bims-evares Biomed News
on Evaluation of research
Issue of 2025–06–15
94 papers selected by
Thomas Krichel, Open Library Society
  1. Global Research Trends in Anterior Cervical Fusion Surgery: a 25-Year Bibliometric Analysis.
  2. Alarplasty: A Bibliometric Analysis of the Top 50 Cited Articles in Alar Base Reduction Techniques.
  3. Research status and trends of deep learning in colorectal cancer (2011-2023): Bibliometric analysis and visualization.
  4. Global research hotspots of stem cell therapy for rotator cuff injuries: A bibliometric and visualized analysis.
  5. Research hotspots and emerging topics in neuromyelitis optica spectrum disorder treatment: Insights from a bibliometric analysis.
  6. Global trends in aspiration pneumonia research since 1980: A bibliometric analysis.
  7. Bibliometric analysis of global research trends on ultrasound in inflammatory bowel disease: A quickly developing field.
  8. The hot spots and trends of Fc gamma receptor: A bibliometric analysis from 2004 to 2024.
  9. Trends and visualization analysis of research on MASLD-Related hepatocellular carcinoma: a bibliometric analysis.
  10. Bibliometrics of artificial intelligence applications in hepatobiliary surgery from 2014 to 2024.
  11. Retinoblastoma research trends from 1980 to 2023: a 44-year bibliometric study.
  12. A Bibliometric Analysis of Acupuncture Treatment of Postoperative Complications from 2003 to 2023.
  13. Knowledge structure analysis and network visualization of tumor-associated macrophages in hepatocellular carcinoma research: A bibliometric mapping.
  14. Socket shield technique in implant dentistry: An AI-based bibliometric analysis.
  15. Global hotspots and trends in pre-metastatic niche research: a bibliometric analysis(2005-2024).
  16. The impact of 3D printing in orthopedics and traumatology: Mapping the research landscape through bibliometrics and visualized analysis.
  17. Global trends in sitosterolemia research: A bibliometric and visualization analysis.
  18. Hotspots and frontiers of the relationship between gastric cancer and cancer-associated fibroblasts: a bibliometric analysis.
  19. Immediate dental implant placement: A bibliometric analysis of the 100 most cited articles.
  20. Bibliometric Analysis of microRNA: A Comprehensive Evaluation of Its Contribution to Acute Coronary Syndromes.
  21. From past to present: A bibliometric and visualized study of the most impactful publications on congenital diaphragmatic hernia (CDH).
  22. Mapping the Research Landscape of Climate Change and its Impact on Pregnancy and Neonatal Outcomes: A Bibliometric Analysis.
  23. Research of imaging in left Atrium: A Bibliometric Analysis.
  24. A Bibliometric and Visualization Analysis of Metabolic Reprogramming in Cardiovascular Diseases: Trends, Key Contributors, and Future Directions from 2000 to 2024.
  25. Unilateral biportal endoscopic in spine surgery: a global bibliometric analysis of research trends and influences.
  26. Global research landscape on active surveillance for papillary thyroid microcarcinoma: a bibliometric analysis.
  27. Bibliometric analysis of health-related quality of life in adolescents with type 1 diabetes.
  28. Alzheimer's Disease and Inflammation Research: A Systematic Bibliometric Review and Network Visualization of the Published Literature Between 2000 and 2023.
  29. Current status, hotspots, and trends in cancer prevention, screening, diagnosis, treatment, and rehabilitation: A bibliometric analysis.
  30. Global research trends in AI-assisted blood glucose management: a bibliometric study.
  31. Bibliometric mapping of diabetes mellitus and sarcopenia research: hotspots and emerging trends.
  32. Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis.
  33. Global research trends in endoscopy applications in submucosal tumor: A bibliometric analysis of studies published from 2010-2024.
  34. Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis.
  35. Scientific production in primary health care in Latin American and Caribbean Countries (1980-2024): A web of science perspective.
  36. Research trends and hotspots on gut microbiota in rheumatoid arthritis: a bibliometric analysis from 2004 to 2024.
  37. Bibliometric Analysis in Hyperhidrosis: Recent Publication Trends from 2015 to 2025.
  38. Quantifying Research Productivity From First-year US Integrated Plastic Surgery Residents After USMLE Step I Pass/Fail Conversion.
  39. Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis.
  40. Visual analysis of hotspots and evolutionary trends in the field of postmortem interval estimation.
  41. Bibliometric insights in surgical treatment of secondary hyperparathyroidism: Research status, hotspots, and global trends.
  42. The importance of sheep genetics and diversity: a bibliometric review.
  43. A Bibliometric Analysis of Naturopathy Treatment Modalities for Diabetes Mellitus.
  44. Gender- and discipline-specific bibliometric analysis of elite biomedical scientists: how is pharmacology performing?
  45. Knowledge mapping of global trends in DNA damage repair-related breast cancer research: a bibliometric study.
  46. Hotspots and Trends in Research on Early Warning of Infectious Diseases: A Bibliometric Analysis Using CiteSpace.
  47. Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives.
  48. Global knowledge mapping and emerging research trends in non-coding RNAs related to animal and plant male sterility: A visual analysis of CiteSpace maps.
  49. A Systematic Bibliometric Analysis of Cardiovascular Disease Risk in Obesity (2014-2024).
  50. Bibliometric insights into mobile money and data trends.
  51. The Development of Violence Research in Psychiatric Nursing: A Bibliometric Perspective.
  52. The Schmiedeberg Medal of the German Society for Experimental and Clinical Pharmacology and Toxicology: a biographical and bibliometric analysis of the 47 recipients from 1956 to 2024.
  53. Mobile eye-tracking and neuroimaging technologies reveal teaching and learning on the move: bibliometric mapping and content analysis.
  54. A Bibliometric Review of Person-Centered Care Research 2010-2024.
  55. Global Trends and Emerging Frontiers in Smoking and Smokeless Tobacco Research: A Bibliometric Analysis over the Past Decade.
  56. Landscapes, highlights and trending topics of ferroptosis research in the liver: A bibliometric analysis.
  57. Immunoregulatory role of pulmonary microbiota in lung cancer: a bibliometric analysis.
  58. Trends and Hotspots in Research on Exercise and Alzheimer's Disease: A Decade of Bibliometric Review on Prevention and Molecular Mechanisms.
  59. The Use of Artificial Intelligence in Nursing Science: Emerging Trends Through Bibliometric Analysis.
  60. Analysis of Research Hotspots and Development Trends in the Diagnosis of Lung Diseases Using Low-Dose CT Based on Bibliometrics.
  61. Bibliometric analysis of transition readiness in adolescents with chronic diseases.
  62. Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis.
  63. Plant extracts with antioxidant and hepatoprotective benefits for liver health: A bibliometric analysis of drug delivery systems.
  64. An exploratory study on the publication stages of early access articles in different bibliographic databases: A case study of IEEE journals.
  65. Thermal manipulation during egg incubation in broiler chickens: A scientometric analysis.
  66. The state of global research on poverty after SDG declaration.
  67. Mapping intellectual structures and research hotspots of chronic wound in global perspective.
  68. Front-of-package food labeling and noncommunicable disease prevention: A comprehensive bibliometric analysis of three decades.
  69. Setting the agenda for diabetes research in the state of Qatar.
  70. Citation Contamination by Paper Mill Articles in Systematic Reviews of the Life Sciences.
  71. Gender Representation Among Foot and Ankle Conference Presenters and Research Authors: A 10-year Analysis (2012 to 2022).
  72. Nature-based interventions system for the urban population with sub-healthy state: an analysis using the CiteSpace and VOSviewer.
  73. Health Equity Research in Orthopaedic Surgery: A Systematic Review and Needs Assessment.
  74. Compliance of ORL-HNS Journals in Türkiye with the Principles of Transparency.
  75. Three decades of collaboration in rheumatology: a comprehensive co-authorship network analysis (1994-2023).
  76. Scientometric analysis and historical review of diabetic encephalopathy research: Trends and hotspots (2004-2023).
  77. Trends and Mechanisms of Alzheimer's Disease and Hearing Impairment: A 20-Year Perspective.
  78. Looking to the past for mapping the future: A bibliometric review of extant creativity research in second language education.
  79. Does Leave of Absence Affect Publication Productivity for Physician Trainees During Anesthesiology Residency?
  80. Uncovering gaps and opportunities in pharmacist-led medication Reviews: Advancing medication safety and health outcomes for older adults.
  81. Bridging the gap: clinical translation of adipose-derived stem cells - a scoping review of clinical trials.
  82. Rapid Detection of Illicit Drugs: An Analysis of Research Progress and Prospects.
  83. Biographical analysis of 32 pharmacologists persecuted under the Nazi regime: scientific careers between persecution, emigration, and new beginnings.
  84. A scientometric analysis of three decades of research on workplace psychosocial hazards: Implications for policy and practice.
  85. The Art of Quality Health Science Article Writing for Peer-Reviewed Professional Journals: A Review Article.
  86. R01 Funding for Surgeons; What Are the Key Factors for Success?
  87. CS-KG 2.0: A Large-scale Knowledge Graph of Computer Science.
  88. Peer-to-peer mentorship emerges from mandatory research coursework: A social network case study.
  89. The Utilization of Patient-Reported Outcome Measures in Assessing the Treatment of Osteochondral Lesions of the Ankle Versus the Knee.
  90. A scientometric review of explosives research: Challenges and opportunities.
  91. Revolutionizing DNAzyme Biosensors: Pioneering Strategies, Advanced Immobilization, Versatile Applications, and Future Frontiers.
  92. The impact of social media for shoulder surgeons: a prevalence and correlation study with online and academic presence.
  93. The Impact of Leadership in Gender Diversity of Annual Meeting Speakers in the American Society for Surgery of the Hand.
  94. Network assortativity for a multidimensional evaluation of socio-economic territorial biases in university rankings.
  1. World Neurosurg. 2025 Jun 04. pii: S1878-8750(25)00501-7. [Epub ahead of print] 124145
    Global Research Trends in Anterior Cervical Fusion Surgery: a 25-Year Bibliometric Analysis.
    Yufei He, Hong Wang, He Liu, Chao Wu, Yuhan Guo, Fan Bai.
       BACKGROUND: Anterior cervical fusion surgery (ACFS) is a well-established surgical intervention for cervical degenerative disease. To delineate current research trends and forecast future directions and emerging hotspots, this study conducted a bibliometric analysis of ACFS over the past 25 years.
    METHODS: We conducted a search in the Web of Science Core Collection database to identify articles and reviews on ACFS from 2000 to 2024. Bibliometric analysis was performed using CiteSpace 6.3.R3 and Bibliometrix (R package).
    RESULTS: A total of 4,002 articles and reviews were analyzed. This study revealed consistent growth in publications over time. China and the United States were the leading contributors in publications, authors, and institutional output, with Rush University ranking first among institutions (226 papers). SPINE ranked first in both publication volume (n=487) and total citations (n=24,881), highlighting its pivotal role in the field. Among authors, Liu H published the most papers (n=104), while Riew KD received the highest citations (n=2,399). The most frequently used keywords were "diskectomy" (948), "spine" (826), and "fusion" (733), with "interbody fusion" being the earliest (2000) and most impactful keyword (burst strength: 45.66).
    CONCLUSION: This study provides a comprehensive overview of ACFS research over the past 25 years through bibliometric analysis. The findings enhance understanding of current research landscapes and aid in anticipating future developments in this field.
    Keywords:  Anterior cervical fusion surgery; Bibliometric analysis; CiteSpace; Postoperative complications; Trends
    DOI:  https://doi.org/10.1016/j.wneu.2025.124145
  2. Aesthetic Plast Surg. 2025 Jun 06.
    Alarplasty: A Bibliometric Analysis of the Top 50 Cited Articles in Alar Base Reduction Techniques.
    Justin J Cordero, Morvarid Mehdizadeh, Noelle Garbaccio, Lacey Foster, Dorien I Schonebaum, Jade E Smith, Samuel J Lin.
       BACKGROUND: Alarplasty, or alar base reduction, narrows the alar base and reduces nasal flaring. It is a rhinoplasty technique that has gained popularity in the last decade. This study evaluates the most cited articles, analyzes global trends in alarplasty research, and explores future directions through a bibliometric analysis.
    MATERIALS AND METHODS: Using the Web of Science Sci-Expanded Index, all articles related to alarplasty were retrieved. The top 50 articles were determined by three independent reviewers. Citation count, corresponding author, institution, journal, country, publication year, and level of evidence were evaluated.
    RESULTS: Since 1970, the top 50 cited articles on alarplasty were cited 794 times, with an average citation count of 15 and highest number of citations of 96 in the year 2023. The USA contributed the most articles (24 articles), followed by Canada (7), and Egypt (4). The majority of articles were case series (80%), and based on the "Level of Evidence Pyramid," 38 articles were level IV, 5 articles were level V, 4 articles were level III, and 3 articles were level II.
    CONCLUSION: The top 50 cited articles were mostly case series with variable levels of evidence. However, low level of evidence is expected for surgical procedures, and this bibliometric analysis may help rhinoplasty surgeons understand landmark studies and learn about the surgical techniques available for alar base reconstruction.
    LEVEL OF EVIDENCE V: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
    Keywords:  Alar base reduction; Alarplasty; Bibliometric analysis; Top cited articles
    DOI:  https://doi.org/10.1007/s00266-025-04968-9
  3. World J Gastrointest Oncol. 2025 May 15. 17(5): 103667
    Research status and trends of deep learning in colorectal cancer (2011-2023): Bibliometric analysis and visualization.
    Lu-Ying Qi, Bai-Wang Li, Jie-Qiong Chen, Hu-Po Bian, Jing-Nan Xue, Hong-Xing Zhao.
       BACKGROUND: Colorectal cancer (CRC) is the third-most prevalent cancer and the cancer with the second-highest mortality rate worldwide, representing a high public health burden. Deep learning (DL) offers advantages in the diagnosis, identification, localization, classification and prognosis of CRC patients. However, few bibliometric analyses of research hotspots and trends in the field have been performed.
    AIM: To use bibliometric approaches to analyze and visualize the current research state and development trend of DL in CRC as well as to anticipate future research directions and hotspots.
    METHODS: Datasets were retrieved from the Web of Science Core Collection for the period January 2011 to December 2023. Scimago Graphica (1.0.45), VOSviewer (1.6.20) and CiteSpace (6.3.1) were used to analyze and visualize the nation, institution, journal, author, reference and keyword indicators. Origin (2022) was utilized for plotting, and Excel (2021) was used to construct the tables.
    RESULTS: A total of 1275 publications in 538 journals from 74 countries and 2267 institutions were collected. The number of annual publications has increased over time. China (371, 29.1%), the United States (265, 20.8%) and Japan (155, 12.2%) contributed significantly to the number of articles published, accounting for 62.1% of the total publications. The United States had the strongest ties to other nations. Sun Yat-sen University in China had the highest number of publications (32). The journal with the most publications was Scientific Reports (34, Q2), whereas Gastrointestinal Endoscopy had the most co-citations (1053, Q1). Kather JN, was the author with the most articles (12) and co-citations (287). The most frequently cited reference was Deep Residual Learning for Image Recognition. Keywords were divided into six clusters, with "colorectal cancer" (12.34) having the highest outbreak intensity.
    CONCLUSION: This study highlights the current status and most active directions of the use of DL in CRC. This approach has important applications in the identification, diagnosis, localization, classification and prognosis of the disease and will remain a central focus in the future.
    Keywords:  Artificial intelligence; Bibliometric analysis; Colorectal cancer; Deep learning; Visualization
    DOI:  https://doi.org/10.4251/wjgo.v17.i5.103667
  4. J Orthop. 2025 Jun;64 199-209
    Global research hotspots of stem cell therapy for rotator cuff injuries: A bibliometric and visualized analysis.
    Xiong Wang, Zhi Zhang, Biao Cheng, Yonghu Xu, Shuming Zi.
       Objective: Rotator cuff injuries represent a prevalent cause of shoulder pain and dysfunction, significantly impacting the quality of life. Surgical repair has the potential to restore tendon integrity, alleviate symptoms, and enhance overall function. However, the limited self-healing capacity of tendons, the propensity for fragile scar tissue formation, and the risk of tendons retear necessitate the exploration of alternative approaches. Stem cell therapy has emerged as a promising and effective strategy for the regenerative repair of rotator cuff injuries. This study aims to conduct a comprehensive bibliometric analysis of this field to explore the current state of research and identify emerging focus areas.
    Methods: Publications related to stem cell therapy for rotator cuff injuries, published from 2003 to 2024, were retrieved from the Web of Science Core Collection (WoSCC). Using VOSviewer, CiteSpace, and Microsoft Excel, we analyzed and visualized publication trends, research hotspots, and emerging frontiers.
    Results: A total of 927 publications were analyzed, revealing a steady increase in the number of publications within this field, thereby indicating a growing interest. The United States and China are the leading contributors regarding research output and funding. Shanghai Jiao Tong University and the American Journal of Sports Medicine have been identified as the most productive institutions and journals, respectively. The article "Biologics for tendon repair" holds the highest citation count and provides a comprehensive understanding of tendon biology and current treatment strategies. The authors with the highest publication output and citation frequency are Mazzocca, Augustus D., and Rodeo, Scott A., respectively. Keyword analysis indicates a temporal shift, with "mesenchymal stem cells" and "rotator cuff repair" identified as predominant keywords. Recently emerged keywords include "scaffolds," "tendon stem cells," and "tenogenic differentiation," reflecting the current research hotspots, frontiers, and future directions.
    Conclusions: Stem cell therapy for rotator cuff injuries is a rapidly evolving field. Our analysis provides valuable insights into research trends and future directions, highlighting the potential of regenerative medicine and the necessity for collaborative efforts to advance this promising therapeutic approach.
    Keywords:  Bibliometric; Hotspot; Rotator cuff; Stem cells; Therapy
    DOI:  https://doi.org/10.1016/j.jor.2025.05.010
  5. Medicine (Baltimore). 2025 Jun 06. 104(23): e42850
    Research hotspots and emerging topics in neuromyelitis optica spectrum disorder treatment: Insights from a bibliometric analysis.
    Juan Wang, Guangbiao Cai, Shuang Xia, Jie Qin, Ben Liu.
       OBJECT: Effective treatment of neuromyelitis optica spectrum disorder (NMOSD) can greatly reduce the rate of disability and mortality among patients. NMOSD treatment studies are gaining prominence in academic circles. This study aims to depict the evolution and integration of NMOSD treatment over the past 20 years, identify key contributors in the field, clarify current research hotspots, and explore emerging topics that may guide future research directions.
    METHOD: Articles in this field from 2004 to 2023 were collected from the Web of Science Core Collection (WoSCC). After conducting a literature search, a comprehensive bibliometric and knowledge mapping analysis was carried out on the retrieved articles using tools such as VOSviewer, Bibliometrix, and CiteSpace.
    RESULT: The rapid growth in annual publications in this field indicates rapid progress and innovation. USA, Mayo Clinic, and Fujihara K led in productivity and impact, while the multiple sclerosis and related disorders topped in publication volume. The research hotspots in this field mainly focus on targeted biological agents. Additionally, this study has identified 3 emerging themes and conducted an in-depth exploration of their future development trends.
    CONCLUSION: In summary, this bibliometric analysis provides for the first time a comprehensive framework and frontier hot spot analysis in the field of NMOSD treatment, offering references for researchers in the field and contributing to the further development of the field.
    Keywords:  NMOSD; bibliometrics; developing trends; neuromyelitis optica spectrum disorder; treatment; visual analysis
    DOI:  https://doi.org/10.1097/MD.0000000000042850
  6. Medicine (Baltimore). 2025 Jun 06. 104(23): e42808
    Global trends in aspiration pneumonia research since 1980: A bibliometric analysis.
    Akihito Ueda, Kanji Nohara.
       BACKGROUND: Aspiration pneumonia presents a significant healthcare challenge, particularly in aging societies. Despite extensive research, a comprehensive bibliometric analysis of this field has not been previously conducted. This study aimed to systematically analyze the publication patterns, research collaborations, and thematic trends in aspiration pneumonia research between 1980 and 2024.
    METHODS: We conducted a bibliometric analysis using data from the Web of Science Core Collection database. The analysis included publication trends, citation patterns, author productivity, and research categories. Network analyses were performed using VOSviewer to visualize international collaborations, author networks, and keyword co-occurrence patterns.
    RESULTS: Our analysis of 4668 publications revealed a substantial growth in research output, from 10 publications in 1980 to 371 in 2023. The United States and Japan emerged as the 2 major centers of research output. Analysis of the research categories showed a shift from surgical perspectives during the earlier periods toward more comprehensive medical management approaches in recent years, with General Internal Medicine becoming the leading category between 2010 and 2024. The author collaboration network revealed geographically distinct research clusters with limited cross-regional interactions. Keyword co-occurrence analysis identified 4 major research domains: clinical and epidemiological aspects (41 items), treatment-related approaches (29 items), neurological and swallowing disorders (29 items), and malnutrition.
    CONCLUSION: Our findings demonstrate the evolution of aspiration pneumonia research toward an increasingly multifaceted field that integrates clinical care, rehabilitation, and preventive strategies. The distinct regional patterns in research output suggest opportunities for enhanced international collaboration to advance the current understanding of this condition.
    Keywords:  aspiration pneumonia; bibliometric analysis; elderly pneumonia; pneumonia; research trends
    DOI:  https://doi.org/10.1097/MD.0000000000042808
  7. Medicine (Baltimore). 2025 Jun 06. 104(23): e42226
    Bibliometric analysis of global research trends on ultrasound in inflammatory bowel disease: A quickly developing field.
    Mengque Xu, Beibei Lin, Xingkang He, Qingyi Mao, Wenluo Zhang, Yu Zhang, Xiaoli Chen, Huiqin He, Xin Chen, Yu Zhang, Qian Cao.
      The aim of this study was to explore the scientific hotspots related to ultrasound in inflammatory bowel disease (IBD) through bibliometric approaches. The Web of Science Core database was used to identify articles about ultrasound and IBD that were published. We retrieved articles related to ultrasound and IBD from the Science Citation Index Expanded in the Web of Science Core Collection on March 7, 2024. The bibliometric analysis was carried out using Bibliometrix and the VOSviewer. The first article was published in 1979. The average annual growth rate of the publication count was approximately 10.24% during the study period. The USA (135 publications) and Italy (132 publications) were the mainstays in this field. Allocca Mariangela (24 publications) is a prolific author, yet Maaser Christian has the most citations. Regarding journals, the Journal of Crohn's Colitis (68 publications) has the most publications on this topic. In terms of affiliations, the University of Milan (41 publications) has the highest number of publications. The co-occurrence analysis of keywords presented: diagnosis (intestine wall, activity index, etc), gastrointestinal ultrasound, management, pediatric patients. In recent years, "intestinal ultrasound," "infliximab," and "monitoring and healing" were the most active terms within these clusters. There has recently been a profusion of research on the application of ultrasound to IBD. Ultrasound examinations are beneficial tools in IBD diagnosis and assessment of treatment outcomes.
    Keywords:  Bibliometric analysis; Bibliometrix; Inflammatory bowel disease; Ultrasound; VOSviewer
    DOI:  https://doi.org/10.1097/MD.0000000000042226
  8. Medicine (Baltimore). 2025 Jun 06. 104(23): e42695
    The hot spots and trends of Fc gamma receptor: A bibliometric analysis from 2004 to 2024.
    Hui Zhang, Yupeng Wen, Ngit Shin Lai.
       INTRODUCTION: FcγR (Fc gamma receptor) is a glycoprotein involved in various biological activities, such as inflammation and tumor immunity, and new ideas about the role of FcγR have also been published recently. Our study utilized journals derived from those published from 2004 to 2024 to analyze the research hotspots and cutting-edge ideas in this field.
    METHOD: All publications were searched using the web of science core collection database. VOSviewer, the R package Biblioshiny in R-studio and CiteSpace (version 6.1.R6) were utilized to perform bibliometric analysis which focused on authors, countries, organizations, keywords, etc.
    RESULT: The analysis of this article is based on 6849 articles related to FcγR from 107 countries and 37,487. The most cited reference in FcγR field is the article "Fcgamma Receptors as Regulators of Immune Responses," authored by Nimmerjahn. Country/region analysis shows that the United States of America (USA) has far more citation frequency and publications than other countries. The most recent hotspots and keywords are "COVID-19" and "SARS-CoV-2."
    DISCUSSION: Through bibliometric analysis, we can clearly recognize the evolution of the field of FcγR research, from the original cellular immunity to tumor immunity to the occurrence of the latest viral immunity, which may guide the direction of research in the field and allow researchers to be more aware of the current status and frontiers of the field.
    Keywords:  CiteSpace; Fc gamma receptor; VOSviewer; bibliometric; web of science core collection
    DOI:  https://doi.org/10.1097/MD.0000000000042695
  9. Discov Oncol. 2025 Jun 11. 16(1): 1057
    Trends and visualization analysis of research on MASLD-Related hepatocellular carcinoma: a bibliometric analysis.
    Hongkun Yin, Xusheng Zhang, Qi Wang.
       BACKGROUND AND OBJECTIVES: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is one of the leading causes of hepatocellular carcinoma (HCC). Over the years, significant progress has been made in diagnosing and treating MASLD. However, there is a lack of bibliometric analysis exploring the relationship between MASLD and HCC. This study aims to comprehensively analyze the knowledge structure and research status of MASLD-related HCC using bibliometric methods.
    METHODS: The study was conducted using the Web of Science Core Collection (WoSCC) database, retrieving literature related to MASLD and HCC from 2020 to 2024. VOSviewer, CiteSpace, and the R package "bibliometrics" were used for data analysis.
    RESULTS: The study included 2,576 articles from 97 countries. The results showed that the number of publications related to MASLD and HCC increased steadily until 2023, after which there was a slight decline. China (The People's Republic of China) is the country with the highest volume of research output, while the United States is the country with the highest number of citations. The University of California System, the Chinese University of Hong Kong, and the Egyptian Knowledge Bank were the leading contributing institutions. The International Journal of Molecular Sciences, Cancers, and Liver International were the most influential journals in this field, with the International Journal of Molecular Sciences being the most co-cited journal, and the Journal of Hepatology had the highest local impact in the field, as evaluated by the H-index. The publications were authored by 13,851 researchers, with Vincent Wai-Sun Wong, Masato Yoneda, and Rohit Loomba being the most influential authors in the field of MASLD and HCC. Rohit Loomba and Hashem B. El-Serag were the most cited authors. Trend analysis indicated that "tissue", "element-binding protein", and "contributes" were the most frequently studied topics in 2024, suggesting emerging research trends.
    CONCLUSION: This study provides a comprehensive summary of the research trends and developments in HCC related to MASLD over the past five years. The findings reveal the latest research frontiers and hotspots in this field, offering valuable insights for future research. However, it should be noted that although the WoSCC is a widely recognized and authoritative database, it may have limitations related to regional bias, language coverage, and metadata accuracy, which could potentially affect the comprehensiveness of our analysis.
    Keywords:  Bibliometrics; CiteSpace; Hepatocellular carcinoma; MASLD; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-02858-9
  10. World J Gastrointest Surg. 2025 May 27. 17(5): 104728
    Bibliometrics of artificial intelligence applications in hepatobiliary surgery from 2014 to 2024.
    Ru-Jun Zheng, Dong-Lun Li, Hao-Min Lin, Jun-Feng Wang, Ya-Mei Luo, Yong Tang, Fan Li, Yue Hu, Song Su.
       BACKGROUND: In recent years, the rapid development of artificial intelligence (AI) in hepatobiliary surgery research has led to an increase in articles exploring its benefits. We performed a bibliometric analysis of AI applications in hepatobiliary surgery to better delineate the contemporary state of AI application in hepatobiliary surgery and potential future trajectories.
    AIM: To provide clinical practitioners with a reliable reference point. It offers a detailed overview of the development of AI in hepatobiliary surgery by systematically examining the contributions of authors, countries, institutions, journals, and keywords in this domain over the last 10 years.
    METHODS: The academic resources utilized in this study were obtained from the Web of Science Core Collection database. The search results were subsequently integrated and imported into CiteSpace and VOSviewer software for the purpose of visual analysis.
    RESULTS: The study analyzed 2552 publications during 2014-2024. These publications collectively garnered 32 628 citations, averaging 15.66 citations per paper. The top contributor to this field was China. The USA had the highest citation count. The author with the highest citation count was Summers RM. In terms of the number of articles published, the leading journals were Medical Physics. Excluding the subject search terms, the most frequently used keywords included "classification", "CT and "diagnosis".
    CONCLUSION: This bibliometric analysis indicates that research on AI in hepatobiliary surgery has entered a period of rapid development, particularly in the domain of disease imaging diagnostics.
    Keywords:  Artificial intelligence; Bibliometrics; Computed tomography; Deep learning; Hepatobiliary surgery
    DOI:  https://doi.org/10.4240/wjgs.v17.i5.104728
  11. Front Oncol. 2025 ;15 1549387
    Retinoblastoma research trends from 1980 to 2023: a 44-year bibliometric study.
    Yun Zhao, Yining Wang, Yuchuan Wang, Jiagen Li, Hongxun Li, Hong Zhao.
       Background: Retinoblastoma (RB) is the most common intraocular malignant tumor in children. It not only seriously threatens patients' vision but also endangers their lives if not treated in time. Our objective is to analyze research trends in the RB field and compare contributions from different countries, institutions and authors.
    Methods: We extracted all RB-related publications published from 1980 to 2023 from the Web of Science database and applied VOSviewer, R software, Bibliometrix software, Origin 2024 and CiteSpace to review the publication data, analyze the publication trends, and visualize the relevant data. In this study, the research papers on RB published in the past 44 years were classified by year, country/region, institution/university, journal, author and keywords to reveal the research hotspots and development trends in this field.
    Results: A total of 4156 papers on RB were identified from 1980 to 2023. In 1980, only 13 papers were published, yet by 2023, 237 papers had been published. These publications were contributed by 351 research institutes from 68 countries/regions. The United States ranked first with 1662 papers, accounting for 39.99% of the total number of publications on RB research. A total of 539 RB research papers were published in China, ranking second. India, Canada and Germany ranked third, fourth and fifth, with 377, 277 and 221 publications, respectively. Thomas Jefferson University published the most research papers on RB, with 166 published papers, accounting for 3.99% of all publications. The top three journals contributing to this field were Invest Ophth Vis Sci, the British Journal of Ophthalmology and Ophthalmology. Liquid biopsy, intra-arterial chemotherapy and intravitreal chemotherapy are the most frequently used keywords in the field.
    Conclusion: Over the past 44 years, the United States, China, India, Canada and Germany have led the field of research on RB. Many renowned research institutions and ophthalmologists have made important contributions to RB research and will continue to lead this research direction. Liquid biopsy, intra-arterial chemotherapy and intravitreal chemotherapy are potential hotspots for RB research in the future.
    Keywords:  CiteSpace; bibliometric analysis; intravitreal chemotherapy; publication trends; retinoblastoma
    DOI:  https://doi.org/10.3389/fonc.2025.1549387
  12. J Multidiscip Healthc. 2025 ;18 3269-3287
    A Bibliometric Analysis of Acupuncture Treatment of Postoperative Complications from 2003 to 2023.
    Daocheng Zhu, Wei Xu, Wenguo Ye, Yuexia Jiang, Lin Jiao, Rixin Chen.
       Background: Postoperative complications refer to some related clinical symptoms that occur after surgery, which can affect7 the patient's recovery. Acupuncture has a good effects on postoperative complications, which can accelerate postoperative recovery. Currently, there are many literature studies in this field. However, there has been no quantitative analysis of these literature. Therefore, in this study, the bibliometric method was adopted to analyze the relevant literature, thereby exploring the research hotspots and trends in this field.
    Methods: Through the web of science core database, we collected the relevant literature on the acupuncture treatment of postoperative complications from 2003 to 2023, used citespace software to analyze the author, publishing institution, country, keywords, references, cited journals and other information of these literature, and analyzed its research hotspots and research trends through a visual view.
    Results: A total of 213 articles were obtained, and the annual publication volume overall is on the rise, especially in recent years when the publication volume has surged. The field with the highest number of publications is Integrative Complementary Medicine. The most cited journal is Evidence-Based Complementary and Alternative Medicine. The country with the highest number of publications is China, and the institution with the highest number of publications is Capital Medical University. The author with the highest number of publications is Zhu, Junchao. The most central cited author is LEE A. The articles with the highest frequency and centrality of cited references are published by Liu, Y. H. The most frequently studied keywords are acupuncture.
    Conclusion: This study systematically analyzes the current research status and hotspots of acupuncture treatment for postoperative complications in the past 20 years, which can help researchers grasp the current research direction and provide reference basis for further research.
    Keywords:  acupuncture; bibliometric analysis; postoperative complications; research trends
    DOI:  https://doi.org/10.2147/JMDH.S528696
  13. World J Clin Oncol. 2025 May 24. 16(5): 102747
    Knowledge structure analysis and network visualization of tumor-associated macrophages in hepatocellular carcinoma research: A bibliometric mapping.
    Ping-Li Mo, Ming Lin, Bo-Wen Gao, Shang-Bin Zhang, Jian-Ping Chen.
       BACKGROUND: Tumor-associated macrophages (TAMs) have demonstrated significant potential as a research and treatment approach for hepatocellular carcinoma (HCC). Nevertheless, a comprehensive quantitative analysis of TAMs in HCC remained insufficient. Therefore, the objective of this study was to employ bibliometric methods to investigate the development trends and research frontiers pertaining to this field.
    AIM: To determine the knowledge structure and current research hotspots by bibliometric analysis of scholarly papers pertaining to TAMs in HCC.
    METHODS: The present study employed the Web of Science Core Collection to identify all papers related to TAMs in HCC research. Utilizing the Analysis Platform of Bibliometrics, CiteSpace 6.2.R4, and Vosviewer 1.6.19, the study conducted a comprehensive analysis encompassing multiple dimensions such as publication quantity, countries of origin, affiliated institutions, publishing journals, contributing authors, co-references, author keywords, and emerging frontiers within this research domain.
    RESULTS: A thorough examination was undertaken on 818 papers within this particular field, published between January 1, 1985 to September 1, 2023, which has witnessed a substantial surge in scholarly contributions since 2012, with a notable outbreak in 2019. China was serving as the central hub in this field, with Fudan University leading in terms of publications and citations. Chinese scholars have taken the forefront in driving the research expansion within this field. Hepatology emerged as the most influential journal in this field. The study by Qian and Pollard in 2010 received the highest number of co-citations. It was observed that the citation bursts of references coincided with the outbreak of publications. Notably, "tumor microenvironment", "immunotherapy", "prognostic", "inflammation", and "polarization", etc. emerged as frequently occurring keywords in this field. Of particular interest, "immune evasion", "immune infiltration", and "cancer genome atlas" were identified as emerging frontiers in recent research.
    CONCLUSION: The field of TAMs in HCC exhibited considerable potential, as evidenced by the promising prospects of immunotherapeutic interventions targeting TAMs for the amelioration of HCC. The emerging frontiers in this field primarily revolved around modulating the immunosuppressive characteristics of TAMs within a liver-specific immune environment, with a focus on how to counter immune evasion and reduce immune infiltration.
    Keywords:  Bibliometric analysis; Hepatocellular carcinoma; Immune evasion; Immune infiltration; Tumor-associated macrophages
    DOI:  https://doi.org/10.5306/wjco.v16.i5.102747
  14. J Prosthet Dent. 2025 Jun 11. pii: S0022-3913(25)00456-1. [Epub ahead of print]
    Socket shield technique in implant dentistry: An AI-based bibliometric analysis.
    Qiao Fang, Remya Ampadi Ramachandran, Merve Koseoglu, Joseph Kan, Cortino Sukotjo.
       STATEMENT OF PROBLEM: The socket shield technique (SST) has become an innovative approach to dental implant placement and is aimed at preserving facial bone integrity and enhancing esthetic outcomes. Despite its increasing adoption, comprehensive bibliometric analyses specific to the SST are lacking.
    PURPOSE: The purpose of this study was to perform a bibliometric analysis of research into the SST using advanced artificial intelligence (AI) tools to map the scientific landscape and identify emerging trends, influential authors, and key research areas.
    MATERIAL AND METHODS: The study was conducted using a metadata search query to identify relevant SST articles published in the Scopus database from 2010 to 2024. AI-assisted screening and automated metadata extraction via the Scopus API facilitated data collection. A manual verification process was conducted by domain experts to refine and validate AI-selected articles. Bibliometric analysis was performed using the R bibliometrix package and visualization tools such as VOS Viewer and Python to examine publication trends, citation patterns, and co-authorship networks.
    RESULTS: A total of 157 articles were identified, with publication output showing a steady increase, particularly after 2015. The bibliometric analysis identified the leading contributors in terms of publication count and authorship influence. The United States led in overall publication volume and collaborative international publications, whereas China produced the most single-country publications. Germany had the highest total citations, as well as the highest average article citations. Early conceptual work continued to have a lasting impact on subsequent research. The International Journal of Periodontics and Restorative Dentistry published the largest number of articles related to SST.
    CONCLUSIONS: The bibliometric analysis demonstrates that SST research is growing rapidly, with significant contributions from both the academic and clinical sectors. AI-enhanced bibliometric methods could be effective in identifying key trends and can be applied to guide future studies in implant dentistry.
    DOI:  https://doi.org/10.1016/j.prosdent.2025.05.014
  15. Front Immunol. 2025 ;16 1552053
    Global hotspots and trends in pre-metastatic niche research: a bibliometric analysis(2005-2024).
    Mengqi Cheng, Qianhui Sun, Hua Duan, Cihui Chen.
       Background: The pre-metastatic niche (PMN) represents the microenvironment established in target organs before primary tumor metastasis, playing a crucial role in organ-specific metastasis. Understanding and preventing PMN formation holds promise for enhancing immunotherapy efficacy and reducing cancer-related mortality. Despite the significance of this field, a comprehensive bibliometric analysis is lacking. This study aims to identify global research trends and hotspots in PMN through a systematic bibliometric evaluation, providing a foundation for future advancements in this field.
    Methods: Publications related to PMN research from 2005 to 2024 were retrieved from the Web of Science Core Collection database. Bibliometric analyses and visualizations were conducted using VOSviewer, CiteSpace, Microsoft Excel, ArcGIS, Scimago Graphica, and Microsoft Charticulator.
    Results: The study included 1,303 publications authored by 7,955 researchers from 1,627 institutions across 62 countries, with articles published in 400 journals. China and the United States emerged as central contributors to global PMN research. China has led in publication volume and institutional representation, while the United States has produced the most high-quality papers and impactful authors. Cancers published the most PMN-related papers, while Cancer Research had the most citations and co-citations. Professor David Lyden of Cornell University, USA, was identified as the most influential scholar in the field. Analysis of references and keywords suggests future research will focus on metastatic organotropism, extracellular vesicles, innate immunocytes (e.g., macrophages and neutrophils), and immunotherapy.
    Conclusion: This bibliometric study represents the first comprehensive analysis of global scientific output in PMN research over the past two decades. By summarizing the current status and identifying trends in the field, this study provides valuable insights and a reference point for researchers aiming to prevent and treat tumor metastasis effectively.
    Keywords:  PMN; bibliometric analysis; extracellular vesicles; immunotherapy; metastasis; metastatic organotropism; pre-metastatic niche; research hotspots
    DOI:  https://doi.org/10.3389/fimmu.2025.1552053
  16. J Orthop. 2025 Aug;66 179-187
    The impact of 3D printing in orthopedics and traumatology: Mapping the research landscape through bibliometrics and visualized analysis.
    Iyer Rojas, Edwin F Mio-Rodriguez, Fabriccio J Visconti-Lopez.
       Objective: This study conducts a bibliometric analysis to evaluate the research landscape of 3D printing in orthopedics and traumatology.
    Methods: A bibliometric analysis was performed on articles retrieved from the Web of Science Core Collection (Orthopedics category) up to 2024, using keywords related to "3D Printing" and "Additive Manufacturing." After manual screening of 434 initial manuscripts, 412 publications were selected. Data analysis utilized the Bibliometrix R package and VOSviewer for network visualization, with manual data standardization.
    Results: The analysis identified 412 relevant publications, with a peak of 72 documents in 2023, an average document age of 3.95 years, and an annual growth rate of 41.86 %. The average number of citations per document was 14.92. China led in publication volume (210 articles) and total citations (2,264), followed by the United States (68 articles). Italy and Spain were noted for a high average number of citations per document. Among the most prolific authors were Minxun Lu, Yi Luo, Li Min, and Chongqi Tu. The Journal of Orthopaedic Surgery and Research (81 publications) and Orthopaedic Surgery (76 publications) were the journals with the most articles. Sichuan University was the leading institution (41 publications), followed by Southern Medical University (29) and Shanghai Jiao Tong University (19). Keyword analysis indicated a shift from terms like "hydrogels" and "template" (2019) to "osteogenesis," "personalized," and "sarcoma" (2023), in addition to consistently important terms like "reconstruction," "prosthesis," and "fixation."
    Conclusions: 3D printing is a transformative technology in orthopedics, significantly enhancing preoperative planning and enabling patient-specific solutions. The marked increase in publications, particularly from Chinese institutions, highlights growing global interest. Evolving keyword trends suggest a move towards regenerative strategies and precision oncology. International collaboration is vital for continued innovation, and future research should focus on integrating technological advancements with clinical outcomes.
    Keywords:  3D printing; Bibliometric analysis; Customized implants; Orthopedics; Research collaboration; Traumatology
    DOI:  https://doi.org/10.1016/j.jor.2025.05.030
  17. J Clin Lipidol. 2025 May 07. pii: S1933-2874(25)00276-4. [Epub ahead of print]
    Global trends in sitosterolemia research: A bibliometric and visualization analysis.
    Hui Wu, Yinfei Xu, Rong Cheng, Haoyang Zhou, Ying Li, Ziyi Lu, Cheng Zhang, Chunyu Li, Yan Chen.
       BACKGROUND: Sitosterolemia is a rare autosomal recessive genetic lipid metabolism disorder characterized by high concentrations of plant sterols in plasma and tissues, which can cause a variety of clinical symptoms, such as xanthomatosis, atherosclerosis, and arthritis. In recent years, more and more scholars have begun to pay attention to the special disease of sitosterolemia. Bibliometrics analysis, as a method of quantitative analysis of scientific literature, can help us systematically understand the research status and development trends in this field. In this study, CiteSpace software was used to analyze the literature on sitosterolemia.
    SOURCES OF MATERIAL: Publications on sitosterolemia were collected from the Web of Science Core Collection (WOSCC) and Pubmed. The bibliometric tools CiteSpace software and Microsoft Excel were used to identify the historical features, the evolution of active topics, and emerging trends in the sitosterolemia field.
    ABSTRACT OF FINDINGS: A total of 885 publications were retrieved and 416 publications were included in the analysis after the removal of duplicates. From 1974 to 2024, the number of publications and the related citations show an obvious fluctuating trend. The top 3 institutions with the most publications were the University of Bonn, the University of Texas System, and the University of Texas Southwestern Medical Center Dallas; the top 3 authors with the most publications were Patel, Shailendra B, Tada Hayato and Salen, G. The research hotspots on sitosterolemia mainly focus on phytosterols, whole exome sequencing and lipid metabolism. The top 5 keywords by frequency of occurrence were "sitosterolemia," "humans," "dietary-cholesterol," "cholesterol," and "absorption." There is extensive scientific research cooperation among the sitosterolemia research institutions. Genetic research remains an important and ongoing area of interest in the study of sitosterolemia, given the fundamental role of genetic mutations in the disease's pathogenesis.
    CONCLUSION: The findings based on the bibliometric studies provide the current status and trends in sitosterolemia research and may help researchers identify hot topics and explore new research directions in this field.
    Keywords:  Bibliometric analysis; CiteSpace; Sitosterolemia
    DOI:  https://doi.org/10.1016/j.jacl.2025.04.201
  18. Front Oncol. 2025 ;15 1576696
    Hotspots and frontiers of the relationship between gastric cancer and cancer-associated fibroblasts: a bibliometric analysis.
    Xiangcheng Hu, Lingling Ren, Shuyuan Zhu, Haiping Shen, Chengyong Qian, Guanglan Chen, Fangling Chen.
       Background: Cancer-Associated Fibroblasts (CAFs) are pivotal stromal constituents within the Tumor Microenvironment (TME), characterized by marked heterogeneity and plasticity. Over the past two decades, a notable association between Gastric Cancer (GC) and CAFs has been established. Despite this, there remains a paucity of comprehensive data to guide researchers in understanding the prevalence and potential research trajectories concerning GC and CAFs.
    Methods: This study conducted an extensive literature search within the Web of Science Core Collection database from January 1, 2003, to December 31, 2023. Bibliometric analysis and visualization were performed using VOSviewer, CiteSpace, R software, and Microsoft Excel.
    Results: A total of 1170 articles were included. These articles were disseminated across 200 journals and incorporated 1800 distinct keywords. A notable surge in publications has been observed from 2011 to 2023. China emerged as the leading contributor to both article count and citations. Prominent research institutions in this domain include Osaka City University, Shanghai Jiaotong University, and National Cancer Research Center Hospital. Notable researchers, such as Masakazu Yashiro and Kosei Hirakawa from Osaka City University and Zhenggang Zhu from Shanghai Jiaotong University, were among the most productive and highly cited authors. FRONTIERS IN ONCOLOGY boasts the highest number of publications, whereas ONCOGENE ranks as the most cited journal. The primary research foci within the realm of CAFs and GC encompass the impact of CAFs on GC cell proliferation, angiogenesis, invasion, metastasis, epithelial-mesenchymal transition, immunosuppression, drug resistance, and the interplay between CAFs and GC.
    Conclusion: Using bibliometric analysis, this study presents a panoramic view of the research landscape of CAFs and GC from 2003 to 2023. It highlights prominent research areas and anticipates future directions with the aim of offering valuable insights and strategic recommendations for future endeavors in this field.
    Keywords:  bibliometrics; cancer-associated fibroblasts; gastric cancer; hot spot; tumor microenvironment
    DOI:  https://doi.org/10.3389/fonc.2025.1576696
  19. J Clin Exp Dent. 2025 May;17(5): e507-e514
    Immediate dental implant placement: A bibliometric analysis of the 100 most cited articles.
    Lucas Menezes Dos Anjos, Aurélio de Oliveira Rocha, Felipe Gomes Dallepiane, Fernanda Pretto Zatt, Filipe Colombo Vitali, Pablo Silveira Santos, Christiane Cabral Leite, Natalia de Oliveira Miranda, Ariadne Cristiane Cabral Cruz, Mariane Cardoso, Bruno Henriques.
       Background: This study aims to scrutinize the characteristics of the 100 most cited articles concerning the immediate placement of dental implants.
    Material and Methods: Employing a specific search strategy comprising keywords and Boolean operators, we conducted a comprehensive search in the Web of Science database in January 2024. The identified articles were then arranged in descending order based on their citation counts. Two researchers meticulously gathered information on the number and density of citations, publication year and journal, study design, authorship and affiliations, keywords, as well as the country and continent of origin. Bibliometric maps were constructed using VOSviewer.
    Results: The citations for the selected articles ranged from 76 to 569, spanning the publication years 1994 to 2018. Clinical Oral Implants Research emerged as the most frequently referenced journal, accounting for 30% of the publications. Interventional studies constituted the majority (29%) of the articles. Buser D and Lang NP were the most prolific authors, each contributing 11% of the published articles. The University of Bern had a total representation of 10%. The United States garnered significant attention at 20%, while Europe emerged as the predominant continent, constituting 46% of the publications. VOSviewer maps illustrated a convergence of authorship.
    Conclusions: The 100 most cited articles on immediate implant placement predominantly originated from authors in the United States, emphasizing Clinical Oral Implants Research as a notable outlet featuring observational studies. Key words:Immediate implantation, Bibliometric analysis, Dental implants.
    DOI:  https://doi.org/10.4317/jced.62274
  20. J Multidiscip Healthc. 2025 ;18 3121-3137
    Bibliometric Analysis of microRNA: A Comprehensive Evaluation of Its Contribution to Acute Coronary Syndromes.
    Yuqian Gao, Tianli Li, Xiaohong Mu, Xiaoxia Ren, Jing Wang, Jiasai Fan, Haiyan Zhu, Xian Wang.
       Objective: This study employs bibliometric analysis to map the evolution, identify emerging trends, and evaluate key research themes in microRNA (miRNA) research related to Acute Coronary Syndromes (ACS). By analyzing global publications, we aim to highlight hotspots and translational directions for advancing miRNA applications in ACS diagnosis and therapy.
    Materials and Methods: Articles on miRNA and ACS published between 2007 and 2023 were retrieved from the Web of Science Core Collection. Data from 1,244 eligible studies were analyzed using CiteSpace and VOSviewer to assess contributions by countries, institutions, authors, journals, and keywords. Visualization tools mapped collaboration networks, co-citation patterns, and keyword trends.
    Results: China contributed 60% of publications, followed by the United States (12.86%). Harbin Medical University was the most productive institution, while Thum Thomas emerged as the leading researcher. Key research areas included miRNA biomarkers for ACS diagnosis, therapeutic targets for ischemia-reperfusion injury, extracellular vesicles in cardiac repair, and mechanistic studies on apoptosis, autophagy, and inflammation. Emerging frontiers encompassed ventricular remodeling post-AMI, oxidative stress, and clinical translation of miRNA-based strategies.
    Conclusion: This study provides the first comprehensive bibliometric overview of miRNA research in ACS, revealing sustained growth and interdisciplinary potential. Findings underscore China's dominance in output and the need for enhanced international collaboration to bridge gaps between basic research and clinical applications. Prioritizing extracellular vesicle-mediated therapies, optimizing miRNA delivery systems, and validating biomarkers in multicenter trials are critical for future advancements.
    Keywords:  acute coronary syndrome; bibliometric analysis; biomarkers; microRNAs; therapeutic targets; translational medicine
    DOI:  https://doi.org/10.2147/JMDH.S525150
  21. J Pediatr Surg. 2025 Jun 07. pii: S0022-3468(25)00253-2. [Epub ahead of print] 162408
    From past to present: A bibliometric and visualized study of the most impactful publications on congenital diaphragmatic hernia (CDH).
    Boshen Shu, Jan Riedel, Jan-Hendrik Gosemann, Richard Wagner, Nicole Peukert, Martin Lacher, Steffi Mayer, Ophelia Aubert.
       BACKGROUND: Congenital diaphragmatic hernia (CDH) is a severe birth defect characterized by significant infant mortality and morbidity. While numerous articles have been published on CDH, little is known about the characteristics of the most impactful articles. In this study, we aimed to identify and characterize the most important publications in the CDH field from a bibliometric perspective.
    METHODS: Articles addressing CDH were retrieved in October 2024 from the Web of Science™ and ranked by citation number. The top 100 publications were analyzed for their bibliometric parameters including number of citations, subject of study, level of evidence, country of origin, journals and publication year. A visualized study of identified articles was performed using the VOSviewer software.
    RESULTS: In total, 4,637 publications with 84,163 citations from 713 journals were identified. The 100 most cited papers were published between 1962 and 2018, mainly in the Journal of Pediatric Surgery (37%). The USA was the leading country for number of publication and degree of collaboration with other countries. Citations per article ranged from 117 to 497 (median 162). Retrospective studies (36%) and studies with low evidence level IV (41%) dominated. The terms CDH, extracorporeal membrane oxygenation (ECMO), survival, pulmonary hypoplasia, preoperative stabilization, prenatal diagnosis, high frequency oscillatory ventilation (HFOV) and fetoscopic endoluminal tracheal occlusion (FETO) were identified as high-frequency keywords in co-occurrence analysis. Morbidity and mortality (21%), surgical management (16%) and animal model research (14%) were the top three topics of interest.
    CONCLUSIONS: Our findings identify the most referenced works, including the countries and journals of origin, in CDH over the past five decades. These manuscripts highlight advances in the understanding and management, with an increased focus on prenatal diagnosis, long-term outcomes and innovative treatments. However, the field remains hindered by a lack of high-level evidence studies, underscoring the need for more randomized controlled trials and translational research to improve clinical outcomes.
    LEVEL OF EVIDENCE: IV.
    Keywords:  CDH; Congenital diaphragmatic hernia; VOSviewer; bibliometrics; publishing trend; research activity
    DOI:  https://doi.org/10.1016/j.jpedsurg.2025.162408
  22. J Epidemiol Glob Health. 2025 Jun 10. 15(1): 83
    Mapping the Research Landscape of Climate Change and its Impact on Pregnancy and Neonatal Outcomes: A Bibliometric Analysis.
    Xinyan Zhang, Yan He, Yuxin Liu, Jun Guan, Feng Jiang, Weirong Gu.
       BACKGROUND: Climate change has emerged as a critical global health threat, with growing evidence linking environmental stressors such as heatwaves, air pollution, and temperature variability to adverse pregnancy and neonatal outcomes. However, the structure, evolution, and research hotspots within this interdisciplinary field remain insufficiently understood.
    METHODS: We conducted a bibliometric analysis of 1,393 English-language publications (2001-2024) retrieved from the Web of Science Core Collection (WoSCC) using a predefined search strategy. CiteSpace was used for knowledge mapping, including co-authorship, co-citation, keyword clustering, and temporal trend analyses.
    RESULTS: The number of publications increased markedly after 2017. The United States, China, and the United Kingdom were the most productive countries, with leading institutions including the University of California and Harvard University. Influential authors such as Basu R, Dadvand P, and Chersich MF shaped the field's development. High-frequency keywords included "climate change," "preterm birth," and "air pollution." Keyword clusters and citation bursts highlighted evolving themes such as oxidative stress, brown adipose tissue, and maternal thermoregulation.
    CONCLUSIONS: This study provides a comprehensive visual and quantitative overview of the research landscape linking climate change with maternal and neonatal health. The findings highlight the growing interdisciplinarity of the field and underscore the need for future research to explore underlying biological mechanisms, prioritize vulnerable populations through equity-focused studies, and inform the development of targeted climate adaptation and mitigation strategies in low-resource settings. These insights can support evidence-based policymaking and guide resource allocation to safeguard maternal and child health amid a changing climate.
    Keywords:  Air pollution; Bibliometric analysis; Climate change; Neonatal health; Pregnancy outcomes
    DOI:  https://doi.org/10.1007/s44197-025-00431-9
  23. Curr Med Imaging. 2025 Jun 10.
    Research of imaging in left Atrium: A Bibliometric Analysis.
    Can Cui, Jiang-Hua Zhu, Ya-Hong Tao, Zhen-Yi Zhao, Yun Peng, Minjing Zuo.
       BACKGROUND: The evaluation of the left atrial (LA) by imaging is becoming increasingly essential due to its significant role in numerous diseases. This study aimed to analyze and summarize research on LA imaging in the past 20 years through bibliometric analysis and offer insights into future research prospects.
    METHODS: The Web of Science (WOS) core collection database was retrieved for literature in LA imaging research from 2004 to 2023. Subsequently, the literature was processed and visualized by the VOSviewer and CiteSpace. VOSviewer was used to create cooperation networks for countries/regions and institutions. CiteSpace was used to analyze burst keywords in citation analysis.
    RESULTS: A total of 3664 articles published in this field between January 2004 and December 2023 were analyzed. The number of published articles is increasing year by year. The USA contributed the most articles (1072). Hugh Calkins (44) was the most productive author with the highest publications.
    CONCLUSION: Over the past 20 years, research on LA imaging has grown rapidly. The results of the present study provide insights into the field's status and indicate the research hotspots. In recent years, research on left atrial appendage occlusion (LAAO) and LA strain has been notably focused, which is expected to remain a prominent topic in future research.
    Keywords:  Bibliometric; CiteSpace; Left atrium imaging; VOSviewer.
    DOI:  https://doi.org/10.2174/0115734056356151250604021748
  24. Curr Cardiol Rev. 2025 ;21(4): e1573403X371021
    A Bibliometric and Visualization Analysis of Metabolic Reprogramming in Cardiovascular Diseases: Trends, Key Contributors, and Future Directions from 2000 to 2024.
    Xing Chen, Liu Lin Yang, Li Xiang Li, Yan Deng.
       BACKGROUND: Metabolic reprogramming is critical in cardiovascular disease (CVD) research, affecting a variety of diseases such as myocardial damage, coronary heart disease, and atherosclerosis, and has also emerged as a therapeutic target. This study conducts a bibliometric analysis of the past 24 years to identify trends and hotspots in CVD metabolism, aiming to guide future research and inform policy.
    METHODS: This study analyzes publications from January 1, 2000, to October 10, 2024, using the Web of Science Core Collection database. Tools like CiteSpace, VOSviewer, and SCImago Graphica were used for co-authorship, keyword, citation, and journal visualizations. Dual-map overlays and annual publication trends were examined to uncover hotspots, trends, and the progression of metabolic reprogramming in CVD.
    RESULTS: This study analyzed 765 articles and reviews from 66 countries. The USA had the most publications, with the University of Milan being the most productive institution. Després, JP's team in Italy, published the most papers. The International Journal of Molecular Sciences had the highest publication count, while Cardiovascular Diabetology had the greatest citation impact. Recent research has mainly focused on the role of immune cell substrate metabolism in CVD.
    CONCLUSION: This study reveals the development trend and research characteristics of CVD metabolic reprogramming over the past 24 years, from the early focus on disease risk factors to the recent exploration of the transformation of immune cell metabolism. In the future, targeting immune cell metabolism will drive CVD therapy forward.
    Keywords:  bibliometrics; cardiovascular disease; hotspots; immune cell; metabolic reprogramming; tumor cells
    DOI:  https://doi.org/10.2174/011573403X371021250109064231
  25. Eur Spine J. 2025 Jun 07.
    Unilateral biportal endoscopic in spine surgery: a global bibliometric analysis of research trends and influences.
    Xingyuan Wu, Huilong Pan, Hangchi Wang, Jun Wang, Yile Lin, Elmar Musaev, Ruiyuan Huang, Shu Li, Jin Zhang, Haixiao Wu, Chao Zhang.
       PURPOSE: Unilateral biportal endoscopic (UBE) technique is increasingly utilized in spine surgery, offering minimally invasive solutions with promising outcomes. This study conducts a comprehensive bibliometric analysis of global research trends and key influences in UBE application.
    METHODS: A systematic search in the Web of Science Core Collection was performed on June 9, 2024, focusing on English publications related to UBE and spine surgery. Bibliographic data were analyzed using R and VOSviewer to visualize trends, collaborations, and citation networks.
    RESULTS: A total of 231 articles from 59 sources were identified, with World Neurosurgery being the most prolific journal. Publications peaked in 2023, with South Korea and China leading the field through significant collaborations. HEO DH emerged as the most productive and cited author. Key research focuses included "decompression," "surgery," and "discectomy."
    CONCLUSION: The analysis highlights increasing research interest in UBE, with key contributors and collaborations shaping advancements. It provides insights into research trends, main areas of focus, and emerging topics, guiding future UBE research and applications.
    Keywords:  Bibliometric analysis; Minimally invasive techniques; Spine surgery; Unilateral biportal endoscopic
    DOI:  https://doi.org/10.1007/s00586-025-09002-9
  26. Discov Oncol. 2025 Jun 07. 16(1): 1026
    Global research landscape on active surveillance for papillary thyroid microcarcinoma: a bibliometric analysis.
    Dong-Shu Kang, Yu-Hao Lin, Jian-Qing Tian.
       BACKGROUND: It has been proven that the active surveillance (AS) is safe and feasible for low-risk papillary thyroid microcarcinomas (PTMC). There has been no bibliometric assessment of the scientific advancements in this field. We conducted this study to determine the characteristics and trends of published research on AS for PTMC.
    METHODS: In this study, articles on AS for PTMC published between 2014 and 2024 were identified using the Web of Science Core Collection database. Bibliometric analysis and visualization were conducted using VOSviewer and CiteSpace.
    RESULTS: 277 publications from 39 countries were identified, demonstrating a growth trend between 2014 and 2024. The United States of America dominated with the highest number of published papers, followed closely by South Korea and Japan. The most significant journal was *Thyroid*, and the leading author was Akira Miyauchi. Kuma Hospital and Memorial Sloan Kettering Cancer Center emerged as leading institutions. Keyword analysis revealed that, alongside the title-related terms of this study, "management," "quality of life," "lymph node metastasis," "progression," and "association guidelines" formed the core keywords in this field.
    CONCLUSION: Active surveillance for low-risk PTMC has been endorsed and recommended by researchers in numerous countries. This study identified the current most active frontiers in this field and focused on candidate population profiling, tumor progression evaluation, cost-effectiveness of the active surveillance (AS) approach, and quality of life assessment for patients. This paper summarizes the controversial issues and provides a reference direction for researchers seeking to explore novel approaches in this field.
    Keywords:  Active surveillance; Bibliometric analysis; Hotspots; Papillary thyroid microcarcinoma; Research trends
    DOI:  https://doi.org/10.1007/s12672-025-02789-5
  27. Front Pediatr. 2025 ;13 1539116
    Bibliometric analysis of health-related quality of life in adolescents with type 1 diabetes.
    Javier Martín-Ávila, Esther Rodríguez-Jiménez, Marián Pérez-Marín, Selene Valero-Moreno.
      Type 1 Diabetes Mellitus (T1DM) affects an estimated 8.75 million individuals worldwide and commonly emerges during adolescence-a critical developmental stage marked by significant physical and psychological changes. The intersection of T1DM and adolescent development can substantially impact both mental and physical health. As a result, interventions aimed at addressing this impact often utilize the concept of health-related quality of life (HRQOL) to evaluate their effectiveness. This study aimed to identify major trends, influential authors and institutions, and leading journals in the scientific literature related to HRQOL in adolescents with T1DM, based on publications indexed in the Web of Science database. A bibliometric analysis was conducted using the Web of Science database, yielding 231 relevant articles published between 2003 and 2024. The data were analyzed to determine publication trends, geographic distribution of research activity, key contributors, and thematic evolution based on keyword analysis. The results revealed a recent surge in the production of these articles, with the United States and Germany emerging as the countries where this field is most extensively studied, collectively accounting for nearly 40% of the total output. Several authors, institutions, and journals were identified as particularly influential in this area of research. Keyword analysis suggests a paradigm shift within literature from a primarily clinical focus to a broader, multidimensional approach that emphasizes psychosocial factors, family dynamics, and self-management strategies. This trend reflects an evolving understanding of the complex interplay between disease management and quality of life in adolescents living with T1DM.
    Keywords:  HRQOL; T1DM; adolescent; bibliometric analysis; chronic illness
    DOI:  https://doi.org/10.3389/fped.2025.1539116
  28. Recent Adv Inflamm Allergy Drug Discov. 2025 Jun 12.
    Alzheimer's Disease and Inflammation Research: A Systematic Bibliometric Review and Network Visualization of the Published Literature Between 2000 and 2023.
    Khairunnuur Fairuz Azman, Che Aishah Nazariah Ismail, Nazlahshaniza Shafin, Rahimah Zakaria.
       INTRODUCTION/OBJECTIVE: Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. In recent years, inflammation has gained recognition as a key contributor to both the onset and progression of Alzheimer's disease, acting through complex pathways that include neuroinflammation and immune system dysregulation. This study aims to systematically review the relationship between Alzheimer's disease and inflammation, focusing on publication trends from 2000 to 2023.
    METHODS: Using the Scopus database, a bibliometric analysis was conducted through Microsoft Excel, Harzing's Publish or Perish, and VOSviewer, examining publication trends, citation metrics, and co-network visualization.
    RESULTS: A total of 1,205 relevant publications were identified, revealing a steady increase in research output. The majority of contributions came from the United States (33.1%), China (16.8%), and the United Kingdom (8.8%). Key terms such as "neuroinflammation", "cytokine", "microglia", "amyloid beta", and "oxidative stress" dominated the literature, while emerging keywords included "neuroprotection", "BDNF", "inflammasome", and "mitochondria".
    CONCLUSION: These findings underscore the growing focus on the role of inflammatory processes in the etiopathology of Alzheimer's disease, as well as efforts to identify biomarkers and neuroprotective therapeutic targets. This study provides a detailed mapping of the research landscape, offering insights into the evolving knowledge structure and highlighting prominent countries, institutions, authors, journals, and highly cited articles. By identifying key trends, this review advances our understanding of the interplay between inflammation and Alzheimer's disease, paving the way for future research and clinical strategies.
    Keywords:  Alzheimer’s disease; amyloid; bibliometric analysis; cytokine; inflammation; interleukin.; neuroinflammation
    DOI:  https://doi.org/10.2174/0127722708363344250529050252
  29. Oncol Res. 2025 ;33(6): 1437-1458
    Current status, hotspots, and trends in cancer prevention, screening, diagnosis, treatment, and rehabilitation: A bibliometric analysis.
    Chuchu Zhang, Ying Liu, Zehui Chen, Y I Liu, Qiyuan Mao, G E Zhang, Hongsheng Lin, Jiabin Zheng, Haiyan Li.
       Objectives: Decades of clinical and fundamental research advancements in oncology have led to significant breakthroughs such as early screening, targeted therapies, and immunotherapy, contributing to reduced mortality rates in cancer patients. Despite these achievements, cancer continues to be a major public health challenge. This study employs bibliometric techniques to visually analyze the English literature on cancer prevention, screening, diagnosis, treatment, and rehabilitation.
    Methods: We systematically reviewed publications from 01 March 2014, to 01 March 2024, indexed in the Web of Science core collection. Tools such as VOSviewer Version 1.6.20 is characterized by its core idea of co-occurrence clustering. CiteSpace 6.3.R3 is distinguished by its powerful capabilities in bibliometric analysis, including co-citation analysis, co-occurrence analysis of keywords, author collaboration network analysis, and journal co-citation analysis, providing effective insights into research hotspots and detecting emerging trends. Bibliometrix version 3.0.3 offers rich visualization features, including collaboration network diagrams, citation distribution graphs, and keyword clouds. facilitated the analysis of the literature, helping to map out the current research landscape, identify pressing issues, and discern emerging trends, thus offering insights for future research directions.
    Results: The analysis revealed that major research hotspots include lung and breast cancer. Attention is predominantly concentrated on cancer treatment, subdivided into targeted therapy, immunotherapy, traditional Chinese medicine, and the development of new anticancer drugs. Significant terms identified in the study include immune checkpoint inhibitors, tumor microenvironment, and cancer stem cells.
    Conclusion: This bibliometric analysis highlights the evolving directions in oncology research, pinpointing nanotherapy, resistance to targeted therapies, and the integration of artificial intelligence as pivotal future research avenues in the prevention, screening, diagnosis, treatment, and rehabilitation of cancer.
    Keywords:  Bibliometrics; Cancer diagnosis; Cancer prevention; Cancer rehabilitation; Cancer screening; Cancer treatment
    DOI:  https://doi.org/10.32604/or.2025.059290
  30. Front Endocrinol (Lausanne). 2025 ;16 1579640
    Global research trends in AI-assisted blood glucose management: a bibliometric study.
    Li Yuan, Yangtian Wang, Meiping Xing, Tao Liu, Dan Xiang.
       Background: AI-assisted blood glucose management has become a promising method to enhance diabetes care, leveraging technologies like continuous glucose monitoring (CGM) and predictive models. A comprehensive bibliometric analysis is needed to understand the evolving trends in this research area.
    Methods: A bibliometric analysis was performed on 482 articles from the Web of Science Core Collection, focusing on AI in blood glucose management. Data were analyzed using CiteSpace and VOSviewer to explore research trends, influential authors, and global collaborations.
    Results: The study revealed a substantial increase in publications, particularly after 2016. Major research clusters included CGM, machine learning algorithms, and predictive modeling. The United States, Italy, and the UK were prominent contributors, with key journals such as Diabetes Technology & Therapeutics leading the field.
    Conclusion: AI technologies are significantly advancing blood glucose management, especially through machine learning and predictive models. Future research should focus on clinical integration and improving accessibility to enhance patient outcomes.
    Keywords:  AI; blood glucose management; continuous glucose monitoring; diabetes; machine learning
    DOI:  https://doi.org/10.3389/fendo.2025.1579640
  31. Front Med (Lausanne). 2025 ;12 1586308
    Bibliometric mapping of diabetes mellitus and sarcopenia research: hotspots and emerging trends.
    Min Wang, Qiyang Zhou, Xinyu Guo, Xiaolong Cui, Zhongquan Tang, Ting Ou, Xiaomin Zhao, Chen Liang, Peiyu Xu, Xinyu Dai, Jingqing Yao, Guozhong Ji, Yuntao Li.
       Background: Diabetes mellitus and sarcopenia are chronic metabolic disorders characterized by bidirectional interactions, frequently coexisting as comorbidities whose interrelationship has garnered increasing scientific attention. This study pioneers a bibliometric analysis to systematically investigate their association, aiming to map the knowledge structure, evolutionary trajectories, current foci, and emerging frontiers within this area.
    Methods: We retrieved 2,773 publications from the Web of Science Core Collection from inception until December 26, 2024, and visual analyses were conducted using CiteSpace, VOSviewer, R, and Microsoft Excel. The analysis characterized disciplinary distributions, publication outputs, national/regional contributions, institutional collaborations, authorship networks, journal profiles, references, and keywords.
    Results: Annual publications demonstrated sustained growth, with the United States dominating scholarly contributions. Research exhibited marked interdisciplinary integration, although investigations linking type 1 diabetes mellitus with sarcopenia remain limited. Current research hotspots included shared pathological mechanisms such as insulin resistance and chronic inflammation, clinical characterization of specific subtypes such as sarcopenic obesity, imaging-based assessment of muscle dysfunction in diabetes, and the therapeutic efficacy of exercise as an intervention. Mechanistic exploration was determined to be the primary driver of domain advancement.
    Conclusion: The field has evolved from theoretical frameworks to clinical applications, highlighting the importance of uncovering common pathophysiological mechanisms and pinpointing potential therapeutic targets. Future priorities include refining screening and diagnostic protocols, optimizing preventive strategies, and developing personalized interventions. Cross-disciplinary innovations integrating multi-omics and precision medicine are poised to reshape this research landscape.
    Keywords:  bibliometric analysis; diabetes mellitus; muscle function; pathological mechanisms; research trends; sarcopenia
    DOI:  https://doi.org/10.3389/fmed.2025.1586308
  32. Regen Ther. 2025 Jun;29 600-612
    Historical evolution, hotspots, and trends in tendon tissue engineering: A bibliometric analysis.
    Wenlong Hou, Wenwen Liu, Mengtian Tan, Jiaxu Fang, Keye Cao, Xincheng Du, Haijun Zhang.
       Introduction: As a significant branch of tissue engineering, tendon tissue engineering has developed rapidly, driven by advancements in new technologies and the refinement of medical theories. This study summarizes its development by analyzing historical evolution, research hotspots, and future trends to reveal core research directions and potential pathways.
    Methods: Based on literature from WoS CC (1991-2024) and analyzed using VOSviewer, CiteSpace, and Bibliometrix, the study evaluates publication trends and research patterns.
    Results: Findings show continuous growth in annual publications. The United States and China are key contributors with close collaboration. Chang James is the most prolific author, and stable research teams have emerged, though inter-team cooperation remains limited. Acta Biomaterialia publishes the most papers in this field, characterized by interdisciplinary integration. Key research focuses include scaffolds, seed cells, and rotator cuff injuries. Frontiers involve ideal scaffold construction, tendon adhesion prevention, and regeneration strategies. Future directions emphasize novel biomaterials, tendon-bone interface healing, innovative seed cell cultivation, tendon growth microenvironment construction, and clinical translation of research outcomes.
    Conclusion: This bibliometric analysis reveals the core research directions and potential pathways in tendon tissue engineering, providing a reference for future studies.
    Keywords:  Bibliometrics; Development trends; Historical evolution; Research hotspots; Tendon tissue engineering
    DOI:  https://doi.org/10.1016/j.reth.2025.04.009
  33. World J Gastrointest Oncol. 2025 May 15. 17(5): 102282
    Global research trends in endoscopy applications in submucosal tumor: A bibliometric analysis of studies published from 2010-2024.
    Ke-Xin Lin, Yan Liu, Li Wang, Pei-Rong Xu, Zu-Qiang Liu, Li-Yun Ma, Jia-Jia Lin, Tao Tan, Ping-Hong Zhou, Hao Hu.
       BACKGROUND: Submucosal tumors (SMTs) are rare conditions frequently encountered in clinical endoscopic practice. With advancements in endoscopic technology over the past decade, endoscopic management of SMTs has emerged as a significant research area.
    AIM: To examine developments in this field, compare contributions from different countries, institutions, and authors, and identify potential research hotspots.
    METHODS: Relevant publications on the endoscopic management of SMTs between January 2010 and June 2024 were extracted from the Web of Science Core Collection database. Microsoft Excel, VOSviewer, and CiteSpace were used to analyze publication trends and visualize key results.
    RESULTS: Overall, 339 publications by 1840 authors from 31 countries/regions were included. Surgical Endoscopy and Other Interventional Techniques was the most prominent journal in the field (62 articles, 18.29%). Most research was conducted in China (n = 212), followed by Japan (n = 47), and the United States (n = 28). Fudan University (China) was the most active institution, and Professor Zhou published the most papers (n = 27) with had the highest citation count (n = 1167). Emerging research topics include full-thickness resection devices, defect closure, and cooperative surgery.
    CONCLUSION: The endoscopic management of SMTs has advanced rapidly over the past 14 years. However, national and regional development disparities persist, with limited high-level studies and weak inter-institutional and international collaboration. Device-assisted techniques and combined surgical endoscopic resections are emerging as key areas for future research.
    Keywords:  Bibliometrics; Endoscopic resection; Global; Publications; Submucosal tumors
    DOI:  https://doi.org/10.4251/wjgo.v17.i5.102282
  34. Front Microbiol. 2025 ;16 1577597
    Current status and trends in the study of intestinal flora in cognitive disorders: a bibliometric and visual analysis.
    Qi Zhang, Zhenmei Gao, Yunqing Deng, Xiangqing Xu, Wenyu Sun, Rui Liu, Tianao Zhang, Xilei Sun.
       Background: Cognitive impairment is a decline in people's ability to think, learn, and remember, which has some impact on an individual's daily activities or social functioning. Microbial toxins and metabolites from dysregulated gut microbiota directly interact with the intestinal epithelium. This interaction triggers neuroinflammation and neurodegeneration in the central nervous system, ultimately impairing cognitive function. It has been found that modulation of gut flora can be an effective intervention to improve cognitive dysfunction. This study is the first to summarize and outline the global research status and trends in this field from a bibliometric perspective, providing reference and guidance for future research in this field.
    Methods: Based on the Web of Science Core Collection (WoSCC) database, Literature on gut flora and cognitive impairment published between 1999-2025 was searched. Bibliometric analysis was performed using VOSviewer and CiteSpace software to analyze the data on countries, institutions, authors, journals, keywords, citations, and to generate visual maps.
    Results: A total of 1,702 pieces of related literature were retrieved. The overall trend of publication is increasing. China has published the largest number of papers, and Huazhong University of Science & Technology and Kim, Dong-Hyun were the institutions and individuals with more publications. The most frequently cited journal is SCI REP-UK. The most frequent keywords are gut microbiota, followed by Alzheimer's disease, cognitive impairment, Brain, oxidative stress and Inflammation.
    Conclusion: In recent years, the research application of gut flora in the treatment of cognitive impairment has made remarkable progress. Oxidative stress and inflammatory response have become the main research hotspots for gut flora to improve cognitive impairment in patients. The gut-brain axis plays an important role in the study of the mechanism of action. Short-chain fatty acids are the focus of research on gut microbial metabolism. Fecal microbial transplantation technology is increasingly being used as an emerging method for the application of intestinal flora. Modifying the gut flora by modifying diet and exercise may be an effective strategy to prevent and improve cognitive dysfunction in the future. Future studies may focus more on gender differences in the role of gut flora in the modulation of cognitive function.
    Keywords:  bibliometrics; cognitive impairment; fecal microbiota transplantation techniques; gut-brain axis; intestinal flora; short-chain fatty acids
    DOI:  https://doi.org/10.3389/fmicb.2025.1577597
  35. Aten Primaria. 2025 Jun 06. pii: S0212-6567(25)00010-1. [Epub ahead of print]57(9): 103224
    Scientific production in primary health care in Latin American and Caribbean Countries (1980-2024): A web of science perspective.
    Muhammet Damar, Thiago Gomes da Trindade, Andrew D Pinto.
       OBJECTIVES: To analyze the scientific production of primary care research in Latin American and Caribbean (LAC) countries from 1980 to 2024 and to provide recommendations for improvement.
    DESIGN: Observational, machine learning-based bibliometric study.
    DATA SOURCES: Review and research articles indexed in the Web of Science database.
    SELECTION OF STUDIES: Bibliometric analysis was performed on data from 33 LAC countries, retrieved from the Web of Science as of April 15, 2024.
    DATA EXTRACTION: For each record, data on the journal, year of publication, article title, abstract, keywords, authors, affiliations, countries, cited sources, cited first authors, and references were extracted for bibliometric and text mining analyses. We used a form of machine learning, Latent Dirichlet Allocation topic modeling, to identify the key topics of research.
    RESULTS: LAC countries contributed only 0.83% of the global literature on primary health care, with just 0.98% of this output comprising research and review articles. The majority of research originated from Brazil, Mexico, Colombia, and Chile, while many LAC countries produced little to no output. LAC countries frequently collaborated with the United States, Spain, Canada, and England. Research topics in the region predominantly focused on cancer, obesity, COVID-19, nutritional disorders, and food safety within the primary health care field.
    CONCLUSIONS: The findings highlight significant potential for growth in primary health care research in LAC countries. Strengthening individual and collective strategies to build research capacity and fostering collaborations with global academic networks are recommended to enhance research output and impact.
    Keywords:  América Latina; Aprendizaje automático; Atención primaria de salud; Bibliometrics; Bibliometría; Evaluación de la investigación en salud; Health research evaluation; Latin America; Machine learning; Primary health care
    DOI:  https://doi.org/10.1016/j.aprim.2025.103224
  36. Clin Exp Rheumatol. 2025 Jun 05.
    Research trends and hotspots on gut microbiota in rheumatoid arthritis: a bibliometric analysis from 2004 to 2024.
    Zesen Zheng, Xiaoyang Liu, Youao Zhang, Huihui Zhang, Shixian Chen, Junqing Zhu.
       OBJECTIVES: Rheumatoid arthritis (RA) is an autoimmune condition linked to alterations in the gut microbiota. This study aims to conduct a comprehensive analysis of the literature on gut microbiota and RA over the past 21 years through bibliometric methods, thereby identifying emerging trends and hotspots, and providing insights for the precision treatment of RA.
    METHODS: The authors analysed articles on gut microbiota in RA published from 2004 to 2024 based on the Web of Science Core Collection database. Bibliometric methods employed tools such as CiteSpace, VOSviewer, and COOC to conduct visual analyses of countries, institutions, references, and keywords.
    RESULTS: 1,267 articles from 80 countries led by China and the United States were included. A notable increase in annual publications reflects the growing interest in this field. Simultaneously, contributions and cooperation of institutions in the field are discussed. Furthermore, co-citation and keyword analysis revealed four research hotspots: 1. specific gut microbiota like Prevotella copri modulating immune responses in RA; 2. dietary interventions regulating gut microbiota as therapeutic approaches for RA; 3. high-throughput sequencing technologies enabling microbiome analysis for diagnostic RA; and 4. probiotics and plant-derived bioactive compounds serving as promising adjunctive therapies for RA management.
    CONCLUSIONS: The relationship between RA and gut microbiota has been extensively studied. The hotspot of future research may be to further study the pathological mechanism of gut microbiota in RA and how to improve the symptoms of RA patients through dietary therapy and adjustment of the homeostasis of gut microbiota.
    DOI:  https://doi.org/10.55563/clinexprheumatol/3899sf
  37. Skin Appendage Disord. 2025 May 08. 1-16
    Bibliometric Analysis in Hyperhidrosis: Recent Publication Trends from 2015 to 2025.
    Aditya Joshi, David J Griego, Lauren Gawey, Raveena Ghanshani, Khiem A Tran, Jennifer L Hsiao, Vivian Y Shi.
       Introduction: Hyperhidrosis is a chronic dermatologic condition that significantly impacts quality of life. While research has expanded in recent years, bibliometric analyses exploring publication trends remain limited. This study examined the 100 most-cited articles from 2015 to 2025 to assess research priorities.
    Methods: A Scopus search was conducted on January 2, 2025, using the terms "hyperhidrosis", "primary hyperhidrosis", "secondary hyperhidrosis", and "excessive sweating". Non-English, abstract-only, and non-hyperhidrosis focused articles were excluded. Two reviewers screened and identified the 100 most-cited publications. Data were analyzed for publication year, authorship, country, study design, journal, and topic focus. The Oxford Centre for Evidence-Based Medicine Level of Evidence (LoE) framework was used to assess study quality.
    Results: The majority (76%) of highly cited articles were published between 2015 and 2019. Randomized controlled trials (20%), cohort studies (18%), and case-control studies (16%) were the most common study types. Using LoE assessment, 33% of studies were level 1 (high-quality evidence). Research on treatments (55%) dominated, followed by quality of life (12%) and outcome measures (11%). The USA led in publication output.
    Conclusion: This bibliometric analysis identifies evolving research priorities toward minimally invasive treatments and patient-centered outcomes, providing direction for future research and improvements in clinical practice.
    Keywords:  Bibliometric analysis; Excessive sweating; Hyperhidrosis; Primary hyperhidrosis; Publication trends; Secondary hyperhidrosis
    DOI:  https://doi.org/10.1159/000545767
  38. Plast Reconstr Surg Glob Open. 2025 Jun;13(6): e6870
    Quantifying Research Productivity From First-year US Integrated Plastic Surgery Residents After USMLE Step I Pass/Fail Conversion.
    Andrew Hannoudi, Benjamin A Sarac, Jeffrey E Janis.
       Background: Matching into integrated plastic surgery residency is extremely competitive. Although previous studies have examined the research output of matched residents, a thorough investigation of their types of publications, authorship trends, and citation metrics has not been performed following the transition of Step 1 to a pass/fail system. Identifying trends among successful matriculants may guide medical students toward successful preparation for the current application process.
    Methods: Research profiles for 213 first-year US integrated plastic surgery residents from the 2024-2025 cohort were analyzed using Scopus. Variables included publication count, number of first-author publications, types of publications, and journal impact factor. Residents were tiered into quartiles based on the amount of National Institutes of Health (NIH) funding received by their programs' associated universities or hospitals. Univariate regression analysis was performed to determine the relationship between NIH tiers and various research output characteristics.
    Results: The 2024-2025 integrated plastic surgery residency cohort had a median of 5 publications. First authorship contribution was evident in 32.6% of all publications, and 59.2% of all publications discussed plastic surgery-related topics. Original research articles were 66.4% of the studies. Journals published in had a median impact factor of 2.1. No significant differences were observed between NIH funding tiers and any of the research output characteristic variables.
    Conclusions: This study may guide future US integrated plastic surgery applicants toward success in the match by offering a qualitative and quantitative overview of the current landscape of research output characteristics for successful matriculants.
    DOI:  https://doi.org/10.1097/GOX.0000000000006870
  39. Discov Oncol. 2025 Jun 11. 16(1): 1055
    Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis.
    Ziqian Wang, Xiaodu Xie, Ze Wang, Peng Tang, Jian Chen, Jing Xu, Junying Zhang, Haiyang Xiao, Chongliang Zheng, Jun Jiang, Qiuli Liu, Weihua Lan.
       BACKGROUND: Molecular targeted therapies have shown considerable efficacy in treating metastatic renal cell carcinoma (mRCC). However, many patients still experience tumor recurrence or metastasis due to drug resistance. Despite extensive research on resistance mechanisms, there is a lack of comprehensive bibliometric studies examining the overall characteristics of targeted therapy resistance in renal cell carcinoma.
    MATERIALS AND METHODS: Publications on resistance to targeted therapy in renal cell carcinoma were identified from the Web of Science Core Collection (WoSCC) from June 2004 to November 2024. The English-language literature was analyzed using bibliometric tools, including VOSviewer and CiteSpace, to examine publication trends, active countries/regions, key authors, and institutions. Keyword analysis, co-citation mapping, and gene identification were conducted to uncover research trends and focal points.
    RESULTS: A total of 1081 publications were identified, with the United States, China, and Italy as the top contributing countries. Prominent institutions included the Cleveland Clinic, the Sloan Kettering Cancer Center, the MD Anderson Cancer Center, Fudan University, and Huazhong University of Science and Technology. Camillo Porta was a prolific author, and Brian I. Rini was among the most highly cited. The journal Cancers published the most papers in this field, and the Journal of Clinical Oncology was the most co-cited. Key research topics included the "tumor microenvironment" and "combination therapy". A comprehensive analysis of publications related to "the tumor microenvironment" reveals that "renal cancer stem cells" and "epithelial-mesenchymal transition" have been identified as key terms strongly associated with therapeutic resistance mechanisms in targeted cancer treatments. In-depth analysis of the regulatory molecules and molecular mechanisms in the literature highlighted the roles of microRNA and the synergistic effects between anti-PD-L1/PD-1 and targeted drugs.
    CONCLUSIONS: Bibliometric analysis of research on molecular targeted therapy resistance in renal cell carcinoma revealed a clear trajectory and rapidly increasing trend in this field. The impact of the tumor microenvironment, particularly the roles of renal cancer stem cells and epithelial-mesenchymal transition, has garnered significant attention. Additionally, the combination of anti-PD-L1/PD-1 and targeted drugs, as well as the involvement of miRNA, have emerged as key areas of focus. As understanding of this field deepens, future research is expected to uncover novel therapeutic targets and more effectively overcome the challenges of targeted therapy resistance in renal cell carcinoma, ultimately improving patient outcomes.
    Keywords:  Bibliometrics; Combination therapy; Drug resistance; Molecular targeted therapy; Renal cell carcinoma; Tumor microenvironment
    DOI:  https://doi.org/10.1007/s12672-025-02772-0
  40. Med Sci Law. 2025 Jun 12. 258024251348722
    Visual analysis of hotspots and evolutionary trends in the field of postmortem interval estimation.
    Chengqiang Du, Yehui Lv.
      Purpose: Through a visual analysis of the literature on postmortem interval estimation research collected in the Web of Science database, this study aims to explore the development process, research hotspots, and technical approaches in this field, providing a reference for scholars and professionals in related fields. Methods: It retrieves English-language articles related to postmortem interval estimation published in the Web of Science Core Collection from its inception until December 31, 2023, that meet the inclusion criteria. The study calculates the annual number of publications and citations and analyzes the trends. Based on these annual publication volumes, a second search is conducted for the period during which the number of publications in this field exceeded 100 per year, specifically from January 1, 2014, to December 31, 2023. CiteSpace 6.2.R4 software is used to perform a visual analysis of the second set of retrieved documents. Results: The first search retrieved 1778 articles related to postmortem interval estimation research. The second search retrieved 1265 articles, with an average annual growth rate of 6.84%. Based on the publication trend line for this period, it is predicted that approximately 150 articles will be published in this field in 2024. Conclusion: In the future, the development of postmortem interval estimation will likely remain in a steady phase. Interdisciplinary interactions and constraints still exist. The future direction may focus on using multiomics approaches, combined with advancements in artificial intelligence, to establish comprehensive data models for more accurate postmortem interval estimation.
    Keywords:  Postmortem interval; bibliometrics; future trends; research hotspots and evolution; visual analysis
    DOI:  https://doi.org/10.1177/00258024251348722
  41. Medicine (Baltimore). 2025 Jun 06. 104(23): e42033
    Bibliometric insights in surgical treatment of secondary hyperparathyroidism: Research status, hotspots, and global trends.
    Yanhao Ran, Xun Zheng, Pengyu Li, Yujie Zhang, Tianfeng Xu, Yuanyuan Fan, Tao Wei.
      Secondary hyperparathyroidism (SHPT) is mainly seen in advanced chronic kidney failure, and its main clinical feature is an increase in the synthesis and secretion of parathyroid hormone. Surgical treatment is typically considered when the parathyroid hormone level remains consistently above 800 pg/mL and is accompanied by hypercalcemia or when conservative treatment is ineffective. Secondary hyperparathyroidism may manifest as bone and joint pain, mental abnormalities, skin itching, and hyperpigmentation. There are 3 main surgical approaches for parathyroidectomy (PTX): subtotal PTX (sPTX), total PTX with parathyroid auto-transplantation (TPTX + AT) and total PTX without parathyroid auto-transplantation (TPTX). Complications that may arise after PTX include unsatisfactory surgical outcomes, recurrence, bone mineral disease and hungry bone syndrome. In this study, nearly 3 decades of scientific articles about the surgical treatment of SHPT were analyzed and summarized to gain a better understanding by using bibliometric method. 1389 publications from 1990 and 2023 were included in the WoS database through systematic retrieval. The general information was characterized, and the developmental skeleton and research frontiers were explored. CiteSpace was used to evaluate and visualize the results. 1389 publications were included in the results, and the frequency of citations was 15,688. The top 5 countries for the number of literatures published were USA, China, Japan, Italy, and Germany; The top 5 countries for literature centrality were USA, France, England, Romania, and Sweden. There are 10 institutions which the number of literatures from each institution was more than 20. The top 10 institutions all scored 0.04 or above for their Centrality score, which indicates that research in this area was relatively intensive and that there is much co-operation between institutions. The most cited authors were mainly from Japan and USA. Journals, such as Surgery World J Surg, J Clin Endocr Metab, Kidney Int, had greater influence in this field. Keyword analysis results showed that research mainly focuses on parathyroid hormone, surgery, chronic renal failure and subtotal parathyroidectomy. This bibliometric study provides a comprehensive analysis of global productivity, collaboration, and research hotspots within the Surgical treatment of secondary hyperparathyroidism, which will aid in directing research toward endoscopic thyroidectomy in the coming years.
    Keywords:  bibliometrics; parathyroid gland; secondary hyperparathyroidism; surgery; treatment
    DOI:  https://doi.org/10.1097/MD.0000000000042033
  42. Trop Anim Health Prod. 2025 Jun 11. 57(5): 261
    The importance of sheep genetics and diversity: a bibliometric review.
    Concepta McManus, Daniel Pimentel, Vinícius Silva Junqueira, Felipe Pimentel, Vanessa Peripolli.
      This study aims to provide a comprehensive analysis of published research on sheep genetics and diversity by examining temporal publication trends, identifying thematic patterns through keyword analysis, and exploring citation and collaboration networks. In addition to mapping the evolution of scientific interest in this field, the study evaluates the influence of these research trends on policy development and technological innovation, including patenting activity. By integrating bibliometric indicators with qualitative insights, the study offers a detailed understanding of how research in sheep genetics contributes to the conservation and strategic use of genetic resources. A search of the Scopus database (Elsevier) retrieved over 16,000 papers from more than 1,700 journals. Our findings indicate that the research on this topic is predominantly concentrated in the United States, China, and Australia, with limited data available from countries in Central Africa. This geographical distribution is reflected in funding sources and author affiliations. Major funding sources include China, the European Commission, and Brazil. Leading research institutions are primarily based in Australia, Europe, and New Zealand. More studies are needed in central Africa to address the regional gaps. Small Ruminant Research currently stands as the leading journal in sheep genetics and diversity, closely followed by Animals and Animal Production Science. In the past, however, the Journal of Animal Science and Animal Genetics held more prominence. There is considerable variability in journal impact, with Indian publications generally exhibiting lower impact metrics. Research themes primarily focus on veterinary concerns, including disease resistance, reproduction, and adaptation to climate change. While collaborations between international and academic-corporate partners can enhance the impact of research, the overall level of collaboration remains low. The study also addresses discussions related to policy and patenting, highlighting gaps such as the limited application of findings to local policymaking contexts. Genetic diversity in farm animals is key for resilience, innovation, and sustainability in global food systems. However, there is a significant lack of studies from Central Africa. Major research funding is provided by China, the European Commission, and Brazil, while institutions from Australia, Europe, and New Zealand play a key role. Innovative technologies, such as genomics, are showing a growing research focus. This study highlights the pressing need for diverse research efforts and international collaborations to effectively address global livestock genetics issues.
    Keywords:  Authorship; Citations; Impact; Patents; Public policies
    DOI:  https://doi.org/10.1007/s11250-025-04503-7
  43. J Pharm Bioallied Sci. 2025 May;17(Suppl 1): S169-S171
    A Bibliometric Analysis of Naturopathy Treatment Modalities for Diabetes Mellitus.
    Himel Mondal, Satyalakshmi Komarraju, D Sathyanath, Shrikanth Muralidharan, Rintu K Gayen.
      Diabetes mellitus (DM) continues to pose a significant global health challenge, leading to increased interest in naturopathy as a complementary therapeutic approach. This bibliometric analysis examines global research output on naturopathy in the context of DM to identify trends, collaborations, and knowledge gaps. A total of 73 publications from 1983 to 2024 were retrieved from the Web of Science database and analyzed for year-wise distribution, geographic and institutional contributions, subject areas, and publishers. The analysis revealed a notable rise in publications in 2021, with China emerging as the leading contributor, followed by South Korea and the United States. Prominent research themes included acupuncture, diabetes, and insulin resistance. Leading publishers in this field were Lippincott Williams & Wilkins, Elsevier, and Springer Nature. Despite the global rise in research, India's participation remains limited. The study highlights the need for more evidence-based investigations to support the integration of naturopathy into mainstream diabetes management.
    Keywords:  Acupuncture; bibliometrics; diabetes mellitus; insulin resistance; naturopathy
    DOI:  https://doi.org/10.4103/jpbs.jpbs_486_25
  44. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 12.
    Gender- and discipline-specific bibliometric analysis of elite biomedical scientists: how is pharmacology performing?
    Louisa Christin Fox, Roland Seifert.
      In two recent studies ( https://pubmed.ncbi.nlm.nih.gov/38652280/ ; https://pubmed.ncbi.nlm.nih.gov/38864907/ ) we bibliometrically analyzed Nobel laureates and top pharmacologists in Germany and found massive underrepresentation of women. In this follow-up study, using www.research.com as a source, gender relations in elite biomedical research were analyzed at a global level. A total of 9791 researchers from 29 countries from the main category of biology and biochemistry were analyzed. The pooled global data set results in a proportion of 14.9% women among the elite researchers; in the individual countries, it ranged from 31.2% (Italy) to 0% (Egypt, Iran, Nigeria; however, only very small sample sizes here). Pharmacology is characterized by lower bibliometric indices than biology and biochemistry; i.e., pharmacologists have a less prominent international perception in science than other fields. Pharmacologists must generate more output to achieve a similar status to other disciplines. The analysis using common bibliometric parameters and the newly defined h/P-Index revealed that women in biology and biochemistry globally have a significantly higher h/P-Index than men-they are characterized by a more consistent scientific quality. Women are "doing well" in bibliometric analyses, achieving a good position in science measured by bibliometric parameters, despite the strong underrepresentation in elite science. In conclusion, caution must be exerted when comparing disciplines and countries bibliometrically because they have different cultures, and women are differentially represented in elite research in various countries.
    Keywords:  Bibliometric comparison; Elite research; Gender equality; Gender research; H-Index
    DOI:  https://doi.org/10.1007/s00210-025-04360-z
  45. Front Oncol. 2025 ;15 1562539
    Knowledge mapping of global trends in DNA damage repair-related breast cancer research: a bibliometric study.
    Yajing Huang, Shumei Wei, Kaimin Hu, Xueping Xiang.
       Background: Breast cancer remains one of the leading causes of cancer-related morbidity and mortality among women worldwide. Recent advancements in our understanding of DNA damage repair (DDR) mechanisms have shed light on their specific role in the pathogenesis, progression, treatment resistance, and prognosis of breast cancer. In this study, we conducted a bibliometric study to map the global trends in DDR-related breast cancer research.
    Methodology: A search of publications on DDR in breast cancer from 1990 to 2024 was conducted using the Web of Science Core Collection. A comprehensive bibliometric analysis of the data was performed using CiteSpace, VOSviewer, and Bibliometrix. Additionally, for clinical trial data, the databases ClinicalTrials.gov (https://www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (https://trialsearch.who.int) were queried.
    Results: The results revealed a continuous and steady growth in the number of articles published in this area over the past three decades and showed that the USA had produced the highest number of publications in this field, while Harvard University had published the largest number of articles. Jonkers, Jos was found to be the most published author, with 39 documents. Analysis of the journals showed that Cancer Research ranked as the most published journal, while Nature was the most cited. Combined with the keyword co-occurrence analysis and co-citation analysis, it emerged that "Targeting the DNA repair defect as a therapeutic strategy", published in Nature (IF = 64.8) in 2005, had accumulated 529 local citations, indicating that research topics have focused on treatment regimens. For clinical trials, 124 studies were initially sourced-108 from ClinicalTrials.gov and 16 from ICTRP. After repetitive and correlation-based screening, 43 trials specifically addressing 13 different DDR-related drugs in breast cancer were included.
    Conclusion: Overall, this study provides valuable insights into the current research achievements, latest advancements, and emerging global trends in DNA damage repair-related breast cancer research. With sustained clinical focus, more high-quality investigations combining DDR inhibitors with other treatment modalities are needed.
    Keywords:  CiteSpace; DNA damage repair; VOSviewer; bibliometric study; breast cancer; global trends
    DOI:  https://doi.org/10.3389/fonc.2025.1562539
  46. Healthcare (Basel). 2025 May 29. pii: 1293. [Epub ahead of print]13(11):
    Hotspots and Trends in Research on Early Warning of Infectious Diseases: A Bibliometric Analysis Using CiteSpace.
    Xue Yang, Hao Wang, Hui Lu.
      Background: Emerging and re-emerging infectious diseases (EIDs and Re-EIDs) cause significant economic crises and public health problems worldwide. Epidemics appear to be more frequent, complex, and harder to prevent. Early warning systems can significantly reduce outbreak response times, contributing to better patient outcomes. Improving early warning systems and methods might be one of the most effective responses. This study employs a bibliometric analysis to dissect the global research hotspots and evolutionary trends in the field of infectious disease early warning, with the aim of providing guidance for optimizing public health emergency management strategies. Methods: Publications related to the role of early warning systems in detecting and responding to infectious disease outbreaks from 1999 to 2024 were retrieved from the Web of Science Core Collection (WoSCC) database. CiteSpace software was used to analyze the datasets and generate knowledge visualization maps. Results: A total of 798 relevant publications are included. The number of annual publications has sharply increased since 2000. The USA produced the highest number of publications and established the most extensive cooperation relationships. The Chinese Center for Disease Control & Prevention was the most productive institution. Drake, John M was the most prolific author, while the World Health Organization and AHMED W were the most cited authors. The top two cited references mainly focused on wastewater surveillance of SARS-CoV-2. The most common keywords were "infectious disease", "outbreak", "transmission", "virus", and "climate change". The basic keyword "climate" ranked the first and long duration with the strongest citation burst. "SARS-CoV-2", "One Health", "early warning system", "artificial intelligence (AI)", and "wastewater-based epidemiology (WBE)" were emerging research foci. Conclusions: Over the past two decades, research on early warning of infectious diseases has focused on climate change, influenza, SARS, virus, machine learning, warning signals and systems, artificial intelligence, and so on. Current research hotspots include wastewater-based epidemiology, sewage, One Health, and artificial intelligence, as well as the early warning and monitoring of COVID-19. Research foci in this area have evolved from focusing on climate-disease interactions to pathogen monitoring systems, and ultimately to the "One Health" integrated framework. Our research findings underscore the imperative for public health policymakers to prioritize investments in real-time surveillance infrastructure, particularly wastewater-based epidemiology and AI-driven predictive models, and strengthen interdisciplinary collaboration frameworks under the One Health paradigm. Developing an integrated human-animal-environment monitoring system will serve as a critical development direction for early warning systems for epidemics.
    Keywords:  CiteSpace; bibliometric analysis; early warning; infectious diseases
    DOI:  https://doi.org/10.3390/healthcare13111293
  47. Regen Ther. 2025 Jun;29 587-599
    Bibliometric analysis of hydrogels in bone regeneration: Research trends and future perspectives.
    Alimujiang Abudourousuli, Aikebaierjiang Aisaiti, Kan Jiang, Shalayiding Aierxiding, Kutiluke Shoukeer, Ran Han, Aikeremujiang Muheremu.
       Objective: To analyze the research status and development prospects of hydrogels in the field of bone regeneration based on bibliometric methods.
    Methods: In the Web of Science Core Collection database, a total of 1382 representative articles related to the application of hydrogels in bone regeneration were selected as of the end of 2023. Utilizing the tools VOSviewer and CiteSpace, an in-depth bibliometric visualization analysis was conducted to reveal the countries, authors, core literature, and journals that are highly productive in this field. Additionally, the research trends and development prospects within this area were analyzed.
    Results: This study uses VOSviewer and CiteSpace to analyze 1382 highly cited articles on bone regeneration and materials science, revealing key trends and the evolution of the field. The United States, China, South Korea, Germany, the UK, and Japan are the leading countries in scientific output, with strong collaboration networks. Major research institutions, particularly in China and Japan, focus on hydrogels for bone regeneration. Top journals include International Journal of Biological Macromolecules and Acta Biomaterialia. Key authors include Timothy E. L. Douglas, known for developing mineralization-enhanced hydrogels, and Robert E. Guldberg, focused on growth factor delivery systems. The field has shifted from simple filling materials to multifunctional composites, with advancements in gene editing, signaling molecules, and bone regeneration drugs. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimizing biodegradability and biocompatibility. Multifunctional composite hydrogels are expected to become the go-to materials for clinical bone repair.
    Conclusion: Advancements in technology have transformed hydrogels from simple fillers to multifunctional composites, playing a crucial role in bone regeneration. Future trends include smart hydrogels, 3D printing, bioactive factor integration, cell engineering, and optimized biodegradability and biocompatibility. These developments indicate hydrogels will become the preferred material for clinical bone defect repair, significantly enhancing bone tissue repair and regeneration.
    Keywords:  Bibliometrics; Biomaterials; Bone regeneration; Hydrogels; Orthopedics; Tissue engineering
    DOI:  https://doi.org/10.1016/j.reth.2025.04.006
  48. Medicine (Baltimore). 2025 Jun 06. 104(23): e42612
    Global knowledge mapping and emerging research trends in non-coding RNAs related to animal and plant male sterility: A visual analysis of CiteSpace maps.
    Mingzhao Zhang, Baojun Ju, Xiangyu Wang, Shuxi Zhou, Haobin Zhao, Zu Long Wang, Xiao Li.
      Animal and plant male sterility is a complex and closely studied phenomenon that significantly impacts species survival and reproduction. Advances in biotechnology and molecular biology have deepened our understanding of gene expression regulation, particularly the role of noncoding RNAs (ncRNAs). This study aims to systematically review and analyze the published literature on ncRNAs in relation to both animal and plant sterility using bibliometric methods. A bibliometric analysis was conducted with CiteSpace 6.2.R6, Scimago Graphica, VOSviewer 1.6.18, and Microsoft Excel 2016 to identify research hotspots, key developments, and emerging trends. Data were retrieved from the Web of Science Core Collection on March 3, 2024, covering publications from 2005 to 2023. The analysis revealed a consistent increase in annual publications on ncRNA research in both plant and animal fields, with China and the United States leading in publication volume. Notable scholars include Professor Abu-Halima, a prominent figure in ncRNA research related to animal male sterility, and Professor Meyers, a key contributor to plant male sterility research. Journals such as PLoS ONE serve as major platforms for disseminating findings on animal male sterility, while The Plant Cell plays a similar role for plant male sterility. Analysis of cited literature and keyword trends highlighted significant themes, including gene regulation and the application of novel technologies. At present, new technologies, model organisms, and gene regulation remain major research hotspots. Meanwhile, disease diagnosis, disease treatment, and crop improvement are emerging as important directions for future research.
    Keywords:  RNA sequencing; gene regulation; male sterility; model organism; ncRNA
    DOI:  https://doi.org/10.1097/MD.0000000000042612
  49. J Multidiscip Healthc. 2025 ;18 3233-3255
    A Systematic Bibliometric Analysis of Cardiovascular Disease Risk in Obesity (2014-2024).
    Hang Yang, Tao Zhang, Dongyang Wang, Edmund Loi, Qixiang Geng, Baoling Wu, Xi Wang, Rongjiang Cai.
       Background: Obesity, as a global chronic disease, is causing an increasing risk of cardiovascular disease. This study used bibliometrics to synthesize and analyze publications related to obesity and cardiovascular risk from 2014 to 2024. It aimed to clarify the current status of research, predict future trends, and provide a scientific basis for prevention and treatment.
    Methods: In this study, we used bibliometrics online analysis platform, Citespace (version 6.3.R1, LLR algorithm) and VOSviewer (version 1.6.20) software to analyze the co-occurrence network analysis of publications related to cardiovascular risk of obesity in worldwide for countries, institutions, authors, and journals from January 2014 to September 2024, and keyword co-occurrence, clustering, and burst analysis were performed to reveal research trends and hotspots.
    Results: A total of 1492 articles related to cardiovascular risk in obesity were selected for this study, and in terms of the number of publications showed a steady increase over time. Based on keyword clustering analysis, the field can be summarized into two research themes: the field of the relationship between health indicators such as BMI, waist circumference, cardiovascular disease, and the field of metabolism and obesity-related issues. According to the keyword burst analysis, the keywords cholesterol, oxidative stress, non-alcoholic fatty liver disease, and ratio to height became prominent and will be the main research hotspots in the future.
    Conclusion: In recent years, there has been a rapid increase in cardiovascular risk research in obese patients. This article reveals the remarkable progress and dynamic trends in this field, providing strong support for exploring new directions, as well as laying a data foundation for public health policy development and interdisciplinary collaboration. Future research should prioritize focusing on mechanism exploration and clinical application of novel drugs to promote health improvement.
    Keywords:  bibliometric study; cardiovascular disease; knowledge mapping; obesity; risk
    DOI:  https://doi.org/10.2147/JMDH.S504022
  50. Data Brief. 2025 Jun;60 111633
    Bibliometric insights into mobile money and data trends.
    Thi Thuy Hang Vu.
      This data aims to analyze the intellectual structure of mobile money studies by examining bibliographic characteristics. A dataset of 165 documents from the Scopus database was used. This study explored various aspects, including annual publication counts, country coupling, source numbers, primary research areas, co-occurrence of keywords, bibliographic linkages between sources and documents, and co-citation patterns of references. Bibliographic network mapping techniques were applied to analyze the data. The analysis was performed using VOSviewer and the Bibliometrix R package, software tools for scientific mapping. The results showed four main themes of the mobile money dataset: mobile money in Africa, financial inclusion, electronic money, and digital financial services.
    Keywords:  Bibliometric analysis; Bibliometrix R package; Data trends; Mobile money; VOSviewer
    DOI:  https://doi.org/10.1016/j.dib.2025.111633
  51. J Psychiatr Ment Health Nurs. 2025 Jun 10.
    The Development of Violence Research in Psychiatric Nursing: A Bibliometric Perspective.
    Mustafa Durmuş, Deniz Pamuk, Yusuf Durmuş, Ayşin Çetinkaya Büyükbodur, Ayşe Okanlı.
       BACKGROUND: There is a growing emphasis on violence-related research in psychiatric nursing, with an annual increase rate of 2.12% in publications and the highest number of publications occurring in 2024. This trend underscores the escalating importance of addressing violence in mental health settings.
    AIM: This study aims to demonstrate the quantitative and qualitative features of violence publications in the field of psychiatric nursing from a bibliometric perspective. Web of Science was used during the research.
    METHODS: This study employed bibliometric analysis, a methodological approach for delineating the scope of information and assessing productivity within a specific domain. The data were searched with the keyword combination 'violence and psychiatric nursing', including studies published until December 2024, the study date, without a time limit.
    RESULTS: In this study, 464 violence research/reviews in the field of nursing were identified between 2001 and 2025, and the research was completed with 438 violence studies in line with the exclusion criteria. 1493 authors wrote 390 research and 48 review/systematic review articles, with an average of 22.14 citations for each publication. Most were published in 2024.
    DISCUSSION: There is an apparent increase in the involvement of psychiatric nurses in studies pertaining to violence. It is proposed that nursing professionals should undertake further research to investigate violence processes and develop ethically sound approaches to patients and healthy individuals, taking into account biopsychosocial factors.
    IMPLICATIONS FOR PRACTICE: These findings collectively suggest that while progress is being made in understanding and addressing violence in psychiatric nursing, there remains a critical need for ongoing research, policy development and practical interventions to ensure the safety and well-being of both nurses and patients in mental health settings.
    Keywords:  bibliometric; mental health nursing; psychiatry; violence
    DOI:  https://doi.org/10.1111/jpm.13182
  52. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 07.
    The Schmiedeberg Medal of the German Society for Experimental and Clinical Pharmacology and Toxicology: a biographical and bibliometric analysis of the 47 recipients from 1956 to 2024.
    Jessica Marie Steinert, Roland Seifert.
      The Schmiedeberg Medal, awarded by the German Society for Experimental and Clinical Pharmacology and Toxicology (DGPT), is the highest honour for excellent pharmacologists and has been awarded to 47 recipients until 2024. The first medal was awarded to Wolfgang Heubner in 1956, the most recent of our analysis to Franz Hofmann in June 2024. This is the first profound analysis of the prize winners: Most of the prize winners (63.83%) were born in Germany, and more than half (53.19%) came from academic families. Notably, only two women (4.26%), Edith Bülbring and Marthe Vogt, have received the award, although the presence of women in medicine and among members of the DGPT is on the rise. Almost 90% of the award winners studied medicine, and 29.79% spent part of their studies in Berlin. The award winners enjoyed exceptional quality of life and consistently surpassed the average life expectancy, with an average age of 86.26 years. On average, their careers spanned 50.65 years, with the Schmiedeberg Medal being awarded 20.74 years after the peak of their careers. Over time, the number of publications and productivity, co-authors, and senior authorships increased, while first authorships decreased. This shift reflects the growing importance of collaborative scientific work as opposed to solo endeavours. The overall publication productivity also increased during the observation period, with the Naunyn-Schmiedeberg's Archives of Pharmacology being the most prominent journal for these publications, although its influence decreased over time. The predominant language of publication was English, accounting for 72.28% of the articles, a trend that has increasingly replaced German since the 1970s. The most common research focus was the cholinergic and adrenergic systems. Thus, Schmiedeberg Medal recipients are an outstandingly productive group of scientists enjoying a long scientific career and a long high-quality life. In addition, Schmiedeberg Medal recipients encountered numerous societal and scientific challenges which they mastered excellently. The gender gap for this award is dramatic, reflecting the very low number of eligible female pharmacologists for this award.
    Keywords:  Bibliometric analysis; Prize winner analysis; Schmiedeberg Medal; Scientific award
    DOI:  https://doi.org/10.1007/s00210-025-04260-2
  53. Psychoradiology. 2025 ;5 kkaf013
    Mobile eye-tracking and neuroimaging technologies reveal teaching and learning on the move: bibliometric mapping and content analysis.
    Qi Li, Yafeng Pan.
      Mobile psychophysiological technologies, such as portable eye tracking, electroencephalography, and functional near-infrared spectroscopy, are advancing ecologically valid findings in cognitive and educational neuroscience research. Staying informed on the field's current status and main themes requires continuous updates. Here, we conducted a bibliometric and text-based content analysis on 135 articles from Web of Science, specifically parsing publication trends, identifying prolific journals, authors, institutions, and countries, along with influential articles, and visualizing the characteristics of cooperation among authors, institutions, and countries. Using a keyword co-occurrence analysis, five clusters of research trends were identified: (i) cognitive and emotional processes, intelligent education, and motor learning; (ii) professional vision and collaborative learning; (iii) face-to-face social learning and real classroom learning; (iv) cognitive load and spatial learning; and (v) virtual reality-based learning, child learning, and technology-assisted special education. These trends illustrate a consistent growth in the use of portable technologies in education over the past 20 years and an emerging shift towards "naturalistic" approaches, with keywords such as "face-to-face" and "real-world" gaining prominence. These observations underscore the need to further generalize the current research to real-world classroom settings and call for interdisciplinary collaboration between researchers and educators. Also, combining multimodal technologies and conducting longitudinal studies will be essential for a comprehensive understanding of teaching and learning processes.
    Keywords:  bibliometric analysis; ecologically valid education; mobile eye tracking; mobile fNIRS; portable EEG
    DOI:  https://doi.org/10.1093/psyrad/kkaf013
  54. Healthcare (Basel). 2025 May 27. pii: 1267. [Epub ahead of print]13(11):
    A Bibliometric Review of Person-Centered Care Research 2010-2024.
    Lai-Kun Tong, Hon-Lon Tam, Ai-Mei Mao.
      Background/Objectives: Person-centered care (PCC) has become a pivotal concept in healthcare. At present, no published studies have assessed the PCC field using bibliometric tools. This study aimed to identify hot spots, trends, and developmental trajectories within the PCC field. Methods: Publications related to PCC from 2010 to 2024 were extracted from the Web of Science core collection database and analyzed by the Bibliometrix package from RStudio. Results: A total of 5837 studies were analyzed. The analysis revealed steady growth in PCC research, with the United Kingdom, Australia, and the USA leading in publication numbers. Frequent keywords included patient-centered care, PCC, and qualitative research. The thematic shift from patient-centered care to PCC highlights a growing emphasis on individual healthcare needs and values. The evolution of research themes related to PCC has varied across different time periods, with communication, quality improvement, multimorbidity, and chronic disease remaining underdeveloped during 2020-2024, indicating that these themes are key focuses for future research. Emerging keywords over the past five years-value-based healthcare; deep learning; telehealth; and COVID-19-suggest new research directions. Conclusions: This study provides a detailed overview of the PCC research landscape, highlighting key areas of focus and identifying potential directions for future research. The findings suggest a dynamic field with a growing emphasis on individualized care and the integration of new methodologies and themes to address current healthcare challenges.
    Keywords:  bibliometrics; person-centered care; research trends; thematic evolution
    DOI:  https://doi.org/10.3390/healthcare13111267
  55. Healthcare (Basel). 2025 May 23. pii: 1224. [Epub ahead of print]13(11):
    Global Trends and Emerging Frontiers in Smoking and Smokeless Tobacco Research: A Bibliometric Analysis over the Past Decade.
    Saumya Richa, Sumaila Praveen, Ahmed A Albariqi, Shahabe Saquib Abullais, Syed Esam Mahmood, Awad Alsamghan, Rishi Kumar Bharti, Ghadah Khaled Bahamdan.
      Tobacco use remains a critical global health issue, with extensive research focusing on its impact on public health, particularly its strong association with oral cavity cancer. It is a leading cause of preventable disease and death worldwide, affecting millions each year. Despite increased awareness and regulatory measures, tobacco continues to pose significant challenges, prompting ongoing investigations into its health effects and related behaviors.
    OBJECTIVE: This study aims to conduct a bibliometric analysis of smoking and smokeless tobacco research from 2014 to 2024, focusing on identifying key research trends, influential contributors, emerging topics, and collaborative networks on a global scale.
    METHODS: A dataset of 2694 research papers from PubMed was analyzed using bibliometric tools. Keyword co-occurrence, authorship patterns, and institutional collaborations were mapped to reveal dominant themes and trends. Additionally, country-specific publications were examined to assess geographical contributions and emerging research frontiers.
    RESULTS: The analysis indicates a 7.3% annual increase in publications, with a peak in 2021 likely influenced by COVID-19. Research topics have shifted from traditional tobacco-related health impacts, such as lung cancer and cardiovascular diseases, to newer areas like e-cigarettes and social determinants of health. Strong international collaborations were noted, with the U.S., China, and Europe as dominant contributors. Emerging research frontiers include electronic nicotine delivery systems and strategies aimed at controlling tobacco-related health risks.
    CONCLUSION: This bibliometric study highlights significant growth in tobacco-related research over the past decade. Evolving trends reflect a shift toward newer tobacco products and public health challenges. These findings provide valuable insights for shaping future research agendas and informing global tobacco control policies.
    Keywords:  bibliometrics; e-cigarettes; oral health; risk factors; smokeless tobacco; smoking; tobacco
    DOI:  https://doi.org/10.3390/healthcare13111224
  56. Toxicol Ind Health. 2025 Jun 12. 7482337251349366
    Landscapes, highlights and trending topics of ferroptosis research in the liver: A bibliometric analysis.
    Xiangning Zhou, Jingjing Yu, Tianwei Sun, Ying Wang, Zhenyu Yao, Ling Gao.
      Ferroptosis, a form of programmed iron-dependent cell death, is associated with various liver pathologies. Recent studies have increasingly highlighted the crucial role of ferroptosis in liver function. This study aimed to explore the development of ferroptosis in liver diseases through bibliometric analysis. We retrieved the data from the Web of Science (WOS) Core Collection, then imported selected articles into VOSviewer, CiteSpace, and Microsoft Excel for knowledge mapping analysis. A total of 1,236 articles were included in this study, showing a steady increase in publications on ferroptosis in the liver over the past 11 years, with a significant surge in recent years. China emerged as a dominant contributor, accounting for 86% of global publications. Key institutions included Zhejiang University and Sun Yat-sen University. Zhang Feng from Nanjing Medical University was identified as the most prolific author. The journal Frontiers in Pharmacology published the most articles on this topic. High-frequency keywords included "ferroptosis," "cell death," "hepatocellular carcinoma," "oxidative stress," and "cancer." Our analysis provides insight into the leading countries, institutions, authors, and journals and it highlights recent research hotspots. As an emerging research field, studies on ferroptosis in the liver focused primarily on molecular mechanisms, pathways, and treatment strategies. Hepatocellular carcinoma remains a primary focus within ferroptosis research in the liver. In the future, therapies targeting ferroptosis may offer promising avenues for liver disease treatment.
    Keywords:  VOSviewer; bibliometrics; ferroptosis; hepatocellular carcinoma; liver
    DOI:  https://doi.org/10.1177/07482337251349366
  57. Discov Oncol. 2025 Jun 11. 16(1): 1054
    Immunoregulatory role of pulmonary microbiota in lung cancer: a bibliometric analysis.
    Huijun Jia, Yifan Gong, Hongyu Wei, Chengguang Zhao, Qiwei Zang, Constance Sat Lin Liew.
       BACKGROUND: This study systematically analyzes the research landscape of lung cancer and pulmonary microbiota from 2015 to 2024 using bibliometric methods.
    METHODS: The Web of Science Core Collection provided data analyzed to uncover key contributors, pivotal research hotspots, and evolving trends.
    RESULTS: Results revealed a significant shift in focus from infections and inflammation to immunotherapy, microbial biomarkers, and immune response modulation, reflecting interplay between pulmonary microbiota and immune regulation in tumorigenesis. Major contributors, including China and the United States, along with leading journals, have driven progress in this interdisciplinary field, highlighting microbial imbalance's involvement in tumorigenesis and immune modulation. The findings underscore the potential of pulmonary microbiota as therapeutic targets and immune modulators, particularly for improving immunotherapy outcomes.
    CONCLUSIONS: This study provides a comprehensive overview of the field, offering insights into its current status and future directions, and establishes a foundation for further exploration of personalized medicine and immune-centered therapies.
    Keywords:  Bibliometric analysis; Immunotherapy; Lung cancer; Microbial biomarkers; Pulmonary microbiota
    DOI:  https://doi.org/10.1007/s12672-025-02595-z
  58. Psychiatry Clin Psychopharmacol. 2025 Jun;35(2): 185-197
    Trends and Hotspots in Research on Exercise and Alzheimer's Disease: A Decade of Bibliometric Review on Prevention and Molecular Mechanisms.
    Xinge Yang, Keke Li, Yimin Zhang, Ruizhe Sun, Jingjing Yu.
      With the rapid acceleration of global aging, the prevalence of Alzheimer's disease (AD) continues to rise, exerting a profound impact on elderly individuals' physical health, lifestyle, and quality of life. Exercise has demonstrated significant research value and broad application potential in AD as a non-pharmacological preventive and therapeutic approach. This study aims to provide a bibliometric and visual analysis of research related to exercise and AD over the past decade. It seeks to identify research hotspots and development trends, explore the layers of research on exercise's impact on AD, and clarify its preventive effects and molecular mechanisms. The Web of Science Core Collection database was used as the data source for this study. A comprehensive search was conducted using the topic "exercise for Alzheimer's disease," covering the period from January 1, 2014, to August 31, 2024. CiteSpace and Python were employed to perform bibliometric and visual analyses on these publications, including assessments of publication trends, keyword co-occurrence, clustering analysis, timeline analysis, burst detection analysis, and the distribution and growth trends of molecular mechanisms related to exercise and AD. 1. Annual publication trends: 6134 articles were included in the analysis. The number of publications on exercise and AD increased steadily from 2014 to 2024 (β = 53.23,P < .001). 2. Keyword co-occurrence and clustering analysis: research on exercise and AD primarily focuses on themes related to cognitive decline, risk factors, exercise-induced energy metabolism, exercise intensity, and molecular mechanisms. 3. Keyword timeline and burst analysis: epidemiological and clinical studies maintained high activity levels in the early and mid-stages of the research timeline, whereas molecular-level studies exhibited increased activity in the later stages. 4. Molecular mechanisms distribution: analysis of molecular mechanisms reveals that amyloid-beta deposition and oxidative stress remain the predominant research areas. Meanwhile, research on neuroinflammation, brain-derived neurotrophic factor (BDNF), Tau pathology, and other related mechanisms has been further explored. The findings demonstrate a progressive shift in research focus from general epidemiological patterns to more in-depth investigations of molecular biological mechanisms. Exercise has been shown to play a preventive role at the clinical level by improving cognitive function and mitigating risk factors and at the molecular level by modulating key pathological mechanisms, including β-amyloid deposition, oxidative stress, BDNF, tau pathology, and others. Through the coordinated regulation of multiple targets and pathways, exercise exerts a neuroprotective effect against AD.
    DOI:  https://doi.org/10.5152/pcp.2025.241016
  59. Comput Inform Nurs. 2025 Jun 04.
    The Use of Artificial Intelligence in Nursing Science: Emerging Trends Through Bibliometric Analysis.
    Songül Bişkin Çetin, Fatma Cebeci.
      
    DOI:  https://doi.org/10.1097/CIN.0000000000001340
  60. Curr Med Imaging. 2025 Jun 05.
    Analysis of Research Hotspots and Development Trends in the Diagnosis of Lung Diseases Using Low-Dose CT Based on Bibliometrics.
    Xi Liu, Xiaoyu Chen, Yang Jiang, Yiming Chen, Dechuan Zhang, Longling Fan.
       BACKGROUND: Lung cancer is one of the main threats to global health, among lung diseases. Low-Dose Computed Tomography (LDCT) provides significant benefits for its screening but also brings new diagnostic challenges that require close attention.
    METHODS: By searching the Web of Science core collection, we selected articles and reviews published in English between 2005 and June 2024 on topics such as "Low-dose", "CT image", and "Lung". These literatures were analyzed by bibliometric method, and CiteSpace software was used to explore the cooperation between countries, the cooperative relationship between authors, highly cited literature, and the distribution of keywords to reveal the research hotspots and trends in this field.
    RESULTS: The number of LDCT research articles show a trend of continuous growth between 2019 and 2022. The United States is at the forefront of research in this field, with a centrality of 0.31; China has also rapidly conducted research with a centrality of 0.26. The authors' co-occurrence map shows that research teams in this field are highly cooperative, and their research questions are closely related. The analysis of highly cited literature and keywords confirmed the significant advantages of LDCT in lung cancer screening, which can help reduce the mortality of lung cancer patients and improve the prognosis. "Lung cancer" and "CT" have always been high-frequency keywords, while "image quality" and "low dose CT" have become new hot keywords, indicating that LDCT using deep learning techniques has become a hot topic in early lung cancer research.
    DISCUSSION: The study revealed that advancements in CT technology have driven in-depth research from application challenges to image processing, with the research trajectory evolving from technical improvements to health risk assessments and subsequently to AI-assisted diagnosis. Currently, the research focus has shifted toward integrating deep learning with LDCT technology to address complex diagnostic challenges. The study also presents global research trends and geographical distributions of LDCT technology, along with the influence of key research institutions and authors. The comprehensive analysis aims to promote the development and application of LDCT technology in pulmonary disease diagnosis and enhance diagnostic accuracy and patient management efficiency.
    CONCLUSION: The future will focus on LDCT reconstruction algorithms to balance image noise and radiation dose. AI-assisted multimodal imaging supports remote diagnosis and personalized health management by providing dynamic analysis, risk assessment, and follow-up recommendations to support early diagnosis.
    Keywords:  CiteSpace.; Low-dose CT; artificial intelligence; bibliometrics; lung cancer screening
    DOI:  https://doi.org/10.2174/0115734056402094250530075121
  61. Health Care Transit. 2025 ;3 100105
    Bibliometric analysis of transition readiness in adolescents with chronic diseases.
    Yao Zhang, Xuewei Chen, Yi Qi, Yiwen Hu, Ziling Xie, Chaoqun Dong.
       Objective: This study aims to explore current hot topics and research trends in transition readiness for adolescents with chronic diseases using a bibliometric methodology.
    Methods: The Web of Science database core collection was searched for literature related to transition readiness in adolescents with chronic diseases published from January 1, 2000, to December 31, 2024. CiteSpace and VOSviewer were adopted to analyze the publication characteristics.
    Results: The results showed that, the number of studies on transition readiness is increasing in a wave-like pattern. The hot topics about the transition readiness of adolescents with chronic diseases can be summarized as follows: adolescents with sickle cell disease, epilepsy, crohn's disease, transplantation and neurogastroenterology-related diseases, the validation of The Self-Management and Transition to Adult Treatment Questionnaire, the crucial role of parents, care coordination, vocational readiness, quality of life, and health literacy. Based on the burst keywords, transition readiness-related influencing factors, comprehensively exploring the transition readiness of adolescents with chronic diseases, identifying specific intervention goals, and systematically constructing intervention programs may be future research trends.
    Conclusions: This study systematically reviews the current state of research on transition readiness for adolescents with chronic diseases and analyzes potential future trends that can provide input into the direction of healthcare transition research.
    Practical implications: By highlighting hot topics and trends in the field, this research contributes to raising awareness among healthcare professionals and researchers of areas in need of further attention, and helps them to identify potential gaps and opportunities in their own clinical practice or research efforts.
    Keywords:  Adolescent; Bibliometrics analysis; Chronic disease; Data visualization; Transition readiness
    DOI:  https://doi.org/10.1016/j.hctj.2025.100105
  62. J Taibah Univ Med Sci. 2025 Jun;20(3): 298-306
    Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis.
    Muthmainah Muthmainah, Nanang Wiyono, Faris K Syah, Adityas Purnianto, Ratih D Yudhani, Brian Wasita.
      Parkinson's disease (PD) is a prevalent neurodegenerative disorder without a definitive cure. Oxidative stress is significantly implicated in its pathogenesis, prompting interest in N-acetylcysteine (NAC), a strong antioxidant and cysteine precursor, as a potential therapeutic agent. We conducted a bibliometric analysis of 421 Scopus articles to assess current trend and future potential of research on the use of NAC in Parkinson's disease. The number of publications related to this topic reached the peaked in 2010 and gradually decreased afterward. We identified 4 main clusters of research theme related to the potential mechanism of NAC effects on Parkinson's disease progression. These include research focusing on NAC effects on oxidative stress, dysfunction of the mitochondria, aberrant protein accumulation and clearance and inflammation. Investigating NAC effect for Parkinson's disease in human is a potential research area.
    Keywords:  Bibliometric analysis; N-acetylcysteine; Network analysis; Parkinson's disease
    DOI:  https://doi.org/10.1016/j.jtumed.2025.05.004
  63. World J Gastroenterol. 2025 May 14. 31(18): 105836
    Plant extracts with antioxidant and hepatoprotective benefits for liver health: A bibliometric analysis of drug delivery systems.
    Gaurav Mittal, Prashanth A, Arkadeep Dhali, Roshan Prasad, Yogesh S, Khulud Mahmood Nurani, Mihnea-Alexandru Găman.
       BACKGROUND: The rising global burden of liver diseases, such as non-alcoholic fatty liver disease and liver fibrosis, has necessitated innovative therapeutic approaches. Plant-based therapies, recognized for their anti-inflammatory and antioxidant properties, have shown promising effects. However, poor bioavailability limits their clinical application.
    AIM: To map global research trends, key contributors, and emerging themes in plant-based therapies combined with advanced drug delivery systems for liver health.
    METHODS: Using the Scopus database, 645 documents were retrieved and analyzed using bibliometric tools Biblioshiny and VOSviewer. Analysis focused on publication trends, geographical contributions, and advancements in drug delivery technologies, including nanoparticles, liposomes, and polymeric micelles. Metrics such as publication growth rate, authorship collaboration, and thematic clustering were assessed.
    RESULTS: The dataset spans 43 years (1981-2024), with an annual growth rate of 11.09% in the number of publications. Research output is dominated by China (33%), followed by the United States (24%) and India (18%). Collaborative studies accounted for 24.34% of publications, with an average of 5.81 co-authors per document. Key innovations include nanoparticle encapsulation of curcumin and silymarin, improving bioavailability by up to 85%. Highly cited studies demonstrated the antioxidant, anti-inflammatory, and anti-fibrotic properties of these compounds. For instance, curcumin nanoparticles showed a 70% improvement in solubility, and silymarin liposomal formulations enhanced therapeutic efficiency by 62%. Thematic analysis revealed a transition from basic clinical observations to molecular and pharmacokinetic research, with a focus on oxidative stress mitigation and hepatoprotection.
    CONCLUSION: This study highlights the growing synergy between plant-based therapies and advanced drug delivery systems, with significant contributions from Asian and Western countries. Future efforts should prioritize clinical trials, standardization of plant extract formulations, and interdisciplinary approaches to maximize therapeutic outcomes. The findings provide a foundation for integrating plant-derived compounds into evidence-based hepatological therapies, addressing critical challenges in bioavailability and safety.
    Keywords:  Bibliometric analysis; Bioavailability; Drug delivery; Hepatoprotection; Liver health; Pharmacokinetics; Plant extracts
    DOI:  https://doi.org/10.3748/wjg.v31.i18.105836
  64. PLoS One. 2025 ;20(6): e0325787
    An exploratory study on the publication stages of early access articles in different bibliographic databases: A case study of IEEE journals.
    Yunu Zhu.
      Currently bibliographic databases have included a large number of Early Access (EA) articles. Taking 47 IEEE journals as examples, this study analyzed and compared the differences in publication stages of EA articles in three typical bibliographic databases, including Web of Science Core Collection, Scopus, and Engineering Village Compendex. Qualitative analysis of data sets that may appear in these three databases and their publication stage modes, and quantitative analysis on the number of records, proportion, and journal distributions of each data set and each publication stage mode were conducted. There were totally 7 sub-data sets and corresponding 26 publication stage modes, with 14 "undifferentiated publication stage modes" and 12 "differentiated publication stage modes". Although the proportion of EA records from each "differentiated publication stage mode" was mostly below 1.0%, the absolute quantity of EA records with differences in the publication stage was noteworthy reaching 2516. Among the 47 journals, 23 journals have 7-8 publication stage modes, 1 journal having 18 modes, and 40 journals have one or more "differentiated publication stage modes". Therefore, in IEEE journals, whether for the same EA article or the same journal, the difference in publication stage between these three databases was pervasive and complex.
    DOI:  https://doi.org/10.1371/journal.pone.0325787
  65. J Therm Biol. 2025 May 31. pii: S0306-4565(25)00116-0. [Epub ahead of print]130 104159
    Thermal manipulation during egg incubation in broiler chickens: A scientometric analysis.
    Marcio Gilberto Zangeronimo, Renata Ribeiro Alvarenga.
      Embryonic thermal manipulation (TM) is a promising strategy to mitigate the adverse effects of heat stress on poultry productivity. The aim of this study was to provide a scientometric analysis of the current literature on embryonic TM in broilers, indicating trends, geographic distribution, influential authors, and multidisciplinary links, aiming to provide a comprehensive overview. A search was carried out in December 2024 on Scopus, PubMed, Scielo, and Web of Science using the keywords ("thermal manipulation" OR "temperature manipulation" OR "temperature control" OR "incubation temperature") AND ("incubation" OR "embryo" OR "fetal development") AND broiler. No date restrictions or filters were applied. Only articles that evaluated the TM of embryonated eggs from broilers were selected. Using a dataset of 195 publications from 1994 to 2024, the data were analyzed with Bibliometrix and VOSviewer tools. A sharp increase in scientific output was observed in the last decade, with 71 % of studies published after 2015. Actual central themes include thermotolerance, heat stress, performance, and hatchability. Emerging themes include gene expression, antioxidant, immune response, and acute heat stress. Nine main research networks were identified, with limited interconnection. The United States, Brazil, and Turkey were identified as the main countries, and São Paulo State University, Jordan University of Science and Technology, and Wageningen University are the main research institutions. This study shows how TM during egg incubation has become important in broilers and how it can help them handle heat stress better. Future research should focus on combining TM with genetic, nutritional, and environmental strategies to make the birds more productive and sustainable.
    Keywords:  Global research trend; Hatchability; Heat stress; Poultry; Science mapping; Thermotolerance
    DOI:  https://doi.org/10.1016/j.jtherbio.2025.104159
  66. Public Health Chall. 2023 Sep;2(3): e110
    The state of global research on poverty after SDG declaration.
    Kehinde Kazeem Kanmodi, Jimoh Amzat, Lawrence Achilles Nnyanzi.
       Background: Poverty is a significant global problem which can hinder the attainment of the United Nations' (UN) Sustainable Development Goals (SDGs). Poverty reduction or elimination requires adequate scientific or research contributions, creating socio-scientific frames that could inform relevant stakeholders in policy planning, implementation and evaluation. This study aims to review the state of global research on poverty (2016 and upwards), since the UN's declaration of SDGs in 2015.
    Methods: This study adopted a bibliometric review design. On 31 May 2022, a systematic SCOPUS-based search was conducted to retrieve all journal papers published on poverty (2016 till 31 May 2022). The bibliometric data of the retrieved papers were analysed using Microsoft Excel and VOSviewer software.
    Result: A total of 15,143 journal papers on poverty were retrieved, of which 91.2% were published in English, whereas slightly more than half (52.9%) were published in the social sciences. Although all regions of the world sourced journal papers on poverty, however, countries from the Global North, particularly the USA and the United Kingdom, dominated other countries in terms of authorship, funding and institutional affiliations. Among Global South countries, China leads in terms of authorship, funding and institutional affiliations. South America and Africa contributed the smallest volume of journal papers on poverty.
    Conclusion: There exist global inequalities in research productivity on poverty. The global poverty problem skews to the Global South, but the scientific contributions flow from the Global North. There is a need to narrow the existing inequality gaps in the research productivity on poverty through North-South synergetic research collaborations.
    Keywords:  SDG; Sustainable Development Goals; United Nations; bibliometric analysis; global development; global health; inequality; poverty; research capacity; review
    DOI:  https://doi.org/10.1002/puh2.110
  67. Regen Ther. 2025 Dec;30 47-62
    Mapping intellectual structures and research hotspots of chronic wound in global perspective.
    Yushu Zhu, Yizhen Lin, Sujie Xie, Mingxuan Yang, Wei Zhang, Minjuan Wu, Yifan Liu, Dayuan Xu, Shuyuan Xian, Xirui Tong, Jie Huang, Luofeng Jiang, Xinya Guo, Minyi Gu, Hengkai Yu, Xinran Ding, Yixu Li, Yiyao Du, Heng He, Jianyu Lu, Runzhi Huang, Shizhao Ji.
       Background: Chronic wounds included but were not limited to diabetes foot ulcers, venous leg ulcers and pressure ulcers. The challenge of difficult healing placed a heavy burden on patients and society. Our objective was to explain the healing process of chronic wounds and the development of treatment technologies in the past few years and to provide relevant, valuable information.
    Methods: Our scientific publications were retrieved from the core collection of the Web of Science (WoSCC) database collection. The bibliometric visualization and analysis were performed by the software Biblioshiny based on R-bibliometrix. VOSviewer software and Citespace software were responsible for the validation of the results.
    Results: A total of 8129 articles related to wound healing in chronic wounds were retrieved. The countries, institutions, and journals with the highest number of publications were the USA, the N8 research partnership, and the Journal of Wound Care, respectively. Armstrong DG and Dumville JC were the most influential authors in this field. The keyword analysis showed two key clusters of keywords, including "dressings" and "management". Trend topics analysis revealed frequent keywords in recent years, including "nanofibers" and "injectable hydrogels".
    Conclusion: Our research was the first to reveal the cellular and molecular mechanisms and key clinical management strategies in the healing process of chronic wounds in the future through metrological and systematic evaluation, which may have important translational value in the future.
    Keywords:  Chronic wounds; Dressings; Healing; Management; Negative pressure wound therapy (NPWT)
    DOI:  https://doi.org/10.1016/j.reth.2025.05.002
  68. Med J Armed Forces India. 2025 Mar-Apr;81(2):81(2): 126-138
    Front-of-package food labeling and noncommunicable disease prevention: A comprehensive bibliometric analysis of three decades.
    Alok Singh, Akanksha Singh, Sudip Bhattacharya.
      Noncommunicable diseases (NCDs) are a major obstacle to global sustainable development, as recognized in the Agenda 2030 framework. Each year, NCDs cause around 41 million deaths, making up 74% of global annual deaths. Alarmingly, 17 million of these deaths occur in people under 70 years old. This growing impact has led healthcare authorities to focus on public health strategies that encourage healthier diets to reduce nutrition-related chronic diseases. In this context, front-of-pack nutrition labels (FoPLs) have gained attention as a tool to help consumers make healthier food choices by providing clear nutritional information. A recent bibliometric analysis using data from the SCOPUS database examined 379 publications on FoPLs and NCDs from 1994 to 2024. It revealed important trends and insights in this research area. Julia C was identified as the most prolific author in the field. U.S.-based institutions have been leading in FoPL research, advancing understanding and initiatives. The journal "Nutrients" emerged as a key platform for publishing research on FoPLs and NCDs. The most cited article in this domain, "Fiber and Prebiotics: Mechanisms and Health Benefits" by Slavin et al. stands out for its influence. The analysis also highlighted the country-specific patterns of FoPLs and their impact on NCD prevention. Furthermore, it showcased the collaborative efforts of institutions like Curtin University, University of Wollongong, Sorbonne Paris Cité, University of New South Wales, and Deakin University in advancing research and addressing the global NCD crisis. This study emphasizes the importance of international cooperation in tackling NCDs through improved food labeling practices.
    Keywords:  Front of package food label; Healthy dietary habits; Non-communicable disease; Nutritional information
    DOI:  https://doi.org/10.1016/j.mjafi.2024.12.003
  69. Public Health Chall. 2023 Dec;2(4): e117
    Setting the agenda for diabetes research in the state of Qatar.
    Amit Mishra, Suresh Babu Kokku, Ioanna Skaroni, Kholoud Ateeq Al Motawaa, Mohammed Al-Thani, Nicholas Wareham, Abdul Badi Abou-Samra, Shahrad Taheri.
       Background: The burden of non-communicable diseases, including diabetes, is high in the Middle East and North Africa (MENA) region. Qatar (a MENA country) has a high prevalence of diabetes (16.7%). Over the past 20 years, Qatar has made significant investment to establish a biomedical research infrastructure. This article documents the processes adopted for the development of a national diabetes research agenda for Qatar.
    Methods: To develop the diabetes research agenda, a three-step process was adopted. First, a bibliometric analysis of diabetes-related research publications was conducted to understand current research and funding patterns. Second, through in-depth interviews and a national consultative workshop, the challenges associated with diabetes research and their potential solutions were documented. Third, an expert team assimilated the recommendations to finalise the diabetes research agenda for the State of Qatar.
    Results: A steadily increasing number of diabetes research publications and collaboration with researchers from 48 different countries was noted. Aetiological research (49%), mainly from cohort studies, dominated research publications. The national diabetes research agenda prioritised five research areas focused on diabetes prevention, early detection, reversal, treatment development and evaluation and system research for improved outcomes. Under each area, a set of research questions were identified to guide the research community to align their research interests with high-priority research in diabetes.
    Conclusion: The national research agenda development process has uncovered some important knowledge gaps and outlined the most impactful areas for diabetes research. Achievement of the objectives of the research agenda requires enhanced collaboration among the research community, sustained research funding and enabling a robust regulatory framework.
    Keywords:  Middle East and North Africa; Qatar; diabetes mellitus; non‐communicable diseases; research agenda
    DOI:  https://doi.org/10.1002/puh2.117
  70. JAMA Netw Open. 2025 Jun 02. 8(6): e2515160
    Citation Contamination by Paper Mill Articles in Systematic Reviews of the Life Sciences.
    Gengyan Tang, Hao Cai.
       Importance: Systematic reviews are the criterion standard for evidence synthesis in the life sciences, yet their reliability and integrity are threatened by citation contamination from fabricated publications produced by paper mills. Despite growing awareness, the extent and implications of this issue remain unclear.
    Objectives: To analyze the prevalence, characteristics, affected subject areas, and citation patterns of retracted paper mill articles cited in systematic reviews.
    Design, Setting, and Participants: This cross-sectional study analyzed systematic reviews published between 2013 and 2024, indexed in Web of Science (WoS). References were matched against the Retraction Watch dataset, and full texts were reviewed to identify retracted paper mill articles incorporated into the evidence synthesis.
    Main Outcomes and Measures: The study assessed (1) contamination prevalence, defined as the proportion of systematic reviews incorporating retracted paper mill articles into the evidence synthesis; (2) geographic distribution of citing authors according to institutional affiliations; (3) citation timing and trends, including the time lag between incorporation and article retraction; (4) affected research areas, categorized by WoS subject classifications; and (5) citation patterns, including highly contaminated reviews (≥3 incorporations of retracted articles).
    Results: Of the total of 200 000 systematic reviews, 299 incorporated at least 1 retracted paper mill article into the evidence synthesis (contamination rate, 0.15%). Among them, 256 (85.6%) included a single retracted article, and 43 (14.4%) included multiple such articles. Of 1802 author affiliations associated with the contaminated reviews, 660 (36.6%) were from institutions in China. Of 385 total citations, 124 (32.2%) occurred after retraction, including 13 occurring more than 500 days after the retraction date. Oncology was the most affected field (48 of 299 [16.1%]). Five reviews each included 5 or more retracted articles, all published in journals under questionable publishers.
    Conclusions and Relevance: In this cross-sectional study of life sciences systematic reviews, contamination remained low but increased over time, posing a risk to research integrity. Continued citation of retracted articles, even after retraction, highlights the need for rigorous screening practices. Correcting contaminated reviews and developing automated detection tools are essential to preserving the credibility of systematic reviews.
    DOI:  https://doi.org/10.1001/jamanetworkopen.2025.15160
  71. J Am Acad Orthop Surg. 2025 Jun 05.
    Gender Representation Among Foot and Ankle Conference Presenters and Research Authors: A 10-year Analysis (2012 to 2022).
    Marguerite A Mullen, Emmanuel Budis, Arianna L Gianakos, Soheil Ashkani-Esfahani, Christopher W DiGiovanni, Daniel Guss.
       BACKGROUND: Today women are more than 50% of medical school matriculants but remain underrepresented in orthopaedic surgery. Moreover, the rate of female orthopaedic subspecialty society membership and representation among meeting speakers is believed to be low. The objective of this study was to assess whether a gap exists in female representation among invited speakers at American Orthopaedic Foot & Ankle Society (AOFAS) national meetings relative to research productivity, as reflected by authorship in Foot and Ankle International (FAI).
    METHODS: Programs for AOFAS national meetings and FAI articles between January 2012 and December 2022 were retrospectively analyzed. Sex was identified through personal acquaintance or online biographies. Presentations and articles were categorized as "technical" or "nontechnical," where technical was defined as relating to preclinical or clinical practice. The chi-square test was used for comparisons (P < 0.05).
    RESULTS: One thousand twenty AOFAS talks and 2,230 FAI articles were analyzed. 11.08% of AOFAS invited speakers, 15.16% of FAI first authors, and 7.40% of FAI senior authors were women. In 2018 and 2019, women were more likely to give "nontechnical" AOFAS presentations (P = 0.003). The average annual trend was +2.00% female AOFAS presenters and +0.31% FAI female first authors per year. FAI female senior authorship had an average annual decrease of -0.37%.
    DISCUSSION: Women represented 15.16% of first authors in FAI between 2012 and 2022 and 11.08% of invited speakers at AOFAS meetings. Meanwhile, the percentage of women in AOFAS increased from 7.5% to 13%. Although female foot and ankle surgeons have been historically underrepresented in the field, they were proportionally represented in 2021 and 2022 among invited national conference presentations and first author research compared with society membership. There remains room to increase representation of deserving groups; however, the proportion of female AOFAS presenters demonstrates a positive trend.
    LEVEL OF EVIDENCE: Level III.
    DOI:  https://doi.org/10.5435/JAAOS-D-24-00126
  72. Int J Environ Health Res. 2025 Jun 10. 1-14
    Nature-based interventions system for the urban population with sub-healthy state: an analysis using the CiteSpace and VOSviewer.
    Bo Jiang, Binxia Xue, Tongyu Li, Claudia Kam Yuk Lai, Anna Maria Pálsdóttir, Msasi Lilian.
      Amid rapid urbanization and rising health challenges, nature-based interventions (NBI) have emerged as a multidisciplinary focus for enhancing well-being and environmental sustainability. This study analyzed 35,418 publications from the Web of Science (1985-2023) using bibliometric tools (CiteSpace, VOSviewer) to map trends in NBI research. The annual number of publications, research institutions, and keywords were systematically analyzed. The conclusions drawn from this analysis are as follows: (1) The annual publication volume in the field of nature-based interventions has been steadily growing, reflecting the rising interest and recognition of its importance within the research community; (2) The research direction is gradually exhibiting diverse characteristics, spanning multiple disciplinary fields; (3) The current research predominantly emphasizes on four dimensions of nature-based interventions: physiological therapy, mental health, rehabilitation effects of physical activity, and the enhancement of quality of life across various population group. However, systematic exploration of the benefits of nature-based interventions for the sub-healthy population remains limited particularly concerning their impact on social health. Therefore, future research should place greater emphasis on examining the interactive relationship between nature-based interventions and the social health of sub-healthy populations, offering valuable references and inspiration for further research.
    Keywords:  Nature-based interventions; bibliometrics analysis; city; sub-healthy population; visualization
    DOI:  https://doi.org/10.1080/09603123.2025.2518165
  73. JB JS Open Access. 2025 Apr-Jun;10(2):pii: e24.00246. [Epub ahead of print]10(2):
    Health Equity Research in Orthopaedic Surgery: A Systematic Review and Needs Assessment.
    Eric Durudogan, Peter C Shen, Jasmin S Vargas, Abdullah Arif, Amin Alayleh, Neeraj M Patel.
       Background: The aim of health equity research was to initially identify inequities and ultimately eliminate them. Little is known about the content, quality, and impact of health equity research in the orthopaedic literature. Therefore, the purpose of this study was to characterize the state of health equity research in orthopaedic surgery, with attention to temporal and specialty trends, research methodology, and intervention development.
    Methods: The Clarivate Web of Science platform was queried for English-language publications from January 1, 2013, to December 31, 2022. Book chapters, meeting abstracts, proceeding papers, retracted publications, and non-English papers were excluded. Articles were filtered and then reviewed individually. Bibliometric data were noted, including publication year, open access, number of citations, and journal impact factor. We also collected information on clinical specialty, study design, community engagement, whether an intervention was designed or tested, and associated funding sources. Descriptive statistics were then calculated.
    Results: The initial search yielded 7,248 total articles, 855 of which were included. The majority (552/855, 64.6%) were published between 2019 and 2022, with 205 (24.0%) in 2022 alone. Arthroplasty was the most represented subspecialty, with 370 articles (43.3%). Seven hundred eighty-four articles (91.7%) were observational or experimental research studies. Of these, 73.1% had a retrospective design. Only one study (0.1%) used qualitative methods. Thirty-six articles (4.2%) focused on interventions. However, only 8 (0.9%) evaluated original interventions, while the majority of the others retrospectively analyzed the impact of the Patient Protection and Affordable Care Act, Medicaid expansion, or bundled payments. Eighteen publications (2.1%) were directly supported by National Institutes of Health funding.
    Conclusion: There was a sharp increase in the number of orthopaedic publications on disparities, especially since 2019. Most are retrospective and identify or describe a disparity rather than investigate an intervention. There was a near-complete lack of qualitative methodology, community engagement, or federal funding. More institutional and financial support for this work is critical, as is the adaptation of new methodologies and community involvement.
    DOI:  https://doi.org/10.2106/JBJS.OA.24.00246
  74. Turk Arch Otorhinolaryngol. 2025 Jun 10.
    Compliance of ORL-HNS Journals in Türkiye with the Principles of Transparency.
    Esra Çelik, Sibel Kıran, Cem Uzun.
       Objective: Principles of transparency and best practice in scholarly publishing is one of the important standards for the functioning and publishing quality of peer-reviewed scientific journals. The aim of this study is to evaluate Turkish otorhinolaryngology, head and neck surgery (ORL-HNS) journals according to these principles and to point out the areas that need improvement.
    Methods: This descriptive study is based on the evaluation of website contents of eight Turkish ORL-HNS journals according to the 16 principles of transparency criteria. The number of scientific papers published in 2020 and 2021 were retrieved from the respective websites of the journals. The impact factors were calculated by analyzing the citations in 2022 via Google Scholar. The probable relationship between impact factor and compliance with transparency principles was investigated. Impact factor and transparency principles were studied to draw attention to the international standards which can contribute to journals for international scholarly publishing.
    Results: The journals highly comply with website publishing, ethics, access, and ownership criteria; however, most of them do not comply with advisory council, advertising, other income, and business practices criteria. While the first three journals with the highest impact factors comply with 12 to 14 of the 16 criteria, the last three comply with five to 12.
    Conclusion: The journals with high transparency criteria scores and high impact factors suggest that these criteria are important in terms of the reliability and validity of the information, and citation. Moreover, the websites of Turkish scientific ORL-HNS journals were seen to need improvement according to the transparency criteria, especially regarding financial issues such as business, financial status, and advertising.
    Keywords:  Otorhinolaryngology; best practice; journal article; journal impact factor; peer review; scholarly publishing
    DOI:  https://doi.org/10.4274/tao.tao.2025.2024-5-4
  75. Reumatologia. 2025 ;63(2): 68-80
    Three decades of collaboration in rheumatology: a comprehensive co-authorship network analysis (1994-2023).
    Naruaki Ogasawara.
       Introduction: This study investigated the evolution of collaborative research in rheumatology over 3 decades (1994-2023), utilizing co-authorship network analysis to uncover key contributors, structural trends, and global collaboration patterns. The analysis aimed to provide insights into the dynamics of research cooperation and the factors influencing its development.
    Material and methods: A total of 31,231 publications on rheumatology, indexed in the Web of Science (WoS) Core Collection, were analyzed. The co-authorship network was constructed using Python (Version 3.10.5) in the PyCharm environment (Version 2022.1.3). Macro-level metrics, including network density, clustering coefficient, components, and average path length, were evaluated alongside micro-level indicators such as degree centrality, closeness centrality, and betweenness centrality to characterize the network's structure and dynamics. Additionally, temporal trends were examined to assess changes in collaboration patterns over time.
    Results: The analysis revealed an expansion in publication volume and collaboration over the 3 decades, with persistent fragmentation evidenced by low network density (below 0.0005) and numerous disconnected components. The number of active researchers and institutions participating in collaborations increased significantly, contributing to enhanced regional cooperation. Key researchers, including Nicolino Ruperto, Josef S. Smolen, and Yoshiya Tanaka, emerged as central figures, consistently facilitating knowledge exchange and collaboration. Localized, tight-knit collaboration patterns, indicated by high clustering coefficients, persisted despite limited global integration. These findings suggest that while rheumatology research networks are becoming more inclusive, significant disparities in connectivity across regions remain.
    Conclusions: This comprehensive analysis highlights the dual trends of growth and fragmentation in rheumatology research collaboration. While local collaborations thrive, broader integration remains a challenge, underscoring the need for initiatives fostering global connectivity in the research community. Enhancing international collaboration and reducing resource gaps between regions could accelerate advancements in rheumatology research, benefiting both the scientific community and patients worldwide.
    Keywords:  co-authorship network analysis; network analysis; rheumatoid arthritis
    DOI:  https://doi.org/10.5114/reum/200529
  76. World J Diabetes. 2025 May 15. 16(5): 91200
    Scientometric analysis and historical review of diabetic encephalopathy research: Trends and hotspots (2004-2023).
    Xian-Wen Ye, Hai-Xia Zhang, Qian Li, Chun-Shuai Li, Chong-Jun Zhao, Liang-Jing Xia, Hong-Min Ren, Xu-Xing Wang, Chao Yang, Yu-Jie Wang, Shui-Lan Jiang, Xin-Fang Xu, Xiang-Ri Li.
       BACKGROUND: Diabetic encephalopathy (DE) is a common and serious complication of diabetes that can cause death in many patients and significantly affects the lives of individuals and society. Multiple studies investigating the pathogenesis of DE have been reported. However, few studies have focused on scientometric analysis of DE.
    AIM: To analyze literature on DE using scientometrics to provide a comprehensive picture of research directions and progress in this field.
    METHODS: We reviewed studies on DE or cognitive impairment published between 2004 and 2023. The latter were used to identify the most frequent keywords in the keyword analysis and explore the hotspots and trends of DE.
    RESULTS: Scientometric analysis revealed 1308 research papers on DE, a number that increased annually over the past 20 years, and that the primary topics explored were domain distribution, knowledge structure, evolution, and emergence of research topics related to DE. The inducing factors, comorbidities, pathogenesis, treatment, and animal models of DE help clarify its occurrence, development, and treatment. An increasing number of studies on DE may be a result of the recent increase in patients with diabetes, unhealthy lifestyles, and unhealthy eating habits, which have aggravated the incidence of this disease.
    CONCLUSION: We identified the main inducing factors and comorbidities of DE, though other complex factors undoubtedly increase social and economic burdens. These findings provide vital references for future studies.
    Keywords:  Cognitive impairment; Diabetic encephalopathy; Research hotspots; Scientometric analysis; Type 2 diabetes mellitus
    DOI:  https://doi.org/10.4239/wjd.v16.i5.91200
  77. Ageing Res Rev. 2025 Jun 09. pii: S1568-1637(25)00145-X. [Epub ahead of print] 102799
    Trends and Mechanisms of Alzheimer's Disease and Hearing Impairment: A 20-Year Perspective.
    Fen-Fen Li, Jian-Peng Wang, Wen-Jie Zhang, Pin-Ting Zhou, Min Fan, Ning-Ning Cai, Yi-Fan Cai, Ke Han, Yi-Pin Yang, Zi-Yue Fu, Si-Yue Yin, Bing-Yu Liang, Yan-Xun Han, Ye-Hai Liu, Bu-Sheng Tong, Ming-Xu Li, Yu-Chen Liu.
      Alzheimer's disease (AD) and hearing loss (HL) are major age-related public health challenges with emerging evidence suggesting their interconnection. This study aimed to investigate global research trends, shared molecular mechanisms, and clinical implications of AD and HL. A total of 349 articles published between 2004 and 2024 were retrieved from the Web of Science Core Collection and analyzed using VOSviewer and CiteSpace. GeneCards and STRING databases were used to explore molecular targets and pathways. Results showed steady growth in publication volume, with the United States and China as leading contributors. Major keywords included "age-related hearing loss", "cognitive impairment", and "amyloid plaques", and "prevention" represent current and forward-looking future research trends and target themes in the field. Key authors and institutions included Doris-Eva Bamiou, University College London, and the University of California system. Molecular analysis identified 2,747 genes potentially shared between AD and HL, involved in apoptosis, oxidative stress, inflammation, and metabolic dysregulation. Among them, SLC26A4, CDH23, MYO3A, TMC1, and MYO15A were highlighted as representative targets related to auditory and neurodegenerative processes. The study further distinguished between central and peripheral HL: central HL is closely linked to neuroinflammation and synaptic degeneration, while peripheral HL may contribute to cognitive decline through sensory deprivation. These findings support early auditory screening and tailored intervention strategies, and provide a foundation for multi-target approaches in managing cognitive decline, emphasizing the importance of integrating auditory assessment into precision medicine frameworks for aging populations.
    Keywords:  Alzheimer's Disease; Bibliometric Analysis; CiteSpace; Hearing Loss; Mechanisms; VOSviewer
    DOI:  https://doi.org/10.1016/j.arr.2025.102799
  78. Acta Psychol (Amst). 2025 Jun 06. pii: S0001-6918(25)00451-2. [Epub ahead of print]257 105138
    Looking to the past for mapping the future: A bibliometric review of extant creativity research in second language education.
    Huimin Li, Hanwei Wu.
      Research on creativity in second (L2) or foreign language (FL) education has been ongoing for over a decade. However, to our best knowledge, no comprehensive review of the relevant literature has been conducted to date. To address this gap, we perform a bibliometric review using CiteSpace to analyze high-quality studies drawn from the WoS database. This review aims to identify general tendency, key themes, research frontiers, major contributors, and future directions in creativity research within L2 education, thus offering the stakeholders visualized and holistic insights. The results include: (1) Creativity research in L2 education is an emerging field that has seen rapid growth since 2020; (2) Three key themes have been explored in the literature: individual differences, L2 performance, and teaching for creativity; (3) Three main research frontiers have emerged over time: children, personality, and positive psychology; (4) There is a noticeable lack of collaboration both among authors and institutions, with much of the research being concentrated in a few institutions, primarily in China. We also discuss the findings and provide suggestions for future research.
    Keywords:  Bibliometric review; EFL creativity; L2 creativity; L2 education; Language creativity
    DOI:  https://doi.org/10.1016/j.actpsy.2025.105138
  79. J Educ Perioper Med. 2025 Apr-Jun;27(2):27(2): E746
    Does Leave of Absence Affect Publication Productivity for Physician Trainees During Anesthesiology Residency?
    Emily E Sharpe, Monica W Harbell, Ingrid L Hirte, Claire Yee, Emily Reynolds, Madeline Whitney, Molly B Kraus, Sher-Lu Pai.
       Background: Residency occurs for most physicians during the childbearing years. As residents face demanding work schedules, the training experiences may be further stressed by parenthood. There is a perception that residents who take parental leave are less academically productive.
    Methods: We obtained the names of anesthesia residents from Mayo Clinic graduating classes of 2016 to 2021. Google Scholar, EMBASE, and PubMed were used to search for publications by the names of residents. Gender and leave of absence data for each resident during residency were identified. A set of logistic regressions was used to examine leave from work related to the residents' publication outcomes.
    Results: Of the 149 residents included in the study, 49 (32.9%) took parental and 19 (12.75%) took other types of extended leave (≥ 5 days). Those who took parental leave did not differ in likelihood of being published compared with those who took other types of extended leave (P = .066) or no leave (P = .447). No relationship was found between taking parental leave with total number of publications, first author publications, second author publications, or original research publication after controlling for gender, graduation year, or total number of days of leave.
    Conclusions: Taking parental leave did not adversely affect scholarly output among anesthesiology residents at a single multi-site institution.
    Keywords:  Anesthesiology; internship and residency; parental leave; perception; personnel staffing and scheduling; publishing
    DOI:  https://doi.org/10.46374/VolXXVII_Issue2_Pai
  80. Res Social Adm Pharm. 2025 Jun 06. pii: S1551-7411(25)00270-0. [Epub ahead of print]
    Uncovering gaps and opportunities in pharmacist-led medication Reviews: Advancing medication safety and health outcomes for older adults.
    Ammar Abdulrahman Jairoun.
       BACKGROUND: Home Medicines Reviews (HMRs) aim to optimize medication management for older adults receiving in-home care. However, their effectiveness remains constrained by various practical, regulatory, and knowledge challenges, and their long-term impact on health outcomes remains unclear.
    OBJECTIVE: This commentary critically examines these challenges and proposes strategies to enhance HMR implementation. To support this evaluation, a bibliometric analysis was performed using co-occurrence network mapping of keywords from research articles related to HMRs. This approach provided insights into keyword associations, research trends, and developing themes over time.
    DISCUSSION: Findings from the bibliometric analysis indicate that earlier research primarily focused on medication safety and polypharmacy, whereas recent studies have shifted towards patient-centered outcomes, including frailty, quality of life, and deprescription. However, gaps remain in areas such as integrating follow-up procedures, fostering interdisciplinary collaboration, and leveraging technological advancements like electronic health records and telemedicine. Additionally, inconsistent implementation of HMR recommendations, regulatory barriers, and underutilization of pharmacists in elderly care services were identified as key limitations.
    CONCLUSION: maximizing the impact of HMRs on medication safety and quality of life for older adults requires addressing these gaps through proactive policy reforms, expanded pharmacist roles, and digital health solutions. The bibliometric findings highlight the need for a more structured, evidence-based approach to improve the effectiveness and implementation of HMRs.
    Keywords:  Health outcomes; Home medicines review; Medication adherence; Medication review; Older adults; Pharmacist-led review
    DOI:  https://doi.org/10.1016/j.sapharm.2025.06.003
  81. Stem Cell Res Ther. 2025 Jun 07. 16(1): 288
    Bridging the gap: clinical translation of adipose-derived stem cells - a scoping review of clinical trials.
    Hankun Su, Hoksan Chau, Qilin Li, Fen Xiao, Yuanyuan Sun, Jingjing Chen, Yayi He, Jinyao Ning, Qin Hu, Yujie Xiao, Caiwen Li, Bixia Huang, Jing Zhao, Yanping Li, Hui Li.
       BACKGROUND: Adipose-derived stem cells (ADSCs) have emerged as a promising therapeutic tool in regenerative medicine due to their multipotency, immunomodulatory properties, and ease of procurement. Despite extensive preclinical research, the clinical translation of ADSCs remains fragmented, with challenges in standardization, reproducibility, and evidence synthesis.
    OBJECTIVE: This scoping review, complemented by bibliometric analysis, aims to map the landscape of randomized controlled trials (RCTs) evaluating ADSC therapies, identify gaps between basic research and clinical translation, and highlight emerging trends in the field.
    METHODS: A systematic search of Web of Science, PubMed, Embase, ClinicalTrials.gov, EudraCT, and ChiCTR database (2009-2025) identified 82 RCTs. Bibliometric analysis of preclinical studies was conducted using VoSviewer to visualize keyword clusters and temporal trends. Data on trial characteristics, endpoints, and translational challenges were extracted and synthesized.
    RESULTS: The 82 included RCTs spanned 17 medical specialties, with orthopedics (26.8%), dermatology (14.6%), and neurology (9.7%) being the most studied. Spain (21.95%) and China (18.29%) and the USA (15.85%) led trial numbers, but 97% were single-country studies with a median sample size of 40. Primary endpoints trends from safety to efficacy. Bibliometric analysis revealed three clusters: stem cell sources and basic biology, orthopedic applications, and tissue regeneration mechanisms. Key gaps included protocol heterogeneity (e.g., isolation methods, cryopreservation variability), regulatory fragmentation, limited long-term follow-up, and inconsistent clinical outcomes, particularly in neurology. Emerging trends highlighted the therapeutic potential of stromal vascular fraction (SVF) and ADSC-derived exosomes.
    CONCLUSIONS: While ADSCs demonstrate significant therapeutic potential, clinical translation is hindered by standardization deficits and mechanistic knowledge gaps. Future research should prioritize international collaboration, large-scale trials, and mechanistic studies to optimize ADSC therapies. Innovations in SVF and exosome-based treatments represent promising avenues for advancing regenerative medicine.
    TRIAL REGISTRY: This scoping review was preregistered at OSF platform: https://doi.org/10.17605/OSF.IO/YKHW3 .
    Keywords:  Adipose-derived stem cells; Bibliometric analysis; Randomized controlled trials; Regenerative medicine; Scoping review
    DOI:  https://doi.org/10.1186/s13287-025-04405-3
  82. Small Methods. 2025 Jun 08. e2500283
    Rapid Detection of Illicit Drugs: An Analysis of Research Progress and Prospects.
    Tong Dou, Wenzhen Yang, Ziyun Wang, Junzheng Zhang, Chunying Yuan, Jingyi Wang, Zhizhen Xu, Meng Zhang, Dongsheng Wang.
      Rapid detection of illicit drugs has garnered significant attention for its role in preventing and controlling drug abuse, supporting treatment management in healthcare systems, and environmental monitoring. Although various reviews have explored specific methods, samples, or analytes in rapid illicit drug detection, a comprehensive analysis summarizing overall trends in this field remains absent. To support the development and broader application of rapid drug detection technologies, a bibliometric analysis of relevant literature from 2001 to 2023 is conducted, presenting a general bibliometric distribution of studies by year, country, institution, author, journal, and research focus. A more in-depth overview of recent advances in the three major rapid detection methods for illicit drugs, chromatography&mass spectrometry, electrochemical sensing and optical sensing techniques, is provided. The test mechanism, performance, applicable sample types, and pretreatment methods for each technique are systematically summarized. The integrated applications of each technique with machine learning are also addressed. Finally, the challenges and prospects for further development of rapid detection are discussed.
    Keywords:  bibliometric analysis; hotspot evolution; illicit drugs; rapid detection; sample pretreatment
    DOI:  https://doi.org/10.1002/smtd.202500283
  83. Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 09.
    Biographical analysis of 32 pharmacologists persecuted under the Nazi regime: scientific careers between persecution, emigration, and new beginnings.
    Mirja Mispagel, Roland Seifert.
      Founded in 1873, Naunyn-Schmiedeberg's Archives of Pharmacology is the oldest pharmacological journal, and several historical studies have already been published on the occasion of its 150th anniversary. The present study analyzes the influence of the persecution and expulsion of Jewish and dissident German pharmacologists during the Nazi era (1933-1945) on the development of their scientific careers. The analysis is based on the book "Verfolgte deutschsprachige Pharmakologen 1933-1945" (engl. "Persecuted German-speaking pharmacologists 1933-1945") by Ullrich Trendelenburg and Konrad Löffelholz (2008), which contains short biographies of 71 persecuted pharmacologists. For this study, 32 of these scientists were selected and their professional development was analyzed in detail. The results show considerable differences in professional establishment after emigration. Young scientists in the early stages of their careers were usually able to successfully establish themselves in their receiving countries and often reached high academic positions, such as professorships or institute directorships. In many cases, established mid-career scientists were also able to continue and develop their careers abroad. On the other hand, senior pharmacologists who had held professorships or directorships before emigrating often found it difficult to obtain comparable positions abroad. Many had to settle for less senior positions. Tragically, two of the pharmacologists analyzed here were murdered in concentration camps. In addition, the biographies and publications of ten pharmacologists-Wilhelm Siegmund Feldberg, Alfred Fröhlich, Hans Kosterlitz, Otto Krayer, Otto Loewi, Hans Molitor, Ernst Peter Pick, Otto Riesser, Klaus Robert Walter Unna, and Marthe Louise Vogt-are analyzed in detail in this study. Their publications in Naunyn-Schmiedeberg's Archives of Pharmacology, the Journal of Pharmacology and Experimental Therapeutics, and the British Journal of Pharmacology are analyzed in relation to their individual fates and careers. Although there are considerable individual differences, these ten scientists were generally able to successfully establish themselves in their new academic environment despite persecution and emigration. This was mainly due to their exceptional academic commitment, their high level of resilience, and the support they received from international networks and funding organizations. By combining bibliometric and biographical analysis, this study reveals the human and scientific cost of political oppression-and emphasizes the ongoing relevance of protecting academic freedom and diversity in science.
    Keywords:   British Journal of Pharmacology ; Journal of Pharmacology and Experimental Therapeutics ; Naunyn–Schmiedeberg’s Archives of Pharmacology ; Biographies; National socialism; Persecuted pharmacologists; Publication activity; Third Reich
    DOI:  https://doi.org/10.1007/s00210-025-04231-7
  84. J Safety Res. 2025 Jul;pii: S0022-4375(25)00020-9. [Epub ahead of print]93 79-89
    A scientometric analysis of three decades of research on workplace psychosocial hazards: Implications for policy and practice.
    Subas P Dhakal, Muhammad N Mahmood.
       INTRODUCTION: The Workplace Psychosocial Hazards (WPH) agenda has gained policy currency in the context of the United Nations' 17 Sustainable Development Goals (SDGs). For instance, SDG#8 explicitly aims to protect labor rights and promote safe and secure working environments for all workers under the umbrella term of decent work. More importantly, WPH has become a significant priority of workplace health and safety management (WHSM) practices because of the high cost associated with workers' well-being and reduced productivity and performance. Nevertheless, a comprehensive analysis of WPH-related literature remains scant.
    METHOD: This article responds to this gap and analyses scholarly research outputs between 1993 and 2022 available in the Scopus database (n = 521) with two specific objectives: (a) to identify key research trends, key focus areas, collaboration networks, and prominent research institutions/countries and (b) generate insights into informing workplace safety and health management (WSHM) practices and future research.
    RESULTS: The analysis revealed that the research topics with the most emphasis were occupational health, mental health and stress. In contrast, topics such as policy assessment, sustainable development, and shift work received the least attention.
    PRACTICAL APPLICATIONS: Given that the scientometrics analysis has the potential to inform the WPH agenda, this article contributes to the discussions on three thematic implications of the analysis in the context of future research directions: (a) policy initiatives, (b) WHSM practices, and (c) research partnerships.
    Keywords:  Evidence-based management; Gephi; Sustainable development; VOSviewer; Workplace health and safety management
    DOI:  https://doi.org/10.1016/j.jsr.2025.02.011
  85. J Pharm Bioallied Sci. 2025 May;17(Suppl 1): S66-S69
    The Art of Quality Health Science Article Writing for Peer-Reviewed Professional Journals: A Review Article.
    Shreya Buvariya, M C Prasant, Arun G Krishna, Akshay Kumar Mavani, Gosai Mayurgiri Vilasgiri, Gopal Singh Thakur, Rahul Tiwari.
      Navigating the intricacies of writing a peer-reviewed medical article demands meticulous adherence to guidelines and an acute understanding of the publication process. This discourse provides a comprehensive overview, emphasizing the crucial components requisite for a successful publication. Delving into the structuring nuances, it delineates the essential elements spanning from title formulation to conclusion drafting. The significance of adherence to journal-specific guidelines, avoidance of plagiarism, and recognition of impact factors are underscored. Furthermore, it elucidates the distinct sections of a medical article, including Introduction, Materials and Methods, Results, and Discussion, elucidating their roles in conveying research findings effectively. Notably, it expounds on the diverse types of health science articles, ranging from original research to systematic reviews, delineating their unique characteristics. Moreover, insights into indexing criteria and impact assessment metrics, such as h-index and journal impact factor, are provided, elucidating their implications for publication success. Finally, common reasons for article rejection and strategies for enhancing publication prospects are discussed, underscoring the evolving landscape of evidence-based medical writing.
    Keywords:  Article writing; journal publications; medical publications; peer-reviewed journal
    DOI:  https://doi.org/10.4103/jpbs.jpbs_651_24
  86. J Surg Res. 2025 Jun 09. pii: S0022-4804(25)00276-8. [Epub ahead of print]312 7-14
    R01 Funding for Surgeons; What Are the Key Factors for Success?
    Shadin Ghabra, Lindsay A Demblowski, Carolina Larrain, Hyoyoung Choo-Wosoba, Martha A Zeiger.
       INTRODUCTION: Recent studies report a decrease in R01 grants awarded to surgeon-scientists compared to nonsurgeons. We determined the key factors associated with a successful R01 grant application for surgeon-scientists.
    METHODS: Surgeon-scientist principal new investigators (PIs) who applied for an R01 grant during fiscal years (FY) 2018-2023 were identified using an National Institutes of Health internal data platform. Individual and multivariable analyses were performed for gender, degree (medical degree with or without PhD), previous research training grants (F32 and T32), same faculty and clinical training institution, previous mentored funding (K08, K23, and K99), and Hirsch index for awarded and nonawarded PIs. Preliminary analyses were conducted to explore associations between the R01 award and each variable followed by a multiple logistic regression analysis.
    RESULTS: Of 310 (35.1%) R01-awarded surgeon PIs, there was no statistical difference in the proportion of awarded men (n = 203, 34.5%) versus women (n = 107, 36.5%) PIs (P = 0.55). The results indicated a strong likelihood of success for PIs with a PhD degree (univariable P = 0.007; odds ratio (OR) = 1.39, P = 0.042 by the logistic model), for those who were previously on an F32 or T32 training grant (P = 0.008; OR = 1.51, P = 0.025), and were previously awarded a mentored-career grant (K08, K23, or K99) (P < 0.0001; OR = 2.72, P < 0.0001). In contrast, remaining at the same organization as their surgical training (P = 0.069; OR = 1.27, P = 0.109), and an h-index ≥40 (P = 0.183; OR = 1.34, P = 0.184) were not indicators of success.
    CONCLUSIONS: Variables identified for successfully transitioning to independent R01 as first investigator surgeon scientist funding include holding a PhD degree, a previous research training grant, and a previous mentored career award.
    Keywords:  NIH funding; NIH grant; New investigator; R01 grant; Surgeon-scientist; Surgical research
    DOI:  https://doi.org/10.1016/j.jss.2025.04.050
  87. Sci Data. 2025 Jun 09. 12(1): 964
    CS-KG 2.0: A Large-scale Knowledge Graph of Computer Science.
    Danilo Dessí, Francesco Osborne, Davide Buscaldi, Diego Reforgiato Recupero, Enrico Motta.
      The rapid evolution of AI and the increased accessibility of scientific articles through open access marks a pivotal moment in research. AI-driven tools are reshaping how scientists explore, interpret, and contribute to the body of scientific knowledge, offering unprecedented opportunities. Nonetheless, a significant challenge remains: dealing with the overwhelming number of papers published every year. A promising solution is the use of knowledge graphs, which provide structured, interconnected, and formalized frameworks that improve the capabilities of AI systems to integrate information from the literature. This paper presents the last version of the Computer Science Knowledge Graph (CS-KG 2.0), an extensive knowledge base generated from 15 million research papers. CS-KG 2.0 describes 25 million entities linked by 67 million relationships, offering a nuanced representation of the scientific knowledge within the field of computer science. This innovative resource facilitates new research opportunities in key areas such as analysis and forecasting of research trends, hypothesis generation, smart literature search, automatic production of literature review, and scientific question-answering.
    DOI:  https://doi.org/10.1038/s41597-025-05200-8
  88. Med Teach. 2025 Jun 12. 1-10
    Peer-to-peer mentorship emerges from mandatory research coursework: A social network case study.
    Setthanan Jarukasemkit, Seksan Yoadsanit, Chawisa Teansue, Peerapass Sukkrasanti, Phanuwich Kaewkamjornchai, Borwornsom Leerapan.
       PURPOSE: Research training thrives when pairing coursework with peer-to-peer mentorship. To understand how emerging collaborations promote research productivity of medical students, this study investigates the development of peer-to-peer advice-seeking behaviors and identify social mechanism that fosters collaborations.
    METHOD: Cross-sectional surveys on advice-seeking behaviors were collected from 95 medical students awarded research presentation or publication grants from 2016 to 2023. Interrupted time series analysis (ITS) assessed the impact of research coursework, and SNA visualized the advice-seeking patterns and community structure. Path analysis and subgroup analysis identified influential factors that led to grant awarding.
    RESULTS: ITS showed an increase in grant awarding after the coursework implementation. SNA revealed a shift toward decentralized peer-to-peer advice-seeking behaviors, as group formation mediated grant awarding by 20.41%. Students preferentially seek advice from those at similar educational stages, regardless of gender and research interest. Subgroup analysis revealed advice-seeking differences across genders, educational stages, cohorts, and publication statuses.
    CONCLUSIONS: The network perspective highlights that group formation is a mediator of research productivity. Educators should consider a growing trend towards peer-to-peer mentorship and the influence of institutional policies on student behaviors. Understanding advice-seeking patterns can inform effective strategies to support and enhance undergraduate research engagement.
    Keywords:  advice seeking; peer-to-peer mentorship; research coursework; social network analysis; undergraduate research
    DOI:  https://doi.org/10.1080/0142159X.2025.2513425
  89. Am J Sports Med. 2025 Jun 07. 3635465251333088
    The Utilization of Patient-Reported Outcome Measures in Assessing the Treatment of Osteochondral Lesions of the Ankle Versus the Knee.
    Darius Luke Lameire, Caroline Cristofaro, Jong Min Lee, Kathrine Bhargava, Shgufta Docter, David Wasserstein, Sam Si-Hyeong Park.
       BACKGROUND: When assessing the outcomes of ankle and knee osteochondral lesions (OCLs), there are numerous patient-reported outcome measures (PROMs) that are used; however, not all are validated.
    PURPOSE: To compare the utilization of PROMs in assessing the treatment of ankle OCLs versus knee OCLs.
    STUDY DESIGN: Systematic review; Level of evidence, 4.
    METHODS: A systematic search of Embase, MEDLINE, and CINAHL was conducted to identify all observational or experimental studies from January 1, 2014 to December 31, 2023 that used PROMs to assess the treatment of ankle or knee OCLs. The frequency of the use of specific validated PROMs between the ankle OCL and knee OCL literature was compared using an independent t-test. Correlation coefficients were calculated to assess differences based on journal impact factor (divided into quartiles), publication year, or level of evidence.
    RESULTS: A total of 233 eligible ankle OCL studies and 211 knee OCL studies were identified. Validated clinical outcome measures were used in 41.2% of ankle OCL studies compared with 87.7% of knee OCL studies (P < .001). There were a total of 44 outcome measures used in ankle OCL studies, with the majority of studies (67.8%) utilizing the AOFAS (American Orthopaedic Foot and Ankle Society) score. There were no correlations between the use of validated outcome measures in the ankle OCL studies and journal impact factor (P = .78), publication year (P = .16), or level of evidence (P = .45). Similarly, there were no correlations for the knee OCL studies based on journal impact factor (P = .60), publication year (P = .25), or level of evidence (P = .55).
    CONCLUSION: Validated clinical outcome measures were more frequently utilized in knee OCL studies compared with ankle OCL studies. The low frequency of validated outcome measures used within the ankle literature may limit how well treatment effectiveness in the management of ankle OCLs is evaluated.
    Keywords:  PROMs; ankle; knee; osteochondral; outcomes; valid
    DOI:  https://doi.org/10.1177/03635465251333088
  90. Forensic Sci Int. 2025 May 30. pii: S0379-0738(25)00151-3. [Epub ahead of print]373 112513
    A scientometric review of explosives research: Challenges and opportunities.
    Amy Bruce, Lotte E Timmerman, Nana A Fiakpui, Lauren Lessey, Matthew S Beardah, Niamh Nic Daéid, Hervé Ménard.
      It is well documented that the amount of scientific literature is increasing annually, leading to increased effort being required to understand the breadth and depth of a field of interest. To address this challenge, a scientometric approach focussing on keyword analysis was used to evaluate explosives evidence in forensic science and identify trends, gaps, and opportunities. Analysis was carried out by examining the references contained in the triennial INTERPOL International Forensic Science Managers Symposium (IFSMS) reports (4665 references) and through a search for "explosive" in the Scopus citation database (70,699 references) to map the research landscape. This study focusses specifically on keyword representation and aims to identify opportunities to improve the searchability and accessibility of future published research. It was found that while analytical techniques are well represented and easily identified in the literature, other research areas such as the recovery of explosive traces are not. Military explosives, especially TNT, are the most referenced explosive compounds within the literature, however, it was challenging to identify literature on specific explosives, as compounds are often not included in searchable fields. To address these limitations, the use of standardised supplementary material is proposed to improve future searchability and discoverability. It is recommended that the explosives community come together to agree the most suitable strategy. This would enable researchers and practitioners to conduct focussed literature searching and develop a deep understanding across the field of explosives research.
    Keywords:  Explosives; Forensic science; Lexicon; Scientometric; Standardisation
    DOI:  https://doi.org/10.1016/j.forsciint.2025.112513
  91. ACS Synth Biol. 2025 Jun 13.
    Revolutionizing DNAzyme Biosensors: Pioneering Strategies, Advanced Immobilization, Versatile Applications, and Future Frontiers.
    Adwaita Sr Nair, Arup Samanta, Saugata Hazra.
      The hybridization chain reaction (HCR) is an amplification method recognized for detecting analytes present in trace quantities owing to its high specificity, sensitivity, and straightforward approach. Simultaneously, G-quadruplex DNAzymes augment HCR-based biosensors, serving as transducers due to their elevated catalytic activity and nonenzymatic methodology. The current review aims to provide readers with a critical overview of significant aspects of biosensors that utilize HCR for analyte detection amplification and G-quadruplex as transducers, focusing on the latest activities of global researchers. A bibliometric analysis was conducted to identify key research topics in HCR and G-quadruplex-based sensors. Further, the review aims to elucidate the advantages and disadvantages of each strategy employed for detection using this sort of sensor. Specific sections have been included to critically evaluate the potential of these biosensors across many scientific domains. In conclusion, the limitations of the existing sensor that restrict its applicability in real-time scenarios have been identified for subsequent enhancement. Plausible strategies that could enhance these sensors and emerging scientific fields that could benefit from HCR and G-quadruplex DNAzyme-based sensors have been elucidated.
    Keywords:  DNAzyme; G-quadruplex; biosensors; detection; hybridization chain reaction
    DOI:  https://doi.org/10.1021/acssynbio.5c00074
  92. JSES Int. 2025 May;9(3): 844-851
    The impact of social media for shoulder surgeons: a prevalence and correlation study with online and academic presence.
    Sameer R Khawaja, Krishna N Chopra, Musab Gulzar, Nicole L Greene, Anna Gorsky, Zaamin B Hussain, Michael B Gottschalk, Adrian L Huang, Christopher S Klifto, Eric R Wagner.
       Background: Social media use has grown exponentially in the past decade and has become a powerful tool for physicians. A strong online presence can play a vital role for surgeons in patient recruitment and education and in promoting new literature. This study examines the influence of social media use on patient-reported online ratings and academic productivity among shoulder and elbow and sports medicine fellowship-trained orthopedic shoulder surgeons.
    Methods: The American Shoulder and Elbow Surgeons directory was queried for all active members who completed either a shoulder and elbow or sports medicine fellowship in the United States. Each name was searched on Twitter/X, Instagram, LinkedIn, ResearchGate, Facebook, TikTok, and YouTube for professional accounts, and the number of followers was recorded for each. The presence of a practice group or personal website was also recorded. Average ratings, number of reviews, and number of comments were collected from Healthgrades, Google Reviews, and Vitals. H-index was searched on Scopus. A summated social media presence score was calculated to identify the top 15% of social media users in each cohort.
    Results: 134 shoulder and elbow and 97 sports medicine fellowship-trained orthopedic shoulder surgeons were included in this review. The top 15% of social media users consisted of 35 shoulder surgeons: 16 with a shoulder and elbow fellowship and 19 with a sports medicine fellowship. The top 15% of users completed fewer years of practice on average since fellowship compared to the bottom 85%. On Healthgrades, the top 15% possessed higher mean ratings, number of ratings, and number of comments compared to the rest of the cohort. Active Instagram users had higher mean ratings on Google Reviews compared to those without an active profile. Across all social media platforms, those with profiles were found to have either similar or higher patient engagement on Healthgrades, Google Reviews, and Vitals. Among sports medicine surgeons, active Twitter/X and Instagram usage was also associated with a higher h-index compared to nonusers.
    Discussion: Social media involvement and overall online presence is positively associated with surgeon ratings and number of reviews and comments on physician rating websites, including Healthgrades, Google Reviews, and Vitals. Increased activity on Twitter/X and Instagram is also associated with an increased h-index. Social media involvement using web-based marketing tools continues to emerge in shoulder surgery by offering surgeons an outlet to reach patients and promote literature.
    Keywords:  Academic productivity; Fellowship; H-index; Online engagement; Patient ratings; Shoulder and elbow; Social media; Sports medicine
    DOI:  https://doi.org/10.1016/j.jseint.2024.11.006
  93. J Hand Surg Glob Online. 2025 Jul;7(4): 100616
    The Impact of Leadership in Gender Diversity of Annual Meeting Speakers in the American Society for Surgery of the Hand.
    Minji Kim, Ines C Lin, Helen G Hui-Chou.
       Purpose: The American Society for Surgery of the Hand (ASSH) is the largest membership organization for hand surgeons. In 2022, the ASSH annual meeting had a man president and men program chairs. In 2023, the ASSH annual meeting was led by a woman president and women co-chairs. In this study, we aimed to compare the gender and racial diversity of speakers and moderators between these 2 years.
    Methods: The programs for ASSH for 2022 and 2023 were collected from web searches and ASSH Annual meeting programs. Gender and race for each speaker were discerned based on perceived visual perceptions from photographs. Chi-square tests were performed to compare the gender and racial diversity between 2022 and 2023.
    Results: There were 620 and 587 speaking opportunities in years 2022 and 2023, respectively. Proportion of women speakers significantly increased from 23.1% to 33.2%, as did the proportion of women moderators (18.6% vs 38.0%). Racial distribution did not significantly change between 2022 and 2023. Percentages of panels with at least one woman speaker significantly improved between the two time points, from 66.7% to 87.1%.
    Conclusions: We found significant increases in the proportion of women speakers and panels with at least one woman speaker between the 2022 and 2023 annual meetings (P < .001). We propose that leadership diversity in annual meeting planning may account for these changes. Therefore, we encourage ongoing efforts to diversity through annual meeting planning and leadership committees as one strategy to achieve diversity, equity, and inclusion in our field.
    Type of study/level of evidence: Observational III.
    Keywords:  Conferences; Diversity; Hand surgery; Meetings; Speakers
    DOI:  https://doi.org/10.1016/j.jhsg.2024.07.006
  94. PLoS One. 2025 ;20(6): e0323356
    Network assortativity for a multidimensional evaluation of socio-economic territorial biases in university rankings.
    Loredana Bellantuono, Andrea Lo Sasso, Nicola Amoroso, Alfonso Monaco, Sabina Tangaro, Roberto Bellotti.
      University rankings are published on a regular basis and taken as a reference by a widespread audience of students, researchers, and companies. Nonetheless, rankings can be affected by socio-economic dragging effects, since they often fail to incorporate information on the variegated conditions in which scores are reached. This inability to capture structural inequalities can generate self-reinforcing awarding mechanisms, e.g. in performance-based funding distribution, that amplify existing gaps and prevent from recognizing achievements of universities in difficult or emerging contexts. In a previous study, we demonstrated the existence of a socio-economic territorial bias in general rankings, which rate the global performance of institutions. However, the interplay of the variety of territorial contexts and the different features of specific disciplines can give rise to more complex effects. In this work, we investigate the influence of the local socio-economic condition on the performance of universities in rankings, considering a multidimensional representation of the phenomenon, involving the dependence on subject, time, and type of ranking. Our findings show that bibliometric rankings are significantly more affected than reputational ones by socio-economic dragging, which strikingly emerges especially in the natural and life science areas. We conclude the analysis by decoupling territorial dragging effects from the achieved ranked scores. Universities that benefit the most from the mitigation of the socio-economic territorial bias are typically located in territories, mostly outside Western Europe and North America, hosting either a capital or other important cities.
    DOI:  https://doi.org/10.1371/journal.pone.0323356
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