The study highlights the possible emergence of a new movement of 'scientization of the popular', which leads scientists to incorporate the everyday concerns of ordinary citizens into the conduct of their research, thus challenging and reversing the well-known process of popularizing science.
    Keywords:  Covid-19; environment; ignorance; interdisciplinarity; matters of concern; sanitary masks
    DOI:  https://doi.org/10.1177/03063127251322880
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