bims-tumhet 2025-08-24 papers

Issue of 2025–08–24
two papers selected by
Sergio Marchini, Humanitas Research

Gynecol Oncol. 2025 Aug 18. pii: S0090-8258(25)00961-8. [Epub ahead of print]201 83-85

Prevention, early detection & interception: 15th biennial ovarian cancer research symposium.

This article summarizes the key findings presented in the Prevention, Early Detection, & Interception Session at 15th Biennial Ovarian Cancer Research Symposium organized by the Rivkin Center for Ovarian Cancer and American Association for Cancer Research on September 20-21st in Seattle, Washington. The wide range of topics covered in this session included prevention, early detection, and its interception in basic science, clinical science, and population science. More specifically, risk-reducing salpingo-oophorectomy in women at high-risk of ovarian cancer, biology of early progression, mechanisms involved in the transition from precursor lesion to high grade serous ovarian cancer, population-based studies on prevention, and early detection biomarkers of ovarian cancer were discussed.

Keywords: Early detection; Fallopian tube; Interception; Prevention; Risk reducing salpingooophorectomy

DOI: https://doi.org/10.1016/j.ygyno.2025.08.012

Cell Rep Med. 2025 Aug 12. pii: S2666-3791(25)00371-4. [Epub ahead of print] 102298

Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy.

Rui Xing, Jie Mei, Zhijun Zuo, Hao Zou, Xingjuan Yu, Jing Xu, Rongping Guo, Wei Wei, Limin Zheng.

Tertiary lymphoid structures (TLSs) emerge as crucial determinants of anti-tumor immune responses and clinical outcomes. However, their clinical significance and formation mechanisms in hepatocellular carcinoma (HCC) remain unclear. Here, we demonstrate that hepatic arterial infusion chemotherapy (HAIC) with oxaliplatin, leucovorin, and fluorouracil (FOLFOX) significantly enhances TLS formation in HCC tissues, correlating with improved therapeutic efficacy and prolonged progression-free survival in patients with HCC. Mechanistically, HAIC induces lymphotoxin β (LTβ)-expressing central memory T cell (TCM)-like CD4+ T cells, which activate MMP2+ fibroblasts and FOLR2+CCL4+ macrophages via the LTβ-LTβR axis to drive TLS development. Furthermore, the CXCL12-CXCR4 axis acts as a critical mediator in recruiting these cells to HAIC-treated tumors, thereby facilitating TLS formation and enhancing anti-tumor immunity. These findings highlight the pivotal role of TLSs in HAIC-induced anti-tumor immunity and their significance as robust prognostic biomarkers, offering potential therapeutic targets to optimize clinical outcomes for patients with HCC.

Keywords: central memory T cell; fibroblast; hepatic arterial infusion chemotherapy; hepatocellular carcinoma; macrophage; tertiary lymphoid structures; tumor microenvironment

DOI: https://doi.org/10.1016/j.xcrm.2025.102298