bims-migras 2025-07-13 papers

Issue of 2025–07–13
two papers selected by
Cliff Dominy

Front Cardiovasc Med. 2025 ;12 1611557

Extracellular vesicles in atherosclerosis cardiovascular disease: emerging roles and mechanisms.

Haoxuan Deng, Wei Qiu, Yunyan Zhang, Junyi Hua.

The pathogenesis of atherosclerotic cardiovascular disease is complex, involving multiple cell types and biological processes. Extracellular Vesicles (EVs) are small, cell-derived particles increasingly recognized for their role in cardiovascular diseases. EVs are believed to play key roles in this context by promoting inflammation, regulating intercellular communication, and influencing lipid metabolism. As a crucial mediators of cell communication, EVs contribute to both the progression of atherosclerosis (AS) and plaques stability. Although research on the role of EVs in AS and the role of biomarkers or drug carriers in clinical practice has been expanding, several challenges remain for clinical applications, including the lack of specific therapeutic targets for EVs, flaws in the separation and purification processes, and limited clinical trial data on their safety. This review provides a comprehensive overview of the function of EVs in AS and recent advances in their diagnostic and therapeutic potential, aiming to inform future clinical applications.

Keywords: atherosclerosis; cardiovascular disease; extracellular vesicles; inflammatory response; intercellular communication

DOI: https://doi.org/10.3389/fcvm.2025.1611557

Front Immunol. 2025 ;16 1598407

Extracellular vesicles: molecular messengers and new therapeutic targets in acute myocardial infarction.

Hao Wu, Jinyi Xue, Qiuyu Liu, Zhenxun Wan, Lingling Liang, Shihan Sun, Ping Liu, Mingtai Chen, Mengnan Liu.

Extracellular vesicles (EVs) are nanoscale particles secreted by cells, encapsulating a variety of biomolecules, and have emerged as significant players in the pathophysiology of acute myocardial infarction (AMI). These vesicles exhibit both detrimental and therapeutic effects. On one hand, EVs contribute to AMI progression by promoting apoptosis, exacerbating inflammatory responses, and impairing angiogenesis. On the other hand, they facilitate cardiac repair by enhancing neovascularization, mitigating programmed cell death, and inhibiting fibrosis. This review provides a comprehensive overview of EV biogenesis, release mechanisms, and their dual regulatory roles in AMI, emphasizing the complex interplay of EVs in myocardial injury. Additionally, it explores the potential of EVs as diagnostic biomarkers and therapeutic delivery vehicles, highlighting their importance in advancing diagnostic and therapeutic strategies. By elucidating the multifaceted roles of EVs, this review aims to establish a foundation for their clinical translation, improve their applicability in precision medicine, and explore the promising potential in cardiovascular disease treatment.

Keywords: acute myocardial infarction; biomarkers; cardiac repair; extracellular vesicles; immune modulation; therapeutic targets

DOI: https://doi.org/10.3389/fimmu.2025.1598407