Biofactors. 2025 Nov-Dec;51(6):51(6): e70055
Antonia Cugliari,
Cristina Algieri,
Patrycja Anna Glogowski,
Silvia Granata,
Maria Cotugno,
Chiara Bernardini,
Caroline Lopa,
Margherita Litterio,
Donatella Pietrangelo,
Fabiana Trombetti,
Micaela Fabbri,
Speranza Rubattu,
Salvatore Nesci.
The role of mitochondrial dysfunction underlying increased susceptibility to cerebrovascular disease in hypertension, previously detected in stroke-prone spontaneously hypertensive rats (SHR-SP) fed with a high-salt stroke-permissive Japanese-style diet (JD), was studied for the first time at the molecular level. The Complex I (CI) (dis)assembly in the supramolecular organization of respiratory supercomplexes (SCs) has emerged as the main component impairing the kinetic activity and SCs organization of mitochondrial respiration in SHR-SP compared with the SHR-stroke resistant (SR) strain upon the same dietary condition. The leak of substrate channeling and SCs arrangement in CI-dependent NADH oxidation in JD-fed SHR-SP was not detected in SHR-SR upon the same dietary regimen. Our results highlight that SCs association linked to CI dynamic and stability protects from stroke manifestation.
Keywords: diet; hypertension; mitochondria; respiratory complexes; stroke