bims-evares Biomed News
on Evaluation of research
Issue of 2025–08–24
fifty-two papers selected by
Thomas Krichel, Open Library Society
  1. FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges.
  2. Visualization and Bibliometric Analysis of the Research Progress and Trends of Air Embolism.
  3. Internationalization and Collaboration in Colombian Psychology During 2014-2023: A Bibliometric Analysis.
  4. Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis.
  5. Global research trends on epigenetics and cancer: A bibliometric analysis.
  6. A Bibliometric Analysis of Publications on the Prevalence of Chronic Pain in Children and Adolescents From 2009 to 2023.
  7. Research hotspots and global trends in respiratory syncytial virus over past five years.
  8. Global research status and trends of compulsive sexual behavior disorder: A comprehensive bibliometric analysis.
  9. Global research status, hotspots and prospects of ferroptosis in glioma: a scientometric analysis.
  10. Research on the association between beverages consumption and cancer.
  11. Global trends and hotspots in blood glucose management for elderly patients with diabetes: A bibliometric analysis (2000-2024).
  12. Physical activity and neuroinflammation: a bibliometric analysis of research progress and future perspectives.
  13. Trends of tDCS Research in India: A Bibliometric Analysis.
  14. Unveiling research landscapes in erectile dysfunction: a bibliometric analysis comparing basic scientific research and clinical studies.
  15. Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.
  16. Global Trends in Cadaver Donation and Medical Education Research: Bibliometric Analysis Based on VOSviewer and CiteSpace.
  17. Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis.
  18. Hotspot analysis and frontier exploration of biomechanical research on knee osteoarthritis: a bibliometric study and visualization analysis.
  19. Bibliometrics-Based Mapping of Research on the Role of miRNAs in Oral Cancer.
  20. Structural and temporal dynamics analysis of PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: History, research hotspots, and emerging trends.
  21. A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives.
  22. Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024.
  23. A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites.
  24. A bibliometric analysis of general surgery residents entering into vascular surgery.
  25. Trends in sleep dentistry research in Asia: A bibliometric analysis.
  26. Mapping Current Research Status and Emerging Frontiers of T-Cell Exhaustion: A Comprehensive Data-Mining-Based Study.
  27. Global trends in physical activity research of attention-deficit/hyperactivity disorder: A scientometric study (2000-2024).
  28. Global Research Trends in Artificial Intelligence and Type 2 Diabetes Mellitus: A Bibliometric Perspective.
  29. Exploring the Relationship Between Fragile X Syndrome and Autism: A Bibliometric Analysis of Global Research Trends.
  30. Bibliometric analysis of research on artificial İntelligence applications in breast cancer diagnosis.
  31. Bibliometric analysis of pathological mechanisms in Alzheimer's disease: Applications based on mouse models.
  32. Quality of life after third molar surgery: a bibliometric analysis of randomized clinical trials.
  33. Trends in research on relationship between root exudates and soil phosphorus: a bibliometric analysis.
  34. Mobile Interventions for Reducing Sedentary Behavior and Promoting Physical Activity Among Office Workers: Bibliometric Study.
  35. Exploring the Landscape of Operating Room Scheduling: A Bibliometric Analysis of Recent Advancements and Future Prospects.
  36. Global trends in machine learning applications for single-cell transcriptomics research.
  37. Evolving landscape of hepatitis C research in the Eastern Mediterranean Region: A comprehensive bibliometric analysis from 2004 to 2024.
  38. Bibliometric analysis of immunogenic cell death in hepatocellular carcinoma.
  39. Bibliometric analysis of highly pathogenic avian influenza research globally from 2003 to 2023.
  40. Mapping Key Nodes and Global Trends in AI and Large Language Models for Medical Education: A Bibliometric Study.
  41. A bibliometric study of the top 100 most cited articles on melanoma: insights into research trends and characteristics.
  42. An Assessment of the Journal of Bone and Joint Surgery Publication Trends From 2012 Through 2022.
  43. Prevalence and Success of Pediatric Orthopaedic Trainee Research Grants.
  44. From abstracts to published articles: Assessing the scientific publications from the annual meetings of the German Spine Society (DWG) in 2017, 2018, 2019, and 2022.
  45. Towards inclusive authorship: Analyzing author representation in PLOS Global Public Health front matter content.
  46. Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
  47. Association of completing an intercalated year-long research degree with post-graduation academic success.
  48. Systematic mapping and bibliometric analysis of meta-analyses on animal cognition.
  49. Scholarly Activity Among VA Podiatrists: A Cross-Sectional Study.
  50. Analysis of collaborative robot technology patent map and research on development trends.
  51. A bibliometric and systematic review of the global impact of air pollution on Alzheimer's disease: Insights from cohort studies.
  52. Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old.
  1. Discov Oncol. 2025 Aug 17. 16(1): 1570
    FLASH radiotherapy at a crossroads: a bibliometric perspective on progress and challenges.
    Peng Wang, Yugeng Gao, Can Chen, Xiaoxin Zhao, Yuying Zhang, Taorui Liu, Haoran Jiang, Zhe Wang, Xiang Zhao, Jianjun Li.
       BACKGROUND: Flash radiotherapy (FLASH-RT), an emerging modality utilizing ultra-high dose-rate (UHDR) irradiation (typically > 40 Gy/s), has demonstrated a unique capacity to preserve normal tissue integrity while maintaining tumor control efficacy compared to conventional radiotherapy. Despite exponential growth in FLASH-RT research over the past decade, its scientific landscape has not yet been systematically characterized through bibliometric analysis. This study only includes articles from the Web of Science Core Collection (WoSCC) and is limited to English-language publications, which may introduce database and language biases.
    METHODS: Relevant articles and reviews on FLASH-RT were retrieved from the WoSCC database. Bibliometric analysis and scientific knowledge mapping were performed using the R packages Bibliometrix, CiteSpace, and VOSviewer, in conjunction with the online analytical tools provided by Web of Science (WoS).
    RESULTS: A total of 572 publications from 2013 to 2025, spanning 179 countries/regions and involving 2,049 institutions, were analyzed. The United States, Switzerland, and China were the leading contributors. The University of Lausanne had the highest research output. These publications appeared in 96 different journals, with Medical Physics contributing the most studies. Among 2995 authors, Vozenin MC had the highest publication count and H-index, while Favaudon V's papers received the most citations. Frequent keywords included irradiation, flash radiotherapy, radiation therapy, and cells. Keyword clustering revealed eleven major research directions, primarily focusing on pencil beam scanning and dosimetry.
    CONCLUSION: This first bibliometric analysis of FLASH-RT research highlights key trends, influential contributors, and challenges. These findings provide valuable insights into research frontiers and hotspots, guiding future studies and collaborations.
    Keywords:  Bibliometric analysis; CiteSpace; FLASH radiotherapy; Ultra-high dose-rate; VOSviewer; Web of science
    DOI:  https://doi.org/10.1007/s12672-025-03400-7
  2. Undersea Hyperb Med. 2025 Second Quarter;52(2):52(2): 133-147
    Visualization and Bibliometric Analysis of the Research Progress and Trends of Air Embolism.
    Yuehong Ma, Wenying Lv, Shuyi Pan, Dazhi Guo.
       Objective: The etiology and diagnosis of air embolism (AE), including approaches for prevention and management based on experimental and clinical data, have been presented. However, these publications may not reach all the intended audience (e.g., surgeons), and thus, the use of bibliometric analyses is encouraged.
    Methods: We queried the Web of Science database using bibliometric analysis to identify publications related to AE from 1995 to 2022.
    Results: The literature search retrieved 2463 publications that met the inclusion criteria. In AE research, the total number of articles published every year was 80±16, and it increased gradually in recent years. Many published articles and most of the top ten research institutions (8/10) were from the USA (n = 826, 33.5%). The USA also has the highest citations and the most extensive cooperation with most countries. However, the proportion of the top ten journals is not too high, and the quality of these papers is not sufficiently good. The mean number of citations for the top ten articles was 105.8 (range: 68-298). Moreover, ten authors contributed to 146 manuscripts from eight countries. A total of 7926 keywords were found. Among these, 135 were hotspot keywords that appeared at least 20 times. The keywords with strong citation bursts changed from dog to risk factors of AE (7.66 versus 9.81).
    Conclusions: We explore the citation relevance and collaboration map and their hotspots in AE and provide a foundational understanding of the research progress and trends of AE.
    Keywords:   VOSviewer; air embolism; bibliometrics; visualization analysis
  3. Psychol Russ. 2024 ;17(4): 60-84
    Internationalization and Collaboration in Colombian Psychology During 2014-2023: A Bibliometric Analysis.
    Claudio Bustos Navarrete, Lina Villota Castillo, Astrid Sarmiento Quiñones, Ignacio Rojas Rodríguez, Lina Sandoval Moreno.
       Background: Bibliometric studies are essential for understanding the development of a discipline and thus establishing policies to promote evidence-based science. In the case of Colombian psychology, no studies have yet considered the productivity, collaboration, and internationalization of this discipline jointly. In this context, the role of Ministerio de Ciencia, Tecnología e Innovación (Minciencias) research groups in promoting collaboration within Colombia is particularly significant.
    Objective: To analyze the scientific productivity, degree of internationalization, and collaboration in Colombian psychology from 2014 to 2023.
    Design: A bibliometric study was conducted using data from Web of Science, Scopus, and SciELO, employing bibliometric indicators. A total of 4,196 Colombian psychology articles from 2014 to 2023 were analyzed, employing various indicators to assess productivity, internationalization, and collaboration.
    Results: The period was characterized by a sustained increase in productivity. An increase in internationalization was evident, as shown by a greater number of articles written in English and published in foreign journals, along with growing international collaboration, primarily with Spain and the United States. While Colombian-led research has increased, publications with foreign leading authors receive a substantially higher number of citations.
    Conclusion: This is the first study to incorporate Minciencias groups into the evaluation of research productivity within Colombian psychology. The study suggests that researchers are adapting to Minciencias's evaluation criteria, with a focus on collaboration and high-impact publications. Strengths include using multiple databases and rigorous data cleaning. Future research can explore international comparisons and the impact of internationalization on research focus.
    Keywords:  Colombia; bibliometrics; internationalization; psychology; scientific cooperation
    DOI:  https://doi.org/10.11621/pir.2024.0404
  4. Discov Oncol. 2025 Aug 18. 16(1): 1575
    Research trends and prospects of Circulating tumor DNA associated with colorectal cancer: a bibliometric analysis.
    Shusen Xia, Lixin Liu, Yi Zhou, Yanbin Zhu, Qian Dai, Hong Peng.
      Recent research has highlighted ctDNA as a crucial tool for screening, monitoring, and treating colorectal cancer, gaining significant attention. This study aims to map the research landscape via bibliometric analysis, identifying future trends and key areas of interest. We collected articles and reviews on ctDNA and colorectal cancer from the Web of Science Core Collection and Scopus, conducting bibliometric analysis and visualization using VOSviewer, CiteSpace, and R packages. A total of 1,730 publications were included in the bibliometric analysis. Of these, 325 were unique to WOS and 639 were unique to SCOPUS. The United States and China led in publication volume with 555 and 306 papers, respectively, while the United States and Italy had the highest citation counts, with 39,142 and 21,417 citations, respectively. The University of Texas MD Anderson Cancer Center was the most prolific institution. The journals Cancers and Frontiers in Oncology were the most frequently published. Bardelli A stood out as the most prolific and cited author. Cluster analysis revealed trending topics such as "minimal residual disease," "adjuvant chemotherapy," and "recurrence." This bibliometric analysis highlights significant advancements and emerging trends in the clinical application of ctDNA for colorectal cancer. The identified hotspots deserve further attention from researchers in this field.
    Keywords:  Bibliometric; Circulating tumor DNA; Colorectal cancer; CtDNA; VOSviewer
    DOI:  https://doi.org/10.1007/s12672-025-03394-2
  5. Medicine (Baltimore). 2025 Aug 15. 104(33): e43197
    Global research trends on epigenetics and cancer: A bibliometric analysis.
    Xinyi Zhong, Du Chen.
       BACKGROUND: Epigenetics in cancer has been a focus of intense research in the recent years. This phenomenon has attracted great interest because it offers potential targets for cancer therapy. To capture the intellectual landscape of this field, this article conducted a bibliometric analysis to assess the current status, frontiers and future trends of epigenetic research in cancers.
    METHODS: A bibliometric analysis was performed using data from the Web of Science Core Collection up to 2023. Analytical tools such as CiteSpace, VOSviewer, and the R package "bibliometrix" were employed for comprehensive data analysis and visualization. This process identified the publication of the articles, countries, authors, institutions, journals and keywords.
    RESULTS: The results showed that there were 51,742 articles from the WoSCC database during 1985 to 2023 for cancer epigenetics. The number of epigenetic cancer-related publications has increased annually. The most contributed country is the United States, with 850,726 citations and 55 average article citations. China ranks second, with 413,386 citations and an average of 44.7. The most productive institutions were from the USA. Plos One (1020), International Journal of Molecular Sciences (957), and Cancers (945) were the top 3 contributing journals. The top 3 most common keywords were "DNA methylation," "expression" and "cancer." Research hotspots within these themes highlight intensive areas of study and the potential for significant breakthroughs.
    CONCLUSIONS: This study presents an in-depth overview of the current state of epigenetics in cancers research. And the purpose of this review will be to understand the characteristics of bibliometric analyses of epigenetic cancers and anticipate the progress in understanding this field.
    Keywords:  VOSviewer; bibliometrics; cancer; citespace; epigenetic
    DOI:  https://doi.org/10.1097/MD.0000000000043197
  6. Paediatr Neonatal Pain. 2025 Sep;7(3): e70013
    A Bibliometric Analysis of Publications on the Prevalence of Chronic Pain in Children and Adolescents From 2009 to 2023.
    Justine Dol, Christine T Chambers, Jennifer A Parker, Perri R Tutelman, Brittany Cormier.
      Bibliometric reviews explore patterns in publications in a given research area by exploring trends over time and the contributions by citations, such as relationships between authors and publications. Despite "chronic pain" being the second most common keyword in pain research, no bibliometric reviews have focused on publication trends related to the prevalence of chronic pain in children and adolescents. A bibliometric analysis was conducted with articles included in a systematic review and meta-analysis on the prevalence of pediatric chronic pain to identify the recent trajectory of the field and guide future directions. Publication bibliometrics data from the articles were extracted and analyzed (e.g., gender of authors, citation counts, and countries) and was visualized in VOSViewer. Among 119 studies, the number of publications per year ranged from 4 (2023) to 11 (2014, 2021) with an average of 8/year. Articles were cited on average 36.6 times (SD = 51.7, range 0-380) with 5058 unique citations. There were 74 different journals represented, with most publishing only 1 article (n = 52, 70%). Seventy countries were represented in prevalence data, 78% from high-income countries; fifteen (21.4%) had only one data point, primarily from low- and lower-middle income countries. There were 109 different corresponding authors, with only 1 corresponding author who had more than 2 published articles. There was relative gender equity in terms of first and corresponding author. There was little to no collaboration between author groups identified. Despite a steady number of articles published over the 14-year period, the literature on the prevalence of pediatric chronic pain appears fragmented with articles published in a wide variety of journals. Prevalence data from low- and lower-middle-income countries were under-represented. Future work should focus on expanding evidence in underrepresented areas and greater collaboration among research groups to collect prevalence data in geographical areas where data gaps exist.
    Keywords:  adolescent; bibliometric; chronic pain; pediatric
    DOI:  https://doi.org/10.1002/pne2.70013
  7. Front Microbiol. 2025 ;16 1599093
    Research hotspots and global trends in respiratory syncytial virus over past five years.
    Xiaoli Tao, Zhuping Ma, Hongxia Yuan, Wei Zhao, Jingyu Liu, Jing Tian.
      Respiratory syncytial virus (RSV) is the main cause of acute lower respiratory tract infections in children under 2 years old. This bibliometric analysis is used to determine the characteristics, hotspots, and frontiers of RSV global scientific output over the past 5 years. In this study, the Science Citation Index Expanded (SCI-Expanded) version from the Web of Science Core Collection (WoSCC) for publications and record information published from 2020 to 2024 was retrieved. Bibliometric software package was used to analyze the bibliometric indicators, and the research trends and hotspots of RSV were visualized by VOSviewer and Citespace. We assessed paper influence with the Global Citation Score (GCS). A total of 7,238 articles and comments were searched. The USA is the most productive country in the field of RSV research and also the country with the closest cooperation with other countries and institutions. The most influential journal in this field is "VIRUSES BASEL" with 246 publications. The co-citation analysis of references showed that the RSV-related topics with the highest focus are "covid-19 pandemic," "respiratory syncytial virus prefusion," "American academy," and "protein vaccine." From 2020 to 2024, keyword cluster and keyword burst analyses showed that "Respiratory Syncytial Virus," "Infection," and "Children." "Viral co-infection," "anti-virus," and "vaccines" are currently research hotspots. The research area in this field is mainly distributed among "Immunology," "Pediatrics," "Pharmacology Pharmacy," and "Biochemistry Molecular Biology." Our study highlights the trends and hotspots in the field of RSV research over the past 5 years. Identifying the most critical indicators in the field of RSV research would be able to help researchers in this field better understand RSV and make decisions.
    Keywords:  VOSviewer; bibliometrics; research hotspots; respiratory syncytial virus; trends
    DOI:  https://doi.org/10.3389/fmicb.2025.1599093
  8. J Behav Addict. 2025 Aug 16.
    Global research status and trends of compulsive sexual behavior disorder: A comprehensive bibliometric analysis.
    Wenwen Zhang, Pengshuo Wang, Boyuan Gao, Ziqi Wang.
       Background: Compulsive sexual behavior disorder (CSBD) is a mental health condition that has attracted significant research attention, especially following its inclusion in the eleventh revision of the International Classification of Diseases (ICD-11) by the World Health Organization. Despite this recognition, the field remains fragmented with ongoing debates about its classification and a lack of comprehensive cross-cultural research. In this study, bibliometrics was used to characterize the development status of CSBD over the past 25 years and to identify key research hotspots and future trends.
    Methods: This study collected data from the Web of Science Core Collection and analyzed the literature related to CSBD from 2000 to 2024. A total 2,261 publications were examined for their characteristics, including annual publication volume, countries/regions, institutions, authors, journals, references, and keywords. Several bibliometric and visualization tools (e.g., VOSviewer, CiteSpace, Scimago Graphica, and Pajek) were used to conduct the analysis of co-authorship, co-citation, co-occurrence and descriptive.
    Results: The analysis identified a consistent upward trend in research interest in CSBD, particularly after its inclusion in ICD-11. Co-occurrence analysis of 82 author keywords with frequencies of more than 12 resulted in 5 clusters: (1) competing conceptualizations of CSBD; (2) comorbidity of CSBD with other psychiatric disorders; (3) assessment, risk factors, and treatment; (4) gender differences and sexual health; (5) CSB caused by neurological diseases. Moreover, the findings of countries/regions analysis indicate that publications are mainly from Western, educated, industrialized, rich, and democratic (WEIRD) countries/regions, and collaborative networks mainly connect countries from the North America and Europe. Despite its growing recognition, the field still lacks interdisciplinary collaboration and comprehensive studies from non-WEIRD contexts, highlighting a need for broader, cross-cultural research.
    Conclusions: This study comprehensively maps global research trends in CSBD, identifies critical knowledge gaps, and provides a foundation for future research. By synthesizing the current research status, it aims to guide researchers toward emerging topics and foster a more cohesive understanding of CSBD.
    Keywords:  behavioral addiction; bibliometric analysis; compulsive sexual behavior disorder; hypersexual disorder; research trends; visualization techniques
    DOI:  https://doi.org/10.1556/2006.2025.00059
  9. Front Cell Neurosci. 2025 ;19 1614710
    Global research status, hotspots and prospects of ferroptosis in glioma: a scientometric analysis.
    Jing Liu, Zefeng He, Zhansen An, Shiduo Li, Liang Liu, Yingzi Liu.
       Objective: The primary approach to the treatment of glioma involves surgical intervention, which is often complemented by radiotherapy, chemotherapy, and electric field therapy. Nevertheless, the prognosis for many patients remains poor. There exists an urgent necessity to identify novel replacement therapy strategies. A great breakthrough has been made in the study of ferroptosis in gliomas. The objective of this study is to conduct a systematic review of the current research status of ferroptosis in gliomas utilizing bibliometric analysis.
    Method: Publications related to glioma and ferroptosis from 2014 to 2025 were retrieved from the Science Core Collection (WoSCC) database. A bibliometric analysis was conducted using VOSviewer, CiteSpace, and the R package.
    Results: A total of 440 publications from 38 countries, with China leading the way, were included in the analysis. The number of publications related to ferroptosis in gliomas has been steadily increasing each year. The primary research institutions contributing to this field include Central South University, Nanjing Medical University, Shandong University, and Southern Medical University. Frontiers in Oncology is the leading journal for ferroptosis research in gliomas, while Cell is the most frequently cited journal in this field. These publications were authored by 2,921 individuals. Among them, Lu Shan, Wang Xuanzhong, Chen Qianxue, Sun Qian, and Xu Yang contributed the highest number of articles, while Dixon, SJ was the most frequently co-cited author. Studying the mechanisms, targets, and immunotherapy of ferroptosis in gliomas are major topics in this field. "Oxidative stress," "gpx4," and "autophagy" are popular keywords in recent years. In addition, "chemotherapy" and "miRNA" are emerging topics in this field that are closely related to this study and warrant greater attention.
    Conclusion: This is the first bibliometric analysis of the relationship between ferroptosis and glioma conducted over the past 11 years. The analyzed studies elucidate the regulatory mechanisms of ferroptosis and its implications in cancer cells, identify emerging research hotspots and Frontiers in recent years, and offer valuable references for scholars investigating ferroptosis in glioma, thereby facilitating the exploration of novel alternative treatment options.
    Keywords:  CiteSpace; VOSviewer; bibliometrics; ferroptosis; glioma
    DOI:  https://doi.org/10.3389/fncel.2025.1614710
  10. Front Med (Lausanne). 2025 ;12 1624496
    Research on the association between beverages consumption and cancer.
    Alapati Waili, Shayidan Abdunayim, Maidina Talifu, Zhaoxin Zhuo, Maidina Ruzimaimaiti, Liwen Tao, Wei Han.
       Background: Cancer is the second leading cause of global death in the 21st century. Despite international efforts such as the European Code Against Cancer and the World Health Organization's Global Action Plan, there are still significant gaps in translating policies into tangible outcomes. Diet, especially sugar intake, is a key modifiable factor affecting cancer risk, and the consumption of various beverages is associated with cancer susceptibility. This study uses bibliometric methods to analyze the research on the relationship between beverage consumption and cancer, aiming to provide a macro perspective and guide future research.
    Methods: We searched for articles related to beverage consumption and cancer published between January 2005 and January 2025. Utilizing bibliometric methods, we analyzed the publications using R software, VOSviewer, and CiteSpace. Our analysis encompassed an examination of the publication volume, citation behavior, and co-authorship networks, aiming to reveal the research dynamics and trends within the field.
    Results: We conducted a bibliometric analysis of 998 articles and found that the number of publications related to beverage consumption and cancer has been increasing steadily year by year. Among many countries, the United States and China are the main contributors in this field. Among the top 10 institutions, the National Cancer Institute has published the most research results, with a total of 111 papers, indicating its significant influence in this research area. The citation bursts of keywords reveal that the current and future research focus is on exploring the complex relationship between specific dietary factors and various types of cancer.
    Conclusion: Existing research indicates that over the past 20 years, there has been a steady increase in the number of research papers on beverage consumption and cancer. In this study, we conducted a comprehensive and impartial analysis of the relevant literature available in the WoSCC. We utilized various software tools to perform quantitative and visual analyses, such as examining the number of publications, citation counts, countries, institutions, journals, authors, cooperative relationships, and keywords. These findings enable researchers to identify emerging topics and frontiers in the field of beverage consumption and cancer, providing scholars with valuable insights and references.
    Keywords:  WOSCC; beverages; bibliometrics; cancer; cancer risk
    DOI:  https://doi.org/10.3389/fmed.2025.1624496
  11. Medicine (Baltimore). 2025 Aug 15. 104(33): e43919
    Global trends and hotspots in blood glucose management for elderly patients with diabetes: A bibliometric analysis (2000-2024).
    Li Zhou, Lubi He.
       BACKGROUND: Effective management of blood glucose levels in elderly patients with diabetes is crucial in healthcare and has seen significant advancements. However, there is a lack of bibliometric analyses in this field. This study aimed to provide a comprehensive overview through bibliometric analysis.
    METHODS: A bibliometric analysis was conducted using the Web of Science Core Collection to identify research trends in blood glucose management for elderly patients with diabetes from 2000 to 2024. The analysis utilized VOSviewer version 1.6.20, CiteSpace version 6.3.R1, and R version 4.3.3 to visualize collaboration networks and emerging research trends.
    RESULTS: A total of 11,826 publications were analyzed, sourced from 134 countries and 228 institutions between 2000 and 2024. There has been a consistent increase in publications, particularly from 2020 to 2022. The United States was the leading contributor, with 2436 publications, while Harvard University had the highest output at 829 publications. Among the journals, Diabetes Care was the most impactful based on its high Hirsch index. Influential authors included Beck Roy W and Khunti Kamlesh. Keyword analysis identified "continuous glucose monitoring," "weight," "progression," "young adults," "classification," and "time in range" as primary research themes since 2017.
    CONCLUSION: This bibliometric analysis provides a detailed overview of blood glucose management in elderly diabetic patients. Key focus areas such as "continuous glucose monitoring," "time in range," and "weight" have gained significant attention. Future research should further explore these themes, especially the role of continuous glucose monitoring and the concept of time in range in clinical practice.
    Keywords:  bibliometric analysis; blood glucose management; collaborative networks; diabetes; research trends
    DOI:  https://doi.org/10.1097/MD.0000000000043919
  12. Front Aging Neurosci. 2025 ;17 1602724
    Physical activity and neuroinflammation: a bibliometric analysis of research progress and future perspectives.
    Yeting Zhang, Huangyan Li, Jiangxi Yang, Huan Ma.
       Background: Neuroinflammation is a common pathological feature of neurodegenerative and psychiatric diseases and is closely related to the dysfunction of the nervous system. In recent years, an increasing number of studies have shown that physical activity (PA) has a significant regulatory effect on neuroinflammation. However, a comprehensive analysis of research in this field is currently lacking, including the evolution of knowledge structures, interdisciplinary trends, and dynamic shifts in research hotspots.
    Methods: This study retrieved relevant literature from the Web of Science Core Collection database for the period from 2004 to 2025. The search strategy was TS = (("physical activit*" OR exercis* OR "exercise training") AND ("neuroinflammat*" OR "neuro inflammatory" OR "neuro-inflammatory")), with the document type limited to Articles and Reviews. After screening, a total of 661 eligible articles were included for bibliometric analysis. The analysis tools used were the Bibliometrix R package and VOSviewer, which were employed to visualize the results of the literature analysis.
    Results: From 2004 to 2025, the number of publications in this field showed a yearly increasing trend, with an annual growth rate of 15.05%. China and the United States were the main contributing countries, publishing 122 and 111 articles, respectively. In terms of journals, the International Journal of Molecular Sciences ranked first with 36 articles and a total of 799 citations. Among the institutions, Karolinska Institute led the way in terms of citation counts, amassing a total of 391 citations. Regarding author keywords, "Alzheimer's disease," "microglia," and "older adults" were the three most frequently occurring keywords. Research hotspots have gradually shifted from the early focus on hippocampal function and neuroinflammation mechanisms to current directions such as neurodegenerative diseases, microglial regulation, and the gut-brain axis.
    Conclusion: This study systematically reviewed the research progress in the field of PA and neuroinflammation from 2004 to 2025 using bibliometric methods and revealed the research hotspots, trends, and thematic evolution in this field. It provides a systematic scientific basis for scholars to understand the field, optimize research directions, and develop intervention strategies.
    Keywords:  bibliometric analysis; exercise; neurodegenerative disease; neuroinflammation; physical activity
    DOI:  https://doi.org/10.3389/fnagi.2025.1602724
  13. Indian J Psychol Med. 2025 Aug 15. 02537176251364384
    Trends of tDCS Research in India: A Bibliometric Analysis.
    Sujita Kumar Kar, Adarsh Tripathi, Pritanshi Jeswani, Vikrant Patel.
       Background: Transcranial Direct Current Stimulation (tDCS) is a noninvasive technique of neuromodulation used in the treatment of various psychiatric and neurological conditions. This bibliometric analysis aimed to comprehensively capture the trends in tDCS research with India as the affiliation country.
    Methods: A bibliometric analysis was conducted. Data for studies conducted on tDCS in India were extracted using Scopus from January 1, 2011, to March 27, 2025. Articles were analyzed for publication count, citation trends, institutional affiliations, contributing authors, and the journals in which they were published.
    Results: The findings indicate a growing number of studies being published on tDCS in India. The maximum number of articles was original research studies, followed by review articles. The Asian Journal of Psychiatry and the Indian Journal of Psychiatry were the leading journals that published articles on tDCS. NIMHANS (Bangalore), AIIMS (Delhi), and King George's Medical University (KGMU) (Lucknow) were the institutes with the highest number of publications on the subject matter.
    Conclusions: There is a rise in tDCS research; however, a discrepancy exists between the number of articles being published in various parts of the country. An inter-institutional collaboration is suggested to promote further research and provide a comprehensive understanding of the clinical applicability and standardized procedures for tDCS administration in various psychiatric and neurological conditions.
    Keywords:  Bibliometrics; India; neuromodulation; transcranial direct current stimulation
    DOI:  https://doi.org/10.1177/02537176251364384
  14. Sex Med Rev. 2025 Aug 17. pii: qeaf048. [Epub ahead of print]
    Unveiling research landscapes in erectile dysfunction: a bibliometric analysis comparing basic scientific research and clinical studies.
    Zhongjie Zheng, Yi Lu, Yan Chen, Qianxi Chen, Eric Chung, Hui Jiang, Kai Hong, Hongjun Li, Haocheng Lin.
       INTRODUCTION: Erectile dysfunction (ED) is a highly prevalent male sexual disorders, affecting million of men worldwide. Given the volume of literature in ED, bibliometric analyses will provide an important resource to highlight landmark articles.
    OBJECTIVES: To evaluate the publication trends and impacts between basic scientific research and clinical studies through bibliometric analysis of ED literature between 1998 and 2023.
    METHODS: We searched for articles in the Web of Science database from 1 January 1998 to 31 December 2023 using MeSH terms specific to ED. Relevant articles were divided into basic scientific research and clinical studies. A bibliometric analysis was performed by using "Citespace" and "VOSviewer" software.
    RESULTS: A total of 6450 studies were identified, with 4808 in clinical studies and 1642 basic scientific research. The USA has the highest publication rate with 1851 articles, followed by China (853) and Italy (635). The University of California, San Francisco ranked first in basic scientific research with 68 research papers, while the University of Florence led the clinical research with 133 papers. The Journal of Sexual Medicine and the Journal of Urology were found to have the highest academic influence. Clinical research papers receive more citations than basic scientific ones. Notably, vardenafil emerged as the most frequently used keyword in ED research over the past decade, ranking first in both basic scientific and clinical studies.
    CONCLUSION: Bibliometric analyses can provide an in-depth analysis in distinguishing ED literature. There is a need to foster multi-center international collaborations and new emphasis on novel technology and recent scientific advances.
    Keywords:  bibliometrics; biomedical research; clinical study; erectile dysfunction; journal impact factor; peer influence
    DOI:  https://doi.org/10.1093/sxmrev/qeaf048
  15. Parkinsons Dis. 2025 ;2025 6870215
    Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.
    Yingni Jin, Jiayi Fu, Xiaojun Guan, Tao Guo, Xiaojun Xu.
      Background: Parkinson's disease (PD), a progressive neurodegenerative disorder marked by motor and nonmotor symptoms, with resting-state fMRI (rsfMRI) proving pivotal in identifying neural circuit abnormalities and functional connectivity patterns, paving the way for a more personalized, precision medicine approach to PD diagnosis and treatment. Methods: Given its significance, this study conducted a bibliometric analysis to systematically map the intellectual landscape of rsfMRI applications in PD research. Relevant publications were sourced from the Web of Science Core Collection database from January 1, 2009, to July 18, 2024, and restricted to English-language articles and review articles. Utilizing VOSviewer and CiteSpace software, the analysis covered publication distributions across countries, institutions, and authors, along with co-citation patterns among co-authors and journals, keyword co-occurrence, and burst detection. Results: A total of 658 publications from January 1, 2009, to July 18, 2024, were identified, showing a gradual increase in annual publication and citation volume in earlier years. Notably, a decline emerged in 2023, highlighting the need for research paradigm shift to drive further progress. Among 45 countries and 865 institutions, China, led in publication and citation counts at both the institutional and author levels, with neuroscience-related journals playing a key role in advancing this field. Keyword analysis identified emerging research frontiers, including disease heterogeneity, early detection, symptom-specific mechanism exploration, and treatment evaluation. Conclusions: Results from this bibliometric analysis systematically elucidates the historical development, research progress over the years, and current research hotspots in rsfMRI studies of PD, thereby offering valuable guidance for future research endeavors in this field.
    Keywords:  CiteSpace; Parkinson's disease; VOSviewer; bibliometrics; resting-state fMRI
    DOI:  https://doi.org/10.1155/padi/6870215
  16. JMIR Med Educ. 2025 Aug 18. 11 e71935
    Global Trends in Cadaver Donation and Medical Education Research: Bibliometric Analysis Based on VOSviewer and CiteSpace.
    Xianxian Zhou, Hua Xiong, Yi Wen, Fang Li, Dexi Hu.
       Background: The cadaver serves as a crucial resource in medical education, research, and clinical practice, as well as a vital foundation for fundamental medical experimental teaching.
    Objective: This study aims to use bibliometric analysis to create a knowledge map of cadaver donation in medical education, identify global trends, anticipate future research directions, and offer a foundation for upcoming investigations.
    Methods: Articles and review papers concerning cadaver donation and medical education, with a final search cutoff of January 10, 2025, were systematically retrieved from the Web of Science Core Collection database. Two reviewers carefully examined the initial set of articles based on titles and abstracts to exclude irrelevant ones. A quadratic regression model was used to examine the annual publication data. The model's goodness of fit was assessed using the R2 value, and the statistical significance of the findings was determined through the P valu. The selected publications were then analyzed and visualized for country, institution, author, reference, journal, and keywords using CiteSpace 6.3R3, VOSviewer 1.6.19, and the Online Analysis Platform of the Literature Metrology Database.
    Results: The quadratic regression model yielded the equation Y=0.1586X²-633.9X+633395, indicating a substantial increase in the number of publications over time (R2=0.9575, P<.05). The model forecasts that the publication count will reach 107 by 202. This upward trend is statistically significant, highlighting a notable rise in research interest and activity within this field over time. The United States was a major contributor, accounting for 21.2% (303/1114) of all publications. In terms of continents and faiths, Europe and Christianity contributed the most, while McGill University and The University of Sydney were the leading institutions. Prominent authors in this field included De Caro Raffaele, Macchi Veronica, Porzionato Andrea, Stecco Carla, and Dhanani Sonny. The most frequently cocited reference was "Bodies for Anatomy Education in Medical Schools: An Overview of the Sources of Cadavers Worldwide." The journal Anatomical Sciences Education published the most articles in this area and received the highest citation count. Cluster analysis of keywords revealed that "kidney transplantation," "gross anatomy education," and "brain death" were key research topics, while burst analysis of keywords identified "public perception" and "anatomical science" as emerging areas of investigation.
    Conclusions: This research presents a distinctive bibliometric approach to cadaver donation within medical education, setting it apart from previous studies by delivering an extensive global overview of trends and influential contributors in this domain. The results emphasize the increasing global interest and collaborative efforts surrounding cadaver donation, while also offering fresh perspectives on emerging topics like public perception and anatomical sciences. This paper serves as an important reference for researchers, policymakers, and educators, supporting the development of future strategies to enhance cadaver donation programs and further medical education.
    Keywords:  VOSviewer; bibliometric analysis; cadaver donation; citespace; medical education; medical knowledge; medical student; medical training
    DOI:  https://doi.org/10.2196/71935
  17. Discov Oncol. 2025 Aug 18. 16(1): 1572
    Ferroptosis and ovarian cancer: a bibliometric study and visualization analysis.
    Hongwang Yuan, Zhanyan Hua, Hua Zhang, Dingwen Xu.
       BACKGROUND: Ovarian cancer ranks first among malignant tumors in the female reproductive system. Ferroptosis plays a crucial role in the occurrence, development, and treatment of ovarian cancer. However, research focusing on the bibliometric analysis of ferroptosis in ovarian cancer remains scarce. This study employs bibliometric methods to analyze research trends related to ferroptosis in the field of ovarian cancer, providing direction for scholars and clinical practitioners.
    METHODS: Articles regarding ferroptosis and ovarian cancer were retrieved from the Web of Science Core Database up to November 6, 2024. After rigorous screening, bibliometric analysis utilized VOSviewer and CiteSpace, while CoreMine facilitated text mining in relation to drugs and genes significantly associated with ovarian cancer and ferroptosis.
    RESULTS: The publication volume of articles on ferroptosis and ovarian cancer has shown a yearly increase, significantly surging after 2022. The three countries with the highest publication outputs are China, the United States, and Japan. The top ten institutions with the most publications are all from China. The ten most frequently mentioned keywords are ferroptosis, ovarian cancer, cell death, apoptosis, expression, death, iron, resistance, metabolism, and cells. Text mining reveals that cisplatin, along with the genes/proteins SLC7A11 and GPX4, significantly correlates with both ovarian cancer and ferroptosis.
    CONCLUSIONS: Our article uses bibliometric methods to reveal publication trends, national distributions, regional collaborations, and recent research hotspots related to the correlation between ferroptosis and ovarian cancer. This study provides objective data as a reference for scientific research and clinical work concerning ferroptosis and ovarian cancer.
    Keywords:  Bibliometric analysis; Ferroptosis; Ovarian cancer; Publication
    DOI:  https://doi.org/10.1007/s12672-025-03332-2
  18. J Orthop. 2025 Nov;69 288-304
    Hotspot analysis and frontier exploration of biomechanical research on knee osteoarthritis: a bibliometric study and visualization analysis.
    Zhangjie Xu, Xiaoli Chen, Jiaojiao Wu, Yixin Chen, Zhaomeng Hou.
       Objective: This study employs bibliometric and visualization analysis to systematically investigate research hotspots and emerging trends in the biomechanics of knee osteoarthritis (KOA).
    Methods: This study utilizes the Web of Science Core Collection (WoSCC) as the data source, employing a keyword-based search strategy to retrieve literature on the biomechanics of KOA published over the past two decades. Bibliometric analyses are conducted using tools such as CiteSpace and VOSviewer.
    Results: A total of 1932 articles were included in the analysis. Research outputs from the United States have been particularly prominent, setting a benchmark for the global academic community. Institutions such as the University of Melbourne and Stanford University have exhibited notable academic leadership. Professors Bennell KL and Andriacchi TP, identified as highly productive authors, have been frequently cited. Journals including Gait Posture and Osteoarthr Cartilage have served as key platforms for knowledge dissemination and academic dialogue. Current research foci are centered on keywords such as total knee arthroplasty, outcomes, injury, baseline, exercise, meniscus, MRI, risk, and knee adduction moment (KAM). These themes reflect contemporary research activity and suggest emerging frontiers. As biomechanical investigations deepen, the pathogenesis of KOA is anticipated to be more fully understood, offering a robust scientific foundation for clinical practice.
    Conclusions: This study employs bibliometrics and visualization analysis to conduct a comprehensive examination of hotspot issues and frontier trends in the biomechanics of KOA, offering researchers a structured understanding of research trajectories and trend insights.
    Keywords:  Bibliometric; Biomechanics; CiteSpace; Knee osteoarthritis; VOSviewer; Visual analysis
    DOI:  https://doi.org/10.1016/j.jor.2025.08.004
  19. J Oral Pathol Med. 2025 Aug 18.
    Bibliometrics-Based Mapping of Research on the Role of miRNAs in Oral Cancer.
    Yujing Wang, Rujie Shi, Baisheng Wang, Kun Li.
       BACKGROUND: MiRNAs have essential research value and broad clinical application prospects in oral cancer.
    AIMS: We provided a comprehensive understanding of trends, current features, and priorities in the field of miRNA and oral cancer research based on bibliometrics.
    MATERIALS AND METHODS: Reference records were obtained from the Web of Science core collection and analyzed using CiteSpace 6.2.4, VOSviewer 1.6.20, and GraphPad Prism 8.
    RESULTS: Results showed that between 2008 and 2024, a total of 1149 publications in the database were retrieved to study the role of miRNAs in oral cancer. The annual number of publications showed an increasing trend from year to year, peaking in 2021. Among them, China (470 articles), China Medical University (37 articles), and the journal Oral Oncology demonstrated the highest research productivity in terms of countries (regions), institutions, and journals.
    DISCUSSION: Keywords and cited literature indicate that the current research focus is mainly on microenvironmentally- derived miRNAs as potential diagnostic and therapeutic targets for oral cancer. Recent studies have gradually focused on the experimental study of drug delivery systems of miRNAs in treating oral cancer, which may become one of the important research directions in the future.
    CONCLUSIONS: Thus, by searching the literature in the field of miRNAs and oral cancer from the Web of Science core collection and performing bibliometric analysis, the development of research and research hotspots in the last two decades was mapped out. This will provide valuable references and guidelines for relevant scholars and researchers to explore the direction in future research endeavors.
    Keywords:  Web of Science; bibliometrics; miRNAs; oral cancer
    DOI:  https://doi.org/10.1111/jop.70037
  20. Hum Vaccin Immunother. 2025 Dec;21(1): 2540143
    Structural and temporal dynamics analysis of PD-1/PD-L1 immunotherapy in hepatocellular carcinoma: History, research hotspots, and emerging trends.
    Talaiti Tuergan, Aimitaji Abulaiti, Yingmei Shao, Tuerganaili Aji.
      This research aims to explore the historical evolution, key research areas, and new trends in PD-1/PD-L1 immunotherapy for hepatocellular carcinoma (HCC) over the last twenty years, focusing on structural and temporal dynamics. The Web of Science Core Collection (WoSCC) database was used to gather studies on PD-1/PD-L1 immunotherapy for HCC.CiteSpace and HistCite were utilized for a bibliometric analysis to investigate the historical progression, research evolution, and emerging trends in this area. In the last two decades, 2804 papers on PD-1/PD-L1 immunotherapy in HCC have been published, comprising 541 reviews and contributions from 13,796 authors across 2,659 institutions. Since 2014, the number of annual publications has significantly increased, with extensive international collaboration. Several active research topics have emerged, covering 72 disciplines, generating 561 keywords, and 1,199 articles that experienced citation bursts. Cluster analysis of keywords revealed five emerging subfields: lenvatinib, immune escape, immne checkpoint inhibitors, prognostic models, and tumor microenvironment. According to the "Timeline visualization of references," classic topics include CMTM6, regulatory T cells, liver transplantation, and bioinformatics analysis, while emerging topics include prognosis, lenvatinib, transarterial chemoembolization, hepatic arterial infusion chemotherapy, and single-cell RNA sequencing. This study sheds light on the current status and developing trends in PD-1/PD-L1 immunotherapy research for HCC, offering researchers valuable insights to identify crucial areas and explore new research directions.
    Keywords:  Hepatocellular carcinoma; PD-1/PD-L1; bibliometric; immunotherapy
    DOI:  https://doi.org/10.1080/21645515.2025.2540143
  21. Front Oncol. 2025 ;15 1593006
    A bibliometric analysis of inflammation and thyroid carcinoma: research trends and future perspectives.
    Yanhui Feng, Caiqi Huang, Xiaoman Liu, Zhesi Xiao, Lu Wang, Zhengjia Lu, Jia Ming.
       Background and objectives: Thyroid carcinoma, one of the most prevalent endocrine malignancies, has witnessed a gradual increase in incidence in recent years. Accumulating evidence has demonstrated that inflammation plays a pivotal role in the pathogenesis, progression, and prognosis of thyroid carcinoma, with a significant association between certain malignancies and chronic inflammatory processes. This study conducts a bibliometric analysis of literature on inflammation and thyroid carcinoma over 24 years, aiming to identify trends and research dynamics. The findings are expected to deepen understanding of thyroid carcinoma mechanisms and guide new therapeutic strategies.
    Methods: We used the advanced search function of the Web of Science Core Collection to systematically screen and curate articles on inflammation and thyroid carcinoma published between 2000 and 2024. Using Microsoft Excel 2019, we analyzed and visualized publication volume and growth trends. For co-occurrence and clustering analysis of countries, institutions, authors, journals, references, and keywords, we employed VOSviewer, CiteSpace, and the 'bibliometrix' package in R. Keyword visualization identified 10 major clusters, including sodium iodide symporter, total thyroidectomy, peroxisome proliferator-activated receptor, papillary thyroid microcarcinoma, therapeutic radiopharmaceuticals, zoological gardens, endoscopic thyroidectomy, mixed cryoglobulinemia, fine needle aspiration, and clinical evaluation. The most frequent keywords were cancer, thyroid cancer, and inflammation.
    Results: We included a total of 1,441 articles published between 2000 and 2024, contributed by 8,326 authors from 2,054 institutions across 70 countries. These articles were published in 625 journals, encompassing 59,808 references and 6,340 keywords. The publication output demonstrated a consistent upward trend over the study period. Among the contributing nations, China emerged as the most prolific country in terms of publication volume. The leading institution was the University of Pisa in Italy. The most productive author was Antonelli, Alessandro, and the leading journal was Thyroid.
    Conclusion: This bibliometric analysis shows that research on inflammation and thyroid carcinoma is a rapidly evolving field, marked by diverse themes and in-depth studies. Advances in technology and extensive research are expected to clarify how inflammation drives thyroid carcinoma initiation and progression. This deeper understanding will lead to new approaches in diagnosis, prevention, and treatment of thyroid carcinoma.
    Keywords:  CiteSpace; VOSviewer; Web of Science; bibliometric analysis; inflammation; thyroid carcinoma
    DOI:  https://doi.org/10.3389/fonc.2025.1593006
  22. Front Med (Lausanne). 2025 ;12 1615753
    Research trends and topics on sepsis immunosuppression: a bibliometric and visual analysis of global research from 2004 to 2024.
    Ji Yin, Yantong Wan, Guangqin Chen, Nanhong Li, Fei Liu, Haihua Luo, Yijing Li, Shan Li, Yong Jiang.
       Background: Sepsis, a condition characterized by critical organ impairment resulting from dysregulated response to infection, remains a leading cause of mortality globally. Immunosuppression significantly dictates the clinical trajectory and ultimate prognosis in sepsis. Research on sepsis-related immunosuppression has gained substantial attention in recent years. However, a comprehensive and objective analysis of the current state of research remains scarce. This study employs bibliometric techniques and knowledge mapping to provide a visual analysis of trends and developments in sepsis immunosuppression, offering a systematic overview for researchers in the field.
    Objectives: This study aims to: (1) Quantitatively characterize global publication trends, key contributors (countries/institutions/journals/authors), and collaborative networks in sepsis immunosuppression research (2004-2024); (2) Identify current hotspots and future directions in this field.
    Materials and methods: Articles and reviews related to sepsis immunosuppression were sourced from the Web of Science Core Collection via subject-specific searches. Bibliometric analyses were executed using Excel 365, CiteSpace, VOSviewer, and Bibliometrix (R-Studio's R-Tool).
    Results: From January 1, 2004, to March 22, 2024, 3,082 articles on sepsis immunosuppression authored by 16,545 individuals across 116 institutions from 30 countries were identified. Collaborative network analysis highlights the United States as the leading contributor, with key institutions including the University of Florida and Washington University. Strong international collaboration is evident, particularly between the United States and China, as well as the United States and Germany. Frontiers in Immunology emerged as the most prolific journal, while Journal of Immunology garnered the highest co-citation frequency. Guillaume Monneret has published the greatest number of relevant articles, while Richard S. Hotchkiss is the most frequently co-cited author. The research predominantly focuses on immunology, molecular biology, and clinical treatments. Keyword analysis suggests that immune cells, cell death, and personalized clinical treatments are emerging research hotspots in the field.
    Conclusion: This bibliometric analysis maps evolving trends and forecasts emerging hotspots in sepsis immunosuppression research, providing direction for future studies.
    Keywords:  bibliometric analysis; clinical treatment; immunoparalysis; immunosuppression; sepsis
    DOI:  https://doi.org/10.3389/fmed.2025.1615753
  23. Front Microbiol. 2025 ;16 1559926
    A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites.
    Shi-Ran Wang, Jie Zhou, Jia-Yi Zhang, Shi-Fang Li, Guo-Jie Hu.
       Background: Metabolites derived from the gut microbiota are substantial contributors to the pathophysiology of Irritable Bowel Syndrome (IBS). As our understanding of the mechanisms underlying gut microbiota metabolites advances, significant progress has been made in research exploring the correlation between gut microbiota metabolites and IBS. Nevertheless, a comprehensive synthesis of research foci and trends in this domain is still lacking. Consequently, integrating scientometric methods with a range of analytical tools can facilitate the identification of key research areas and potential future study directions.
    Methods: The present study employed scientometric tools, including VOSviewer, Bibliometrix software, CiteSpace, Tableau, and R software, to collect and analyze research literature on IBS and gut microbiota metabolites. This comprised an analysis of journal publications and their impact, the identification of prolific authors, the establishment of national research collaboration networks, and the co-occurrence analysis of keywords.
    Results: The analysis revealed that, following screening, a total of 1,489 documents were obtained, with a gradual increase in the number of publications starting from 2006. The United States, China, and the United Kingdom have been identified as the primary hubs of this research field. The leading research institutions were identified as University College Cork, the Mayo Clinic, and the University of California. In the domain of research under discussion, John F. Cryan, Timothy G. Dinan, and Gerard Clarke are the most prominent authors. Multiple analyses of the keywords revealed that research on gut microbiota metabolites in irritable bowel syndrome primarily focuses on the functions and mechanisms of action of specific metabolites (1). Emerging research hotspots on gut microbial metabolites influencing IBS are centered on bile acids. In contrast, chain fatty acids have been the most studied metabolites in past research. (2) Gut microbiota metabolites primarily affect IBS through the critical role of the gut-brain axis and are closely associated with anxiety-like behaviors. (3) Experimental types related to gut microbiota metabolites and IBS research.
    Conclusion: This study employed bibliometric analysis to map the knowledge structure and identify research hotspots in gut microbiota metabolites and IBS, providing insights for future studies.
    Keywords:  IBS; bibliometric analysis; gut microbiota; gut microbiota metabolites; research progress; research trend
    DOI:  https://doi.org/10.3389/fmicb.2025.1559926
  24. Proc (Bayl Univ Med Cent). 2025 ;38(5): 690-694
    A bibliometric analysis of general surgery residents entering into vascular surgery.
    Eric Chuang, Niteesh Sundaram, Praveen Satarasinghe, Ammar Humayun, Mark B Kahn, Sai Sajja.
       Introduction: Research productivity is an important component of the fellowship application for vascular surgery and is a criterion identified by program directors as important in the general surgery fellowship match. Bibliometric methods have been developed to standardize and quantify scholarly productivity. This study evaluated the research of general surgery residents who successfully matriculated into an independent vascular surgery fellowship.
    Methods: A list of the independent vascular surgery fellowships for the 2021-2022 academic year was first identified on the Society for Vascular Surgery website. Programs that displayed vascular fellows were selected for analysis. The names of all first- and second-year fellows were entered into Scopus, Google Scholar, and ResearchGate to obtain various bibliometric variables including number of total publications, number of vascular surgery publications, and number of citations upon matriculation into fellowship. Regression models were created to assess factors associated with publications.
    Results: Among independent vascular surgery fellowships, 83% were in academic training centers, 8% were in community training centers, and 9% were in university-affiliated training centers. Two-thirds of independent vascular surgery fellowship websites displayed fellow names; 17% of fellowships had one fellow, 49% had two fellows, 19% had three fellows, and 15% had four fellows (2.32 ± 0.93 fellows on average). The average number of publications upon matriculation for independent vascular fellows was 5, with an average of 3 publications within vascular surgery journals. On average, an incoming independent vascular fellow had 22 total citations. A larger number of fellows in the program (3 or 4) was observed to strongly correlate with publications (P < 0.01), number of vascular surgery publications (P < 0.01), and number of citations (P = 0.04). The geographic region of the fellowship did not correlate with research output. There was also no significant difference in research productivity among vascular surgery fellows coming from academic versus community versus affiliated general surgery residencies.
    Conclusion: Most independent vascular surgery fellowships are academic training centers with, on average, two fellows. Vascular surgery publications account for more than 50% of general surgery residents' research output upon vascular surgery fellowship matriculation. Larger independent vascular fellowships may attract candidates with greater scholarly productivity.
    Keywords:  Fellowship application; general surgery residency; research productivity; vascular surgery fellowship
    DOI:  https://doi.org/10.1080/08998280.2025.2525036
  25. F1000Res. 2025 ;14 489
    Trends in sleep dentistry research in Asia: A bibliometric analysis.
    Faizul Hasan, Mokh Sujarwadi, Lia Taurussia Yuliana, Ervina Restiwulan Winoto, An'nisaa Chusida, Hendrik Setia Budi.
       Background: Sleep-related conditions such as obstructive sleep apnea and bruxism significantly affect both oral and systemic health, posing substantial public health challenges. Growing scholarly interest in sleep dentistry reflects an emerging effort to address these conditions through multidisciplinary research. This study employs bibliometric analysis to examine emerging themes, collaborative patterns, influential authors, and research trajectories related to sleep dentistry in Asia.
    Methods: A comprehensive search was conducted using the Scopus database to identify relevant publications from inception through April 2025. Bibliometric techniques were applied to analyze co-authorship networks, annual publication trends, institutional and international collaborations, keyword co-occurrence, and citation metrics. VOSviewer and the Bibliometrix package in R were utilized for data visualization and network mapping.
    Results: The analysis included 1,237 publications. China was the leading contributor, followed by the United States and India. The United Kingdom exhibited the highest ratio of Multiple Country Publications, followed by Australia and Canada. Tehran University of Medical Sciences emerged as the most productive institution, followed by the All India Institute of Medical Sciences and Shahid Beheshti University of Medical Sciences. Co-authorship analysis revealed six distinct collaborative clusters, with a total of 5,828 scholars contributing to the field.
    Conclusion: A substantial and growing body of research on sleep dentistry has emerged in Asia. The bibliometric findings highlight influential contributors, international cooperation, and key research themes particularly obstructive sleep apnea and bruxism underscoring the value of bibliometric methods in shaping responses to this pressing regional public health concern.
    Keywords:  Collaborative Research; Health Equity in Asia; Human Wellbeing; Sleep Dentistry; Therapeutic Applications
    DOI:  https://doi.org/10.12688/f1000research.164414.1
  26. Ann Surg Oncol. 2025 Aug 18.
    Mapping Current Research Status and Emerging Frontiers of T-Cell Exhaustion: A Comprehensive Data-Mining-Based Study.
    Pengcheng Li, Qiang Guo, Yanfeng Gao, Wanqing Li, Haiyang Wu.
       BACKGROUND: T-cell exhaustion (Tex) represents a distinct immunological state characterized by the progressive functional deterioration of T cells under persistent antigenic stimulation. In recent years, the field of Tex research has attracted considerable attention, accompanied by a dramatic surge in related scientific literature. This study employed bibliometric methods to conduct a comprehensive analysis of Tex-related publications.
    METHODS: The scientific literature focusing on Tex published between 2005 and 2024 was retrieved from the Web of Science Core Collection. For comprehensive bibliometric evaluation, tools including CiteSpace, VOSviewer, and online websites were used to construct visual networks, including co-authorship, co-citation, and co-occurrence analysis. Quantitative assessment of research output and impact was performed through multiple metrics.
    RESULTS: The analysis included a total of 2831 publications. The data fitting analysis indicated an exponential growth in the number of publications per year. Regarding research contributions, the United States and China have consistently demonstrated their leading positions. Among academic institutions and individual researchers, Harvard University has emerged as the most productive organization. Reference analysis showed that chimeric antigen receptor (CAR) T-cell therapy is one of the fields that attract greatest attention in the current Tex research. Keyword analysis revealed that cancer was the most studied disease in this area, followed by hepatocellular carcinoma and HIV. Analysis of high-frequency keywords also found that current research focuses on the field centered around immunotherapy and immune checkpoint inhibitors, functional status of T cells and the mechanisms underlying Tex, tumor microenvironment, prognosis and biomarkers, and the role of Tex in specific diseases. In addition, in the coming years, several key areas will remain at the forefront of scientific exploration. These include machine learning, pan-cancer, programmed death-1 blockade, scRNA-seq, immune tolerance, VISTA, immunotherapy resistance, exosome, chronic inflammation, gene editing, triple-negative breast cancer, tumor microenvironment, solid tumors, multiple myeloma, and extracellular vesicles.
    CONCLUSIONS: This research represents the inaugural effort to perform an extensive bibliometric evaluation of literature focusing on Tex between 2005 and 2024. The findings derived from this analysis offer a credible resource for scholars aiming to swiftly grasp essential insights and emerging trends, as well as future hotspots within this domain.
    Keywords:  Bibliometrics; Data mining; Research hotspots; Research status; T-cell exhaustion
    DOI:  https://doi.org/10.1245/s10434-025-18066-2
  27. Medicine (Baltimore). 2025 Aug 15. 104(33): e43794
    Global trends in physical activity research of attention-deficit/hyperactivity disorder: A scientometric study (2000-2024).
    Dong Li, Chenmu Li, Jin Yan, Yang Li, Zexi Liu.
       BACKGROUND: Increasing evidence shows that physical activity interventions can improve attention-deficit/hyperactivity disorder (ADHD) symptoms. However, understanding of its etiology, treatment, and intervention remains limited. This study systematically analyzes literature from 2000 to 2004 to understand current knowledge, status, and predict future trends, aiming to offer clinicians and researchers a comprehensive perspective and reference for future studies.
    METHODS: A comprehensive literature search was conducted in the Web of Science Core Collection. Cite Space (version 6.1.R3) and visualization of similarities viewer (version 1.6.10) were employed for data visualization and analysis of publication outputs, collaborative networks, keyword co-occurrence, and co-citation patterns. This bibliometric review was conducted in accordance with the BIBLIO Checklist.
    RESULTS: Analysis of 569 articles shows an increasing trend in publications. The United States (279 articles), China (83 articles), and Germany (51 articles) lead in publication volume. Research is concentrated in universities, with Harvard Medical School (17 publications) at the forefront, followed by Natl Taiwan Normal University and University of Wisconsin (14 publications). Authors Chang, Yu-Kai, and Hung, Tsung-Min have the most publications (13 publications). The most cited reference is "DSM-5" with 94 citations. Keywords "ADHD" (172 times), "physical activity" (155 times), and "exercise" (94 times) are the most frequent.
    CONCLUSION: This study highlights the global rise in research on physical activity interventions for ADHD, with the United States leading in output and influence. Physical activity is emphasized as a promising complement or alternative to traditional treatments, offering potential benefits for ADHD symptom management. Key authors, institutions, and collaborations are identified, providing insights into research trends and hotspots. The findings serve as a valuable resource for advancing the understanding and practical application of physical activity interventions. Greater interdisciplinary and regional collaboration is essential for driving innovation and translating research into effective solutions for ADHD management.
    Keywords:  attention-deficit/hyperactivity disorder; bibliometrics; information visualization; physical activity; trends
    DOI:  https://doi.org/10.1097/MD.0000000000043794
  28. Cureus. 2025 Jul;17(7): e88114
    Global Research Trends in Artificial Intelligence and Type 2 Diabetes Mellitus: A Bibliometric Perspective.
    Paul Anthony Camacho López, Maria G Latorre-Arevalo, Pablo Camacho-Naranjo, Silvia J Villabona-Florez.
      Artificial intelligence (AI) applied to type 2 diabetes mellitus (T2DM) is transforming the diagnosis and management of this chronic disease, posing a significant public health challenge. Despite recent advances, there remains a gap in the systematization of knowledge regarding AI and T2DM, as well as in the identification of trends and scientific collaborations in this field. This study aims to conduct a comprehensive bibliometric analysis of academic output on AI applied to T2DM, mapping the main actors, collaboration networks, and predominant research themes from 2000 to 2024. A bibliometric analysis was conducted using the Web of Science database, focusing on scientific topics related to AI applied to T2DM from 2000 to 2024. Bibliometric tools such as Bibliometrix, VOSviewer, and CitNetExplorer were utilized to examine publication patterns, co-citation networks, and keywords. The analysis included 1,454 original articles and 134 reviews, aiming to identify the most influential authors, institutions, and countries in the field. The analysis revealed a growth rate of 1.7%, with significant increases observed between 2020 and 2024. The research highlighted the use of AI for the detection of diabetic retinopathy and continuous glucose monitoring as the primary areas of publication. China (27.4%) and India (20.5%) lead scientific production and international collaborations in this field, reflecting the globalization of health research. This study provides an overview of the current state and future opportunities in AI research applied to T2DM. The findings are valuable for researchers, healthcare professionals, and academic institutions, fostering progress in AI and T2DM through collaborative and ethical strategies. This bibliometric analysis contributes to guiding the development of health research policies and optimizing the use of AI in managing T2DM.
    Keywords:  artificial intelligence; bibliometrics; bibliometrix; citnetexplorer; machine learning; type 2 diabetes mellitus; vosviewer
    DOI:  https://doi.org/10.7759/cureus.88114
  29. Cureus. 2025 Jul;17(7): e88159
    Exploring the Relationship Between Fragile X Syndrome and Autism: A Bibliometric Analysis of Global Research Trends.
    Alyson Kaplan, Sofia Malik, Nadiya A Persaud, Latha Ganti.
      Fragile X syndrome (FXS) is classified as a genetic disorder located in the fragile X messenger ribonucleoprotein-1 (FMR1) gene on the X chromosome. FXS is considered the most prevalent single-gene cause of intellectual disability and autism spectrum disorder (ASD). Understanding the complexity of FXS and ASD requires exploring the correlation between genetics, neuroscience, and behavioral science. This bibliometric analysis explores the data from 3,398 articles collected from the Web of Science database, focusing on FXS and ASD while relating it to the country, institution, keywords, and published data for each article. These publications were imported into VOSviewer to analyze authorship patterns, associated organizations, involved countries, and keywords. The Web of Science database provided graphical figures illustrating the number of publications over the past 25 years and the most prominent funding agencies. Treatments for ASD and FXS often overlap due to their shared characteristics and connections; however, despite numerous clinical trials, no effective treatments have been identified for either condition to date. Although multiple drugs showed potential in preclinical trials, they failed to improve symptoms during the later stages of the trials. This study aims to identify key trends, gaps, and networks with regard to current FXS and ASD research, providing insights to inform future research and the development of effective treatment modalities.
    Keywords:  autism spectrum disorder (asd); bibliometric analysis; fragile x messenger ribonucleoprotein-1 (fmr1); fragile x syndrome (fxs); neurodevelopmental disorders
    DOI:  https://doi.org/10.7759/cureus.88159
  30. Technol Health Care. 2025 Aug 20. 9287329251362602
    Bibliometric analysis of research on artificial İntelligence applications in breast cancer diagnosis.
    Bengünur Ekinci, Hakan Tekedere.
      ObjectiveThis analysis aims to examine studies on artificial intelligence (AI) applications in breast cancer diagnosis through bibliometric methods, focusing on temporal and geographical trends. It contributes to shaping the field's roadmap and helping researchers adapt to technological innovations.MethodA comprehensive search was conducted in the Web of Science (WOS) database. Bibliometric analyses of data from 2013-2024 were performed using VOSviewer and Bibliometrix R programs.ResultsThe analysis included 1537 articles. A significant rise in research activity was observed in 2019. The thematic analysis highlighted topics like histopathology, feature selection, deep learning, and machine learning. India was the most productive country with 405 studies. Keyword analysis showed increased usage of terms like transfer learning, CNN, and radiomics. U.S. was the most cited country with 7511 citations. Concept co-occurrence analysis revealed strong associations between terms such as feature selection, datasets, algorithm performance, and classification methods. Bejnordi's 2017 study was identified as the most influential, with 1909 citations.Discussion and ConclusionThis study identifies key authors, influential works, and trending topics, offering a broad understanding of the field's structure and evolution. It helps outline the advancements and emerging directions in AI applications for breast cancer diagnosis.
    Keywords:  artifical intelligent; bibliometric analysis; breast cancer; data mining; deep learning; machine learning
    DOI:  https://doi.org/10.1177/09287329251362602
  31. J Alzheimers Dis Rep. 2025 Jan-Dec;9:9 25424823251367046
    Bibliometric analysis of pathological mechanisms in Alzheimer's disease: Applications based on mouse models.
    Jinjiang Li, Zhaoxiong Lin, Yufei Niu, Wenrui Chang, Siyun Song, Guang Yang, Feng Liu, Jiaxin Dai, Chunyan Hao.
       Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by memory loss and cognitive decline. Animal models play a key role in exploring its pathophysiological mechanisms.
    Objective: To analyze global research trends and knowledge structure in AD pathophysiological mechanisms based on animal models.
    Methods: Publications from 2014 to 2023 were retrieved from the Web of Science Core Collection. CiteSpace and VOSviewer were used for bibliometric analysis and data visualization.
    Results: A total of 2169 publications were identified, with a steady growth trend. The United States and China were the leading contributors, with Harvard University as a major collaborative hub. The Journal of Alzheimer's Disease published the most articles, while the Journal of Neuroscience had the highest co-citation frequency. Holtzman DM was a key author in the field. Nine keyword clusters were identified, including insulin resistance, amyloid beta, and oxidative stress. Emerging topics include synapse loss, gut microbiota, and NLRP3 inflammasome.
    Conclusions: This study provides a concise overview of global research on AD pathophysiological mechanisms in animal models, offering valuable insights for future research directions.
    Keywords:  Alzheimer's disease; animal model; bibliometrics; mice; pathology
    DOI:  https://doi.org/10.1177/25424823251367046
  32. Med Oral Patol Oral Cir Bucal. 2025 Aug 16. pii: 27516. [Epub ahead of print]
    Quality of life after third molar surgery: a bibliometric analysis of randomized clinical trials.
    E-F Maferano, J-L Júnior, T-R Ribeiro, P-R Martins-Filho, P-G Silva, A-F Granville-Garcia, F-W Costa.
       BACKGROUND: This study aimed to conduct a bibliometric analysis of randomized controlled trials (RCTs) that evaluated quality of life following third molar surgery.
    MATERIAL AND METHODS: A bibliometric analysis was performed in accordance with the BIBLIO checklist across 11 databases: Web of Science, MEDLINE, EMBASE, CINAHL, PsycINFO, The Cochrane Library, Livivo, LILACS, Scopus, Epistemonikos, and Google Scholar. RCTs that assessed quality of life after third molar surgery were included. Searches were conducted on September 20, 2024, and updated on May 5, 2025.
    RESULTS: The initial search retrieved 4,217 records, of which 46 articles were included. The average annual number of publications between 2008 and 2024 was 2.7. A total of 192 authors contributed to the included studies, with the University of Mosul being the most productive institution. India and Iraq were the most prolific countries, each contributing five publications. Most articles were published in journals specializing in oral and maxillofacial surgery. The terms extracted from the titles co-occurrence analysis revealed distinct thematic clusters.
    CONCLUSIONS: Scientific output on quality of life following third molar surgery has shown consistent growth. Future RCTs are encouraged to incorporate qualitative approaches to gain a broader understanding of the clinical and social impacts of surgical interventions.
    DOI:  https://doi.org/10.4317/medoral.27516
  33. Front Plant Sci. 2025 ;16 1616642
    Trends in research on relationship between root exudates and soil phosphorus: a bibliometric analysis.
    Yijie Ding, Jiabao Yao, Fengqing Li, Shiyou Chen, Hui Wang, Lingyu Hou, Lei Liu, Qiwu Sun.
       Introduction: Phosphorus (P) is an essential element for plant growth, but low availability of soil phosphorus limits agricultural and forestry development. Root exudates play a significant role in enhancing soil phosphorus availability.
    Methods: Based on bibliometric methods, this study conducted a quantitative analysis of 276 relevant articles from the Web of Science database between 2001 and 2024 using visualization tools such as CiteSpace and VOSviewer. The analysis explored multiple dimensions, including publication volume, contributing countries, highly cited literature, and keyword trends.
    Results: The results revealed that research in this field has gradually gained attention over the past two decades, with a rising trend in publications, particularly dominated by China. Studies primarily focused on botany, soil science, and agronomy, with frequent publications in journals such as Plant and Soil. Through clustering of high-frequency keywords related to root exudates and soil phosphorus interactions, research hotspots were found to have expanded from model plants and plant growth traits to diverse plant species and deeper mechanistic explorations.
    Conclusion: Future research should emphasize international collaboration, integrate controlled laboratory experiments with field trials, and leverage multidisciplinary approaches to advance practical applications, providing insights for addressing potential soil phosphorus crises and providing scientific support for the sustainable development of global agriculture and forestry and carbon neutrality goals.
    Keywords:  CiteSpace; available nutrients; bibliometrics analysis; phosphorus; root exudates
    DOI:  https://doi.org/10.3389/fpls.2025.1616642
  34. Health Educ Behav. 2025 Aug 17. 10901981251361958
    Mobile Interventions for Reducing Sedentary Behavior and Promoting Physical Activity Among Office Workers: Bibliometric Study.
    Baskaran Chandrasekaran, Chythra R Rao.
      Mobile technologies have become key tools to promote physical activity and reduce sedentary behavior among office workers. While workplaces serve as ideal settings for implementing such interventions, bibliometric analyses of the growing literature evaluating their effectiveness remain limited. The aim of this bibliometric analysis was to examine trends in research productivity and impact of m-health within workplace-related literature. Six databases including Web of Science, Scopus, Ovid Medline, Cochrane Central, Cumulative Index of Nursing and Allied Health Library, and Embase were searched for the studies that have explored the m-health interventions to promote physical activity and reduce sedentary behavior among office workers on February 12, 2024. The studies were downloaded as BibTex files and analyzed for productivity, citation impact, and intellectual structure (conceptual and social structural) using Biblioshiny, Bibliometrix software. In total, 113 studies were identified with 10% of studies published in JMIR mHealth and uHealth and BMC Public Health. Mair JL, 2022 was found to be a significant contributor to the evidence. Australia, the United Kingdom, and the United States continue to dominate the contributions. M-health, obesity, physical activity, and validity were among the most frequently used terms, whereas digital health, development, and adherence remain underrepresented in the literature. Research on m-health to promote physical activity and reduce sedentary behavior among office workers is growing, predominantly in high-income countries. However, interdisciplinary collaboration and studies integrating behavioral science, primary care, digital development, and end-user acceptability remain limited and are urgently needed.
    Keywords:  bibliometrics; m-health; office workers; physical activity; sedentary behavior
    DOI:  https://doi.org/10.1177/10901981251361958
  35. Biomed Eng Comput Biol. 2025 ;16 11795972241271549
    Exploring the Landscape of Operating Room Scheduling: A Bibliometric Analysis of Recent Advancements and Future Prospects.
    Md Al Amin, Majed Hadid, Adel Elomri, Rabah Ismaen, Ismail Dergaa, Hind Alashi, Amal Jobran Al-Hajaji, Moustafa Alkhalil, Omar M Aboumarzouk, Abdelfatteh El Omri.
       Background: Operating Room Scheduling (ORS) is vital in healthcare management, impacting patient outcomes, economics, and the shift to value-based care. The academic literature offers various solutions with distinct pros and cons.
    Aim: This study aims to (i) outline ORS challenges across surgical specialties; (ii) examine ORS's impact on healthcare goals, focusing on patient outcomes, value-based care, and economics; (iii) assess academic solutions' real-world applicability; and (iv) conduct a bibliometric analysis to track ORS research progression, pivotal works, and future directions.
    Methods: We performed a comprehensive bibliometric analysis using Scopus data. Biblioshiny from Bibliometrix aided data mining and analysis, spanning 2000 to 2023, tracking publication trends, themes, co-occurrence, and co-citation networks.
    Results: ORS publications steadily rose, notably post-2013, led by developed nations like the UK, Australia, the US, France, and Germany. Key themes included operating rooms, surgery, and humans. Seven primary research routes emerged, covering Surgery Duration, Allocation, Advanced Scheduling Integration, and Patient Flow Optimization. Citation analysis highlighted heuristic algorithms and integer programing as central ORS themes.
    Conclusion: This study offers a panoramic ORS overview, advocating an integrated approach aligning patient outcomes, economics, and value-based care. Bibliometric analysis charts ORS research evolution guides future research, and holds significance for practitioners, policymakers, and academics, enhancing ORS paradigms and healthcare delivery.
    Keywords:  Healthcare management; optimization; patient outcomes; resource allocation; surgical procedures; value-based care; workflow efficiency
    DOI:  https://doi.org/10.1177/11795972241271549
  36. Hereditas. 2025 Aug 16. 162(1): 164
    Global trends in machine learning applications for single-cell transcriptomics research.
    Xinyu Liu, Zhen Zhang, Chao Tan, Yinquan Ai, Hao Liu, Yuan Li, Jin Yang, Yongyan Song.
       BACKGROUND: Single-cell RNA sequencing (scRNA-seq) has revolutionized cellular heterogeneity analysis by decoding gene expression profiles at individual cell level, while machine learning (ML) has emerged as core computational tool for clustering analysis, dimensionality reduction modeling and developmental trajectory inference in single-cell transcriptomics(SCT). Although 3,307 papers have been published in past two decades, there remains lack of bibliometric review comprehensively addressing methodological evolution, technical challenges and clinical translation pathways. This study aims to fill research gap through bibliometric and visual analysis, revealing technological evolution trends and future development directions.
    METHODS: Using 3,307 publications from Web of Science Core Collection(WOSCC), we conducted bibliometric and visualization analysis through CiteSpace and VOSviewer to systematically review research trends, national/institutional contributions, keyword co-occurrence networks and co-citation relationships. Data screening strictly limited to English articles and reviews, excluding irrelevant document types, focusing on core application scenarios of ML in SCT.
    RESULTS: China and United States dominated research output (combined 65%), with China leading in publication volume (54.8%) while US demonstrating academic influence through H-index 84 and 37,135 total citations. Research hotspots concentrated on random forest (RF) and deep learning models, showing transition from algorithm development to clinical applications (e.g., tumor immune microenvironment analysis). Chinese Academy of Sciences and Harvard University emerged as core collaboration hubs, with international cooperation network primarily featuring US-China collaboration. Keyword clustering revealed four themes: gene expression, immunotherapy, bioinformatics, and inflammation-related research. Technical bottlenecks included data heterogeneity, insufficient model interpretability and weak cross-dataset generalization capability.
    CONCLUSION: ML-scRNA-seq integration has advanced cellular heterogeneity analysis and precision medicine development. Future directions should optimize deep learning architectures, enhance model generalization capabilities, and promote technical translation through multi-omics and clinical data integration. Interdisciplinary collaboration represents key to overcoming current limitations (e.g., data standardization, algorithm interpretability), ultimately realizing deep integration between single-cell technologies and precision medicine.
    Keywords:  Bibliometric analysis; Deep learning; Machine learning; Random forest; Single-cell transcriptomics
    DOI:  https://doi.org/10.1186/s41065-025-00528-y
  37. J Health Popul Nutr. 2025 Aug 18. 44(1): 297
    Evolving landscape of hepatitis C research in the Eastern Mediterranean Region: A comprehensive bibliometric analysis from 2004 to 2024.
    Kamiar Izadpanah, Seyed Aria Nejadghaderi, Hamid Sharifi.
       BACKGROUND: Hepatitis C presents a significant public health challenge in the Eastern Mediterranean Region (EMR), which has the highest global disease burden. This study aims to provide a comprehensive overview of Hepatitis C-related research in the EMR using bibliometric analysis.
    METHODS: Between January 1, 2004, and December 31, 2024, a bibliometric search was conducted using the Scopus database to identify Hepatitis C-related publications from countries in the EMR. The analysis was performed using the R-based Bibliometrix tool, which examined research productivity trends, recent themes, thematic evolution, and co-occurrence networks of terms.
    RESULTS: The analysis identified 9,357 publications with an 8.06% annual growth rate and 170,021 total citations. Two distinct research clusters emerged: treatment regimens and epidemiological studies. Thematic evolution revealed a consistent focus on cirrhosis and hepatocellular carcinoma, while treatment approaches shifted from interferon-based therapies to direct-acting antivirals. Analysis of genotype-related research highlighted the regional importance of Genotype 4. Recent trends indicated integrating Hepatitis C research with broader public health concerns like COVID-19.
    CONCLUSIONS: The Hepatitis C research landscape in the EMR is dynamic and maturing, characterized by substantial growth, diversification of research themes, and adoption of advanced treatment strategies. The findings underscore the need for continued multidisciplinary efforts and a focus on emerging themes to advance Hepatitis C management further and improve regional patient outcomes.
    Keywords:  Bibliometric analysis; Eastern Mediterranean Region; Hepatitis C; Liver cirrhosis; Liver neoplasms; Public health
    DOI:  https://doi.org/10.1186/s41043-025-01044-5
  38. Discov Oncol. 2025 Aug 17. 16(1): 1569
    Bibliometric analysis of immunogenic cell death in hepatocellular carcinoma.
    Jianming Sun, Chun Liu, Dongdong Liu, Xinlian Hu, Shirong Ren, Guoying Jiang, Daizhong Zhang, Shuai Hu, Xiaojing Yuan, Jun Tao.
       OBJECTIVES: This study aimed to delineate global research trends in immunogenic cell death (ICD) within hepatocellular carcinoma (HCC) by mapping collaborative networks, thematic shifts, and high-impact findings. Using VOSviewer network visualisation and R-bibliometrix quantitative metrics, we sought to show how scientific output has evolved and to pinpoint research gaps that may guide future investigations.
    METHODS: We retrieved 568 publications from the Web of Science Core Collection (2000-2024) using a tailored keyword strategy encompassing "Hepatocellular carcinoma" and "Immunogenic cell death." Data were analyzed with VOSviewer and R-bibliometrix to visualize co-authorship patterns, keyword clusters, institutional collaborations, and citation metrics.
    RESULTS: Annual publication volumes rose markedly, peaking at 68 in 2023, and this quantitative surge parallels a qualitative shift toward clinically actionable research outputs. Over the entire period, the corpus accumulated 13 161 citations (mean 23.2 citations/article), indicating strong and growing academic influence. Keyword co-occurrence revealed three main clusters highlighting immunotherapeutic mechanisms, molecular pathways (e.g., HMGB1 and calreticulin), and epidemiological concerns. China and the United States led in overall output, with universities such as the University of California System, Harvard University, and Shanghai-based institutions forming robust collaborative networks. Highly cited articles, such as Zhong et al. (2016, Cell) on autophagy-inflammation crosstalk and Yu et al. (2020, ACS Nano) on mitophagy-augmented doxorubicin, underscored the role of autophagy, checkpoint inhibitors, and combination therapies in harnessing ICD to overcome HCC's immunosuppressive microenvironment. These patterns indicate that the field is transitioning from descriptive bibliometrics to translational studies, signalling that forthcoming work will likely accelerate rational design of ICD-based clinical trials and inform funding priorities.
    CONCLUSION: The findings confirm ICD as an emerging cornerstone of HCC research, with demonstrated capacity to reshape clinical-trial portfolios and refine biomarker-driven patient stratification, reflecting both deeper mechanistic insights and accelerating translational efforts. Ongoing challenges include refining biomarkers, integrating ICD inducers with immunotherapies, and accounting for HCC's inherent complexities such as chronic liver disease and metabolic dysfunction. Future research directions focus on the use of nanotechnology for precise drug delivery, the integration of metabolomics and genomics data to enable personalised treatment, and the improvement of combination therapies combined with local interventions.
    Keywords:  Calreticulin exposure; Checkpoint inhibitors; Combination therapy; Hepatocellular carcinoma; Immunogenic cell death
    DOI:  https://doi.org/10.1007/s12672-025-03362-w
  39. Germs. 2025 Mar;15(1): 11-25
    Bibliometric analysis of highly pathogenic avian influenza research globally from 2003 to 2023.
    Clement Meseko, Uwem Okon Edet, Okoroiwu Henshaw, Nicodemus Mkpuma, Kayode Abraham Olawuyi, Charles Archibong.
       Introduction: Despite decades of research on highly pathogenic avian influenza, especially H5N1, an understanding of the impact of research outputs on policy, the impact of funding and policies, collaboration between authors, and other bibliometric measurable indices is elusive.
    Methods: H5N1 research data were retrieved from the PubMed database using "H5N1", "highly pathogenic", and "influenza" as keywords, and combined with the Boolean operator, "OR". The evaluated growth pattern of H5N1 research was analysed using Microsoft Excel, while the VOS viewer window version 1.6.15 was utilized in analyzing the keywords, authors' inputs, and collaborations amongst research institutes/universities involved in H5N1 research.
    Results: A total of 8,411 articles published within 2003 and 2023 were retrieved. The trend of the published articles indicates that 2003 to 2004 had the lowest number of articles, while the highest were observed for 2009 and 2010. Since then, there has been a gradual decline. The most dominant article type was original research article (89.80%), followed by reviews with 7.54%. The most productive countries were Japan, the United States of America, China, and Egypt in Africa. The top 15 authors accounted for 12.40% of the total published data. Keywords analysis revealed the emergence of newer keywords such as H5N8, wild birds, mammals, and Nigeria; however, as expected, influenza virus avian H5N1 subtype was the dominant keyword. Research institutes with backgrounds in agriculture and veterinary medicine dominated the top 15 organizations involved in H5N1 research.
    Conclusions: Our findings suggest that research aimed at developing therapeutics and vaccines, as well as continuous surveillance in high-risk areas is urgently needed. Furthermore, the findings provide baseline data for all the stakeholders involved in H5N1 research, which could inform future research, funding, and policies.
    Keywords:  H5N1; evolution; highly pathogenic avian influenza; policies; research output
    DOI:  https://doi.org/10.18683/germs.2025.1451
  40. Adv Med Educ Pract. 2025 ;16 1421-1438
    Mapping Key Nodes and Global Trends in AI and Large Language Models for Medical Education: A Bibliometric Study.
    Kaining Lu, Shuben Sun, Wanzhang Liu, Junhui Jiang, Zejun Yan.
       Background: Artificial intelligence (AI) and large language models (LLMs) are transforming medical education by enhancing teaching and assessment methods. Research output has surged, but key bibliometric trends remain underexplored.
    Methods: We retrieved 547 publications using the Web of Science Core Collection and conducted bibliometric analysis with CiteSpace and other bibliometric tools to examine publication volume, collaboration networks, citations, keywords, and other important bibliometric indicators.
    Results: The United States, the United Kingdom and China lead publication output, with institutions like the University of London, the National University of Singapore and Harvard University at the forefront. JMIR Medical Education is a pivotal journal. Research on ChatGPT and LLMs dominates, with growing focus on nursing education, digital health, medical exams, and medical ethics. Clinical reasoning, undergraduate education, and virtual reality have been identified as underexplored areas of research.
    Conclusion: AI and LLMs in medical education constitute a fast-evolving field, with journal calls shaping its bibliometric landscape and advancing the discipline. The field remains in a developmental phase, with subfields yet to be clearly defined. Topics such as nursing education, digital health, medical examinations, and conversational agents are gaining traction. Research on ChatGPT and LLMs holds a central and influential role. Emerging areas of focus include medical ethics, training methodologies, and skills development. Clinical reasoning, undergraduate education, and virtual reality in AI and LLMs for medical education are understudied, offering research opportunities.
    Keywords:  ChatGPT; artificial intelligence; bibliometric analysis; large language model; medical education
    DOI:  https://doi.org/10.2147/AMEP.S538362
  41. Dermatol Reports. 2025 Aug 18.
    A bibliometric study of the top 100 most cited articles on melanoma: insights into research trends and characteristics.
    Jinhao Zhang, Xiangze Meng, Yun Wang, Wei Liu.
      Improving insights into the current research and literature on melanoma is useful for healthcare providers to apply the latest advancements for offering better care to patients. Herein, this bibliometric study analyzed the characteristics and trends in melanoma research through the top-cited articles. The top 100 most cited articles on melanoma were published between 1969 and 2020, and the average number of citations was 36.8-893.9 (mean 176.8). Notably, the frequencies of the main key words, including antineoplastic agents, genetics, randomized controlled trials, metastatic melanoma, BRAF, and monoclonal antibodies, during 2010-2020 were significantly higher than those during 1969-2009. Specifically, the main study topics after 2010 were drug research aspects, such as drug safety, drug efficacy, drug resistance, drug withdrawal, cytotoxic T lymphocyte-associated protein 4 (CTLA-4), programmed cell death 1/programmed death-ligand 1 (PD-1/PD-L1), ipilimumab, nivolumab, trametinib, dabrafenib, vemurafenib, and various drug adverse effects. The emergence of immunotherapy caused a burst of citations and substantially changed the distribution of the top-cited articles.
    DOI:  https://doi.org/10.4081/dr.2025.10435
  42. J Am Acad Orthop Surg Glob Res Rev. 2025 Aug 01. 9(8):
    An Assessment of the Journal of Bone and Joint Surgery Publication Trends From 2012 Through 2022.
    Kira L Smith, Monish S Lavu, Molly M Piper, Bhargavi Maheshwer, Kallie J Chen, Robert J Gillespie, Raymond E Chen.
       BACKGROUND: Clinical research is an integral component of orthopaedic practice with the purpose of advancing the field and improving patient care. The Journal of Bone and Joint Surgery (JBJS) is a well-respected journal with a high impact factor and considerable influence on clinical practice. To our knowledge, there has been no systematic evaluation highlighting the variety of research published in this journal. Therefore, the purpose of this study was to evaluate trends in characteristics of articles published in JBJS from 2012 to 2022, including type of study, level of evidence, author information, and country of publication.
    METHODS: Articles published in JBJS between 2012 and 2022 were retrieved from the JBJS Archives. Title, level of evidence, description of the study as delineated in the abstract, first author degree, number of authors, and country of publication were recorded for each published article.
    RESULTS: A total of 2668 articles were published in JBJS from 2012 to 2022. The proportion of preclinical studies published per year significantly decreased (P = 0.0025), whereas no statistically significant change was observed in the proportion of clinical studies (P = 0.34). A significant increase was noted in the proportion of database studies published (P = 0.00012). Studies classified as level II decreased over the study period (P = 0.029), whereas level III increased over the study period (P = 0.034). The average number of authors per article was 6 ± 3 authors with a significantly increasing trend over the study period (P = 0.0043). The proportion of first authors who were MD or equivalent decreased (P = 0.025), whereas first authors who were non-MD or non-PhD equivalent increased (P = 0.0068).
    CONCLUSION: The publication trends in JBJS over the past decade demonstrate the changing landscape of orthopaedic research as it aims to address the burden of musculoskeletal injury and disease.
    DOI:  https://doi.org/e25.00002
  43. J Pediatr Orthop. 2025 Aug 18.
    Prevalence and Success of Pediatric Orthopaedic Trainee Research Grants.
    Andy M Liu, Mackenzie Bird, Adeesya Gausper, Nora Galoustian, Suhas Etigunta, Vivien Chan, Amelia Lindgren, David Skaggs, Kenneth Illingworth.
       BACKGROUND: In this study, we evaluate the frequency of trainee grants awarded to pediatric orthopaedic topics, their subsequent publication success, and the recipients' career trajectories post-training.
    METHODS: Research grants awarded by SRS (2020-2024), OREF (2012-2022), AONA (2000-2021), OTA (2012-2022), and POSNA (2014-2024) were obtained from their respective organizations. Only projects awarded to trainees (residents/fellows) and specific to pediatric orthopaedic topics were included. Projects were characterized by study type: (1) basic science, (2) biomechanical, (3) clinical, and (4) other. Univariable analysis was performed to determine the impact of the category of grant and grant amount on subsequent publication. Recipients were also evaluated on post-residency career trajectories, including academic position and specialization in pediatrics orthopaedics.
    RESULTS: A total of 1015 grants were analyzed, with a total of 55 (5%) that were awarded to trainees. Of these grants, 13% were basic science, 20% were biomechanical, 45% were clinical-based, and 22% were other types. At the time of data collection, 58% (n=32) were published. Project type was not associated with publication success. Of the 35 recipients who finished training at the time of analysis, 80% (n=28) of recipients held an academic position and 63% (n=22) had completed a pediatric orthopaedic fellowship.
    CONCLUSIONS: Pediatric-specific trainee grants are associated with high publication rates. The majority of grant recipients pursue pediatric orthopaedic fellowships and continue in academic medicine. Compared with trauma resident research grants, pediatric grants are less available (397 vs. 55); however, recipients of pediatric grants are more likely to publish their grant (58% vs. 38%) and obtain academic positions following training (80% vs. 45%).
    LEVEL OF EVIDENCE: Level III.
    Keywords:  AONA; POSNA; SRS; academic; fellow; fellowship; grant; orthopaedics; pediatric; publication; research; resident; success
    DOI:  https://doi.org/10.1097/BPO.0000000000003083
  44. Brain Spine. 2025 ;5 104242
    From abstracts to published articles: Assessing the scientific publications from the annual meetings of the German Spine Society (DWG) in 2017, 2018, 2019, and 2022.
    Spine Science Commission of the German Spine Society (DWG)
       Introduction: The annual meeting of the German Spine Society (DWG) serves as a platform for discussing the latest academic findings. This study assessed the scientific quality of these conferences by investigating the publication rate of abstracts presented at DWG Annual Meetings (2017-2019, 2022) in peer-reviewed journals and analyzing factors influencing publication rates.
    Research question: How did the publication rates of the annual meeting of the DWG evolve, and what factors influenced them.
    Material & methods: We reviewed all accepted oral and poster presentations and conducted a PubMed database search (up to 10/2023) to determine publication rates, time to publication, research type, and topic distribution.
    Results: A total of 730 abstracts were presented, with 275 (37.6 %) published in peer-reviewed journals: 27.9 % (2017), 52.7 % (2018), 39.1 % (2019), and 29.9 % (2022). A subset of 61 (8.4 %) abstracts had already been published before the conference. The mean time to publication was 35.4 ± 22.3 months. Basic research and experimental studies constituted 22.1 % of abstracts, achieving a 44.1 % publication rate. Key research fields included spinal cord injury (16.9 %), biomechanics (14.8 %), spinal oncology (8.8 %), and bone and cartilage (4.4 %), while 55.1 % covered other spinal surgery topics.
    Discussion & conclusions: With 37.6 % of abstracts published in PubMed-indexed journals, our findings highlight the scholarly impact of DWG meetings. These results reflect the scientific quality of submissions and provide insights for future improvements to enhance the DWG's research focus.
    Keywords:  Publication rate; Research; Scientific congress; Spine
    DOI:  https://doi.org/10.1016/j.bas.2025.104242
  45. PLOS Glob Public Health. 2025 ;5(8): e0005066
    Towards inclusive authorship: Analyzing author representation in PLOS Global Public Health front matter content.
    Esme Supriya Gupta Longley, Shashika Bandara.
      Underrepresentation and lack of inclusion of Global South researchers have been key shortcomings in global health publications. This has contributed to epistemic injustice in global health and impacted evidence informed policymaking. PLOS Global Public Health (GPH)was launched in 2021 with the goal of charting a new path towards equity, diversity and inclusion in global health publications. The journal also invited independent assessments of its progress. This study analyses commissioned 136 front matter content (opinions, reviews, and essays) and a total of 878 authors published in PLOS GPH between October 2021 and December 2024. Using publicly available data from the journal website and online profiles, we examined authorship representation based on World Bank country income classification, gender, and Indigeneity. Additionally, we examined article content in terms of country focus and topics covered. We inferred gender by reviewing public profiles for gendered prefixes and pronouns and when unavailable by using genderize.io. We analyzed for Indigeneity by reviewing authors' public profiles. Our results indicate that 609 of 878 (69%) of authors for the commissioned content were affiliated with high income countries. Under gender representation, 403 of 878 (46%) authors identified as women compared to 471 of 878 (54%) as men. Only 7 of 135 (5%) first authors and 6 of 117 (5%) senior authors publicly identified as Indigenous. While most articles had a global focus (78 of 136, or 57%), 46 of 136 (34%) focused on the Global South, and 12 of 136 (8%) on the Global North. Global South affiliated authors were better represented in articles pertaining to the Global South, comprising on average 43% of authorship compared to an overall average of 30%. To advance equity, journals should commission more content from Global South authors and actively invite contributions from Indigenous and gender-diverse authors on topics relevant to their communities.
    DOI:  https://doi.org/10.1371/journal.pgph.0005066
  46. Med Gas Res. 2026 Jun 01. 16(2): 161-168
    Molecular hydrogen and kidney diseases: a scoping review based on scientometry and data analytics.
    Johanna Viana, Cecilia Castro, Víctor Leiva.
      Acute kidney injury and chronic kidney disease impose substantial burdens on healthcare systems worldwide. Molecular hydrogen (H2) has emerged as a potential therapy due to its selective antioxidant, anti-inflammatory, and antiapoptotic properties. The present study reviews evidence on H₂-based renal interventions, examining therapeutic mechanisms, bibliometric trends, and existing research gaps based on data analytics. This scoping review integrates quantitative bibliometric analysis with qualitative thematic synthesis. This integration, uncommon in conventional scoping reviews, reveals important gaps. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines, 69 publications were identified through Scopus and Web of Science. These publications mostly originated from Asia, particularly China and Japan, with clear peaks of activity in 2019 and 2024, but international collaboration remains limited. H₂ consistently demonstrated protective effects against apoptosis, fibrosis, inflammation, and oxidative stress across acute kidney injury, nephrotoxicity, transplantation, and early chronic kidney disease models. Our findings suggest that hydrogen therapy holds promise for renoprotection in both acute kidney injury and chronic kidney disease. Nonetheless, more robust clinical trials and standardized research methodologies are imperative to facilitate its broader adoption into clinical nephrology practice.
    Keywords:  PRISMA; Scopus database; Web of Science database; acute kidney injury; bibliometric analysis; chronic kidney disease; hydrogen-rich saline; hydrogen-rich water; inflammation; nephrotoxicity; renal protection
    DOI:  https://doi.org/10.4103/mgr.MEDGASRES-D-25-00047
  47. BMC Med Educ. 2025 Aug 19. 25(1): 1178
    Association of completing an intercalated year-long research degree with post-graduation academic success.
    Ibrahim S Al-Busaidi, William Ju, Yassar Alamri, Tim J Wilkinson.
       BACKGROUND: There is a paucity of data regarding the long-term outcomes of research intercalation during under-graduate medical studies, and the long-term academic effects it can have for such students. This study aimed to investigate the associations with longer-term academic success for students who undertook a BMedSc(Hons) degree intercalated within a medical degree.
    METHODS: The study used a matched cohort design. Cases were medical students who completed a BMedSc(Hons) degree at our institution between 1995 and 2006; controls were matched for gender and graduation year. Our primary outcome was the association of completing a BMedSc(Hons) with three academic success variables: quantity of post-graduation peer-reviewed publications, completion of higher academic degrees, and attainment of faculty/academic positions post-graduation.
    RESULTS: We found that students completing a BMedSc(Hons) were more than seven times as likely to have at least one peer-reviewed journal publication post-graduation compared with matched controls (77.7% vs. 37.2%, OR 7.3 (CI: 3.13-13.17.21), P < 0.001). They were also more likely to have a greater number of publications (n = 577 vs. n = 140), more likely to complete a higher academic degree (18.1% vs. 6.4%, OR 3.2 (CI: 1.17-8.74), P = 0.023) including a PhD (13.8% vs. 1.1%, OR 13.0 (CI: 1.70-99.38), P = 0.013), but they were not significantly more likely to attain a faculty position (17% vs. 11.7%, OR 1.6 (CI: 0.67-3.59), P = 0.301).
    CONCLUSION: Medical students completing a research degree go on to have successful academic careers. We hypothesize that building research networks early in a student's career is associated with their ability to participate in research in the future, although attaining faculty/academic positions may be influenced by other factors.
    Keywords:  Clinical academic training; Early research exposure; Intercalated degree; Medical education; Medical school; Medical student research; Publishing; Research
    DOI:  https://doi.org/10.1186/s12909-025-07133-7
  48. Neurosci Biobehav Rev. 2025 Aug 16. pii: S0149-7634(25)00343-4. [Epub ahead of print]177 106342
    Systematic mapping and bibliometric analysis of meta-analyses on animal cognition.
    Ayumi Mizuno, Malgorzata Lagisz, Pietro Pollo, Lauren Guillette, Masayo Soma, Shinichi Nakagawa.
      Meta-analyses play an important role in empirically synthesising research and guiding future directions. The field of animal cognition is rapidly expanding, with both empirical and review papers increasing at a faster rate than those in the life sciences overall. However, the use of meta-analyses, their methodological rigour, and the geographic distribution of research activity remain unclear. We systematically reviewed 49 meta-analytical studies encompassing 1824 primary studies on animal cognition. Half of the meta-analytical studies focused on the evolution and diversity of non-human animal cognition, while the other half used animals as models to understand human cognition. Most studies addressed factors affecting cognitive abilities, focusing on mammals and birds. Although many studies aimed to examine evolutionary or diversity-related questions, few analysed cognitive variation across species or tested evolutionary hypotheses, and even fewer incorporated phylogenetic relationships. While some studies investigated sex differences, many reported that they could not due to unbalanced sex ratios in the primary studies, notably a predominance of males. Both primary and meta-analytical studies often lacked adequate methodological reporting and rarely shared raw data or analysis scripts. Our bibliometric analysis showed that research is geographically concentrated, with authorship and collaboration mostly in high-income countries. To address current gaps, we recommend greater adherence to open science practices, improved regional inclusivity, and broader taxonomic and individual-level coverage. Finally, we highlight the complementary roles of meta-analyses and Big Team Science in advancing the field by improving its transparency, inclusivity, and reliability.
    Keywords:  Comparative psychology; Geographic bias; Open science; Reporting quality; Reproducibility; Research synthesis; Scientific inequality
    DOI:  https://doi.org/10.1016/j.neubiorev.2025.106342
  49. Fed Pract. 2025 Apr;42(4): 162-165
    Scholarly Activity Among VA Podiatrists: A Cross-Sectional Study.
    Dominick J Casciato.
       Background: US Department of Veterans Affairs (VA) podiatrists advance clinical practices and ensure expert foot and ankle care for veterans. Quantifying the research expertise of VA podiatrists will enhance the confidence of the veteran population regarding the care they receive from highly knowledgeable and research-active clinicians, and provide podiatrists insight into their professional development.
    Methods: This cross-sectional analysis aimed to describe the expertise of VA podiatrists; those with a history of peer-reviewed publications were analyzed. Sex, region of practice, salary, academic appointment, number of publications, and h-index were recorded. Descriptive statistics were reported, and associations between variables were assessed. The threshold for statistical significance was set at P ≤ .05.
    Results: Of 819 podiatrists, 157 met the selection criteria for final analysis, with most being male and located primarily on the West Coast. Significant differences were found in the median number of publications and the Hirsch index among academic ranks, but no relationship was observed between salary and these metrics. No statistically significant difference was noted in average salary among different academic appointments, although compensation did vary.
    Conclusions: A substantial proportion of VA podiatrists have published their research, providing advanced foot and ankle care to veterans. These findings underscore the expertise available to veterans and highlight its role in enhancing clinical practices and professional growth among VA podiatrists.
    DOI:  https://doi.org/10.12788/fp.0574
  50. Sci Rep. 2025 Aug 17. 15(1): 30083
    Analysis of collaborative robot technology patent map and research on development trends.
    Di Zhang, Lihua Liu.
      This study conducts a systematic analysis of global patents in the field of collaborative robot technology based on applications and type of industry. The data analyzed derives from the PatSnap database covering 30,425 patents from 2006 to 2025, using explicit keywords such as "collaborative robot" to ensure specificity, with procedural filters and manual curation applied to maximize relevance and accuracy. The research focuses on patent application trends, technological hotspots, geographical distribution, as well as applicant and inventor analyses, providing a comprehensive overview of the innovation landscape and development trends in this domain. The findings indicate that collaborative robot technology has undergone three distinct phases: the initial emergence period, a phase of rapid growth, and a subsequent slowdown, and it is now transitioning into a stage of mature development. This apparent recent slowdown is significantly influenced by the standard 18-month lag in patent publication, meaning current data for the latest years is incomplete. Invention patents dominate the field, reflecting a high level of technological innovation. From a geographical perspective, the United States and China serve as the primary global innovation hubs, with their patent application volumes significantly surpassing those of other countries. In terms of applicants, multinational corporations such as Qualcomm, Intel, BRIGHT DATA LTD, and NVIDIA lead in patent filings, while emerging enterprises have demonstrated notable growth in patent applications, injecting new vitality into the industry. Furthermore, through patent citation analysis and market value assessment, this study identifies high-value patents and key technological areas, offering valuable insights for future technological advancements and market strategies. Based on these findings, the study proposes recommendations to further promote the sustainable development of collaborative robot technology, including strengthening technological innovation, optimizing market positioning, fostering emerging enterprises and talent, enhancing international cooperation, and aligning with policy directions.
    Keywords:  Collaborative robots; Geographical distribution; PatSnap; Patent analysis; Technological innovation
    DOI:  https://doi.org/10.1038/s41598-025-14074-0
  51. J Alzheimers Dis Rep. 2025 Jan-Dec;9:9 25424823251368883
    A bibliometric and systematic review of the global impact of air pollution on Alzheimer's disease: Insights from cohort studies.
    Faezeh Jahedi, Gholamreza Goudarzi, Mehdi Ahmadi, Farhad Safdari.
       Background: Emerging evidence highlights the potential role of environmental factors, particularly air pollution, in the development and progression of Alzheimer's disease (AD). Air pollutants may contribute to neurodegenerative processes through mechanisms such as oxidative stress, neuroinflammation, and disruption of the blood-brain barrier.
    Objective: This review aims to systematically evaluate global cohort studies investigating the association between long-term exposure to key air pollutants-specifically particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3)-and the risk of AD.
    Methods: A total of 31 peer-reviewed cohort studies were included based on a structured search strategy. We analyzed epidemiological outcomes, exposure assessment methodologies, and geographic trends. Additionally, a bibliometric analysis was conducted using VOSviewer to identify major contributors and emerging research themes.
    Results: Findings indicate a consistent association between PM2.5 exposure and increased risk of AD, independent of genetic predisposition and lifestyle factors. Proposed biological mechanisms include oxidative stress, microglial activation, blood-brain barrier disruption, and amyloid-β accumulation. Bibliometric mapping revealed regional concentration of research in North America, Europe, and East Asia, with increasing global interest over the past decade.
    Conclusions: There is mounting evidence linking air pollution to Alzheimer's disease. Advances in exposure assessment have improved the accuracy of epidemiological findings. Public health policies targeting air quality control and further studies on molecular and early-life exposures are essential to mitigate the neurotoxic effects of environmental pollutants.
    Keywords:  Alzheimer's disease; air pollution; cohort studies; particulate matter (PM2.5)
    DOI:  https://doi.org/10.1177/25424823251368883
  52. Pediatr Dermatol. 2025 Aug 17.
    Comparing Pediatric Dermatology Research Funded by the US National Institutes of Health (NIH) With the US Skin Disease Burden in Patients Under 20 Years Old.
    Elyse Mackenzie, Nishita Amancharla, Stephanie Casagrande, Waasae Ayyaz, Madeline Tchack, Noah Musolff, Babar Rao.
       BACKGROUND: Disease burden, measured by disability-adjusted life years (DALYs), is a helpful metric to guide research funding priorities. Pediatric dermatologic conditions significantly contribute to DALYs, yet it is unclear whether NIH funding reflects this burden.
    OBJECTIVES: To compare NIH-funded dermatology research with the most burdensome skin diseases in the United States for patients under 20 years old, as measured by DALYs, and to identify mismatches between funding and disease burden.
    METHODS: A cross-sectional analysis was independently performed by two researchers who matched projects from the 2024 to 2025 NIH Research Portfolio Online Reporting Tools with 10 pediatric dermatology skin conditions and their respective DALYs from the Global Burden of Disease (GBD) 2021 study. NIH-funded research projects were categorized by condition and pediatric focus, and funding allocation was compared to DALYs to evaluate alignment.
    RESULTS: The NIH supported 307 grants totaling $388 million across the 10 skin conditions. Atopic dermatitis received the most funding ($62.99 million), with 47.9% of grants pediatric-focused. Viral skin diseases, despite being second in burden, received only $2.35 million and 0 pediatric grants. Most conditions had fewer than 15% pediatric-focused grants.
    CONCLUSIONS: There is a persistent mismatch between NIH funding and the burden of pediatric skin disease, both in overall funding and in the proportion of research focused on pediatric populations. Increased investment in high-burden, underfunded conditions, particularly those lacking pediatric-specific research, is essential.
    DOI:  https://doi.org/10.1111/pde.70007
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