Cureus. 2025 Feb;17(2): e79342
Mal de débarquement syndrome (MdDS) is a rare neurological condition characterized by a persistent sensation of motion, such as rocking, swaying, or bobbing, typically arising after exposure to passive motion, such as during a cruise, flight, or car travel. Unlike motion sickness, MdDS symptoms often begin after the motion ceases and can persist for weeks, months, or even years, significantly impacting the quality of life. Although the exact pathophysiology remains unclear, it is thought to involve maladaptive neural plasticity in the vestibular and sensory integration systems. Diagnosis is primarily clinical, requiring careful exclusion of other vestibular and neurological disorders. Treatment approaches, including vestibular rehabilitation therapy, transcranial magnetic stimulation, and symptom management, show variable success. This article summarizes the current understanding of MdDS, its clinical features, diagnostic criteria, and therapeutic strategies, emphasizing the need for increased awareness and further research into this debilitating condition.
Keywords: cruise ship syndrome; mal de débarquement syndrome; maladaptive neural plasticity; motion-triggered dizziness; post-motion syndrome; sensory integration; vestibular dysfunction; vestibular rehabilitation therapy